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Active release technique

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https://www.readbyqxmd.com/read/28936500/confined-naalh4-nanoparticles-inside-ceo2-hollow-nanotubes-towards-enhanced-hydrogen-storage
#1
Qili Gao, Guanglin Xia, Xuebin Yu
NaAlH4 has been widely regarded as a potential hydrogen storage material due to its favorable thermodynamics and high energy density. The high activation energy barrier and high dehydrogenation temperature, however, significantly hinder its practical application. In this paper, CeO2 hollow nanotubes (HNTs) prepared by a simple electrospinning technique are adopted as functional scaffolds to support NaAlH4 nanoparticles (NPs) towards advanced hydrogen storage performance. The nanoconfined NaAlH4 inside CeO2 HNTs, synthesized via the infiltration of molten NaAlH4 into the CeO2 HNTs under high hydrogen pressure, exhibited significantly improved dehydrogenation properties compared with both bulk and ball-milled CeO2 HNTs-catalyzed NaAlH4...
September 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/28931488/carboxylate-cross-linked-cyclodextrin-a-nanoporous-scaffold-for-enhancement-of-rosuvastatin-oral-bioavailability
#2
Mai Mahmoud Gabr, Sana Mohamed Mortada, Marwa Ahmed Sallam
Cyclodextrins play an important role in supramolecular chemistry acting as building blocks than can be cross-linked by various linker molecules forming nano-porous structures called nanosponges (NS). NS have the ability to enhance the stability, solubility and bioavailability of various actives. This work aimed at elaborating rosuvastatin (ROS) loaded NS to improve its oral bioavailability. Carboxylate-linked NS were synthesized by reacting β-CD with pyromellitic dianhydride (PDA) at different molar ratios under specific conditions...
September 17, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28929267/increasing-distribution-of-drugs-released-from-in-situ-forming-plga-implants-using-therapeutic-ultrasound
#3
Chawan Manaspon, Christopher Hernandez, Pinunta Nittayacharn, Selva Jeganathan, Norased Nasongkla, Agata A Exner
One of the challenges in developing sustained-release local drug delivery systems is the limited treatment volume that can be achieved. In this work, we examine the effectiveness of using low frequency, high intensity ultrasound to promote the spatial penetration of drug molecules away from the implant/injection site boundary upon release from injectable, phase inverting poly(lactic acid-co-glycolic acid) (PLGA) implants. Fluorescein-loaded PLGA solutions were injected into poly(acrylamide) phantoms, and the constructs were treated daily for 14 days with ultrasound at 2...
September 19, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28924348/single-walled-carbon-nanotubes-ciprofloxacin-nanoantibiotic-strategy-to-improve-ciprofloxacin-antibacterial-activity
#4
Mohyeddin Assali, Abdel Naser Zaid, Farah Abdallah, Motasem Almasri, Rasha Khayyat
As infectious diseases continue to be one of the greatest health challenges worldwide, the demand toward alternative agents is continuously increasing. Recent advancement in nanotechnology has expanded our ability to design and construct nanomaterials to treat bacterial infections. Carbon nanotubes are one among these nanomaterials. Herein, we describe the covalent functionalization of the single-walled carbon nanotubes (SWCNTs) with multiple molecules of ciprofloxacin. The prepared nanoantibiotics were characterized using different techniques, including transmission electron microscopy, Raman spectroscopy, and thermogravimetric analysis...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28923769/reconstitutable-spray-dried-ultra-fine-dispersion-as-a-robust-platform-for-effective-oral-delivery-of-an-antihyperlipidemic-drug
#5
Mona Basha, Alaa H Salama, Sally El Awdan
The current article highlights the application of spray drying technique to produce an ultra-fine powder encapsulating the antihyperlipidemic drug, atorvastatin calcium (ATV). First, ATV was dissolved in an emulsion formulation, and different carriers (pectin, alginate, chitosan HCl and hydroxypropylmethyl cellulose) in two concentrations (1.5 and 3%) were added. Then, these carrier-containing formulations were subjected to spray drying, whereby ultra-fine ATV-loaded spray dried emulsions were produced (ATV-SDE)...
