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https://www.readbyqxmd.com/read/29458094/a-conserved-interferon-regulation-factor-1-irf-1-from-pacific-oyster-crassostrea-gigas-functioned-as-an-activator-of-ifn-pathway
#1
Mengmeng Lu, Chuanyan Yang, Meijia Li, Qilin Yi, Guangxia Lu, Yichen Wu, Chen Qu, Lingling Wang, Linsheng Song
Interferon regulatory factors (IRFs), a family of transcription factors with a novel helix-turn-helix DNA-binding motif, play important roles in regulating the expression of interferons (IFNs) and IFN-stimulated genes. In the present study, an interferon regulation factor 1 was identified from oyster Crassostrea gigas (designated CgIRF-1), and its immune function was characterized to understand the regulatory mechanism of interferon system against viral infection in invertebrates. The open reading frame (ORF) of CgIRF-1 was 993 bp, encoding a polypeptide of 330 amino acids with a typical IRF domain (also known as DNA-binding domain)...
February 16, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29458009/the-lim-only-protein-fhl2-supports-influenza-a-virus-induced-lung-inflammation-by-restricting-the-host-adaptive-immune-response
#2
Dörthe Masemann, Rafael Leite Dantas, Siarhei Sitnik, Tanja Schied, Carolin Nordhoff, Stephan Ludwig, Viktor Wixler
FHL2 is a multifunctional adaptor protein with fine-tuning adjustment properties. It acts as a regulator of signaling cascades but also as a cofactor of transcription and controls several anti-inflammatory immune responses. Recently, we described FHL2 as a novel regulator of influenza A virus propagation. We have shown that in vitro FHL2 restricts viral replication by accelerating the IRF-3-dependent transcription of the Ifnb1 gene. In this work, we unraveled an ambiguous role of FHL2 during influenza A virus infection in vivo...
February 16, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29453856/defective-rna-sensing-by-rig-i-in-severe-influenza-virus-infection
#3
Sofie Eg Jørgensen, Mette Christiansen, Laura Barrett Ryø, Hans Henrik Gad, Jakob Gjedsted, Peter Staeheli, Jacob Giehm Mikkelsen, Merete Storgaard, Rune Hartmann, Trine Hyrup Mogensen
Influenza virus infection causes worldwide seasonal epidemics. Although influenza usually is a mild disease, a minority of patients experience very severe fulminating disease courses. Previous studies have demonstrated a role for type I interferon (IFN) in antiviral responses during influenza. However, IFN regulatory factor (IRF)7 deficiency is so far the only genetic cause of severe influenza described in humans. In this study we present a patient with severe influenza A virus (IAV) H1N1 infection during the 2009 Swine Flu pandemic...
February 17, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29449061/c4a-mrna-expression-in-pbmcs-predicts-the-presence-and-severity-of-delusions-in-schizophrenia-and-bipolar-disorder-with-psychosis
#4
Jennifer K Melbourne, Cherise Rosen, Benjamin Feiner, Rajiv P Sharma
Altered immune function is an established finding in psychotic disorders such as schizophrenia and bipolar disorder with psychosis, though its role in their development and progression remains to be understood. Evidence suggests altered JAK-STAT1 pathway activity in peripheral blood cells from participants with schizophrenia compared to controls. Activation of this pathway leads to increased expression of complement component 4A (C4A), which has recently been implicated in schizophrenia. Here, we examine mRNA expression of C4A in peripheral blood cells from participants with schizophrenia, bipolar disorder and controls...
February 12, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29448098/differences-in-tlr7-8-activation-between-monocytes-and-macrophages
#5
Hock-Liew Eng, Yuan-Ying Hsu, Tsun-Mei Lin
The recognition of single-stranded RNA by TLR7/8 leads to the production of NF-κB-mediated cytokines and type I IFNs. However, the role of TLR7/8 activation in monocytes and macrophages is still unclear. The aim of this study was to investigate the differences in the activation of TLR7/8 between these two cell types. Microarray analysis, qRT-PCR and flow cytometry were used to analyse TLR7/8 signalling pathways in monocytes and macrophages after stimulation with agonists. Our data indicated that TLR8 agonists activated the NF-κB- and IRF-mediated pathways in THP-1 cells, whereas TLR7 agonists did not...
