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https://www.readbyqxmd.com/read/29916539/haus8-regulates-rlr%C3%A2-visa-antiviral-signaling-positively-by-targeting-visa
#1
Tian-Sheng He, Tian Chen, Dan-Dan Wang, Liang-Guo Xu
Mitochondrial anti‑viral signaling protein (VISA), additionally termed MAVS, IPS‑1 and Cardif, is located at the outer membrane of mitochondria and is an essential adaptor in the Rig‑like receptor (RLRs) signaling pathway. Upon viral infection, activated RLRs interact with VISA on mitochondria, forming a RLR‑VISA platform, leading to the recruitment of different TRAF family members, including TRAF3, TRAF2 and TRAF6. This results in the phosphorylation and nuclear translocation of interferon regulatory factors 3 and 7 (IRF3/IRF7) by TANK binding kinase 1 (TBK1) and/or IKKε, as well as activation of NF‑κB, to induce type I interferons (IFNs) and pro‑inflammatory cytokines...
June 15, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29915918/retinal-volume-change-is-a-reliable-oct-biomarker-for-disease-activity-in-neovascular-amd
#2
Claus von der Burchard, Felix Treumer, Christoph Ehlken, Stefan Koinzer, Konstantine Purtskhvanidze, Jan Tode, Johann Roider
PURPOSE: Current algorithms for automated computer interpretation of optical coherence tomography (OCT) imaging of patients suffering from neovascular age-related macular degeneration (AMD) mostly rely on fluid detection. However, fluid detection itself and correct interpretation of the fluid currently limits diagnostic accuracy. We therefore performed a detailed analysis of the requirements that would have to be met for fluid detection approaches. We further investigated if monitoring retinal volume would be a viable alternative to detect disease activity...
June 18, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29914850/treatment-with-tnf-%C3%AE-inhibitor-rectifies-m1-macrophage-polarization-from-blood-cd14-monocytes-in-patients-with-psoriasis-independent-of-stat1-and-irf-1-activation
#3
Shang-Hung Lin, Hung-Yi Chuang, Ji-Chen Ho, Chih-Hung Lee, Chang-Chun Hsiao
BACKGROUND: Psoriasis is a systemic inflammatory disease with dramatic responses to TNF-α inhibitors. TNF-α is mainly produced by macrophages. However, how macrophage polarization contributes to psoriasis remains unknown. OBJECTIVE: We aimed to investigate the molecular mechanisms of macrophage polarization in psoriasis. METHODS: 8 patients with moderate to severe psoriasis (Male/Female: 4/4, average age: 47.9 years old) and 8 healthy controls (Male/Female: 4/4, average age: 49...
May 29, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29907707/-leishmania-donovani-exploits-tollip-a-multitasking-protein-to-impair-tlr-il-1r-signaling-for-its-survival-in-the-host
#4
Naveen Parmar, Pragya Chandrakar, Preeti Vishwakarma, Kavita Singh, Kalyan Mitra, Susanta Kar
IL-1R/TLR signaling plays a significant role in sensing harmful foreign pathogens and mounting effective innate and adaptive immune responses. However, the precise mechanism by which Leishmania donovani, an obligate intramacrophagic pathogen, breaches IL-1R/TLR signaling and host-protective immunity remains obscure. In this study, we report the novel biphasic role of Toll-interacting protein (Tollip), a negative regulator of the IL-1R/TLR pathway, in the disease progression of experimental visceral leishmaniasis...
June 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29905681/time-domain-diffuse-correlation-spectroscopy-modeling-the-effects-of-laser-coherence-length-and-instrument-response-function
#5
Xiaojun Cheng, Davide Tamborini, Stefan A Carp, Oleg Shatrovoy, Bernhard Zimmerman, Danil Tyulmankov, Andrew Siegel, Megan Blackwell, Maria Angela Franceschini, David A Boas
Diffuse correlation spectroscopy (DCS) is an optical technique that non-invasively quantifies an index of blood flow (BFi ) by measuring the temporal autocorrelation function of the intensity fluctuations of light diffusely remitted from the tissue. Traditional DCS measurements use continuous wave (CW) lasers with coherence lengths longer than the photon path lengths in the sample to ensure that the diffusely remitted light is coherent and generates a speckle pattern. Recently, we proposed time domain DCS (TD-DCS) to allow measurements of the speckle fluctuations for specific path lengths of light through the tissue, which has the distinct advantage of permitting an analysis of selected long path lengths of light to improve the depth sensitivity of the measurement...
