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https://www.readbyqxmd.com/read/28532123/origin-of-dislocation-luminescence-centers-and-their-reorganization-in-p-type-silicon-crystal-subjected-to-plastic-deformation-and-high-temperature-annealing
#1
Bohdan Pavlyk, Markiyan Kushlyk, Dmytro Slobodzyan
Changes of the defect structure of silicon p-type crystal surface layer under the influence of plastic deformation and high temperature annealing in oxygen atmosphere were investigated by deep-level capacitance-modulation spectroscopy (DLCMS) and IR spectroscopy of molecules and atom vibrational levels. Special role of dislocations in the surface layer of silicon during the formation of its energy spectrum and rebuilding the defective structure was established. It is shown that the concentration of linear defects (N ≥ 10(4) cm(-2)) enriches surface layer with electrically active complexes (dislocation-oxygen, dislocation-vacancy, and dislocation-interstitial atoms of silicon) which are an effective radiative recombination centers...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28532067/development-of-biocompatible-and-safe-polyethersulfone-hemodialysis-membrane-incorporated-with-functionalized-multi-walled-carbon-nanotubes
#2
Muhammad Nidzhom Zainol Abidin, Pei Sean Goh, Ahmad Fauzi Ismail, Mohd Hafiz Dzarfan Othman, Hasrinah Hasbullah, Noresah Said, Siti Hamimah Sheikh Abdul Kadir, Fatmawati Kamal, Mohd Sohaimi Abdullah, Be Cheer Ng
A novel approach in the design of a safe, high performance hemodialysis membrane is of great demand. Despite many advantages, the employment of prodigious nanomaterials in hemodialysis membrane is often restricted by their potential threat to health. Hence, this work focusses on designing a biocompatible polyethersulfone (PES) hemodialysis membrane embedded with poly (citric acid)-grafted-multi walled carbon nanotubes (PCA-g-MWCNTs). Two important elements which could assure the safety of the nanocomposite membrane, i...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532053/functionalized-fe3o4-graphene-oxide-nanocomposites-with-hairpin-aptamers-for-the-separation-and-preconcentration-of-trace-pb-2-from-biological-samples-prior-to-determination-by-icp-ms
#3
Mojtaba Shamsipur, Leila Farzin, Mahmoud Amouzadeh Tabrizi, Shahab Sheibani
Lead (Pb) as a topically poisonous metal represents a serious threat to the ecological environment and especially to human beings. Therefore, it is urgent to develop a rapid and reliable monitoring technique for this heavy metal in the environmental samples. In the present study, we have designed a selective and sensitive method for the determination of ultratrace contents of Pb(2+) in biological samples, based on the guanine (G)-quadruplex formed by the aptamer with hairpin structure and Pb(2+). For this purpose, Pb(2+) specific aptamer serving as affinity probe to capture and separate trace amounts of the analyte, was covalently linked to Fe3O4/graphene oxide (GO) surface by using a suitable cross-linking agent...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531960/multiple-stress-response-of-lowland-stream-benthic-macroinvertebrates-depends-on-habitat-type
#4
Daniel Graeber, Tinna M Jensen, Jes J Rasmussen, Tenna Riis, Peter Wiberg-Larsen, Annette Baattrup-Pedersen
Worldwide, lowland stream ecosystems are exposed to multiple anthropogenic stress due to the combination of water scarcity, eutrophication, and fine sedimentation. The understanding of the effects of such multiple stress on stream benthic macroinvertebrates has been growing in recent years. However, the interdependence of multiple stress and stream habitat characteristics has received little attention, although single stressor studies indicate that habitat characteristics may be decisive in shaping the macroinvertebrate response...
May 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28531946/the-role-of-mobilisation-and-delivery-processes-on-contrasting-dissolved-nitrogen-and-phosphorus-exports-in-groundwater-fed-catchments
#5
Rémi Dupas, Per-Erik Mellander, Chantal Gascuel-Odoux, Ophélie Fovet, Eoin B McAleer, Noeleen T McDonald, Mairead Shore, Phil Jordan
Diffuse transfer of nitrogen (N) and phosphorus (P) in agricultural catchments is controlled by the mobilisation of sources and their delivery to receiving waters. While plot scale experiments have focused on mobilisation processes, many catchment scale studies have hitherto concentrated on the controls of dominant flow pathways on nutrient delivery. To place mobilisation and delivery at a catchment scale, this study investigated their relative influence on contrasting nitrate-N and soluble P concentrations and N:P ratios in two shallow groundwater fed catchments with different land use (grassland and arable) on the Atlantic seaboard of Europe...
