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https://www.readbyqxmd.com/read/29770717/treatment-patterns-and-health-care-resource-utilization-and-costs-in-heavy-menstrual-bleeding-a-japanese-claims-database-analysis
#1
Sayako Akiyama, Erika Tanaka, Olivier Cristeau, Yoshie Onishi, Yutaka Osuga
AIMS: Heavy menstrual bleeding (HMB) is a highly prevalent condition characterized by excessive menstrual blood loss and cramping that interferes with activities of daily life. The aim of our study was to investigate treatment patterns in HMB in Japan, and to assess healthcare resource utilization and costs among women newly diagnosed with the condition. MATERIALS AND METHODS: We retrospectively analysed health insurance data available in the Japan Medical Data Center (JMDC) database on women aged 18-49 years who were newly diagnosed with primary or secondary HMB...
May 17, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29750173/radiotherapy-for-adult-medulloblastoma-evaluation-of-helical-tomotherapy-volumetric-intensity-modulated-arc-therapy-and-three-dimensional-conformal-radiotherapy-and-the-results-of-helical-tomotherapy-therapy
#2
Sun Zong-Wen, Yang Shuang-Yan, Du Feng-Lei, Cheng Xiao-Long, Li Qinglin, Chen Meng-Yuan, Hua Yong-Hong, Jin Ting, Hu Qiao-Ying, Chen Xiao-Zhong, Chen Yuan-Yuan, Chen Ming
Introduction: All adult medulloblastoma (AMB) patients should be treated with craniospinal irradiation (CSI) postoperatively. Because of the long irradiation range, multiple radiation fields must be designed for conventional radiotherapy technology. CSI can be completed in only one session with helical tomotherapy (HT). We evaluated the dose of HT, volumetric intensity modulated arc therapy (VMAT), and three-dimensional conformal radiotherapy (3D-CRT) of AMB and the results of 5 cases of AMB treated with HT...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29742662/patterns-of-von-willebrand-disease-screening-in-girls-and-adolescents-with-heavy-menstrual-bleeding
#3
Amanda E Jacobson, Sara K Vesely, Terah Koch, Janis Campbell, Sarah H OʼBrien
OBJECTIVE: To estimate the frequency of von Willebrand disease screening and factors that affect screening frequency in a national sample of girls and adolescents with heavy menstrual bleeding. METHODS: In this retrospective cohort study, we used a national claims database for privately and publicly insured patients between 2011 and 2013 for girls aged 10-17 years. Diagnostic criteria of heavy menstrual bleeding were the presence of one inpatient or two outpatient International Classification of Diseases, 9th Revision codes for heavy menstrual bleeding...
May 7, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29741107/ovarian-aging-an-ongoing-prospective-community-based-cohort-study-in-middle-aged-chinese-women
#4
X Sun, M Luo, M Ma, R Tang, Y Wang, G Liu, S Lin, R Chen
PURPOSE: This study described the design and development of a cohort study established to investigate the ovarian aging process and its impact on women's health. METHODS: A community-based prospective cohort study of middle-aged Chinese women was initiated in 2005 and is ongoing. Sociodemographic characteristics, menstrual calendars, and medical histories were recorded at baseline and at annual follow-ups. Physical measures, blood sampling, bone status assessment, and body composition evaluation are likewise performed annually...
May 9, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29740283/transplantation-of-human-menstrual-blood-derived-mesenchymal-stem-cells-alleviates-alzheimer-s-disease-like-pathology-in-app-ps1-transgenic-mice
#5
Yongjia Zhao, Xin Chen, Yichen Wu, Yanling Wang, Yifei Li, Charlie Xiang
Extracellular β-amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) are the pathological hallmarks of Alzheimer's disease (AD). Mesenchymal stem cells (MSCs) have shown therapeutic efficacy in many neurodegenerative diseases, including AD. Human menstrual blood-derived stem cells (MenSCs) are a novel source of MSCs advantageous for their higher proliferation rate and because they are easy to obtain without ethical concerns. Although MenSCs have exhibited therapeutic efficacy in some diseases, their effects on AD remain elusive...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29714444/association-of-serum-leptin-with-serum-estradiol-in-relation-to-breast-carcinogenesis-a-comparative-case-control-study-between-pre-and-postmenopausal-women
#6
Syed Danish Haseen Ahmed, Farah Idrees, Muhammad Ahsan, Aziza Khanam, Naheed Sultan, Naheed Akhter
Background/aim: The aims of this study were to observe the interhormonal relationship of serum leptin with serum estradiol and to compare pre- and postmenopausal women for possible implications in breast carcinogenesis. Materials and methods: This comparative case-control study encompasses 175 breast cancer patients and 175 age-, sex-, and BMI- matched healthy controls. For comparison, the subjects were divided into pre- and postmenopausal groups according to their menstrual history. Blood samples were analyzed for serum leptin and serum estradiol by the ELISA method...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29714155/investigating-the-isolation-and-amplification-of-micrornas-for-forensic-body-fluid-identification
#7
Claire L Glynn, Kelsie R O Leary
BACKGROUND: The discovery of forensic DNA typing evolved molecular biology far beyond what could have been expected in terms of its forensic application, and now there exists other developments in molecular biology which are ready for application to forensic challenges. One such challenge is the identification of the body fluid source of stains recovered from evidence items and crime scenes. Currently there are significant efforts in the research field to develop novel methods for the molecular identification of body fluids, with microRNAs (miRNAs) revealing great potential...
