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https://www.readbyqxmd.com/read/29915723/bovine-milk-lactoferrin-selectively-kills-highly-metastatic-prostate-cancer-pc-3-and-osteosarcoma-mg-63-cells-in-vitro
#1
Joana P Guedes, Cátia S Pereira, Lígia R Rodrigues, Manuela Côrte-Real
Prostate cancer and osteosarcoma are the second most common type of cancer affecting men and the fifth most common malignancy among adolescents, respectively. The use of non-toxic natural or natural-derived products has been one of the current strategies for cancer therapy, owing to the reduced risks of induced-chemoresistance development and the absence of secondary effects. In this perspective, lactoferrin (Lf), a natural protein derived from milk, emerges as a promising anticancer agent due to its well-recognized cytotoxicity and anti-metastatic activity...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29914659/microbial-source-tracking-of-cronobacter-spp
#2
Steve Forsythe
Being able to track bacterial pathogens is essential for epidemiological purposes as well as monitoring in-house production facilities. Common bacterial pathogens, such as Salmonella serovars, are already been well defined, and their detection methods are very advanced. However, this will not be the case for emergent bacterial pathogens, as was the case for Cronobacter. The clinical significance of the organism is due to its association with rare sporadic infections in adults, and severe life-threatening outbreaks of necrotizing enterocolitis and meningitis in newborn babies...
2018: Advances in Applied Microbiology
https://www.readbyqxmd.com/read/29913334/abnormal-placentation-current-evidence-and-review-of-the-literature
#3
REVIEW
Ioannis G Papanikolaou, Ekaterini Domali, George Daskalakis, Marianna Theodora, Eirini Telaki, Petros Drakakis, Dimitrios Loutradis
Abnormal placentation often requires the involvement of a multidisciplinary team of medical caregivers. Practicing Obstetrics is a challenging and skillful duty. This is more obvious in cases of abnormal placentation, which represents one of the most dangerous and complex clinical conditions in materno-fetal medicine. Pathological placentation involves position and invasion abnormalities and represents a serious and potentially life-threatening condition for both the pregnant woman and the fetus. The dramatic increase in cesarean section rates is an important factor which could explain the rapid raise in abnormal placentation cases, which were considered rare a few years ago...
June 5, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29910817/treating-heart-inflammation-with-interleukin-1-blockade-in-a-case-of-erdheim-chester-disease
#4
Alessandro Tomelleri, Giulio Cavalli, Giacomo De Luca, Corrado Campochiaro, Teresa D'Aliberti, Moreno Tresoldi, Lorenzo Dagna
Pericarditis is an inflammatory heart disease, which may be idiopathic or secondary to autoimmune or auto-inflammatory diseases and often leads to severe or life-threatening complications. Colchicine and non-steroidal anti-inflammatory drugs represent the mainstay of treatment, whereas use of corticosteroids is associated with recurrence of disease flares. While effective and safe anti-inflammatory therapies remain an unmet clinical need, emerging clinical and experimental evidence points at a promising role of inhibition of the pro-inflammatory cytokine interleukin-1 (IL-1)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29910804/targeting-inflammatory-t-helper-cells-via-retinoic-acid-related-orphan-receptor-gamma-t-is-ineffective-to-prevent-allo-response-driven-colitis
#5
Vera Buchele, Benjamin Abendroth, Maike Büttner-Herold, Tina Vogler, Johanna Rothamer, Sakhila Ghimire, Evelyn Ullrich, Ernst Holler, Markus F Neurath, Kai Hildner
Intestinal graft-versus-host disease (GvHD) is a life-threatening, inflammatory donor T cell-mediated complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). In the light of the reported efficacy of interleukin-23 (IL-23)-blockade to mitigate syngeneic intestinal inflammation in inflammatory bowel disease patients, targeting IL-23 and thereby interleukin-17a (IL-17a) producing T helper (Th17) cells as the T cell subset assumed to be mostly regulated by IL-23, has emerged as a putatively general concept to harness immune-mediated mucosal inflammation irrespective of the underlying trigger...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29910479/hypoglycemia-in-dogs-causes-management-and-diagnosis
#6
REVIEW
Olutunbi Idowu, Kathryn Heading
Hypogylcemia in dogs is defined as a blood glucose concentration of less than 3.3 mmol/L (60 mg/dL) and is a relatively common problem encountered in veterinary practice. This metabolic disorder can have an array of clinical signs, ranging from subtle abnormalities to a life-threatening emergency. Hypoglycemia can be due to several physiological processes or etiologies. It is imperative that the clinician is astute in diagnosing hypoglycemia, proficient in providing rapid symptomatic treatment (if indicated) and has a clear diagnostic plan to elucidate the underlying cause...
