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https://www.readbyqxmd.com/read/27754054/os-15-02-matrix-metalloproteinase-2-knockout-protects-from-angiotensin-ii-induced-vascular-injury-in-part-via-inhibition-of-egfr-and-erk1-2-activation
#1
Pierre Paradis, Tlili Barhoumi, Muhammad Oneeb Rehman Mian, Julio C Fraulob-Aquino, Asia Rehman, Nourredine Idris-Khodja, Ernesto L Schiffrin
OBJECTIVE: Matrix metalloproteinase 2 (MMP2) is involved in cardiovascular disease. Whether MMP2 plays a role in hypertension and vascular damage is unknown. We hypothesized that Mmp2 knockout will prevent angiotensin (Ang) II-induced hypertension and vascular injury. DESIGN AND METHOD: Mmp2 knockout (Mmp2) and wild-type (WT) mice were infused with Ang II (1000 ng/kg/min, SC) for 14 days. Systolic blood pressure (SBP) was measured by telemetry, and mesenteric artery (MA) endothelial function and vascular remodeling by pressurized myography...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753039/a-rapid-and-sensitive-method-for-detection-of-the-t790m-mutation-of-egfr-in-plasma-dna
#2
Hideharu Kimura, Shingo Nishikawa, Hayato Koba, Taro Yoneda, Takashi Sone, Kazuo Kasahara
Epidermal growth factor receptor (EGFR) T790M mutation is associated with resistance to EGFR tyrosine kinase inhibitors' (EGFR-TKIs) in non-small cell lung cancer (NSCLC). The aims of this study are to develop a blood-based, non-invasive approach to detecting the EGFR T790M mutation in advanced NSCLC patients, using PointMan™ EGFR DNA Enrichment Kit which is a novel method for selective amplification of genotype specific sequences.Pairs of blood samples and tumor tissues were collected from NSCLC patients with an EGFR activating mutation and who were resistant to EGFR-TKI treatment...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27726288/erlotinib-induces-the-human-non-small-cell-lung-cancer-cells-apoptosis-via-activating-ros-dependent-jnk-pathways
#3
Fenglian Shan, Zewei Shao, Shenghua Jiang, Zhaozhong Cheng
Although erlotinib (ERL) has drawn more and more attention toward its anticancer properties effect, the underlying mechanisms of ERL's anticancer properties effect remain unclear yet. So, the aim of this research was to explore the underlying anticancer mechanisms of ERL and to explore whether the reactive oxygen species (ROS)-dependent c-Jun N-terminal kinase (JNK) pathway contributed to the anticancer properties provided by ERL. In our study, we used MTT assay to detect the anticell growth ability of ERL on human non-small-cell lung cancer cell lines (A549)...
November 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27642974/os-15-02-matrix-metalloproteinase-2-knockout-protects-from-angiotensin-ii-induced-vascular-injury-in-part-via-inhibition-of-egfr-and-erk1-2-activation
#4
Pierre Paradis, Tlili Barhoumi, Muhammad Oneeb Rehman Mian, Julio C Fraulob-Aquino, Asia Rehman, Nourredine Idris-Khodja, Ernesto L Schiffrin
OBJECTIVE: Matrix metalloproteinase 2 (MMP2) is involved in cardiovascular disease. Whether MMP2 plays a role in hypertension and vascular damage is unknown. We hypothesized that Mmp2 knockout will prevent angiotensin (Ang) II-induced hypertension and vascular injury. DESIGN AND METHOD: Mmp2 knockout (Mmp2) and wild-type (WT) mice were infused with Ang II (1000 ng/kg/min, SC) for 14 days. Systolic blood pressure (SBP) was measured by telemetry, and mesenteric artery (MA) endothelial function and vascular remodeling by pressurized myography...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27633965/interaction-of-treatment-and-biomarker-in-advanced-nsclc
#5
Pingfu Fu, Afshin Dowlati, Nathan Pennell, Neelesh Sharma, Qizhi Yi, Balazs Halmos
PURPOSE: There has been a long-standing interest in the investigation of interactions in science. The objective of the study is to evaluate interaction between EGFR mutation and treatment from randomized, phase II study of chemotherapy versus chemotherapy plus erlotinib in patients with progressive NSCLC following clinical benefit from erlotinib. MATERIALS AND METHODS: Forty-six patients with advanced stage NSCLC and progression from erlotinib were randomized to receive chemotherapy (pemetrexed or docetaxel) or chemotherapy plus erlotinib between 2008 and 2012...
