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Microcirculation

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https://www.readbyqxmd.com/read/28319406/effect-of-apelin-13-on-erythrocyte-deformability-during-ischaemia-reperfusion-injury-of-heart-in-diabetic-rats
#1
H Kartal, F M Comu, A Kucuk, Y Polat, A D Dursun, M Arslan
OBJECTIVES: Erythrocyte deformability and plasma viscosity are of crucial importance for the perfusion of tissues and organs. The aim of this study was to evaluate the effect of apelin-13 on erythrocyte deformability during IR heart injury in diabetic rats. METHODS: Eighteen Wistar Albino rats were included in the study after streptozotocin (55 mg/kg) treatment for four weeks of observation for diabetes existence. The animals were randomly assigned to one of five experimental groups...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28316167/-influences-of-high-voltage-electrical-burns-on-microcirculation-perfusion-on-serosal-surface-of-small-intestine-of-rats-and-the-interventional-effects-of-pentoxifylline
#2
Q F Zhang, S J Xu, L M Liang, J K Feng, Y F Xu, L L Tu
Objective: To investigate influences of high-voltage electrical burns on microcirculation perfusion on serosal surface of small intestine of rats and the interventional effects of pentoxifylline (PTX). Methods: Totally 180 SD rats were divided into sham injury group, simple electrical burn group, and treatment group according to the random number table, with 60 rats in each group. The electrical current was applied to the outside proximal part of left forelimb of rats and exited from the outside proximal part of right hind limb of rats...
March 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28306208/evaluation-of-myocardial-microcirculation-using-intravoxel-incoherent-motion-imaging
#3
Anna Mou, Chen Zhang, Mengying Li, Fengqiang Jin, Qingwei Song, Ailian Liu, Zhiyong Li
PURPOSE: To explore whether cardiac magnetic resonance-intravoxel incoherent motion imaging (MR-IVIM) is feasible for the clinical evaluation of myocardial microcirculation. MATERIALS AND METHODS: The study included 30 patients (with hypertrophic cardiomyopathy, diabetes mellitus, hypertension, or combined diabetes and hypertension) and 34 healthy volunteers. MR-IVIM with a maximum gradient strength of 50 mT/m was performed on the left ventricular short axis (apex, middle, and base), using multiple b values (0-500 s/mm(2) ) on a 3...
March 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28302706/acclimatization-of-the-systemic-microcirculation-to-alveolar-hypoxia-is-mediated-by-inos-dependent-increased-nitric-oxide-availability
#4
Alfred J Casillan, Jie Chao, John G Wood, Norberto C Gonzalez
Rats breathing 10% O2 show a rapid and widespread systemic microvascular inflammation that results from nitric oxide (NO) depletion secondary to increased reactive O2 species (ROS) generation. The inflammation eventually resolves and the microcirculation becomes resistant to more severe hypoxia. These experiments were directed to determine the mechanisms underlying this microvascular acclimatization process. Intravital microscopy of the mesentery showed that after three weeks of hypoxia (PB ~380 Torr, inspired PO2 ~ 68-70 Torr) rats showed no evidence of inflammation; however, treatment with the inducible NO synthase (iNOS) inhibitor L-N(6)-(1-Iminoethyl) lysine dihydrochloride (L-NIL) led to ROS generation, leukocyte-endothelial adherence and emigration, and increased vascular permeability...
March 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28302649/endothelial-protective-monocyte-patrolling-in-large-arteries-intensified-by-western-diet-and-atherosclerosis
#5
Amado Quintar, Sara McArdle, Dennis Wolf, Alex Marki, Erik Ehinger, Melanie Vassallo, Jacqueline F Miller, Zbigniew Mikulski, Klaus Ley, Konrad Buscher
Rationale: Non-classical mouse monocyte (CX3CR1(high), Ly-6C(low)) patrolling along the vessels of the microcirculation is critical for endothelial homeostasis and inflammation. Due to technical challenges it is currently not established how patrolling occurs in large arteries. Objective: This study was undertaken to elucidate the molecular, migratory and functional phenotype of patrolling monocytes in the high shear and pulsatile environment of large arteries in healthy, hyperlipidemic and atherosclerotic conditions...
