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Cardiovascular risk factor

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https://www.readbyqxmd.com/read/28743129/fibroblast-growth-factor-23-predicts-mortality-and-end-stage-renal-disease-in-a-canadian-asian-population-with-chronic-kidney-disease
#1
Ishwarlal Jialal, Fernando Camacho, Bharat Nathoo, Paul Tam, Roma Pahwa, George G Wu
BACKGROUND: Chronic kidney disease (CKD) is a leading cause of morbidity and mortality. Biomarkers that predict end-stage renal disease (ESRD) and/or mortality could usher in new therapeutics to halt this onslaught. While fibroblast growth factor (FGF)23 can predict both ESRD and mortality, it has not been studied in North American CKD patients of Asian ethnicity. METHOD: This is a prospective investigation about the role of FGF23 in 998 Canadian patients of Asian descent with CKD defined by an estimated glomerular filtration rate (eGFR) <60 mL/min/m2 and followed up for 3 years...
July 26, 2017: Nephron
https://www.readbyqxmd.com/read/28742646/comparison-of-3-symptom-classification-methods-to-standardize-the-history-component-of-the-heart-score
#2
Michael R Marchick, Michael L Setteducato, Jesse J Revenis, Matthew A Robinson, Emily C Weeks, Thomas F Payton, David E Winchester, Brandon R Allen
OBJECTIVES: The History, Electrocardiography, Age, Risk factors, Troponin (HEART) score enables rapid risk stratification of emergency department patients presenting with chest pain. However, the subjectivity in scoring introduced by the history component has been criticized by some clinicians. We examined the association of 3 objective scoring models with the results of noninvasive cardiac testing. METHODS: Medical records for all patients evaluated in the chest pain center of an academic medical center during a 1-year period were reviewed retrospectively...
September 2017: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/28742334/health-effects-of-dietary-oxidized-tyrosine-and-dityrosine-administration-in-mice-with-nutrimetabolomic-strategies
#3
Yuhui Yang, Hui Zhang, Biao Yan, Tianyu Zhang, Ying Gao, Yonghui Shi, Guowei Le
This study aims to investigate the health effects of long-term dietary oxidized tyrosine (O-Tyr) and its main product (dityrosine) administration on mice metabolism. Mice received daily intragastric administration of either O-Tyr (320 μg/kg body weight), dityrosine (Dityr, 320 μg/kg body weight) or saline for consecutive six weeks. Urine and plasma samples were analyzed by NMR-based metabolomics strategies. Body weight, clinical chemistry, oxidative damage indexes and histopathological data were obtained as complementary information...
July 25, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28742027/a-regularized-deep-learning-approach-for-clinical-risk-prediction-of-acute-coronary-syndrome-using-electronic-health-records
#4
Zhengxing Huang, Wei Dong, Huilong Duan, Jiquan Liu
OBJECTIVE: Acute coronary syndrome (ACS), as a common and severe cardiovascular disease, is a leading cause of death and the principal cause of serious long-term disability globally. Clinical risk prediction of ACS is important for early intervention and treatment. Existing ACS risk scoring models are based mainly on a small set of hand-picked risk factors and often dichotomize predictive variables to simplify the score calculation [1-3]. METHODS: This study develops a regularized stacked denoising auto-encoder (SDAE) model to stratify clinical risks of ACS patients from a large volume of electronic health records (EHR)...
July 24, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28741279/identification-of-lead-molecules-in-garcinia-mangostana-l-against-pancreatic-cholesterol-esterase-activity-an-in-silico-approach
#5
George Kadakasseril Varghese, Rini Abraham, Nisha N Chandran, Solomon Habtemariam
Hypercholesterolemia is one of the major risk factors for the development and progression of atherosclerosis. Hence, inhibitors of cholesterol absorption have been investigated for decades as a strategy to prevent and treat cardiovascular diseases associated with hypercholesterolemia. Cholesterol esterase (CEase) in pancreatic juice plays a vital role in the hydrolysis of dietary cholesterol esters to cholesterol and fatty acids. Since inhibition of CEase might lead to a reduction of cholesterol absorption, an attempt is made in this study to identify lead molecules of Garcinia mangostana by the in silico approach...
