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https://www.readbyqxmd.com/read/29144507/the-fragile-x-mental-retardation-protein-regulates-tumor-invasiveness-related-pathways-in-melanoma-cells
#1
Francesca Zalfa, Vincenzo Panasiti, Simone Carotti, Maria Zingariello, Giuseppe Perrone, Laura Sancillo, Laura Pacini, Flavie Luciani, Vincenzo Roberti, Silvia D'Amico, Rosa Coppola, Simona Osella Abate, Rosa Alba Rana, Anastasia De Luca, Mark Fiers, Valentina Melocchi, Fabrizio Bianchi, Maria Giulia Farace, Tilmann Achsel, Jean-Christophe Marine, Sergio Morini, Claudia Bagni
The fragile X mental retardation protein (FMRP) is lacking or mutated in patients with the fragile X syndrome (FXS), the most frequent form of inherited intellectual disability. FMRP affects metastasis formation in a mouse model for breast cancer. Here we show that FMRP is overexpressed in human melanoma with high Breslow thickness and high Clark level. Furthermore, meta-analysis of the TCGA melanoma data revealed that high levels of FMRP expression correlate significantly with metastatic tumor tissues, risk of relapsing and disease-free survival...
November 16, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29144021/quantitative-extracellular-matrix-proteomics-suggests-cell-wall-reprogramming-in-host-specific-immunity-during-vascular-wilt-caused-by-fusarium-oxysporum-in-chickpea
#2
Eman Elagamey, Kanika Narula, Arunima Sinha, Sudip Ghosh, Magdi A E Abdellatef, Niranjan Chakraborty, Subhra Chakraborty
Extracellular matrix (ECM) is the unique organelle that perceives stress signals and reprograms molecular events of host cell during patho-stress. However, our understanding of how ECM dictates plant immunity is largely unknown. Vascular wilt caused by the soil borne filamentous fungus Fusarium oxysporum is a major impediment for global crop productivity. To elucidate the role of ECM proteins and molecular mechanism associated with cell wall mediated immunity, the temporal changes of ECM proteome was studied in vascular wilt resistant chickpea cultivar upon F...
November 16, 2017: Proteomics
https://www.readbyqxmd.com/read/29142781/snapping-pes-anserinus-and-the-diagnostic-utility-of-dynamic-ultrasound
#3
Shane A Shapiro, Lorenzo O Hernandez, Daniel P Montero
Snapping pes anserinus syndrome is an often encountered cause of medial knee snapping. It results from impingement and translation of the gracilis tendon or semitendinosus tendon over the osseous structures of the knee during active flexion and extension. Ultrasonography is often the diagnostic imaging test of choice in cases of mechanical snapping. We report 2 cases of painful snapping pes anserinus and highlight the value of dynamic ultrasound in making an accurate diagnosis so as to direct care.
2017: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/29138281/a-conserved-cytoskeletal-signaling-cascade-mediates-neurotoxicity-of-ftdp-17-tau-mutations-in-vivo
#4
Farah H Bardai, Liqun Wang, Yamini Mutreja, Mythili Yenjerla, T Chris Gamblin, Mel B Feany
The microtubule binding protein tau is strongly implicated in multiple neurodegenerative disorders, including frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), which is caused by mutations in tau. In vitro, FTDP-17 mutant versions of tau can reduce microtubule binding and increase aggregation of tau, but the mechanism by which these mutations promote disease in vivo is not clear. Here we take a combined biochemical and in vivo modeling approach to define functional properties of tau driving neurotoxicity in vivo We express wild type human tau and five FTDP-17 mutant forms of tau in Drosophila using a site-directed insertion strategy to ensure equivalent levels of expression...
