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JOURNAL ARTICLE
Zejia Wu, Songyuan Luo, Dongqin Cai, Wenhui Lin, Xiaolu Hu, Ting Zhou, Xuxing Zhang, Yingqing Feng, Jianfang Luo
AIM: To investigate the causal relationship between metabolic syndrome (MetS) and its components and 14 cardiovascular diseases using Mendelian randomization (MR). METHODS: We used summary statistics from large-scale genome-wide association studies of MetS, its components, and cardiovascular diseases. We performed a two-sample MR analysis using the inverse-variance weighted method and other sensitivity methods. We also performed multivariate MR to adjust for potential risk factors...
April 20, 2024: Diabetes Research and Clinical Practice
#22
JOURNAL ARTICLE
Morgan Clennin, Liza Reifler, Olivia Goodman, Meagan C Brown, Suma Vupputuri, Stacie L Daugherty, Mario Schootman
INTRODUCTION: Obesity affects four in ten US adults. One of the most prevalent health-related social risk factors in the US is housing instability, which is also associated with cardiovascular health outcomes, including obesity. The objective of this research brief is to examine the association between housing instability with obesity status among a representative sample of insured adults across seven integrated health systems. METHODS: Kaiser Permanente National Social Needs Survey used a multistage stratified sampling framework to administer a cross-sectional survey across seven integrated health systems (administered Jan...
April 20, 2024: American Journal of Preventive Medicine
#23
JOURNAL ARTICLE
Robert H Fitts, Xinrui Wang, Wai-Meng Kwok, Amadou K S Camara
Cardiovascular disease is a leading cause of morbidity and mortality, and exercise-training (TRN) is known to reduce risk factors and protect the heart from ischemia and reperfusion injury. Though the cardioprotective effects of exercise are well-documented, underlying mechanisms are not well understood. This review highlights recent findings and focuses on cardiac factors with emphasis on K+ channel control of the action potential duration (APD), β-adrenergic and adenosine regulation of cardiomyocyte function, and mitochondrial Ca2+ regulation...
April 22, 2024: International Journal of Sports Medicine
#24
JOURNAL ARTICLE
Jingyi Tong, Tingting Ji, Nan Liu, Yibin Chen, Zongjun Li, Xuejuan Lin, Yi Xing, Qifu Li
OBJECTIVE: Acute ischemic stroke (AIS) stands as a leading cause of death and disability globally. This study aimed to investigate the risk factors linked with AIS in patients undergoing maintenance hemodialysis (MHD) and to create and validate nomogram models. METHODS: We examined the medical records of 314 patients with stage 5 chronic kidney disease (CKD5) undergoing MHD, who sought neurology outpatient department consultation for suspected AIS symptoms between January 2018 and December 2023...
April 22, 2024: Cerebrovascular Diseases Extra
#25
JOURNAL ARTICLE
David Trujillo-Flores, José de J García-Mendoza
One of the complications during an acute coronary syndrome event is the presence of arrhythmias. Among them, those of the supraventricular type, especially atrial fibrillation, carry a poor prognosis both in the short and long term, being the cause of situations such as cerebrovascular event, ventricular arrhythmias, and increased mortality. The arrhythmia tends to appear in a certain population group with particular risk factors during the index event in approximately 10% of cases. Appropriate treatment at the time of its onset, thanks to the use of drugs that modulate heart rate, rhythm, and anticoagulant management in the most vulnerable groups, will lead to a less bleak outcome for these patients...
2024: Archivos de Cardiología de México
#26
JOURNAL ARTICLE
Yaguang Wei, Heresh Amini, Xinye Qiu, Edgar Castro, Tingfan Jin, Kanhua Yin, Bryan N Vu, James Healy, Yijing Feng, Jiangshan Zhang, Brent Coull, Joel Schwartz
BACKGROUND: Air pollution is a recognized risk factor for cardiovascular disease (CVD). Temperature is also linked to CVD, with a primary focus on acute effects. Despite the close relationship between air pollution and temperature, their health effects are often examined separately, potentially overlooking their synergistic effects. Moreover, fewer studies have performed mixture analysis for multiple co-exposures, essential for adjusting confounding effects among them and assessing both cumulative and individual effects...