February 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29444632/immunohistochemical-labeling-of-multiple-myeloma-oncogene-1-interferon-regulatory-factor-4-mum1-irf-4-in-canine-cutaneous-histiocytoma
#6
Justin M Stilwell, Daniel R Rissi
Multiple myeloma oncogene 1/interferon regulatory factor 4 (MUM1/IRF-4) immunohistochemistry (IHC) is mainly used for diagnostic confirmation of plasma cell tumors (PCTs) in dogs and cats. This article describes MUM1/IRF-4 IHC expression in 20 cases of canine cutaneous histiocytoma (CH) and compares it with 10 cutaneous or mucocutaneous PCTs and 5 cutaneous histiocytic sarcomas (HSs) submitted to the same IHC protocol. All histiocytomas had strong nuclear and variable cytoplasmic immunolabeling for MUM1/IRF-4, whereas all PCTs had strong nuclear and moderate cytoplasmic immunolabeling for MUM1/IRF-4...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29431896/on-taking-the-sting-out-of-immune-activation
#7
REVIEW
Andra Banete, Kyle Seaver, Devyani Bakshi, Katrina Gee, Sameh Basta
Nearly a decade ago, an endoplasmic reticulum (ER) adaptor protein called stimulator of interferon genes (STING) was found to be critical in the induction of type I IFN production in response to DNA virus infection. STING functions by sensing cytoplasmic DNA and activates key transcription factors, including IFN regulatory factor (IRF)-3 and IRF7, to initiate type I IFN expression. Type I IFNs are vital in immunity against viral infections and can influence cancer cell proliferation, migration, and apoptosis...
February 12, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29426390/lighting-as-a-compensatory-strategy-for-acquired-visual-deficits-after-stroke-two-case-reports
#8
Matthew Green, Beth Barstow, Laura Vogtle
OBJECTIVE: The objective of this article was to explore the effects of enhanced lighting on the function of people with an acquired visual deficit resulting from cerebrovascular accident (CVA) in an inpatient rehabilitation facility (IRF). METHOD: An ABAB design was used with two cases to assess how a short-term intervention involving lighting changes affected clients' grooming performance in an IRF. Analysis consisted of scores on the grooming section of the FIM®, times for each grooming task, and light meter readings...
March 2018: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/29423720/association-of-interferon-regulatory-factor-5-irf5-gene-polymorphisms-with-juvenile-idiopathic-arthritis
#9
Samira Esmaeili Reykande, Arezou Rezaei, Maryam Sadr, Mahsima Shabani, Farnaz Najmi Varzaneh, Vahid Ziaee, Nima Rezaei
Interferon regulatory factor 5 (IRF5) is a member of IRF family which induce signaling pathways and are involved in modulation of cell growth, differentiation, apoptosis, and immune system activity. Juvenile idiopathic arthritis (JIA) is an auto-inflammatory syndrome where the inflammatory markers are believed to play a fundamental role in its pathogenesis. In this study, we aimed to assess the association of IRF5 gene polymorphisms with susceptibility of JIA in Iranian population. Three IRF5 single-nucleotide polymorphisms (rs10954213 A/G, rs2004640 G/T, and rs3807306 G/T) were genotyped using TaqMan assays in 55 patients with JIA and 63 matched healthy individuals...
February 8, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29422611/decitibine-improve-the-efficiency-of-anti-pd-1-therapy-via-activating-the-response-to-ifn-pd-l1-signal-of-lung-cancer-cells
#10
Qi Lai, Haiyong Wang, Angui Li, Yinhui Xu, Liang Tang, Qiang Chen, Chunfang Zhang, Yang Gao, Jianfei Song, Zhenzong Du
IFN-γ-induced PD-L1 expression represents the existence of tumor-specific T cells, which predicts high-response rate to anti-PD-1/L1 therapy, but loss-of-function of IFN signals (e.g., JAK mutation) induces adaptive immune resistance in patients with low-response rate. Interferon regulatory factors (IRF) are frequently epigenetic silenced in carcinogenesis, while the role of methylation in anti-PD-1/L1 therapy remains unclear. We here investigated the methylation status of IFN-γ related genes IRF1/8 and IFN-α/β-related genes IRF3/7 in lung cancer tissues and found that only highly methylated IRF1 and 7 negatively correlated to cd274 (coding PD-L1) expression, similar to JAK mutation...
February 9, 2018: Oncogene
https://www.readbyqxmd.com/read/29421160/functional-elucidation-of-lvtoll-3-receptor-from-p-vannamei-through-rna-interference-and-its-potential-role-in-the-shrimp-antiviral-response
#11
David Angelo V Guanzon, Mary Beth B Maningas
There is a continuing debate on whether an antiviral immunity similar to vertebrate interferon response exists in invertebrates. Recent advances in penaeid immunology identified several new members of the Toll receptor family and one of these is LvToll3 (Litopenaeus vannamei Toll3). It is hypothesized in this study that LvToll3 responds to pathogen associated molecular patterns (PAMPs) such as dsRNA, which then activates certain antiviral pathways in penaeids. RNA interference (RNAi) was used to determine differences in the expression levels of specific genes putatively involved in the antiviral response through qPCR...