March 16, 2017: Circulation Research
https://www.readbyqxmd.com/read/28301356/local-heating-test-for-detection-of-microcirculation-abnormalities-in-patients-with-diabetes-related-foot-complications
#6
Aleksey Parshakov, Nadezhda Zubareva, Sergey Podtaev, Peter Frick
OBJECTIVE: In this study, authors used a wavelet analysis of skin temperature (WAST) to assess the mechanisms of microvascular tone regulation during the local heating test in patients with diabetic foot syndrome (DFS). PARTICIPANTS: The participants included control subjects and 36 hospitalized patients with DFS between 52 and 79 years old (68 ± 8 years old). They were distributed among 5 groups: 15 control subjects, 8 patients with DFS who did not develop ulcerative or necrotic disorders, 10 patients who developed the neuroischemic form of DFS complicated by foot ulceration, 12 patients with DFS complicated by toe necrosis, and 6 patients with DFS and foot gangrene...
April 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28299952/n-acetylcysteine-s-role-in-sepsis-and-potential-benefit-in-patients-with-microcirculatory-derangements
#7
Jason Chertoff
OBJECTIVE: To review the data surrounding the utility of N-acetylcysteine (NAC) in sepsis and identify areas needed for additional research. DATA SOURCES: A review of articles describing the mechanisms of action and clinical use of NAC in sepsis. SUMMARY OF REVIEW: Despite many advances in critical care medicine, still as many as 50% of patients with septic shock die. Treatments thus far have focused on resuscitation and restoration of macrocirculatory targets in the early phases of sepsis, with less focus on microcirculatory dysfunction...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28298963/potential-role-of-imaging-in-assessing-harmful-effects-on-spermatogenesis-in-adult-testes-with-varicocele
#8
REVIEW
Athina C Tsili, Olga N Xiropotamou, Anastasios Sylakos, Vasilios Maliakas, Nikolaos Sofikitis, Maria I Argyropoulou
Varicocele is characterized by an abnormal dilatation and retrograde blood flow in the spermatic veins. Varicocele is the leading correctable cause of male infertility. Although it is highly prevalent in infertile men, it is also observed in individuals with normal fertility. Determining which men are negatively affected by varicocele would enable clinicians to better select those men who will benefit from treatment. To assess the functional status of the testes in men with varicocele, color Doppler sonographic parameters were evaluated...
February 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28298202/evaluation-of-sublingual-microcirculation-in-a-paediatric-intensive-care-unit-prospective-observational-study-about-its-feasibility-and-utility
#9
Rafael González, Jorge López, Javier Urbano, María José Solana, Sarah Nicole Fernández, María José Santiago, Jesús López-Herce
BACKGROUND: Evaluation of the microcirculation in critically ill patients is usually done by means of indirect parameters. The aim of our study was to evaluate the functional state of the microcirculation by direct visualization of sublingual microcirculation using Sidestream Dark Field Imaging, to determine the correlation between these findings and other parameters that are commonly used in the clinical practice and to assess the applicability of the systematic use of this technique in critically ill children...
March 15, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28295872/cellular-crosstalk-inflammatory-signals-and-enhanced-microvascular-permeability
#10
Jerome W Breslin
Microvascular leakage remains a significant clinical problem for which there is no specific therapeutic available. This Special Topics issue of the journal Microcirculation features reviews pertaining to the cellular and molecular mechanisms that control the integrity of the microvascular barrier. Meegan et al [1] summarize recent research findings about how neutrophil extracellular traps and how these can cause injury to the microvascular barrier. Zhang et al [2] highlight the microvascular response to advanced glycation end products that are formed as part of the pathophysiology of diabetes mellitus...
