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https://www.readbyqxmd.com/read/28749335/evaluation-of-a-widely-used-culture-based-method-for-detection-of-livestock-associated-meticillin-resistant-staphylococcus-aureus-mrsa-denmark-and-norway-2014-to-2016
#1
Jesper Larsen, Marianne Sunde, Md Zohorul Islam, Anne Margrete Urdahl, Aina Steihaug Barstad, Anders Rhod Larsen, Carl Andreas Grøntvedt, Øystein Angen
We evaluated a widely used culture-based method for detection of livestock-associated meticillin-resistant Staphylococcus aureus (LA-MRSA) in samples collected from pigs and the environment inside pig stables in Denmark and Norway. Selective enrichment in tryptic soy broth containing cefoxitin and aztreonam led to a high ratio of false-negative results (26%; 57/221). On this basis, we recommend reconsidering the use of selective enrichment for detection of LA-MRSA in animal and environmental samples.
July 13, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28748772/epidemiology-and-hospital-readmission-associated-with-complications-of-staphylococcus-aureus-bacteremia-in-pediatrics-over-a-25-year-period
#2
J LE, Q Dam, T Tran, A Nguyen, F C Adler-Shohet, S Kim, K Schmidt, J M Lieberman, J S Bradley
We sought to comprehensively assess the prevalence and outcomes of complications associated with Staphylococcus aureus bacteremia (SAB) in children. Secondarily, prevalence of methicillin resistance and outcomes of complications from methicillin-resistant S. aureus (MRSA) vs. methicillin-susceptible S. aureus SAB were assessed. This is a single-center cross-sectional study of 376 patients ⩽18 years old with SAB in 1990-2014. Overall, 197 (52%) patients experienced complications, the most common being osteomyelitis (33%), skin and soft tissue infection (31%), and pneumonia (25%)...
July 27, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28748087/antimicrobial-effects-of-lysophosphatidylcholine-on-methicillin-resistant-staphylococcus-aureus
#3
Haruko Miyazaki, Naoko Midorikawa, Saki Fujimoto, Natsumi Miyoshi, Hideto Yoshida, Tetsuya Matsumoto
OBJECTIVES: Methicillin-resistant Staphylococcus aureus (MRSA) is an important health care-associated and community-associated pathogen and causes a large number of infections worldwide. For the purpose of application to topical treatment of MRSA infection, we examined the antimicrobial effects of lysophosphatidylcholine (LPC) on MRSA strains. We also investigated the combination effect of LPC and gentamicin on MRSA growth. METHODS: The LPC minimum inhibitory concentrations (MIC) for Gram-positive (S...
July 2017: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/28748029/prevalence-of-and-risk-factors-for-methicillin-resistant-staphylococcus-aureus-colonization-among-human-immunodeficient-virus-infected-outpatients-in-taiwan-oral-candida-colonization-as-a-comparator
#4
Chi-Jung Wu, Wen-Chien Ko, Mao-Wang Ho, Hsi-Hsun Lin, Yun-Liang Yang, Jiun-Nong Lin, I-Wen Huang, Hui-Ying Wang, Jui-Fen Lai, Yih-Ru Shiau, Li-Yun Hsieh, Hui-Ting Chen, Chih-Chao Lin, Wen-Li Chu, Hsiu-Jung Lo, Tsai-Ling Lauderdale
Human immuodeficency virus (HIV)-infected patients receiving highly active antiretroviral therapy (HAART) and community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) have increased in recent years in Taiwan. This study was undertaken to determine the prevalence of and risk factors for nasal and oral S. aureus and MRSA colonization among contemporary HIV-infected populations. Clinical variables for S. aureus and MRSA colonization among HIV-infected outpatients from three hospitals were analyzed and compared with those for oral Candida colonization...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/28743973/in-vivo-efficacy-of-%C3%AE-lactam-tripropeptin-c-in-a-mouse-septicemia-model-and-the-mechanism-of-reverse-%C3%AE-lactam-resistance-in-methicillin-resistant-staphylococcus-aureus-mediated-by-tripropeptin-c
#5
Hideki Hashizume, Yoshiaki Takahashi, Tohru Masuda, Shun-Ichi Ohba, Tomokazu Ohishi, Manabu Kawada, Masayuki Igarashi
Natural lipopeptide antibiotic tripropeptin C (TPPC) revitalizes and synergistically potentiates the activities of the class of β-lactam antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) but not against methicillin-sensitive S. aureus in vitro; however, the mode of action remains unclear. In the course of the study to reveal its mode of action, we found that TPPC inhibited the β-lactamase production induced by cefotiam. This prompted us to focus on the β-lactam-inducible β-lactam-resistant genes blaZ (β-lactamase) and mecA (foreign penicillin-binding protein), as they are mutually regulated by the blaZ/I/R1 and mecA/I/R1 systems...
