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https://www.readbyqxmd.com/read/28813772/pilot-study-to-determine-safety-and-efficacy-of-paclitaxel-infusion-in-de-novo-peripheral-lesions-using-the-atrium-clearway-balloon
#1
Joseph Anderson, Laura Danielson, Jodan Anderson, Katie Pohlson, Tyler Remund, Chad Laurich, Greg Schultz, Angelo Santos, Gopinath Mani, Patrick Kelly, Andrea Shermann
OBJECTIVE: To evaluate the safety and efficacy of a one-time infusion of paclitaxel through an Atrium ClearWay balloon in infra inguinal de novo peripheral lesions. METHODS: This is a single-center prospective study looking at treatment of 50 limbs. Treatment includes standard infra inguinal endovascular revascularization followed by a pre-prescribed infusion of paclitaxel. Control is standard reintervention without subsequent paclitaxel infusion. Patients were followed at one, four, and 10 months with ankle-brachial index (ABI)s, arterial duplex of the treated limb, and Rutherford classification stage measured before and after procedures and at each follow-up...
March 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28812741/persistent-tropical-foraging-in-the-highlands-of-terminal-pleistocene-holocene-new-guinea
#2
Patrick Roberts, Dylan Gaffney, Julia Lee-Thorp, Glenn Summerhayes
The terminal Pleistocene/Holocene boundary (approximately 12-8 thousand years ago) represented a major ecological threshold for humans, both as a significant climate transition and due to the emergence of agriculture around this time. In the highlands of New Guinea, climatic and environmental changes across this period have been highlighted as potential drivers of one of the earliest domestication processes in the world. We present a terminal Pleistocene/Holocene palaeoenvironmental record (12-0 thousand years ago ) of carbon and oxygen isotopes in small mammal tooth enamel from the site of Kiowa...
February 6, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28811582/a-new-class-of-hybrid-secretion-system-is-employed-in-pseudomonas-amyloid-biogenesis
#3
Sarah L Rouse, William J Hawthorne, Jamie-Lee Berry, Dror S Chorev, Sandra A Ionescu, Sebastian Lambert, Fisentzos Stylianou, Wiebke Ewert, Uma Mackie, R Marc L Morgan, Daniel Otzen, Florian-Alexander Herbst, Per H Nielsen, Morten Dueholm, Hagan Bayley, Carol V Robinson, Stephen Hare, Stephen Matthews
Gram-negative bacteria possess specialised biogenesis machineries that facilitate the export of amyloid subunits for construction of a biofilm matrix. The secretion of bacterial functional amyloid requires a bespoke outer-membrane protein channel through which unfolded amyloid substrates are translocated. Here, we combine X-ray crystallography, native mass spectrometry, single-channel electrical recording, molecular simulations and circular dichroism measurements to provide high-resolution structural insight into the functional amyloid transporter from Pseudomonas, FapF...
August 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28811061/surgical-demographics-of-carpal-tunnel-syndrome-and-cubital-tunnel-syndrome-over-5-years-at-a-single-institution
#4
Dafang Zhang, Jamie E Collins, Brandon E Earp, Philip Blazar
PURPOSE: Carpal tunnel and cubital tunnel syndrome are the 2 most common upper-limb compressive neuropathies. However, whether the characteristics of patient populations undergoing surgery for these conditions are similar is unclear in terms of demographics and concomitant pathologies. Our null hypothesis was that there are no identifiable differences between these patient populations. METHODS: A retrospective cohort study was performed by billing system query using Common Procedural Terminology (CPT) codes for all patients who underwent open carpal tunnel release (CTR) (CPT code 64721) and/or open cubital tunnel surgery (CPT code 64718) by 1 of 4 hand surgeons from August 2008 to July 2013...
