keyword
https://read.qxmd.com/read/38402586/escrt-i-protein-ubap1-controls-ventricular-expansion-and-cortical-neurogenesis-via-modulating-adherens-junctions-of-radial-glial-cells
#21
JOURNAL ARTICLE
Danping Lu, Yiqiang Zhi, Huizhen Su, Xiang Lin, Jingjing Lin, Yan Shi, Wenxiang Yi, Chaoyin Hong, Tongtong Zhang, Zhifei Fu, Li-Yu Chen, Zhiqi Zhao, Rong Li, Zhiheng Xu, Wanjin Chen, Ning Wang, Dan Xu
Intricate cerebral cortex formation is orchestrated by the precise behavior and division dynamics of radial glial cells (RGCs). Endocytosis functions in the recycling and remodeling of adherens junctions (AJs) in response to changes in RGC activity and function. Here, we show that conditional disruption of ubiquitin-associated protein 1 (UBAP1), a component of endosomal sorting complex required for transport (ESCRT), causes severe brain dysplasia and prenatal ventriculomegaly. UBAP1 depletion disrupts the AJs and polarity of RGCs, leading to failure of apically directed interkinetic nuclear migration...
February 24, 2024: Cell Reports
https://read.qxmd.com/read/38387734/sex-specific-differences-in-resting-oscillatory-dynamics-in-children-with-prenatal-alcohol-exposure
#22
JOURNAL ARTICLE
Felicha T Candelaria-Cook, Megan E Schendel, Lucinda Flynn, Cassandra Cerros, Dina E Hill, Julia M Stephen
At rest children with prenatal alcohol exposure (PAE) exhibit impaired static and dynamic functional connectivity, along with decreased alpha oscillations. Sex-specific information regarding the impact of PAE on whole-brain resting-state gamma spectral power remains unknown. Eyes-closed and eyes-open MEG resting-state data were examined in 83 children, ages 6 to 13 years of age. Using a matched design, the sample consisted of 42 typically developing children (TDC) (22 males/20 females) and 41 children with PAE and/or a fetal alcohol spectrum disorders (FASD) diagnosis (21 males/20 females)...
February 20, 2024: Neuroscience
https://read.qxmd.com/read/38383496/smarca4-loss-and-mutated-%C3%AE-catenin-induce-proliferative-lesions-in-the-murine-embryonic-cerebellum
#23
JOURNAL ARTICLE
Carolin Göbel, Melanie Schoof, Dörthe Holdhof, Michael Spohn, Ulrich Schüller
Almost all medulloblastomas (MB) of the Wingless/Int-1 (WNT) type are characterized by hotspot mutations in CTNNB1, and mouse models have convincingly demonstrated the tumor-initiating role of these mutations. Additional alterations in SMARCA4 are detected in around 20% of WNT MB, but their functional role is mostly unknown. We therefore amended previously described Blbp-cre::Ctnnb1(ex3)fl/wt mice by the introduction of floxed Smarca4 alleles. Unexpectedly, mutated and thereby stabilized β-catenin on its own induced severe developmental phenotypes in male and female Blbp-cre::Ctnnb1(ex3)fl/wt mice in our hands, including a thinned cerebral cortex, hydrocephalus, missing cerebellar layering, and cell accumulations in the brain stem and cerebellum...
February 21, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38378927/right-frontal-cingulate-cortex-mediates-the-effect-of-prenatal-complications-on-youth-internalizing-behaviors
#24
JOURNAL ARTICLE
Eleonora Maggioni, Alessandro Pigoni, Elisa Fontana, Giuseppe Delvecchio, Carolina Bonivento, Valentina Bianchi, Maddalena Mauri, Monica Bellina, Rossano Girometti, Nivedita Agarwal, Maria Nobile, Paolo Brambilla
Prenatal and perinatal complications represent well-known risk factors for the future development of psychiatric disorders. Such influence might become manifested during childhood and adolescence, as key periods for brain and behavioral changes. Internalizing and externalizing behaviors in adolescence have been associated with the risk of psychiatric onset later in life. Both brain morphology and behavior seem to be affected by obstetric complications, but a clear link among these three aspects is missing. Here, we aimed at analyzing the association between prenatal and perinatal complications, behavioral issues, and brain volumes in a group of children and adolescents...