November 14, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29138040/ultrasound-finding-of-ischiofemoral-impingement-syndrome-and-novel-treatment-with-botulinum-toxin-chemodenervation-a-case-report
#5
Yin-Ting Chen, Keyonna M Jenkins
Ischiofemoral impingement syndrome (IFIS) is a rare and poorly understood condition that leads to deep gluteal pain, groin, and/or medial thigh pain. It has unique diagnostic challenges, with limited non-operative treatment options. It is caused by the impingement of the quadratus femoris by the lesser trochanter and the ischium. Currently there are no validated physical examination maneuvers for IFIS, and the value of ischiofemoral interval for establishing IFIS is also uncertain. Ultrasound-guided corticosteroid injections have been reported...
November 11, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29137727/the-quantitative-evaluation-of-the-relationship-between-the-forces-applied-to-the-palm-and-carpal-tunnel-pressure
#6
Kazutoshi Kubo, Yu-Shiuan Cheng, Boran Zhou, Kai-Nan An, Steven L Moran, Peter C Amadio, Xiaoming Zhang, Chunfeng Zhao
Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy occurring in upper limbs. The etiology, however, has not been fully understood yet. Median nerve could be compressed by either increase of carpal tunnel pressure (CTP) or direct impingement when it is forced toward to carpal ligament especially in wrist flexion leading to CTS development. Thus, the increase of carpal tunnel pressure is considered an important role in CTS development. It has been identified that forces applied to the palm would affect the CTP...
November 4, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29137665/treatment-for-lateral-patellar-impingement-syndrome-with-arthroscopic-lateral-patelloplasty-a-bidirectional-cohort-study
#7
Tianhao Wu, Shiyu Tang, Fei Wang
BACKGROUND: Anterior knee pain is one of the most common musculoskeletal complaints of young patients. We notice that some patients had normal femoral trochlear, medial and lateral patellar retinaculum, and special patellar morphology, which resulted in a series of symptoms in the flexion of the knee due to the impingement of the lateral articular surface of the patella with the femur. We firstly termed this pathologic process as lateral patellar impingement syndrome (LPIS). This ambispective cohort study was to explore the curative effect of arthroscopic lateral patelloplasty for early LPIS...
November 14, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29137087/isolated-tear-of-the-cord-like-middle-glenohumeral-ligament-in-buford-complex-a-case-report
#8
Byung-Ill Lee, Yong Beom Kim, Sung Hun Won, Shu Chiang Hwang, Sung-Woo Choi, Jae-Hwi Nho, Dong-Il Chun
RATIONALE: We describe a rare case of the isolated tear in the cord-like middle glenohumeral ligament (MGHL) in Buford complex. To the best of our knowledge, this is the first report in the English literature about the isolated tear of cord-like MGHL in Buford complex. The present report describes in detail our experience with the diagnosis of isolated tear of the cord-like MGHL in Buford complex and management. PATIENT CONCERNS: A 50-year-old female patient visited our hospital with pain and stiffness in the right shoulder that lasted for 9 months...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135610/meralgia-paresthetica-after-spine-surgery-on-the-jackson-table
#9
Nitin Agarwal, Jaydev B Mistry, Preeya V Khandge, David R Hansberry, Ira M Goldstein
Meralgia paresthetica is a non-life-threatening neurological disorder characterized by numbness, tingling, and burning pain over the anterolateral thigh due to impingement of the lateral femoral cutaneous nerve. This disorder has been seen in patients with diabetes mellitus and obesity, but has also been observed in patients after procedures such as posterior spine surgery, iliac crest bone grafts, lumbar disk surgery, hernia repair, appendectomies, and pelvic osteotomies that ultimately lead to compression or damage to the lateral femoral cutaneous nerve...
