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https://www.readbyqxmd.com/read/28227858/compensation-of-pulsation-artifacts-during-optical-imaging-with-and-without-cranial-chamber
#1
Alejandro Romero-Santiago, Philipp Flotho, Karsten Schwerdtfeger, Jacek Szczygielski, Matthias Hulser, Lars Haab, Daniel J Strauss, Alejandro Romero-Santiago, Philipp Flotho, Karsten Schwerdtfeger, Jacek Szczygielski, Matthias Hulser, Lars Haab, Daniel J Strauss, Daniel J Strauss, Alejandro Romero-Santiago, Jacek Szczygielski, Karsten Schwerdtfeger, Philipp Flotho, Lars Haab, Matthias Hulser
Functional Optical Imaging (OI) through the opened skull forms a group of Neuroimaging techniques characterized by a high temporal and spatial resolution on a meso-to macroscopic scale. State of the art OI experiments are generally difficult to execute, with a very timely surgical preparation preceding the experiment, that requires a skilled surgeon to mount a sealed imaging chamber onto the skull. The chamber reduces brain pulsation artifacts and swelling of the brain through movement restriction. In this work, we present preliminary results of a novel approach that does not rely on the usage of an imaging chamber with the goal to facilitate heavily the surgical animal preparation and to allow straightforward joint Electroencephalography - Optical Imaging recordings in the future...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227825/real-time-autonomous-bladder-event-classification-and-closed-loop-control-from-single-channel-pressure-data
#2
Robert Karam, Swarup Bhunia, Steve Majerus, Steven W Brose, Margot S Damaser, Dennis Bourbeau, Robert Karam, Swarup Bhunia, Steve Majerus, Steven W Brose, Margot S Damaser, Dennis Bourbeau, Steve Majerus, Margot S Damaser, Robert Karam, Steven W Brose, Dennis Bourbeau, Swarup Bhunia
Urinary incontinence, or the loss of bladder control, is a debilitating condition affecting millions worldwide, which significantly reduces quality of life. Neuromodulation of lower urinary tract nerves can be used to treat sensations of urgency in many subjects, including those with Spinal Cord Injury (SCI). Event driven, or conditional stimulation has been investigated as a possible improvement to the state-of-the-art open-loop stimulation systems available today. However, this requires a robust, adaptive, and noise-tolerant method of classifying bladder function from real-time bladder pressure measurements...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227757/feasibility-study-for-the-assessment-of-cardio-respiratory-coupling-in-newborn-infants
#3
Maristella Lucchini, William P Fifer, Manuela Ferrario, Maria G Signorini, Maristella Lucchini, William P Fifer, Manuela Ferrario, Maria G Signorini, Maristella Lucchini, Maria G Signorini, William P Fifer, Manuela Ferrario
Cardio Respiratory Coupling (CRC) plays a key role during infant development. Nonetheless, mechanisms underlying it are still mostly unexplained and tools to assess it are often inadequate to understand its functioning. This study aims to evaluate the feasibility of CRC activity detection and quantification analyzing ECG and respiration of newborn healthy subjects. Cross-spectral analysis (coherence) and a novel application of a nonlinear method (Bivariate Phase Rectified Signal Averaging) were applied on 10 minutes recording from 4 subjects...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227515/a-clinic-compatible-open-source-electrophysiology-system
#4
John Hermiz, Nick Rogers, Erik Kaestner, Mehran Ganji, Dan Cleary, Joseph Snider, David Barba, Shadi Dayeh, Eric Halgren, Vikash Gilja, John Hermiz, Nick Rogers, Erik Kaestner, Mehran Ganji, Dan Cleary, Joseph Snider, David Barba, Shadi Dayeh, Eric Halgren, Vikash Gilja, Erik Kaestner, Mehran Ganji, David Barba, Joseph Snider, Nick Rogers, Shadi Dayeh, Eric Halgren, Vikash Gilja, Dan Cleary, John Hermiz
