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https://www.readbyqxmd.com/read/28545279/-impact-of-gender-and-age-on-in-hospital-major-adverse-cardiovascular-and-cerebrovascular-events-of-patients-with-acute-st-segment-elevation-myocardial-infarction
#1
Q N Shen, D X Wang, H B Zhai, Z C Dong, J Liu, B Zhang
Objective: To investigate the impact of gender and age on in-hospital major adverse cardiovascular and cerebrovascular events of patients with acute ST-segment elevation myocardial infarction (STEMI). Methods: This is a retrospective single-center study. A total of consecutive 1 102 patients with acute STEMI admitted to our hospital from January 2001 to December 2010 were recruited and clinical data were analyzed. The primary end point was in-hospital death due to any cause, and the secondary end point was in-hospital composite end point including death, re-infarction and stroke...
April 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28544654/hypogonadism-in-testicular-cancer-patients-is-associated-with-risk-factors-of-cardiovascular-disease-and-the-metabolic-syndrome
#2
C Bogefors, S Isaksson, J Bobjer, M Kitlinski, I Leijonhufvud, K Link, A Giwercman
More than 95% of testicular cancer are cured but they are at increased long-term risk of cardiovascular disease. The risk of cardiovascular disease and treatment intensity was reported, but it is unknown whether this effect of cancer therapy is direct or indirect, mediated through androgen deficiency. Our aim was, therefore, to evaluate whether testicular cancer patients have increased the prevalence of risk factors of cardiovascular disease and if these risk factors are associated with hypogonadism and/or the cancer treatment given...
May 23, 2017: Andrology
https://www.readbyqxmd.com/read/28544636/visit-to-visit-systolic-blood-pressure-variability-predicts-treatment-related-adverse-event-of-hyponatremia-in-sprint
#3
Abhinav Goyal, Kenechukwu Mezue, Janani Rangaswami
Hypertension is a common condition and an important cardiovascular risk factor. SPRINT trial showed that the beneficial effects of targeting systolic blood pressure <120 mmHg were accompanied by more adverse events. De-identified SPRINT database was used for this analysis. All subjects in each group that achieved their respective target blood pressure (<120, intensive; <140, standard) were included. Only readings after reaching target blood pressure for the first time were included. Subjects that never reached target or had <2 readings upon reaching target were excluded...
May 25, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28544117/increased-expression-of-stim1-orai1-in-platelets-of-stroke-patients-predictive-of-poor-outcomes
#4
M Dong, N Zheng, L J Ren, H Zhou, J Liu
BACKGROUND AND PURPOSE: The platelet activation that is mediated by store-operated Ca(2+) entry via stromal interaction molecule (STIM1) and Orai1 Ca(2+) influx channels has been shown to play a key role in ischaemic stroke (IS). This study aimed to evaluate the impact of platelet STIM1/Orai1 protein expression on outcomes of IS. METHODS: A total of 160 patients with acute non-cardioembolic IS, among whom 45 patients had small-vessel diseases and 115 patients had large-vessel diseases, were evaluated...
May 23, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28544066/type-2-diabetes-and-glucose-intolerance-in-a-population-with-intellectual-disabilities-the-stop-diabetes-cross-sectional-screening-study
#5
A J Dunkley, F Tyrer, L J Gray, S Bhaumik, R Spong, Y Chudasama, S-A Cooper, S Ganghadaran, M Davies, K Khunti
BACKGROUND: Adults with intellectual disabilities (ID) may be at increased risk of developing type 2 diabetes and cardiovascular disease, due to lifestyle factors, medications and other diagnosed conditions. Currently, there is lack of evidence on prevalence and prevention in this population. The aim of this study was to conduct a diabetes screening programme to determine prevalence of previously undiagnosed type 2 diabetes and impaired glucose regulation in people with ID. METHODS: Screening was conducted in a variety of community settings in Leicestershire, UK...
May 21, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28544026/immobilization-and-high-platelet-count-are-associated-with-thromboembolic-complications-in-heparin-induced-thrombocytopenia
#6
Juliane Bolbrinker, Edeltraut Garbe, Antonios Douros, Matthias Huber, Elisabeth Bronder, Andreas Klimpel, Frank Andersohn, Oliver Meyer, Abdulgabar Salama, Reinhold Kreutz
PURPOSE: Immune-mediated heparin-induced thrombocytopenia (HIT type II, HIT) is a potentially serious adverse drug reaction characterized by an increased risk of venous and arterial thrombosis. This study aimed to identify risk factors associated with the development of these complications. METHODS: Our study cohort included patients with HIT assembled in our pharmacovigilance center by reports from 51 collaborating hospitals in Berlin, Germany. To identify risk factors for thromboembolic complications, patients with thromboembolic events (cases) were compared to those without thromboembolic events (controls) in a case-control design...
