Suventha Moodley, Elouise Kroon, Charissa C Naidoo, Georgina R Nyawo, Benjamin G Wu, Selisha Naidoo, Tinaye L Chiyaka, Happy Tshivhula, Shivani Singh, Yonghua Li, Robin M Warren, Eileen G Hoal, Erwin Schurr, Jose Clemente, Leopoldo N Segal, Marlo Möller, Grant Theron
Background: Latent tuberculosis infection (LTBI) is common in people living with HIV (PLHIV) in high TB burden settings. Active TB is associated with specific stool taxa; however, little is known about the stool microbiota and LTBI, including in PLHIV. Method : Within a parent study that recruited adult females with HIV from Cape Town, South Africa into predefined age categories (18-25, 35-60 years), we characterised the stool microbiota of those with [interferon- γ release assay (IGRA)- and tuberculin skin test (TST)-positive] or without (IGRA- and TST-negative) LTBI (n=25 per group)...
April 2, 2024: Research Square