keyword
https://read.qxmd.com/read/38547421/comprehensive-immunogenomic-profiling-of-idh1-2-altered-cholangiocarcinoma
#1
JOURNAL ARTICLE
Shalini Makawita, Sunyoung Lee, Elisabeth Kong, Lawrence N Kwong, Zeyad Abouelfetouh, Anaemy Danner De Armas, Lianchun Xiao, Karthikeyan Murugesan, Natalie Danziger, Dean Pavlick, Anil Korkut, Jeffrey S Ross, Milind Javle
PURPOSE: Isocitrate dehydrogenase ( IDH ) 1 / 2 genomic alterations (GA) occur in 20% of intrahepatic cholangiocarcinoma (iCCA); however, the immunogenomic landscape of IDH1-/2- mutated iCCA is largely unknown. METHODS: Comprehensive genomic profiling (CGP) was performed on 3,067 cases of advanced iCCA. Tumor mutational burden (TMB), PD-L1 expression (Dako 22C3), microsatellite instability (MSI), and genomic loss of heterozygosity (gLOH) as a surrogate marker for homologous recombination deficiency were examined...
March 2024: JCO Precision Oncology
https://read.qxmd.com/read/38546691/myc-overexpression-in-natural-killer-cell-lymphoma-prognostic-and-therapeutic-implications
#2
JOURNAL ARTICLE
Chengfeng Bi, Yuhua Huang, Roshia Ali, Fang Wang, Xia Yang, Alyssa Bouska, Lu Xu, Xinbao Hao, Matthew A Lunning, Wing C Chan, Javeed Iqbal, Dennis D Weisenburger, Julie M Vose, Kai Fu
The current clinical management of Extranodal NK/T-cell lymphoma (ENKTL) primarily depends on conventional chemotherapy and radiotherapy, underscoring the need for innovative therapeutic strategies. This study explores the clinical significance and therapeutic implication of c-MYC (MYC) in ENKTL. Initially, we identified MYC protein overexpression in approximately 75% of cases within a large cohort of 111 patients. MYC overexpression was strongly correlated with lymphoma cell proliferation and poor clinical outcomes...
March 28, 2024: Haematologica
https://read.qxmd.com/read/38546349/immunotoxicity-of-ionic-liquid-c-14-mim-bf-4-in-rats
#3
JOURNAL ARTICLE
Manyu Shu, Pengzhen Tan, Yueyue Ge, Xingxing Tian, Hongmei Xu
Ionic liquid tetrafluoroborated-1-tetradecyl-3-methylimidazole salt ([C14 mim]BF4 ) immunotoxicity was investigated in rats using three exposure groups (12.5, 25, and 50 mg kg-1 ), one recovery group (50 mg kg-1 ), and a control group without any treatment. The findings demonstrated that, at low doses, [C14 mim]BF4 could raise WBC, NEU, and MID and lysozyme levels as well as spleen T-lymphocyte stimulation index in rats, however at high doses, the aforementioned indices were dramatically lowered...
March 28, 2024: Environmental Toxicology
https://read.qxmd.com/read/38545800/immune-microenvironment-of-human-papillomavirus-positive-head-and-neck-squamous-cell-carcinoma
#4
REVIEW
Dong Zhu, Xiang He, Yu Li, Guoping Li, Min Chen
OBJECTIVES: Research progress of human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) based on immune microenvironment. METHODS: This article preliminarily discusses the composition of immune microenvironment components and immune therapy and elaborates and analyzes the involvement and impact of T cells, B cells, natural killer (NK) cells, tumor-associated fibroblasts, and bone marrow-derived suppressor cells in HPV-positive HNSCC on tumor progression and prognosis...
2024: Science Progress
https://read.qxmd.com/read/38545758/tigit-blockade-reshapes-the-tumor-microenvironment-based-on-the-single-cell-rna-sequencing-analysis
#5
JOURNAL ARTICLE
Yanyan Lang, Hao Huang, Hongwei Jiang, Shaoxian Wu, Yaping Chen, Bin Xu, Yingting Liu, Dawei Zhu, Xiao Zheng, Lujun Chen, Jingting Jiang
Immune checkpoint blockade therapy is a pivotal approach in treating malignant tumors. TIGIT has emerged as a focal point of interest among the diverse targets for tumor immunotherapy. Nonetheless, there is still a lack of comprehensive understanding regarding the immune microenvironment alterations following TIGIT blockade treatment. To bridge this knowledge gap, we performed single-cell sequencing on mice both before and after the administration of anti-TIGIT therapy. Our analysis revealed that TIGIT was predominantly expressed on T cells and natural killer (NK) cells...
