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https://www.readbyqxmd.com/read/28743100/studies-on-secondary-metabolite-profiling-anti-inflammatory-potential-in-vitro-photoprotective-and-skin-aging-related-enzyme-inhibitory-activities-of-malaxis-acuminata-a-threatened-orchid-of-nutraceutical-importance
#1
Biswajit Bose, Hiranjit Choudhury, Pramod Tandon, Suman Kumaria
Malaxis acuminata D. Don., a small, terrestrial orchid, is endemic to tropical Himalayas at an altitude of 1200-2000m asl. The dried pseudobulbs are important ingredients of century old ayurvedic drug 'Ashtavarga' and a polyherbal immune-booster nutraceutical 'Chyavanprash', known to restore vigour, vitality and youthfulness. Considering tremendous medicinal importance of this threatened orchid species, a detailed study was undertaken for the first time to address its antioxidant potential, secondary metabolite contents and biological activities against skin-aging related enzymes (anti-collagenase, anti-elastase, anti-tyrosinase and xanthine oxidase) and anti-inflammatory activity (5-lipoxygenase and hyaluronidase) in different plant parts of wild and in vitro-derived plants of M...
July 12, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28743082/characterization-and-evaluation-of-nanoencapsulated-diethylcarbamazine-in-model-of-acute-hepatic-inflammation
#2
Gabriel Barros Rodrigues, Elquio Eleamen Oliveira, Francisco Jaime Bezerra Mendonça Junior, Laise Aline Martins Dos Santos, Wilma Helena de Oliveira, Maria Eduarda Rocha de França, Deniele Bezerra Lós, Brennda Martins Gabínio, Fábia Cristiane Melo Leite de Lira, Christina Alves Peixoto
Previous studies from our laboratory have demonstrated that Diethylcarbamazine (DEC) is a potent anti-inflammatory drug. The aim of the present study was to characterize the nanoencapsulation of DEC and to evaluate its effectiveness in a model of inflammation for the first time. C57BL/6 mice were divided into six groups: 1) Control; 2) Carbon tetrachloride (CCl4); 3) DEC 25mg/kg+CCl4; 4) DEC 50mg/kg+CCl4; 5) DEC-NANO 05mg/kg+CCl4 and 6) DEC-NANO 12.5mg/kg+CCl4. Liver fragments were stained with hematoxylin-eosin, and processed for Western blot, ELISA and immunohistochemistry...
July 22, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28742624/impact-of-a-mandated-change-in-buprenorphine-formulation
#3
Ryan Graddy, Darius A Rastegar
OBJECTIVE: This study examines the impact of an insurance-mandated change in formulation of buprenorphine/naloxone (BNX) for patients with opioid use disorder treated in a primary care clinic. METHODS: A retrospective cohort study was conducted to determine the proportion of patients who were switched back to the previous BNX formulation and rates of aberrant urine drug tests for the 3 months before and 3 months after a mandated change in BNX from the sublingual film to the rapidly dissolving tablet (BNX-RDT)...
July 24, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28741139/characterization-of-a-liquid-crystal-system-for-sustained-release-of-a-peptide-bms-686117
#4
Yan Xu, Vivian Li, Jinjiang Li, Duohai Pan, Gerd Langenbucher, Neil Mathias
Liquid crystal lipid-based formulations are an effective approach to prolong pharmacokinetics and reduce burst release of a drug on subcutaneous delivery. The objective of this paper was to investigate the influence of phase structures of a lipid-based liquid crystal delivery system and its associated mechanical properties on the release profile of a peptide. It was hypothesized that release of drug molecules are closely related to the mechanical properties that are controlled by phase structures. Experimentally, the relationship between phase structures of lipid liquid crystal system-soy phosphatidyl choline (SPC) and glycerol dioleate (GDO) in water were characterized by polarized light microscopy and small angle X-ray diffraction...
