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https://www.readbyqxmd.com/read/29353277/a-critical-review-of-the-consensus-statement-from-the-european-atherosclerosis-society-consensus-panel-2017
#1
Harumi Okuyama, Tomohito Hamazaki, Rokuro Hama, Yoichi Ogushi, Tetsuyuki Kobayashi, Naoki Ohara, Hajime Uchino
BACKGROUND: The Consensus Statement from the European Atherosclerosis Society (EAS) Consensus Panel 2017 concludes on the basis of 3 different types of clinical studies that low-density lipoprotein (LDL) causes atherosclerotic cardiovascular disease (ASCVD). In Mendelian randomization studies, rare genetic mutations affecting LDL receptor function were found to cause higher or lower LDL-C levels, which are associated with correspondingly altered ASCVD risk. In prospective cohort studies and randomized controlled trials (RCTs) of statins, a remarkably consistent log-linear association was demonstrated between the absolute magnitude of LDL-C exposure and ASCVD risk...
January 19, 2018: Pharmacology
https://www.readbyqxmd.com/read/29353228/association-of-lifelong-occupation-and-educational-level-with-subclinical-atherosclerosis-in-different-european-regions-results-from%C3%A2-the-improve-study
#2
Calogero C Tedesco, Fabrizio Veglia, Ulf de Faire, Sudhir Kurl, Andries J Smit, Rainer Rauramaa, Philippe Giral, Mauro Amato, Alice Bonomi, Alessio Ravani, Beatrice Frigerio, Samuela Castelnuovo, Daniela Sansaro, Elmo Mannarino, Steve E Humphries, Anders Hamsten, Elena Tremoli, Damiano Baldassarre
BACKGROUND AND AIMS: We aimed to examine the association between socioeconomic status (SES) and subclinical atherosclerosis, as assessed by carotid intima-media-thickness (C-IMT) and to investigate whether the effect of social inequality on C-IMT is mediated by cardiovascular (CV) risk factors and whether it is dissimilar in men and women, and in different European countries. METHODS: We assessed the association of lifelong occupation and educational level with C-IMT in the IMPROVE study cohort including 3703 subjects (median age 64...
December 20, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29353224/coronary-microvascular-dysfunction-may-be-related-to-igf-1-in-acromegalic-patients-and-can-be-restored-by-therapy
#3
Sara Tellatin, Pietro Maffei, Elena Osto, Francesca Dassie, Giulia Famoso, Roberta Montisci, Chiara Martini, Francesco Fallo, Martina Perazzolo Marra, Roberto Mioni, Sabino Iliceto, Roberto Vettor, Francesco Tona
BACKGROUND AND AIMS: Acromegaly increases the risk of cardiovascular mortality. Data on the cardiovascular risk in asymptomatic acromegaly are limited. In particular, data on coronary microvascular abnormalities are lacking. We assessed coronary flow reserve (CFR) as a marker of coronary microvascular function in asymptomatic acromegaly. METHODS: We studied 40 acromegalic patients (23 male, age 52 ± 11 years) without clinical evidence of cardiovascular disease, and 40 control subjects matched for age and sex...
December 24, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29353219/blocking-mitochondrial-cyclophilin-d-ameliorates-tsh-impaired-defensive-barrier-of-artery
#4
Xiaojing Liu, Heng Du, Qiang Chai, Qing Jia, Lu Liu, Meng Zhao, Jun Li, Hui Tang, Wenbin Chen, Lifang Zhao, Li Fang, Ling Gao, Jiajun Zhao
AIMS: Endothelial cells (ECs) constitute the defensive barrier of vasculature, which maintains the vascular homeostasis. Mitochondrial oxidative stress (mitoOS) in ECs significantly affects the initiation and progression of vascular diseases. The higher serum thyroid stimulating hormone (TSH) level is being recognized as a nonconventional risk factor responsible for the increased risk of cardiovascular diseases in subclinical hypothyroidism (SCH). However, effects and underlying mechanisms of elevated TSH on ECs are still ambiguous...
January 9, 2018: Redox Biology
https://www.readbyqxmd.com/read/29353160/prediction-of-venous-thromboembolism-using-semantic-and-sentiment-analyses-of-clinical-narratives
#5
Susan Sabra, Khalid Mahmood Malik, Mazen Alobaidi
Venous thromboembolism (VTE) is the third most common cardiovascular disorder. It affects people of both genders at ages as young as 20 years. The increased number of VTE cases with a high fatality rate of 25% at first occurrence makes preventive measures essential. Clinical narratives are a rich source of knowledge and should be included in the diagnosis and treatment processes, as they may contain critical information on risk factors. It is very important to make such narrative blocks of information usable for searching, health analytics, and decision-making...