June 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29901286/echocardiographic-predictors-of-change-in-renal-function-with-intravenous-diuresis-for-decompensated-heart-failure
#6
Stephen A Gannon, Kenneth J Mukamal, James D Chang
AIMS: The aim of this study was to identify echocardiographic predictors of improved or worsening renal function during intravenous diuresis for decompensated heart failure. Secondary aim included defining the incidence and clinical risk factors for acute changes in renal function with decongestion. METHODS AND RESULTS: A retrospective review of 363 patients admitted to a single centre for decompensated heart failure who underwent intravenous diuresis and transthoracic echocardiography was conducted...
June 14, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29894743/effect-of-high-glucose-on-cytokine-production-by-human-peripheral-blood-immune-cells-and-type-i-interferon-signaling-in-monocytes-implications-for-the-role-of-hyperglycemia-in-the-diabetes-inflammatory-process-and-host-defense-against-infection
#7
Ronghua Hu, Chang-Qing Xia, Edward Butfiloski, Michael Clare-Salzler
The major metabolic feature of diabetes is hyperglycemia which has been linked to the diabetes inflammatory processes, and diabetes-related vulnerability to infection. In the present study, we assessed how glucose affected PBMCs in type I interferon (IFN) production and subsequent signaling. We found that the moderately elevated glucose promoted, and high glucose suppressed type I IFN production, respectively. Pre-exposure to high glucose rendered monocytes more sensitive to IFN-α stimulation with heightened signaling, whereas, instantaneous addition of high glucose did not exhibit such effect...
June 9, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29892288/a-positive-feedback-amplifier-circuit-that-regulates-interferon-ifn-stimulated-gene-expression-and-controls-type-i-and-type-ii-ifn-responses
#8
Agata Michalska, Katarzyna Blaszczyk, Joanna Wesoly, Hans A R Bluyssen
Interferon (IFN)-I and IFN-II both induce IFN-stimulated gene (ISG) expression through Janus kinase (JAK)-dependent phosphorylation of signal transducer and activator of transcription (STAT) 1 and STAT2. STAT1 homodimers, known as γ-activated factor (GAF), activate transcription in response to all types of IFNs by direct binding to IFN-II activation site (γ-activated sequence)-containing genes. Association of interferon regulatory factor (IRF) 9 with STAT1-STAT2 heterodimers [known as interferon-stimulated gene factor 3 (ISGF3)] or with STAT2 homodimers (STAT2/IRF9) in response to IFN-I, redirects these complexes to a distinct group of target genes harboring the interferon-stimulated response element (ISRE)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29889555/genetic-variation-in-the-h19-igf2-cluster-might-confer-risk-of-developing-impaired-renal-function
#9
Eliecer Coto, Carmen Díaz Corte, Salvador Tranche, Juan Gómez, Julián R Reguero, Belén Alonso, Sara Iglesias, Helena Gil-Peña, Xueqian Yin, Pablo Coto-Segura
The H19-IGF2 imprinted gene region could be implicated in the risk of developing impaired renal function (IRF). Our aim was to determine the association of several common H19-IGF2 variants and IRF in a cohort of elderly healthy individuals. The study involved 675 individuals >65 years of age, 184 with type 2 diabetes mellitus (T2DM), and 105 with IRF (estimated glomerular filtration rate [eGFR] <60). They were genotyped for two common H19 single nucleotide polymorphisms (SNPs) (rs2839698 and rs10732516), one H19-IGF2 intergenic indel (rs201858505), and one indel in the 3'UTR of the IGF2...
June 11, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29888789/morphometric-analysis-of-astrocytes-in-brainstem-respiratory-regions
#10
Shahriar Sheikhbahaei, Brian Morris, Jared Collina, Sommer Anjum, Sami Znati, Julio Gamarra, Ruli Zhang, Alexander V Gourine, Jeffrey C Smith
Astrocytes, the most abundant and structurally complex glial cells of the central nervous system, are proposed to play an important role in modulating the activities of neuronal networks, including respiratory rhythm-generating circuits of the preBötzinger complex (preBötC) located in the ventrolateral medulla of the brainstem. However, structural properties of astrocytes residing within different brainstem regions are unknown. In this study astrocytes in the preBötC, an intermediate reticular formation (IRF) region with respiratory-related function, and a region of the nucleus tractus solitarius (NTS) in adult rats were reconstructed and their morphological features were compared...
