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https://www.readbyqxmd.com/read/29351419/maternal-nutrient-restriction-in-guinea-pigs-as-an-animal-model-for-studying-growth-restricted-offspring-with-post-natal-catch-up-growth
#1
Catherine L Nevin, Evan Formosa, Yohei Maki, Brad Matushewski, Timothy R H Regnault, Bryan S Richardson
We determined the impact of moderate maternal nutrient restriction (MNR) in guinea pigs with fetal growth restriction (FGR) on offspring body and organ weights, hypothesizing that FGR-MNR animals will show catch-up growth, but with organ-specific differences. Guinea pig sows were fed ad libitum (Control) or 70% of the control diet from 4 week`s pre-conception, switching to 90% at mid-pregnancy (MNR). Control newborns >95g (appropriate for gestational age or AGA, N=37) and MNR newborns <85g (FGR, N=37) were monitored until neonatal (~25 days) or adult (~110 days) necropsy...
January 10, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29350443/cutting-reduces-variation-in-biomass-production-of-forage-crops-and-allows-low-performers-to-catch-up-a-case-study-of-trifolium-pratense-l-red-clover
#2
Denise Herbert, Klemens Ekschmitt, Volker Wissemann, Annette Becker
Regrowth of fodder plants after grazing and mowing drives the profitability of their cultivation and is therefore an important target trait for plant breeding and agricultural engineering. However, for some fodder plants little is known about their regrowth dynamics in response to grazing or mowing. We analyzed the native response of plant architecture, leaf morphology and growth performance to experimental cutting in wild Trifolium pratense L. (red clover) plants. One hundred fifty potted clover plants were established under controlled field conditions, and half of the plants were cut to 5 cm 3 months after sowing...
January 19, 2018: Plant Biology
https://www.readbyqxmd.com/read/29348631/dynamic-all-optical-drug-screening-on-cardiac-voltage-gated-ion-channels
#3
Jonas Streit, Sonja Kleinlogel
Voltage-gated ion channels (VGCs) are prime targets for the pharmaceutical industry, but drug profiling on VGCs is challenging, since drug interactions are confined to specific conformational channel states mediated by changes in transmembrane potential. Here we combined various optogenetic tools to develop dynamic, high-throughput drug profiling assays with defined light-step protocols to interrogate VGC states on a millisecond timescale. We show that such light-induced electrophysiology (LiEp) yields high-quality pharmacological data with exceptional screening windows for drugs acting on the major cardiac VGCs, including hNav1...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343424/igf1-mapk-erk-signaling-pathway-mediated-programming-alterations-of-adrenal-cortex-cell-proliferation-by-prenatal-caffeine-exposure-in-male-offspring-rats
#4
Guanghui Chen, Chao Yuan, Fangfang Duan, Yanyan Liu, Jinzhi Zhang, Zheng He, Hegui Huang, Chunjiang He, Hui Wang
Our previous study proposed a glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming mechanism for prenatal caffeine exposure (PCE)-induced adrenal developmental dysfunction. Here, we focused on PCE-induced cell proliferation changes of the adrenal cortex in male offspring rats before and after birth and clarified the intrauterine programming mechanism. On gestational day (GD) 20, the PCE group had an elevated serum corticosterone level reduced fetal bodyweight, maximum adrenal sectional area, and elevated adrenal corticosterone and aldosterone contents...
January 14, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29343422/effect-of-foetal-and-infant-growth-and-body-composition-on-respiratory-outcomes-in-preterm-born-children
#5
REVIEW
Sarah J Kotecha, John Lowe, Sailesh Kotecha
Body composition and growth outcomes of preterm-born subjects have been studied by many researchers. In general, preterm-born children have lower height and weight especially in infancy. Despite showing potential for catch-up growth, they continue to lag behind their term counterparts in adolescence and adulthood. The various methods of studying body composition and the differing gestations and ages at which it is assessed may go some way to explaining the inconsistent results observed in different studies...