July 24, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28741064/injectable-sustained-release-depots-of-plga-microspheres-for-insoluble-drugs-prepared-by-hot-melt-extrusion
#5
Yuting Guo, Yunning Yang, Luying He, Rong Sun, Chenguang Pu, Bin Xie, Haibing He, Yu Zhang, Tian Yin, Yanjiao Wang, Xing Tang
PURPOSE: Progesterone (PRG) was selected as a model drug to develop a long-acting injection system for poorly water-soluble drugs. METHODS: Microspheres with high density-low porosity were prepared by hot-melt extrusion (HME) combined with wet-milling as the representative formulation, and a microcrystal suspension was also studied as a comparison. The morphology, particle size and distribution, polymorphism, drug distribution, density and porosity were characterized by scanning electron microscopy, laser diffraction particle size analyzer, power X-ray diffraction and DSC respectively...
July 24, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28740519/low-dose-diclofenac-in-patients-with-fragility-fractures
#6
Letizia Vannucci, Caterina Fossi, Giorgio Gronchi, Maria Luisa Brandi
Most osteoporotic patients complain of back pain one year after a fragility vertebral fracture and the frequency of chronic back pain increases with increasing age. The use of the lowest effective dose of an analgesic which is able to control symptoms seems to be a possible solution in order to limit potential side effects in multi-treated elderly patients. Non-steroidal anti-inflammatory drugs (NSAIDs) have a proven efficacy in the treatment of back pain associated with fragility vertebral fractures and diclofenac is available at low-dose subcutaneous injective formulation...
January 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28740426/efficacy-of-flurbiprofen-8-75-mg-delivered-as-a-spray-or-lozenge-in-patients-with-sore-throat-due-to-upper-respiratory-tract-infection-a-randomized-non-inferiority-trial-in-the-russian-federation
#7
Eugenia Radkova, Natalia Burova, Valeria Bychkova, Robert DeVito
OBJECTIVE: To assess the efficacy of flurbiprofen 8.75 mg delivered as a spray or lozenge in patients with sore throat due to upper respiratory tract infection (URTI). MATERIALS AND METHODS: This multicenter, double-blind, double-dummy, non-inferiority study randomized 440 adults with recent-onset, moderate-to-severe sore throat due to URTI to a single dose of either flurbiprofen 8.75 mg spray (n=218) or flurbiprofen 8.75 mg lozenge (n=222). The presence or absence of beta-hemolytic streptococci (A or C) was confirmed by culture tests (throat swab)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28740381/chitosan-coated-diacerein-nanosuspensions-as-a-platform-for-enhancing-bioavailability-and-lowering-side-effects-preparation-characterization-and-ex-vivo-in-vivo-evaluation
#8
Ahmed N Allam, Sherif I Hamdallah, Ossama Y Abdallah
Nanodrug delivery systems have been widely reviewed for their use in several drug formulations to improve bioavailability, sustain effect, and decrease side effects of many candidate drugs. The objective of this study was to evaluate the potential of chitosan (CS)-coated nanosuspensions to enhance bioavailability and reduce the diarrheal side effect of diacerein (DCN) after oral administration. DCN nanosuspensions (DNS) were prepared by sonoprecipitation technique using different stabilizers at three different concentrations...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28739783/effect-of-rifampin-on-the-single-dose-pharmacokinetics-of-oral-cabotegravir-in-healthy-subjects
#9
S L Ford, K Sutton, Y Lou, Z Zhang, A Tenorio, C Trezza, P Patel, W Spreen
Introduction: Drug-drug interactions between antiretroviral medications and rifampin complicate the treatment of HIV and tuberculosis coinfection. This study evaluated the effect of rifampin on the pharmacokinetics of oral cabotegravir, an integrase strand transfer inhibitor being investigated for long-acting treatment and prevention of HIV-1 infection.Methods: This was a phase I, single-center, open-label, fixed-sequence crossover study in healthy adults. The objective was to evaluate the effect of steady-state rifampin on the single-dose plasma pharmacokinetics of cabotegravir...
July 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28739502/development-of-biomedical-5-fluorouracil-nanoplatforms-for-colon-cancer-chemotherapy-influence-of-process-and-formulation-parameters
#10
Elena Pretel, José L Arias, Laura Cabeza, Consolación Melguizo, José C Prados, Mireia Mallandrich, Joaquim Suñer, Beatriz Clares
In the present investigation solvent displacement or nanoprecipitation, and double emulsion/solvent evaporation methods were utilized to optimize poly(D,L-lactide-co-glycolide) nanoparticles for the vehiculization of the 5-fluorouracil. Formulation components from both the aqueous and organic phases, as well as, operating conditions were varied. Particles were characterized in terms of particle size and morphology, electrical properties, rheology, drug loading, stability, and drug release. Furthermore, in vitro cytotoxicity on human colon cells and different colon carcinoma cells was evaluated...