September 16, 2016: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/27519631/tamoxifen-has-a-proliferative-effect-in-endometrial-carcinoma-mediated-via-the-gper-egfr-erk-cyclin-d1-pathway-a-retrospective-study-and-an-in%C3%A2-vitro-study
#6
Lizhi Zhang, Yanmin Li, Lan Lan, Rong Liu, Yanhong Wu, Quanxin Qu, Ke Wen
Tamoxifen has been widely used to treat breast cancer as an endocrine therapy. However, tamoxifen is known to enhance the risk of developing endometrial cancer. We want to examine the effect of tamoxifen on endometrial cancer. In our retrospective study, we found that high grade, high stage, and lymph node metastasis were more common in tamoxifen users. In vitro 4-hydroxytamoxifen (OHT) induced cell proliferation and cell cycle promotion in type I and type II endometrial cancer cell lines, and this proliferation was blocked by GPER silencing...
December 5, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27358767/population-based-mri-atlases-of-spatial-distribution-are-specific-to-patient-and-tumor-characteristics-in-glioblastoma
#7
Michel Bilello, Hamed Akbari, Xiao Da, Jared M Pisapia, Suyash Mohan, Ronald L Wolf, Donald M O'Rourke, Maria Martinez-Lage, Christos Davatzikos
BACKGROUND AND PURPOSE: In treating glioblastoma (GB), surgical and chemotherapeutic treatment guidelines are, for the most part, independent of tumor location. In this work, we compiled imaging data from a large cohort of GB patients to create statistical atlases illustrating the disease spatial frequency as a function of patient demographics as well as tumor characteristics. MATERIALS AND METHODS: Two-hundred-six patients with pathology-proven glioblastoma were included...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27246726/icecream-randomised-phase-ii-study-of-cetuximab-alone-or-in-combination-with-irinotecan-in-patients-with-metastatic-colorectal-cancer-with-either-kras-nras-braf-and-pi3kca-wild-type-or-g13d-mutated-tumours
#8
Eva Segelov, Paul Waring, Jayesh Desai, Kate Wilson, Val Gebski, Subotheni Thavaneswaran, Elena Elez, Craig Underhill, Nick Pavlakis, Lorraine Chantrill, Louise Nott, Michael Jefford, Mustafa Khasraw, Fiona Day, Harpreet Wasan, Fortunato Ciardiello, Chris Karapetis, Warren Joubert, Guy van Hazel, Andrew Haydon, Tim Price, Sabine Tejpar, Niall Tebbutt, Jeremy Shapiro
BACKGROUND: Patients with metastatic colorectal cancer whose disease has progressed on oxaliplatin- and irinotecan-containing regimens may benefit from EGFR-inhibiting monoclonal antibodies if they do not contain mutations in the KRAS gene (are "wild type"). It is unknown whether these antibodies, such as cetuximab, are more efficacious in refractory metastatic colorectal cancer as monotherapy, or in combination with irinotecan. Lack of mutation in KRAS, BRAF and PIK3CA predicts response to EFGR-inhibitors...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27077749/enrichment-of-cells-with-cancer-stem-cell-like-markers-in-relapses-of-chemoresistant-patients-with-locally-advanced-head-and-neck-squamous-cell-carcinoma
#9
Juan J Grau, Ricard Mesía, Maria de la Iglesia-Vicente, Estrelania S Williams, Miren Taberna, Miguel Caballero, Ana-Belen Larque, Jorge de la Oliva, Carlos Cordón-Cardo, Josep Domingo-Domenech
BACKGROUND: Patients with head and neck squamous cell carcinoma (HNSCC) present different responses to chemotherapy and radiotherapy. One explanation may be the differences in the individual rates of stem cell-like cells. METHODS: We included patients with HNSCC and tumor progression or relapse. Tumor samples were obtained before and after primary chemotherapy, and immunohistochemical analyses were performed for CD44, HLA class I (HLA-I), pancytokeratin, and phosphorylated epidermal growth factor receptor (p-EGFR)...
