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https://www.readbyqxmd.com/read/28110412/prevention-of-cardiac-surgery-associated-aki-by-implementing-the-kdigo-guidelines-in-high-risk-patients-identified-by-biomarkers-the-prevaki-randomized-controlled-trial
#1
Melanie Meersch, Christoph Schmidt, Andreas Hoffmeier, Hugo Van Aken, Carola Wempe, Joachim Gerss, Alexander Zarbock
PURPOSE: Care bundles are recommended in patients at high risk for acute kidney injury (AKI), although they have not been proven to improve outcomes. We sought to establish the efficacy of an implementation of the Kidney Disease Improving Global Outcomes (KDIGO) guidelines to prevent cardiac surgery-associated AKI in high risk patients defined by renal biomarkers. METHODS: In this single-center trial, we examined the effect of a "KDIGO bundle" consisting of optimization of volume status and hemodynamics, avoidance of nephrotoxic drugs, and preventing hyperglycemia in high risk patients defined as urinary [TIMP-2]·[IGFBP7] > 0...
January 21, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28110322/classification-of-facial-wrinkles-among-chinese-women
#2
Zhang Jiechen, Hou Wei, Feng Suying, Chen Xiangsheng, Wang Hongwei
It is generally recognized that Caucasians and Asians have different skin aging features. The aim of this study was to develop a facial wrinkle grading scale for Chinese women. Standard photographs were taken of 242 Chinese women. Six sets of 0 to 9 wrinkle scales with reference photographs and descriptions were selected, including grading scales for resting and hyperkinetic crow's feet, frontalis lines, glabellar frown lines, and nasolabial folds. To identify the scale by objective quantitative measurement, skin surface measurements from the Visioscan(®) VC98 were used...
October 17, 2016: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28110297/the-technical-report-on-sodium-intake-and-cardiovascular-disease-in-low-and-middle-income-countries-by-the-joint-working-group-of-the-world-heart-federation-the-european-society-of-hypertension-and-the-european-public-health-association
#3
REVIEW
Giuseppe Mancia, Suzanne Oparil, Paul K Whelton, Martin McKee, Anna Dominiczak, Friedrich C Luft, Khalid AlHabib, Fernando Lanas, Albertino Damasceno, Dorairaj Prabhakaran, Giuseppe La Torre, Michael Weber, Martin O'Donnell, Sidney C Smith, Jagat Narula
Ingestion of sodium is essential to health, but excess sodium intake is a risk factor for hypertension and cardiovascular disease. Defining an optimal range of sodium intake in populations has been challenging and controversial. Clinical trials evaluating the effect of sodium reduction on blood pressure have shown blood pressure lowering effects down to sodium intake of less than 1.5 g/day. Findings from these blood pressure trials form the basis for current guideline recommendations to reduce sodium intake to less than 2...
January 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28110270/assessment-of-neonatal-pain-during-heel-prick-lancet-vs-needle-a-randomized-controlled-study
#4
Carl Britto, Suman P N Rao
BACKGROUND: Heel prick is a frequent painful procedure in newborns. A lancet or a 26-gauge needle is used for a heel prick in India. OBJECTIVE: To compare the pain caused by heel prick with a lancet or a 26-gauge needle in newborns admitted in the neonatal intensive care unit (NICU) using the preterm infant pain profile (PIPP). METHODS: This randomized controlled trial was conducted over 2 months in a Level III NICU with a sample size of 40 subjects (20 in each group), which was required for the study to have a power of 80% with an alpha error of 0...
January 21, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28110207/the-effect-of-physical-activity-on-depressive-symptoms-and-quality-of-life-among-elderly-nursing-home-residents-randomized-controlled-trial
#5
Neslihan Lok, Sefa Lok, Muammer Canbaz
OBJECTIVES: Physical activity may have positive effects on decreasing anxiety, stress and depression, maintaining mental health and ensuring psychological vitality.This study aimed to determine how a "Physical Activity Program" for elderly people in nursing homes affected their depressive symptoms and quality of life. METHODS: We included 80 individuals aged >65years (40 in the intervention group, 40 controls) in this experimental, randomized, controlled pretest-posttest study...