February 20, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38356650/the-domestic-chick-as-an-animal-model-of-autism-spectrum-disorder-building-adaptive-social-perceptions-through-prenatally-formed-predispositions
#25
REVIEW
Toshiya Matsushima, Takeshi Izumi, Giorgio Vallortigara
Equipped with an early social predisposition immediately post-birth, humans typically form associations with mothers and other family members through exposure learning, canalized by a prenatally formed predisposition of visual preference to biological motion, face configuration, and other cues of animacy. If impaired, reduced preferences can lead to social interaction impairments such as autism spectrum disorder (ASD) via misguided canalization. Despite being taxonomically distant, domestic chicks could also follow a homologous developmental trajectory toward adaptive socialization through imprinting, which is guided via predisposed preferences similar to those of humans, thereby suggesting that chicks are a valid animal model of ASD...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38342906/effect-of-parental-adverse-childhood-experiences-on-intergenerational-dna-methylation-signatures-from-peripheral-blood-mononuclear-cells-and-buccal-mucosa
#26
JOURNAL ARTICLE
Sahra Mohazzab-Hosseinian, Erika Garcia, Joseph Wiemels, Crystal Marconett, Karina Corona, Caitlin G Howe, Helen Foley, Shohreh F Farzan, Theresa M Bastain, Carrie V Breton
In this study, the effect of cumulative ACEs experienced on human maternal DNA methylation (DNAm) was estimated while accounting for interaction with domains of ACEs in prenatal peripheral blood mononuclear cell samples from the Maternal and Developmental Risks from Environmental Stressors (MADRES) pregnancy cohort. The intergenerational transmission of ACE-associated DNAm was also explored used paired maternal (N = 120) and neonatal cord blood (N = 69) samples. Replication in buccal samples was explored in the Children's Health Study (CHS) among adult parental (N = 31) and pediatric (N = 114) samples...
February 12, 2024: Translational Psychiatry
https://read.qxmd.com/read/38342472/perinatal-depression-and-infant-and-toddler-neurodevelopment-a-systematic-review-and-meta-analysis
#27
REVIEW
Xiaoxiao Fan, Ni Wu, Yiming Tu, Tianzi Zang, Jinbing Bai, Ganggang Peng, Yanqun Liu
Many studies have focused on the effect of perinatal depression on neurodevelopment among children and adolescents. However, only a few studies have explored this relationship in infants and toddlers with inconsistent results. We performed a systematic review and meta-analysis to evaluate the association between perinatal depression and infant and toddler neurodevelopment during the first two postnatal years. Twenty-three studies were included in this meta-analysis. Perinatal depression was associated with poorer cognitive (Cohen's d = -0...
February 10, 2024: Neuroscience and Biobehavioral Reviews
https://read.qxmd.com/read/38309498/developmental-alcohol-exposure-is-exhausting-sleep-and-the-enduring-consequences-of-alcohol-exposure-during-development
#28
REVIEW
Donald A Wilson, Regina M Sullivan, John F Smiley, Mariko Saito, Charlis Raineki
Prenatal alcohol exposure is the leading nongenetic cause of human intellectual impairment. The long-term impacts of prenatal alcohol exposure on health and well-being are diverse, including neuropathology leading to behavioral, cognitive, and emotional impairments. Additionally negative effects also occur on the physiological level, such as the endocrine, cardiovascular, and immune systems. Among these diverse impacts is sleep disruption. In this review, we describe how prenatal alcohol exposure affects sleep, and potential mechanisms of those effects...
February 1, 2024: Neuroscience and Biobehavioral Reviews
https://read.qxmd.com/read/38307841/prenatal-exposure-to-maternal-disadvantage-related-inflammatory-biomarkers-associations-with-neonatal-white-matter-microstructure
#29
JOURNAL ARTICLE
Ashley F P Sanders, Brian Tirado, Nicole A Seider, Regina L Triplett, Rachel E Lean, Jeffrey J Neil, J Philip Miller, Rebecca Tillman, Tara A Smyser, Deanna M Barch, Joan L Luby, Cynthia E Rogers, Christopher D Smyser, Barbara B Warner, Edith Chen, Gregory E Miller
Prenatal exposure to heightened maternal inflammation has been associated with adverse neurodevelopmental outcomes, including atypical brain maturation and psychiatric illness. In mothers experiencing socioeconomic disadvantage, immune activation can be a product of the chronic stress inherent to such environmental hardship. While growing preclinical and clinical evidence has shown links between altered neonatal brain development and increased inflammatory states in utero, the potential mechanism by which socioeconomic disadvantage differentially impacts neural-immune crosstalk remains unclear...
February 2, 2024: Translational Psychiatry
https://read.qxmd.com/read/38304999/agmatine-ameliorates-valproic-acid-induced-depletion-of-parvalbumin-positive-neuron
#30
JOURNAL ARTICLE
Khadijeh Mirzaee Khoram-Abadi, Mohsen Basiri, Mozhdeh Nemati, Masoumeh Nozari
Autism spectrum disorder (ASD) is a widespread neurodevelopmental disorder with unknown etiology. Dysfunction of several brain areas including the prefrontal cortex (PFC), hippocampus, and cerebellum is involved in cognitive and behavioral deficits associated with ASD. Several studies have reported a reduction in the number of parvalbumin-immunoreactive (PV+ ) neurons in brain areas of ASD patients and animal models such as a shank mutant mouse model and rodents receiving fetal valproic acid (VPA) administration...