January 3, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29353125/relationship-between-serum-trimethylamine-n-oxide-and-exposure-to-dioxin-like-pollutants
#6
Michael C Petriello, Richard Charnigo, Manjula Sunkara, Sony Soman, Marian Pavuk, Linda Birnbaum, Andrew J Morris, Bernhard Hennig
Trimethylamine N-oxide (TMAO) is a diet and gut microbiota-derived metabolite that has been linked to cardiovascular disease risk in human studies and animal models. TMAO levels show wide inter and intra individual variability in humans that can likely be accounted for by multiple factors including diet, the gut microbiota, levels of the TMAO generating liver enzyme Flavin-containing monooxygenase 3 (FMO3) and kidney function. We recently found that dioxin-like (DL) environmental pollutants increased FMO3 expression to elevate circulating diet-derived TMAO in mice, suggesting that exposure to this class of pollutants might also contribute to inter-individual variability in circulating TMAO levels in humans...
January 16, 2018: Environmental Research
https://www.readbyqxmd.com/read/29353099/cardiovascular-involvement-in-systemic-rheumatic-diseases-an-integrated-view-for-the-treating-physicians
#7
REVIEW
Kwang Seob Lee, Andreas Kronbichler, Michael Eisenhut, Keum Hwa Lee, Jae Il Shin
Systemic autoimmune diseases can affect various kinds of organs including the kidney, the skin, soft tissue and the bone. Among others, cardiovascular involvement in rheumatic diseases has been shown to affect myocardium, pericardium, cardiac vessels, conduction system and valves, eventually leading to mortality. In general, underlying chronic inflammation lead to premature atherosclerosis, but also other manifestations such as arrhythmia and heart failure may have a 'silent' progress. Traditional cardiovascular risk factors play a secondary role, while disease-specific factors (i...
January 15, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29352861/erica-age-at-menarche-and-its-association-with-nutritional-status
#8
Bruna de Siqueira Barros, Maria Cristina Maria Caetano Kuschnir, Katia Vergetti Bloch, Thiago Luiz Nogueira da Silva
OBJECTIVE: To estimate the mean age at menarche and its association with nutritional status in Brazilian adolescents. METHODS: The study sample included female adolescents aged 12-17 who participated in a multicenter, school-based, country-wide, cross-sectional study entitled The Study of Cardiovascular Risk in Adolescents (Estudo de Riscos Cardiovasculares em Adolescentes [ERICA]). Mean and median ages at menarche in Brazil were estimated. The association of age at menarche with sociodemographic data and nutritional status were described as means and their respective 95% confidence intervals...
January 18, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29352421/predictors-of-insulin-initiation-in-patients-with-type-2-diabetes-an-analysis-of-the-look-ahead-randomized-trial
#9
Scott J Pilla, Hsin-Chieh Yeh, Stephen P Juraschek, Jeanne M Clark, Nisa M Maruthur
BACKGROUND: The decision to initiate insulin in patients with type 2 diabetes is a challenging escalation of care that requires an individualized approach. However, the sociodemographic and clinical factors affecting insulin initiation are not well understood. OBJECTIVE: We sought to identify patient factors that were independent predictors of insulin initiation among participants in the Look AHEAD (Action for Health in Diabetes) clinical trial. DESIGN: Retrospective analysis of a randomized clinical trial...
January 19, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29352093/excessive-daytime-sleepiness-independently-predicts-increased-cardiovascular-risk-after-myocardial-infarction
#10
Jiang Xie, Fatima H Sert Kuniyoshi, Naima Covassin, Prachi Singh, Apoor S Gami, C Anwar A Chahal, Virend K Somers
BACKGROUND: Excessive daytime sleepiness (EDS), a common symptom among patients with sleep-disordered breathing, is closely associated with the development of cardiovascular diseases, but its long-term prognostic value is not completely understood. The aim of this study was to investigate whether EDS would be an independent prognostic factor after myocardial infarction. METHODS AND RESULTS: We prospectively recruited 112 post-myocardial infarction patients. The Epworth Sleepiness Scale was completed before polysomnography, and EDS was defined as a score ≥11...