July 24, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/28741263/unmet-needs-in-the-pathogenesis-and-treatment-of-cardiovascular-comorbidities-in-chronic-inflammatory-diseases
#6
REVIEW
Cristina Panico, Gianluigi Condorelli
The developments that have taken place in recent decades in the diagnosis and therapy of a number of diseases have led to improvements in prognosis and life expectancy. As a consequence, there has been an increase in the number of patients affected by chronic diseases and who can face new pathologies during their lifetime. The prevalence of chronic heart failure, for example, is approximately 1-2% of the adult population in developed countries, rising to ≥10% among people >70 years of age; in 2015, more than 85 million people in Europe were living with some sort of cardiovascular disease (CVD) (Lubrano and Balzan World J Exp Med 5:21-32, 5; Takahashi et al...
July 24, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28740629/comparison-of-coronary-artery-disease-guidelines-with-extracted-knowledge-from-data-mining
#7
Peyman Rezaei-Hachesu, Azadeh Oliyaee, Naser Safaie, Reza Ferdousi
Introduction: Coronary artery disease (CAD) is one of the major causes of disability and death in the world. Accordingly utilizing from a national and update guideline in heart-related disease are essential. Finding interesting rules from CAD data and comparison with guidelines was the objectives of this study. Methods: In this study 1993 valid and completed records related to patients (from 2009 to 2014) who had suffered from CAD were recruited and analyzed. Total of 25 variable including a target variable (CAD) and 24 inputs or predictor variables were used for knowledge discovery...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/28740627/correlation-between-severity-of-ultrasonographic-nonalcoholic-fatty-liver-disease-and-cardiometabolic-risk-among-filipino-wellness-patients
#8
Lucky R Cuenza, Tamara Louise J Razon, Juan Carlo Dayrit
Introduction: Nonalcoholic fatty liver disease (NAFLD) is a prevalent condition which is known to be related to factors that predispose to the development of coronary artery disease as well as development of metabolic syndrome. The study aimed to determine the association between ultrasound-based grading of hepatic steatosis with metabolic profile and estimated cardiovascular risk using the Framingham Risk Score (FRS). Methods: This was a cross-sectional study on 100 Filipino patients without established cardiovascular disease who underwent a general wellness health evaluation...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/28740585/testosterone-and-the-heart
#9
Travis Goodale, Archana Sadhu, Steven Petak, Richard Robbins
Testosterone (T) has a number of important effects on the cardiovascular system. In men, T levels begin to decrease after age 40, and this decrease has been associated with an increase in all-cause mortality and cardiovascular (CV) risk. Low T levels in men may increase their risk of developing coronary artery disease (CAD), metabolic syndrome, and type 2 diabetes. Reduced T levels in men with congestive heart failure (CHF) portends a poor prognosis and is associated with increased mortality. Studies have reported a reduced CV risk with higher endogenous T concentration, improvement of known CV risk factors with T therapy, and reduced mortality in T-deficient men who underwent T replacement therapy versus untreated men...
April 2017: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/28740584/cardiovascular-disease-in-acromegaly
#10
Morali D Sharma, Anh V Nguyen, Spandana Brown, Richard J Robbins
In patients with acromegaly, chronic excess of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) leads to the development of acromegalic cardiomyopathy. Its main features are biventricular hypertrophy, diastolic dysfunction, and in later stages, systolic dysfunction and congestive heart failure. Surgical and/or pharmacological treatment of acromegaly and control of cardiovascular risk factors help reverse some of these pathophysiologic changes and decrease the high risk of cardiovascular complications...