April 18, 2024: Environment International
#27
JOURNAL ARTICLE
Abel A Pavía-López, José A Magaña-Serrano, José A Cigarroa-López, Adolfo Chávez-Mendoza, José L Mayorga-Butrón, Diego Araiza-Garaygordobil, Juan B Ivey-Miranda, Gustavo F Méndez-Machado, Héctor González-Godínez, Luisa F Aguilera-Mora, Antonio Jordán-Ríos, Luis Olmos-Domínguez, Marcos J Olalde-Román, Emma M Miranda-Malpica, Zuilma Vázquez-Ortiz, Jorge Rayo-Chávez, Alexandra A Mendoza, Manlio F Márquez-Murillo, Sergio A Chávez-Leal, Amada Álvarez-San Gabriel, Marissa A Silva-García, Alex D Pacheco-Bouthiller, Jorge A Aldrete-Velazco, Carlos A Guizar-Sánchez, Efraín Gaxiola-López, Arturo Guerra-López, Lourdes Figueiras-Graillet, Gustavo Sánchez-Miranda, Genaro H Mendoza-Zavala, Moisés Aceves-García, Adolfo Chávez-Negrete, Marisol Arroyo-Hernández, Bertha B Montaño-Velázquez, Luis F Romero-Moreno, María M Baquero-Hoyos, Liliana Velasco-Hidalgo, Ana L Rodríguez-Lozano, Nancy E Aguilar-Gómez, Mario Rodríguez-Vega, Jorge E Cossío-Aranda
Chronic heart failure continues to be one of the main causes of impairment in the functioning and quality of life of people who suffer from it, as well as one of the main causes of mortality in our country and around the world. Mexico has a high prevalence of risk factors for developing heart failure, such as high blood pressure, diabetes, and obesity, which makes it essential to have an evidence-based document that provides recommendations to health professionals involved in the diagnosis and treatment of these patients...
2024: Archivos de Cardiología de México
#28
JOURNAL ARTICLE
Nawar Shara, Roxanne Mirabal-Beltran, Bethany Talmadge, Noor Falah, Maryam Ahmad, Ramon Dempers, Samantha Crovatt, Steven Eisenberg, Kelley Anderson
BACKGROUND: Cardiovascular conditions (eg, cardiac and coronary conditions, hypertensive disorders of pregnancy, and cardiomyopathies) were the leading cause of maternal mortality between 2017 and 2019. The United States has the highest maternal mortality rate of any high-income nation, disproportionately impacting those who identify as non-Hispanic Black or Hispanic. Novel clinical approaches to the detection and diagnosis of cardiovascular conditions are therefore imperative. Emerging research is demonstrating that machine learning (ML) is a promising tool for detecting patients at increased risk for hypertensive disorders during pregnancy...
April 22, 2024: JMIR Cardio
#29
JOURNAL ARTICLE
María Ángeles Bernal-Jiménez, German Calle, Alejandro Gutiérrez Barrios, Livia Luciana Gheorghe, Celia Cruz-Cobo, Nuria Trujillo-Garrido, Amelia Rodríguez-Martín, Josep A Tur, Rafael Vázquez-García, María José Santi-Cano
BACKGROUND: Coronary heart disease is one of the leading causes of mortality worldwide. Secondary prevention is essential, as it reduces the risk of further coronary events. Mobile health (mHealth) technology could become a useful tool to improve lifestyles. OBJECTIVE: This study aimed to evaluate the effect of an mHealth intervention on people with coronary heart disease who received percutaneous coronary intervention. Improvements in lifestyle regarding diet, physical activity, and smoking; level of knowledge of a healthy lifestyle and the control of cardiovascular risk factors (CVRFs); and therapeutic adherence and quality of life were analyzed...