May 24, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28543703/self-rated-physical-fitness-and-estimated-maximal-oxygen-uptake-in-relation-to-all-cause-and-cause-specific-mortality
#7
Alina Solomon, Katja Borodulin, Tiia Ngandu, Miia Kivipelto, Tiina Laatikainen, Jenni Kulmala
This study investigated the longitudinal associations of self-rated physical fitness and estimated maximal oxygen uptake (VO2max) with all-cause and cause-specific mortality. A total of 59 741 participants in the Finnish National FINRISK Study Cohort had data on self-rated physical fitness and covariates. A subsample of 4 823 participants had estimated VO2max data. Follow-up ranged from 3 to 38 years. Associations of self-rated physical fitness and VO2max with mortality were analysed using multivariate Cox proportional hazard models...
May 24, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28543215/fib-4-stage-of-liver-fibrosis-predicts-incident-heart-failure-among-hiv-infected-and-uninfected-patients
#8
Kaku A So-Armah, Joseph K Lim, Vincent Lo Re, Janet P Tate, H Chang Chung-Chou, Adeel A Butt, Cynthia L Gibert, David Rimland, Vincent C Marconi, Matthew B Goetz, Maria C Rodriguez-Barradas, Michael E DeBakey, Matthew J Budoff, Hilary A Tindle, Jeffrey H Samet, Amy C Justice, Matthew S Freiberg
Liver fibrosis is common, particularly in human immunodeficiency virus infected (HIV+) people. HIV+ people have excess congestive heart failure (CHF) risk compared to uninfected people. It remains unknown if stage of liver fibrosis influences the CHF risk or if HIV or hepatitis C virus (HCV) infection modifies this association. Our objectives were to assess whether: 1) stage of liver fibrosis is independently associated with incident CHF; 2) the association between stage of liver fibrosis and incident CHF is modified by HIV/HCV status...
May 24, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28542743/neuroimaging-cardiovascular-physiology-and-functional-outcomes-in-infants-with-congenital-heart-disease
#9
REVIEW
Nathalie H P Claessens, Christopher J Kelly, Serena J Counsell, Manon J N L Benders
This review integrates data on brain dysmaturation and acquired brain injury using fetal and neonatal magnetic resonance imaging (MRI), including the contribution of cardiovascular physiology to differences in brain development, and the relationship between brain abnormalities and subsequent neurological impairments in infants with congenital heart disease (CHD). The antenatal and neonatal period are critical for optimal brain development; the developing brain is particularly vulnerable to haemodynamic disturbances during this time...
May 19, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28542531/new-diagnostic-index-for-sarcopenia-in-patients-with-cardiovascular-diseases
#10
Haruhito Harada, Hisashi Kai, Rei Shibata, Hiroshi Niiyama, Yasuhiro Nishiyama, Toyoaki Murohara, Noriko Yoshida, Atsushi Katoh, Hisao Ikeda
BACKGROUND: Sarcopenia is an aging and disease-related syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, with the risk of frailty and poor quality of life. Sarcopenia is diagnosed by a decrease in skeletal muscle index (SMI) and reduction of either handgrip strength or gait speed. However, measurement of SMI is difficult for general physicians because it requires special equipment for bioelectrical impedance assay or dual-energy X-ray absorptiometry...
2017: PloS One
https://www.readbyqxmd.com/read/28542516/evaluation-of-the-systemic-micro-and-macrovasculature-in-stable-angina-a-case-control-study
#11
Ulf Neisius, Erin Olson, Sabrina H Rossi, Hagar A Ibrahim, Gemma Currie, Anna F Dominiczak, Christian Delles
AIMS: The diagnosis of stable angina involves the use of probability estimates based on clinical presentation, age, gender and cardiovascular risk factors. In view of the link between the cardiac and systemic vasculature we tested whether non-invasive measures of systemic micro- and macrovascular structure and function differentiate between individuals with flow-limiting coronary artery disease (CAD) and those with normal coronary arteries (NCA). METHODS AND RESULTS: We recruited 84 patients undergoing elective coronary angiography for investigation of symptoms of stable angina...