March 14, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28294194/phosphodiesterase-5-inhibition-preserves-renal-hemodynamics-and-function-in-mice-with-diabetic-kidney-disease-by-modulating-mir-22-and-bmp7
#11
Riccardo Pofi, Daniela Fiore, Rita De Gaetano, Giuseppe Panio, Daniele Gianfrilli, Carlotta Pozza, Federica Barbagallo, Yang Kevin Xiang, Konstantinos Giannakakis, Susanna Morano, Andrea Lenzi, Fabio Naro, Andrea M Isidori, Mary Anna Venneri
Diabetic Nephropathy (DN) is the leading cause of end-stage renal disease. Preclinical and experimental studies show that PDE5 inhibitors (PDE5is) exert protective effects in DN improving perivascular inflammation. Using a mouse model of diabetic kidney injury we investigated the protective proprieties of PDE5is on renal hemodynamics and the molecular mechanisms involved. PDE5i treatment prevented the development of DN-related hypertension (P < 0.001), the increase of urine albumin creatinine ratio (P < 0...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28290778/improved-neural-microcirculation-and-regeneration-after-peripheral-nerve-decompression-in-dpn-rats
#12
Wenxiang Zhong, Min Yang, Wenchuan Zhang, Massimiliano Visocchi, Xiangjun Chen, Chenlong Liao
OBJECTIVE: Recently, neural microcirculation and regeneration were regarded as critical factors in diabetic peripheral neuropathy (DPN) improvement. In the present study, we explored the cytological and molecular mechanisms how peripheral nerve decompression impaired nerve injury. METHODS: Forty-five male SD rats were established as the DPN model. HE staining was used to observe the morphology and distribution of microvessels. Transmission electron microscopy was applied to observe the morphology and distribution of Schwann cells...
March 14, 2017: Neurological Research
https://www.readbyqxmd.com/read/28289763/-gender-and-cardiovascular-diseases-why-we-need-gender-medicine
#13
V Regitz-Zagrosek
Gender medicine is concerned with the question of why diseases are expressed differently in the genders. It takes differences between men and women into account, which are often neglected by traditional medicine. Sex differences can also be found in cardiovascular diseases; therefore, risk factors for cardiovascular diseases have a different significance depending on the sex. Diabetic diseases tend to promote the occurrence of coronary heart disease (CHD) more strongly in women than in men. Myocardial infarctions affect women 10 years later than men and young women are often treated too late, possibly because myocardial infarction is consider to be a "male disease"...
March 13, 2017: Der Internist
https://www.readbyqxmd.com/read/28288978/mff-dependent-mitochondrial-fission-contributes-to-the-pathogenesis-of-cardiac-microvasculature-ischemia-reperfusion-injury-via-induction-of-mros-mediated-cardiolipin-oxidation-and-hk2-vdac1-disassociation-involved-mptp-opening
#14
Hao Zhou, Shunying Hu, Qinhua Jin, Chen Shi, Ying Zhang, Pingjun Zhu, Qiang Ma, Feng Tian, Yundai Chen
BACKGROUND: The cardiac microvascular system ischemia/reperfusion injury following percutaneous coronary intervention is a clinical thorny problem. This study explores the mechanisms by which ischemia/reperfusion injury induces cardiac microcirculation collapse. METHODS AND RESULTS: In wild-type mice, mitochondrial fission factor (Mff) expression increased in response to acute microvascular ischemia/reperfusion injury. Compared with wild-type mice, homozygous Mff-deficient (Mff(gt)) mice exhibited a smaller infarcted area, restored cardiac function, improved blood flow, and reduced microcirculation perfusion defects...
March 13, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28284829/histopathologic-changes-in-anti-angiotensin-ii-type-1-receptor-antibody-positive-kidney-transplant-recipients-with-acute-rejection-and-no-donor-specific-hla-antibodies
#15
Mary Ann Lim, Matthew Palmer, Jennifer Trofe-Clark, Roy Bloom, Annette Jackson, Mary Carmelle Philogene, Malek Kamoun
OBJECTIVE: To determine the association of antibodies against angiotensin II type 1 receptor (AT1R Ab) and histopathologic changes seen in patients with kidney allograft rejection and negative donor specific HLA antibodies (DSA). METHODS: Stored sera from 27 patients who had biopsy-proven rejection in the absence of DSA were tested for AT1R Ab. Biopsy slides of all patients were re-examined and classified according to Banff 2013 criteria. Histopathologic changes were compared between AT1R positive and negative patients...