December 20, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29341513/investment-in-epilepsy-monitoring-units-improves-epilepsy-care-experience-in-a-regional-neuroscience-centre
#6
R N McGinty, D J Costello, B McNamara, P Kinirons, B J Sweeney
An evaluation of the clinical yield of inpatient long-term video-EEG (vEEG) in a new epilepsy monitoring unit (EMU) was undertaken, with findings compared to the centre's prior method of bedside vEEG recording in a standard neurology ward, as reported in 2004. A retrospective analysis of neurophysiology reports for all adults who underwent elective vEEG monitoring in the EMU at Cork University Hospital between January 2015 and July 2016 was conducted. Of 115 vEEG studies in the EMU, 100 (87.0%) were deemed diagnostically conclusive, 14 (12...
August 8, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29341366/impact-of-multiple-stressors-on-juvenile-fish-in-estuaries-of-the-northeast-pacific
#7
Jason D Toft, Stuart H Munsch, Jeffery R Cordell, Kiira Siitari, Van C Hare, Brett Holycross, Lisa A DeBruyckere, Correigh M Greene, Brent B Hughes
A key step in identifying global change impacts on species and ecosystems is to quantify effects of multiple stressors. To date, the science of global change has been dominated by regional field studies, experimental manipulation, meta-analyses, conceptual models, reviews, and studies focusing on a single stressor or species over broad spatial and temporal scales. Here, we provide one of the first studies for coastal systems examining multiple stressor effects across broad scales, focused on the nursery function of 20 estuaries spanning 1600 km of coastline, 25 years of monitoring, and seven fish and invertebrate species along the northeast Pacific coast...
January 17, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29341194/generation-of-red-drum-sciaenops-ocellatus-hematology-reference-intervals-with-a-focus-on-identified-outliers
#8
Kendal E Harr, Kristina Deak, Steven A Murawski, Drury R Reavill, Ryan A Takeshita
BACKGROUND: The Deepwater Horizon (DWH) oil spill in 2010 released millions of barrels of crude oil into the northern Gulf of Mexico, exposing numerous species of animals to the toxic components of oil. A comprehensive assessment of morbidity and mortality caused by DWH oil exposure was undertaken by the DWH Natural Resource Damage Trustees to characterize ecosystem damages. OBJECTIVES: This study aimed to characterize normal hematologic RIs in red drum fish with blood cell descriptions, and to demonstrate the importance of identifying and removing outliers when generating RI...
January 17, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29340237/using-underwater-video-to-evaluate-the-performance-of-the-fukui-trap-as-a-mitigation-tool-for-the-invasive-european-green-crab-carcinus-maenas-in-newfoundland-canada
#9
Jonathan A Bergshoeff, Cynthia H McKenzie, Kiley Best, Nicola Zargarpour, Brett Favaro
The European green crab (Carcinus maenas) is a destructive marine invader that was first discovered in Newfoundland waters in 2007 and has since become established in nearshore ecosystems on the south and west coast of the island. Targeted fishing programs aimed at removing green crabs from invaded Newfoundland ecosystems use Fukui traps, but the capture efficiency of these traps has not been previously assessed. We assessed Fukui traps using in situ observation with underwater video cameras as they actively fished for green crabs...
2018: PeerJ
https://www.readbyqxmd.com/read/29338711/blood-parasite-infections-in-a-wild-population-of-ravens-corvus-corax-in-bulgaria
#10
Peter Shurulinkov, Lachezar Spasov, Georgi Stoyanov, Nayden Chakarov
BACKGROUND: Blood parasites have been studied intensely in many families of avian hosts, but corvids, a particularly cosmopolitan family, remain underexplored. Haemosporidian parasites of the common raven (Corvus corax) have not been studied, although it is the largest, most adaptable, and widespread corvid. Genetic sequence data from parasites of ravens can enhance the understanding of speciation patterns and specificity of haemosporidian parasites in corvids, and shed light how these hosts cope with parasite pressure...
January 16, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29337252/phosphatases-catching-up-with-the-level-of-knowledge-finally-druggable
#11
EDITORIAL
Jukka Westermarck
No abstract text is available yet for this article.
