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https://www.readbyqxmd.com/read/29141040/medical-therapy-versus-radiofrequency-endometrial-ablation-in-the-initial-treatment-of-heavy-menstrual-bleeding-itom-trial-a-clinical-and-economic-analysis
#1
Abimbola O Famuyide, Shannon K Laughlin-Tommaso, Sherif A Shazly, Kirsten Hall Long, Daniel M Breitkopf, Amy L Weaver, Michaela E McGree, Sherif A El-Nashar, Maureen A Lemens, Matthew R Hopkins
BACKGROUND: Radiofrequency endometrial ablation (REA) is currently a second line treatment in women with heavy menstrual bleeding (MHB) if medical therapy (MTP) is contraindicated or unsatisfactory. Our objective is to compare the effectiveness and cost burden of MTP and REA in the initial treatment of HMB. METHODS: We performed a randomized trial at Mayo Clinic Rochester, Minnesota. The planned sample size was 60 patients per arm. A total of 67 women with HMB were randomly allocated to receive oral contraceptive pills (Nordette ®) or Naproxen (Naprosyn®) (n = 33) or REA (n = 34)...
2017: PloS One
https://www.readbyqxmd.com/read/29139105/preoperative-medical-therapy-before-surgery-for-uterine-fibroids
#2
REVIEW
Anne Lethaby, Lucian Puscasiu, Beverley Vollenhoven
BACKGROUND: Uterine fibroids occur in up to 40% of women aged over 35 years. Some are asymptomatic, but up to 50% cause symptoms that warrant therapy. Symptoms include anaemia caused by heavy menstrual bleeding, pelvic pain, dysmenorrhoea, infertility and low quality of life. Surgery is the first choice of treatment. In recent years, medical therapies have been used before surgery to improve intraoperative and postoperative outcomes. However, such therapies tend to be expensive.Fibroid growth is stimulated by oestrogen...
November 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29125963/a-capillary-electrophoresis-method-for-identifying-forensically-relevant-body-fluids-using-mirnas
#3
Carrie Mayes, Sarah Seashols-Williams, Sheree Hughes-Stamm
Body fluid identification (BFID) can provide crucial information during the course of an investigation. In recent years, microRNAs (miRNAs) have shown considerable body fluid specificity, are able to be co-extracted with DNA, and their small size (18-25 nucleotides) make them ideal for analyzing highly degraded forensic samples. In this study, we designed a preliminary 8-marker system for BFID including an endogenous reference gene (let-7g) to differentiate between venous blood (miR-451a and miR-142-3p), menstrual blood (miR-141-3p and miR-412-3p), semen (miR-891a and miR-10b), and saliva (miR-205) using a capillary electrophoresis approach...
October 31, 2017: Legal Medicine
https://www.readbyqxmd.com/read/29124543/determinants-of-prolactin-in-postmenopausal-chinese-women-in-singapore
#4
Tiffany A Katz, Anna H Wu, Frank Z Stanczyk, Renwei Wang, Woon-Puay Koh, Jian-Min Yuan, Steffi Oesterreich, Lesley M Butler
PURPOSE: Mechanistic and observational data together support a role for prolactin in breast cancer development. Determinants of prolactin in Asian populations have not been meaningfully explored, despite the lower risk of breast cancer in Asian populations. METHODS: Determinants of plasma prolactin were evaluated in 442 postmenopausal women enrolled in the Singapore Chinese Health Study, a population-based prospective cohort study. At baseline all cohort members completed an in-person interview that elicited information on diet, menstrual and reproductive history, and lifestyle factors...
November 9, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29112593/age-related-changes-in-luteal-dynamics-preliminary-associations-with-antral-follicular-dynamics-and-hormone-production-during-the-human-menstrual-cycle
#5
Angela Baerwald, Heidi Vanden Brink, Caitlin Hunter, Denae Beuker, Hyun Lim, Chel Hee Lee, Donna Chizen
OBJECTIVE: The aim of the study was to test the hypothesis that the development of luteal phase dominant follicles (LPDFs) as women age is associated with abnormal luteal function. METHODS: Luteal and antral follicle diameter were quantified in ovulatory women of midreproductive age (MRA; 18-35 y; n = 9) and advanced reproductive age (ARA; 45-55 y; n = 16) every 1 to 3 days during one complete interovulatory interval. Blood was drawn at each visit and assayed for progesterone, estradiol, inhibin A, follicle-stimulating hormone, and luteinizing hormone...
