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https://www.readbyqxmd.com/read/28334974/efficacy-and-safety-of-sequential-use-of-everolimus-in-japanese-patients-with-advanced-renal-cell-carcinoma-after-failure-of-first-line-treatment-with-vascular-endothelial-growth-factor-receptor-tyrosine-kinase-inhibitor-a-multicenter-phase-ii-clinical-trial
#1
Masafumi Oyama, Takayuki Sugiyama, Masahiro Nozawa, Kiyohide Fujimoto, Takeshi Kishida, Go Kimura, Noriaki Tokuda, Shiro Hinotsu, Kojiro Shimozuma, Hideyuki Akaza, Seiichiro Ozono
Objective: Many studies have shown the efficacy of everolimus after pretreatment with vascular endothelial growth factor receptor-tyrosine kinase inhibitors. We investigated the efficacy and safety of everolimus as a second-line treatment after the failure of vascular endothelial growth factor receptor-tyrosine kinase inhibitor therapy in Japanese patients with advanced renal cell carcinoma. Methods: This was an open-label, multicenter, phase II trial conducted in Japan through the central registration system...
March 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28333892/the-effects-of-phacoemulsification-on-intraocular-pressure-and-topical-medication-use-in-patients-with-glaucoma-a-systematic-review-and-meta-analysis-of-3-year-data
#2
James J Armstrong, Tomas Wasiuta, Efstathia Kiatos, Monali Malvankar-Mehta, Cindy M L Hutnik
PURPOSE: For patients with comorbid cataract and primary open-angle glaucoma (POAG), guidance is lacking as to whether cataract extraction and traditional filtering surgery should be performed as a staged or combined procedure. Achieving this guidance requires an evidence-based understanding of the effects of phacoemulsification alone on intraocular pressure (IOP) in patients with POAG. For this reason, a systematic review and meta-analysis was undertaken to synthesize evidence quantifying the effect of phacoemulsification on IOP and the required number of topical glaucoma medications in patients with cataract and POAG...
March 22, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28333841/audit-of-ca125-follow-up-after-first-line-therapy-for-ovarian-cancer
#3
Daniel Krell, Fran Said Battistino, Sarah Benafif, Lochani Ganegoda, Marcia Hall, Gordon J S Rustin
AIMS: The Medical Research Council OVO5/EORTC 55955 trial showed that patients in remission after first-line therapy for ovarian cancer did not benefit from routine measurement of CA125 during follow-up. Since the presentation of these results, we have counseled patients about the options for follow-up and provided them with an information leaflet about the trial results and the symptoms that should prompt an early appointment and CA125 measurement. We present an audit of practice after the presentation of those results...
March 23, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28333526/learning-higher-order-generalizations-through-free-play-evidence-from-2-and-3-year-old-children
#4
Zi L Sim, Fei Xu
Constructivist views of cognitive development often converge on 2 key points: (a) the child's goal is to build large conceptual structures for understanding the world, and (b) the child plays an active role in developing these structures. While previous research has demonstrated that young children show a precocious capacity for concept and theory building when they are provided with helpful data within training settings, and that they explore their environment in ways that may promote learning, it remains an open question whether young children are able to build larger conceptual structures using self-generated evidence, a form of active learning...
April 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28332484/multivariate-regression-methods-for-estimating-velocity-of-ictal-discharges-from-human-microelectrode-recordings
#5
Jyun-You Liou, Elliot Smith, Lisa Bateman, Guy McKhann, Robert Goodman, Bradley Greger, Tyler Davis, Spencer Kellis, Paul House, Catherine Schevon
OBJECTIVE: Epileptiform discharges, an electrophysiological hallmark of seizures, can propagate across cortical tissue in a manner similar to traveling waves. Recent work has focused attention on the origination and propagation patterns of these discharges, yielding important clues to their source location and mechanism of travel. However, systematic studies of methods for measuring propagation are lacking. APPROACH: We analyzed epileptiform discharges in microelectrode array recordings of human seizures...
March 23, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28331446/lung-transplantation-and-the-routine-use-of-cardiopulmonary-bypass-and-median-sternotomy-experience-at-the-ochsner-multi-organ-transplant-institute
#6
Michael Bates, Matthew Factor, P Eugene Parrino, Aditya Bansal, Reinaldo Rampolla, Leonardo Seoane, Jose Mena, Matthew Gaudet, William Smith, P Michael McFadden
BACKGROUND: From 1990-2005 at Ochsner Medical Center in New Orleans, LA, cardiopulmonary bypass (CPB) was used only when necessary during lung transplantation surgeries. Ochsner's lung transplant program was closed for more than 4 years after Hurricane Katrina, and since the program's reestablishment in 2010, the majority of lung transplantation surgeries have been performed with the patient on CPB and with a median sternotomy incision. The purpose of this study was to compare the outcomes of the CPB and non-CPB groups...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28330826/the-influence-of-methamphetamine-on-maternal-behavior-and-development-of-the-pups-during-the-neonatal-period
#7
Mária Ševčíková, Ivana Hrebíčková, Eva Macúchová, Romana Šlamberová
Since it enters breast milk, methamphetamine (MA) abuse during lactation can not only affect the quality of maternal behavior but also postnatal development of pups. The aim of the present study was to examine the effect of injected MA (5mg/kg) on maternal behavior of rats and the differences in postnatal development, during postnatal days (PD) 1-11, of pups when the pups were directly exposed (i.e., injected) to MA or received MA indirectly via breast milk. Maternal behavior was examined using observation test (PD 1-22) and pup retrieval test (PD 1-12)...
