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Katsiaryna Holl, Christophe Sauboin, Emanuele Amodio, Paolo Bonanni, Giovanni Gabutti
BACKGROUND: Varicella is a highly infectious disease with a significant public health and economic burden, which can be prevented with childhood routine varicella vaccination. Vaccination strategies differ by country. Some factors are known to play an important role (number of doses, coverage, dosing interval, efficacy and catch-up programmes), however, their relative impact on the reduction of varicella in the population remains unclear. This paper aims to help policy makers prioritise the critical factors to achieve the most successful vaccination programme with the available budget...
October 21, 2016: BMC Public Health
Katrin Feldbauer, Jan Schlegel, Juliane Weissbecker, Frank Sauer, Phillip G Wood, Ernst Bamberg, Ulrich Terpitz
An optochemokine tandem was developed to control the release of calcium from endosomes into the cytosol by light and to analyze the internalization kinetics of G-protein coupled receptors (GPCRs) by electrophysiology. A previously constructed rhodopsin tandem was re-engineered to combine the light-gated Ca2+-permeable cation channel Channelrhodopsin-2(L132C), CatCh, with the chemokine receptor CXCR4 in a functional tandem protein tCXCR4/CatCh. The GPCR was used as a shuttle protein to displace CatCh from the plasma membrane into intracellular areas...
2016: PloS One
Lisa K Fazio, Casey A Kennedy, Robert S Siegler
We examined whether playing a computerized fraction game, based on the integrated theory of numerical development and on the Common Core State Standards' suggestions for teaching fractions, would improve children's fraction magnitude understanding. Fourth and fifth-graders were given brief instruction about unit fractions and played Catch the Monster with Fractions, a game in which they estimated fraction locations on a number line and received feedback on the accuracy of their estimates. The intervention lasted less than 15 minutes...
2016: PloS One
Alessandro Soranzo, Michelle Newberry
This paper discusses how the 'Uncatchable Smile' illusion in Leonardo da Vinci's La Bella Principessa portrait was discovered. Kemp and Cotte(1) described the expression of the Princess as ambiguous and "subtle to an inexpressible degree". A combination of three methods was used (inter-observation, structured interviews, and psychophysical experiments) to identify what may underlie this 'ambiguity'. The inter-observation and the structured interview methods were firstly applied to generate experimental hypotheses that were successively tested by a series of psychophysical experiments...
October 4, 2016: Journal of Visualized Experiments: JoVE
Zengyi Chang, Chin-Chen Wang, Lin Li
No abstract text is available yet for this article.
October 20, 2016: IUBMB Life
J W Zhang, Q Zeng, L Zhao, M Zhang, L Zhang, Q Gu
Objective: To investigate the association between parental environmental risk factors exposure and the risk for childhood acute lymphoblastic leukemia (ALL). Methods: A total of 179 ALL children cases were selected in Tianjin Blood Disease Hospital and 136 healthy children matched by age, gender and living place were selected in 2015 for a case control study. The data were analyzed with univariate and multivariate non conditional logistic regression models. Results: The results of multivariate logistic regression analysis indicated that sex, history of abortion, exposure in a smoking environment during pregnancy, catching a cold, taking antipyretic analgesics, maternal exposure to air purifying agent, father' s occupational exposure to petroleum products and home decoration during pregnancy were associated with the risk of childhood ALL (P<0...
October 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Matthieu Barbier, James R Watson
Predators of all kinds, be they lions hunting in the Serengeti or fishermen searching for their catch, display various collective strategies. A common strategy is to share information about the location of prey. However, depending on the spatial characteristics and mobility of predators and prey, information sharing can either improve or hinder individual success. Here, our goal is to investigate the interacting effects of space and information sharing on predation efficiency, represented by the expected rate at which prey are found and consumed...
October 2016: PLoS Computational Biology
Brad T Morrow, William B Albright, Rogerio I Neves, Michael J Wilkinson, Thomas D Samson
BACKGROUND: Congenital anophthalmia is a rare anomaly that results in micro-orbitism and craniofacial microsomia. Treatment with static conformers is labor-intensive and provides minimal stimulation for orbital growth that requires eventual reconstruction with orbital osteotomies after skeletal maturity. METHODS: A protocol for the treatment of congenital anophthalmia is presented. Patients underwent a preoperative low-dose radiation computed tomography (CT) scan of the facial bones to assess orbital volume...
