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Impingement

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https://www.readbyqxmd.com/read/29772952/femoroacetabular-impingement-the-past-current-controversies-and-future-perspectives
#1
Naoki Nakano, Vikas Khanduja
No abstract text is available yet for this article.
May 17, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29772223/design-of-a-small-scale-multi-inlet-vortex-mixer-for-scalable-nanoparticle-production-and-application-to-the-encapsulation-of-biologics-by-inverse-flash-nanoprecipitation
#2
Chester E Markwalter, Robert K Prud'homme
Flash NanoPrecipitation (FNP) is a scalable approach to generate polymeric nanoparticles using rapid micromixing in specially-designed geometries such as a confined impinging jets (CIJ) mixer or a Multi-Inlet Vortex Mixer (MIVM). A major limitation of formulation screening using the MIVM is that a single run requires tens of milligrams of the therapeutic. To overcome this, we have developed a scaled-down version of the MIVM, requiring as little as 0.2 mg of therapeutic, for formulation screening. The redesigned mixer can then be attached to pumps for scale-up of the identified formulation...
May 14, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29771958/cooperation-of-bmp-and-ihh-signaling-in-interdigital-cell-fate-determination
#3
Arunima Murgai, Sara Altmeyer, Stephanie Wiegand, Przemko Tylzanowski, Sigmar Stricker
The elaborate anatomy of hands and feet is shaped by coordinated formation of digits and regression of the interdigital mesenchyme (IM). A failure of this process causes persistence of interdigital webbing and consequently cutaneous syndactyly. Bone morphogenetic proteins (BMPs) are key inductive factors for interdigital cell death (ICD) in vivo. NOGGIN (NOG) is a major BMP antagonist that can interfere with BMP-induced ICD when applied exogenously, but its in vivo role in this process is unknown. We investigated the physiological role of NOG in ICD and found that Noggin null mice display cutaneous syndactyly and impaired interdigital mesenchyme specification...
2018: PloS One
https://www.readbyqxmd.com/read/29768929/current-concepts-in-revision-hip-arthroscopy
#4
Renato Locks, Ioanna Bolia, Hajime Utsunomiya, Karen Briggs, Marc J Philippon
Hip arthroscopy is an evolving procedure and its indications have expanded. The number of patients undergoing this procedure has increased significantly as well as the number of surgeons being trained. This has resulted in a notable increase in post-operative complication rates creating the need to develop advanced hip arthroscopic techniques. Revision hip arthroscopy is often complex and many factors should be considered to achieve a satisfactory clinical outcome. Careful pre-operative planning and agreement of expectations between the physician and patient regarding the procedure are important...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29768212/mtor-senses-environmental-cues-to-shape-the-fibroblast-like-synoviocyte-response-to-inflammation
#5
Thomas Karonitsch, Richard K Kandasamy, Felix Kartnig, Barbara Herdy, Karolina Dalwigk, Birgit Niederreiter, Johannes Holinka, Florian Sevelda, Reinhard Windhager, Martin Bilban, Thomas Weichhart, Marcus Säemann, Thomas Pap, Günter Steiner, Josef S Smolen, Hans P Kiener, Giulio Superti-Furga
Accumulating evidence suggests that metabolic master regulators, including mTOR, regulate adaptive and innate immune responses. Resident mesenchymal tissue components are increasingly recognized as key effector cells in inflammation. Whether mTOR also controls the inflammatory response in fibroblasts is insufficiently studied. Here, we show that TNF signaling co-opts the mTOR pathway to shift synovial fibroblast (FLS) inflammation toward an IFN response. mTOR pathway activation is associated with decreased NF-κB-mediated gene expression (e...