July 26, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28742812/broad-range-lytic-bacteriophages-that-kill-staphylococcus-aureus-local-field-strains
#6
Virginia Abatángelo, Natalia Peressutti Bacci, Carina A Boncompain, Ariel A Amadio, Soledad Carrasco, Cristian A Suárez, Héctor R Morbidoni
Staphylococcus aureus is a very successful opportunistic pathogen capable of causing a variety of diseases ranging from mild skin infections to life-threatening sepsis, meningitis and pneumonia. Its ability to display numerous virulence mechanisms matches its skill to display resistance to several antibiotics, including β-lactams, underscoring the fact that new anti-S. aureus drugs are urgently required. In this scenario, the utilization of lytic bacteriophages that kill bacteria in a genus -or even species- specific way, has become an attractive field of study...
2017: PloS One
https://www.readbyqxmd.com/read/28739792/transfersomal-phage-cocktail-an-effective-treatment-against-methicillin-resistant-s-aureus-mrsa-mediated-skin-and-soft-tissue-infections-sstis
#7
Sanjay Chhibber, Ashu Shukla, Sandeep Kaur
Emergence of drug resistance has rekindled the interest in phage therapy as an alternative treatment option. Its potency, safety and proven efficacy is worth noting. However, phage therapy still suffers from issues of poor stability, narrow spectrum and poor pharmacokinetic profile. It therefore becomes essential to look into the use of Drug Delivery Systems (DDS) for efficient delivery of lytic phages in vivo For the first time, the present study has evaluated the use of nano-structured lipid based carriers i...
July 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28739477/predictors-of-increased-cost-and-length-of-stay-in-the-treatment-of-postoperative-spine-surgical-site-infection
#8
Todd J Blumberg, Erik Woelber, Carlo Bellabarba, Richard Bransford, Nicholas Spina
Background Context While many risk factors are known to contribute to development of a post-operative surgical site infection (SSI) following spinal surgery, little is known regarding the costs associated management of this complication, or predictors for which patients that will require increased resources for management of SSI. Purpose The aim of this study is to identify specific risk factors for increased treatment costs and length of stay in the management of a postoperative SSI. Study Design/Setting Retrospective cohort study of all patients undergoing spine surgery at a single institution over three consecutive years...
July 21, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28739308/risk-of-surgical-site-infection-in-elective-hip-and-knee-replacements-after-confirmed-eradication-of-mrsa-in-chronic-carriers
#9
Tarang Tandon, Baha J Tadros, Harold Akehurst, Adhish Avasthi, Richard Hill, Madhu Rao
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is globally endemic and is a leading cause of surgical site infection (SSI). The purpose of this study was to evaluate the incidence of SSI in MRSA carriers undergoing elective hip or knee arthroplasty, who had confirmed eradication and to compare it with incidence of SSI in non-MRSA carriers. METHODS: This is a retrospective analysis of 6613 patients who underwent elective total hip arthroplasty (THA; n = 3347) and total knee arthroplasty (TKA; n = 3266) at our institution...
June 29, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28737160/health-and-environmental-risk-assessment-project-for-bottlenose-dolphins-tursiops-truncatus-from-the-southeastern-usa-ii-environmental-aspects
#10
REVIEW
John S Reif, Adam M Schaefer, Gregory D Bossart, Patricia A Fair
Bottlenose dolphins Tursiops truncatus are the most common apex predators found in coastal and estuarine ecosystems along the southeastern coast of the USA, where these animals are exposed to multiple chemical pollutants and microbial agents. In this review, we summarize the results of investigations of environmental exposures evaluated in 360 free-ranging dolphins between 2003 and 2015. Bottlenose dolphins inhabiting the Indian River Lagoon, Florida (IRL, n = 246), and coastal waters of Charleston, South Carolina (CHS, n = 114), were captured, given comprehensive health examinations, and released as part of a multidisciplinary and multi-institutional study of individual and population health...
