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https://www.readbyqxmd.com/read/29334475/abandonment-of-assistive-products-assessing-abandonment-levels-and-factors-that-impact-on-it
#1
André T Sugawara, Vinícius D Ramos, Fábio M Alfieri, Linamara R Battistella
PURPOSE: To investigate the levels and factors that influence the abandonment of assistive products by users of a local reference rehabilitation center. METHODS: This observational study involved users who received services and assistive products provided by our center of rehabilitation. Users were identified using the records of the center and their responses about the abandonment were collected through face-to-face interviews. RESULTS: The abandonment level of assistive products was 19...
January 15, 2018: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29334203/modeling-in-vitro-fertilization-data-considering-multiple-outcomes-observed-among-iranian-infertile-women
#2
Azadeh Ghaheri, Aliakbar Rasekhi, Reza Omani Samani, Ebrahim Hajizadeh
Background: Women undergoing in vitro fertilization (IVF) cycles should successfully go through multiple points during the procedure (i.e., implantation, clinical pregnancy, no spontaneous abortion and delivery) to achieve live births. In this study, data from multiple cycles and multiple points during the IVF cycle are collected for each individual to model the effects of factors associated with success at different stages of IVF cycles in Iranian infertile women. MATERIALS AND METHODS: This historical cohort study includes 996 assisted reproductive technology (ART) cycles of 511 infertile women...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29334198/enzyme-based-glucose-sensor-from-invasive-to-wearable-device
#3
REVIEW
Hyunjae Lee, Yongseok Joseph Hong, Seungmin Baik, Taeghwan Hyeon, Dae-Hyeong Kim
Blood glucose concentration is a key indicator of patients' health, particularly for symptoms associated with diabetes mellitus. Because of the large number of diabetic patients, many approaches for glucose measurement have been studied to enable continuous and accurate glucose level monitoring. Among them, electrochemical analysis is prominent because it is simple and quantitative. This technology has been incorporated into commercialized and research-level devices from simple test strips to wearable devices and implantable systems...
January 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29334092/synthetic-cells-produce-a-quorum-sensing-chemical-signal-perceived-by-pseudomonas-aeruginosa
#4
Giordano Rampioni, Francesca D'Angelo, Marco Messina, Alessandro Zennaro, Yutetsu Kuruma, Daniela Tofani, Livia Leoni, Pasquale Stano
Recent developments in bottom-up synthetic biology (e.g., lipid vesicle technology integrated with cell-free protein expression systems) allow the generation of semi-synthetic minimal cells (in short, synthetic cells, SCs) endowed with some distinctive capacities of natural cells. In particular, such approaches provide technological tools and conceptual frameworks for the design and engineering of programmable SCs capable of communicating with natural cells by exchanging chemical signals. Here we describe the generation of giant vesicle-based SCs which, via gene expression, synthesize in their aqueous lumen an enzyme that in turn produces a chemical signal...
January 15, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29332060/information-technology-as-a-tool-for-the-italian-institute-of-social-security-inps-in-the-management-of-social-security-and-civil-disability-pro-and-cons
#5
Michele Sammicheli, Marcella Scaglione
We examine, from a medical-legal perspective, the pro and cons of the information technology procedures that the Italian Institute of Social Security (INPS) has implemented to manage the provision of social disability assistance, meaning that separate from the payment of pension contributions, being welfare, anchored to an administrative requirement by way of the compulsory payment of a minimum social security contribution.
January 5, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29331453/are-privacy-enhancing-technologies-for-genomic-data-ready-for-the-clinic-a-survey-of-medical-experts-of-the-swiss-hiv-cohort-study
#6
Jean-Louis Raisaro, Paul J McLaren, Jacques Fellay, Matthias Cavassini, Catherine Klersy, Jean-Pierre Hubaux
PURPOSE: Protecting patient privacy is a major obstacle for the implementation of genomic-based medicine. Emerging privacy-enhancing technologies can become key enablers for managing sensitive genetic data. We studied physicians' attitude toward this kind of technology in order to derive insights that might foster their future adoption for clinical care. METHODS: We conducted a questionnaire-based survey among 55 physicians of the Swiss HIV Cohort Study who tested the first implementation of a privacy-preserving model for delivering genomic test results...
January 10, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29331258/clinician-user-involvement-in-the-real-world-designing-an-electronic-tool-to-improve-interprofessional-communication-and-collaboration-in-a-hospital-setting
#7
Terence Tang, Morgan E Lim, Elizabeth Mansfield, Alexander McLachlan, Sherman D Quan
OBJECTIVES: User involvement is vital to the success of health information technology implementation. However, involving clinician users effectively and meaningfully in complex healthcare organizations remains challenging. The objective of this paper is to share our real-world experience of applying a variety of user involvement methods in the design and implementation of a clinical communication and collaboration platform aimed at facilitating care of complex hospitalized patients by an interprofessional team of clinicians...