January 11, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29334901/monitoring-vaccine-and-non-vaccine-hpv-type-prevalence-in-the-post-vaccination-era-in-women-living-in-the-basilicata-region-italy
#12
Francesca Carozzi, Donella Puliti, Cristina Ocello, Pasquale Silvio Anastasio, Espedito Antonio Moliterni, Emilia Perinetti, Laurence Serradell, Elena Burroni, Massimo Confortini, Paola Mantellini, Marco Zappa, Géraldine Dominiak-Felden
BACKGROUND: A large free-of-charge quadrivalent HPV (qHPV) vaccination program, covering four cohorts annually (women 11, 14, 17 and 24 years), has been implemented in Basilicata since 2007. This study evaluated vaccine and non-vaccine HPV prevalence 5-7 years post-vaccination program implementation in vaccinated and unvaccinated women. METHODS: This population-based, cross-sectional study was conducted in the public screening centers of the Local Health Unit in Matera between 2012 and 2014...
January 15, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29328554/cross-mapping-of-nursing-care-terms-recorded-in-italian-hospitals-into-the-standardized-nnn-terminology
#13
Fabio D'Agostino, Valentina Zeffiro, Ercole Vellone, Davide Ausili, Romina Belsito, Antonella Leto, Rosaria Alvaro
PURPOSE: To evaluate if nursing diagnoses, interventions, and outcomes, as recorded by nurses in Italian hospitals, were semantically equivalent to the NANDA-I, NIC, and NOC (NNN) terminology. METHODS: A cross-mapping study using a multicenter design. Terms indicating nursing diagnoses, interventions, and outcomes were collected using the D-Catch instrument. Cross-mapping of these terms with NNN terminology was performed. FINDINGS: A sample of 137 nursing documentations was included...
January 12, 2018: International Journal of Nursing Knowledge
https://www.readbyqxmd.com/read/29326114/biomechanics-of-swimming-in-developing-larval-fish
#14
REVIEW
Cees J Voesenek, Florian T Muijres, Johan L van Leeuwen
Most larvae of bony fish are able to swim almost immediately after hatching. Their locomotory system supports several vital functions: fish larvae make fast manoeuvres to escape from predators, aim accurately during suction feeding and may migrate towards suitable future habitats. Owing to their small size and low swimming speed, larval fish operate in the intermediate hydrodynamic regime, which connects the viscous and inertial flow regimes. They experience relatively strong viscous effects at low swimming speeds, and relatively strong inertial effects at their highest speeds...
January 11, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29325420/adolescent-and-caregivers-experiences-of-electronic-adherence-assessment-in-paediatric-problematic-severe-asthma
#15
Amy C Stewart, Kenneth N Gannon, Fran Beresford, Louise Fleming
This study explored the experiences of adolescents and their caregivers regarding adherence to inhaled corticosteroids which are assessed through an electronic monitoring device (EMD). These devices are increasingly being used for assessing medication adherence, yet there is little information about patient's experience of these tools. Semi-structured interviews were conducted with eight adolescents with severe asthma, aged 11-15 years, who were electronically monitored as part of their care, along with their caregivers...
January 1, 2018: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29325101/fauna-ecological-characteristics-and-checklist-of-the-mosquitoes-in-mazandaran-province-northern-iran
#16
Seyed Hassan Nikookar, Mahmoud Fazeli-Dinan, Shahyad Azari-Hamidian, Seyed Nouraddin Mousavi Nasab, Mohsen Aarabi, Seyyed Payman Ziapour, Ahmadali Enayati, Janet Hemingway
Mosquitoes are important vectors of human and animal diseases. This study updates current knowledge on fauna, dominance, and distribution of mosquitoes in Mazandaran Province, Northern Iran, to inform disease control effort. Larval collections, using standard dippers or droppers, and adult collections, using total catches, shelter pits, CDC light traps, and human landing catches, were performed monthly in 30 villages across 16 counties, from May to December 2014. Ovitraps, baited with hay infusion as oviposition attractants or stimulants for Aedes (Stegomyia) mosquitoes, were installed in each village and inspected weekly for eggs...