September 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28921596/single-cocaine-exposure-does-not-alter-striatal-presynaptic-dopamine-function-in-mice-an-18-f-fdopa-pet-study
#6
D R Bonsall, M Kokkinou, M Veronese, C Coello, L A Wells, O D Howes
Cocaine is a recreational drug of abuse that binds to the dopamine transporter (DAT), preventing reuptake of dopamine into presynaptic terminals. The increased presence of synaptic dopamine results in stimulation of both pre- and postsynaptic dopamine receptors, considered an important mechanism by which cocaine elicits its reinforcing properties. However, the effects of acute cocaine administration on presynaptic dopamine function remain unclear. Non-invasive imaging techniques such as positron emission tomography (PET) have revealed impaired presynaptic dopamine function in chronic cocaine users...
September 18, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28918449/immunochemical-study-of-the-effect-of-f2glc-on-glycogen-synthase-translocation-and-glycogen-synthesis-in-isolated-rat-hepatocytes
#7
J M Fernández-Novell, M Díaz-Lobo
The compound 2-deoxy-2-fluoro-α-D-glucopyranosyl fluoride (F2Glc), which is a nonmetabolized superior glucose analogue, is a potent inhibitor of glycogen phosphorylase and pharmacological properties are reported. Glycogen phosphorylase (GP) and glycogen synthase (GS) are responsible of the degradation and synthesis, respectively, of glycogen which is a polymer of glucose units that provides a readily available source of energy in mammals. GP and GS are two key enzymes that modulate cellular glucose and glycogen levels; therefore, these proteins are suggested as potential targets for the treatment of diseases related to glycogen metabolism disorders...
September 16, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28913850/hyphenation-of-proton-transfer-reaction-mass-spectrometry-with-thermal-analysis-tg-ptr-ms-for-monitoring-the-thermal-degradation-of-retinyl-acetate
#8
Irene Peinado, Marco Mason, Franco Biasioli, Matteo Scampicchio
RATIONALE: The processing of retinyl acetate, a vitamin and biomarker, at high temperatures causes significant decomposition of the compound and thus loss of its activity. The rate of mass loss can be conveniently studied by thermogravimetry (TG). However, this technique generally fails to reveal which compounds have been evolved from the compound. In this work we propose a new hyphenation approach to continuously monitor the thermal decomposition of retinyl acetate and follow the evolution of specific volatile organic compounds (VOCs)...
September 14, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28912192/mechanical-cervical-ripening-for-women-with-prolongedpregnancies-magpop-protocol-for-a-randomised-controlled-trial-of-a-silicone-double-balloon-catheter-versus-the-propess-system-for-the-slow-release-of-dinoprostone-for-cervical-ripening-of-prolonged-pregnancies
#9
Caroline Diguisto, Amélie Le Gouge, Bruno Giraudeau, Franck Perrotin
INTRODUCTION: Induction of labour for prolonged pregnancies (PP) when the cervix is unfavourable is a challenging situation. Cervical ripening by pharmacological or mechanical techniques before oxytocin administration is used to increase the likelihood of vaginal delivery. Both techniques are equally effective in achieving vaginal delivery but excessive uterine activity, which induces fetal heart rate (FHR) anomalies, is more frequent after the pharmacological intervention. We hypothesised that mechanical cervical ripening could reduce the caesarean rate for non-reassuring FHR especially in PP where fetuses are already susceptible to this...
September 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28911258/effect-of-cryopreservation-on-cell-laden-hydrogels-comparison-of-different-cryoprotectants
#10
Nicola Cagol, Walter Bonani, Devid Maniglio, Claudio Migliaresi, Antonella Motta
Cell encapsulation in hydrogels is a technique that offers a variety of applications, ranging from drug delivery to biofabrication of three-dimensional scaffolds. The assembly of cell-laden hydrogel building blocks aims to generate complex biological constructs by manipulating microscale units. An important issue for the clinical implementation of this technique is the long-term storage of a large stock of cell/hydrogel building blocks. In this work, the impact of cryopreservation on the viability and functionality of cells encapsulated in alginate matrices is presented comparing different cryoprotective agents (CPAs)...