Open source electrophysiology (ephys) recording systems have several advantages over commercial systems such as customization and affordability enabling more researchers to conduct ephys experiments. Notable open source ephys systems include Open-Ephys, NeuroRighter and more recently Willow, all of which have high channel count (64+), scalability, and advanced software to develop on top of. However, little work has been done to build an open source ephys system that is clinic compatible, particularly in the operating room where acute human electrocorticography (ECoG) research is performed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227501/feasibility-of-a-chronic-minimally-invasive-endovascular-neural-interface
#5
Nicholas L Opie, Gil S Rind, Sam E John, Stephen M Ronayne, David B Grayden, Anthony N Burkitt, Clive N May, Terence J O'Brien, Thomas J Oxley, Nicholas L Opie, Gil S Rind, Sam E John, Stephen M Ronayne, David B Grayden, Anthony N Burkitt, Clive N May, Terence J O'Brien, Thomas J Oxley, Sam E John, Stephen M Ronayne, David B Grayden, Nicholas L Opie, Anthony N Burkitt, Terence J O'Brien, Clive N May, Thomas J Oxley, Gil S Rind
Development of a neural interface that can be implanted without risky, open brain surgery will increase the safety and viability of chronic neural recording arrays. We have developed a minimally invasive surgical procedure and an endovascular electrode-array that can be delivered to overlie the cortex through blood vessels. Here, we describe feasibility of the endovascular interface through electrode viability, recording potential and safety. Electrochemical impedance spectroscopy demonstrated that electrode impedance was stable over 91 days and low frequency phase could be used to infer electrode incorporation into the vessel wall...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227343/application-of-a-new-robust-ecg-t-wave-delineation-algorithm-for-the-evaluation-of-the-autonomic-innervation-of-the-myocardium
#6
Matteo Cesari, Jesper Mehlsen, Anne-Birgitte Mehlsen, Helge Bjarup Dissing Sorensen, Matteo Cesari, Jesper Mehlsen, Anne-Birgitte Mehlsen, Helge Bjarup Dissing Sorensen, Jesper Mehlsen, Helge Bjarup Dissing Sorensen, Matteo Cesari, Anne-Birgitte Mehlsen
T-wave amplitude (TWA) is a well know index of the autonomic innervation of the myocardium. However, until now it has been evaluated only manually or with simple and inefficient algorithms. In this paper, we developed a new robust single-lead electrocardiogram (ECG) T-wave delineation algorithm that is able to detect the T-wave with a wavelet based method and automatically calculate the TWA. We evaluated the algorithm on the QT database, achieving a sensitivity of 99.92% for the T wave peak and 99.38% for the T wave end...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227072/short-term-assessment-of-autonomic-nervous-system-as-a-potential-tool-to-quantify-pain-experience
#7
Arto J Hautala, Jaro Karppinen, Tapio Seppanen, Arto J Hautala, Jaro Karppinen, Tapio Seppanen, Jaro Karppinen, Arto J Hautala, Tapio Seppanen
Various pain conditions may result in altered autonomic nervous system regulation. We evaluated whether autonomic regulation, analyzed with short-term heart rate variability (HRV), differs between low back pain (LBP) patients and healthy controls. Additionally, we tested if short-term HRV recordings are feasible and informative in planning home monitoring of LBP patients. The study population consisted of 16 volunteers (8 LBP patients and 8 healthy subjects) (age 42±10 years, body mass index 26±4 kg/m(2), 7 men and 9 women)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227036/using-i2b2-to-bootstrap-rural-health-analytics-and-learning-networks
#8
Daniel R Harris, Adam D Baus, Tamela J Harper, Traci D Jarrett, Cecil R Pollard, Jeffery C Talbert, Daniel R Harris, Adam D Baus, Tamela J Harper, Traci D Jarrett, Cecil R Pollard, Jeffery C Talbert, Jeffery C Talbert, Daniel R Harris, Traci D Jarrett, Tamela J Harper, Adam D Baus, Cecil R Pollard