May 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28531914/lineage-specific-expression-of-mir-200-family-in-human-embryonic-stem-cells-during-in-vitro-differentiation
#6
Yeji Kim, Nury Kim, Sang-Wook Park, Hyemin Kim, Han-Jin Park, Yong-Mahn Han
Although microRNAs have emerged as key regulators in diverse cellular processes, the roles of microRNAs are poorly understood in human embryonic stem cells (hESCs) during differentiation into specialized cell types. In this study, we used a microRNA array with 799 human microRNA probes to examine the expression profiles of microRNAs in hESCs during differentiation into endodermal and mesodermal lineages in vitro. Among the microRNAs analyzed, 7 and 20 microRNAs were enriched in the developmental process of hESCs into mesodermal and endodermal lineages, respectively...
May 30, 2017: International Journal of Stem Cells
https://www.readbyqxmd.com/read/28531859/the-role-of-conductive-materials-in-the-start-up-period-of-thermophilic-anaerobic-system
#7
Wangwang Yan, Nan Shen, Yeyuan Xiao, Yun Chen, Faqian Sun, Vinay Kumar Tyagi, Yan Zhou
The major obstacle for thermophilic anaerobic digestion (TAD) is the inhibited microorganism activity and process instability during the start-up period. This study proposed a strategy to accelerate and stabilize the thermophilic reactors start-up via adding conductive materials. The results show that methane production rate in conductive materials supplemented (CMS) reactors was almost two times higher than the control reactors. Caloramator sp., a candidate of electroactive bacteria, was significantly enriched in the carbon nano-tube (CNT) supplemented groups (12...
May 10, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28531791/an-innovative-brioche-enriched-in-protein-and-energy-improves-the-nutritional-status-of-malnourished-nursing-home-residents-compared-to-oral-nutritional-supplement-and-usual-breakfast-farine-project
#8
Virginie Van Wymelbeke, Laurent Brondel, Francis Bon, Isabelle Martin-Pfitzenmeyer, Patrick Manckoundia
BACKGROUND & AIMS: To compare the effects of a 12-week nutritional intervention, in which an innovative protein-and-energy-enriched brioche, an oral nutritional supplement or a usual breakfast were eaten, on food intake and nutritional status in nursing home residents. DESIGN: Three-armed, multicentre, controlled trial. SETTING: Eight nursing homes in Burgundy, France. PARTICIPANTS: Sixty-eight malnourished participants aged between 70 and 99 years old...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531575/enrichment-of-foods-with-vitamin-d-in-greece-needs-and-recommendations
#9
Antonia Karagiannis, Julia Nisiotou, Anargyros Moulas, Anna Challa
No abstract text is available yet for this article.
June 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531452/the-effect-of-glutamine-and-arginine-enriched-nutritional-support-on-quality-of-life-in-head-and-neck-cancer-patients-treated-with-imrt
#10
Sezin Yuce Sari, Gozde Yazici, Deniz Yuce, Erdem Karabulut, Mustafa Cengiz, Gokhan Ozyigit
BACKGROUND AND AIMS: Oral mucositis and esophagitis are common acute toxicities of radiotherapy (RT) for head and neck cancer (HNC). In order to decrease the rates of these toxicities, we compared quality of life in HNC patients that did and did not receive a glutamine and arginine-enriched solution (GAES) during RT. METHODS: A total of 29 patients received intensity-modulated radiotherapy (IMRT); 15 used GAES b.i.d. during the treatment, and a matched cohort of 14 patients did not...
December 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531363/beneficial-effect-of-enriched-air-nitrox-on-bubble-formation-during-scuba-diving-an-open-water-study
#11
Anne-Kathrin Brebeck, Andreas Deussen, Ursula Range, Costantino Balestra, Sinclair Cleveland, Jochen D Schipke
Bubble formation during scuba diving might induce decompression sickness. This prospective randomised and double-blind study included 108 advanced recreational divers (38 females). Fifty-four pairs of divers, 1 breathing air and the other breathing nitrox28 undertook a standardised dive (24 ± 1 msw; 62 ± 5min) in the Red Sea. Venous gas bubbles were counted (Doppler) 30-<45 min (early) and 45-60 min (late) post-dive at jugular, subclavian and femoral sites. Only 7% (air) vs. 11% (air28®) (n.s.) were bubble-free after a dive...