June 11, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29859222/acetyl-11-keto-%C3%AE-boswellic-acid-inhibits-the-secretion-of-cytokines-by-dendritic-cells-via-the-tlr7-8-pathway-in-an-imiquimod-induced-psoriasis-mouse-model-and-in-vitro
#11
Ming-Xing Wang, Jing-Xia Zhao, Yu-Jiao Meng, Ting-Ting Di, Xiao-Long Xu, Xiang-Jiang Xie, Yan Lin, Lu Zhang, Ning Wang, Ping Li, Yan Wang
AIMS: Psoriasis vulgaris is mediated by T and dendritic cells. This study aimed to investigate the effects of acetyl-11-keto-β-boswellic acid (AKBA) on activated dendritic cells (DCs) using an imiquimod (IMQ)-induced psoriasis-like mouse model and murine bone marrow-derived dendritic cells (BMDCs) stimulated with resiquimod (R848) in vitro. MATERIALS AND METHODS: The mice were treated with IMQ and intragastrically administered 25-100 mg/kg/day of AKBA, 1 mg/kg/day of methotrexate (MTX), or normal saline...
May 30, 2018: Life Sciences
https://www.readbyqxmd.com/read/29804893/using-promis-pain-interference-items-to-improve-quality-measurement-in-inpatient-rehabilitation-facilities
#12
Benjamin D Schalet, Michael A Kallen, Allen W Heinemann, Anne Deutsch, Karon F Cook, Linda Foster, David Cella
OBJECTIVE: To evaluate the Patient-Reported Outcomes Measurement Information System (PROMIS) pain interference items for use in a quality measure and to compare the resulting quality score, along with internal reliability and validity, to a similar item set in the Minimum Data Set Version 3.0 (MDS). DESIGN: Cross-sectional, observational study. SETTING: One freestanding inpatient rehabilitation facility (IRF) and one large hospital-based IRF...
May 24, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29797567/tank-binding-kinase-1-and-janus-kinase-2-play-important-roles-in-the-regulation-of-mitogen-activated-protein-kinase-phosphatase-1-expression-after-toll-like-receptor-4-activation
#13
Eunji Kim, Ju Y Yoon, Jongsung Lee, Deok Jeong, Jae G Park, Yo H Hong, Ji H Kim, Adithan Aravinthan, Jong-Hoon Kim, Jae Y Cho
Inflammation is a response that protects the body from pathogens. Through several inflammatory signaling pathways mediated by various families of transcription factors, such as nuclear factor-κB (NF-κB), activator protein-1 (AP-1), interferon regulatory factors (IRFs), and signal transducers and activators of transcription (STATs), various inflammatory cytokines and chemokines are induced and inflammatory responses are boosted. Simultaneously, inhibitory systems are activated and provide negative feedback...
May 24, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29791907/toll-like-receptor-3-signaling-contributes-to-regional-neutrophil-recruitment-in-cultured-human-glomerular-endothelial-cells
#14
Qiang Liu, Tadaatsu Imaizumi, Shogo Kawaguchi, Tomomi Aizawa, Tomoh Matsumiya, Shojiro Watanabe, Koji Tsugawa, Hidemi Yoshida, Kazushi Tsuruga, Kensuke Joh, Hiroshi Kijima, Hiroshi Tanaka
BACKGROUND: Given the importance of neutrophil recruitment in the pathogenesis of glomerulonephritis (GN), the representative neutrophil chemoattractant C-X-C motif chemokine 1 (CXCL1)/GROα and the adhesion molecule E-selectin in glomerular endothelial cells (GECs) play a pivotal role in the development of GN. Endothelial Toll-like receptor 3 (TLR3) is thought to be involved in the inflammatory response via innate immunity. However, the role of endothelial TLR3 signaling in the expression of neutrophil chemoattractants and adhesion molecules remains to be elucidated...