September 14, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28911239/controlled-release-of-liposome-encapsulated-temozolomide-for-brain-tumor-treatment-by-convection-enhanced-delivery
#11
Chung-Yin Lin, Rui-Jin Li, Chiung-Yin Huang, Kuo-Chen Wei, Pin-Yuan Chen
Convection-enhanced delivery (CED) is a promising technique for the delivery of drugs directly into the central nervous system (CNS) and, more specifically, the brain. CED can increase drug concentration within a brain tumor, thereby improving the therapeutic efficacy and limiting the systemic toxicity of tumoricidal agents. In this study, we evaluated a drug-liposome construct in vitro and in vivo using U87 tumor-bearing nude mice. Dipalmitoylphosphatidylcholine (DPPC)-based liposomes were designed to deliver a lipophilic temozolomide (TMZ) formulation (LipoTMZ)...
September 15, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28894267/optogenetic-approach-for-targeted-activation-of-global-calcium-transients-in-differentiated-c2c12-myotubes
#12
Stéphane Sebille, Oualid Ayad, Charles-Albert Chapotte-Baldacci, Christian Cognard, Patrick Bois, Aurélien Chatelier
Excitation-contraction coupling in muscle cells is initiated by a restricted membrane depolarization delimited within the neuromuscular junction. This targeted depolarization triggers an action potential that propagates and induces a global cellular calcium response and a consequent contraction. To date, numerous studies have investigated this excitation-calcium response coupling by using different techniques to depolarize muscle cells. However, none of these techniques mimic the temporal and spatial resolution of membrane depolarization observed in the neuromuscular junction...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28891586/poly-n-acryloyl-l-phenylalanine-methyl-ester-hollow-core-nanocapsules-facilitate-sustained-delivery-of-immunomodulatory-drugs-and-exhibit-adjuvant-properties
#13
Anil Kumar Yamala, Vinod Nadella, Yitzhak Mastai, Hridayesh Prakash, Pradip Paik
Polymeric hollow nanocapsules have attracted significant research attention as novel drug carriers and their preparation is of particular concern owing to the feasibility to encapsulate a broad range of drug molecules. This work presents for the first time the synthesis and development of novel poly-N-acryloyl l-phenylalanine methyl ester hollow core nanocapsules (NAPA-HPNs) of avg. size ca. 100-150 nm by the mini-emulsion technique. NAPA-HPNs are biocompatible and capable of encapsulating sodium nitroprusside (SNP) at a rate of ∼1...
September 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/28889103/a-new-diagnostic-resource-for-ceratitis-capitata-strain-identification-based-on-qtl-mapping
#14
Sheina B Sim, Raul Ruiz-Arce, Norman B Barr, Scott M Geib
The Mediterranean fruit fly Ceratitis capitata (Wiedemann) is a destructive agricultural pest and the subject of exclusion efforts in many countries. Suppression and eradication of invasive populations to prevent establishment is facilitated by the release of sterile males using the sterile insect technique (SIT). In active SIT release areas, it is critical to accurately discriminate between released sterile males and wild-caught individuals to be able to detect extremely rare invasive individuals in areas inundated with millions of sterile male flies...
