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https://www.readbyqxmd.com/read/28544494/4-substituted-thieno-2-3-d-pyrimidines-as-potent-antibacterial-agents-rational-design-microwave-assisted-synthesis-biological-evaluation-and-molecular-docking-studies
#1
Rupinder K Gill, Harpreet Singh, Tilak Raj, Anuradha Sharma, Gagandeep Singh, Jitender Bariwal
In an attempt to discover a new class of antibacterial agents with improved efficacy and to overcome the drug resistant problems, some novel 4-substituted thieno[2,3-d]pyrimidines have been synthesized via microwave assisted methodology and evaluated for their in vitro antibacterial activity against various pathogenic bacterial strains. Compounds 12b and 13c showed the promising inhibitory potencies against S. aureus, B. subtilis, P. aeruginosa and E. coli with MICs ranging from 2 to 10 μg/ml. Compound 13c was also found to be highly potent against methicillin resistant S...
May 23, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28544183/clinical-outcomes-of-intestinal-transplant-recipients-colonized-with-multi-drug-resistant-organisms-a-retrospective-study
#2
Jacques Simkins, Michele I Morris, Jose F Camargo, Rodrigo Vianna, Thiago Beduschi, Lilian M Abbo
Rates of multi-drug resistant organisms (MDRO) colonization among intestinal transplant (ITx) recipients have not been reported. Colonization rates with vancomycin-resistant Enterococcus (VRE), carbapenem-resistant gram-negative bacteria (CR-GNB) and methicillin-resistant Staphylococcus aureus (MRSA) were obtained retrospectively in adults undergoing ITx (isolated or multi-visceral) from 1/2009-12/2015. We assessed for VRE, CR-GNB and MRSA bacteremia during the first year post-transplant for patients colonized with VRE, CR-GNB and MRSA respectively and for those who were not colonized...
May 19, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28543810/in-vitro-bactericidal-activity-of-blue-light-465-nm-phototherapy-on-meticillin-susceptible-and-meticillin-resistant-staphylococcus-pseudintermedius
#3
Amy H Schnedeker, Lynette K Cole, Gwendolen Lorch, Sandra F Diaz, John Bonagura, Joshua B Daniels
BACKGROUND: Staphylococcus pseudintermedius is the most common cause of bacterial skin infections in dogs. Meticillin-resistant infections have become more common and are challenging to treat. Blue light phototherapy may be an option for treating these infections. HYPOTHESIS/OBJECTIVES: The objective of this study was to measure the in vitro bactericidal activity of 465 nm blue light on meticillin-susceptible Staphylococcus pseudintermedius (MSSP) and meticillin-resistant Staphylococcus pseudintermedius (MRSP)...
May 22, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28542601/the-epidemiology-of-staphylococcus-aureus-carriage-in-patients-attending-inner-city-sexually-transmitted-infections-and-community-clinics-in-calgary-canada
#4
Alejandra Ugarte Torres, Angel Chu, Ron Read, Judy MacDonald, Daniel Gregson, Thomas Louie, Johanna Delongchamp, Linda Ward, Joann McClure, Kunyan Zhang, John Conly
BACKGROUND: Although the nares represent the most common carriage site for traditional hospital-associated strains of Staphylococcus aureus (SA), the predominant site of carriage of SA in the community is less certain. METHODS: We conducted a cross-sectional study in 285 patients attending sexually transmitted diseases and inner-city clinics to evaluate the prevalence, body site colonisation and risk factors associated with carriage of methicillin susceptible SA (MSSA)...
2017: PloS One
https://www.readbyqxmd.com/read/28542523/impact-of-maintenance-immunosuppressive-therapy-on-the-fecal-microbiome-of-renal-transplant-recipients-comparison-between-an-everolimus-and-a-standard-tacrolimus-based-regimen
#5
Gianluigi Zaza, Alessandra Dalla Gassa, Giovanna Felis, Simona Granata, Sandra Torriani, Antonio Lupo
BACKGROUND: The gut microbiome is the full set of microbes living in the gastrointestinal tract and is emerging as an important dynamic/fluid system that, if altered by environmental, dietetic or pharmacological factors, could considerably influence drug response. However, the immunosuppressive drug-induced modifications of this system are still poorly defined. METHODS: We employed an innovative bioinformatics approach to assess differences in the whole-gut microbial metagenomic profile of 20 renal transplant recipients undergoing maintenance treatment with two different immunosuppressive protocols...
