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https://www.readbyqxmd.com/read/29142419/antipsoriatic-and-anti-inflammatory-studies-of-berberis-aristata-extract-loaded-nanovesicular-gels
#1
Nimisha, Dilshad Ali Rizvi, Zeeshan Fatima, Neema, Chanchal Deep Kaur
Objective: Novel nanovesicular gel of Berberis aristata extract was developed and evaluated for its anti-inflammatory and antipsoriatic activity. Materials and Methods: Transferosomes were prepared using soya phosphatidylcholine and edge activators (Tween 80, Span 80, and sodium deoxycholate) by a modified lipid film hydration technique using rotary evaporator and evaluated for various parameters. The quantification and standardization of extract have been carried out using its alkaloid content as berberine as biomarker...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142312/understanding-the-anticorrosive-protective-mechanisms-of-modified-epoxy-coatings-with-improved-barrier-active-and-self-healing-functionalities-eis-and-spectroscopic-techniques
#2
Demian I Njoku, Miaomiao Cui, Haigang Xiao, Baihui Shang, Ying Li
The present investigation adopted long-term in-situ electrochemical and spectroscopic approaches to study the combined active, self-healing and passive protective mechanisms of a new class of innovative anti-corrosive coatings based on epoxy doped with clay nanotubes impregnated with active species for the protection of carbon steel in 3.5% NaCl solution. The suitability of the as-received clay nanotubes to encapsulate the active agents was confirmed by different spectroscopic measurements. Tube end stopper with Ferric ion and polymer encapsulation with chitosan cross-linked with glutaraldehyde were adopted to tunnel the release of the active agents loaded into the nanotubes...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29142129/entry-of-human-coronavirus-nl63-to-the-cell
#3
Aleksandra Milewska, Paulina Nowak, Katarzyna Owczarek, Artur Szczepanski, Miroslaw Zarebski, Agnieszka Hoang-Bujnowicz, Krzysztof Berniak, Jacek Wojarski, Slawomir Zeglen, Zbigniew Baster, Zenon Rajfur, Krzysztof Pyrc
First steps of human coronavirus NL63 (HCoV-NL63) infection were previously described. The virus binds to target cells by heparan sulfate proteoglycans, and interacts with the ACE2 protein. Subsequent events, including virus internalization and trafficking, remain to be elucidated. In this study, we mapped the process of HCoV-NL63 entry into LLC-Mk2 cell line and ex vivo 3D tracheobronchial tissue.Using a variety of techniques we have shown that HCoV-NL63 virions require endocytosis for successful entry to the LLC-MK2 cells, and interaction between the virus and the ACE2 molecule triggers recruitment of clathrin...
November 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29140285/chitosan-cyclodextrin-tpp-nanoparticles-loaded-with-quercetin-as-novel-bacterial-quorum-sensing-inhibitors
#4
Hao Thanh Nguyen, Francisco M Goycoolea
The widespread emergence of antibiotic-resistant bacteria has highlighted the urgent need of alternative therapeutic approaches for human and animal health. Targeting virulence factors that are controlled by bacterial quorum sensing (QS), seems a promising approach. The aims of this study were to generate novel nanoparticles (NPs) composed of chitosan (CS), sulfo-butyl-ether-β-cyclodextrin (Captisol(®)) and/or pentasodium tripolyphosphate using ionotropic gelation technique, and to evaluate their potential capacity to arrest QS in bacteria...
November 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29138098/cytotoxic-activity-of-holothuria-tubulosa-echinodermata-coelomocytes
#5
Mirella Vazzana, Monica Celi, Marco Chiaramonte, Luigi Inguglia, Debora Russo, Vincenzo Ferrantelli, Dominique Battaglia, Vincenzo Arizza
The immune system of marine invertebrates, in particular that of holothurians, still requires further study. Our research showed that coelomocyte cells contained in the coelomic fluid of the sea cucumber, Holothuria tubulosa, are able to lyse, in vitro, red blood cells in rabbits and sheep. A plaque-forming assay showed spherule cells to be the effector cells, able to release cytotoxic molecules after xenogenic cell contact. The coelomocyte lysate supernatant, analysed by polyacrylamide gel electrophoresis overlay technique, using rabbit and sheep erythrocytes, showed two different haemolytic protein patterns: one calcium dependent and the other calcium independent...