March 28, 2024: Journal of Immunotherapy
https://read.qxmd.com/read/38545756/novel-peripheral-blood-mononuclear-cell-mrna-signature-for-ifn-beta-therapy-responsiveness-prediction-in-multiple-sclerosis
#6
JOURNAL ARTICLE
Yang Xue, Pengqi Yin, Hongping Chen, Guozhong Li, Di Zhong
Interferon-beta (IFN-<mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>) is one of the classical drugs for immunomodulatory therapy in relapsing-remitting multiple sclerosis (RRMS) patients, but the drug responsiveness of different patients varies. Currently, there is no valid model to predict IFN-<mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math> responsiveness...
December 2024: Autoimmunity
https://read.qxmd.com/read/38545136/characteristics-of-lymphocyte-subsets-and-inflammatory-factors-in-patients-with-covid-19
#7
JOURNAL ARTICLE
Zixi Chen, Jinpeng Li, Jin Zheng, Fenfen Xiang, Xiaoxiao Li, Mengzhe Zhang, Xiangdong Kang, Rong Wu
OBJECTIVE: This research aims to examine the involvement of lymphocyte subsets and inflammatory cytokines in the development and progression of COVID-19. METHODS: 164 COVID-19 patients were admitted to hospital between December 2022 and January 2023. Based on lung CT scans and whether it is necessary for intensive care unit (ICU) admission, they were categorized into: severe groups (84) and mild disease groups (80). Peripheral blood were also collected from 101 healthy examinees and 164 patients...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38545126/crispr-car-t-and-nk-current-applications-and-future-perspectives
#8
REVIEW
Mohadeseh Khoshandam, Hossein Soltaninejad, Amir Ali Hamidieh, Saman Hosseinkhani
Chimeric antigen receptor T (CAR-T) cell therapy represents a breakthrough in personalized cancer treatments. In this regard, synthetic receptors comprised of antigen recognition domains, signaling, and stimulatory domains are used to reprogram T-cells to target tum or cells and destroy them. Despite the success of this approach in refractory B-cell malignancies, the optimal potency of CAR T-cell therapy for many other cancers, particularly solid tumors, has not been validated. Natural killer cells are powerful cytotoxic lymphocytes specialized in recognizing and dispensing the tumor cells in coordination with other anti-tumor immunity cells...
July 2024: Genes & Diseases
https://read.qxmd.com/read/38545115/therapeutic-approaches-to-enhance-natural-killer-cell-cytotoxicity
#9
REVIEW
Terran D Stenger, Jeffrey S Miller
Enhancing the cytotoxicity of natural killer (NK) cells has emerged as a promising strategy in cancer immunotherapy, due to their pivotal role in immune surveillance and tumor clearance. This literature review provides a comprehensive overview of therapeutic approaches designed to augment NK cell cytotoxicity. We analyze a wide range of strategies, including cytokine-based treatment, monoclonal antibodies, and NK cell engagers, and discuss criteria that must be considered when selecting an NK cell product to combine with these strategies...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38545097/tigit-regulates-cd4-t-cell-immunity-against-polymicrobial-sepsis
#10
JOURNAL ARTICLE
Xuexin Zhong, Haiping Xie, Shuang Wang, Tingting Ren, Junlin Chen, Yuefang Huang, Niansheng Yang
BACKGROUND: Sepsis is one of the major causes of death and increased health care burden in modern intensive care units. Immune checkpoints have been prompted to be key modulators of T cell activation, T cell tolerance and T cell exhaustion. This study was designed to investigate the role of the negative immune checkpoint, T cell immunoglobulin and ITIM domain (TIGIT), in the early stage of sepsis. METHOD: An experimental murine model of sepsis was developed by cecal ligation and puncture (CLP)...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38544569/phenotypic-switching-as-a-non-genetic-mechanism-of-resistance-predicts-antibody-therapy-regimens
#11
JOURNAL ARTICLE
Jiawei Zhou, Can Liu, Yu Tang, Zhongbo Li, Yanguang Cao
Despite the specificity and effectiveness of antibody therapy, resistance to treatment remains a major barrier for their broad clinical applications. While genetic mutations are known to be critical, the impact of non-genetic mechanisms, such as epigenetic changes and phenotypic adaptations, on resistance to antibody-dependent cellular cytotoxicity (ADCC) is not fully understood. Our study investigated the non-genetic resistance mechanisms that colorectal cancer cells develop against cetuximab and the resulting ADCC pressure...