January 19, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29352092/incident-heart-failure-in-patients-with-rheumatoid-arthritis-a-nationwide-cohort-study
#11
Usman Khalid, Alexander Egeberg, Ole Ahlehoff, Deirdre Lane, Gunnar H Gislason, Gregory Y H Lip, Peter R Hansen
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with a wide range of comorbidities, including cardiovascular disease, but its association with heart failure (HF) is not fully clear. We investigated the risk of incident HF in a nationwide cohort of patients with RA. METHODS AND RESULTS: The study comprised the entire Danish population aged ≥18 years followed from January 1, 2008 until first hospitalization for HF, emigration, December 31, 2012, or death...
January 19, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29352008/incidence-predictors-and-clinical-outcomes-of-residual-stenosis-after-aortic-valve-in-valve
#12
Sabine Bleiziffer, Magdalena Erlebach, Matheus Simonato, Philippe Pibarot, John Webb, Lukas Capek, Stephan Windecker, Isaac George, Jan-Malte Sinning, Eric Horlick, Massimo Napodano, David M Holzhey, Petur Petursson, Alfredo Cerillo, Nikolaos Bonaros, Enrico Ferrari, Mauricio G Cohen, Giselle Baquero, Tara L Jones, Ankur Kalra, Michael J Reardon, Adnan Chhatriwalla, Vasco Gama Ribeiro, Sami Alnasser, Nicolas M Van Mieghem, Christian Jörg Rustenbach, Joachim Schofer, Santiago Garcia, Tobias Zeus, Didier Champagnac, Raffi Bekeredjian, Ran Kornowski, Rüdiger Lange, Danny Dvir
OBJECTIVE: We aimed to analyse the incidence of prosthesis-patient mismatch (PPM) and elevated gradients after aortic valve in valve (ViV), and to evaluate predictors and associations with clinical outcomes of this adverse event. METHODS: A total of 910 aortic ViV patients were investigated. Elevated residual gradients were defined as ≥20 mm Hg. PPM was identified based on the indexed effective orifice area (EOA), measured by echocardiography, and patient body mass index (BMI)...
January 19, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29352006/machine-learning-in-cardiovascular-medicine-are-we-there-yet
#13
REVIEW
Khader Shameer, Kipp W Johnson, Benjamin S Glicksberg, Joel T Dudley, Partho P Sengupta
Artificial intelligence (AI) broadly refers to analytical algorithms that iteratively learn from data, allowing computers to find hidden insights without being explicitly programmed where to look. These include a family of operations encompassing several terms like machine learning, cognitive learning, deep learning and reinforcement learning-based methods that can be used to integrate and interpret complex biomedical and healthcare data in scenarios where traditional statistical methods may not be able to perform...
January 19, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29351960/the-impact-of-diabetes-on-breast-cancer-treatments-and-outcomes-a-population-based-study
#14
Iliana C Lega, Peter C Austin, Hadas D Fischer, Kinwah Fung, Monika K Krzyzanowska, Eitan Amir, Lorraine L Lipscombe
OBJECTIVE: Women with breast cancer and diabetes face worse outcomes than those with breast cancer without diabetes; however, the contribution of comorbidity to these disparities remains unclear. We evaluated the impact of diabetes on receipt of cancer treatments as well as mortality while accounting for other comorbidities. RESEARCH DESIGN AND METHODS: Ontario administrative databases were used to compare the rate of receipt of breast cancer treatments between women with and without diabetes...
January 19, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29351855/the-relationship-of-circulating-fibroblast-growth-factor-21-levels-with-incident-atrial-fibrillation-the-multi-ethnic-study-of-atherosclerosis
#15
Tsz Him Hui, Robyn L McClelland, Matthew A Allison, Carlos J Rodriguez, Richard A Kronmal, Susan R Heckbert, Erin D Michos, Philip J Barter, Kerry-Anne Rye, Kwok Leung Ong
BACKGROUND AND AIMS: Elevated circulating levels of fibroblast growth factor 21 (FGF21) are associated with multiple cardiovascular disease (CVD) risk factors and incident events. Previous small cross-sectional studies, mainly in Chinese populations, have suggested FGF21 may play a role in the development of atrial fibrillation (AF). We therefore investigated the relationship of FGF21 levels with incident AF in participants free of clinically apparent CVD at baseline in a large, multi-ethnic cohort...