November 12, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29134555/ciprofloxacin-loaded-calcium-alginate-wafers-prepared-by-freeze-drying-technique-for-potential-healing-of-chronic-diabetic-foot-ulcers
#6
Asif Ahmed, Giulia Getti, Joshua Boateng
Calcium alginate (CA) wafer dressings were prepared by lyophilization of hydrogels to deliver ciprofloxacin (CIP) directly to the wound site of infected diabetic foot ulcers (DFUs). The dressings were physically characterized by scanning electron microscopy (SEM), texture analysis (for mechanical and in vitro adhesion properties), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). Further, functional properties essential for wound healing, i.e., porosity, in vitro swelling index, water absorption (Aw), equilibrium water content (EWC), water vapor transmission rate (WVTR), evaporative water loss (EWL), moisture content, in vitro drug release and kinetics, antimicrobial activity, and cell viability (MTT assay) were investigated...
November 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29128975/transcutaneous-vagus-nerve-stimulation-tvns-modulates-flow-experience
#7
Lorenza S Colzato, Gina Wolters, Corinna Peifer
Flow has been defined as a pleasant psychological state that people experience when completely absorbed in an activity. Previous correlative evidence showed that the vagal tone (as indexed by heart rate variability) is a reliable marker of flow. So far, it has not yet been demonstrated that the vagus nerve plays a causal role in flow. To explore this we used transcutaneous vagus nerve stimulation (tVNS), a novel non-invasive brain stimulation technique that increases activation of the locus coeruleus (LC) and norepinephrine release...
November 11, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29128534/development-of-gelatin-ascorbic-acid-cryogels-for-potential-use-in-corneal-stromal-tissue-engineering
#8
Li-Jyuan Luo, Jui-Yang Lai, Shih-Feng Chou, Yi-Jen Hsueh, David Hui-Kang Ma
To offer an ideal hospitable environment for corneal keratocyte growth, the carrier materials can be functionalized with incorporation of signaling molecules to regulate cell biological events. This study reports, for the first time, the development of gelatin/ascorbic acid (AA) cryogels for keratocyte carriers in vitro and in vivo. The cryogel samples were fabricated by blending of gelatin with varying amounts of AA (0-300 mg) and carbodiimide cross-linking via cryogelation technique. Hydrophilic AA content in the carriers was found to significantly affect cross-linking degree and pore dimension of cryogels, thereby dictating their mechanical and biological stability and AA release profile...
November 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29121962/direct-interaction-with-14-3-3%C3%AE-promotes-surface-expression-of-best1-channel-in-astrocyte
#9
Soo-Jin Oh, Junsung Woo, Young-Sun Lee, Minhee Cho, Eunju Kim, Nam-Chul Cho, Jae-Yong Park, Ae Nim Pae, C Justin Lee, Eun Mi Hwang
BACKGROUND: Bestrophin-1 (Best1) is a calcium-activated anion channel (CAAC) that is expressed broadly in mammalian tissues including the brain. We have previously reported that Best1 is expressed in hippocampal astrocytes at the distal peri-synaptic regions, called microdomains, right next to synaptic junctions, and that it disappears from the microdomains in Alzheimer's disease mouse model. Although Best1 appears to be dynamically regulated, the mechanism of its regulation and modulation is poorly understood...