February 5, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29411775/respiratory-syncytial-virus-activates-epidermal-growth-factor-receptor-to-suppress-interferon-regulatory-factor-1-dependent-interferon-lambda-and-antiviral-defense-in-airway-epithelium
#12
A Kalinowski, B T Galen, I F Ueki, Y Sun, A Mulenos, A Osafo-Addo, B Clark, J Joerns, W Liu, J A Nadel, C S Dela Cruz, J L Koff
Respiratory syncytial virus (RSV) persists as a significant human pathogen that continues to contribute to morbidity and mortality. In children, RSV is the leading cause of lower respiratory tract infections, and in adults RSV causes pneumonia and contributes to exacerbations of chronic lung diseases. RSV induces airway epithelial inflammation by activation of the epidermal growth factor receptor (EGFR), a tyrosine kinase receptor. Recently, EGFR inhibition was shown to decrease RSV infection, but the mechanism(s) for this effect are not known...
February 7, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29411555/innate-immune-response-to-viral-infections-in-primary-bronchial-epithelial-cells-is-modified-by-the-atopic-status-of-asthmatic-patients
#13
Sylwia Moskwa, Wojciech Piotrowski, Jerzy Marczak, Małgorzata Pawełczyk, Anna Lewandowska-Polak, Marzanna Jarzębska, Małgorzata Brauncajs, Anna Głobińska, Paweł Górski, Nikolaos G Papadopoulos, Michael R Edwards, Sebastian L Johnston, Marek L Kowalski
PURPOSE: In order to gain an insight into determinants of reported variability in immune responses to respiratory viruses in human bronchial epithelial cells (HBECs) from asthmatics, the responses of HBEC to viral infections were evaluated in HBECs from phenotypically heterogeneous groups of asthmatics and in healthy controls. METHODS: HBECs were obtained during bronchoscopy from 10 patients with asthma (6 atopic and 4 non-atopic) and from healthy controls (n=9) and grown as undifferentiated cultures...
March 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29405769/thymoquinone-alleviates-the-experimentally-induced-alzheimer-s-disease-inflammation-by-modulation-of-tlrs-signaling
#14
Y S Abulfadl, N N El-Maraghy, Aa Eissa Ahmed, S Nofal, Y Abdel-Mottaleb, O A Badary
Alzheimer's disease (AD) is characterized by a robust inflammatory response elicited by the accumulation and deposition of amyloid-β (Aβ) within the brain. Aβ induces detrimental inflammatory responses through toll-like receptors (TLRs) signaling pathway. Thymoquinone (TQ), the main active constituent of Nigella sativa oil, has been reported by several previous studies for its potent anti-inflammatory effect. The aim of this study is to elucidate the effect of TQ in improving learning and memory, using a rat model of AD induced by a combination of aluminum chloride (AlCl 3 ) and d-galactose (d-Gal)...
January 1, 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29402958/cell-fate-in-antiviral-response-arises-in-the-crosstalk-of-irf-nf-%C3%AE%C2%BAb-and-jak-stat-pathways
#15
Maciej Czerkies, Zbigniew Korwek, Wiktor Prus, Marek Kochańczyk, Joanna Jaruszewicz-Błońska, Karolina Tudelska, Sławomir Błoński, Marek Kimmel, Allan R Brasier, Tomasz Lipniacki
The innate immune system processes pathogen-induced signals into cell fate decisions. How information is turned to decision remains unknown. By combining stochastic mathematical modelling and experimentation, we demonstrate that feedback interactions between the IRF3, NF-κB and STAT pathways lead to switch-like responses to a viral analogue, poly(I:C), in contrast to pulse-like responses to bacterial LPS. Poly(I:C) activates both IRF3 and NF-κB, a requirement for induction of IFNβ expression. Autocrine IFNβ initiates a JAK/STAT-mediated positive-feedback stabilising nuclear IRF3 and NF-κB in first responder cells...