January 6, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29324836/variation-in-angler-distribution-and-catch-rates-of-stocked-rainbow-trout-in-a-small-reservoir
#17
Brian S Harmon, Dustin R Martin, Christopher J Chizinski, Kevin L Pope
We investigated the spatial and temporal relationship of catch rates and angler party location for two days following a publicly announced put-and-take stocking of rainbow trout (Oncorhynchus mykiss). Catch rates declined with time since stocking and distance from stocking. We hypothesized that opportunity for high catch rates would cause anglers to fish near the stocking location and disperse with time, however distance between angler parties and stocking was highly variable at any given time. Spatially explicit differences in catch rates can affect fishing quality...
2018: PloS One
https://www.readbyqxmd.com/read/29322052/composition-of-anopheles-species-collected-from-selected-malarious-areas-of-afghanistan-and-iran
#18
Helen Hoosh-Deghati, Navid Dinparast-Djadid, Vahideh Moin-Vaziri, Hoda Atta, Abbas Ali Raz, Seyyed Javad Seyyed-Tabaei, Naseh Maleki-Ravasan, Hamzeh Alipour, Sedigheh Zakeri, Eznollah Azar-Gashb
Background: Malarious areas in Iran are close to Afghanistan and Pakistan that urge the researchers to extend their knowledge on malaria epidemiology to the neighboring countries as well. Vectorial capacity differs at species or even at population level, the first essential step is accurate identification of vectors. This study aimed to identify Anopheles species composition in selected malarious areas of Afghanistan and Iran, providing further applied data for other research in two countries...
September 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29321670/clinical-and-experimental-evidence-suggest-a-link-between-kif7-and-c5orf42-related-ciliopathies-through-sonic-hedgehog-signaling
#19
Reza Asadollahi, Justin E Strauss, Martin Zenker, Oliver Beuing, Simon Edvardson, Orly Elpeleg, Tim M Strom, Pascal Joset, Dunja Niedrist, Christine Otte, Beatrice Oneda, Paranchai Boonsawat, Silvia Azzarello-Burri, Deborah Bartholdi, Michael Papik, Markus Zweier, Cordula Haas, Arif B Ekici, Alessandra Baumer, Eugen Boltshauser, Katharina Steindl, Michael Nothnagel, Albert Schinzel, Esther T Stoeckli, Anita Rauch
Acrocallosal syndrome (ACLS) is an autosomal recessive neurodevelopmental disorder caused by KIF7 defects and belongs to the heterogeneous group of ciliopathies related to Joubert syndrome (JBTS). While ACLS is characterized by macrocephaly, prominent forehead, depressed nasal bridge, and hypertelorism, facial dysmorphism has not been emphasized in JBTS cohorts with molecular diagnosis. To evaluate the specificity and etiology of ACLS craniofacial features, we performed whole exome or targeted Sanger sequencing in patients with the aforementioned overlapping craniofacial appearance but variable additional ciliopathy features followed by functional studies...
January 10, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29321614/effects-on-metabolic-parameters-in-young-rats-born-with-low-birth-weight-after-exposure-to-a-mixture-of-pesticides
#20
Terje Svingen, Louise Ramhøj, Karen Mandrup, Sofie Christiansen, Marta Axelstad, Anne Marie Vinggaard, Ulla Hass
Pesticide exposure during fetal life can lead to low birth weight and is commonly observed in reproductive toxicology studies. Associations have also been found in low birth weight babies born from pesticide-exposed gardeners. Since low birth weight is also linked to metabolic disorders, it can be speculated that early life exposure to pesticides could increase the risk of becoming obese or developing diabetes later in life. We have analyzed potential long-term effects of gestational and lactational exposure to a low dose mixture of six pesticides that individually can cause low birth weight: Cyromazine, MCPB, Pirimicarb, Quinoclamine, Thiram, and Ziram...
January 10, 2018: Scientific Reports
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