November 6, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29107739/comparative-restoration-of-acute-liver-failure-by-menstrual-blood-stem-cells-compared-with-bone-marrow-stem-cells-in-mice-model
#6
Mina Fathi-Kazerooni, Gholamreza Tavoosidana, Masoud Taghizadeh-Jahed, Sayeh Khanjani, Hananeh Golshahi, Caroline E Gargett, Haleh Edalatkhah, Somaieh Kazemnejad
BACKGROUND AIMS: The application of menstrual blood stem cells (MenSCs) in regenerative medicine is gaining increasing attention. The aim of this study was to investigate the therapeutic potential of MenSCs compared with bone marrow-derived stem cells (BMSCs) in an animal model of CCl4-induced acute hepatic failure. METHODS: Injured Balb/C mice were divided into multiple groups and received MenSCs, BMSCs or hepatocyte progenitor-like (HPL) cells derived from these cells...
October 26, 2017: Cytotherapy
https://www.readbyqxmd.com/read/29105518/relationship-between-serum-anti-mullerian-hormone-with-vitamin-d-and-metabolic-syndrome-risk-factors-in-late-reproductive-age-women
#7
Sunmie Kim, Jin Ju Kim, Min-Jeong Kim, Kyung Hee Han, Jung Ryeol Lee, Chang Suk Suh, Young Min Choi, Seok Hyun Kim
The relationship between serum anti-Mullerian hormone (AMH) with vitamin D (25OH-D) and metabolic syndrome (MetS) risk was evaluated in healthy, late reproductive-age (35-49 years) women with regular menstrual cycles. Among the 291 participants (mean age = 42.5 years), most (76.6%, n = 223) were serum vitamin D insufficient (<20 ng/ml). Mean serum levels of AMH and vitamin D were 2.04 ng/mL and 15.9 ng/mL, respectively. There was no correlation between AMH and 25OH-D after adjustment for age (r = -0...
November 5, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29099850/determinants-of-severe-anemia-among-laboring-mothers-in-mekelle-city-public-hospitals-tigray-region-ethiopia
#8
Yirga Ebuy, Mussie Alemayehu, Mengistu Mitiku, Gelila K Goba
INTRODUCTION: Anemia is a global public health problem that has affected a significant number of pregnant mothers worldwide. The World Health Organization has estimated the prevalence of anemia in pregnant women at 18% and 56% in developed and developing countries, respectively. This study aimed to identify factors associated with severe anemia among laboring women in Mekelle city public hospitals, Tigray, Ethiopia. METHODS: This unmatched case-control study involved 264 (88 = cases and 176 = controls) pregnant women who were recruited when they came for delivery service in Mekelle city public hospitals...
2017: PloS One
https://www.readbyqxmd.com/read/29083061/the-impact-of-menstrual-phase-on-brachial-artery-flow-mediated-dilation-during-handgrip-exercise-in-healthy-premenopausal-women
#9
Katrina A D'Urzo, Trevor J King, Jennifer S Williams, Morgan D Silvester, Kyra E Pyke
Flow-mediated dilation (FMD) in response to a sustained shear stress stimulus (e.g. via handgrip exercise; HGEX) is emerging as a useful tool for assessing endothelial function; however, the impact of menstrual phase on HGEX-FMD is unknown. The purpose of this study was to determine whether HGEX-FMD fluctuates with cyclical changes in estrogen levels over two discrete phases (low and high estrogen) of the menstrual cycle. Brachial artery (BA) diameter and blood velocity were assessed with 2D and Doppler ultrasound, respectively...
October 30, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29075170/correlation-of-hba1c-levels-with-body-mass-index-in-newly-diagnosed-polycystic-ovary-syndrome
#10
Manju Bala, Meenakshi, Menaka K, Anjali Gupta
INTRODUCTION: Polycystic ovary syndrome (PCOS) is a heterogeneous, multisystem endocrinopathy in women of reproductive age manifested with various metabolic disturbances and a wide spectrum of clinical features such as obesity, menstrual abnormalities and hyperandrogenism. Hyperinsulinemia was noted in 50% to 70% of PCOS patients and plays a central role in the development of further complications. The prevalence of obesity in PCOS ranges from 38% to 87%. It has been reported in previous studies that the prevalence of insulin resistance (IR) is higher in obese PCOS women than obesity without PCOS...
