Hetal P Patel, Priya H Desai, Rikin V Patel, Sandesh N Lodha, Anil H Gore, Pravin O Patil, Bhargavi V Desai, Ditixa T Desai, Bhavin A Vyas, Mark D P Willcox, Furqan A Maulvi
Clozapine, which is widely used to treat schizophrenia, shows low bioavailability due to poor solubility and high first-pass metabolism. The study aimed to design clozapine-loaded carbon dots (CDs) to enhance availability of the clozapine to the brain via intranasal pathway. The CDs were synthesized by pyrolysis of citric acid and urea at 200 °C by hydrothermal technique and characterized by photoluminescence, transmission electron microscopy (TEM), X-ray Photoelectron Spectrometer (XPS), and Fourier transform infrared spectrum (FTIR)...
March 20, 2024: Colloids and Surfaces. B, Biointerfaces