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https://www.readbyqxmd.com/read/29149325/the-iuphar-bps-guide-to-pharmacology-in-2018-updates-and-expansion-to-encompass-the-new-guide-to-immunopharmacology
#1
Simon D Harding, Joanna L Sharman, Elena Faccenda, Chris Southan, Adam J Pawson, Sam Ireland, Alasdair J G Gray, Liam Bruce, Stephen P H Alexander, Stephen Anderton, Clare Bryant, Anthony P Davenport, Christian Doerig, Doriano Fabbro, Francesca Levi-Schaffer, Michael Spedding, Jamie A Davies
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, www.guidetopharmacology.org) and its precursor IUPHAR-DB, have captured expert-curated interactions between targets and ligands from selected papers in pharmacology and drug discovery since 2003. This resource continues to be developed in conjunction with the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS). As previously described, our unique model of content selection and quality control is based on 96 target-class subcommittees comprising 512 scientists collaborating with in-house curators...
November 15, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29149040/a-coap-based-network-access-authentication-service-for-low-power-wide-area-networks-lo-coap-eap
#2
Dan Garcia-Carrillo, Rafael Marin-Lopez, Arunprabhu Kandasamy, Alexander Pelov
The Internet-of-Things (IoT) landscape is expanding with new radio technologies. In addition to the Low-Rate Wireless Personal Area Network (LR-WPAN), the recent set of technologies conforming the so-called Low-Power Wide Area Networks (LP-WAN) offers long-range communications, allowing one to send small pieces of information at a reduced energy cost, which promotes the creation of new IoT applications and services. However, LP-WAN technologies pose new challenges since they have strong limitations in the available bandwidth...
November 17, 2017: Sensors
https://www.readbyqxmd.com/read/29138947/a-posteriori-metadata-from-automated-provenance-tracking-integration-of-aiida-and-tcod
#3
Andrius Merkys, Nicolas Mounet, Andrea Cepellotti, Nicola Marzari, Saulius Gražulis, Giovanni Pizzi
In order to make results of computational scientific research findable, accessible, interoperable and re-usable, it is necessary to decorate them with standardised metadata. However, there are a number of technical and practical challenges that make this process difficult to achieve in practice. Here the implementation of a protocol is presented to tag crystal structures with their computed properties, without the need of human intervention to curate the data. This protocol leverages the capabilities of AiiDA, an open-source platform to manage and automate scientific computational workflows, and the TCOD, an open-access database storing computed materials properties using a well-defined and exhaustive ontology...
November 14, 2017: Journal of Cheminformatics
https://www.readbyqxmd.com/read/29137174/hdomo-smart-sensor-integration-for-an-active-and-independent-longevity-of-the-elderly
#4
Emanuele Frontoni, Rama Pollini, Paola Russo, Primo Zingaretti, Graziano Cerri
The aim of this paper is to present the main results of HDOMO, an Ambient Assisted Living (AAL) project that involved 16 Small and Medium Enterprises (SMEs) and 2 research institutes. The objective of the project was to create an autonomous and automated domestic environment, primarily for elderly people and people with physical and motor disabilities. A known and familiar environment should help users in their daily activities and it should act as a virtual caregiver by calling, if necessary, relief efforts...
November 13, 2017: Sensors
https://www.readbyqxmd.com/read/29136241/wikipathways-a-multifaceted-pathway-database-bridging-metabolomics-to-other-omics-research
#5
Denise N Slenter, Martina Kutmon, Kristina Hanspers, Anders Riutta, Jacob Windsor, Nuno Nunes, Jonathan Mélius, Elisa Cirillo, Susan L Coort, Daniela Digles, Friederike Ehrhart, Pieter Giesbertz, Marianthi Kalafati, Marvin Martens, Ryan Miller, Kozo Nishida, Linda Rieswijk, Andra Waagmeester, Lars M T Eijssen, Chris T Evelo, Alexander R Pico, Egon L Willighagen
WikiPathways (wikipathways.org) captures the collective knowledge represented in biological pathways. By providing a database in a curated, machine readable way, omics data analysis and visualization is enabled. WikiPathways and other pathway databases are used to analyze experimental data by research groups in many fields. Due to the open and collaborative nature of the WikiPathways platform, our content keeps growing and is getting more accurate, making WikiPathways a reliable and rich pathway database. Previously, however, the focus was primarily on genes and proteins, leaving many metabolites with only limited annotation...
November 10, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29135451/software-design-and-implementation-concepts-for-an-interoperable-medical-communication-framework
#6
Andreas Besting, Sebastian Bürger, Martin Kasparick, Benjamin Strathen, Frank Portheine
The new IEEE 11073 service-oriented device connectivity (SDC) standard proposals for networked point-of-care and surgical devices constitutes the basis for improved interoperability due to its independence of vendors. To accelerate the distribution of the standard a reference implementation is indispensable. However, the implementation of such a framework has to overcome several non-trivial challenges. First, the high level of complexity of the underlying standard must be reflected in the software design. An efficient implementation has to consider the limited resources of the underlying hardware...