June 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/29909939/renal-artery-embolization-in-a-child-with-delayed-hemodynamic-instability-from-penetrating-knife-wound
#7
M Barras, E Pearson, I Cousin, C Le Rouzic, M Thepaut, J-C Gentric, J-M Roue, S Yevich, P de Vries
Penetrating laceration injury in the pediatric population may present as an acute or delayed life-threatening injury. Although emergent intra-arterial embolization is commonly utilized in adults, few cases have been reported for children. Surgical treatment for severe renal laceration injuries may require complete nephrectomy; an unfortunate outcome for a pediatric patient if a renal-preserving alternative is feasible. We present a case of penetrating renal laceration in a 10-year-old boy treated with intra-arterial embolization of the lacerated dominant renal artery and subsequent renal perfusion by an uninjured accessory renal artery allowing for renal preservation...
June 14, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29908723/static-rope-evacuation-by-helicopter-emergency-medical-services-in-rescue-operations-in-southeast-norway
#8
Martin Samdal, Helge H Haugland, Cato Fjeldet, Marius Rehn, Mårten Sandberg
INTRODUCTION: Physician-staffed helicopter emergency medical services (HEMS) in Norway are an adjunct to existing search and rescue services. Our aims were to study the epidemiological, operational, and medical aspects of HEMS daylight static rope operations performed in the southeastern part of the country and to examine several quality dimensions that are characteristic of this service. METHODS: We reviewed the static rope operations performed at 3 HEMS bases during a 3-y period and applied a set of quality indicators designed for physician-staffed emergency medical services to evaluate the quality of care...
June 13, 2018: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/29907267/critical-care-airway-management
#9
REVIEW
Etieno U Umobong, Paul H Mayo
Critical care airway management is associated with a variety of complications, including severe oxygen desaturation, life-threatening hypotension, and death. This article reviews aspects of airway management that are relevant to intensivists and emergency medicine clinicians tasked with improving the quality of urgent endotracheal intubation in the critically ill patient.
July 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29906380/points-pearls-managing-shoulder-injuries-in-the-emergency-department-fracture-dislocation-and-overuse
#10
Richard Pescatore, Andrew Nyce, Nachi Gupta, Jeffrey Nusbaum
The complex structures of the shoulder can be injured by fracture, dislocation, and overuse, and correctly identifying and classifying injury is essential to avoiding pain, disability, and life- and limb-threatening complications. This issue presents a systematic approach to classifying shoulder injuries based on the mechanism of injury and clinical presentation, choosing appropriate imaging, and determining the best strategies for treatment, including reduction, surgical consultation, or outpatient referral...
June 1, 2018: Emergency Medicine Practice
https://www.readbyqxmd.com/read/29901638/multiple-penetrating-aortic-ulcers-and-rupture-of-superior-mesenteric-artery-branch-presenting-with-symptoms-similar-to-unstable-angina-a-case-report
#11
Suqiao Zhang, Rui Lian, Guoqiang Zhang
RATINALE: Penetrating aortic ulcer (PAU) and rupture of a superior mesenteric artery branch is a rare but potentially life-threatening condition. PATIENT CONCERNS: We describe a case of 73-year-old man was brought to our Emergency Department for intermittent back pain. DIAGNOSES: The final diagnoses are PAU (Stanford B) and rupture of a branch of the superior mesenteric artery. INTERVENTIONS: Two covered stents were placed in the thoracic aorta and the right external iliac artery, and the superior mesenteric artery branch was embolized...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901546/improving-disaster-preparedness-of-families-with-a-parenteral-nutrition-dependent-child
#12
Khadija T Toor, Rita V Burke, Natalie E Demeter, Jeffrey S Upperman, Russell J Merritt, Catherine J Goodhue, Choo Phei Wee
OBJECTIVES: Disruption in the care of special healthcare needs children may lead to life-threatening situations or preventable secondary conditions. California averages more than one hundred earthquakes per week. Subsequent power outages, damage to utility systems, and road damage after an earthquake can have grave consequences for families with parenteral nutrition (PN)-dependent children. The purpose of the study was to demonstrate that we could improve disaster preparedness of families with PN-dependent children utilizing individualized family education and distribution of personalized disaster survival toolkits...
June 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29900230/spleen-data-cerium-oxide-nanoparticles-attenuate-polymicrobial-sepsis-induced-spenic-damage-in-male-sprague-dawley-rats
#13
Kevin M Rice, Venkata Vinay Kumar Bandarupalli, Nandini D P K Manne, Eric R Blough
Sepsis is a serious life threatening medical emergency which, if not treated properly, oftentimes results in organ failure and death. Current sepsis treatment protocols are largely centered on the use of antibiotics and supportive care. Recent studies have suggested that antibiotics fail to be effective for sepsis treatment when administered during hypo-dynamic phase of sepsis that is usually characterized by the presence of a cytokine storm. As such, there is an urgent need to develop novel therapeutic drugs that target the inflammatory cytokines that are secreted as a result of increased reactive oxygen species...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29899727/flecainide-induced-brugada-syndrome-in-a-patient-with-skeletal-muscle-sodium-channelopathy-a-case-report-with-critical-therapeutical-implications-and-review-of-the-literature
#14
Michele Cavalli, Barbara Fossati, Raffaele Vitale, Elisa Brigonzi, Vito A G Ricigliano, Lorenzo Saraceno, Rosanna Cardani, Carlo Pappone, Giovanni Meola
Skeletal muscle sodium channelopathies are a group of neuromuscular disorders associated with mutations in the SCN4A gene. Because principal sodium channel isoforms expressed in the skeletal muscles and the heart are distinct one from the other, this condition usually spares cardiac functioning. Nonetheless, evidence on a possible link between skeletal muscle and cardiac sodium channelopathies has emerged in recent years. To date, eight patients bearing pathogenetic mutations in the SCN4A gene and manifesting cardiac electrophysiological alterations have been reported in literature...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29898830/is-there-need-for-technical-investigations-in-order-to-predict-potential-length-of-hospital-stay-of-oral-infections
#15
Maximiliaan Smeets, Bert Gemels, Lisanne Groeneveldt, Constantinus Politis
OBJECTIVE: Oral and maxillofacial infections are generally treated by primary dental or medical caregivers. Nevertheless, because these infections are known to have life-threatening complications, there is a need of clear indicators for emergency services medical staff, particularly in determining when morbidity can be expected and when in-hospital treatment is required. This retrospective study aimed to identify variables that were observable at admission, which could indicate high complication rates, long hospital stays, and/or a need for tracheostomy...