March 18, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28330382/algorithm-based-motion-magnification-for-video-processing-in-urological-laparoscopy
#8
Fabian Adams, Reto Schoelly, Daniel Schlager, Martin Schoenthaler, Dominik Stefan Schoeb, Konrad Wilhelm, Simon Hein, Ulrich Wetterauer, Arkadiusz Miernik
PURPOSE: Minimally invasive surgery is in constant further development and has replaced many conventional operative procedures. If vascular structure movement could be detected during these procedures, it could reduce the risk of vascular injury and conversion to open surgery. The recently proposed motion-amplifying algorithm Eulerian Video Magnification (EVM) has been shown to substantially enhance minimal object changes in digitally recorded video that is barely perceptible to the human eye...
March 23, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28329603/job-recruitment
#9
University Of California Davis School Of Medicine
The University of California Davis, School of Medicine, Department of Dermatology is recruiting for a full-time position at the Associate or Full Professor level in the Clinical X Series or Health Sciences Clinical Professor (HSCP) Series. The successful candidate is nominated to be the holder of the Frederick G. Novy, Jr. M.D Endowed Professorship. Appointees to the ClinX series are expected to conduct independent research. Both series require significant participation in teaching and University/public service...
October 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329415/the-hand-hygiene-compliance-of-student-nurses-during-clinical-placements
#10
Jorun Saetre Sundal, Anne Grethe Aune, Eline Storvig, Jenny Kristin Aasland, Kaja Linn Fjeldsaeter, Kirsti Torjuul
AIMS AND OBJECTIVES: To observe student nurses' overall and moment-specific hand hygiene compliance during clinical placement. BACKGROUND: Hand hygiene is the single most important measure to prevent healthcare-associated infections (HAIs). However, research has shown low compliance among healthcare workers. During clinical placements, student nurses perform various nursing tasks and procedures to a large number of patients, requiring extensive patient contact. It is crucial that they practice correct hand hygiene in order to prevent healthcare-associated infections...
March 22, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28328742/treatment-of-proximal-humerus-fractures-in-children-with-a-modified-palm-tree-technique
#11
Ayman M Ali, Sallam I Fawzy, Medhat Moaty, Mohamed Abelaziz
Although most pediatric proximal humeral fractures can be successfully treated conservatively with satisfactory results, many operative techniques have been described for the treatment of displaced proximal humeral fractures. The aim of this study is to evaluate the efficacy of percutaneous fixation using a modified palm tree technique for proximal humerus fractures in children. Between March 2011 and May 2013, the modified palm tree technique was used for the management of 30 children (20 boys and 10 girls) with displaced proximal humeral fractures...
March 21, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28328598/simple-percutaneous-transbuccal-approach-for-management-of-mandibular-angular-fracture
#12
Mohammad Waheed El-Anwar, Ahmed Hassan Sweed
OBJECTIVE: To describe a relatively simple, easy, and safe technique for open reduction and internal fixation of the mandibular angle fracture using the combined modified percutaneous and oral approach with no special instrumentation. PATIENTS AND METHODS: This study was carried out on 10 patients who had traumatic mandibular angle fractures. All patients were managed by open reduction and internal fixation. Intraoral exposure and reduction of the fracture was performed through the gingivolabial incision...
March 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28328562/treatment-of-unstable-versus-stable-slipped-capital-femoral-epiphysis-using-the-modified-dunn-procedure
#13
Richard L Davis, Walter P Samora, Freddie Persinger, Kevin E Klingele
BACKGROUND: The modified Dunn procedure (open subcapital realignment via a surgical dislocation approach) has been shown to be a safe and effective way of treating acute, unstable slipped capital femoral epiphysis (SCFE). There is a paucity of literature comparing the modified Dunn procedure in stable SCFE. The purpose of this study was to compare acute, unstable versus chronic, stable SCFE managed with the modified Dunn procedure. METHODS: A retrospective chart review was performed on 44 skeletally immature patients who underwent the modified Dunn procedure for SCFE...
March 21, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28326704/-extramedullary-fixation-combined-with-intramedullary-fixation-in-the-surgical-reduction-of-sagittal-mandibular-condylar-fractures
#14
Chen Chuanjun, Chen Xiaoyang, Chen Jing
OBJECTIVE: This study aimed to evaluate the clinical effect of extramedullary fixation combined with intramedullary fixation during the surgical reduction of sagittal mandibular condylar fractures. METHODS: Twenty-four sagittal fractures of the mandibular condyle in18 patients were fixed by two appliances: intramedullary with one long-screw osteosynthesis or Kirschner wire and extramedullary with one micro-plate. The radiologically-recorded post-operative stability-associated com-plications included the screw/micro-plate loosening, micro-plate twisting, micro-plate fractures, and fragment rotation...