2017: PloS One
https://www.readbyqxmd.com/read/28540152/epidemiological-clinical-and-microbiological-characteristics-of-patients-with-post-traumatic-osteomyelitis-of-limb-fractures-in-southwest-china-a-hospital-based-study
#6
Jiachen Peng, Youliang Ren, Wenbin He, Zhengdao Li, Jin Yang, Yi Liu, Zhonghui Zheng, Stephen L Kates, Edward M Schwarz, Chao Xie, Youjia Xu
Objective To determine the epidemiological, clinical and microbiological characteristics, of patients with post-traumatic osteomyelitis of extremity fractures, and provide evidence-based guidelines for early diagnosis and treatment, including empiric antibiotic therapy. Methods Human subject research was performed using institutional review board approved protocols. A retrospective chart review was conducted on 5,368 patients diagnosed with extremity traumatic fractures from January 1, 2012 to December 31, 2015, to identify osteomyelitis patients...
2017: J Bone Jt Infect
https://www.readbyqxmd.com/read/28540151/methicillin-resistant-staphylococcus-aureus-sacroiliac-joint-septic-arthritis-in-an-adult-patient-treated-with-daptomycin
#7
Ramy Rashed, Fizan Younis
Sacroiliac joint septic arthritis is a rare disease entity representing 1-2% of all cases of septic arthritis. Establishment of the diagnosis is often challenging given the non-specific presenting features and the potential cross-over with other pathologies. We report the case of a 50 year old gentleman who suffers with psoriasis and presented with sacroiliac joint septic arthritis complicated by Methicillin Resistant Staphylococcus Aureus (MRSA) bacteraemia and an iliopsoas abscess. This was successfully treated conservatively with a course of the novel antibiotic Daptomycin...
2017: J Bone Jt Infect
https://www.readbyqxmd.com/read/28539745/effect-of-tamarindus-indica-l-and-manihot-esculenta-extracts-on-antibiotic-resistant-bacteria
#8
Zenon Machado Lima, Lenilson Santos da Trindade, Genelane Cruz Santana, Francine Ferreira Padilha, Marcelo da Costa Mendonça, Luiz Pereira da Costa, Jorge A López, Maria Lucila Hernández Macedo
BACKGROUND: The chemical composition of plants used in traditional medicine exhibits biologically active compounds, such as tannins, flavonoids, and alkaloids and becomes a promising approach to treat microbial infections, mainly with drug-resistant bacteria. OBJECTIVE: The aim of the present study was to evaluate the hydroethanolic leaf extracts of Tamarindus indica (tamarind) and Manihot esculenta (cassava) as antimicrobial potential against Pseudomonas aeruginosa clinical isolated and Methicillin-resistant Staphylococcus aureus...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28537316/5-benzylidene-4-oxazolidinones-potently-inhibit-biofilm-formation-in-methicillin-resistant-staphylococcus-aureus
#9
Grant A Edwards, Nataliia V Shymanska, Joshua G Pierce
Investigation into the biological function of 5-benzylidene-4-oxazolidinones revealed dose-dependent inhibition of biofilm formation in Methicillin-resistant S. aureus (MRSA). This structurally unusual class of small molecules inhibit up to 89% of biofilm formation with IC50 values as low as 0.78 μM, and disperse pre-formed biofilms with IC50 values as low as 4.7 μM. Together, these results suggest that 4-oxazolidinones represent new chemotypes to enable the study of bacterial biofilms with small molecule chemical probes...