January 16, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28110205/a-systematic-review-of-randomized-controlled-trials-of-interventions-designed-to-decrease-child-abuse-in-high-risk-families
#6
Elizabeth J Levey, Bizu Gelaye, Paul Bain, Marta B Rondon, Christina P C Borba, David C Henderson, Michelle A Williams
Child abuse is a global problem, and parents with histories of childhood abuse are at increased risk of abusing their offspring. The objective of this systematic review is to provide a clear overview of the existing literature of randomized controlled trials evaluating the effectiveness of interventions to prevent child abuse. PubMed, PsychINFO, Web of Science, Sociological Abstracts, and CINAHL were systematically searched and expanded by hand search. This review includes all randomized controlled trials (RCTs) of interventions designed to prevent abuse among mothers identified as high-risk...
January 19, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28110155/first-in-man-study-with-a-novel-pegylated-recombinant-human-insulin-like-growth-factor-i
#7
H Kletzl, A Guenther, A Höflich, C Höflich, J Frystyk, R F Staack, E Schick, C Wandel, N Bleich, F Metzger
OBJECTIVE: This study is a first time assessment of safety and tolerability, pharmacokinetics, and pharmacodynamics of RO5046013 in human, in comparison with unmodified rhIGF-I. DESIGN: The study was conducted as a single-center, randomized, double-blinded, placebo-controlled, single ascending dose, parallel group study in a clinical research unit in France. A total of 62 healthy volunteers participated in this clinical trial. RO5046013 was given as single subcutaneous injection, or as intravenous infusion over 48h, at ascending dose levels...
January 10, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28110112/verbal-memory-functioning-moderates-psychotherapy-treatment-response-for-ptsd-related-nightmares
#8
J Cobb Scott, Gerlinde Harb, Janeese A Brownlow, Jennifer Greene, Ruben C Gur, Richard J Ross
Posttraumatic stress disorder (PTSD) is associated with cognitive deficits in attention, executive control, and memory, although few studies have investigated the relevance of cognitive difficulties for treatment outcomes. We examined whether cognitive functioning and history of traumatic brain injury (TBI) were associated with response to cognitive-behavioral therapy (CBT) for PTSD-related sleep problems. In a randomized controlled trial of Imagery Rehearsal (IR) added to components of CBT for Insomnia (IR + cCBT-I) compared to cCBT-I alone for PTSD-related recurrent nightmares, 94 U...
January 13, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28110111/applying-a-novel-statistical-method-to-advance-the-personalized-treatment-of-anxiety-disorders-a-composite-moderator-of-comparative-drop-out-from-cbt-and-act
#9
Andrea N Niles, Kate B Wolitzky-Taylor, Joanna J Arch, Michelle G Craske
BACKGROUND: No prior studies have examined moderators of dropout between distinct treatments for anxiety disorders. This study applied a novel statistical approach for examining moderators of dropout from traditional cognitive behavioral therapy (CBT) and acceptance and commitment therapy (ACT). METHOD: We combined data from two randomized controlled trials (N = 208) comparing CBT and ACT for patients with DSM-IV anxiety disorders. Adapting Kraemer's method for constructing and evaluating composite moderators (2013), 26 variables were examined for individual effect sizes...
January 4, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28110031/interspinous-process-devices-ipd-alone-versus-decompression-surgery-for-lumbar-spinal-stenosis-lss-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#10
REVIEW
Xing-Wen Zhao, Jian-Xiong Ma, Xin-Long Ma, Fei Li, Wei-Wei He, Xuan Jiang, Yin Wang, Biao Han, Bin Lu
BACKGROUND: and purpose: Interspinous process devices (IPD) were widely used for the treatment of lumbar spinal stenosis (LSS). However, whether IPD was superior to bony decompression was still debated. We aimed to compare the clinical outcomes of IPD to bony decompression for LSS. METHODS: PubMed, Cochrane library, Cochrane Central Register of Controlled Trials (CCTR), Ovid Medline, China national knowledge internet database, Wan Fang database were searched in August...