February 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29331256/measuring-non-administration-of-ordered-medications-in-the-pediatric-inpatient-setting
#8
Haresh L Bhatia, Neal R Patel, Catherine H Ivory, Phillip W Stewart, Kim M Unertl, Christoph U Lehmann
OBJECTIVE: Medication compliance in inpatient settings shows some significant gaps for adult patients. In pediatric settings prescribing and other administration errors have been studied but missed doses have not been specifically studied in the pediatric inpatient setting. We intended to apply health information technology and data processing methods to study the medication compliance for pediatric patients at our institution. STUDY DESIGN: We collected medication ordering, dispensing, and administration data spanning 42 months (7/1/2010 through 12/31/2013) for pediatric inpatients admitted to a major tertiary pediatric hospital...
February 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29331254/technology-alignment-in-the-presence-of-regulatory-changes-the-case-of-meaningful-use-of-information-technology-in-healthcare
#9
Anand Nair, David Dreyfus
OBJECTIVES: Using the context of the healthcare sector, this study examines the impact of regulatory change on technology implementation and use. Hospitals are now federally mandated to showcase meaningful use of information technology (IT). We theorize that IT plan scope structured prior to a regulatory change by means of a long-term planning horizon, top management involvement, and steering committee engagement impacts organizations' ability to fulfill meaningful use requirements three to five years later...
February 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29331252/investigating-the-need-for-clinicians-to-use-tablet-computers-with-a-newly-envisioned-electronic-health-record
#10
Jason J Saleem, April Savoy, Gale Etherton, Jennifer Herout
OBJECTIVE: The Veterans Health Administration (VHA) has deployed a large number of tablet computers in the last several years. However, little is known about how clinicians may use these devices with a newly planned Web-based electronic health record (EHR), as well as other clinical tools. The objective of this study was to understand the types of use that can be expected of tablet computers versus desktops. METHODS: Semi-structured interviews were conducted with 24 clinicians at a Veterans Health Administration (VHA) Medical Center...
February 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29331251/bridging-clinical-researcher-perceptions-and-health-it-realities-a-case-study-of-stakeholder-creep
#11
Daniel J Panyard, Edmond Ramly, Shannon M Dean, Christie M Bartels
PURPOSE: We present a case report detailing a challenge in health information technology (HIT) project implementations we term "stakeholder creep": not thoroughly identifying which stakeholders need to be involved and why before starting a project, consequently not understanding the true effort, skill sets, social capital, and time required to complete the project. METHODS: A root cause analysis was performed post-implementation to understand what led to stakeholder creep...
February 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29331248/usability-evaluation-of-a-commercial-inpatient-portal
#12
Po-Yin Yen, Daniel M Walker, Jessica M Garvey Smith, Michelle P Zhou, Terri L Menser, Ann Scheck McAlearney
OBJECTIVES: Patient portals designed for inpatients have potential to increase patient engagement. However, little is known about how patients use inpatient portals. To address this gap, we aimed to understand how users 1) interact with, 2) learn to use, and 3) communicate with their providers through an inpatient portal. MATERIALS AND METHODS: We conducted a usability evaluation using think-aloud protocol to study user interactions with a commercially available inpatient portal - MyChart Bedside (MCB)...
February 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29330875/performance-of-the-early-access-ampliseq%C3%A2-mitochondrial-panel-with-degraded-dna-samples-using-the-ion-torrent%C3%A2-platform
#13
Ka Tak Wai, Mark Barash, Peter Gunn
The Early Access AmpliSeq™ Mitochondrial Panel amplifies whole mitochondrial genomes for phylogenetic and kinship identifications, using Ion Torrent™ technology. There is currently limited information on its performance with degraded DNA, a common occurrence in forensic samples. This study evaluated the performance of the Panel with DNA samples degraded in vitro, to mimic conditions commonly found in forensic investigations. Purified DNA from five individuals was heat-treated at five time points each (125°C for 0, 30, 60, 120 and 240 minutes; total n = 25)...
January 13, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29330710/glycogen-production-in-marine-cyanobacterial-strain-synechococcus-sp-nkbg-15041c
#14
Amr Badary, Shouhei Takamatsu, Mitsuharu Nakajima, Stefano Ferri, Peter Lindblad, Koji Sode
An important feature offered by marine cyanobacterial strains over freshwater strains is the capacity to grow in seawater, replacing the need for often-limited freshwater. However, there are only limited numbers of marine cyanobacteria that are available for genetic manipulation and bioprocess applications. The marine unicellular cyanobacteria Synechococcus sp. strain NKBG 15041c (NKBG15041c) has been extensively studied. Recombinant DNA technologies are available for this strain, and its genomic information has been elucidated...