October 2016: Journal of Craniofacial Surgery
Marco Ruella, Marcela V Maus
Immunotherapy is the revolution in cancer treatment of this last decade. Among multiple approaches able to harness the power of the immune system against cancer, T cell based immunotherapies represent one of the most successful examples. In particular, biotechnological engineering of protein structures, like the T cell receptor or the immunoglobulins, allowed the generation of synthetic peptides like chimeric antigen receptors and bispecific antibodies that are able to redirect non-tumor specific T cells to recognize and kill leukemic cells...
2016: Computational and Structural Biotechnology Journal
Joong Kon Park, Mazhar Ul-Islam, Muhammad Wajid Ullah, Shaukat Khan, Tahseen Kamal, Salman Ul-Islam, Nasrullah Shah
BACKGROUND: Cellulose being the most abundant polymer has been widely utilized in multiple applications. Its impressive nanofibril arrangement has provoked its applications in numerous fields. Recent trends have been shifted to produce composites of nanocellulose for numerous applications among which the most important ones are its use in medical and environmental prospective. This review has basically focused the development of nanocellulose composites and its applications in resolving environmental hazards...
October 18, 2016: Recent Patents on Nanotechnology
Sonya Nicholl, Holly Seale, Vicky Sheppeard, Sue Campbell-Lloyd
INTRODUCTION: In response to a significant increase of measles cases and a high percentage of unvaccinated adolescents in New South Wales, Australia, a measles high school catch-up vaccination programme was implemented between August and December 2014. This study aimed to explore the factors affecting school-based supplementary immunization activities (SIAs) and to inform future SIA and routine school-based vaccination programme implementation and service provision. METHODS: Focus group analysis was conducted among public health unit (PHU) staff responsible for implementing the SIA catch-up programme...
July 2016: Western Pacific Surveillance and Response Journal: WPSAR
Bounthanom Sengkeopraseuth, Khonesavanh Bounma, Chansone Siamong, Siddhartha Datta, Bouaphanh Khamphaphongphane, Phengta Vongphachanh, Dapeng Luo, Michael O'Reilly, Cindy H Chiu
BACKGROUND: In January 2015, the Lao People's Democratic Republic Ministry of Health received a report of 34 cases of fever and rash with one laboratory-confirmed measles case in Houitone village, Pakseng District of Luang Prabang Province. Between 21 and 27 January, we conducted a field investigation to determine the etiology, magnitude and severity of this outbreak. METHODS: We conducted active case findings in Houitone and neighbouring villages and collected information on age, location, date of rash onset, symptoms and measles vaccination status...
January 2016: Western Pacific Surveillance and Response Journal: WPSAR
Ashfaq Khokhar, Muhammad Kamran Lodhi, Yingwei Yao, Rashid Ansari, Gail Keenan, Diana J Wilkie
Despite an unprecedented amount of health-related data being amassed from various technological innovations, our ability to process this data and extract hidden knowledge has yet to catch up with this explosive growth. Although nursing care plans can be an effective tool to support the achievement of desired patient outcomes, their online collection, storage, and processing is lagging far behind. As a result, the impact of nursing care is not well understood from qualitative as well as quantitative perspectives...
October 18, 2016: Western Journal of Nursing Research
Christopher M Holbrook, Roger A Bergstedt, Jessica Barber, Gale A Bravener, Michael L Jones, Charles C Krueger
Physical removal (e.g., harvest via traps or nets) of mature individuals may be a cost-effective or socially acceptable alternative to chemical control strategies for invasive species, but requires knowledge of the spatial distribution of a population over time. We used acoustic telemetry to determine the current and possible future role of traps to control and assess invasive sea lampreys, Petromyzon marinus, in the St. Marys River, the connecting channel between Lake Superior and Lake Huron. Exploitation rates (i...