April 2017: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/28740581/the-parathyroid-gland-and-heart-disease
#11
Spandana J Brown, Mary D Ruppe, Laila S Tabatabai
The parathyroid glands are critical to maintaining calcium homeostasis through actions of parathyroid hormone (PTH). Recent clinical and molecular research has shown that direct and indirect actions of PTH also affect the heart and vasculature through downstream actions of G protein-coupled receptors in the myocardium and endothelial cells. Patients with disorders of the parathyroid gland have higher incidences of hypertension, arrhythmias, left ventricular hypertrophy, heart failure, and calcific disease which translate into increased cardiac morbidity and mortality...
April 2017: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/28740456/carotid-artery-stiffness-digital-endothelial-function-and-coronary-calcium-in-patients-with-essential-thrombocytosis-free-of-overt-atherosclerotic-disease
#12
Matjaz Vrtovec, Ajda Anzic, Irena Preloznik Zupan, Katja Zaletel, Ales Blinc
BACKGROUND: Patients with myeloproliferative neoplasms (MPNs) are at increased risk for atherothrombotic events. Our aim was to determine if patients with essential thrombocytosis (ET), a subtype of MPNs, free of symptomatic atherosclerosis, have greater carotid artery stiffness, worse endothelial function, greater coronary calcium and carotid plaque burden than control subjects. PATIENTS AND METHODS: 40 ET patients without overt vascular disease, and 42 apparently healthy, age and sex-matched control subjects with comparable classical risk factors for atherosclerosis and Framingham risk of coronary disease were enrolled...
June 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28739653/the-metabolic-syndrome-in-children-and-adolescents-shifting-the-focus-to-cardiometabolic-risk-factor-clustering
#13
Sheela N Magge, Elizabeth Goodman, Sarah C Armstrong
Metabolic syndrome (MetS) was developed by the National Cholesterol Education Program Adult Treatment Panel III, identifying adults with at least 3 of 5 cardiometabolic risk factors (hyperglycemia, increased central adiposity, elevated triglycerides, decreased high-density lipoprotein cholesterol, and elevated blood pressure) who are at increased risk of diabetes and cardiovascular disease. The constellation of MetS component risk factors has a shared pathophysiology and many common treatment approaches grounded in lifestyle modification...
July 24, 2017: Pediatrics
https://www.readbyqxmd.com/read/28739253/key-differences-between-apoc-iii-regulation-and-expression-in-intestine-and-liver
#14
Gabrielle West, Cayla Rodia, Diana Li, Zania Johnson, Hongli Dong, Alison B Kohan
ApoC-III is a critical cardiovascular risk factor, and humans expressing null mutations in apoC-III are robustly protected from cardiovascular disease. Because of its critical role in elevating plasma lipids and CVD risk, hepatic apoC-III regulation has been studied at length. Considerably less is known about the factors that regulate intestinal apoC-III. In this work, we use primary murine enteroids, Caco-2 cells, and dietary studies in wild-type mice to show that intestinal apoC-III expression does not change in response to fatty acids, glucose, or insulin administration, in contrast to hepatic apoC-III...
July 21, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28739184/carotid-plaque-instability-is-not-related-to-quantity-but-to-elemental-composition-of-calcification
#15
S Bischetti, M Scimeca, E Bonanno, M Federici, L Anemona, R Menghini, S Casella, M Cardellini, A Ippoliti, A Mauriello
BACKGROUND AND AIMS: Recent studies highlighted the role of calcification processes in the clinical progression of chronic cardiovascular diseases. In this study we investigated the relationship between the chemical composition of calcification and atherosclerotic plaque stability in carotid arteries. METHODS AND RESULTS: To this end, we characterized the calcification on 229 carotid plaques, by morphology, immunohistochemistry, transmission electron microscopy and energy dispersive X-ray microanalysis...
May 31, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28739139/results-of-the-hemo-study-suggest-that-p-cresol-sulfate-and-indoxyl-sulfate-are-not-associated-with-cardiovascular-outcomes
#16
Tariq Shafi, Tammy L Sirich, Timothy W Meyer, Thomas H Hostetter, Natalie S Plummer, Seungyoung Hwang, Michal L Melamed, Tanushree Banerjee, Josef Coresh, Neil R Powe
Cardiovascular disease, the leading cause of mortality in hemodialysis patients, is not fully explained by traditional risk factors. To help define non-traditional risk factors, we determined the association of predialysis total p-cresol sulfate, indoxyl sulfate, phenylacetylglutamine, and hippurate with cardiac death, sudden cardiac death, and first cardiovascular event in the 1,273 participants of the HEMO Study. The results were adjusted for potential demographic, clinical, and laboratory confounders. The mean age of the patients was 58 years, 63% were Black and 42% were male...