April 19, 2024: IScience
https://read.qxmd.com/read/38544351/quantification-and-molecular-correlates-of-tertiary-lymphoid-structures-in-primary-prostate-cancer
#12
JOURNAL ARTICLE
Mohammed Shahait, Alexander K Hakansson, Reba E Daniel, Kareem Hosny, Elai Davicioni, Seagle Yang Liu, Alex Sandberg, David I Lee, Priti Lal
OBJECTIVE: To morphologically describe tertiary lymphoid structures (TLS) in prostatectomy specimens and correlate them with clinical and transcriptomic features. METHODOLOGY: A total of 72 consecutive cases of entirely submitted radical prostatectomy (RP) patients tested with the Decipher Genomic Classifier were included in the study. Images were manually annotated using QuPath tools to denote tumor regions and each cluster of TLS. Clusters of lymphocytes that were surrounded on all four sides by tumor were defined as intra-tumor TLS (IT-TLS)...
March 27, 2024: Prostate
https://read.qxmd.com/read/38544346/dual-activity-of-type-iii-pi3k-kinase-vps34-is-critical-for-nk-cell-development-and-senescence
#13
JOURNAL ARTICLE
Shasha Chen, Zehua Li, Jin Feng, Yuhe Quan, Junming He, Jiqing Hao, Zhongjun Dong
Vps34 is the unique member of the class III phosphoinositide 3-kinase family that performs both vesicular transport and autophagy. Its role in natural killer (NK) cells remains uncertain. In this study, a model without Vps34 (Vps34fl/fl /CD122Cre/+ ) is generated, deleting Vps34 during and after NK-cell commitment. These mice exhibit a nearly 90% decrease in NK cell count and impaired differentiation. A mechanistic study reveals that the absence of Vps34 disrupts the transport of IL-15 receptor subunit alpha CD122 to the cell membrane, resulting in reduced responsiveness of NK cells to IL-15...
March 27, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38543974/oncolytic-adenovirus-armed-with-a-novel-agonist-of-the-cd137-immune-checkpoint-stimulator-suppresses-tumor-growth
#14
JOURNAL ARTICLE
Martin R Ramos-Gonzalez, Mohammad Tarique, Lalit Batra, Feyza Arguc, Rodolfo Garza-Morales, Haval Shirwan, Esma S Yolcu, Jorge G Gomez-Gutierrez
Natural 4-1BBL (CD137L) is a cell membrane-bound protein critical to the expansion, effector function, and survival of CD8+ T cells. We reported the generation of an active soluble oligomeric construct, SA-4-1BBL, with demonstrated immunoprevention and immunotherapeutic efficacy in various mouse tumor models. Herein, we developed an oncolytic adenovirus (OAd) for the delivery and expression of SA-4-1BBL (OAdSA-4-1BBL) into solid tumors for immunotherapy. SA-4-1BBL protein expressed by this construct produced T-cell proliferation in vitro...
March 21, 2024: Vaccines
https://read.qxmd.com/read/38543837/an-evaluation-of-type-1-interferon-related-genes-in-male-and-female-matched-sars-cov-2-infected-individuals-early-in-the-covid-19-pandemic
#15
JOURNAL ARTICLE
Tom P Huecksteadt, Elizabeth J Myers, Samuel E Aamodt, Shubhanshi Trivedi, Kristi J Warren
SARS-CoV-2 infection has claimed just over 1.1 million lives in the US since 2020. Globally, the SARS-CoV-2 respiratory infection spread to 771 million people and caused mortality in 6.9 million individuals to date. Much of the early literature showed that SARS-CoV-2 immunity was defective in the early stages of the pandemic, leading to heightened and, sometimes, chronic inflammatory responses in the lungs. This lung-associated 'cytokine storm' or 'cytokine release syndrome' led to the need for oxygen supplementation, respiratory distress syndrome, and mechanical ventilation in a relatively high number of people...