September 2016: Ecological Applications: a Publication of the Ecological Society of America
Jonathan A Mee, John R Post, Hillary Ward, Kyle L Wilson, Eric Newton, Ariane Cantin
Effective management of socioecological systems requires an understanding of the complex interactions between people and the environment. In recreational fisheries, which are prime examples of socioecological systems, anglers are analogous to mobile predators in natural predator-prey systems, and individual fisheries in lakes across a region are analogous to a spatially structured landscape of prey patches. Hence, effective management of recreational fisheries across large spatial scales requires an understanding of the dynamic interactions among ecological density dependent processes, landscape-level characteristics, and angler behaviors...
September 2016: Ecological Applications: a Publication of the Ecological Society of America
Sverre Kjeldsen
Results of outcome trials form the basis for treatment guidelines in hypertension. Further outcome trials are needed wherever there are gaps in knowledge. Thus, rationale for setting up and performing and outcome trial with investment of large resources is based on a strong hypothesis.Second, an outcome trial must be done with sufficient statistical power. Power is calculated from the risk level of the people to be investigated and the event rate, the expected benefit of the agent to be investigated and the number of treatment years (number of participants involved and years in the study)...
September 2016: Journal of Hypertension
Bikas K Arya, Sangeeta Das Bhattacharya, Catherine G Sutcliffe, Swapan Kumar Niyogi, Subhasish Bhattacharyya, Sunil Hemram, William J Moss, Samiran Panda, Ranjan Saurav Das, Sutapa Mandal, Dennis Robert, Pampa Ray
BACKGROUND: In addition to reducing Haemophilus influenzae type b (Hib) disease in vaccinated individuals, the Hib conjugate vaccine (HibCV) has indirect effects; it reduces Hib disease in unvaccinated individuals by decreasing carriage. Human immunodeficiency virus (HIV)-infected children are at increased risk for Hib disease and live in families where multiple members may have HIV. The aim of this study is to look at the impact of 2 doses of the HibCV on nasopharyngeal carriage of Hib in HIV-infected Indian children (2-15 years) and the indirect impact on carriage in their parents...
November 2016: Pediatric Infectious Disease Journal
Shu-Cheng Liu, Xiao-Min Han, Ming Shi, Zi-Li Pang
This study aimed to provide evidence of persistent uropathogenic Escherichia coli (UPEC) in female patients with recurrent urinary tract infection (UTI) after antibiotic therapy. We collected biopsies of the bladder, and clean-catch urine samples from 32 women who had episodes of recurrent UTI and were given antibiotic therapy. Urine samples and biopsies were analyzed by conventional bacteriological techniques. Phylogenetic group and 16 virulence factors (VFs) of UPEC were determined using polymerase chain reaction (PCR)...
October 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
Chang Min Lee, Da Won Park, Do Hyun Jung, You Jin Jang, Jong-Han Kim, Sungsoo Park, Seong-Heum Park
In Korea, proximal gastrectomy has recently attracted attention as a better choice of function-preserving surgery for proximal early gastric cancer than total gastrectomy. Of the various strategies to overcome reflux symptoms from remnant stomach, double tract reconstruction not only reduces the incidence of anastomosis-related complications, but is also sufficiently reproducible as a laparoscopic procedure. Catching up with the recent rise of single-port laparoscopic surgeries, we performed a pure single-port laparoscopic proximal gastrectomy with DTR...
September 2016: Journal of Gastric Cancer
Paul Comfort, Robert Williams, Timothy J Suchomel, Jason P Lake
The aim of this study was to compare load-absorption force-time characteristics of the clean from the knee (CK), power clean from the knee (PCK) and clean pull from the knee (CPK). Ten collegiate athletes (age 27.5 ± 4.2 years; height 180.4 ± 6.7 cm; mass 84.4 ± 7.8 kg), performed three repetitions each of the CK, PCK and CPK with 90% of their 1RM power clean on a force platform. The CK load-absorption duration (0.95 ± 0.35 s) was significantly longer compared to the CPK (0.44 ± 0.15 s; p < 0.001, d = 2...
September 27, 2016: Journal of Strength and Conditioning Research
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