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https://www.readbyqxmd.com/read/29679487/allergen-specific-immunotherapy-induces-regulatory-t-cells-in-an-atopic-dermatitis-mouse-model
#1
Jung U Shin, Seo Hyeong Kim, Ji Yeon Noh, Ji Hye Kim, Kim Hye Ran, Kyoung Yong Jeong, Kyung Hee Park, Jungsoo Lee, Howard Chu, Jae-Hyun Lee, Tai-Soon Yong, Jung-Won Park, Kwang Hoon Lee
BACKGROUND: Several studies have demonstrated that allergen-specific immunotherapy (SIT) can be an effective treatment for atopic dermatitis (AD). However, there is no relevant mouse model to investigate the mechanism and validate the novel modality of SIT in AD. METHODS: NC/Nga mice with induced AD-like skin lesions received a subcutaneous injection of SIT (an extract of the house dust mite Dermatophagoides farinae [DfE]) or placebo for 5 weeks). Clinical and histological improvements of AD-like skin lesions were examined...
April 21, 2018: Allergy
https://www.readbyqxmd.com/read/29679407/longitudinal-urinary-metabolomic-profiling-reveals-metabolites-for-asthma-development-in-early-childhood
#2
Chih-Yung Chiu, Gigin Lin, Mei-Ling Cheng, Meng-Han Chiang, Ming-Han Tsai, Kuan-Wen Su, Man-Chin Hua, Sui-Ling Liao, Shen-Hao Lai, Tsung-Chieh Yao, Kuo-Wei Yeh, Jing-Long Huang
BACKGROUND: Several metabolites and altered metabolic pathways have been reported to be associated with asthma. However, longitudinal analysis of the dynamics of metabolites contributing to the development of asthma has not yet been fully clarified. METHODS: We sought to identify the metabolic mechanisms underlying asthma development in early childhood. Thirty children with asthma and paired healthy controls from a prospective birth cohort were enrolled. Time-series analysis of urinary metabolites collected at ages 1, 2, 3, and 4 years were assessed using 1 H-nuclear magnetic resonance (NMR) spectroscopy coupled with partial least-squares discriminant analysis (PLS-DA)...
April 21, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29679243/factors-associated-with-the-separate-and-concurrent-experiences-of-food-and-housing-insecurity-among-women-living-with-hiv-in-canada
#3
Carmen H Logie, Ying Wang, Natania Marcus, Angela Kaida, Nadia O'Brien, Val Nicholson, Kath Webster, Tracey Conway, Alexandra de Pokomandy, Mona Loutfy
People living with HIV are disproportionately affected by food and housing insecurity. We assessed factors associated with experiencing food and/or housing insecurity among women living with HIV (WLHIV) in Canada. In our sample of WLHIV (N = 1403) 65% reported an income less than $20,000 per year. Most (78.69%) participants reported food and/or housing insecurity: 27.16% reported experiencing food insecurity alone, 14.26% reported housing insecurity alone, and 37.28% reported experiencing food and housing insecurity concurrently...
April 20, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29679155/antero-vs-retrograde-nerve-dissection-in-parotidectomy-a-systematic-review-and-meta-analysis
#4
Petar Stankovic, Jan Wittlinger, Nina Timmesfeld, Stephan Hoch Stephan, Robert Georgiew, Thomas Günzel, Afshin Teymoortash, Thomas Wilhelm
INTRODUCTION: The retrograde approach (RP) to nerve identification is a method seldom used in parotid surgery. A systematic review comparing this method to the standard anterograde approach (AP) with respect to facial nerve palsy (FNP) does not currently exist. METHODS: In a meta-analysis according to the PRISMA statement, eight publications, including one randomized controlled trial, were selected. The primary aim was to compare the temporary and permanent FNP resulting from the two dissection methods...