2017: PloS One
https://www.readbyqxmd.com/read/28542510/associations-among-apolipoproteins-oxidized-high-density-lipoprotein-and-cardiovascular-events-in-patients-on-hemodialysis
#12
Hirokazu Honda, Tsutomu Hirano, Masashi Ueda, Shiho Kojima, Shinichi Mashiba, Yasuyuki Hayase, Tetsuo Michihata, Kanji Shishido, Keiko Takahashi, Nozomu Hosaka, Misa Ikeda, Daisuke Sanada, Takanori Shibata
Apolipoproteins are associated with survival among patients on hemodialysis (HD), but these associations might be influenced by dysfunctional (oxidized) high-density lipoprotein (HDL). We assessed associations among apolipoproteins and oxidized HDL, mortality and cardiovascular disease (CVD) events in patients on HD. This prospective observational study examined 412 patients on prevalent HD. Blood samples were obtained before dialysis at baseline to measure lipids, apolipoproteins, oxidized LDL, oxidized HDL, high-sensitivity C-reactive protein (hs-CRP) and interleukin (IL)-6 at baseline, and HDL-C and hs-CRP were measured 12 months later...
2017: PloS One
https://www.readbyqxmd.com/read/28542479/preliminary-study-of-hypoxia-related-cardiovascular-mediator-markers-in-patients-with-end-stage-renal-disease-with-and-without-diabetes-and-the-effects-of-haemodialysis
#13
A Treweeke, J Hall, S Lambie, S J Leslie, I L Megson, S M MacRury
BACKGROUND: Evidence points to activation of pro-inflammatory and pro-thrombotic stimuli during the haemodialysis process in end-stage renal disease (ESRD) with potential to predispose to cardiovascular events. Diabetes is associated with a higher incidence of cardiovascular disease in haemodialysis patients. We tested the hypothesis that a range of mediators and markers that modulate cardiovascular risk are elevated in haemodialysis patients with diabetes compared to those without. METHODS: Men and women with diabetes (n = 6) and without diabetes (n = 6) aged 18-90 years receiving haemodialysis were recruited...
2017: PloS One
https://www.readbyqxmd.com/read/28542419/in-vivo-oxidized-albumin-a-pro-inflammatory-agent-in-hypoalbuminemia
#14
Faiga Magzal, Shifra Sela, Andrea Szuchman-Sapir, Snait Tamir, Regina Michelis, Batya Kristal
Hypoalbuminemia of Hemodialysis (HD) patients is an independent cardiovascular risk factor, however, there is no mechanistic explanation between hypoalbuminemia and vascular injury. In the event of oxidative stress and inflammation to which HD patients are exposed, albumin is oxidized and undetected by common laboratory methods, rendering an apparent hypoalbuminemia. We wanted to show that these circulating modified oxidized albumin molecules cause direct vascular damage, mediating inflammation. Once these in-vivo albumin modifications were reduced in- vitro, the apparent hypoalbuminemia concomitantly with its inflammatory effects, were eliminated...
2017: PloS One
https://www.readbyqxmd.com/read/28542317/systematic-review-of-dietary-salt-reduction-policies-evidence-for-an-effectiveness-hierarchy
#15
Lirije Hyseni, Alex Elliot-Green, Ffion Lloyd-Williams, Chris Kypridemos, Martin O'Flaherty, Rory McGill, Lois Orton, Helen Bromley, Francesco P Cappuccio, Simon Capewell
BACKGROUND: Non-communicable disease (NCD) prevention strategies now prioritise four major risk factors: food, tobacco, alcohol and physical activity. Dietary salt intake remains much higher than recommended, increasing blood pressure, cardiovascular disease and stomach cancer. Substantial reductions in salt intake are therefore urgently needed. However, the debate continues about the most effective approaches. To inform future prevention programmes, we systematically reviewed the evidence on the effectiveness of possible salt reduction interventions...