March 8, 2017: Human Immunology
https://www.readbyqxmd.com/read/28282803/blood-storage-alters-mechanical-stress-responses-of-erythrocytes
#16
Elif Ugurel, Zeynep Kucuksumer, Buse Eglenen, Ozlem Yalcin
BACKGROUND: Erythrocytes undergo irreversible morphological and biochemical changes during storage. Reduced levels of deformability have been reported for stored erythrocytes. Erythrocyte deformability is essential for healthy microcirculation. OBJECTIVE: The aim of this study is to evaluate shear stress (SS) induced improvements of erythrocyte deformability in stored blood. METHODS: Deformability changes were evaluated by applying physiological levels of SS (5 and 10 Pa) in metabolically depleted blood for 48 hours and stored blood for 35 days with citrate phosphate dextrose adenine-1 (CPDA-1)...
March 4, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28282373/murine-models-of-scrub-typhus-associated-with-host-control-of-orientia-tsutsugamushi-infection
#17
Nicole L Mendell, Donald H Bouyer, David H Walker
BACKGROUND: Scrub typhus, a febrile illness of substantial incidence and mortality, is caused by infection with the obligately intracellular bacterium Orientia tsutsugamushi. It is estimated that there are more than one million cases annually transmitted by the parasitic larval stage of trombiculid mites in the Asia-Pacific region. The antigenic and genetic diversity of the multiple strains of O. tsutsugamushi hinders the advancement of laboratory diagnosis, development of long-lasting vaccine-induced protection, and interpretation of clinical infection...
March 10, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28281509/-pathogenetic-bases-and-efficacy-of-slow-calcium-channel-blockers-in-the-therapy-of-recurrent-peptic-ulcer-disease-associated-with-hypertension
#18
L A Fomina, V V Chernin
AIM: To clarify blood calcium concentrations (BCCs) as an indicator of the functional state of the calcium-regulating system in the concomitant course of recurrent peptic ulcer disease (PUD) and hypertension, by comparing with the severity of a ulcerous process, with changes in regional microcirculation, and with the functions of the stomach. To elucidate the pathogenetic justification for and clinical efficacy of slow calcium channel blockers (SCCBs) in the treatment of this comorbidity...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28281359/changes-in-skin-microcirculation-during-radiation-therapy-for-breast-cancer
#19
Erik Tesselaar, Anna M Flejmer, Simon Farnebo, Alexandru Dasu
BACKGROUND: The majority of breast cancer patients who receive radiation treatment are affected by acute radiation-induced skin changes. The assessment of these changes is usually done by subjective methods, which complicates the comparison between different treatments or patient groups. This study investigates the feasibility of new robust methods for monitoring skin microcirculation to objectively assess and quantify acute skin reactions during radiation treatment. MATERIAL AND METHODS: Laser Doppler flowmetry, laser speckle contrast imaging, and polarized light spectroscopy imaging were used to measure radiation-induced changes in microvascular perfusion and red blood cell concentration (RBC) in the skin of 15 patients undergoing adjuvant radiation therapy for breast cancer...
March 10, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28278077/anti-angiogenic-treatment-promotes-triple-negative-breast-cancer-invasion-via-vasculogenic-mimicry
#20
Huizhi Sun, Danfang Zhang, Zhi Yao, Xian Lin, Jiameng Liu, Qiang Gu, Xueyi Dong, Fang Liu, Yi Wang, Nan Yao, Siqi Cheng, Linqi Li, Shuya Sun
Agents that target angiogenesis have shown limited efficacy for human triple-negative breast cancer (TNBC) in clinical trials. Along with endothelium-dependent vessels, there is also vasculogenic mimicry (VM) in the microcirculation of malignant tumors. The role of VM is not completely understood regarding anti-angiogenic treatment. In this study, human TNBC MDA-MB-231 and Hs578T and non-TNBC MCF-7 and BT474 tumor-bearing mice were treated with sunitinib, an anti-angiogenic drug, using a clinically relevant schedule...
February 21, 2017: Cancer Biology & Therapy
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