January 18, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28109939/peripheral-venous-catheter-insertion-simulation-training-a-randomized-controlled-trial-comparing-performance-after-instructor-led-teaching-versus-peer-assisted-learning
#11
Sophie Pelloux, Arnaud Grégoire, Patrice Kirmizigul, Sandrine Maillot, Bernard Bui-Xuan, Guy Llorca, Sylvain Boet, Jean-Jacques Lehot, Thomas Rimmelé
INTRODUCTION: Peripheral venous catheter insertion is a procedural skill that every medical student should master. Training is often limited to a small number of students and is poorly evaluated. The objective of this study was to evaluate the performance of peer-assisted learning in comparison to instructor-led teaching for peripheral venous catheter insertion training. METHODS: Students were randomized to the control group attending a traditional instructor-led training session (slideshow and demonstration by an anaesthetist instructor, followed by training on a procedural simulator) or to the test group attending a peer-assisted training session (slideshow and demonstration video-recorded by the same instructor, followed by training on a procedural simulator...
January 18, 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/28109872/5-year-safety-and-efficacy-of-resolute%C3%A2-zotarolimus-eluting-stent-the-resolute-global-clinical-trial-program
#12
Robert W Yeh, Sigmund Silber, Lianglong Chen, Shaoliang Chen, Shirish Hiremath, Franz-Josef Neumann, Shubin Qiao, Shigeru Saito, Bo Xu, Yuejin Yang, Laura Mauri
OBJECTIVES: The authors evaluated the 5-year cumulative incidence of cardiovascular events following Resolute zotarolimus-eluting stent (R-ZES) implantation. BACKGROUND: Individual trials are often underpowered to show differences for low-frequency adverse events. The R-ZES was studied in 10 prospective clinical trials, designed with identical adverse event definitions, ascertainment, and adjudication. METHODS: The RESOLUTE Global Clinical Trial Program includes 7,618 patients treated with R-ZES: RESOLUTE first-in-human study (N = 139), RESOLUTE All Comers (N = 1,140), RESOLUTE International (N = 2,349), RESOLUTE US (N = 1,402), RESOLUTE US 38 mm (N = 114), RESOLUTE Japan (N = 100), RESOLUTE Japan Small Vessel Study (N = 65), RESOLUTE Asia (N = 311), RESOLUTE China Randomized Controlled Trial (N = 198), and RESOLUTE China Registry (N = 1,800)...
January 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28109628/preoperative-bathing-of-the-surgical-site-with-chlorhexidine-for-infection-prevention-systematic-review-with-meta-analysis
#13
Lúcia Maciel de Castro Franco, Gláucia Fernandes Cota, Tatiana Saraiva Pinto, Flávia Falci Ercole
BACKGROUND: Preoperative bathing with 4% chlorhexidine is recommended as a measure to prevent surgical site infection (SSI) despite uncertainty regarding the effectiveness of the intervention. This review aimed to assess the effect of bathing with 4% chlorhexidine on the prevention of SSIs in clean surgeries compared with bathing with placebo solution or soap. METHODS: Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for systematic reviews and the Cochrane manual were followed...
January 18, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28109620/effect-of-pre-operative-octenidine-nasal-ointment-and%C3%A2-showering-on-surgical-site-infections-in-patients-undergoing-cardiac-surgery
#14
M Reiser, A Scherag, C Forstner, F M Brunkhorst, S Harbarth, T Doenst, M W Pletz, S Hagel
OBJECTIVE: To evaluate the effect of pre-operative octenidine (OCT) decolonization on surgical site infection (SSI) rates. DESIGN: Before-and-after cohort study. PATIENTS: Patients undergoing an elective isolated coronary artery bypass graft (CABG) procedure: control group (1(st) January to 31(st) December 2013), N=475; intervention group (1(st) January to 31(st) December 2014), N=428. INTERVENTIONS: The intervention consisted of nasal application of OCT ointment three times daily, beginning on the day before surgery, and showering the night before and on the day of surgery with OCT soap...
November 18, 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28109576/beta-blockers-reduced-the-risk-of-cardiac-rupture-in-patients-with-acute-myocardial-infarction-a-meta-analysis-of-randomized-control-trials
#15
Wei Gong, Siting Feng, Xiao Wang, Jingyao Fan, Aobo Li, Shao-Ping Nie
BACKGROUND: Cardiac rupture (CR) is a catastrophic complication that occurs after acute myocardial infarction (MI) and, at present, there are no effective pharmacological strategies for preventing this condition. The objective of this meta-analysis was to assess the effect of beta-blockers on CR in patients with acute MI. METHODS: An extensive search of the PUBMED, EMBASE, ISI Web of Science, MEDLINE and Cochrane was performed to retrieve the studies of beta-blockers treatment in patients with acute MI...