July 21, 2017: Kidney International
https://www.readbyqxmd.com/read/28739036/meta-analysis-of-the-effect-of-obstructive-sleep-apnea-on-cardiovascular-events-after-percutaneous-coronary-intervention
#17
REVIEW
Yingke Zhao, Branda Yee-Man Yu, Yanfei Liu, Yue Liu
Increasing evidence proved that obstructive sleep apnea (OSA) is associated with a variety of diseases, especially cardiovascular diseases. This study systematically reviewed the existing publications to assess the influence of OSA on cardiovascular survival among patients who underwent percutaneous coronary intervention. Eleven eligible publications, including 3,008 participants, were finally evaluated. Eight studies conducted adjustment of risk ratio for potential cardiovascular risk factors, 5 studies defined OSA groups as AHI (apnea hypopnea index) ≥15/hour, whereas the remaining eligible studies used AHI ≥5/hour, AHI ≥10/hour, or AHI ≥30/hour as the criteria...
June 28, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28739035/relationship-between-birth-weight-and-the-double-product-in-childhood-adolescence-and-adulthood-from-the-bogalusa-heart-study
#18
Fu Wang, Yingxiao Hua, Paul K Whelton, Tao Zhang, Camilo Alonso Fernandez, Huijie Zhang, Lydia Bazzano, Jiang He, Wei Chen, Shengxu Li
Low birth weight is associated with cardiovascular disease and its risk factors, including heart rate and blood pressure. Therefore, we examined the hypothesis that birth weight is related to blood pressure-heart rate product (double product, DP), an index of oxygen consumption and workload of the heart, at different ages. Heart rate at rest, blood pressure at rest, and birth weight data were available in 2,340 children (4 to 11 years), 1,621 adolescents (12 to 19 years), and 2,315 adults (20 to 52 years) from the Bogalusa Heart Study (total n = 6,276)...
June 28, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28738956/upper-extremity-pulse-pressure-predicts-amputation-free-survival-after-lower-extremity-bypass
#19
Eric S Wise, Justine E Wergin, Eric H Mace, Justiss A Kallos, Whitney E Muhlestein, Nicholas J Shelburne, Kyle M Hocking, Colleen M Brophy, Raul J Guzman
Increased pulse pressure reflects pathologic arterial stiffening and predicts cardiovascular events and mortality. The effect of pulse pressure on outcomes in lower extremity bypass patients remains unknown. We thus investigated whether preoperative pulse pressure could predict amputation-free survival in patients undergoing lower extremity bypass for atherosclerotic occlusive disease. An institutional database identified 240 included patients undergoing lower extremity bypass from 2005 to 2014. Preoperative demographics, cardiovascular risk factors, operative factors, and systolic and diastolic blood pressures were recorded, and compared between patients with pulse pressures above and below 80 mm Hg...
July 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28738800/benchmarked-performance-charts-using-principal-components-analysis-to-improve-the-effectiveness-of-feedback-for-audit-data-in-hiv-care
#20
Skevi Michael, Mark Gompels, Caroline Sabin, Hilary Curtis, Margaret T May
BACKGROUND: Feedback tools for clinical audit data that compare site-specific results to average performance over all sites can be useful for quality improvement. Proposed tools should be simple and clearly benchmark the site's performance, so that a relevant action plan can be directly implemented to improve patient care services. We aimed to develop such a tool in order to feedback data to UK HIV clinics participating in the 2015 British HIV Association (BHIVA) audit assessing compliance with the 2011 guidelines for routine investigation and monitoring of adult HIV-1- infected individuals...
July 24, 2017: BMC Health Services Research
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