August 12, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28810721/de-novo-low-dose-sirolimus-versus-mycophenolate-mofetil-in-combination-with-extended-release-tacrolimus-in-kidney-transplant-recipients-a-multicentre-open-label-randomized-controlled-non-inferiority-trial
#5
Kyu Ha Huh, Jae Geun Lee, Jongwon Ha, Chang-Kwon Oh, Man Ki Ju, Chan-Duck Kim, Hong Rae Cho, Cheol Woong Jung, Beom Jin Lim, Yu Seun Kim
Background: Most of the previous studies reported that tacrolimus (TAC) with sirolimus (SRL) was associated with worse post-transplant outcomes in kidney transplantation, compared with TAC with mycophenolate mofetil (MMF). These might be attributable to high-dose SRL. However, outcomes using low-dose SRL with TAC for kidney transplantation are uncertain. The aim of this study was to assess the efficacy and safety of low-dose SRL with extended-release tacrolimus (ER-TAC) versus MMF with ER-TAC...
August 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28810689/temporal-trends-in-airborne-dust-concentrations-at-a-large-chrysotile-mine-and-its-asbestos-enrichment-factories-in-the-russian-federation-during-1951-2001
#6
Sara J Schonfeld, Evgeny V Kovalevskiy, Eleonora Feletto, Igor V Bukhtiyarov, Sergey V Kashanskiy, Monika Moissonier, Kurt Straif, Valerie A McCormack, Joachim Schüz, Hans Kromhout
Objectives: Mining and processing of chrysotile, an established carcinogen, has been undertaken in Asbest, Russian Federation since the late 1800s. Dust concentrations were routinely recorded at the open-pit mine and its asbestos-enrichment factories. We examined the temporal trends in these dust concentrations from 1951 to 2001. Methods: Analyses included 89290 monthly averaged gravimetric dust concentrations in six factories (1951-2001) and 1457 monthly averaged concentrations in the mine (1964-2001)...
August 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28809834/quantifying-infra-slow-dynamics-of-spectral-power-and-heart-rate-in-sleeping-mice
#7
Laura M J Fernandez, Sandro Lecci, Romain Cardis, Gil Vantomme, Elidie Béard, Anita Lüthi
Three vigilance states dominate mammalian life: wakefulness, non-rapid eye movement (non-REM) sleep, and REM sleep. As more neural correlates of behavior are identified in freely moving animals, this three-fold subdivision becomes too simplistic. During wakefulness, ensembles of global and local cortical activities, together with peripheral parameters such as pupillary diameter and sympathovagal balance, define various degrees of arousal. It remains unclear the extent to which sleep also forms a continuum of brain states-within which the degree of resilience to sensory stimuli and arousability, and perhaps other sleep functions, vary gradually-and how peripheral physiological states co-vary...
August 2, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28809740/early-successes-in-an-open-access-provincially-funded-hepatitis-c-treatment-program-in-prince-edward-island
#8
Daniel Smyth, Jordan W Francheville, Robin Rankin, Jeremy Beck, Connie Hoare, Stefanie Materniak, Greg German, Lisa Barrett, Natalie Bunimov-Wall
INTRODUCTION: The availability of curative hepatitis C therapies has created an opportunity to improve delivery and access. Local providers, government, industry, and community groups in Prince Edward Island developed an innovative province-wide care model. Our goal was to describe the first year of program implementation. MATERIAL AND METHODS: Using a community based prospective observational study design, all chronic hepatitis C referrals received from April 2015 to April 2016 were recorded in a database...