January 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28109570/osteopathic-manipulative-treatment-improves-heart-surgery-outcomes-a-randomized-controlled-trial
#16
Vittorio Racca, Bruno Bordoni, Paolo Castiglioni, Maddalena Modica, Maurizio Ferratini
BACKGROUND: Controlling sternal pain after heart surgery is important to reduce the risk of postoperative complications, but pain is often undertreated because of contraindications and side effects of analgesic drugs. Recently, osteopathic manipulative treatment (OMT) was demonstrated to reduce pain in different clinical contexts, suggesting its potential utility after cardiac surgery. The aim of this open-label, controlled study is to assess whether OMT contributes to sternal pain relief and improves postoperative outcomes...
January 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28109565/the-effect-of-n-acetylcysteine-on-exacerbations-of-chronic-obstructive-pulmonary-disease-a-meta-analysis-and-systematic-review
#17
REVIEW
Kaushal Fowdar, Huan Chen, Zhiyi He, Jiujin Zhang, Xiaoning Zhong, Jianquan Zhang, Meihua Li, Jing Bai
N-acetylcysteine (NAC) is an antioxidant and anti-inflammatory. Its effects on chronic obstructive pulmonary (COPD) outcomes, including exacerbation of and changes in lung function parameters, are controversial. To investigate the effects of NAC on COPD exacerbation and changes in lung function parameters in patients with COPD. A meta-analysis of randomized controlled trials retrieved from PubMed and Medline databases (12 trials; 2691 patients). High-dose [relative ratio (RR) = 0.90, 95% confidence interval (CI) = 0...
January 18, 2017: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/28109559/meta-analysis-of-usefulness-of-concomitant-mitral-valve-repair-or-replacement-for-moderate-ischemic-mitral-regurgitation-with-coronary-artery-bypass-grafting
#18
Salah E Altarabsheh, Salil V Deo, Shannon M Dunlay, Patricia J Erwin, Yagthan M Obeidat, Suparna Navale, Alan H Markowitz, Soon J Park
Moderate ischemic mitral regurgitation (MR) is often present in patients undergoing coronary artery bypass grafting (CABG). However, the clinical benefit of repairing moderate MR during CABG is unproven. We searched multiple databases to identify original studies comparing isolated CABG versus combined CABG and MR surgery (mitral valve surgery with coronary artery bypass grafting [MVCABG]); survival (either early or midterm) was the primary end point. Risk ratio (RR) or standardize mean difference was selected as the effect estimates; survival was compared by pooling hazard ratios...
December 9, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28109467/dexamethasone-in-head-and-neck-cancer-patients-with-microvascular-reconstruction-no-benefit-more-complications
#19
S Kainulainen, J Törnwall, A M Koivusalo, A L Suominen, P Lassus
OBJECTIVES: Glucocorticoids are widely used in association with major surgery of the head and neck to improve postoperative rehabilitation, shorten intensive care unit and hospital stay, and reduce neck swelling. This study aimed to clarify whether peri- and postoperative use of dexamethasone in reconstructive head and neck cancer surgery is associated with any advantages or disadvantages. MATERIALS AND METHODS: This prospective double-blind randomized controlled trial comprised 93 patients...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28109324/reporting-of-critical-care-trial-abstracts-a-comparison-before-and-after-the-announcement-of-consort-guideline-for-abstracts
#20
Akira Kuriyama, Naomi Takahashi, Takeo Nakayama
BACKGROUND: An extension of the Consolidated Standards of Reporting Trials (CONSORT) statement provides a checklist of items to improve the reporting quality of abstracts of randomized controlled trials (RCTs). However, authors of abstracts in some fields have poorly adhered to this guideline. We did an extensive literature survey to examine the quality of reporting trial abstracts in major critical care journals before and after announcement of the CONSORT guideline for abstracts. METHODS: We reviewed abstracts of RCTs published in four major critical care journals with publication dates ranging from 2006 to 2007 (pre-CONSORT) and from 2011 to 2012 (post-CONSORT): Intensive Care Medicine (ICM), Critical Care (CC), American Journal of Respiratory and Critical Care Medicine (AJRCCM), and Critical Care Medicine (CCM)...
January 21, 2017: Trials
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