April 22, 2024: JMIR MHealth and UHealth
#30
JOURNAL ARTICLE
Oscar H Del Brutto, Robertino M Mera, Denisse A Rumbea, Emilio E Arias, Eduardo J Guzmán, Mark J Sedler
UNLABELLED: Reports addressing the effects of oily fish intake on bone health are inconsistent. This study shows that consumption of ≥ 5.2 oily fish servings/week (728 g) is associated with lower prevalence of osteopenia/osteoporosis in elderly women of Amerindian ancestry. Results suggest a beneficial effect of oily fish intake in this population. OBJECTIVES: Oily fish is a major dietary source of omega-3 polyunsaturated fatty acids and other nutrients that may have a positive effect on bone health...
April 22, 2024: Archives of Osteoporosis
#31
JOURNAL ARTICLE
Ashly C Westrick, Peiyao Zhu, Christopher R Friese, Kenneth M Langa, Lindsay C Kobayashi
PURPOSE: Cardiovascular risk factors (CVRFs) are associated with increased risk for cognitive impairment and decline in the general population, but less is known about how CVRFs might influence cognitive aging among older cancer survivors. We aimed to determine how CVRFs prior to a cancer diagnosis affect post-cancer diagnosis memory aging, compared to cancer-free adults, and by race/ethnicity. METHODS: Incident cancer diagnoses and memory (immediate and delayed recall) were assessed biennially in the US Health and Retirement Study (N = 5,736, 1998-2018)...
April 22, 2024: Journal of Cancer Survivorship: Research and Practice
#32
JOURNAL ARTICLE
Jekaterina Aid, Ajime Tom Tanjeko, Jef Serré, Moritz Eggelbusch, Wendy Noort, Gerard M J de Wit, Michel van Weeghel, Marju Puurand, Kersti Tepp, Ghislaine Gayan-Ramirez, Hans Degens, Tuuli Käämbre, Rob C I Wüst
AIMS: Active cigarette smoking is a major risk factor for chronic obstructive pulmonary disease that remains elevated after cessation. Skeletal muscle dysfunction has been well documented after smoking, but little is known about cardiac adaptations to cigarette smoking. The underlying cellular and molecular cardiac adaptations, independent of confounding lifestyle factors, and time course of reversibility by smoking cessation remain unclear. We hypothesized that smoking negatively affects cardiac metabolism and induces local inflammation in mice, which do not readily reverse upon 2-week smoking cessation...
April 22, 2024: Acta Physiologica
#33
JOURNAL ARTICLE
Ziqi Ni, Jiaqi Cao, Meiling Shan, Yanyan Zhang, Lijun Shi
The developmental origins of health and disease concept highlights the impact of early environments on chronic non-communicable diseases like diabetes, cardiovascular disease, and cancer. Studies using animal models have investigated how maternal factors such as undernutrition, overnutrition, obesity, and exposure to chemicals or hypoxia affect fetal development and offspring health, leading to issues like low birth weight, high blood pressure, dyslipidemia, and insulin resistance. Given the increasing prevalence of overweight and obesity among reproductive-age women, effective interventions are critical...
April 5, 2024: Journal of Visualized Experiments: JoVE
#34
JOURNAL ARTICLE
Aditya Bhonsale, Jianhui Zhu, Floyd Thoma, Steve Koscumb, Krishna Kancharla, Andrew Voigt, Jared Magnani, N A Estes, Samir Saba, Oscar Marroquin, Suresh Mulukutla, Sandeep Jain
BACKGROUND: The risk factor (RF) burden, clinical course, and long-term outcome among patients with atrial fibrillation (AF) aged <65 years is unclear. METHODS: Adult (n=67 221; mean age, 72.4±12.3 years; and 45% female) patients with AF evaluated at the University of Pittsburgh Medical Center between January 2010 and December 2019 were studied. Hospital system-wide electronic health records and administrative data were utilized to ascertain RFs, comorbidities, and subsequent hospitalization and cardiac interventions...