August 8, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28809369/maxillofacial-fracture-epidemiology-and-treatment-plans-in-the-northeast-of-iran-a-retrospective-study
#9
S Samieirad, M-R Aboutorabzade, E Tohidi, B Shaban, H Khalife, M-A Hashemipour, H-R Salami
BACKGROUND: The epidemiology of facial injuries varies based on lifestyle, cultural background and socioeconomic status in different countries and geographic zones. This study evaluated the epidemiology of maxillofacial fractures and treatment plans in hospitalized patients in Northeast of Iran (2015-2016). MATERIAL AND METHODS: In this retrospective study, the medical records of 502 hospitalized patients were evaluated in the Department of Maxillofacial Surgery in Kamyab Hospital in Mashhad, Iran...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28808942/primary-care-providers-opening-of-time-sensitive-alerts-sent-to-commercial-electronic-health-record-inbaskets
#10
Sarah L Cutrona, Hassan Fouayzi, Laura Burns, Rajani S Sadasivam, Kathleen M Mazor, Jerry H Gurwitz, Lawrence Garber, Devi Sundaresan, Thomas K Houston, Terry S Field
BACKGROUND: Time-sensitive alerts are among the many types of clinical notifications delivered to physicians' secure InBaskets within commercial electronic health records (EHRs). A delayed alert review can impact patient safety and compromise care. OBJECTIVE: To characterize factors associated with opening of non-interruptive time-sensitive alerts delivered into primary care provider (PCP) InBaskets. DESIGN AND PARTICIPANTS: We analyzed data for 799 automated alerts...
August 14, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28808675/acute-appendicitis-in-pregnancy-and-the-developing-world
#11
Tika Ram Bhandari, Sudha Shahi, Sarita Acharya
BACKGROUND: Acute appendicitis is the commonest nonobstetric surgical emergency during pregnancy. The aim of the study was to compare perioperative outcomes of acute appendicitis in pregnant and nonpregnant patients. METHODS: A retrospective review of medical records of 56 pregnant patients between 2011 and 2016 who were compared with 164 nonpregnant women of reproductive age who underwent open appendectomy between 2014 and 2016 for acute appendicitis. The patient's demographics and perioperative data were analyzed...
2017: International Scholarly Research Notices
https://www.readbyqxmd.com/read/28808629/return-to-sport-following-tibial-plateau-fractures-a-systematic-review
#12
Greg A J Robertson, Seng J Wong, Alexander M Wood
AIM: To systemically review all studies reporting return to sport following tibial plateau fracture, in order to provide information on return rates and times to sport, and to assess variations in sporting outcome for different treatment methods. METHODS: A systematic search of CINAHAL, Cochrane, EMBASE, Google Scholar, MEDLINE, PEDro, Scopus, SPORTDiscus and Web of Science was performed in January 2017 using the keywords "tibial", "plateau", "fractures", "knee", "athletes", "sports", "non-operative", "conservative", "operative", "return to sport"...
July 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28808625/epidemiology-of-open-fractures-in-sport-one-centre-s-15-year-retrospective-study
#13
Alexander M Wood, Greg A J Robertson, Kirsty MacLeod, Anna Porter, Charles M Court-Brown
AIM: To describe the epidemiology of sport-related open fractures from one centre's adult patient population over a 15-year period. METHODS: A retrospective review of a prospectively-collected database was performed: The database contained information all sport-related open fractures, sustained from 1995 to 2009 in the Edinburgh, Mid and East Lothian Populations. RESULTS: Over the 15-year period, there were 85 fractures recorded in 84 patients...
July 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28805082/veterans-transitioning-from-isolation-to-integration-a-look-at-veteran-service-dog-partnerships
#14
Terry K Crowe, Victoria Sánchez, Alyse Howard, Brenna Western, Stephanie Barger
BACKGROUND: This study explored the dynamics of veteran/service dog partnerships by gathering the perspectives of veterans with a history of post-traumatic stress disorder and/or traumatic brain injury. METHODS: Exploratory qualitative methods (focus groups and individual interviews) were used to investigate veteran/service dog relationships related to community involvement, family and friend relationships, self-care, work, and leisure. Nine male veterans, Paws, and Stripes program graduates participated...
August 13, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28803796/shoulder-muscle-activation-patterns-and-levels-differ-between-open-and-closed-chain-abduction
#15
Darren Reed, Ian Cathers, Mark Halaki, Karen A Ginn
OBJECTIVES: Open and closed-chain abduction of the shoulder are commonly used in rehabilitation and exercise programs to assess and/or improve shoulder muscle function. However, it is not known if shoulder muscle activation patterns differ between these two exercises. Therefore the purpose of this study was to compare muscle activation patterns during closed-chain shoulder abduction performed using a shoulder press machine with open-chain abduction using free weights. DESIGN: Experimental study...
