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https://www.readbyqxmd.com/read/29047170/irf-1-snps-influence-the-risk-for-childhood-allergic-asthma-a-critical-role-for-pro-inflammatory-immune-regulation
#1
Katja Landgraf-Rauf, Andreas Boeck, Diana Raedler, Elisabeth Klucker, Vanessa Vogelsang, Susanne Schmidt, Sonja Kunze, Claudia Weissenbacher, Anke Graessel, Carsten Schmidt-Weber, Erika von Mutius, Michaela Schedel, Bianca Schaub
BACKGROUND: Allergic and non-allergic childhood asthma has been characterized by distinct immune mechanisms. While interferon regulating factor 1 (IRF-1) polymorphisms (SNPs) influence atopy risk, the effect of SNPs on asthma phenotype-specific immune mechanisms is unclear. We assessed whether IRF-1 SNPs modify distinct immune regulatory pathways in allergic and non-allergic childhood asthma (AA/NA). METHODS: In the CLARA study, asthma was characterized by doctor's diagnosis and AA vs NA by positive or negative specific IgE...
October 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29046356/microrna-302a-suppresses-influenza-a-virus-stimulated-interferon-regulatory-factor-5-expression-and-cytokine-storm-induction
#2
Xueyuan Chen, Li Zhou, Nanfang Peng, Haisheng Yu, Mengqi Li, Zhongying Cao, Yong Lin, Xueyu Wang, Qian Li, Jun Wang, Yinglong She, Chengliang Zhu, Mengji Lu, Ying Zhu, Shi Liu
During influenza A virus (IAV) infection, cytokine storms play a vital and critical role in clinical outcomes. We have previously reported that microRNA (miR)-302c regulates IAV-induced IFN expression by targeting the 3'-UTR of nuclear factor kappa B (NF-κB)-inducing kinase (NIK). In the current study, we found that miR-302a, another member of miR-302 cluster, controls the IAV-induced cytokine storm. According to results from cell-based and knock-out mouse models, IAV induces a cytokine storm via interferon regulatory factor-5 (IRF-5)...
October 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29046345/endoplasmic-reticulum-transmembrane-proteins-zdhhc1-and-sting-both-act-as-direct-adaptors-for-irf3-activation-in-teleost
#3
Xiaowen Xu, Meifeng Li, Zhen Wu, Haizhou Wang, Liqiang Wang, Keyi Huang, Xiancheng Liu, Qunhao Hou, Gang Lin, Chengyu Hu
IFN regulatory factor (IRF)3 is a central regulator for IFN-β expression in different types of pathogenic infections. Mammals have various pathogenic sensors that are involved in monitoring pathogen intrusions. These sensors can trigger IRF3-mediated antiviral responses through different pathways. Endoplasmic reticulum-associated proteins stimulator of IFN gene (STING) and zinc finger DHHC-type containing 1 (ZDHHC1) are critical mediators of IRF3 activation in response to viral DNA infections. In this study, grass carp STING and ZDHHC1 were found to have some similar molecular features and subcellular localization, and both were upregulated upon stimulation with polyinosinic:polycytidylic acid, B-DNA, or Z-DNA...
October 18, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29040650/interferon-alpha-reduces-human-hippocampal-neurogenesis-and-increases-apoptosis-via-activation-of-distinct-stat1-dependent-mechanisms
#4
Alessandra Borsini, Annamaria Cattaneo, Chiara Malpighi, Sandrine Thuret, Neil A Harrison, Patricia A Zunszain, Carmine M Pariante
Background: In humans, interferon-α treatment for chronic viral hepatitis is a well-recognized clinical model for inflammation-induced depression, but the molecular mechanisms underlying these effects are not clear. Following peripheral administration in rodents, interferon-α induces signal transducer and activator of transcription-1 (STAT1) within the hippocampus and disrupts hippocampal neurogenesis. Methods: We used the human hippocampal progenitor cell line HPC0A07/03C to evaluate the effects of 2 concentrations of interferon-α, similar to those observed in human serum during its therapeutic use (500 pg/mL and 5000 pg/mL), on neurogenesis and apoptosis...
October 10, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29032836/the-impact-of-interferon-regulatory-factors-to-macrophage-differentiation-and-polarization-into-m1-and-m2
#5
REVIEW
Dimitry A Chistiakov, Veronika A Myasoedova, Victor V Revin, Alexander N Orekhov, Yuri V Bobryshev
The mononuclear phagocytes control the body homeostasis through the involvement in resolving tissue injury and further wound healing. Indeed, local tissue microenvironmental changes can significantly influence the functional behavior of monocytes and macrophages. Such microenvironmental changes for example occur in an atherosclerotic plaque during all progression stages. In response to exogenous stimuli, macrophages show a great phenotypic plasticity and heterogeneity. Exposure of monocytes to inflammatory or anti-inflammatory conditions also induces predominant differentiation to proinflammatory (M1) or anti-inflammatory (M2) macrophage subsets and phenotype switch between macrophage subsets...