July 21, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28739038/anesthetic-and-perioperative-management-of-patients-with-brugada-syndrome
#11
REVIEW
Gregory Dendramis, Claudia Paleologo, Giuseppe Sgarito, Umberto Giordano, Roberto Verlato, Adrian Baranchuk, Pedro Brugada
Brugada syndrome (BrS) is an arrhythmogenic disease reported to be one among the leading causes of cardiac death in subjects under the age of 40 years. In these patients, episodes of lethal arrhythmias may be induced by several factors or situations, and for this reason, management during anesthesia and surgery must provide some precautions and drugs restrictions. To date, it is difficult to formulate guidelines for anesthetic management of patients with BrS because of the absence of prospective studies, and there is not a definite recommendation for neither general nor regional anesthesia, and there are no large studies in merit...
June 28, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28738516/one-pot-synthesis-of-three-dimensional-mn3o4-microcubes-for-high-level-sensitive-detection-of-head-and-neck-cancer-drug-nimorazole
#12
Rajaji Umamaheswari, Muthumariappan Akilarasan, Shen-Ming Chen, Yi-Hui Cheng, Veerappan Mani, Sakthivel Kogularasu, Fahad M A Al-Hemaid, M Ajmal Ali, Xiaoheng Liu
We described a three-dimensional Mn3O4 microcubes (3D-Mn3O4MCs) synthesised via a facile hydrothermal route for the determination of nimorazole (NMZ), an important drug that used in the treatment of head and neck cancer. The 3D-Mn3O4 MCs possess large active area and high conductivity, and 3D-Mn3O4 MCs film modified screen-printed carbon electrode (3D-Mn3O4MCs/SPCE) was fabricated which displayed excellent electrocatalytic ability towards NMZ. Under optimised working conditions, the modified electrode responded linearly to NMZ in the 0...
July 4, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28738440/issr-derived-species-specific-scar-marker-for-rapid-and-accurate-authentication-of-ocimum-tenuiflorum-l
#13
Amit Kumar, Vereena Rodrigues, Priyanka Mishra, Kuppusamy Baskaran, Ashutosh K Shukla, Ajit K Shasany, Velusamy Sundaresan
Ocimum tenuiflorum has been widely used in traditional medicine and has high medicinal value. High volume trade of this potential medicinal plant species led to unscrupulous adulteration of both crude drugs as well as formulations. Morphology-based authentication is difficult in cases of incomplete or damaged samples and in dried herbal materials. In such cases, PCR-based molecular methods may aid in accurate identification. The present study aimed at developing species-specific DNA marker(s) for the authentication of O...
July 24, 2017: Planta Medica
https://www.readbyqxmd.com/read/28738427/nanoemulsion-an-advanced-vehicle-for-efficient-drug-delivery
#14
Asad Ali, Vaseem Ahamad Ansari, Usama Ahmad, Juber Akhtar, Afroz Jahan
Advanced drug delivery system has now gained preference over the conventional drug delivery system. One such research is nanoemulsion which is famous among the researchers because of ease of formation, stability, clarity, increased absorption rate leading to increasing in bioavailability and potential to form a formulation with both lipophilic as well as the hydrophilic drug. Long lasting stability (up to years) and ability to encapsulate both lipophilic and hydrophilic drug has given this colloidal system a valuable position in drug delivery...
July 24, 2017: Drug Research
https://www.readbyqxmd.com/read/28738158/efficient-interfacially-driven-vehiculization-of-corticosteroids-by-pulmonary-surfactant
#15
Alberto Hidalgo, Fabrizio Salomone, Nieves Fresno, Guillermo Orellana, Antonio Cruz, Jesus Perez-Gil
Pulmonary surfactant is a crucial system to stabilize the respiratory air-liquid interface. Furthermore, pulmonary surfactant has been proposed as an effective method for targeting drugs to the lungs. However, few studies have examined in detail the mechanisms of incorporation of drugs into surfactant, the impact of the presence of drugs on pulmonary surfactant performance at the interface under physiologically-meaningful conditions, or the ability of pulmonary surfactant to use the air-liquid interface to vehiculise drugs to long distances...