November 9, 2017: Molecular Brain
https://www.readbyqxmd.com/read/29118572/enhanced-antitumor-efficacy-of-poly-d-l-lactide-co-glycolide-based-methotrexate-loaded-implants-on-sarcoma-180-tumor-bearing-mice
#10
Li Gao, Lunyang Xia, Ruhui Zhang, Dandan Duan, Xiuxiu Liu, Jianjian Xu, Lan Luo
Purpose: Methotrexate is widely used in chemotherapy for a variety of malignancies. However, severe toxicity, poor pharmacokinetics, and narrow safety margin of methotrexate limit its clinical application. The aim of this study was to develop sustained-release methotrexate-loaded implants and evaluate antitumor activity of the implants after intratumoral implantation. Materials and methods: We prepared the implants containing methotrexate, poly(D,L-lactide-co-glycolide), and polyethylene glycol 4000 with the melt-molding technique...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29117434/co-culture-of-neurons-and-microglia
#11
Pamela J Roqué, Lucio G Costa
Microglia, the resident immune cells of the brain, have been implicated in numerous neurodegenerative and neurodevelopmental diseases. Activation of microglia by a variety of stimuli induces the release of factors, including pro- and anti-inflammatory cytokines and reactive oxygen species, that contribute to modulating neuro-inflammation and oxidative stress, two crucial processes linked to disorders of the central nervous system. The in vitro techniques described here will provide a set of protocols for the isolation and plating of primary cerebellar granule neurons, primary cortical microglia from a mixed glia culture, and methods for co-culturing both cell types...
November 8, 2017: Current Protocols in Toxicology
https://www.readbyqxmd.com/read/29117230/two-color-one-photon-uncaging-of-glutamate-and-gaba
#12
Stefan Passlick, Paul F Kramer, Matthew T Richers, John T Williams, Graham C R Ellis-Davies
Neuronal cells receive a variety of excitatory and inhibitory signals which they process to generate an output signal. In order to study the interaction between excitatory and inhibitory receptors with exogenously applied transmitters in the same preparation, two caging chromophores attached to glutamate and GABA were developed that were selectively photolyzed by different wavelengths of light. This technique has the advantage that the biologically inactive caged compound can be applied at equilibrium prior to the near instantaneous release of the transmitters...
2017: PloS One
https://www.readbyqxmd.com/read/29114332/molar-uprighting-a-considerable-and-safe-decision-to-avoid-prosthetic-treatment
#13
Taísa Boamorte Raveli, Dirceu Barnabé Raveli, Kelei Cristina de Mathias Almeida, Ary Dos Santos Pinto
Background: Tipped lower molar over edentulous space is very common in orthodontics practice when adults seek treatment. The segmented arch technique features a predictable force system that provides a controlled release of force that can produce light and continuous tooth movement. Case Description: A female adult patient, who lost a permanent lower first molar, needed correction of the position of her permanent first molar place. Instead of making space for rehabilitation, it was closed after second molar uprighting and a balanced interdigitation was created without prosthetics...
2017: Open Dentistry Journal
https://www.readbyqxmd.com/read/29110631/preparation-of-mesalamine-nanoparticles-using-a-novel-polyurethane-chitosan-graft-copolymer
#14
Farzad Mirabbasi, Abolghasem Moghimi, Shadab Shahsavari, Niloofar Babanejad, Simin Seifirad, Farid Dorkoosh
BACKGROUND: Chitosan nanoparticles have the potential to be used as hydrophilic carrier systems since they can deliver drugs to specific sites and control the drug release rate. Moreover, control released systems are designed to minimize systemic absorption and to achieve optimum delivery of the biologically active mesalamine to the distal small intestine and the colon. OBJECTIVE: The current study investigated the development of new nanoparticulate drug delivery systems based on polyurethane-chitosan copolymers...
November 3, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29107791/complexes-of-felodipine-nanoparticles-with-zein-prepared-using-a-dual-shift-technique
#15
Fuzheng Ren, Jinping Fu, Hui Xiong, Lin Cui, Guobin Ren, Haiying Guan, Qiufang Jing
To improve the dissolution of felodipine, felodipine-zein complexes were prepared using a dual shift technique, with zein as both stabilizer and carrier. The complexes were characterized by particle size, zeta potential, morphology, crystalline properties and release behavior. The complexes could be prepared in high yield and showed good redispersibility. The mean diameters of the felodipine particles in complexes were 150-300 nm, with negative zeta potentials of -30 mV to -25 mV after re-hydration, and the particle sizes of the complexes were in the range 10-80 μm...