2016: Oncology
https://www.readbyqxmd.com/read/27046001/choroidal-metastasis-as-a-presenting-manifestation-of-a-lung-adenocarcinoma-with-response-to-afatinib
#10
M Contreras-Díaz, A Medina-Tapia, G Martínez-Bernal, T Rueda-Rueda, F López-Herrero, F E Molina-Socola, J L Sánchez-Vicente
CASE REPORT: We present the case of a 55-year-old man with a non-small cell lung adenocarcinoma, who presented with choroidal metastasis. The patient showed a decrease in visual acuity. His evaluation revealed unilateral choroidal metastasis secondary to carcinoma of the lung. The patient received afatinib with complete regression of choroidal metastasis after one year follow-up. DISCUSSION: Choroidal metastasis may be the initial sign of lung cancer. This case highlights the importance of a thorough systemic evaluation in patients with choroidal tumours...
April 1, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/26985396/gene-mutation-discovery-research-of-non-smoking-lung-cancer-patients-due-to-indoor-radon-exposure
#11
REVIEW
Jung Ran Choi, Seong Yong Park, O Kyu Noh, Young Wha Koh, Dae Ryong Kang
Although the incidence and mortality for most cancers such as lung and colon are decreasing in several countries, they are increasing in several developed countries because of an unhealthy western lifestyles including smoking, physical inactivity and consumption of calorie-dense food. The incidences for lung and colon cancers in a few of these countries have already exceeded those in the United States and other western countries. Among them, lung cancer is the main cause of cancer death in worldwide. The cumulative survival rate at five years differs between 13 and 21 % in several countries...
2016: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/26967052/pi3k-akt-mtor-signaling-pathway-and-targeted-therapy-for-glioblastoma
#12
REVIEW
Xiaoman Li, Changjing Wu, Nianci Chen, Huadi Gu, Allen Yen, Liu Cao, Enhua Wang, Liang Wang
Glioblastoma multiform (GBM) is the most common malignant glioma of all the brain tumors and currently effective treatment options are still lacking. GBM is frequently accompanied with overexpression and/or mutation of epidermal growth factor receptor (EGFR), which subsequently leads to activation of many downstream signal pathways such as phosphatidylinositol 3-kinase (PI3K)/Akt/rapamycin-sensitive mTOR-complex (mTOR) pathway. Here we explored the reason why inhibition of the pathway may serve as a compelling therapeutic target for the disease, and provided an update data of EFGR and PI3K/Akt/mTOR inhibitors in clinical trials...
May 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/26797372/human-papillomavirus-and-epidermal-growth-factor-receptor-in-oral-cavity-and-oropharyngeal-squamous-cell-carcinoma-correlation-with-dynamic-contrast-enhanced-mri-parameters
#13
Yoon Seong Choi, Mina Park, Hyeong Ju Kwon, Yoon Woo Koh, Seung-Koo Lee, Jinna Kim
OBJECTIVE: The objective of this study was to investigate differences in dynamic contrast-enhanced MRI (DCE-MRI) parameters on the basis of the status of human papillomavirus (HPV) and epidermal growth factor receptor (EGFR) biomarkers in patients with squamous cell carcinoma (SCC) of the oral cavity and oropharynx by use of histogram analysis. MATERIALS AND METHODS: A total of 22 consecutive patients with oral cavity and oropharyngeal SCC underwent DCE-MRI before receiving treatment...
February 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/26780078/-efficacy-and-safety-of-antivascular-drugs-after-anti-efgr-aflibercept-after-cetuximab-a-clinical-case
#14
Francesca Aroldi, Alberto Zaniboni
We describe a case of a man affected by colon adenocarcinoma with metachronous nodes and liver metastases (resected), exposed to first line therapy with FOLFOX-cetuximab. After disease progression, a second line based on FOLFIRI-aflibercept was started achieving an initial partial response followed by a long-lasting disease stability with a good tolerability.
December 2015: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/26727637/clinical-pathologic-and-genetic-features-of-wilms-tumors-with-wtx-gene-mutation
#15
Sanda Alexandrescu, Sara Akhavanfard, Marian H Harris, Sara O Vargas
Clinical and pathologic features of patients with WTX-mutated Wilms tumor (WT) have not been studied in detail. We characterize the clinical and pathologic findings in WT with WTX abnormalities and provide comparison with WT without WTX mutation. Clinical, gross, and microscopic features in 35 patients with WT were examined. Karyotype was examined in a subset of cases. All cases had been previously analyzed for WTX, WT1, and CTNNB1 aberrations via array comparative genomic hybridization; OncoMap 4 high throughput genotyping was performed on 18 cases...