October 5, 2017: Immunobiology
https://www.readbyqxmd.com/read/29032580/impact-of-ureteroscopy-before-radical-nephroureterectomy-for-upper-tract-urothelial-carcinomas-on-oncologic-outcomes-a-meta-analysis
#6
Run-Qi Guo, Peng Hong, Geng-Yan Xiong, Zhang Lei, Dong Fang, Xue-Song Li, Kai Zhang, Li-Qun Zhou
OBJECTIVES: To investigate whether ureteroscopy (URS) before radical nephroureterectomy (RNU) for upper tract urothelial carcinomas (UTUC) has an impact on oncologic outcomes. MATERIALS AND METHODS: We performed a systematic literature search of PubMed, Web of Science, and EMBASE for citations published prior to September 2017 that described URS performed on patients with UTUC and conducted a standard meta-analysis on survival outcomes. RESULTS: Our meta-analysis included eight eligible studies containing 3,975 patients...
October 15, 2017: BJU International
https://www.readbyqxmd.com/read/29032405/agaricus-blazei-murill-polysaccharides-protect-against-cadmium-induced-oxidative-stress-and-inflammatory-damage-in-chicken-spleens
#7
Wanqiu Xie, Ai Lv, Ruyue Li, Zequn Tang, Dexing Ma, Xiaodan Huang, Ruili Zhang, Ming Ge
Agaricus blazei Murill polysaccharide (ABP) has exhibited antioxidant and immunoregulatory activity. The aim of this study was to investigate the effect of ABP on cadmium (Cd)-induced antioxidant functions and inflammatory damage in chicken spleens. In this study, groups of 7-day-old chickens were fed with normal saline (0.2 mL single/day), CdCl2 (140 mg/kg/day), ABP (30 mg/mL, 0.2 mL single/day), and Cd + ABP (140 mg/kg/day + 0.2 mL ABP). Spleens were separated on the 20th, 40th, and 60th day for each group...
October 14, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29024475/bioengineered-lungs-generated-from-human-ipscs-derived-epithelial-cells-on-native-extracellular-matrix
#8
Mahboobe Ghaedi, Andrew V Le, Go Hatachi, Arkadi Beloiartsev, Kevin Rocco, Amogh Sivarapatna, Julio J Mendez, Pavlina Baevova, Rachel N Dyal, Katie L Leiby, Eric S White, Laura E Niklason
Controls on the spatiotemporal extent of groundwater flooding are poorly understood, despite the long duration of groundwater flood events and distinct social and economic impacts. We developed a novel approach using statistical analysis of groundwater level hydrographs and impulse response functions (IRFs) and applied it to the 2013/14 Chalk groundwater flooding in the English Lowlands. We proposed a standardised index of groundwater flooding which we calculated for monthly groundwater levels for 26 boreholes in the Chalk...
October 12, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28994461/implantable-cardioverter-defibrillator-in-elderly-predictors-of-appropriate-interventions-and-mortality-at-12-months-follow-up
#9
Sonia Ferretto, Alessandro Zorzi, Chiara Dalla Valle, Federico Migliore, Loira Leoni, Manuel De Lazzari, Domenico Corrado, Sabino Iliceto, Emanuele Bertaglia
BACKGROUND: The effectiveness of implantable cardioverter-defibrillator (ICD) in the elderly is uncertain, given their competing risk of non-arrhythmic death. Guidelines state that an ICD should be implanted if the expectation of survival is at least 1 year. However, survival is not easy to predict in elderly patients with severe cardiac disease. AIM: To assess 12-months survival after ICD implantation in patients aged ≥75 years, to identify predictors of 12-months mortality and to evaluate the incidence of ICD therapy during follow-up...
October 10, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28987803/long-acting-%C3%AE-2-adrenoreceptor-agonists-suppress-type-1-interferon-expression-in-human-plasmacytoid-dendritic-cells-via-epigenetic-regulation
#10
Chang-Hung Kuo, San-Nan Yang, Yi-Giien Tsai, Chong-Chao Hsieh, Wei-Ting Liao, Li-Chen Chen, Min-Sheng Lee, Hsuan-Fu Kuo, Ching-Hsiung Lin, Chih-Hsing Hung
The combination of inhaled long-acting β2-adrenoreceptor (LABA) and inhaled glucocorticoid (ICS) is a major therapy for asthma. However, the increased risk of infection is still a concern. Plasmacytoid dendritic cells (pDCs) are the predominant cells producing type 1 interferon (IFN) against infection. The effect of LABA/ICS on type 1 IFN expression in human pDCs is unknown. Circulating pDCs were isolated from healthy human subjects and were pretreated with glucocorticoid (GCS), LABA or a cAMP analog, and were stimulated with Toll-like receptor (TLR) agonist CpG (TLR9) or imiquimod (TLR7) in the presence of IL-3...