October 28, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29107749/antioxidant-activity-and-controlled-drug-delivery-potential-of-tragacanth-gum-cl-poly-lactic-acid-co-itaconic-acid-hydrogel
#16
Vinod Kumar Gupta, Swadeep Sood, Shilpi Agarwal, Adesh K Saini, Deepak Pathania
Tragacanth gum-cl-poly (lactic acid-co-itaconic acid) (TG-cl-p(LA-co-IA)) hydrogel is synthesized through graft copolymerization reaction using microwave assisted technique. The synthesized hydrogel was characterised using various analytical and characterization techniques such as FTIR, FESEM, XRD, TGA, TEM and SEM. It was observed that, the maximum percentage swelling (Ps) of the hydrogel was 311.61% after 6h at room temperature and 298.06% after 3h at 60°C and TG-cl-p(LA-co-IA) exhibited highest Amoxicillin loading (73%) in double distilled waterafter 24h...
October 28, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29107049/environmentally-responsive-dual-targeting-nanoparticles-improving-drug-accumulation-in-cancer-cells-as-a-way-of-preventing-anticancer-drug-efflux
#17
Cenk Daglioglu
Drug targeting and stimuli-responsive drug release are two active areas of cancer research and hold tremendous potential in the management of cancer drug resistance. In this study, I addressed this issue and focused on the synthesis and characterization of pH-responsive Fe3O4@SiO2(FITC)-BTN/FA/DOX multifunctional nanoparticles aiming to increase drug accumulation in malignancies with both dual active targeting and endosomal drug release properties. Dye-doped silica magnetic-fluorescent composite was constructed by a simple co-precipitation of Fe(+2)/Fe(+3) salts followed by sol-gel formation and dual-targeting function was obtained by conjugating folate and biotin moieties on the silica surface of nanoparticles via an esterification reaction...
October 26, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29102699/self-assembled-phospholipid-based-phytosomal-nanocarriers-as-promising-platforms-for-improving-oral-bioavailability-of-the-anticancer-celastrol
#18
May S Freag, Wedad M Saleh, Ossama Y Abdallah
Celastrol (CST) is a promising natural drug of herbal origin that gained a great interest in the recent years by virtue of its wide variety of pharmacological actions. Nowadays, CST is extensively studied as a natural anticancer surrogate with a potential activity against various types of cancers. However, CST suffers from many limitations that handicapped its clinical utility such as limited aqueous solubility and poor gastrointestinal absorption which resulted into its low oral bioavailability. This work spotlights, for the first time, development of self-assembled phytosomal nanocarriers (CST-PHY) for improving CST solubility and oral bioavailability...
November 2, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29101975/chronic-exertional-compartment-syndrome-in-athletes
#19
REVIEW
Betty Liu, Gustavo Barrazueta, David E Ruchelsman
Chronic exertional compartment syndrome (CECS) refers to exercise-induced, reversible increases in pressure within well-defined inelastic fascial compartments leading to compromised tissue perfusion followed by functional loss, ischemic pain, and neurologic symptoms. Symptoms typically resolve when the activity ceases and there are usually no permanent sequelae. In the upper extremity, this condition most commonly affects athletes during sports requiring repetitive and vigorous gripping, such as rowers. In addition to clinical history and examination, a number of methods aid diagnosis, including compartment pressure measurements, magnetic resonance imaging, and near infrared spectroscopy...
November 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29097315/mapping-of-thalamic-magnetic-susceptibility-in-multiple-sclerosis-indicates-decreasing-iron-with-disease-duration-a-proposed-mechanistic-relationship-between-inflammation-and-oligodendrocyte-vitality
#20
Ferdinand Schweser, Ana Luiza Raffaini Duarte Martins, Jesper Hagemeier, Fuchun Lin, Jannis Hanspach, Bianca Weinstock-Guttman, Simon Hametner, Niels P Bergsland, Michael G Dwyer, Robert Zivadinov
Recent advances in susceptibility MRI have dramatically improved the visualization of deep gray matter brain regions and the quantification of their magnetic properties in vivo, providing a novel tool to study the poorly understood iron homeostasis in the human brain. In this study, we used an advanced combination of the recent quantitative susceptibility mapping technique with dedicated analysis methods to study intra-thalamic tissue alterations in patients with clinically isolated syndrome (CIS) and multiple sclerosis (MS)...
October 30, 2017: NeuroImage
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