February 2, 2024: International Journal of Developmental Neuroscience
https://read.qxmd.com/read/38274439/the-protective-role-of-prenatal-administration-of-ascorbic-acid-on-autistic-like-behavior-in-a-rat-model-of-autism
#31
JOURNAL ARTICLE
Parisa Margedari, Iran Goudarzi, Hamid Sepehri
BACKGROUND: Autism is a complicated neurodevelopmental disorder characterized by several behavioral impairments. The pathology of autism is complex and not fully known. Several recent studies have shown alterations in the activities of antioxidant enzymes in autism. Vitamin C is a potent antioxidant that is present in high concentrations in the brain and acts as a neuromodulator. Prefrontal abnormality has been hypothesized to underlie autistic symptoms. The present study investigated the protective effect of prenatally Vitamin C on autistic-like behaviors, oxidative stress status, and histopathological change of prefrontal in valproic acid (VPA) rat model of autism...
June 2024: IBRO neuroscience reports
https://read.qxmd.com/read/38212375/placental-transcriptomic-signatures-of-prenatal-and-preconceptional-maternal-stress
#32
JOURNAL ARTICLE
Brennan H Baker, Sophie Freije, James W MacDonald, Theo K Bammler, Ciara Benson, Kecia N Carroll, Daniel A Enquobahrie, Catherine J Karr, Kaja Z LeWinn, Qi Zhao, Nicole R Bush, Sheela Sathyanarayana, Alison G Paquette
Prenatal exposure to maternal psychological stress is associated with increased risk for adverse birth and child health outcomes. Accumulating evidence suggests that preconceptional maternal stress may also be transmitted intergenerationally to negatively impact offspring. However, understanding of mechanisms linking these exposures to offspring outcomes, particularly those related to placenta, is limited. Using RNA sequencing, we identified placental transcriptomic signatures associated with maternal prenatal stressful life events (SLEs) and childhood traumatic events (CTEs) in 1 029 mother-child pairs in two birth cohorts from Washington state and Memphis, Tennessee...
January 11, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38178780/feeding-metformin-during-pregnancy-and-lactation-periods-improved-learning-and-memory-impairment-in-the-rat-offspring-exposed-to-febrile-seizure-role-of-oxidative-stress-and-inflammatory-response
#33
JOURNAL ARTICLE
Niloofar Khoshroo, Ali Rahimi, Samaneh Kakhki, Fatemeh Kaffashan, Maha Masoudi, Soheil Baharlou, Farimah Beheshti
BACKGROUND: Many clinical evidences have reported the higher risk of seizure in young children and infants after exposure to hyperthermia, which more likely can cause brain damage and affect cognitive function, so, many researches were focused on prevention or treatment of febrile seizure (FS) with minimal adverse effects. Considering the potential effects of oxidative stress as a prominent trigger in FS, and demonstrating the anti-oxidant effects of metformin, the present study aimed to investigate the protective effect of metformin administration in prenatal and lactation periods in rat pups exposed to hyperthermia by which induced seizure...
January 5, 2024: International Journal of Developmental Neuroscience
https://read.qxmd.com/read/38147261/divergent-pattern-of-development-in-rats-and-humans
#34
JOURNAL ARTICLE
Wanda Campos Eusebi, Tomas Iorii, Antonella Presti, Rafael Grimson, Pablo Vázquez-Borsetti
Rattus norvegicus is the second most used laboratory species and the most widely used model in neuroscience. Nonetheless, there is still no agreement regarding the temporal relationship of development between humans and rats. We addressed this question by examining the time required to reach a set of homologous developmental milestones in both species. With this purpose, a database was generated with data collected through a bibliographic survey. This database was in turn compared with other databases about the same topic present in the literature...
December 26, 2023: Neurotoxicity Research
https://read.qxmd.com/read/38130695/evaluating-different-models-of-maternal-stress-on-stress-responsive-systems-in-prepubertal-mice
#35
JOURNAL ARTICLE
Julietta A Sheng, Robert J Handa, Stuart A Tobet
INTRODUCTION: Maternal adversity during pregnancy influences neurodevelopment in human and model animal offspring. Adversity can result from stressors coming from many different directions ranging from environmental to nutritional and physiological to immune (e.g., infection). Most stressors result in fetal overexposure to glucocorticoids that have been directly linked to long- and short-term negative impacts on neurological health of offspring. Neuropsychiatric diseases postulated to have fetal origins are diverse and include such things cardiovascular disease, obesity, affective disorders, and metabolic and immune disorders...