October 4, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28986447/innate-immune-recognition-of-double-stranded-rna-triggers-increased-expression-of-nkg2d-ligands-after-virus-infection
#11
Gloria Esteso, Susana Guerra, Mar Valés-Gómez, Hugh T Reyburn
Self/non-self discrimination by the innate immune system relies on germline-encoded, non-rearranging receptors expressed by innate immune cells recognizing conserved pathogen-associated molecular patterns. The natural killer group 2D (NKG2D) receptor is a potent immune-activating receptor that binds human genome-encoded ligands, whose expression is negligible in normal tissues, but increased in stress and disease conditions for reasons that are incompletely understood. Here it is not clear how the immune system reconciles receptor binding of self-proteins with self/non-self discrimination to avoid autoreactivity...
October 6, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28975621/role-of-interferon-regulatory-factor-1-in-governing-treg-depletion-th1-polarization-inflammasome-activation-and-antitumor-efficacy-of-cyclophosphamide
#12
Carla Buccione, Alessandra Fragale, Federica Polverino, Giovanna Ziccheddu, Eleonora Aricò, Filippo Belardelli, Enrico Proietti, Angela Battistini, Federica Moschella
The antitumor effectiveness of cyclophosphamide (CTX) and other chemotherapeutics was shown to rely not only on direct cytotoxicity but also on immunogenic tumor cell death and systemic immunomodulatory mechanisms, including regulatory T cell (Treg) depletion, Th1 cell polarization, type I interferon (IFN) and proinflammatory cytokine production. IFN regulatory factor (IRF)-1 is a transcriptional regulator of IFNs and IFN-inducible genes, involved in the control of Th1 and Treg differentiation and in sterile inflammation...
October 4, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28968468/irf-8-regulates-expansion-of-myeloid-derived-suppressor-cells-and-foxp3-regulatory-t-cells-and-modulates-th2-immune-responses-to-gastrointestinal-nematode-infection
#13
Rajesh M Valanparambil, Mifong Tam, Pierre-Paul Gros, Jean-Philippe Auger, Mariela Segura, Philippe Gros, Armando Jardim, Timothy G Geary, Keiko Ozato, Mary M Stevenson
Interferon regulatory factor-8 (IRF-8) is critical for Th1 cell differentiation and negatively regulates myeloid cell development including myeloid-derived suppressor cells (MDSC). MDSC expand during infection with various pathogens including the gastrointestinal (GI) nematode Heligmosomoides polygyrus bakeri (Hpb). We investigated if IRF-8 contributes to Th2 immunity to Hpb infection. Irf8 expression was down-regulated in MDSC from Hpb-infected C57BL/6 (B6) mice. IRF-8 deficient Irf8-/- and BXH-2 mice had significantly higher adult worm burdens than B6 mice after primary or challenge Hpb infection...
October 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28965738/post-acute-care-setting-facility-characteristics-and-post-stroke-outcomes-a-systematic-review
#14
REVIEW
Matthew Alcusky, Christine M Ulbrict, Kate L Lapane
OBJECTIVE: To synthesize research comparing post-stroke health outcomes between patients rehabilitated in skilled nursing facilities (SNFs) and inpatient rehabilitation facilities (IRFs). Secondly, to evaluate relationships between facility characteristics and outcomes. DATA SOURCES: PubMed and CINAHL searches spanned January 1, 1998 to October 6, 2016 and encompassed MeSH and free-text keywords for stroke, IRF/SNF, and study outcomes. Human and English limits were used...
September 28, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28963109/the-interferon-ifn-class-of-cytokines-and-the-ifn-regulatory-factor-irf-transcription-factor-family
#15
Hideo Negishi, Tadatsugu Taniguchi, Hideyuki Yanai
Interferons (IFNs) are a broad class of cytokines elicited on challenge to the host defense and are essential for mobilizing immune responses to pathogens. Divided into three classes, type I, type II, and type III, all IFNs share in common the ability to evoke antiviral activities initiated by the interaction with their cognate receptors. The nine-member IFN regulatory factor (IRF) family, first discovered in the context of transcriptional regulation of type I IFN genes following viral infection, are pivotal for the regulation of the IFN responses...