July 24, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28737435/investigation-on-influence-of-wurster-coating-process-parameters-for-development-of-delayed-release-minitablets-of-naproxen
#16
Neha Shah, Rahul Aware, Vasant Shetty, Tejal Mehta
The present work aims at studying process parameters affecting coating of minitablets (3 mm in diameter) through Wurster coating process. Minitablets of Naproxen with high drug loading were manufactured using 3 mm multi-tip punches. The release profile of core pellets (published) and minitablets was compared with that of marketed formulation. The core formulation of minitablets was found to show similarity in dissolution profile with marketed formulation and hence was further carried forward for functional coating over it...
July 24, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28737406/preclinical-effect-of-absorption-modifying-excipients-on-rat-intestinal-transport-of-five-model-compounds-and-the-intestinal-barrier-marker-51-cr-edta
#17
David Dahlgren, Carl Roos, Anders Lundqvist, Peter Langguth, Christer Tannergren, Markus Sjöblom, E Sjögren, H Lennernas
There is a renewed interest from the pharmaceutical field to develop oral formulations of compounds such as peptides, oligonucleotides, and polar drugs. However, these often suffer from insufficient absorption across the intestinal mucosal barrier. One approach to circumvent this problem is the use of absorption modifying excipient(s) (AME). This study determined the absorption enhancing effect of four AMEs (sodium dodecyl sulfate, caprate, chitosan, N-acetylcysteine) on five model compounds in a rat jejunal perfusion model...
July 24, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28737403/validation-of-dissolution-testing-with-biorelevant-media-an-orbito-study
#18
James Mann, Jennifer B Dressman, Karin Rosenblatt, Lee Ashworth, Uwe Muenster, Kerstin Frank, Paul Hutchins, James Williams, Lukas Klumpp, Kristina Wielockx, Philippe Berben, Patrick Augustijns, Rene Holm, Michael Hofmann, Sanjaykumar Patel, Stefania Beato, Krista Ojala, Irena Tomaszewska, Jean-Luc Bruel, James Butler
BACKGROUND: Dissolution testing with biorelevant media has become widespread in the pharmaceutical industry as a means of better understanding how drugs and formulations behave in the gastrointestinal tract. Until now, however, there have been few attempts to gauge the reproducibility of results obtained with these methods. PURPOSE: The aim of this study was to determine the inter-laboratory reproducibility of biorelevant dissolution testing, using the paddle apparatus (USP 2)...
July 24, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28737398/in-vivo-mechanisms-of-intestinal-drug-absorption-from-aprepitant-nanoformulations
#19
Carl Roos, David Dahlgren, Staffan Berg, Jan Westergren, Bertil Abrahamsson, Christer Tannergren, E Sjögren, H Lennernas
Over recent decades there has been an increase in the proportion of BCS class II and IV drug candidates in industrial drug development. To overcome the biopharmaceutical challenges associated with the less favorable properties of solubility and/or intestinal permeation of these substances, the development of formulations containing nanosuspensions of the drugs has been suggested. The intestinal absorption of aprepitant from two nanosuspensions (20 µM and 200 µM total concentrations) in phosphate buffer, one nanosuspension (200 µM) in fasted-state simulated intestinal fluid (FaSSIF), and one solution (20 µM) in FaSSIF was investigated in the rat single-pass intestinal perfusion model...
July 24, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28737128/bioequivalence-of-two-oseltamivir-formulations-in-healthy-chinese-volunteers%C3%A2
#20
Yun-Lei Yun, Shou-Hong Gao, Yan Wen, Zhi-Peng Wang, Hai-Jun Miao, Wan-Sheng Chen
BACKGROUND: The aim of this study was to compare the bioavailability of a new generic formulation of oseltamivir 75-mg capsule (test) and a branded formulation Tamiflu® (reference) to meet regulatory criteria for marketing the test product in healthy Chinese male volunteers. METHODS: This single-dose, randomized-sequence, open-label, two-period crossover study was conducted in fasted healthy Chinese male volunteers, who first received a single oral dose of the test or reference formulation with a 7-day washout period, and then the alternative formulation...
July 24, 2017: International Journal of Clinical Pharmacology and Therapeutics
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