November 10, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29135269/return-to-play-after-hip-arthroscopic-surgery-for-femoroacetabular-impingement-in-professional-soccer-players
#10
Renato Locks, Hajime Utsunomiya, Karen K Briggs, Shannen McNamara, Jorge Chahla, Marc J Philippon
BACKGROUND: Arthroscopic hip surgery has been shown to be effective in returning professional athletes back to play at a high level of performance in different sports. Limited information exists regarding professional soccer players and their return to play. PURPOSE: To determine the rate and time to return to sport for professional soccer players after hip arthroscopic surgery for the treatment of femoroacetabular impingement (FAI) and to identify possible risk factors associated with a delay in returning to play...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29134841/the-googled-and-googling-analyst
#11
Nathan Kravis
Kierkegaard's concept of leveling is applied to the dynamics of envy, particularly as they come into play among psychoanalysts doing clinical analytic work. This is illustrated in two clinical vignettes. The technocultural surround of the digital age impinges on analytic identity in ways that can evoke fantasied retreats into sameness and erasure of distinction. The "digital reality principle" is introduced as a way of conceptualizing an aspect of the hatred of thinking and certain envious responses to distinction...
October 2017: Journal of the American Psychoanalytic Association
https://www.readbyqxmd.com/read/29128524/numerical-study-of-the-airflow-structures-in-an-idealized-mouth-throat-under-light-and-heavy-breathing-intensities-using-large-eddy-simulation
#12
Xinguang Cui, Wenwang Wu, Eva Gutheil
An excellent understanding of the airflow structures is critical to enhance the efficiency of drug delivery via the human oral airway. The present paper investigates the characteristics of both steady and unsteady airflow structures in an idealized mouth-throat using large eddy simulation (LES). Representative inhalation flow rates of 15L/min at rest and 60L/min in exercise are considered. The study shows that there are more secondary vortices in the pharynx and the laryngeal jet is much longer and more concave in the steady flow field at 15L/min compared to the higher inspiration rate, which decreases the possibility of drug impinging on the wall...
November 8, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29126367/t2-mapping-of-acetabular-cartilage-in-patients-with-femoroacetabular-impingement-at-3-tesla-comparative-analysis-with-arthroscopic-findings
#13
Tobias Hesper, Christina Neugroda, Christoph Schleich, Gerald Antoch, Harish Hosalkar, Rüdiger Krauspe, Christoph Zilkens, Bernd Bittersohl
Objective To evaluate the diagnostic accuracy of T2*-mapping for detecting acetabular cartilage damage in patients with symptomatic femoroacetabular impingement (FAI). Design A total of 29 patients (17 females, 12 males, mean age 35.6 ± 12.8 years, mean body mass index 25.1 ± 4.1 kg/m(2), 16 right hips) with symptomatic FAI underwent T2* MRI and subsequent hip arthroscopy. T2* values were obtained by region of interest analysis in seven radially reformatted planes around the femoral neck (anterior, anterior-superior, superior-anterior, superior, superior-posterior, posterior-superior, posterior)...
November 1, 2017: Cartilage
https://www.readbyqxmd.com/read/29122045/field-dependent-measurement-of-gaas-composition-by-atom-probe-tomography
#14
Enrico Di Russo, Ivan Blum, Jonathan Houard, Gérald Da Costa, Didier Blavette, Lorenzo Rigutti
The composition of GaAs measured by laser-assisted atom probe tomography may be inaccurate depending on the experimental conditions. In this work, we assess the role of the DC field and the impinging laser energy on such compositional bias. The DC field is found to have a major influence, while the laser energy has a weaker one within the range of parameters explored. The atomic fraction of Ga may vary from 0.55 at low-field conditions to 0.35 at high field. These results have been interpreted in terms of preferential evaporation of Ga at high field...
November 10, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/29121462/design-of-lubricant-infused-surfaces
#15
Daniel John Preston, Youngsup Song, Zhengmao Lu, Dion S Antao, Evelyn N Wang
Lubricant infused surfaces (LIS) are a recently-developed and promising approach to fluid repellency for applications in biology, microfluidics, thermal management, lab-on-a-chip, and beyond. The design of LIS has been explored in past work in terms of surface energies which need to be determined empirically for each interface in a given system. Here, we developed an approach which predicts a priori whether an arbitrary combination of solid and lubricant will repel a given impinging fluid. This model was validated with experiments performed in our work as well as in literature and was subsequently used to develop a new framework for LIS with distinct design guidelines...