We demonstrate that the open-source i2b2 (Informatics for Integrating Biology and the Bedside) data model can be used to bootstrap rural health analytics and learning networks. These networks promote communication and research initiatives by providing the infrastructure necessary for sharing data and insights across a group of healthcare and research partners. Data integration remains a crucial challenge in connecting rural healthcare sites with a common data sharing and learning network due to the lack of interoperability and standards within electronic health records...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226674/a-multiple-kernel-learning-approach-for-human-behavioral-task-classification-using-stn-lfp-signal
#9
Hosein M Golshan, Adam O Hebb, Sara J Hanrahan, Joshua Nedrud, Mohammad H Mahoor, Hosein M Golshan, Adam O Hebb, Sara J Hanrahan, Joshua Nedrud, Mohammad H Mahoor, Joshua Nedrud, Adam O Hebb, Sara J Hanrahan, Mohammad H Mahoor, Hosein M Golshan
Deep Brain Stimulation (DBS) has gained increasing attention as an effective method to mitigate Parkinson's disease (PD) disorders. Existing DBS systems are open-loop such that the system parameters are not adjusted automatically based on patient's behavior. Classification of human behavior is an important step in the design of the next generation of DBS systems that are closed-loop. This paper presents a classification approach to recognize such behavioral tasks using the subthalamic nucleus (STN) Local Field Potential (LFP) signals...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226663/predicting-seizures-in-untreated-temporal-lobe-epilepsy-using-point-process-nonlinear-models-of-heartbeat-dynamics
#10
G Valenza, A Romigi, L Citi, F Placidi, F Izzi, M Albanese, E P Scilingo, M G Marciani, A Duggento, M Guerrisi, N Toschi, R Barbieri, G Valenza, A Romigi, L Citi, F Placidi, F Izzi, M Albanese, E P Scilingo, M G Marciani, A Duggento, M Guerrisi, N Toschi, R Barbieri, M Guerrisi, F Izzi, F Placidi, A Romigi, E P Scilingo, A Duggento, M Albanese, N Toschi, M G Marciani, R Barbieri, G Valenza, L Citi
Symptoms of temporal lobe epilepsy (TLE) are frequently associated with autonomic dysregulation, whose underlying biological processes are thought to strongly contribute to sudden unexpected death in epilepsy (SUDEP). While abnormal cardiovascular patterns commonly occur during ictal events, putative patterns of autonomic cardiac effects during pre-ictal (PRE) periods (i.e. periods preceding seizures) are still unknown. In this study, we investigated TLE-related heart rate variability (HRV) through instantaneous, nonlinear estimates of cardiovascular oscillations during inter-ictal (INT) and PRE periods...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226625/visual-transparent-visual-occlusion-an-eeg-and-cop-study
#11
Kwang Leng Goh, Susan Morris, Wee Lih Lee, Alexander Ring, Tele Tan, Kwang Leng Goh, Susan Morris, Wee Lih Lee, Alexander Ring, Tele Tan, Tele Tan, Kwang Leng Goh, Susan Morris, Alexander Ring, Wee Lih Lee
Electroencephalography (EEG) and centre of pressure (COP) data were recorded in young adults for 60 seconds during standing in visual transparent (VT) and visual occlusion (VO) conditions. In both of these conditions, participants wore VO liquid crystal spectacles which allowed the experimenter to accurately control visual information being presented or occluded to the participant. Alpha band (8-13 Hz) revealed significant differences in channel-averaged power spectrum in these two conditions, but not theta band (4-8 Hz) and beta band (13-30 Hz)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226583/recent-machine-learning-advancements-in-sensor-based-mobility-analysis-deep-learning-for-parkinson-s-disease-assessment
#12
Bjoern M Eskofier, Sunghoon I Lee, Jean-Francois Daneault, Fatemeh N Golabchi, Gabriela Ferreira-Carvalho, Gloria Vergara-Diaz, Stefano Sapienza, Gianluca Costante, Jochen Klucken, Thomas Kautz, Paolo Bonato, Bjoern M Eskofier, Sunghoon I Lee, Jean-Francois Daneault, Fatemeh N Golabchi, Gabriela Ferreira-Carvalho, Gloria Vergara-Diaz, Stefano Sapienza, Gianluca Costante, Jochen Klucken, Thomas Kautz, Paolo Bonato, Fatemeh N Golabchi, Gianluca Costante, Gloria Vergara-Diaz, Paolo Bonato, Gabriela Ferreira-Carvalho, Jean-Francois Daneault, Bjoern M Eskofier, Jochen Klucken, Sunghoon I Lee, Thomas Kautz, Stefano Sapienza
