Eniko Papp, Dorothy Hallberg, Gottfried E Konecny, Daniel C Bruhm, Vilmos Adleff, Michaël Noë, Ioannis Kagiampakis, Doreen Palsgrove, Dylan Conklin, Yasuto Kinose, James R White, Michael F Press, Ronny Drapkin, Hariharan Easwaran, Stephen B Baylin, Dennis Slamon, Victor E Velculescu, Robert B Scharpf
To improve our understanding of ovarian cancer, we performed genome-wide analyses of 45 ovarian cancer cell lines. Given the challenges of genomic analyses of tumors without matched normal samples, we developed approaches for detection of somatic sequence and structural changes and integrated these with epigenetic and expression alterations. Alterations not previously implicated in ovarian cancer included amplification or overexpression of ASXL1 and H3F3B, deletion or underexpression of CDC73 and TGF-beta receptor pathway members, and rearrangements of YAP1-MAML2 and IKZF2-ERBB4...
November 27, 2018: Cell Reports