May 23, 2018: Nephron
https://www.readbyqxmd.com/read/29765016/b-cell-activation-and-plasma-cell-differentiation-are-inhibited-by-de-novo-dna-methylation
#15
Benjamin G Barwick, Christopher D Scharer, Ryan J Martinez, Madeline J Price, Alexander N Wein, Robert R Haines, Alexander P R Bally, Jacob E Kohlmeier, Jeremy M Boss
B cells provide humoral immunity by differentiating into antibody-secreting plasma cells, a process that requires cellular division and is linked to DNA hypomethylation. Conversely, little is known about how de novo deposition of DNA methylation affects B cell fate and function. Here we show that genetic deletion of the de novo DNA methyltransferases Dnmt3a and Dnmt3b (Dnmt3-deficient) in mouse B cells results in normal B cell development and maturation, but increased cell activation and expansion of the germinal center B cell and plasma cell populations upon immunization...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29760190/tick-borne-encephalitis-virus-nonstructural-protein-ns5-induces-rantes-expression-dependent-on-the-rna-dependent-rna-polymerase-activity
#16
Zifeng Zheng, Jieyu Yang, Xuan Jiang, Yalan Liu, Xiaowei Zhang, Mei Li, Mudan Zhang, Ming Fu, Kai Hu, Hanzhong Wang, Min-Hua Luo, Peng Gong, Qinxue Hu
Tick-borne encephalitis virus (TBEV) is one of the flaviviruses that targets the CNS and causes encephalitis in humans. The mechanism of TBEV that causes CNS destruction remains unclear. It has been reported that RANTES-mediated migration of human blood monocytes and T lymphocytes is specifically induced in the brain of mice infected with TBEV, which causes ensuing neuroinflammation and may contribute to brain destruction. However, the viral components responsible for RANTES induction and the underlying mechanisms remain to be fully addressed...
May 14, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29757957/arthroprotective-effects-of-cf-02-sharing-structural-similarity-with-quercetin
#17
Feng-Cheng Liu, Jeng-Wei Lu, Chiao-Yun Chien, Hsu-Shan Huang, Chia-Chung Lee, Shiu-Bii Lien, Leou-Chyr Lin, Liv Weichien Chen, Yi-Jung Ho, Min-Chung Shen, Ling-Jun Ho, Jenn-Haung Lai
In this study, we synthesized hundreds of analogues based on the structure of small-molecule inhibitors (SMIs) that were previously identified in our laboratory with the aim of identifying potent yet safe compounds for arthritis therapeutics. One of the analogues was shown to share structural similarity with quercetin, a potent anti-inflammatory flavonoid present in many different fruits and vegetables. We investigated the immunomodulatory effects of this compound, namely 6-(2,4-difluorophenyl)-3-(3-(trifluoromethyl)phenyl)-2 H -benzo[ e ][1,3]oxazine-2,4(3 H )-dione (Cf-02), in a side-by-side comparison with quercetin...
May 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29755465/irf3-negatively-regulates-toll-like-receptor-mediated-nf-%C3%AE%C2%BAb-signaling-by-targeting-trif-for-degradation-in-teleost-fish
#18
Xueyan Zhao, Ruixuan Huo, Xiaolong Yan, Tianjun Xu
NF-κB signaling is tightly regulated and essential to innate and adaptive immune responses, its regulatory mechanism remains unclear in various organisms, especially teleosts. In this study, we reported that IRF3 can negatively regulate TRIF-mediated NF-κB signaling pathway. Overexpression of IRF3 can inhibit TRIF-mediated NF-κB signaling pathway. However, knockdown of IRF3 had an opposite effect. IRF3 can promote the degradation of TRIF protein in mammal and fish cells, but this effect could be inhibited by MG132 treatment...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29753657/irf-1-rig-i-and-mda5-display-potent-antiviral-activities-against-norovirus-coordinately-induced-by-different-types-of-interferons
#19
Wen Dang, Lei Xu, Yuebang Yin, Sunrui Chen, Wenshi Wang, Mohamad S Hakim, Kyeong-Ok Chang, Maikel P Peppelenbosch, Qiuwei Pan
Norovirus represents the main cause of acute nonbacterial gastroenteritis worldwide. In immunocompromised patients, it bears high risk of causing chronic infection with significant morbidity and mortality. The lack of specific treatment prompts the development of anti-norovirus agents. In this study, we have investigated the role of interferon (IFN) response and evaluated antiviral activities of different IFNs against human norovirus (HuNoV) replication using a HuNoV replicon model. We found that HuNoV RNA replication was sensitive to all types of IFNs, including IFNα (type I), IFNγ (type II), IFNλ1 and 3 (type III)...
May 10, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29751576/thymoquinone-suppresses-irf-3-mediated-expression-of-type-i-interferons-via-suppression-of-tbk1
#20
Nur Aziz, Young-Jin Son, Jae Youl Cho
Interferon regulatory factor (IRF)-3 is known to have a critical role in viral and bacterial innate immune responses by regulating the production of type I interferon (IFN). Thymoquinone (TQ) is a compound derived from black cumin ( Nigella sativa L.) and is known to regulate immune responses by affecting transcription factors associated with inflammation, including nuclear factor-&kappa;B (NF-&kappa;B) and activator protein-1 (AP-1). However, the role of TQ in the IRF-3 signaling pathway has not been elucidated...
May 3, 2018: International Journal of Molecular Sciences
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