November 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29119795/hydrogenation-of-co-to-methanol-on-ni-110-through-subsurface-hydrogen
#16
Adam P Ashwell, Wei Lin, Michelle S Hofman, Yuxin Yang, Mark A Ratner, Bruce E Koel, George C Schatz
We present a combined theoretical and experimental study of CO hydrogenation on a Ni(110) surface, including studies of the role of gas phase atomic hydrogen, surface hydrogen, and subsurface hydrogen reacting with adsorbed CO. Reaction mechanisms leading both to methane and methanol are considered. In the reaction involving surface or subsurface hydrogen, we investigate four possible pathways, using density functional theory to characterize the relative energetics of each intermediate, including the importance of further hydrogenation versus C-O bond breaking, where the latter may lead to methane production...
November 9, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29119081/adnexal-masses-in-pregnancy-an-updated-review
#17
REVIEW
Abdullah M Hakoun, Iyad AbouAl-Shaar, Khaled J Zaza, Hussam Abou-Al-Shaar, Mohammad Nour A Salloum
Adnexal masses in pregnancy are not commonly encountered. The majority of these masses are discovered incidentally during routine follow-up. However, some of these masses become symptomatic due to their size, location, and impingement of adjacent structures. Several diagnostic modalities can be utilized for the detection of adnexal masses with different sensitivity and specificity rates. The differential diagnosis of adnexal masses discovered during pregnancy is broad and includes both benign and malignant lesions...
October 2017: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/29117560/timed-synaptic-inhibition-shapes-nmda-spikes-influencing-local-dendritic-processing-and-global-i-o-properties-of-cortical-neurons
#18
Michael Doron, Giuseppe Chindemi, Eilif Muller, Henry Markram, Idan Segev
The NMDA spike is a long-lasting nonlinear phenomenon initiated locally in the dendritic branches of a variety of cortical neurons. It plays a key role in synaptic plasticity and in single-neuron computations. Combining dynamic system theory and computational approaches, we now explore how the timing of synaptic inhibition affects the NMDA spike and its associated membrane current. When impinging on its early phase, individual inhibitory synapses strongly, but transiently, dampen the NMDA spike; later inhibition prematurely terminates it...
November 7, 2017: Cell Reports
https://www.readbyqxmd.com/read/29116328/correlation-between-femoroacetabular-impingement-and-hamstring-tendon-pathology-on-magnetic-resonance-imaging-and-arthrography
#19
Nakul Talathi, Scott LaValva, Angel Lopez-Garib, John D Kelly, Viviane Khoury
Femoroacetabular impingement (FAI) is an abnormality of the femoral head or acetabulum that leads to an increased incidence of cartilaginous injury in the hip. Femoroacetabular impingement has been associated with several structural abnormalities, including osteitis pubis and hip flexor dysfunction. The authors propose that, additionally, FAI may lead to increased damage of the hamstring tendon due to the additional stress placed on the tendon from the limited range of motion of the hip. The authors conducted a retrospective matched-pair study with the magnetic resonance imaging and magnetic resonance arthrography images of 40 patients' hamstrings with FAI and 45 age-matched controls...
November 1, 2017: Orthopedics
https://www.readbyqxmd.com/read/29114626/postarthroscopy-imaging-in-femoroacetabular-impingement-persistent-pain-may-be-due-to-an-insufficient-correction-of-preoperative-abnormalities
#20
Cosimo Tudisco, Salvatore Bisicchia, Sandro Tormenta, Amedeo Taglieri, Ezio Fanucci
Purpose  The purpose of this study was to evaluate the effect of correction of abnormal radiographic parameters on postoperative pain in a group of patients treated arthroscopically for femoracetabular impingement (FAI). Methods  A retrospective study was performed on 23 patients affected by mixed-type FAI and treated arthroscopically. There were 11 males and 12 females with a mean age of 46.5 (range: 28-67) years. Center-edge (CE) and α angles were measured on preoperative and postoperative radiographic and magnetic resonance imaging (MRI) studies and were correlated with persistent pain at follow-up...
March 2017: Joints
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