October 2017: EJIFCC
https://www.readbyqxmd.com/read/29072794/effects-of-gaba-active-steroids-in-the-female-brain-with-focus-on-the-premenstrual-dysphoric-disorder
#11
REVIEW
Marie Bixo, Maja Johansson, Erika Timby, Louise Michalski, Torbjörn Bäckström
PMDD (premenstrual dysphoric disorder) afflicts 3-5% of women of childbearing age, and is characterized by recurrent negative mood symptoms, e.g. irritability, depression, anxiety and emotional lability during the luteal phase of the menstrual cycle. The etiology of PMDD is unknown, but a temporal association with circulating ovarian steroids, in particular progesterone and its metabolite allopregnanolone, during the luteal phase has been established. Allopregnanolone is a positive modulator of the GABAA receptor: it is sedative in high concentrations, but may precipitate paradoxical adverse effects on mood at levels corresponding to luteal phase concentrations in susceptible women...
October 26, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29068243/evidence-for-disruption-of-normal-circadian-cortisol-rhythm-in-women-with-obesity
#12
Zain A Al-Safi, Alex Polotsky, Justin Chosich, Lauren Roth, Amanda A Allshouse, Andrew P Bradford, Nanette Santoro
Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis may play a role in the pathogenesis of comorbidities encountered in obesity, including the relative hypogonadotropic hypogonadism that we and others have observed. We sought to examine serum cortisol profiles throughout the day and evening in a sample of normal weight women and women with obesity. In this cross-sectional study, regularly cycling obese (n = 12) and normal weight (n = 10) women were recruited. Mean serum cortisol was measured by frequent blood sampling for 16 h (8am-midnight) in the luteal phase of the menstrual cycle...
October 25, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29066045/medical-therapy-for-fibroids-an-overview
#13
REVIEW
Vikram Sinai Talaulikar
Uterine fibroids are the most common benign tumours in women of reproductive age group and are a cause of significant healthcare burden. Although surgical treatments have been the traditional gold standard for symptomatic uterine fibroids, several medical therapeutic approaches have been used to achieve symptom suppression in women who wish to preserve their uterus or are at elevated risk of complications during surgery. Medical therapies used for uterine fibroids include tranexamic acid, NSAIDs, contraceptive steroids, progesterone coil, GnRH analogues, aromatase inhibitors, SERMs and progesterone receptor modulators...
September 28, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29058082/forensic-differentiation-between-peripheral-and-menstrual-blood-in-cases-of-alleged-sexual-assault-validating-an-immunochromatographic-multiplex-assay-for-simultaneous-detection-of-human-hemoglobin-and-d-dimer
#14
Hannah Holtkötter, Claudemir Rodrigues Dias Filho, Kristina Schwender, Christian Stadler, Marielle Vennemann, Ana Claudia Pacheco, Gabriela Roca
Sexual assault is a serious offense and identification of body fluids originating from sexual activity has been a crucial aspect of forensic investigations for a long time. While reliable tests for the detection of semen and saliva have been successfully implemented into forensic laboratories, the detection of other body fluids, such as vaginal or menstrual fluid, is more challenging. Especially, the discrimination between peripheral and menstrual blood can be highly relevant for police investigations because it provides potential evidence regarding the issue of consent...
October 23, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29049585/association-between-biomarkers-of-ovarian-reserve-and-infertility-among-older-women-of-reproductive-age
#15
Anne Z Steiner, David Pritchard, Frank Z Stanczyk, James S Kesner, Juliana W Meadows, Amy H Herring, Donna D Baird
Importance: Despite lack of evidence of their utility, biomarkers of ovarian reserve are being promoted as potential markers of reproductive potential. Objective: To determine the associations between biomarkers of ovarian reserve and reproductive potential among women of late reproductive age. Design, Setting, and Participants: Prospective time-to-pregnancy cohort study (2008 to date of last follow-up in March 2016) of women (N = 981) aged 30 to 44 years without a history of infertility who had been trying to conceive for 3 months or less, recruited from the community in the Raleigh-Durham, North Carolina, area...