May 24, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28536702/in-vitro-evaluations-and-in-vivo-toxicity-and-efficacy-studies-of-mfm501-against-mrsa
#10
Saiful Azmi Johari, Mastura Mohtar, Sharifah Aminah Syed Mohamad, Mohd Fazli Mohammat, Rohana Sahdan, Azman Mohamed, Mohamad Jemain Mohamad Ridhwan
Previously we have discovered a synthetically derived pyrrolidone alkaloid, MFM501, exhibiting good inhibitory activity against 53 MRSA and MSSA isolates with low cytotoxicity against three normal cell-lines with IC50 values at >625 µg/ml. Time-kill assay, scanning electron microscopy (SEM) analysis, in vivo oral acute toxicity test, and mice peritonitis model were carried out in this study. In the time-kill study, MFM501 showed a less than 3 log10 decrease in bacterial colony concentration value (CFU/ml) which represented a bacteriostatic action while displaying a time-dependent inhibitory mechanism...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28535606/isolation-purification-and-characterization-of-five-active-diketopiperazine-derivatives-from-endophytic-streptomyces-suk-25-with-antimicrobial-and-cytotoxic-activities
#11
Muhanna M Alshaibani, Juriyati Jalil, Nik M Sidik, Siti Junaidah Ahmad, Nurkhalida Kamal, Ruangelie Edrada-Ebel, Noraziah M Zin
On our search for new sources of bioactive secondary metabolites from Streptomyces sp., the ethyl acetate extracts from the endophytic Streptomyces SUK 25 afforded five active diketopiperazines compounds. The aim of this study was to characterize the bioactive compounds isolated from endophytic Streptomyces SUK 25 and evaluate its bioactivity against multiple drug resistance (MDR) bacteria such as Enterococcus raffinosus, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa and Enterobacter spp...
May 24, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28535235/effect-of-cephalexin-plus-trimethoprim-sulfamethoxazole-vs-cephalexin-alone-on-clinical-cure-of-uncomplicated-cellulitis-a-randomized-clinical-trial
#12
Gregory J Moran, Anusha Krishnadasan, William R Mower, Fredrick M Abrahamian, Frank LoVecchio, Mark T Steele, Richard E Rothman, David J Karras, Rebecca Hoagland, Stephanie Pettibone, David A Talan
Importance: Emergency department visits for skin infections in the United States have increased with the emergence of methicillin-resistant Staphylococcus aureus (MRSA). For cellulitis without purulent drainage, β-hemolytic streptococci are presumed to be the predominant pathogens. It is unknown if antimicrobial regimens possessing in vitro MRSA activity provide improved outcomes compared with treatments lacking MRSA activity. Objective: To determine whether cephalexin plus trimethoprim-sulfamethoxazole yields a higher clinical cure rate of uncomplicated cellulitis than cephalexin alone...
May 23, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28535215/empirical-mrsa-coverage-for-nonpurulent-cellulitis-swinging-the-pendulum-away-from-routine-use
#13
Emily K Shuman, Preeti N Malani
No abstract text is available yet for this article.
May 23, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28534905/antimicrobial-peptide-inspired-nh125-analogues-bacterial-and-fungal-biofilm-eradicating-agents-and-rapid-killers-of-mrsa-persisters
#14
Akash Basak, Yasmeen Abouelhassan, Ran Zuo, Hussain Yousaf, Yousong Ding, Robert W Huigens
During microbial infection, antimicrobial peptides are utilized by the immune response to rapidly eradicate microbial pathogens through the destruction of cellular membranes. Inspired by antimicrobial peptides, quaternary ammonium cationic (QAC) compounds have emerged as agents capable of destroying bacterial membranes leading to rapid bacterial death, including the eradication of persistent, surface-attached bacterial biofilms. NH125, an imidazolium cation with a sixteen membered fatty tail, was recently reported to eradicate persister cells and was our starting point for the development of novel antimicrobial agents...
May 23, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28533831/molecular-characterisation-of-methicillin-resistant-staphylococcus-aureus-mrsa-isolated-at-a-large-referral-hospital-in-zambia
#15
Mulemba Tillika Samutela, Annie Kalonda, James Mwansa, Chileshe Lukwesa-Musyani, John Mwaba, Enoch Mulowa Mumbula, Darlington Mwenya, Edgar Simulundu, Geoffrey Kwenda
INTRODUCTION: Methicillin-resistant Staphylococcus aureus (MRSA) is globally recognized as an important public health problem. Whereas comprehensive molecular typing data of MRSA strains is available, particularly in Europe, North America and Australia, similar information is very limited in sub-Saharan Africa including Zambia. METHODS: In this study, thirty two clinical isolates of Staphylococcus aureus, collected at a large referral hospital in Lusaka, Zambia between June 2009 and December 2012 were analysed by Staphylococcal cassette chromosome mec (SCCmec), Staphylococcus protein A gene typing (spa) and detection of the Panton-Valentine Leukocidin genes (pvl)...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28533166/risk-factors-for-30-day-mortality-in-patients-with-methicillin-resistant-staphylococcus-aureus-bloodstream-infections
#16
Pedro Ayau, Ana C Bardossy, Guillermo Sanchez, Ricardo Ortiz, Daniela Moreno, Pamela Hartman, Khulood Rizvi, Tyler C Prentiss, Mary B Perri, Meredith Mahan, Vanthida Huang, Katherine Reyes, Marcus J Zervos
OBJECTIVES: Methicillin-resistant Staphylococcus aureus (MRSA) blood stream infections (BSI) are a major health care problem accounting for a large percentage of nosocomial infections. The aim of this study was to identify risk factors associated with 30-day mortality in patients with MRSA BSI. METHODS: This was a retrospective study performed in Southeast Michigan. Over a 9- year period, total of 1,168 patients were identified with MRSA BSI. Patient demographics and clinical data were retrieved and evaluated using electronic medical health records...