May 15, 2018: Cell Reports
https://www.readbyqxmd.com/read/29761113/differences-in-hip-joint-biomechanics-and-muscle-activation-in-individuals-with-femoroacetabular-impingement-compared-with-healthy-asymptomatic-individuals-is-level-ground-gait-analysis-enough
#6
Derek J Rutherford, Janice Moreside, Ivan Wong
Background: Femoroacetabular impingement (FAI) is a recognized cause of hip and groin pain and a significant factor in hip joint function during sport. Objective tests for understanding hip function are lacking in this population. Purpose: To determine whether biomechanical and electromyographic features of hip function during level-ground walking differ between a group diagnosed with FAI and those with no symptoms of FAI. Study Design: Controlled laboratory study...
May 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29753178/the-management-of-dorsal-peroneal-nerve-compression-in-the-midfoot
#7
Baljinder Singh Dhinsa, Laila Hussain, Sam Singh
The foot and ankle specialist will frequently encounter patients with dorsal midfoot pain in clinic. In the presence of midfoot pain and/or paraesthesia, nerve entrapment must be considered. The authors report the outcome of a case series of patients who underwent surgical release of the DPN. Between 2011-2017, a single surgeon operated on seven patients with a diagnosis of DPN entrapment. A retrospective review of the patient's clinical notes was performed, including the operative findings. The average age at presentation was 47 years (range, 31-70 years), and the left foot was affected in four cases...
December 28, 2017: Foot
https://www.readbyqxmd.com/read/29749606/interactions-between-short-and-long-noncoding-rnas
#8
REVIEW
Igor Ulitsky
It is now evident that noncoding RNAs play key roles in regulatory networks determining cell fate and behavior, in a myriad of different conditions, and across all species. Among these noncoding RNAs are short RNAs, such as microRNAs, snoRNAs, and piRNAs, and the functions of those are relatively well understood. Other noncoding RNAs are longer, and their modes of action and functions are also increasingly explored and deciphered. Short RNAs and long noncoding RNAs (lncRNAs) interact with each other with reciprocal consequences for their fates and functions...
May 10, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29748878/clinical-and-radiological-outcome-of-gustilo-type-iii-open-distal-tibial-and-tibial-shaft-fractures-after-staged-treatment-with-posterolateral-minimally-invasive-plate-osteosynthesis-mipo-technique
#9
Xiaojian He, Chuanzhen Hu, Kaihua Zhou, Qilin Zhai, Weifeng Wen, Fugen Pan
OBJECTIVES: To evaluate the methods and the outcomes of Gustilo type III open distal tibial and tibial shaft fractures with severe anterior and medial soft-tissue injuries, treated with posterolateral minimally invasive plate osteosynthesis (MIPO) technique. METHODS: From May 2015 to May 2016, 10 patients with Gustilo type III open distal tibial and tibial shaft fractures with severe anterior and medial soft-tissue injuries (Gustilo-Anderson classification IIIA, 6; IIIB, 4) were treated with staged protocol using posterolateral minimally invasive plate osteosynthesis (MIPO) technique...
May 10, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29747942/avulsion-fracture-of-the-lesser-trochanter-in-adolescents
#10
Thomas Ruffing, Tilmann Rückauer, Frederic Bludau, Alexander Hofmann, Markus Muhm, Arnold J Suda
INTRODUCTION: Avulsion fractures of the lesser trochanter in adolescents are rare. They are a result of a sudden and forceful contraction of the iliopsoas muscle. Functional results in the medium term after non-operative treatment are unknown. Therefore we aimed to report these in the present study. MATERIALS AND METHODS: A retrospective two-center study was performed in a case series treated between 2011 and 2017. All adolescents with an acute avulsion fracture of the lesser trochanter were included...
May 4, 2018: Injury
https://www.readbyqxmd.com/read/29747903/metabolic-hallmarks-of-metastasis-formation
#11
REVIEW
Ilaria Elia, Ginevra Doglioni, Sarah-Maria Fendt
Metastasis to distant organs is a predictor of poor prognosis. Therefore, it is of paramount importance to understand the mechanisms that impinge on the different steps of the metastatic cascade. Recent work has revealed that particular metabolic pathways are rewired in cancer cells to support their transition through the metastatic cascade, resulting in the formation of secondary tumors in distant organs. Indeed, metabolic rewiring induces signaling pathways during initial cancer invasion, circulating cancer cells depend on enhanced antioxidant defenses, and cancer cells colonizing a distant organ require increased ATP production...