October 10, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29033580/the-influence-of-vascular-endothelial-growth-factor-a-and-matrix-metalloproteinase-2-and-9-in-angiogenesis-metastasis-and-prognosis-of-endometrial-cancer
#16
REVIEW
Anna M Mahecha, Hongbo Wang
Angiogenesis (the growth of new blood vessels) is essential in most of the body's physiological processes, such as in the normal functioning of the endometrium during and after the menstrual cycle. Vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP) are the mostly expressed angiogenic factors, especially, during the process of endometrial degeneration and remodeling. In carcinogenesis, tumor hypoxia-induced factors, through the process of "angiogenic switch", stimulate the production of angiogenic factors, particularly VEGF and MMP...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29030908/epidemiology-of-infertility-in-china-a-population-based-study
#17
Zehong Zhou, Danni Zheng, Hongping Wu, Rong Li, Suxin Xu, Yuefan Kang, Yunxia Cao, Xiujuan Chen, Yimin Zhu, Shuguang Xu, Zi-Jiang Chen, Ben Willem Mol, Jie Qiao
OBJECTIVE: To assess the current prevalence of and risk factors for infertility among couples of reproductive age in China. DESIGN: Population-based cross-sectional study. SETTING: We approached 25,270 couples in 8 provinces/municipalities, of whom 18,571 (response rate 74%, 18,571/25,270) were interviewed. POPULATION: Couples living together and married for more than 1 year, of whom the female spouse was 20-49 years old...
October 14, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29030160/mobile-application-vs-paper-pictorial-blood-assessment-chart-to-track-menses-in-young-women-a-randomized-cross-over-design
#18
Amanda E Jacobson, Sara K Vesely, Fareeda Haamid, Myra Christian-Rancy, Sarah H O'Brien
BACKGROUND: /Objectives: Heavy menstrual bleeding is a common complaint reported by approximately 30% of women. The Pictorial Blood Assessment Chart (PBAC) score is often used to quantify severity of menstrual bleeding. However, the traditional PBAC paper diary may be subject to recall bias and compliance issues, especially in adolescents. We developed a mobile application (app) version of the PBAC score and evaluated patient satisfaction and compliance with app reporting vs paper reporting...
October 10, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29024378/the-cyclocalyx-study-ovulatory-cycle-affects-circulating-compartments-of-the-endothelial-glycocalyx-in-blood
#19
Nikolai Hulde, Nina Rogenhofer, Florian Brettner, Nicole C Eckert, Isabella Götzfried, Thu Nguyen, Judith-I Pagel, Tobias Kammerer, Klaus F Hofmann-Kiefer, Gustav Schelling, Andreas Dendorfer, Markus Rehm, Christian J Thaler
PROBLEM: The endothelial glycocalyx (EGX) plays an important role in vascular integrity. Recently, increased levels of EGX components were detected in the circulating blood of healthy pregnant women and were related to the increased tendency to edema formation during gestation. However, the EGX has not yet been systematically studied in non-pregnant women during ovulatory cycles. METHOD OF STUDY: Serum levels of EGX components syndecan-1, heparan sulfate, and hyaluronan in healthy women (n = 16) at 3 phases of the ovulatory cycle (early follicular phase, at ovulation, and mid-luteal phase) were compared with a control group of healthy men (n = 10)...
October 11, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29022209/therapeutic-doses-of-doxorubicin-induce-premature-senescence-of-human-mesenchymal-stem-cells-derived-from-menstrual-blood-bone-marrow-and-adipose-tissue
#20
Irina Kozhukharova, Victoria Zemelko, Zoya Kovaleva, Larisa Alekseenko, Olga Lyublinskaya, Nikolay Nikolsky
Doxorubicin (Dox) is an effective anticancer drug with known activity against a wide spectrum of malignancies, hematologic malignancies in particular. Despite extensive clinical use, the mechanisms of its side effects and negative action on normal cells remain under study. The aim of this study was to investigate the effect of Dox on cultured human mesenchymal stem cells (MSCs) derived from menstrual blood (eMSCs), bone marrow (BMSCs) and adipose tissue (AMSCs). Dox treatment in high doses decreased the survival of MSCs in a dose-dependent manner...
October 11, 2017: International Journal of Hematology
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