The development of wearable sensors has opened the door for long-term assessment of movement disorders. However, there is still a need for developing methods suitable to monitor motor symptoms in and outside the clinic. The purpose of this paper was to investigate deep learning as a method for this monitoring. Deep learning recently broke records in speech and image classification, but it has not been fully investigated as a potential approach to analyze wearable sensor data. We collected data from ten patients with idiopathic Parkinson's disease using inertial measurement units...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226493/towards-an-unsupervised-device-for-the-diagnosis-of-childhood-pneumonia-in-low-resource-settings-automatic-segmentation-of-respiratory-sounds
#13
J Sola, F Braun, E Muntane, C Verjus, M Bertschi, F Hugon, S Manzano, M Benissa, A Gervaix, J Sola, F Braun, E Muntane, C Verjus, M Bertschi, F Hugon, S Manzano, M Benissa, A Gervaix, F Hugon, C Verjus, A Gervaix, S Manzano, M Bertschi, E Muntane, M Benissa, J Sola, F Braun
Pneumonia remains the worldwide leading cause of children mortality under the age of five, with every year 1.4 million deaths. Unfortunately, in low resource settings, very limited diagnostic support aids are provided to point-of-care practitioners. Current UNICEF/WHO case management algorithm relies on the use of a chronometer to manually count breath rates on pediatric patients: there is thus a major need for more sophisticated tools to diagnose pneumonia that increase sensitivity and specificity of breath-rate-based algorithms...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226421/opening-plenary-speaker-human-genomics-precision-medicine-and-advancing-human-health
#14
Eric D Green
Starting with the launch of the Human Genome Project in 1990, the past quarter-century has brought spectacular achievements in genomics that dramatically empower the study of human biology and disease. The human genomics enterprise is now in the midst of an important transition, as the growing foundation of genomic knowledge is being used by researchers and clinicians to tackle increasingly complex problems in biomedicine. Of particular prominence is the use of revolutionary new DNA sequencing technologies for generating prodigious amounts of DNA sequence data to elucidate the complexities of genome structure, function, and evolution, as well as to unravel the genomic bases of rare and common diseases...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225459/it-is-time-to-cancel-medicine-s-social-contract-metaphor
#15
John M Harris
There is agreement that the complex relationship between medicine and society is best described as a metaphorical social contract and that professionalism is the medical profession's contribution to this contract. Metaphors can help clarify abstract concepts, but they can also be abused if the counterfactual attributes of a metaphor become attributed to its subject. This seems to be happening with medical professionalism, which has sometimes been reduced to a contracted deliverable and a bargaining chip. The undesirable attributes of the social contract metaphor may be hindering efforts to understand and teach medical professionalism...
February 21, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28224110/comparison-of-inhaled-milrinone-nitric-oxide-and-prostacyclin-in-acute-respiratory-distress-syndrome
#16
Martin Albert, Daniel Corsilli, David R Williamson, Marc Brosseau, Patrick Bellemare, Stéphane Delisle, Anne Qn Nguyen, France Varin
AIM: To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome (ARDS). METHODS: Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of iNO (20 ppm) or nebulized epoprostenol (10 μg/mL) was done in all patients...