June 10, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29898464/impact-of-different-aortic-entry-tear-sites-on-early-outcomes-and-long-term-survival-in-patients-with-stanford-a-acute-aortic-dissection
#16
Julia Merkle, Anton Sabashnikov, Antje Christin Deppe, Saskia Weber, Navid Mader, Yeong-Hoon Choi, Oliver Liakopoulos, Ferdinand Kuhn-Régnier, Thorsten Wahlers
BACKGROUND:  Stanford A acute aortic dissection (AAD) is a life-threatening emergency. The aim of this study was to compare the impact of three different aortic entry tear sites on early outcomes and long-term survival of patients with Stanford A AAD. METHODS:  From January 2006 to April 2015, a total of 240 consecutive patients with diagnosed Stanford A AAD underwent emergent, isolated surgical aortic repair in our center. Patients were divided into three groups comprising isolated ascending aorta, proximal aortic arch, and distal aortic arch entry tear site and were followed up for up to 9 years...
June 13, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29896465/start-a-neonatal-extracorporeal-membrane-oxygenation-program-a-multistep-team-training
#17
Genny Raffaeli, Stefano Ghirardello, Mara Vanzati, Chiara Baracetti, Francesco Canesi, Federica Conigliaro, Valerio Gentilino, Francesco Macchini, Monica Fumagalli, Fabrizio Ciralli, Nicola Pesenti, Sofia Passera, Simona Neri, Stefania Franzini, Ernesto Leva, Laura Plevani, Fabio Mosca, Giacomo Cavallaro
Background: Extracorporeal membrane oxygenation (ECMO) is a complex life-saving support for acute cardio-respiratory failure, unresponsive to medical treatment. Emergency events on ECMO are rare but require immediate and proficient management. Multidisciplinary ECMO team members need to acquire and maintain over time cognitive, technical and behavioral skills, to safely face life-threatening clinical scenarios. Methods: A multistep educational program was delivered in a 4-year period to 32 ECMO team members, based on guidelines from the Extracorporeal Life Support Organization...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29896172/recent-advances-and-ongoing-challenges-in-the-diagnosis-of-microbial-infections-by-maldi-tof-mass-spectrometry
#18
Walter Florio, Arianna Tavanti, Simona Barnini, Emilia Ghelardi, Antonella Lupetti
Timeliness and accuracy in the diagnosis of microbial infections are associated with decreased mortality and reduced length of hospitalization, especially for severe, life-threatening infections. A rapid diagnosis also allows for early streamlining of empirical antimicrobial therapies, thus contributing to limit the emergence and spread of antimicrobial resistance. The introduction of matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry (MS) for routine identification of microbial pathogens has profoundly influenced microbiological diagnostics, and is progressively replacing biochemical identification methods...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29895450/life-threatening-allergic-reactions-increasing-among-children
#19
Deborah L McBride
Anaphylaxis, a sudden and potentially life-threatening allergic reaction, is increasing among children according to a new report. As the rate rises, there is an increased need for awareness and education for parents and caregivers to help them recognize and treat anaphylaxis. For children who do are at-risk of an anaphylactic reaction, parents and teachers need to be vigilant about the signs of anaphylaxis and to begin treatment quickly. The chances of a positive outcome are increased if necessary medications are on hand during a life-threatening situation...
June 9, 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29893153/toxicity-and-efficacy-of-nanoparticle-mediated-gene-therapy-in-clinical-study
#20
Xiao Liang, Li Liu, Yu-Quan Wei, Guangping Gao, Xiawei Wei
Considerable efforts have been devoted in the development of safe and efficient gene therapy for life-threatening or inherited diseases. The delivery alternatives play key roles in enhancing the therapeutic effect of nucleic cargo. To date, both the viral vectors and non-viral vectors were utilized and evaluated in clinical trials. With the improvement of material science and nanotechnologies, positively charged nanoparticles have emerged as potential gene delivery systems. In this review, we highlighted the clinical trials concerned with cationic nanocarrier mediated gene therapy...
June 12, 2018: Human Gene Therapy
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