November 14, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/29133283/open-source-electronic-health-record-systems-for-low-resource-settings-systematic-review
#7
REVIEW
Assel Syzdykova, André Malta, Maria Zolfo, Ermias Diro, José Luis Oliveira
BACKGROUND: Despite the great impact of information and communication technologies on clinical practice and on the quality of health services, this trend has been almost exclusive to developed countries, whereas countries with poor resources suffer from many economic and social issues that have hindered the real benefits of electronic health (eHealth) tools. As a component of eHealth systems, electronic health records (EHRs) play a fundamental role in patient management and effective medical care services...
November 13, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29132635/need-of-informatics-in-designing-interoperable-clinical-registries
#8
Majid Rastegar-Mojarad, Sunghwan Sohn, Liwei Wang, Feichen Shen, Troy C Bleeker, William A Cliby, Hongfang Liu
Clinical registries are designed to collect information relating to a particular condition for research or quality improvement. Intuitively, informatics in the area of data management and extraction plays a central role in clinical registries. Due to various reasons such as lack of informatics awareness or expertise, there may be little informatics involvement in designing clinical registries. In this paper, we studied a clinical registry from two critical perspectives, data quality and interoperability, where informatics can play a role...
December 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29132625/variation-in-interoperability-across-clinical-laboratories-nationwide
#9
Vaishali Patel, Lauren McNamara, Prashila Dullabh, Megan E Sawchuk, Matthew Swain
OBJECTIVE: To characterize nationwide variation and factors associated with clinical laboratories': (1) capabilities to send structured test results electronically to ordering practitioners' EHR systems; and (2) their levels of exchange activity, as measured by whether they sent more than three-quarters of their test results as structured data to ordering practitioners' EHR systems. MATERIALS AND METHODS: A national survey of all independent and hospital laboratories was conducted in 2013...
December 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29121852/an-informatics-approach-to-interprofessional-management-of-low-back-pain-a-feasibility-study-using-the-omaha-system
#10
Robin R Austin, Karen A Monsen, Craig Schulz
BACKGROUND: Low back pain (LBP) is a complex health care issue that often involves multiple providers across various care settings. Health information technology (HIT) holds promise to improve care delivery by providing infrastructure for communication, clinical documentation, and management of patient data. Standardized terminology is essential for interoperability and enables evaluation of clinical data generated by documentation in an electronic health record (EHR). OBJECTIVE: The purpose of this study was to demonstrate the feasibility of mapping evidence-based practice for conservative management of low back pain to the Omaha System and foster inter-professional communication and collaboration among diverse practitioners and patients...
October 6, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/29113528/capturing-health-literacy-assessment-in-the-electronic-health-record-through-evidence-based-concept-creation-a-review-of-the-literature-and-recommendations-for-action
#11
Ruth E Wetta, Roberta D Severin, Heidi Gruhler, Nate Lewis
Health literacy is the capacity to understand and act upon health-related information and navigate the healthcare system. Published evidence demonstrates a relationship between health literacy and health status. Because of this, there are increasingly calls for a health literacy assessment to be collected and stored in the electronic health record for use by the healthcare team. This article describes the results of a literature review of health literacy assessment instruments with the goal of formulating semantically interoperable concepts that may be used to store the interpretation of the health literacy assessment in the electronic health record...
November 1, 2017: Health Informatics Journal
https://www.readbyqxmd.com/read/29112537/infusion-pump-interoperability-high-reliability-and-safety-concerns-lead-to-unintended-consequences
#12
Lola Rust, Mary Beth Mitchell
No abstract text is available yet for this article.
November 2017: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/29099412/dual-time-point-quantitative-spect-ct-parathyroid-imaging-using-a-single-computed-tomography-feasibility-and-operator-variability
#13
Simin Razavi, Blair Ziebarth, Ran Klein, Wanzhen Zeng
OBJECTIVES: Dual-phase parathyroid scan with Tc-sestamibi is a standardized imaging method for diagnosing parathyroid adenoma and hyperplasia. Conventional planar images using a gamma camera are performed routinely in early and delayed time points, followed by a single SPECT-CT. SPECT-CT on both early and delayed time points, although clinically useful, is not commonly performed to avoid extra radiation exposure from computed tomography (CT). This study explores the feasibility of co-registering early and delayed SPECT-CT from a single CT and evaluates the most effective combination of images for co-registration...