March 20, 2024: Viruses
https://read.qxmd.com/read/38543173/sulfarotene-inhibits-colorectal-cancer-via-mitigating-natural-killer-cell-induced-stemness
#16
JOURNAL ARTICLE
Keshu Hu, Yu Dong, Jiayu Zhang, Mengling Liu, Xun Sun, Xin Cao, Pengfei Zhang, Tianshu Liu
Tumor cell stemness stands out as a pivotal factor driving tumor recurrence or metastasis and significantly contributes to the mortality of patients with colorectal cancer (CRC). Recent research has unveiled a link between immune-active cells and the induction of tumor cell stemness, ultimately leading to heightened resistance to treatment. In this study, stemness in CRC cell lines was assessed after co-culture with natural killer (NK) cells, both with and without sulfarotene administration. Furthermore, a CRC xenograft model was utilized to scrutinize the in vivo efficacy of sulfarotene in overcoming stemness induced by NK cell activation...
March 18, 2024: Pharmaceuticals
https://read.qxmd.com/read/38542760/increasing-natural-killer-cell-activity-of-mineral-nanomaterial-alp1018-in-healthy-adults-a-randomized-double-blind-placebo-comparative-clinical-trial
#17
JOURNAL ARTICLE
Soon-Ae Kim, Seyl Kim, Hyungyung Chai, Junlae Cho, Yu-Jin Paek
This randomized, double-blind, placebo comparative clinical trial aimed to determine the immune-enhancing effects and safety of a nanomaterial with iron and zinc (ALP1018) in healthy adults. Participants who met the inclusion criteria were recruited for this study ( n = 80) and randomly assigned to either the test group ( n = 40), which was given Alp1018 in capsule form, or the placebo group ( n = 40), which was given crystal cellulose capsules of identical appearance, weight, and flavor for 8 weeks. Compared to baseline, natural killer (NK) cell activity (%) increased in the test group after 8 weeks, although there were no changes in the placebo group...
March 15, 2024: Nutrients
https://read.qxmd.com/read/38542336/an-estrogen-nk-cells-regulatory-axis-in-endometriosis-related-infertility-and-miscarriage
#18
REVIEW
Shaoliang Yang, Haiyan Wang, Dajin Li, Mingqing Li
Endometriosis is a common estrogen-dependent condition that impacts 8-10% of women in their reproductive age, resulting in notable pain, morbidity, and infertility. Despite extensive research endeavors, the precise cause of endometriosis remains elusive, and the mechanisms contributing to its associated infertility are still not well comprehended. Natural killer (NK) cells, vital innate immune cells crucial for successful pregnancy, have been investigated for their potential involvement in the pathogenesis of endometriosis...
March 16, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541700/in-vitro-study-of-interleukin-6-when-used-at-low-dose-and-ultra-low-dose-in-micro-immunotherapy
#19
JOURNAL ARTICLE
Camille Jacques, Flora Marchand, Mathias Chatelais, Adrien Brulefert, Mathieu Riffault, Ilaria Floris
As one of the major cytokines implicated in the orchestration of immune responses, interleukin 6 (IL-6) can either act as a pro- or an anti-inflammatory factor, depending on the micro-environment. In micro-immunotherapy (MI) medicines, IL-6 is employed at low doses (LD) and ultra-low doses (ULD), expressed in centesimal Hahnemannian (CH), and used alone or in combination with other immune regulators to modulate patients' immune responses. The present study focused on assessing the in vitro immune-modulatory effects of two IL-6-containing MI products: (i) the unitary IL-6 (4 CH) and (ii) the complex MI-medicine (MIM) 2LALERG® , which includes IL-6 (17 CH) in association with other actives in its formulation...
March 12, 2024: Life
https://read.qxmd.com/read/38540320/antibiotic-free-gene-vectors-a-25-year-journey-to-clinical-trials
#20
REVIEW
Corinne Marie, Daniel Scherman
Until very recently, the major use, for gene therapy, specifically of linear or circular DNA, such as plasmids, was as ancillary products for viral vectors' production or as a genetic template for mRNA production. Thanks to targeted and more efficient physical or chemical delivery techniques and to the refinement of their structure, non-viral plasmid DNA are now under intensive consideration as pharmaceutical drugs. Plasmids traditionally carry an antibiotic resistance gene for providing the selection pressure necessary for maintenance in a bacterial host...
February 20, 2024: Genes
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