2017: PloS One
https://www.readbyqxmd.com/read/28542113/increased-arterial-stiffness-in-nonalcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#16
Veeravich Jaruvongvanich, Jirat Chenbhanich, Anawin Sanguankeo, Pattara Rattanawong, Karn Wijarnpreecha, Sikarin Upala
BACKGROUND: Arterial function is a marker of early atherosclerotic changes and cardiovascular disease. Several studies have suggested the possible association between nonalcoholic fatty liver disease (NAFLD) and increased arterial stiffness. Thus, we conducted a systematic review and meta-analysis to better characterize this association. PATIENTS AND METHODS: A comprehensive search of the databases of the MEDLINE and EMBASE was carried out from inception through September 2016...
May 24, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28542008/radiation-risk-of-cardiovascular-diseases-in-the-cohort-of-russian-emergency-workers-of-the-chernobyl-accident
#17
V V Kashcheev, S Yu Chekin, S V Karpenko, M A Maksioutov, A N Menyaylo, K A Tumanov, E V Kochergina, P V Kashcheeva, A I Gorsky, N V Shchukina, S S Lovachev, O K Vlasov, V K Ivanov
This paper continues a series of publications that analyze the impact of radiation on incidence of circulatory system diseases in the cohort of Russian recovery operation workers (liquidators) and presents the results of the analysis of cardiovascular disease (CVD) incidence. The studied cohort consists of 53,772 liquidators who arrived in the Chernobyl accident zone within the first year after the accident (26 April 1986 to 26 April 1987). The individual doses varied from 0.0001 Gy to 1.42 Gy, and the mean external whole body dose in the cohort was 0...
July 2017: Health Physics
https://www.readbyqxmd.com/read/28541601/the-approach-to-coronary-bifurcation-treatment-and-its-outcomes-in-poland-the-single-center-experience
#18
Adam Kern, Robert J Gil, Krystian Bojko, Bartłomiej Rzeszowski, Rakesh Jalali, Jerzy Górny, Jacek Bil
BACKGROUND: Coronary bifurcation lesions pose therapeutic problems during percutaneous coronary interventions. The aim of this study was to analyze the strategy of coronary bifurcation treatment and associated angiographic as well as clinical outcomes in a large hospital in Northern Poland. METHODS: Between January 2012 and January 2014 patients with stable coronary artery disease or non-ST-elevation acute coronary syndrome (NSTE-ACS) were treated with regular drug-eluting stents (rDES) or dedicated bifurcation stents (BiOSS Expert® or BiOSS LIM®)...
May 25, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28541544/hemoglobin-glycation-index-is-associated-with-cardiovascular-diseases-in-people-with-impaired-glucose-metabolism
#19
Chang Ho Ahn, Se Hee Min, Dong-Wha Lee, Tae Jung Oh, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Kyong Soo Park, Hak Chul Jang, Joon Ha, Arthur Sherman, Soo Lim
Context: There is a substantial interindividual variation in the association between glycated hemoglobin (HbA1c) and plasma glucose concentrations. Its impact on cardiovascular disease (CVD) has not been comprehensively evaluated. Objective: We examined associations between interindividual variations in HbA1c, which was estimated as the hemoglobin glycation index (HGI), and CVD. Design, Setting, and Participants: We performed a cross-sectional analysis with 1248 treatment-naïve subjects with prediabetes or diabetes...
May 23, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28541499/hypertension-and-cardiac-arrhythmias-executive-summary-of-a-consensus-document-from-the-european-heart-rhythm-association-ehra-and-esc-council-on-hypertension-endorsed-by-the-heart-rhythm-society-hrs-asia-pacific-heart-rhythm-society-aphrs-and-sociedad-latinoamericana
#20
Gregory Y H Lip, Antonio Coca, Thomas Kahan, Giuseppe Boriani, Antonis S Manolis, Michael Hecht Olsen, Ali Oto, Tatjana S Potpara, Jan Steffel, Francisco Marín, Márcio Jansen de Oliveira Figueiredo, Giovanni de Simone, Wendy S Tzou, Chern En Chiang, Bryan Williams
Hypertension (HTN) is a common cardiovascular risk factor leading to heart failure (HF), coronary artery disease (CAD), stroke, peripheral artery disease and chronic renal failure. Hypertensive heart disease can manifest as many types of cardiac arrhythmias, most commonly being atrial fibrillation (AF). Both supraventricular and ventricular arrhythmias may occur in HTN patients, especially in those with left ventricular hypertrophy (LVH), CAD or HF. In addition, high doses of thiazide diuretics commonly used to treat hypertension, may result in electrolyte abnormalities (eg...
May 25, 2017: European Heart Journal. Cardiovascular Pharmacotherapy
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