April 20, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29679003/the-transcription-repair-coupling-factor-mfd-associates-with-rna-polymerase-in-the-absence-of-exogenous-damage
#5
Han N Ho, Antoine M van Oijen, Harshad Ghodke
During transcription elongation, bacterial RNA polymerase (RNAP) can pause, backtrack or stall when transcribing template DNA. Stalled transcription elongation complexes at sites of bulky lesions can be rescued by the transcription terminator Mfd. The molecular mechanisms of Mfd recruitment to transcription complexes in vivo remain to be elucidated, however. Using single-molecule live-cell imaging, we show that Mfd associates with elongation transcription complexes even in the absence of exogenous genotoxic stresses...
April 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29678993/qualitative-longitudinal-study-of-episodic-disability-experiences-of-older-women-living-with-hiv-in-ontario-canada
#6
Patricia Solomon, Kelly K O'Brien, Stephanie Nixon, Lori Letts, Larry Baxter, Nicole Gervais
OBJECTIVES: To examine the episodic disability experiences of older women living with HIV over time. DESIGN: Qualitative longitudinal study, conducting semistructured in-depth interviews on four occasions over a 20-month time frame. Inductive thematic analyses were conducted cross-sectionally and longitudinally. SETTING: Participants were recruited from HIV community organisations in Canada. PARTICIPANTS: 10 women aged 50 years or older living with HIV for more than 6 years...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678267/comparison-of-recipient-outcomes-after-kidney-transplantation-in-house-versus-imported-deceased-donors
#7
S Y Lim, J G Gwon, M G Kim, C W Jung
BACKGROUND: Increased cold ischemia time in cadaveric kidney transplants has been associated with a high rate of delayed graft function (DGF), and even with graft survival. Kidney transplantation using in-house donors reduces cold preservation time. The purpose of this study was to compare the clinical outcomes after transplantation in house and externally. METHODS: We retrospectively reviewed the medical records of donors and recipients of 135 deceased-donor kidney transplantations performed in our center from March 2009 to March 2016...
April 17, 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29678128/spirpep-an-in-silico-digestion-based-platform-to-assist-bioactive-peptides-discovery-from-a-genome-wide-database
#8
Krittima Anekthanakul, Apiradee Hongsthong, Jittisak Senachak, Marasri Ruengjitchatchawalya
BACKGROUND: Bioactive peptides, including biological sources-derived peptides with different biological activities, are protein fragments that influence the functions or conditions of organisms, in particular humans and animals. Conventional methods of identifying bioactive peptides are time-consuming and costly. To quicken the processes, several bioinformatics tools are recently used to facilitate screening of the potential peptides prior their activity assessment in vitro and/or in vivo...
April 20, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29678119/exchange-sex-among-people-receiving-medical-care-for-hiv-in-the-united-states-medical-monitoring-project-2009-2013
#9
Oluwatosin Olaiya, Lina Nerlander, Christine L Mattson, Linda Beer
Many studies of persons who exchange sex for money or drugs have focused on their HIV acquisition risk, and are often limited to select populations and/or geographical locations. National estimates of exchange sex among people living with HIV (PLWH) who are in medical care, and its correlates, are lacking. To address these gaps, we analyzed data from the Medical Monitoring Project, a surveillance system that produces nationally representative estimates of behavioral and clinical characteristics of PLWH receiving medical care in the United States, to estimate the weighted prevalence of exchange sex overall, and by selected socio-demographic, behavioral and clinical characteristics...