May 7, 2018: Trends in Cell Biology
https://www.readbyqxmd.com/read/29741957/effects-of-proud-large-osteochondral-plugs-on-contact-forces-and-knee-kinematics-a-robotic-study
#12
Peter Z Du, Keith L Markolf, Daniel V Boguszewski, Kent T Yamaguchi, Christopher J Lama, David R McAllister, Kristofer J Jones
BACKGROUND: Osteochondral allograft (OCA) transplantation is used to treat large focal femoral condylar articular cartilage defects. A proud plug could affect graft survival by altering contact forces (CFs) and knee kinematics. HYPOTHESIS: A proud OCA plug will significantly increase CF and significantly alter knee kinematics throughout controlled knee flexion. STUDY DESIGN: Controlled laboratory study. METHODS: Human cadaver knees had miniature load cells, each with a 20-mm-diameter cylinder of native bone/cartilage attached at its exact anatomic position, installed in both femoral condyles at standardized locations representative of clinical defects...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29739871/canonical-notch-signaling-directs-the-fate-of-differentiating-neurocompetent-progenitors-in-the-mammalian-olfactory-epithelium
#13
Daniel B Herrick, Zhen Guo, Woochan Jang, Nikolai Schnittke, James E Schwob
The adult olfactory epithelium (OE) has the remarkable capacity to regenerate fully both neurosensory and non-neuronal cell types after severe epithelial injury. Life-long persistence of two stem cell populations supports OE regeneration when damaged: the horizontal basal cells (HBCs) -- dormant and held in reserve, and globose basal cells (GBCs) -- a heterogeneous population most of which are actively dividing. Both populations regenerate all cell types of the OE after injury, but the mechanisms underlying neuronal vs...
May 8, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29739788/mapk-reliance-via-acquired-cdk4-6-inhibitor-resistance-in-cancer
#14
Renee de Leeuw, Christopher McNair, Matthew J Schiewer, Neermala P Neupane, Lucas J Brand, Michael A Augello, Zhen Li, Larry C Cheng, Akihiro Yoshida, Sean M Courtney, Starr Hazard, Gerald Hardiman, Maha Hussain, J Alan Diehl, Justin M Drake, William K Kelly, Karen E Knudsen
PURPOSE: Loss of cell cycle control is a hallmark of cancer, which can be targeted with agents, including Cyclin Dependent Kinase-4/6 (CDK4/6) kinase inhibitors that impinge upon the G1-S cell cycle checkpoint via maintaining activity of the retinoblastoma tumor suppressor (RB). This class of drugs is under clinical investigation for various solid tumor types, and has recently been FDA-approved for treatment of breast cancer. However, development of therapeutic resistance is not uncommon...
May 8, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29739596/high-humidity-hot-air-impingement-blanching-hhaib-enhances-drying-rate-and-softens-texture-of-apricot-via-cell-wall-pectin-polysaccharides-degradation-and-ultrastructure-modification
#15
Li-Zhen Deng, A S Mujumdar, Xu-Hai Yang, Jun Wang, Qian Zhang, Zhi-An Zheng, Zhen-Jiang Gao, Hong-Wei Xiao
The effects of high humidity hot air impingement blanching (HHAIB) over a range of application times (30, 60, 90, and 120 s) on drying characteristics, hardness, cell wall pectin fractions contents and nanostructure, as well ultrastructure of apricot were investigated. Results showed that HHAIB reduced drying time and decreased the hardness of apricot by 20.7%-34.5% and 46.57%-71.89%, respectively. The water-soluble pectin (WSP) contents increased after blanching, while the contents of chelate-soluble pectin (CSP) and sodium-carbonate-soluble pectin (NSP) decreased significantly (P < 0...