July 24, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28737008/design-and-synthesis-of-new-4-alkylidene-beta-lactams-benzyl-and-phenethyl-carbamate-as-key-fragments-to-switch-on-the-antibacterial-activity
#11
Daria Giacomini, Giulia Martelli, Miriam Piccichè, Enrico Calaresu, Clementina Elvezia Anna Cocuzza, Rosario Musumeci
The emergence of multidrug resistant bacterial strains is particularly important in some chronic pathologies such as cystic fibrosis (CF), where persistent colonization and selection of resistant strains being favoured by the frequent and repeated use of antibacterial agents. Staphylococcus aureus is a common pathogen in CF patients with an associated increased multidrug resistance. In a previous research we demonstrated that the presence of a 4-alkylidene side chain directly linked to a beta-lactam appeared to strengthen the potency against S...
July 23, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28736974/topical-sevoflurane-for-chronic-venous-ulcers-infected-by-multi-drug-resistant-organisms
#12
Adrián Imbernón-Moya, Francisco Javier Ortiz-de Frutos, Mónica Sanjuan-Alvarez, Isabel Portero-Sanchez, Raúl Merinero-Palomares, Victoria Alcazar
Several anaesthetic drugs have demonstrated antibacterial properties in vitro. Anaesthetics can primarily affect the cell wall of both susceptible and multi-resistant bacteria. They may also have a synergistic effect with conventional antibiotics through an unknown mechanism. We present three cases of a chronic venous ulcer infected by multi-resistant bacteria refractory to conventional systemic antibiotics, including Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA). Treatment with topical sevoflurane was performed for 1 month without systemic antibiotics...
July 23, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28736966/molecular-characterization-of-nasal-methicillin-resistant-staphylococcus-aureus-isolates-from-workers-of-an-automaker-company-in-southeast-iran
#13
Mohammad Hossein Sobhanipoor, Roya Ahmadrajabi, Afsaneh Karmostaji, Fereshteh Saffari
Colonization of methicillin resistant Staphylococccus aureus (MRSA) can occur more commonly in healthy people who live in close together or are in close physical contact with each other. Having knowledge about the molecular characteristics of these strains provides considerable discernment into the epidemiology of this important microorganism. A total of 806 nasal swabs were collected from healthy workers of an automaker company in the southeast of Iran and were analyzed to detect MRSA isolates. Multilocus sequence typing (MLST), spa typing, and detection of staphylococcal cassette chromosome mec (SCCmec) were performed...
July 24, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28736358/-emergence-of-methicillin-resistant-staphylococcus-aureus-sccmec-type-iv-v-epidemic-clones-in-a-large-teaching-hospital-in-china
#14
Yi-Ming Zhong, Rui Yuan, Jian-Sheng Ding, Fang Yang, Wen-En Liu
OBJECTIVE: To investigate the staphylococcal cassette chromosome mec (SCCmec) genotype and molecular epidemiological characteristics of healthcare-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) in a large teaching hospital in China. METHDOS: From January 2012 to December 2012, a total of 71 nonduplicate HA-MRSA were collected in a teaching hospital in Changsha, China. SCCmec types were determined by multiplex PCR, and Panton-Valentine leukocidin (PVL) gene was detected by PCR...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28736269/iodine-lithium-alpha-dextrin-il%C3%AE-d-against-staphylococcus-aureus-skin-infections-a-comparative-study-of-in-vitro-bactericidal-activity-and-cytotoxicity-between-il%C3%AE-d-and-povidone-iodine
#15
A P Zisi, M K Exindari, E K Siska, G G Koliakos
BACKGROUND: As antimicrobial resistance continuously increases, revisiting old antimicrobial agents, modified to enhance efficacy and safety, becomes important. Iodine has been widely used for more than 150 years as a wound and skin disinfectant; it is an effective broad range bactericide, and to date, it lacks reports of resistance development. The most important iodine-based agent is Povidone-Iodine (PVP-I) which provides excellent antibacterial activity. However, its safety profile has been questioned...