April 20, 2018: AIDS Care
https://www.readbyqxmd.com/read/29677821/tailor-made-electrospun-multilayer-composite-polymer-electrolytes-for-high-performance-lithium-polymer-batteries
#10
Du-Hyun Lim, Anupriya K Haridas, Stelbin Peter Figerez, Prasanth Raghavan, Aleksandar Matic, Jou-Hyeon Ahn
A novel tailor-made multilayer composite polymer electrolyte, consisting of two outer layers of electrospun polyacrylonitrile (PAN) and one inner layer of poly(vinyl acetate) (PVAc)/poly(methyl methacrylate) (PMMA)/poly(ethylene oxide) (PEO) fibrous membrane, was prepared using continuous electrospinning. These membranes, which are made up of fibers with diameters in the nanometer range, were stacked in layers to produce interconnected pores that result in a high porosity. Gel polymer electrolytes (GPEs) were prepared by entrapping a liquid electrolyte (1 M LiPF6 in ethylene carbonate/dimethyl carbonate) in the membranes...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29677705/in-house-validation-and-small-scale-collaborative-study-to-evaluate-analytical-performances-of-multi-mycotoxin-screening-methods-based-on-liquid-chromatography-high-resolution-mass-spectrometry-case-study-fusarium-toxins-in-wheat
#11
Biancamaria Ciasca, Michelangelo Pascale, Valerio Guido Altieri, Francesco Longobardi, Michele Suman, Dante Catellani, Veronica M T Lattanzio
A strong trend toward using highly selective mass spectrometry technologies for screening of multiple mycotoxins has been observed in recent years. In the present study, the process of validation of a multi-mycotoxin screening method based on liquid chromatography high-resolution mass spectrometry method is presented. The method was intended for the simultaneous screening of the major Fusarium toxins (deoxynivalenol, 3- and 15-acetyl deoxynivalenol, T-2 and HT-2 toxins, zearalenone, enniatins A, A1, B, B1, beauvericin) in wheat...
April 20, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29677635/synthesis-and-structure-activity-relationship-of-furoquinolinediones-as-inhibitors-of-tyrosyl-dna-phosphodiesterase-2-tdp2
#12
Le-Mao Yu, Zhu Hu, Yu Chen, Azhar Ravji, Sophia Lopez, Caroline B Plescia, Qian Yu, Hui Yang, Monica Abdelmalak, Sourav Saha, Keli Agama, Evgeny Kiselev, Christophe Marchand, Yves Pommier, Lin-Kun An
Tyrosyl-DNA phosphodiesterase 2 (TDP2) is a recently discovered enzyme specifically repairing topoisomerase II (TOP2)-mediated DNA damage. It has been shown that inhibition of TDP2 synergize with TOP2 inhibitors. Herein, we report the discovery of the furoquinolinedione chemotype as a suitable skeleton for the development of selective TDP2 inhibitors. Compound 1 was identified as a TDP2 inhibitor as a result of screening our in-house compound library for compounds selective for TDP2 vs. TDP1. Further SAR studies provide several selective TDP2 inhibitors at low-micromolar range...
April 12, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29677570/covalently-circularized-nanodiscs-challenges-and-applications
#13
REVIEW
Mahmoud L Nasr, Gerhard Wagner
Covalently circularized nanodiscs (cNDs) represent a significant advance in the durability and applicability of nanodisc technology. The new cNDs demonstrate higher size homogeneity and improved stability compared with that of non-circularized forms. Moreover, cNDs can be prepared at various defined sizes up to 80-nm diameter. The large cNDs can house much larger membrane proteins and their complexes than was previously possible with the conventional nanodiscs. In order to experience the full advantages of covalent circularization, high quality circularized scaffold protein and nanodisc samples are needed...
April 17, 2018: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/29677491/the-allergen-der-p3-from-house-dust-mite-stimulates-store-operated-ca-2-channels-and-mast-cell-migration-through-par4-receptors
#14
Yu-Ping Lin, Charmaine Nelson, Holger Kramer, Anant B Parekh
The house dust mite is the principal source of perennial aeroallergens in man. How these allergens activate innate and adaptive immunity is unclear, and therefore, there are no therapies targeting mite allergens. Here, we show that house dust mite extract activates store-operated Ca2+ channels, a common signaling module in numerous cell types in the lung. Activation of channel pore-forming Orai1 subunits by mite extract requires gating by STIM1 proteins. Although mite extract stimulates both protease-activated receptor type 2 (PAR2) and PAR4 receptors, Ca2+ influx is more tightly coupled to the PAR4 pathway...
April 19, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29676805/concurrent-determination-and-separation-of-inorganic-cations-and-anions-in-microchip-electrophoresis-with-precisely-controlled-high-voltage
#15
Zhe Huang, Mingpeng Yang, Hui You, Yang Xie
An improved method for the concurrent determination and separation of cations and anions by microchip electrophoresis with capacitively coupled contactless conductivity detection (ME-C4 D) is described. Two kinds of microchip structures were designed. The first microchip has a long bent separation channel. And for the defects of the first microchip, the second microchip with a Y-type separation channel has been proposed. The background electrolyte (BGE) composed of 20 mm His/MES and 0.01 mm CTAB was optimized for inhibiting the electroosmotic flow (EOF)...