January 12, 2018: Marine Biotechnology
https://www.readbyqxmd.com/read/29330674/advances-in-serological-imaging-techniques-and-molecular-diagnosis-of-toxoplasma-gondii-infection
#15
REVIEW
Ali Rostami, Panagiotis Karanis, Shirzad Fallahi
BACKGROUND: Toxoplasmosis is worldwide distributed zoonotic infection disease with medical importance in immunocompromised patients, pregnant women and congenitally infected newborns. Having basic information on the traditional and new developed methods is essential for general physicians and infectious disease specialists for choosing a suitable diagnostic approach for rapid and accurate diagnosis of the disease and, consequently, timely and effective treatment. METHODS: We conducted English literature searches in PubMed from 1989 to 2016 using relevant keywords and summarized the recent advances in diagnosis of toxoplasmosis...
January 12, 2018: Infection
https://www.readbyqxmd.com/read/29330500/integration-of-gwas-pathway-and-network-analyses-reveals-novel-mechanistic-insights-into-the-synthesis-of-milk-proteins-in-dairy-cows
#16
Sara Pegolo, Núria Mach, Yuliaxis Ramayo-Caldas, Stefano Schiavon, Giovanni Bittante, Alessio Cecchinato
The quantities and proportions of protein fractions have notable effects on the nutritional and technological value of milk. Although much is known about the effects of genetic variants on milk proteins, the complex relationships among the set of genes and pathways regulating the different protein fractions synthesis and secretion into milk in dairy cows are still not completely understood. We conducted genome-wide association studies (GWAS) for milk nitrogen fractions in a cohort of 1,011 Brown Swiss cows, which uncovered 170 significant single nucleotide polymorphism (SNPs), mostly located on BTA6 and BTA11...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330360/fibre-optic-metadevice-for-all-optical-signal-modulation-based-on-coherent-absorption
#17
Angelos Xomalis, Iosif Demirtzioglou, Eric Plum, Yongmin Jung, Venkatram Nalla, Cosimo Lacava, Kevin F MacDonald, Periklis Petropoulos, David J Richardson, Nikolay I Zheludev
Recently, coherent control of the optical response of thin films in standing waves has attracted considerable attention, ranging from applications in excitation-selective spectroscopy and nonlinear optics to all-optical image processing. Here, we show that integration of metamaterial and optical fibre technologies allows the use of coherently controlled absorption in a fully fiberized and packaged switching metadevice. With this metadevice, which controls light with light in a nanoscale plasmonic metamaterial film on an optical fibre tip, we provide proof-of-principle demonstrations of logical functions XOR, NOT and AND that are performed within a coherent fibre network at wavelengths between 1530 and 1565 nm...
January 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29330132/an-overview-of-the-safety-pharmacology-society-strategic-plan
#18
M K Pugsley, S Authier, J E Koerner, W S Redfern, C G Markgraf, T Brabham, K Correll, M V Soloviev, A Botchway, M Engwall, M Traebert, J-P Valentin, T J Mow, A Greiter-Wilke, D J Leishman, H M Vargas
Safety Pharmacology studies are conducted to characterize the confidence by which biologically active new chemical entities (NCE) may be anticipated as safe. Non-clinical safety pharmacology studies aim to detect and characterize potentially undesirable pharmacodynamic activities using an array of in silico, in vitro and in vivo animal models. While a broad spectrum of methodological innovation and advancement of the science occurs within the Safety Pharmacology Society, the society also focuses on partnerships with health authorities and technology providers and facilitates interaction with organizations of common interest such as pharmacology, physiology, neuroscience, cardiology and toxicology...
January 9, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29330100/osteoarthritis-year-in-review-2017-updates-on-imaging-advancements
#19
REVIEW
Nima Hafezi-Nejad, Shadpour Demehri, Ali Guermazi, John A Carrino
OBJECTIVE: This narrative review covers original research publications related to imaging advancements in osteoarthritis (OA) published in the English language between 1st April 2016 and 30th April 2017. METHODS: Relevant human studies (excluding pre-clinical and in-vitro studies), were searched and selected from PubMed database using the search terms of "osteoarthritis (OA)" in combination with "radiography", "magnetic resonance imaging (MRI)", "computed tomography (CT)", "ultrasound", "positron emission tomography (PET)," "single-photon emission computed tomography (SPECT)," and "scintigraphy"...
January 9, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29329980/a-mass-spectrometry-imaging-approach-for-investigating-how-drug-drug-interactions-influence-drug-blood-brain-barrier-permeability
#20
Theodosia Vallianatou, Nicole Strittmatter, Anna Nilsson, Mohammadreza Shariatgorji, Gregory Hamm, Marcela Pereira, Patrik Källback, Per Svenningsson, Maria Karlgren, Richard J A Goodwin, Per E Andrén
There is a high need to develop quantitative imaging methods capable of providing detailed brain localization information of several molecular species simultaneously. In addition, extensive information on the effect of the blood-brain barrier on the penetration, distribution and efficacy of neuroactive compounds is required. Thus, we have developed a mass spectrometry imaging method to visualize and quantify the brain distribution of drugs with varying blood-brain barrier permeability. With this approach, we were able to determine blood-brain barrier transport of different drugs and define the drug distribution in very small brain structures (e...
January 9, 2018: NeuroImage
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