2023: Frontiers in Neuroscience
https://read.qxmd.com/read/38110192/maternal-separation-stress-through-triggering-of-the-neuro-immune-response-in-the-hippocampus-induces-autistic-like-behaviors-in-male-mice
#36
JOURNAL ARTICLE
Vahid Reisi-Vanani, Zahra Lorigooini, Elham Bijad, Hossein Amini-Khoei
Autism spectrum disorder (ASD) is the fastest-growing neurodevelopmental disease throughout the world. Neuro-immune responses from prenatal to adulthood stages of life induce developmental defects in synaptic signaling, neurotransmitter imbalance, and even structural changes in the brain. In this study, we aimed to focus on the possible role of neuroinflammatory response in the hippocampus in development of the autistic-like behaviors following maternal separation (MS) stress in mice. To do this, mice neonates daily separated from their mothers from postnatal day (PND) 2 to PND 14 for 3 h...
December 18, 2023: International Journal of Developmental Neuroscience
https://read.qxmd.com/read/38105264/bdnf-nrf-2-crosstalk-and-emotional-behavior-are-disrupted-in-a-sex-dependent-fashion-in-adolescent-mice-exposed-to-maternal-stress-or-maternal-obesity
#37
JOURNAL ARTICLE
Chiara Musillo, Kerstin C Creutzberg, Barbara Collacchi, Maria Antonietta Ajmone-Cat, Roberta De Simone, Marcello Lepre, Irmgard Amrein, Marco A Riva, Alessandra Berry, Francesca Cirulli
Maternal obesity has been recognized as a stressor affecting the developing fetal brain, leading to long-term negative outcomes comparable to those resulting from maternal psychological stress, although the mechanisms have not been completely elucidated. In this study, we tested the hypothesis that adverse prenatal conditions as diverse as maternal stress and maternal obesity might affect emotional regulation and stress response in the offspring through common pathways, with a main focus on oxidative stress and neuroplasticity...
December 18, 2023: Translational Psychiatry
https://read.qxmd.com/read/38074523/early-emotional-caregiving-environment-and-associations-with-memory-performance-and-hippocampal-volume-in-adolescents-with-prenatal-drug-exposure
#38
JOURNAL ARTICLE
Brooke H Kohn, Zehua Cui, Margo A Candelaria, Stacy Buckingham-Howes, Maureen M Black, Tracy Riggins
Early adversities, including prenatal drug exposure (PDE) and a negative postnatal emotional caregiving environment, impact children's long-term development. The protracted developmental course of memory and its underlying neural systems offer a valuable framework for understanding the longitudinal associations of pre- and postnatal factors on children with PDE. This study longitudinally examines memory and hippocampal development in 69 parent-child dyads to investigate how the early caregiving emotional environment affects children with PDE's neural and cognitive systems...
2023: Frontiers in Behavioral Neuroscience
https://read.qxmd.com/read/38062042/epigenome-wide-association-studies-of-prenatal-maternal-mental-health-and-infant-epigenetic-profiles-a-systematic-review
#39
Emily Drzymalla, Krista S Crider, Arick Wang, Gwinn Marta, Muin J Khoury, Danielle Rasooly
Prenatal stress and poor maternal mental health are associated with adverse offspring outcomes; however, the biological mechanisms are unknown. Epigenetic modification has linked maternal health with offspring development. Epigenome-wide association studies (EWAS) have examined offspring DNA methylation profiles for association with prenatal maternal mental health to elucidate mechanisms of these complex relationships. The objective of this study is to provide a comprehensive, systematic review of EWASs of infant epigenetic profiles and prenatal maternal anxiety, depression, or depression treatment...
December 7, 2023: Translational Psychiatry
https://read.qxmd.com/read/38027471/spectral-based-thickness-profiling-of-the-corpus-callosum-enhances-anomaly-detection-in-fetal-alcohol-spectrum-disorders
#40
JOURNAL ARTICLE
Justine Fraize, Yann Leprince, Monique Elmaleh-Bergès, Eliot Kerdreux, Richard Delorme, Lucie Hertz-Pannier, Julien Lefèvre, David Germanaud
INTRODUCTION: Fetal alcohol spectrum disorders (FASD) range from fetal alcohol syndrome (FAS) to non-syndromic forms (NS-FASD). The neuroanatomical consequences of prenatal alcohol exposure are mainly the reduction in brain size, but also focal abnormalities such as those of the corpus callosum (CC). We previously showed a narrowing of the CC for brain size, using manual measurement and its usefulness to improve diagnostic certainty. Our aim was to automate these measurements of the CC and identify more recurrent abnormalities in FAS subjects, independently of brain size reduction...
2023: Frontiers in Neuroscience
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