April 20, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29676689/intravenous-acetaminophen-for-postoperative-supratentorial-craniotomy-pain-a-prospective-randomized-double-blinded-placebo-controlled-trial
#16
Walavan Sivakumar, Michael Jensen, Julie Martinez, Michael Tanana, Nancy Duncan, Robert Hoesch, Jay K Riva-Cambrin, Craig Kilburg, Safdar Ansari, Paul A House
OBJECTIVE Acute pain control after cranial surgery is challenging. Prior research has shown that patients experience inadequate pain control post-craniotomy. The use of oral medications is sometimes delayed because of postoperative nausea, and the use of narcotics can impair the evaluation of brain function and thus are used judiciously. Few nonnarcotic intravenous (IV) analgesics exist. The authors present the results of the first prospective study evaluating the use of IV acetaminophen in patients after elective craniotomy...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676071/differences-in-genetic-variations-between-treatable-and-recalcitrant-atopic-dermatitis-in-korean
#17
Myungsoo Jun, Hye Young Wang, Solam Lee, Eunhee Choi, Hyeyoung Lee, Eung Ho Choi
PURPOSE: Variations in barrier- or immune response-related genes are closely related to the development of atopic dermatitis (AD). This study was designed to identify genetic variations and clinical features to predict 'recalcitrant AD.' METHODS: AD patients were classified as treatable and recalcitrant. Treatable AD patients showed satisfactory clinical improvement with basic and topical treatments. Recalcitrant AD patients used systemic immune-suppressants for over 4 weeks as they had not shown clinical improvement with basic and topical treatments...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29675871/an-evaluation-of-video-cameras-for-collecting-observational-data-on-sanctuary-housed-chimpanzees-pan-troglodytes
#18
Bethany K Hansen, Amy L Fultz, Lydia M Hopper, Stephen R Ross
Video cameras are increasingly being used to monitor captive animals in zoo, laboratory, and agricultural settings. This technology may also be useful in sanctuaries with large and/or complex enclosures. However, the cost of camera equipment and a lack of formal evaluations regarding the use of cameras in sanctuary settings make it challenging for facilities to decide whether and how to implement this technology. To address this, we evaluated the feasibility of using a video camera system to monitor chimpanzees at Chimp Haven...
April 19, 2018: Zoo Biology
https://www.readbyqxmd.com/read/29675412/capacities-for-the-risk-assessment-of-gmos-challenges-to-build-sustainable-systems
#19
Danilo Fernández Ríos, Clara Rubinstein, Carmen Vicién
The need for functional risk assessment bodies in general, and in the biosafety field in particular, demands continued efforts and commitment from regulatory agencies, if results that are sustainable in time are to be achieved. The lack of formal processes that ensure continuity in the application of state of the art scientific criteria, the high rotation in some cases or the lack of experienced professionals, in others, is a challenge to be addressed. Capacity building initiatives with different approaches and degrees of success have been implemented in many countries over the years, supported by diverse governmental and non-governmental organizations...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29675211/high-throughput-reaction-screening-using-desorption-electrospray-ionization-mass-spectrometry
#20
Michael Wleklinski, Bradley P Loren, Christina R Ferreira, Zinia Jaman, Larisa Avramova, Tiago J P Sobreira, David H Thompson, R Graham Cooks
We report the high throughput analysis of reaction mixture arrays using methods and data handling routines that were originally developed for biological tissue imaging. Desorption electrospray ionization (DESI) mass spectrometry (MS) is applied in a continuous on-line process at rates that approach 104 reactions per h at area densities of up to 1 spot per mm2 (6144 spots per standard microtiter plate) with the sprayer moving at ca. 104 microns per s. Data are analyzed automatically by MS using in-house software to create ion images of selected reagents and products as intensity plots in standard array format...
February 14, 2018: Chemical Science
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