August 2, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28803773/low-dose-versus-high-dose-tranexamic-acid-reduces-the-risk-of-nonischemic-seizures-after-cardiac-surgery-with-cardiopulmonary-bypass
#16
Pierre Couture, Jean-Sébastien Lebon, Éric Laliberté, Georges Desjardins, Marie-Ève Chamberland, Christian Ayoub, Antoine Rochon, Jennifer Cogan, André Denault, Alain Deschamps
OBJECTIVE: The incidence of postoperative nonischemic seizures associated with the use of tranexamic acid (TXA) and the possibility of prevention with a low-dose regimen of TXA were evaluated. DESIGN: Retrospective study. SETTING: Tertiary care university hospital. PARTICIPANTS: A total of 12,195 patients who underwent cardiac surgical procedures under cardiopulmonary bypass (CPB) were evaluated. INTERVENTIONS: The files of every clinical seizure case diagnosed in the surgical intensive care unit between April 2006 and April 2014 were reviewed...
April 15, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28803585/performance-and-financial-consequences-of-stillbirth-in-holstein-dairy-cattle
#17
A Mahnani, A Sadeghi-Sefidmazgi, H Keshavarzi
Stillbirth is an economically important trait on dairy farms. Knowledge of the consequences of, and the economic losses associated with stillbirth can help the producer when making management decisions. The objectives of this study were to determine the effects of stillbirth on productive and reproductive performance as well as financial losses due to stillbirth incidence in Iranian Holstein dairy farms. Economic and performance data were collected from nine Holstein dairy farms in Isfahan and Khorasan provinces of Iran from March 2008 to December 2013...
August 14, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28803344/outcome-one-year-after-robot-assisted-rectal-cancer-surgery-a-consecutive-cohort-study
#18
Sanne Harsløf, Anders Stouge, Niels Thomassen, Sissel Ravn, Søren Laurberg, Lene Hjerrild Iversen
PURPOSE: The aim of this study was to investigate outcome after robot-assisted rectal cancer surgery (RARCS). We focused on conversion rate, postoperative complications, pathological evaluation (adequacy of resection margins), and bowel function (low anterior resection syndrome (LARS)) 1 year after surgery. METHODS: An observational study of prospectively registered patients with data obtained from medical records. Data comprise the initial 208 rectal cancer patients operated with robot-assisted surgery at a single Danish university hospital from October 2011 to October 2014...
August 13, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28802774/a-rule-based-dose-finding-design-for-use-in-stroke-rehabilitation-research-methodological-development
#19
E Colucci, A Clark, C E Lang, V M Pomeroy
BACKGROUND: Dose-optimisation studies as precursors to clinical trials are rare in stroke rehabilitation. OBJECTIVE: To develop a rule-based, dose-finding design for stroke rehabilitation research. DESIGN: 3+3 rule-based, dose-finding study. Dose escalation/de-escalation was undertaken according to preset rules and a mathematical sequence (modified Fibonacci sequence). The target starting daily dose was 50 repetitions for the first cohort...
January 20, 2017: Physiotherapy
https://www.readbyqxmd.com/read/28802620/modified-open-access-scheduling-for-new-patient-evaluations-at-an-academic-chronic-pain-clinic-increased-patient-access-to-care-but-did-not-materially-reduce-their-mean-cancellation-rate-a-retrospective-observational-study
#20
Eellan Sivanesan, David A Lubarsky, Chaturani T Ranasinghe, Constantine D Sarantopoulos, Richard H Epstein
STUDY OBJECTIVE: To determine if open-access scheduling would reduce the cancellation rate for new patient evaluations in a chronic pain clinic by at least 50%. DESIGN: Retrospective, observational study using electronic health records. SETTING: Chronic pain clinic of an academic anesthesia department. PATIENTS: All patients scheduled for evaluation or follow-up appointments in the chronic pain clinic between April 1, 2014, and December 31, 2015...
September 2017: Journal of Clinical Anesthesia
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