February 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28223957/eeg-brain-activity-in-dynamic-health-qigong-training-same-effects-for-mental-practice-and-physical-training
#17
Diana Henz, Wolfgang I Schöllhorn
In recent years, there has been significant uptake of meditation and related relaxation techniques, as a means of alleviating stress and fostering an attentive mind. Several electroencephalogram (EEG) studies have reported changes in spectral band frequencies during Qigong meditation indicating a relaxed state. Much less is reported on effects of brain activation patterns induced by Qigong techniques involving bodily movement. In this study, we tested whether (1) physical Qigong training alters EEG theta and alpha activation, and (2) mental practice induces the same effect as a physical Qigong training...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28223211/sensitizing-exposure-to-amphetamine-increases-ampa-receptor-phosphorylation-without-increasing-cell-surface-expression-in-the-rat-nucleus-accumbens
#18
Qiang Wang, Dongdong Li, Nancy Bubula, Matthew R Campioni, Daniel S McGehee, Paul Vezina
Exposure to psychostimulants like cocaine or amphetamine leads to long-lasting sensitization of their behavioral and neurochemical effects. Here we characterized changes in AMPA receptor distribution and phosphorylation state in the rat nucleus accumbens (NAcc) weeks after amphetamine exposure to assess their potential contribution to sensitization by this drug. Using protein cross-linking, biochemical, subcellular fractionation, and slice electrophysiological approaches in the NAcc, we found that, unlike cocaine, previous exposure to amphetamine did not increase cell surface levels of either GluA1 or GluA2 AMPA receptor subunits, redistribution of these subunits to the synaptic or perisynaptic cellular membrane domains, protein-protein associations required to support the accumulation and retention of AMPA receptors in the PSD, or the peak amplitude of AMPA receptor mediated mEPSCs recorded in NAcc slices...
February 18, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28222947/comparison-of-the-effectiveness-of-three-different-treatment-methods-for-temporomandibular-joint-disc-displacement-without-reduction
#19
U Tatli, M E Benlidayi, O Ekren, F Salimov
The aim of this study was to compare the effectiveness of three treatment methods for unilateral temporomandibular joint (TMJ) disc displacement without reduction (DDwoR). One hundred and twenty patients with unilateral TMJ DDwoR were assigned randomly to one of three treatment groups (40 patients in each): group 1 received arthrocentesis, group 2 received stabilization splint therapy following arthrocentesis, and group 3 received splint therapy only. The groups were compared in terms of pain (visual analogue scale), joint function (maximum mouth opening and laterotrusive movements), disability and psychological status (validated questionnaire), and success rates...
February 17, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28222678/tracheal-extubation-in-deeply-anesthetized-pediatric-patients-after-tonsillectomy-a-comparison-of-high-concentration-sevoflurane-alone-and-low-concentration-sevoflurane-in-combination-with-dexmedetomidine-pre-medication
#20
Meiqin Di, Yuan Han, Zhuqing Yang, Huacheng Liu, Xuefei Ye, Hongyan Lai, Jun Li, Wangning ShangGuan, Qingquan Lian
BACKGROUND: Dexmedetomidine can facilitate a smooth extubation process and reduce the requirement of sevoflurane and emergence agitation when administrated perioperatively. We aimed to observe the extubation process and the recovery characteristics in pediatric patients undergoing tonsillectomy while anesthetized with either high-concentration sevoflurane alone or low-concentration sevoflurane combined with pre-medication of single dose of intravenous dexmedetomidine. METHODS: Seventy-five patients (ASA I or II, aged 3-7 years) undergoing tonsillectomy were randomized into three equal groups: to receive intravenous saline (Group D0), dexmedetomidine 1 μg/kg (Group D1), or dexmedetomidine 2 μg/kg (Group D2) approximately 10 min before anesthesia...
February 21, 2017: BMC Anesthesiology
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