November 2, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29092948/dcmqi-an-open-source-library-for-standardized-communication-of-quantitative-image-analysis-results-using-dicom
#14
Christian Herz, Jean-Christophe Fillion-Robin, Michael Onken, Jörg Riesmeier, Andras Lasso, Csaba Pinter, Gabor Fichtinger, Steve Pieper, David Clunie, Ron Kikinis, Andriy Fedorov
Quantitative analysis of clinical image data is an active area of research that holds promise for precision medicine, early assessment of treatment response, and objective characterization of the disease. Interoperability, data sharing, and the ability to mine the resulting data are of increasing importance, given the explosive growth in the number of quantitative analysis methods being proposed. The Digital Imaging and Communications in Medicine (DICOM) standard is widely adopted for image and metadata in radiology...
November 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/29092930/developing-cancer-informatics-applications-and-tools-using-the-nci-genomic-data-commons-api
#15
Shane Wilson, Michael Fitzsimons, Martin Ferguson, Allison Heath, Mark Jensen, Josh Miller, Mark W Murphy, James Porter, Himanso Sahni, Louis Staudt, Yajing Tang, Zhining Wang, Christine Yu, Junjun Zhang, Vincent Ferretti, Robert L Grossman
The NCI Genomic Data Commons (GDC) was launched in 2016 and makes available over 4 petabytes (PB) of cancer genomic and associated clinical data to the research community. This dataset continues to grow and currently includes over 14,500 patients. The GDC is an example of a biomedical data commons, which collocates biomedical data with storage and computing infrastructure and commonly used web services, software applications, and tools to create a secure, interoperable, and extensible resource for researchers...
November 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/29091924/the-aerodynamics-of-flight-in-an-insect-flight-mill
#16
Gal Ribak, Shay Barkan, Victoria Soroker
Predicting the dispersal of pest insects is important for pest management schemes. Flight-mills provide a simple way to evaluate the flight potential of insects, but there are several complications in relating tethered-flight to natural flight. We used high-speed video to evaluate the effect of flight-mill design on flight of the red palm weevil (Rynchophorous ferruginneus) in four variants of a flight-mill. Two variants had the rotating radial arm pivoted on the main shaft of the rotation axis, allowing freedom to elevate the arm as the insect applied lift force...
2017: PloS One
https://www.readbyqxmd.com/read/29081012/combining-ontologies-and-open-standards-to-derive-a-middle-layer-information-model-for-interoperability-of-personal-and-electronic-health-records
#17
Panagiotis Plastiras, Dympna M O'Sullivan
The aim of our study was to enable better interoperability between Personal Health Record (PHR) and Electronic Health Record (EHR) systems and vice versa. A multi-layer architectural model that resides between a PHR and EHR system has been developed. The model consists of an ontology-driven information model and a set of transformation rules that work in conjunction to process data exported from a PHR or EHR system and prepare it accordingly for the receiving system. The model was evaluated by executing a set of case study scenarios containing data from both a PHR and an EHR system...
October 28, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29072985/electronic-information-standards-to-support-obesity-prevention-and-bridge-services-across-systems-2010-2015
#18
Jennifer L Wiltz, Heidi M Blanck, Brian Lee, S Lawrence Kocot, Laura Seeff, Lisa C McGuire, Janet Collins
Electronic information technology standards facilitate high-quality, uniform collection of data for improved delivery and measurement of health care services. Electronic information standards also aid information exchange between secure systems that link health care and public health for better coordination of patient care and better-informed population health improvement activities. We developed international data standards for healthy weight that provide common definitions for electronic information technology...
October 26, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29072831/a-soa-based-platform-to-support-clinical-data-sharing
#19
R Gazzarata, B Giannini, M Giacomini
The eSource Data Interchange Group, part of the Clinical Data Interchange Standards Consortium, proposed five scenarios to guide stakeholders in the development of solutions for the capture of eSource data. The fifth scenario was subdivided into four tiers to adapt the functionality of electronic health records to support clinical research. In order to develop a system belonging to the “Interoperable” Tier, the authors decided to adopt the service-oriented architecture paradigm to support technical interoperability, Health Level Seven Version 3 messages combined with LOINC (Logical Observation Identifiers Names and Codes) vocabulary to ensure semantic interoperability, and Healthcare Services Specification Project standards to provide process interoperability...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29069517/expanded-and-updated-data-and-a-query-pipeline-for-ibeetle-base
#20
Jürgen Dönitz, Lizzy Gerischer, Stefan Hahnke, Stefan Pfeiffer, Gregor Bucher
The iBeetle-Base provides access to sequence and phenotype information for genes of the beetle Tribolium castaneum. It has been updated including more and updated data and new functions. RNAi phenotypes are now available for >50% of the genes, which represents an expansion of 60% compared to the previous version. Gene sequence information has been updated based on the new official gene set OGS3 and covers all genes. Interoperability with FlyBase has been enhanced: First, gene information pages of homologous genes are interlinked between both databases...
October 24, 2017: Nucleic Acids Research
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