May 19, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28532398/clinical-outcomes-of-linezolid-and-vancomycin-in-patients-with-nosocomial-pneumonia-caused-by-methicillin-resistant-staphylococcus-aureus-stratified-by-baseline-renal-function-a-retrospective-cohort-analysis
#17
Ping Liu, Blair Capitano, Amy Stein, Ali A El-Solh
BACKGROUND: The primary objective of this study is to assess whether baseline renal function impacts treatment outcomes of linezolid and vancomycin (with a dose-optimized regimen) for methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. METHODS: We conducted a retrospective cohort analysis of data generated from a prospective, randomized, controlled clinical trial (NCT 00084266). The analysis included 405 patients with culture-proven MRSA pneumonia. Baseline renal function was stratified based on creatinine clearance...
May 22, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28532029/surfactin-loaded-polyvinyl-alcohol-pva-nanofibers-alters-adhesion-of-listeria-monocytogenes-to-polystyrene
#18
J J Ahire, D D Robertson, A J van Reenen, L M T Dicks
Surfactin-loaded polyvinyl alcohol (PVA) nanofibers were spun using gravity electrospinning. Scanning electron microscopy (SEM) images showed that nanofibers spun with surfactin are free from bead formation and uniform in diameter. The average nanofiber diameters were decreased (273±39nm, 259±39nm and 217±33nm) with increasing levels of surfactin (0.5, 1.0 and 1.5%, w/v) into PVA (10%, w/v). The 10% (w/v) PVA had average fiber diameter of 303±33nm. Atomic force microscopy (AFM) analysis showed that fibers spun with surfactin are not smooth as PVA fibers...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28529502/effect-of-rocket-eruca-sativa-extract-on-mrsa-growth-and-proteome-metabolic-adjustments-in-plant-based-media
#19
Agapi I Doulgeraki, Georgios Efthimiou, Spiros Paramithiotis, Katherine M Pappas, Milton A Typas, George-John Nychas
The emergence of methicillin-resistant Staphylococcus aureus (MRSA) in food has provoked a great concern about the presence of MRSA in associated foodstuff. Although MRSA is often detected in various retailed meat products, it seems that food handlers are more strongly associated with this type of food contamination. Thus, it can be easily postulated that any food could be contaminated with this pathogen in an industrial environment or in household and cause food poisoning. To this direction, the effect of rocket (Eruca sativa) extract on MRSA growth and proteome was examined in the present study...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28529090/continued-expansion-of-usa300-like-methicillin-resistant-staphylococcus-aureus-mrsa-among-hospitalized-patients-in-the-united-states
#20
Isabella A Tickler, Richard V Goering, Jose R Mediavilla, Barry N Kreiswirth, Fred C Tenover
We characterized spa types, SCCmec types, and antimicrobial resistance patterns of 516 methicillin-resistant Staphylococcus aureus (MRSA) isolates, collected between 2011 and 2014 from nares and blood cultures of United States patients. Among nares isolates, 45 spa types were observed; 29.9% were t002/SCCmec II and 30.9% were t008/SCCmec IV. Among blood isolates, 40 spa types were identified; 24.4% were t002/SCCmec II and 39.9% were type t008/SCCmec IV. Compared to data from our 2009-2010 survey, the percentage of t008/SCCmec IV isolates from nares increased significantly (20...
May 6, 2017: Diagnostic Microbiology and Infectious Disease
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