April 22, 2024: Circulation. Arrhythmia and Electrophysiology
#35
JOURNAL ARTICLE
James A Coleman, Ruben Doste, Zakariye Ashkir, Raffaele Coppini, Rafael Sachetto, Hugh Watkins, Betty Raman, Alfonso Bueno-Orovio
AIMS: Lethal arrhythmias in hypertrophic cardiomyopathy (HCM) are widely attributed to myocardial ischaemia and fibrosis. How these factors modulate arrhythmic risk remains largely unknown, especially as invasive mapping protocols are not routinely used in these patients. By leveraging multiscale digital-twin technologies, we aim to investigate ischaemic mechanisms of increased arrhythmic risk in HCM. METHODS AND RESULTS: Computational models of human HCM cardiomyocytes, tissue and ventricles were used to simulate outcomes of phase 1A acute myocardial ischaemia...
April 22, 2024: Cardiovascular Research
#36
JOURNAL ARTICLE
Janhavi Mallaiah, Olajide Williams, John P Allegrante
Community health workers (CHWs) are increasingly being required to perform complex health care activities, especially in community cardiovascular disease and stroke prevention. However, currently, there are no psychometrically validated instruments for assessing CHW competencies in these roles. This article describes the development and validation of the stroke literacy assessment test (SLAT)-pertaining to the Life's Simple Seven (LS7) risk factors for stroke-for evaluating CHWs' competencies in the context of education and training programs...
April 22, 2024: Health Education & Behavior
#37
JOURNAL ARTICLE
Wongsakorn Luangphiphat, Pinidphon Prombutara, Viroj Muangsillapasart, Damrong Sukitpunyaroj, Eric Eeckhout, Malai Taweechotipatr
Chronic coronary syndrome (CCS) has a high mortality rate, and dyslipidemia is a major risk factor. Atherosclerosis, a cause of CCS, is influenced by gut microbiota dysbiosis and its metabolites. The objective of this study was to study the diversity and composition of gut microbiota and related clinical parameters among CCS patients undergoing coronary angiography and dyslipidemia patients in comparison to healthy volunteers in Thailand. CCS patients had more risk factors and higher inflammatory markers, high-sensitivity C-reactive protein (hs-CRP) than others...
2024: Frontiers in Microbiology
#38
JOURNAL ARTICLE
Salim Benkhedda, Nacera Bengherbi, Yahia Cherifi, Souhila Ouabdesselam, Nabila Waheed, Clara M Harris
Background Chemotherapy correlates to acute and long-term cardiotoxicity, is reflected clinically by myocardial and vascular endothelial dysfunction, and can cause cardiovascular complications. Thus, early diagnosis of cardiovascular disease in cancer patients undergoing anti-cancer treatment is necessary to enhance long-term survival. Our principal objective in this study was to discern the impact of specific anti-cancer chemotherapeutics and biologics on arterial stiffness alterations before and after the administration...
March 2024: Curēus
#39
REVIEW
Yazan Almohtasib, Andrew J Fancher, Khalid Sawalha
Over the past two decades, research efforts into cardiovascular disease (CVD) have uncovered findings that fundamentally challenge our understanding of CVD, particularly atherosclerosis. Atherosclerosis was primarily attributed to the well-described abnormal lipid accumulation theory, involving plaque growth with subsequent plaque hemorrhage resulting in acute vessel thrombosis that may or may not rupture. This perspective has now evolved to encompass more complex pathways, wherein the accumulation of abnormal products of oxidation and inflammation is the most likely factor mediating atherosclerotic plaque growth...
March 2024: Curēus
#40
JOURNAL ARTICLE
Joo Hee Jeong, Kwang-Sig Lee, Seong-Mi Park, So Ree Kim, Mi-Na Kim, Shung Chull Chae, Seung-Ho Hur, In Whan Seong, Seok Kyu Oh, Tae Hoon Ahn, Myung Ho Jeong
Several regression-based models for predicting outcomes after acute myocardial infarction (AMI) have been developed. However, prediction models that encompass diverse patient-related factors over time are limited. This study aimed to develop a machine learning-based model to predict longitudinal outcomes after AMI. This study was based on a nationwide prospective registry of AMI in Korea ( n = 13,104). Seventy-seven predictor candidates from prehospitalization to 1 year of follow-up were included, and six machine learning approaches were analyzed...
2024: Frontiers in Cardiovascular Medicine
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