January 4, 2016: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/26691822/nonadiabatic-dynamics-may-be-probed-through-electronic-coherence-in-time-resolved-photoelectron-spectroscopy
#16
Kochise Bennett, Markus Kowalewski, Shaul Mukamel
We present a hierarchy of Fermi golden rules (FGRs) that incorporate strongly coupled electronic/nuclear dynamics in time-resolved photoelectron spectroscopy (TRPES) signals at different levels of theory. Expansion in the joint electronic and nuclear eigenbasis yields the numerically most challenging exact FGR (eFGR). The quasistatic Fermi Golden Rule (qsFGR) neglects nuclear motion during the photoionization process but takes into account electronic coherences as well as populations initially present in the pumped matter as well as those generated internally by coupling between electronic surfaces...
February 9, 2016: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/26648459/a-novel-curcumin-derivative-increases-the-cytotoxicity-of-raloxifene-in-estrogen-receptor-negative-breast-cancer-cell-lines
#17
Sebastien Taurin, Mhairi Nimick, Lesley Larsen, Rhonda J Rosengren
There is a need for new, safe and efficacious drug therapies for the treatment of estrogen receptor (ER)-negative breast cancers. Raloxifene and the 2nd generation curcumin derivative 2,6-bis(pyridin-4-ylmethylene)-cyclohexanone (RL91) have been shown to inhibit the growth of ER-negative breast cancer cells in vitro and in vivo. We investigated whether RL91 could enhance the growth-suppressive effects mediated by raloxifene in MDA-MB-231, MDA-MB-468, Hs578t and SkBr3 human breast cancer cell lines. The cytotoxicity was consistent across the cell lines but RL91 was more potent...
January 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/26543084/proteomics-as-a-guide-for-personalized-adjuvant-chemotherapy-in-patients-with-early-breast-cancer
#18
REVIEW
Franco Lumachi, Giordano B Chiara, Luisa Foltran, Stefano M M Basso
Proteomics allows for better understanding of the function and regulation of cancer cells mediated by intra- and extracellular signaling networks. Integrating such information with clinicopathological characteristics of the tumor may lead to either detection of disease biomarkers useful to differentiate high-from low-risk patients, or to identification of new drug targets. Adjuvant chemotherapy is currently a personalized treatment strategy, especially for breast cancer (BC) patients, and the risk assessment of each patient influences its use because the benefit strictly correlates with the level of risk...
November 2015: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/26514492/correlation-between-egfr-gene-mutations-and-lung-cancer-a-hospital-based-study
#19
Kavitha Matam, Iravathy Goud, Adi Maha Lakshmi M, V Ravi, K Sridhar, P Reddy Vijayanand, Srinivas Chakravarthy, S V S S Prasad, Shaik Nazia Tabassum, Noor Ahmad Shaik, Rabbani Syed, Khalid Khalaf Alharbi, Imran Ali Khan
Epidermal growth factor receptor (EGFR) is one of the targeted molecular markers in many cancers including lung malignancies. Gefitinib and erlotinib are two available therapeutics that act as specific inhibitors of tyrosine kinase (TK) domains. We performed a case-control study with formalin-fixed paraffin-embedded tissue blocks (FFPE) from tissue biopsies of 167 non-small cell lung carcinoma (NSCLC) patients and 167 healthy controls. The tissue biopsies were studied for mutations in exons 18-21 of the EGFR gene...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/26453408/long-term-effect-of-lithium-maintenance-therapy-on-estimated-glomerular-filtration-rate-in-patients-with-affective-disorders-a-population-based-cohort-study
#20
Stefan Clos, Petra Rauchhaus, Alison Severn, Lynda Cochrane, Peter T Donnan
BACKGROUND: For more than 40 years, the long-term effect of lithium maintenance therapy on renal function has been debated. We aimed to assess the effect of lithium maintenance therapy on estimated glomerular filtration rate (eFGR) in patients with affective disorders, and explore predictors for a decrease in eGFR. METHODS: This population-based cohort study included adult patients (18-65 years of age at baseline) in Tayside (Scotland, UK) who had recently started on lithium maintenance treatment between Jan 1, 2000, and Dec 31, 2011 (retrospectively assigned to the lithium group) or those with exposure to other first-line drugs used in the treatment of affective disorders (quetiapine, olanzapine, and semisodium valproate) during the same period (retrospectively assigned to the comparator group)...
December 2015: Lancet Psychiatry
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