February 5, 2018: Nature Communications
https://www.readbyqxmd.com/read/29402391/ifn-%C3%AE-and-tumor-gangliosides-implications-for-the-tumor-microenvironment
#16
Barbara Dillinger, Sarah Ahmadi-Erber, Manuel Lau, Markus A Hoelzl, Friedrich Erhart, Birgit Juergens, Dietmar Fuchs, Andreas Heitger, Stephan Ladisch, Alexander M Dohnal
Gangliosides shed by tumors into their microenvironment (TME) are immunoinhibitory. Interferon-γ (IFN-γ) may boost antitumor immune responses. Thus we wondered whether IFN-γ would counteract tumor ganglioside-mediated immune suppression. To test this hypothesis, we exposed human monocyte-derived LPS-activated dendritic cells (DC) to IFN-γ and to a highly purified ganglioside, GD1a. DC ganglioside exposure decreased TLR-dependent p38 signaling, explaining the previously observed ganglioside-induced down-modulation of pro-inflammatory surface markers and cytokines...
February 2, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29396179/corrigendum-to-oral-cancer-derived-exosomal-nap1-enhances-cytotoxicity-of-natural-killer-cells-via-the-irf-3-pathway-oral-oncol-76-2018-34-41
#17
Yingnan Wang, Xing Qin, Xueqin Zhu, Wanjun Chen, Jianjun Zhang, Wantao Chen
No abstract text is available yet for this article.
January 25, 2018: Oral Oncology
https://www.readbyqxmd.com/read/29391143/tgf-%C3%AE-smad-signaling-pathway-positively-up-regulates-the-differentiation-of-interleukin-9-producing-cd4-t-cells-in-human-echinococcus-granulosus-infection
#18
Nannan Pang, Fengbo Zhang, Shaoyu Li, Yuejie Zhu, Chuntao Zhang, Mengting An, Hongying Wang, Wulamu Mamuti, Jianbing Ding, Haining Fan
OBJECTIVES: Cystic echinococcosis (CE) is a zoonotic disease caused by Echinococcus granulosus (Eg) infection. Th9 cells are reported to be involved in the immune responses in CE patients. This study aims to investigate the role of TGF-β/Smad pathway in the regulation of Th9 cells in CE patients. METHODS: Using Western blot analysis, flow cytometry, qPCR, immunohistochemistry, ELISA and MTT assay, we measured the expression levels of TGF-β/Smad, PU.1, IRF-4, and IL-9 in CE patients...
January 29, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29386556/recombinant-mtb9-8-of-mycobacterium-bovis-stimulates-tnf-%C3%AE-and-il-1%C3%AE-secretion-by-raw264-7-macrophages-through-activation-of-nf-%C3%AE%C2%BAb-pathway-via-tlr2
#19
Shuqing Liu, Hong Jia, Shaohua Hou, Ting Xin, Xiaoyu Guo, Gaimei Zhang, Xintao Gao, Ming Li, Wuyang Zhu, Hongfei Zhu
The Mtb9.8 antigenic protein of Mycobacterium bovis/Mycobacterium tuberculosis has been identified as a target of the T-cell response. However, the interaction of Mtb9.8 with Toll-like receptors (TLRs) and the relevant signaling pathways have not been fully clarified. In this study, recombinant Mtb9.8 (rMtb9.8) derived from M. bovis-stimulated RAW264.7 cells initiated the secretion of TNF-α and IL-1β in a dose-dependent manner. Blocking assays show that TLR2-neutralizing antibody decreases the production of TNF-α and IL-1β...
January 31, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29385873/dysfunction-of-trim21-in-interferon-signature-of-systemic-lupus-erythematosus
#20
Reikou Kamiyama, Ryusuke Yoshimi, Mitsuhiro Takeno, Yasuhiro Iribe, Toshinori Tsukahara, Daiga Kishimoto, Yosuke Kunishita, Yumiko Sugiyama, Naomi Tsuchida, Hiroto Nakano, Kaoru Minegishi, Maasa Tamura, Yukiko Asami, Yohei Kirino, Yoshiaki Ishigatsubo, Keiko Ozato, Hideaki Nakajima
OBJECTIVES: TRIM21 is an E3 ubiquitin ligase for interferon regulatory factors (IRFs) that are involved in innate and acquired immunity. Here we evaluated the role of TRIM21 in the interferon (IFN) signature of systemic lupus erythematosus (SLE). METHODS: Twenty SLE patients and 24 healthy controls were enrolled in this study. We analyzed mRNA expression of TRIM21, type I IFN, and IFN-inducible genes in peripheral blood mononuclear cell (PBMCs). The protein levels of IRFs were assessed by Western blotting in PBMCs cultured with or without MG-132...
February 1, 2018: Modern Rheumatology
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