May 21, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28531253/gender-related-prognostic-value-and-genomic-pattern-of-intra-tumor-heterogeneity-ith-in-colorectal-cancer
#12
Jieyun Zhang, Shican Yan, Xiyu Liu, Lu Gan, Zhenhua Wu, Yiwei Gong, Mingzhu Huang, Xiaowei Zhang, Weijian Guo
Intra-tumor heterogeneity (ITH) is crucial in tumorigenesis and resistance to target therapy. Here, we used mutant-allele tumor heterogeneity (MATH) to measure ITH based on next-generation sequencing data and high MATH was proven as an independent risk prognostic factor in male CRC patients in both a training set of 284 colorectal cancer (CRC) patients with from The Cancer Genome Atlas (TCGA) and a validating set of 187 CRC patients from International Cancer Genome Consortium (ICGC). Further, the genomic pattern according to MATH demonstrated that mutation rates of TP53, IRF5 and KRAS were independently associated with MATH, and the latter two were only significant in male patients...
May 20, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28531236/psychosine-enhances-the-shedding-of-membrane-microvesicles-implications-in-demyelination-in-krabbe-s-disease
#13
Ludovic D'Auria, Cory Reiter, Emma Ward, Ana Lis Moyano, Michael S Marshall, Duc Nguyen, Giuseppe Scesa, Zane Hauck, Richard van Breemen, Maria I Givogri, Ernesto R Bongarzone
In prior studies, our laboratory showed that psychosine accumulates and disrupts lipid rafts in brain membranes of Krabbe's disease. A model of lipid raft disruption helped explaining psychosine's effects on several signaling pathways important for oligodendrocyte survival and differentiation but provided more limited insight in how this sphingolipid caused demyelination. Here, we have studied how this cationic inverted coned lipid affects the fluidity, stability and structure of myelin and plasma membranes...
2017: PloS One
https://www.readbyqxmd.com/read/28531227/different-microrna-profiles-reveal-the-diverse-outcomes-induced-by-ev71-and-ca16-infection-in-human-umbilical-vein-endothelial-cells-using-high-throughput-sequencing
#14
Jie Song, Yajie Hu, Jiaqi Li, Huiwen Zheng, Jingjing Wang, Lei Guo, Ruotong Ning, Hongzhe Li, Zening Yang, Haitao Fan, Longding Liu
Enterovirus 71 (EV71) and Coxsackievirus A16 (CA16) remain the predominant pathogens in hand, foot, and mouth disease (HFMD), but the factors underlying the pathogenesis of EV71 and CA16 infections have not been elucidated. Recently, the functions of microRNAs (miRNAs) in pathogen-host interactions have been highlighted. In the present study, we performed comprehensive miRNA profiling in EV71- and CA16-infected human umbilical vein endothelial cells (HUVECs) at multiple time points using high-throughput sequencing...
2017: PloS One
https://www.readbyqxmd.com/read/28531200/discovery-of-micrornas-during-early-spermatogenesis-in-chicken
#15
Lu Xu, Qixin Guo, Guobin Chang, Lingling Qiu, Xiangping Liu, Yulin Bi, Yu Zhang, Hongzhi Wang, Wei Lu, Lichen Ren, Ying Chen, Yang Zhang, Qi Xu, Guohong Chen
Spermatogenesis is a complex process that involves many elements. However, until now, little is known at the molecular level about spermatogenesis in poultry. Here we investigated microRNAs and their target genes that may be involved in germ cell development and spermatogonial in chicken. We used next-generation sequencing to analyze miRNA expression profiles in three types of germline cells: primordial germ cells (PGCs), spermatogonial stem cells (SSCs), and spermatogonia (Sp) during early stage of spermatogenesis...
2017: PloS One
https://www.readbyqxmd.com/read/28530713/bach2-immunodeficiency-illustrates-an-association-between-super-enhancers-and-haploinsufficiency
#16
Behdad Afzali, Juha Grönholm, Jana Vandrovcova, Charlotte O'Brien, Hong-Wei Sun, Ine Vanderleyden, Fred P Davis, Ahmad Khoder, Yu Zhang, Ahmed N Hegazy, Alejandro V Villarino, Ira W Palmer, Joshua Kaufman, Norman R Watts, Majid Kazemian, Olena Kamenyeva, Julia Keith, Anwar Sayed, Dalia Kasperaviciute, Michael Mueller, Jason D Hughes, Ivan J Fuss, Mohammed F Sadiyah, Kim Montgomery-Recht, Joshua McElwee, Nicholas P Restifo, Warren Strober, Michelle A Linterman, Paul T Wingfield, Holm H Uhlig, Rahul Roychoudhuri, Timothy J Aitman, Peter Kelleher, Michael J Lenardo, John J O'Shea, Nichola Cooper, Arian D J Laurence
The transcriptional programs that guide lymphocyte differentiation depend on the precise expression and timing of transcription factors (TFs). The TF BACH2 is essential for T and B lymphocytes and is associated with an archetypal super-enhancer (SE). Single-nucleotide variants in the BACH2 locus are associated with several autoimmune diseases, but BACH2 mutations that cause Mendelian monogenic primary immunodeficiency have not previously been identified. Here we describe a syndrome of BACH2-related immunodeficiency and autoimmunity (BRIDA) that results from BACH2 haploinsufficiency...