September 29, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28958606/is-profit-status-of-inpatient-rehabilitation-facilities-independently-associated-with-30-day-unplanned-hospital-readmission-for-medicare-beneficiaries
#16
Chih-Ying Li, Amol Karmarkar, Yu-Li Lin, Yong-Fang Kuo, Kenneth J Ottenbacher, James E Graham
OBJECTIVE: To investigate the effects of facility-level factors on 30-day unplanned risk-adjusted hospital readmission after Inpatient Rehabilitation Facilities (IRFs) discharge. DESIGN: We used the 100% Medicare claims data, covering 269,306 discharges from 1,094 IRFs between October 2010 and September 2011. We examined the association between hospital readmission and ten facility-level factors (number of discharges, disproportionate share percentage, profit status, teaching status, freestanding status, accreditation status, census region, stroke belt, location and median household income)...
September 25, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28928075/expression-and-functional-characterization-of-interferon-regulatory-factors-4-8-and-9-in-large-yellow-croaker-larimichthys-crocea
#17
Jingteng Tang, Lihua Jiang, Wei Liu, Bao Lou, Changwen Wu, Jianshe Zhang
Interferon regulatory factor (IRF)-4, 8, and 9 are essential in host defense against pathogens. Here, the full-length coding sequence (CDS), protein structure, and immune response of IRF4/8/9 (lc IRF4/8/9) were characterized in large yellow croaker (Larimichthys crocea). The open reading frame of lcIRF4, lcIRF8 and lcIRF9 encoded putative proteins of 463,422 and 406 amino acids, respectively. These IRFs share high sequence homology with other vertebrate IRFs and were constitutively expressed in all examined tissues...
September 18, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28923396/smac-mimetics-and-type-ii-interferon-synergistically-induce-necroptosis-in-various-cancer-cell-lines
#18
Michael John Cekay, Stefanie Roesler, Tanja Frank, Anne-Kathrin Knuth, Ines Eckhardt, Simone Fulda
Since cancer cells often evade apoptosis, induction of necroptosis as another mode of programmed cell death is considered a promising therapeutic alternative. Here, we identify a novel synergistic interaction of Smac mimetics that antagonize x-linked Inhibitor of Apoptosis (XIAP), cellular Inhibitor of Apoptosis (cIAP) 1 and 2 with interferon (IFN)γ to induce necroptosis in apoptosis-resistant cancer cells in which caspase activation is blocked. This synergism is confirmed by calculation of combination indices (CIs) and found in both solid and hematological cancer cell lines as well as for different Smac mimetics (i...
September 18, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28922378/relationships-of-orientation-discrimination-threshold-and-visual-acuity-with-macular-lesions-in-age-related-macular-degeneration
#19
Haojie Fu, Bin Zhang, Jianliang Tong, Harold Bedell, Hecheng Zhang, Yating Yang, Chaochao Nie, Yingdong Luo, Xiaoling Liu
PURPOSE: To measure visual acuity and metamorphopsia in patients with age-related macular degeneration (AMD) and to explore their relationship with macular lesions. METHODS: In this cross-sectional study, a total of 32 normal subjects (32 eyes) and 35 AMD patients (35 eyes) were recruited. They were categorized into 4 groups: normal, dry AMD, non-active wet AMD, and active wet AMD. Best-corrected visual acuity (BCVA) was measured using the Early Treatment Diabetic Retinopathy Study protocol...
2017: PloS One
https://www.readbyqxmd.com/read/28920002/ep4-antagonism-by-e7046-diminishes-myeloid-immunosuppression-and-synergizes-with-treg-reducing-il-2-diphtheria-toxin-fusion-protein-in-restoring-anti-tumor-immunity
#20
Diana I Albu, Zichun Wang, Kuan-Chun Huang, Jiayi Wu, Natalie Twine, Sarah Leacu, Christy Ingersoll, Lana Parent, Winnie Lee, Diana Liu, Renee Wright-Michaud, Namita Kumar, Galina Kuznetsov, Qian Chen, Wanjun Zheng, Kenichi Nomoto, Mary Woodall-Jappe, Xingfeng Bao
Reprogramming of immunosuppressive tumor microenvironment (TME) by targeting alternatively activated tumor associated macrophages (M2TAM), myeloid-derived suppressor cells (MDSC), and regulatory T cells (Tregs), represents a promising strategy for developing novel cancer immunotherapy. Prostaglandin E2 (PGE2), an arachidonic acid pathway metabolite and mediator of chronic inflammation, has emerged as a powerful immunosuppressor in the TME through engagement with one or more of its 4 receptors (EP1-EP4). We have developed E7046, an orally bioavailable EP4-specific antagonist and show here that E7046 has specific and potent inhibitory activity on PGE2-mediated pro-tumor myeloid cell differentiation and activation...
2017: Oncoimmunology
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