September 9, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28888010/decoration-of-gold-nanoparticles-with-thiolated-ph-responsive-polymeric-peg-b-p-2-dimethylamio-ethyl-methacrylate-co-itaconic-acid-shell-a-novel-platform-for-targeting-of-anticancer-agent
#15
Marjan Ghorbani, Hamed Hamishehkar
The aim of this study was to design and develop a new pH-responsive nano-platform for controlled and targeted delivery of anticancer drugs. Engineering of pH-responsive nanocarriers was prepared via decoration of gold nanoparticles (NPs) by thiolated (methoxy-poly(ethylene glycol)-b-poly((2-dimethylamino) ethyl methacrylate-co-itaconic acid) (mPEG-b-p(DMAEMA-co-IA) copolymer and fully characterized by various techniques and subsequently used for loading and targeted delivery of anticancer agent, methotrexate (MTX)...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28887960/electrochemical-preparation-and-characterization-of-pnipam-hap-scaffolds-for-bone-tissue-engineering
#16
Charlene Aparecida Ribeiro, Marcos Vinicius Surmani Martins, Ana Helena Bressiani, José Carlos Bressiani, Maria Elena Leyva, Alvaro Antonio Alencar de Queiroz
In the last decade, a variety of methods for fabrication of three-dimensional biomimetic scaffolds based on hydrogels have been developed for tissue engineering. However, many methods require the use of catalysts which compromises the biocompatibility of the scaffolds. The electrochemical polymerization (ECP) of acrylic monomers has received an increased attention in recent years due to its versatility in the production of highly biocompatible coatings for the electrodes used in medical devices. The main aim of this work was the use of ECP as scaffold fabrication technique to produce highly porous poly(N-isopropylacrylamide) (PNIPAM)/hydroxyapatite (HAp) composite for bone tissue regeneration...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28887230/multiparticulate-system-combining-taste-masking-and-immediate-release-properties-for-the-aversive-compound-praziquantel
#17
Magdalena Münster, Corinna Schoch, Carsten Schmidt, Jörg Breitkreutz
The taste of pharmaceuticals is of particular importance as it highly affects the compliance of patients, especially for patient groups like children. In view of oral solid dosage forms, various taste masking techniques can be applied encapsulating the active pharmaceutical ingredient (API) to prevent the interaction with the taste buds. Despite a delayed drug release in saliva, an immediate drug release in gastrointestinal media is desirable for efficient drug absorption. This combinatory approach is of particular interest for poorly soluble drugs still demonstrating an aversive, bitter taste, e...
September 5, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28884739/-the-influence-of-the-main-components-of-the-ultraphonophoresis-phytocomplex-method-on-the-release-of-the-biologically-active-substances-an-experimental-study
#18
D V Babaskin, L I Babaskina, E A Abizov, O A Vasnetsova
The present study was designed to investigate kinetics of flavonoidrelease from the working compositions containing a phytocomplex. The basic parameters of this processes during phonophoresis were determined in the model in vitro experiments. The study has demonstrated the dependence of the flavonoid release rate on their initial concentration in the working compositions and the influence of dimethylsulfoxide (as well as the main and auxiliary agents of the working composition) on the release of biologically active substances...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/28884039/nanotechnology-based-combination-therapy-for-overcoming-multidrug-resistant-cancer
#19
Meng Zhang, Ergang Liu, Yanna Cui, Yongzhuo Huang
Multidrug resistance (MDR) is a major obstacle to successful cancer treatment and is crucial to cancer metastasis and relapse. Combination therapy is an effective strategy for overcoming MDR. However, the different pharmacokinetic (PK) profiles of combined drugs often undermine the combination effect in vivo, especially when greatly different physicochemical properties (e.g., those of macromolecules and small drugs) combine. To address this issue, nanotechnology-based codelivery techniques have been actively explored...
August 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28882767/optimization-of-alginate-microcapsules-containing-cells-overexpressing-%C3%AE-l-iduronidase-using-box-behnken-design
#20
Dirnete Diel, Valeska Lizzi Lagranha, Roselena Silvestri Schuh, Fernanda Bruxel, Ursula Matte, Helder Ferreira Teixeira
Mucopolysaccharidosis type I (MPS I) is an autosomal recessive disease caused by deficiency of α-l-iduronidase (IDUA), which results in the lysosomal accumulation of glycosaminoglycans (GAG) leading to widespread clinical manifestations. The microencapsulation of IDUA overexpressing recombinant cells has been considered as a promising strategy for the treatment of MPS I. This study aimed at the optimization of alginate microcapsules containing recombinant BHK (Baby Hamster Kidney) cells (rBHK) overexpressing IDUA produced by electrostatic extrusion technique...
September 4, 2017: European Journal of Pharmaceutical Sciences
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