December 25, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29351490/significant-improvement-in-cardiometabolic-health-in-healthy-non-obese-individuals-during-caloric-restriction-induced-weight-loss-and-weight-loss-maintenance
#16
Jasper Most, L Anne Gilmore, Steven R Smith, Hongmei Han, Eric Ravussin, Leanne M Redman
Caloric restriction (CR) triggers benefits for healthspan including decreased risk of cardiometabolic disease. In an ancillary study to CALERIE 2, a 24-month 25% CR study, we assessed the cardiometabolic effects of CR in 53 non-obese (BMI: 22-28 kg/m2) men (n=17) and women (n=36). According to the energy-balance method (doubly labeled water and changes in body energy stores), the 25% CR intervention (n=34) produced 17{plus minus}1% (mean{plus minus}SE) and 14{plus minus}1% CR after 12 and 24 months (M12, M24), resulting in significant weight loss (M12: -9{plus minus}0...
December 12, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29351480/mechanistically-different-effects-of-fat-and-sugar-on-insulin-resistance-hypertension-and-gut-microbiota-in-rats
#17
Sara Ramos-Romero, Mercè Hereu, Lidia Atienza, Josefina Casas, Olga Jáuregui, Susana Amézqueta, Gabriel Dasilva, Isabel Medina, Maria Rosa Nogués, Marta Romeu, Josep Lluís Torres
Insulin resistance (IR) and impaired glucose tolerance (IGT) are the first manifestations of diet-induced metabolic alterations leading to type-2 diabetes, while hypertension is the deadliest risk factor of cardiovascular disease. The roles of dietary fat and fructose in the development of IR, IGT and hypertension are controversial. We tested the long-term effects of an excess of fat or sucrose (fructose/glucose) on healthy male Wistar Kyoto (WKY) rats. Fat affects IR and IGT earlier than fructose through low-grade systemic inflammation evidenced by liver inflammatory infiltration, increased levels of plasma interleukin-6, prostaglandin E2 and reduced levels of protective short-chain fatty acids without triggering hypertension...
January 2, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29351115/synergistic-increase-in-cardiovascular-risk-in-diabetes-mellitus-with-nonalcoholic-fatty-liver-disease-a-meta-analysis
#18
Yao-Yao Zhou, Xiao-Dong Zhou, Sheng-Jie Wu, Xian-Qing Hu, Biao Tang, Sven van Poucke, Xiao-Yan Pan, Wen-Jun Wu, Xue-Mei Gu, Shen-Wen Fu, Ming-Hua Zheng
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) has been linked to an increased risk of cardiovascular disease (CVD). To explore the impact of diabetes mellitus (DM) as a cardiovascular risk factor, this meta-analysis quantitatively assessed the association of NAFLD and CVD in diabetic patients. METHODS: PubMed, EMBASE, and the Cochrane Library database were analyzed until the end of March 2017. Original studies analyzing the association between NAFLD and cardiovascular risk factors in the diabetic population were included...
January 18, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29350569/practice-pearl-liraglutide-and-cardiovascular-and-renal-events-in-type-2-diabetes
#19
Robert Guthrie
Review of: Marso S, Daniels G, Brown-Frandsen K, et al. Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med 2016; 375: 311-322. Mann J, Orsted D, Brown-Frandsen K, et al. Liraglutide and Renal Outcomes in Type 2 Diabetes. N Engl J Med 2017; 377: 839-848. This comprehensive research project, LEADER, led to two reports, one focusing on the effect of liraglutide on cardiovascular events, and the second one reporting on the renal effects on the same study population. The study group included 9340 patients with type 2 diabetes...
January 19, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29350393/is-it-possible-to-improve-compliance-in-hypertension-and-reduce-therapeutic-inertia-of-physicians-by-mandatory-periodical-examinations-of-workers
#20
Andrzej Marcinkiewicz, Michał Plewka, Wojciech Hanke, Paweł Kałużny, Marta Wiszniewska, Agnieszka Lipińska-Ojrzanowska, Jolanta Walusiak-Skorupa
BACKGROUND: Due to high prevalence, insufficient recognition and ineffectual treatment, hypertension (HT) still remains a major medical and socio-economic problem. There is a real necessity to develop effective prophylaxis for cardiovascular disorders (CVD), based on strategies which support compliance during long-term therapy. The Polish scheme of occupational health services (OHS) with mandatory periodical employee check-ups creates a unique opportunity for effective HT prophylaxis...
January 19, 2018: Kardiologia Polska
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