October 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28326443/radiological-clinical-and-functional-evaluation-using-the-quick-disabilities-of-the-arm-shoulder-and-hand-questionnaire-of-children-with-medial-epicondyle-fractures-treated-surgically
#15
Federico Canavese, Lorenza Marengo, Alexandru Tiris, Mounira Mansour, Marie Rousset, Antoine Samba, Antonio Andreacchio, Alain Dimeglio
PURPOSE: The main goal of this study was to retrospectively evaluate the clinical, functional and radiographic outcomes of displaced medial epicondyle fractures with or without associated elbow dislocation in children undergoing surgical treatment and to evaluate upper-extremity function with the Quick Disbilities of the Arm, Shoulder and Hand (Quick DASH) questionnaire. The hypothesis was that patients with associated elbow dislocation would have similar functional outcome to patients with displaced fractures with or without intra-articular entrapment of the medial epicondyle...
March 22, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28326320/duodenal-atresia-open-versus-mis-repair-analysis-of-our-experience-over-the-last-12-years
#16
Salvatore Fabio Chiarenza, Valeria Bucci, Maria Luisa Conighi, Elisa Zolpi, Lorenzo Costa, Lorella Fasoli, Cosimo Bleve
Objective. Duodenal atresia (DA) routinely has been corrected by laparotomy and duodenoduodenostomy with excellent long-term results. We revisited the patients with DA treated in the last 12 years (2004-2016) comparing the open and the minimally invasive surgical (MIS) approach. Methods. We divided our cohort of patients into two groups. Group 1 included 10 patients with CDO (2004-09) treated with open procedure: 5, DA; 3, duodenal web; 2, extrinsic obstruction. Three presented with Down's syndrome while 3 presented with concomitant malformations...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28326029/beta-oscillatory-changes-and-retention-of-motor-skills-during-practice-in-healthy-subjects-and-in-patients-with-parkinson-s-disease
#17
Aaron B Nelson, Clara Moisello, Jing Lin, Priya Panday, Serena Ricci, Andrea Canessa, Alessandro Di Rocco, Angelo Quartarone, Giuseppe Frazzitta, Ioannis U Isaias, Giulio Tononi, Chiara Cirelli, M Felice Ghilardi
Recently we found that modulation depth of beta power during movement increases with practice over sensory-motor areas in normal subjects but not in patients with Parkinson's disease (PD). As such changes might reflect use-dependent modifications, we concluded that reduction of beta enhancement in PD represents saturation of cortical plasticity. A few questions remained open: What is the relation between these EEG changes and retention of motor skills? Would a second task exposure restore beta modulation enhancement in PD? Do practice-induced increases of beta modulation occur within each block? We thus recorded EEG in patients with PD and age-matched controls in two consecutive days during a 40-min reaching task divided in fifteen blocks of 56 movements each...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28325448/diagnosis-of-autism-through-eeg-processed-by-advanced-computational-algorithms-a-pilot-study
#18
Enzo Grossi, Chiara Olivieri, Massimo Buscema
BACKGROUND: Multi-Scale Ranked Organizing Map coupled with Implicit Function as Squashing Time algorithm(MS-ROM/I-FAST) is a new, complex system based on Artificial Neural networks (ANNs) able to extract features of interest in computerized EEG through the analysis of few minutes of their EEG without any preliminary pre-processing. A proof of concept study previously published showed accuracy values ranging from 94%-98% in discerning subjects with Mild Cognitive Impairment and/or Alzheimer's Disease from healthy elderly people...
April 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28325009/a-clinic-compatible-open-source-electrophysiology-system
#19
John Hermiz, Nick Rogers, Erik Kaestner, Mehran Ganji, Dan Cleary, Joseph Snider, David Barba, Shadi Dayeh, Eric Halgren, Vikash Gilja
Open source electrophysiology (ephys) recording systems have several advantages over commercial systems such as customization and affordability enabling more researchers to conduct ephys experiments. Notable open source ephys systems include Open-Ephys, NeuroRighter and more recently Willow, all of which have high channel count (64+), scalability, and advanced software to develop on top of. However, little work has been done to build an open source ephys system that is clinic compatible, particularly in the operating room where acute human electrocorticography (ECoG) research is performed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324939/visual-transparent-visual-occlusion-an-eeg-and-cop-study
#20
Kwang Leng Goh, Susan Morris, Wee Lih Lee, Alexander Ring, Tele Tan
Electroencephalography (EEG) and centre of pressure (COP) data were recorded in young adults for 60 seconds during standing in visual transparent (VT) and visual occlusion (VO) conditions. In both of these conditions, participants wore VO liquid crystal spectacles which allowed the experimenter to accurately control visual information being presented or occluded to the participant. Alpha band (8-13 Hz) revealed significant differences in channel-averaged power spectrum in these two conditions, but not theta band (4-8 Hz) and beta band (13-30 Hz)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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