May 22, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28530678/the-complex-genetics-of-hypoplastic-left-heart-syndrome
#17
Xiaoqin Liu, Hisato Yagi, Shazina Saeed, Abha S Bais, George C Gabriel, Zhaohan Chen, Kevin A Peterson, You Li, Molly C Schwartz, William T Reynolds, Manush Saydmohammed, Brian Gibbs, Yijen Wu, William Devine, Bishwanath Chatterjee, Nikolai T Klena, Dennis Kostka, Karen L de Mesy Bentley, Madhavi K Ganapathiraju, Phillip Dexheimer, Linda Leatherbury, Omar Khalifa, Anchit Bhagat, Maliha Zahid, William Pu, Simon Watkins, Paul Grossfeld, Stephen A Murray, George A Porter, Michael Tsang, Lisa J Martin, D Woodrow Benson, Bruce J Aronow, Cecilia W Lo
Congenital heart disease (CHD) affects up to 1% of live births. Although a genetic etiology is indicated by an increased recurrence risk, sporadic occurrence suggests that CHD genetics is complex. Here, we show that hypoplastic left heart syndrome (HLHS), a severe CHD, is multigenic and genetically heterogeneous. Using mouse forward genetics, we report what is, to our knowledge, the first isolation of HLHS mutant mice and identification of genes causing HLHS. Mutations from seven HLHS mouse lines showed multigenic enrichment in ten human chromosome regions linked to HLHS...
May 22, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28530660/endoglin-prevents-vascular-malformation-by-regulating-flow-induced-cell-migration-and-specification-through-vegfr2-signalling
#18
Yi Jin, Lars Muhl, Mikhail Burmakin, Yixin Wang, Anne-Claire Duchez, Christer Betsholtz, Helen M Arthur, Lars Jakobsson
Loss-of-function (LOF) mutations in the endothelial cell (EC)-enriched gene endoglin (ENG) cause the human disease hereditary haemorrhagic telangiectasia-1, characterized by vascular malformations promoted by vascular endothelial growth factor A (VEGFA). How ENG deficiency alters EC behaviour to trigger these anomalies is not understood. Mosaic ENG deletion in the postnatal mouse rendered Eng LOF ECs insensitive to flow-mediated venous to arterial migration. Eng LOF ECs retained within arterioles acquired venous characteristics and secondary ENG-independent proliferation resulting in arteriovenous malformation (AVM)...
May 22, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28530657/normal-and-cancerous-mammary-stem-cells-evade-interferon-induced-constraint-through-the-mir-199a-lcor-axis
#19
Toni Celià-Terrassa, Daniel D Liu, Abrar Choudhury, Xiang Hang, Yong Wei, Jose Zamalloa, Raymundo Alfaro-Aco, Rumela Chakrabarti, Yi-Zhou Jiang, Bong Ihn Koh, Heath A Smith, Christina DeCoste, Jun-Jing Li, Zhi-Ming Shao, Yibin Kang
Tumour-initiating cells, or cancer stem cells (CSCs), possess stem-cell-like properties observed in normal adult tissue stem cells. Normal and cancerous stem cells may therefore share regulatory mechanisms for maintaining self-renewing capacity and resisting differentiation elicited by cell-intrinsic or microenvironmental cues. Here, we show that miR-199a promotes stem cell properties in mammary stem cells and breast CSCs by directly repressing nuclear receptor corepressor LCOR, which primes interferon (IFN) responses...
May 22, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28530613/combination-of-solvent-extractants-for-dispersive-liquid-liquid-microextraction-of-fungicides-from-water-and-fruit-samples-by-liquid-chromatography-with-tandem-mass-spectrometry
#20
Marta Pastor-Belda, Isabel Garrido, Natalia Campillo, Pilar Viñas, Pilar Hellín, Pilar Flores, José Fenoll
A multiresidue method was developed to determine twenty-five fungicides belonging to three different chemical families, oxazoles, strobilurins and triazoles, in water and fruit samples, using dispersive liquid-liquid microextraction (DLLME) and liquid chromatography/tandem mass spectrometry (LC-MS(2)). Solid-liquid extraction with acetonitrile was used for the analysis in fruits, the extract being used as dispersant solvent in DLLME. Since some of the analytes showed high affinity for chloroform and the others were more efficiently extracted with undecanol, a mixture of both solvents was used as extractant in DLLME...
October 15, 2017: Food Chemistry
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