September 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29739301/sub-elite-football-players-with-hip-related-groin-pain-and-positive-flexion-adduction-internal-rotation-test-exhibit-distinct-biomechanical-differences-compared-with-the-asymptomatic-side
#16
Matthew G King, Adam I Semciw, Harvi F Hart, Anthony G Schache, Kane J Middleton, Josh J Heerey, Rintje Agricola, Kay M Crossley
Study Design Observational cross-sectional study. Background Hip-related groin pain is common in sub-elite football players and may be associated with altered hip biomechanics. Objectives To compare the hip biomechanics, bony hip morphology associated with femoroacetabular impingement (FAI) syndrome, and hip strength and range of motion between the symptomatic and asymptomatic limb of sub-elite football players with unilateral hip-related groin pain and a positive flexion adduction internal rotation test. Methods Fifteen sub-elite football (soccer) players with unilateral hip-related groin pain and a positive flexion adduction internal rotation test were recruited...
May 8, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29736570/surgical-treatment-paradigms-of-ankle-lateral-instability-osteochondral-defects-and-impingement
#17
Hélder Pereira, Gwendolyn Vuurberg, Pietro Spennacchio, Jorge Batista, Pieter D'Hooghe, Kenneth Hunt, Niek Van Dijk
Ankle sprain is amongst the most frequent musculoskeletal injuries, particularly during sports activities. Chronic ankle instability (CAI) resulting from an ankle sprain might have severe long-lasting consequences on the ankle joint. Despite the fact that most patients will respond favourably to appropriate conservative treatment, around 20% will develop symptomatic CAI with sense of giving away and recurrent sprains leading to functional impairment. "Classical" surgical repair by Brostrom-like surgery in one of its many modifications has achieved good results over the years...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29734855/have-large-femoral-heads-reduced-prosthetic-impingement-in-total-hip-arthroplasty
#18
Bradford S Waddell, Chelsea Koch, Myra Trivellas, Jayme C Burket, Timothy Wright, Douglas Padgett
BACKGROUND: Prosthetic impingement is implicated in dislocation after total hip arthroplasty (THA). While use of larger diameter femoral heads reduces the incidence of dislocation, the effect of larger heads upon impingement rate is unknown. We assessed retrieved THA components for evidence of impingement to determine if large femoral heads reduced the rate of impingement in primary THA and what factors might influence impingement. METHODS: Liners from 97 primary THAs retrieved at revision arthroplasty were scored for evidence of impingement, defined as wear or deformation on the rim of the component...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29734501/using-multidimensional-topological-data-analysis-to-identify-traits-of-hip-osteoarthritis
#19
Jasmine Rossi-deVries, Valentina Pedoia, Michael A Samaan, Adam R Ferguson, Richard B Souza, Sharmila Majumdar
BACKGROUND: Osteoarthritis (OA) is a multifaceted disease with many variables affecting diagnosis and progression. Topological data analysis (TDA) is a state-of-the-art big data analytics tool that can combine all variables into multidimensional space. TDA is used to simultaneously analyze imaging and gait analysis techniques. PURPOSE: To identify biochemical and biomechanical biomarkers able to classify different disease progression phenotypes in subjects with and without radiographic signs of hip OA...
May 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29733696/mri-assessment-of-supra-and-infratrochanteric-femoral-torsion-association-with-femoroacetabular-impingement-and-hip-dysplasia
#20
Benjamin Fritz, Susanne Bensler, Michael Leunig, Patrick O Zingg, Christian W A Pfirrmann, Reto Sutter
OBJECTIVE: The objective of our study was to evaluate a novel measurement technique for assessing the supra- and infratrochanteric components of femoral torsion, establish reference values in healthy volunteers, and compare supra- and infratrochanteric torsion angles in patients with hip dysplasia and patients with femoroacetabular impingement (FAI) with those in healthy volunteers. MATERIALS AND METHODS: Femoral torsion was assessed in 380 patients and 61 healthy volunteers on MRI...
May 7, 2018: AJR. American Journal of Roentgenology
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