July 20, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28735083/incidence-of-methicillin-resistant-staphylococcus-aureus-mrsa-in-microbial-community-of-cancer-patients-and-evaluation-of-their-resistant-pattern
#16
Mervat Morsy Abbas Ahmed El-Gendy, Ahmed Mohamed Ahmed El-Bondkly, Abeer Ali Keera, Amal Mohamed Ali
Cancer patients are prone to MRSA infection due to a number of factors include prolongedhospitalization, intravascular catheterization, compromised host immunity, malignancy, chemotherapy, radiotherapy surgery, prior antibiotic therapy and prolonged operative time. Among 468 Staphylococcus isolates, 283 were methicillin resistant Staphylococcus aureus isolates (MRSA), which indicated the occurrence and prevalence of MRSA isolates among cancer patients. The highest number of MRSA strains were isolated from male (124 isolates), female (90 isolates) followed by children (69 isolates) which represent 43...
July 19, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28735055/molecular-analysis-of-virulence-genes-and-the-accessory-gene-regulator-agr-types-among-methicillin-resistant-staphylococcus-aureus-mrsa-strains
#17
Sara Cheraghi, Leyla Pourgholi, Maryam Shafaati, Shirinsadat Hashemi Fesharaki, Arash Jalali, Rahim Nosrati, MohammadAli Boroumand
OBJECTIVES: Methicillin resistant S. aureus (MRSA) strains are a main cause of hospital-acquired infections and are considered as a serious public-health concern. MRSA isolates have plenty of virulence factors, which are the basis for its pathogenicity. The controlling and coordination of the expression of these genes perform by the accessory gene regulator (agr). The aim of this study was to determine the rate of some virulence genes encoding the enterotoxin, exfoliative toxin genes (eta), the adhesin genes and identification of agr specificity groups in MRSA isolates...
July 19, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28735054/linezolid-activity-against-clinical-gram-positive-cocci-with-advanced-antimicrobial-drug-resistance-in-iran
#18
Hamidreza Houri, Hossein Kazemian, Hadi Sedigh Ebrahim-Saraie, Asieh Taji, Zahra Tayebi, Hamid Heidari
OBJECTIVES: The aim of the study was to investigate the linezolid activity against clinical Gram-positive cocci with advanced antimicrobial drug resistance. METHODS: A collection of methicillin resistant Staphylococcus aureus (MRSA), vancomycin resistant enterococci (VRE), penicillin non-susceptible Streptococcus pneumoniae (PNSP), and group B streptococci (GBS) were isolated from various clinical samples. Antimicrobial susceptibility tests were done using standard methods Subsequently, we investigated linezolid antibacterial activities, the first approved oxazolidinone against isolates by the standard broth microdilution method...
July 19, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28735053/activity-of-dalbavancin-tested-against-gram-positive-clinical-isolates-causing-skin-and-skin-structure-infections-in-paediatric-patients-from-us-hospitals-2014-2015
#19
Michael A Pfaller, Rodrigo E Mendes, Helio S Sader, Mariana Castanheira, Robert K Flamm
OBJECTIVES: This study provides an in vitro analysis of dalbavancin activity against isolates causing skin and skin structure infections (SSSIs) in children. METHODS: 770 Staphylococcus aureus, 167 β-hemolytic streptococci (BHS), 42 coagulase-negative staphylococci (CoNS), 25 Enterococcus faecalis and 13 viridans group streptococci (VGS) were collected from children (<18 y/o) in the United States (2014-2015). RESULTS: Dalbavancin had MIC50/90 values of 0...
July 19, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28735052/spa-typing-and-identification-of-pvl-genes-of-meticillin-resistant-staphylococcus-aureus-isolated-from-a-libyan-hospital-in-tripoli
#20
Mohamed O Ahmed, Keith E Baptiste, Mohamed A Daw, Asma K Elramalli, Yousef M Abouzeeda, Andreas Petersen
OBJECTIVES: The purpose of the study was to investigate the molecular characteristics of meticillin-resistant Staphylococcus aureus (MRSA) isolated from clinical sources in Tripoli, Libya. METHODS: A total of 95 MRSA strains collected at the Tripoli medical Centre were investigated by spa typing and identification of the Panton-Valentine Leukocidin (pvl) genes. RESULTS: A total of 26 spa types were characterized and distributed among nine clonal complexes; CC5 (n=32), CC80 (n=18), CC8 (n=17) and CC22 (n=12) were the most prevalent clonal complexes...
July 19, 2017: Journal of Global Antimicrobial Resistance
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