April 30, 2018: MicroRNA
https://www.readbyqxmd.com/read/29710691/beta-estradiol-and-ethinylestradiol-enhance-rbc-deformability-dependent-on-their-blood-concentration
#8
Paulo L Farber, Teresa Freitas, Carlota Saldanha, Ana Santos Silva-Herdade
BACKGROUND: Natural and synthetic estrogens seems to have opposite effects on thrombosis and female cardiovascular system, since natural estrogen was supposed to be protective against cardiovascular diseases and synthetic estrogen has been related to thrombosis and cardiovascular diseases. In this work we have investigated if these differences could be related with the effects on those hormones on some hemorheological parameters. OBJECTIVE: The objective of this work was to investigate the hemorheological changes of different concentrations of beta-estradiol and ethinylestradiol, on RBC aggregation and RBC deformability...
April 14, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29706142/prenatal-lead-exposure-in-relation-to-age-at-menarche-results-from-a-longitudinal-study-in-mexico-city
#9
E C Jansen, L Zhou, P X K Song, B N Sánchez, A Mercado, H Hu, M Solano, K E Peterson, M M Tellez-Rojo
Animal and cross-sectional epidemiological studies suggest that prenatal lead exposure is related to delayed menarche, but this has not been confirmed in longitudinal studies. We analyzed this association among 200 girls from Mexico City who were followed since the first trimester of gestation. Maternal blood lead levels were analyzed once during each trimester of pregnancy, and daughters were asked about their first menstrual cycle at a visit between the ages of 9.8 and 18.1 years. We estimated hazard ratios (HRs) and 95% confidence intervals (CI) for probability of menarche over the follow-up period using interval-censored Cox models, comparing those with prenatal blood lead level ⩾5 µg/dl to those with prenatal blood lead <5 µg/dl...
April 30, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29704897/occurrence-of-anembryonic-pregnancy-with-use-of-levonorgestrel-subdermal-implant-jadelle%C3%A2-a-case-report
#10
Jude Moutchia-Suh, Dave-King Moutourou Mouemba, Calypse Asangbe Ngwasiri
BACKGROUND: Progestin-only subdermal implants are one of the most effective contraceptive methods. Anembryonic pregnancy is not reported as a possible outcome in cases of contraceptive failure of these products. We present a rare case of anembryonic pregnancy occurring in a woman with levonorgestrel-releasing implant (JADELLE®). CASE PRESENTATION: A 31-year-old Cameroonian (black African) housewife with a JADELLE® implant for 13 months, consulted at our hospital for a 1-month history of pelvic pain, prolonged menstrual bleeding, and spotting...
April 29, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29692815/n-cadherin-upregulation-promotes-the-neurogenic-differentiation-of-menstrual-blood-derived-endometrial-stem-cells
#11
Yanli Liu, Fen Yang, Shengying Liang, Qing Liu, Sulei Fu, Zhenyu Wang, Ciqing Yang, Juntang Lin
Peripheral nerve injuries are typically caused by either trauma or medical disorders, and recently, stem cell-based therapies have provided a promising treatment approach. Menstrual blood-derived endometrial stem cells (MenSCs) are considered an ideal therapeutic option for peripheral nerve repair due to a noninvasive collection procedure and their high proliferation rate and immunological tolerance. Here, we successfully isolated MenSCs and examined their biological characteristics including their morphology, multipotency, and immunophenotype...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29692669/bacterial-contamination-hypothesis-a-new-concept-in-endometriosis
#12
REVIEW
Khaleque N Khan, Akira Fujishita, Koichi Hiraki, Michio Kitajima, Masahiro Nakashima, Shinji Fushiki, Jo Kitawaki
Background: Endometriosis is a multifactorial disease that mainly affects women of reproductive age. The exact pathogenesis of this disease is still debatable. The role of bacterial endotoxin (lipopolysaccharide, LPS) and Toll-like receptor 4 (TLR4) in endometriosis were investigated and the possible source of endotoxin in the pelvic environment was examined. Methods: The limulus amoebocyte lysate test was used to measure the endotoxin levels in the menstrual fluid and peritoneal fluid and their potential role in the growth of endometriosis was investigated...
April 2018: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29680740/moringa-concanensis-nimmo-ameliorates-hyperglycemia-in-3t3-l1-adipocytes-by-upregulating-ppar-%C3%AE-c-ebp-%C3%AE-via-akt-signaling-pathway-and-stz-induced-diabetic-rats
#13
Brindha Banu Balakrishnan, Kalaivani Krishnasamy, Ki Choon Choi
Moringa concanensis Nimmo is a medicinal plant for treating various human illnesses including menstrual pain, high blood pressure, jaundice, inflammation, pain, fever, sore eyes, and cholesterol in Indian folk medicine. Despite its versatility, its antihyperglycemic mechanism of action (in vitro and in vivo) remains unclear. Therefore, in this study we developed the possible antihyperglycemic mechanism of action in 3T3-L1 cells by evaluating mRNA and protein expression, which are associated with adipogenesis and lipogenesis (insulin sensitizer)...
April 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29678493/analysis-and-validation-of-a-new-extended-method-for-estimating-plasma-free-cortisol-including-neutrophil-elastase-and-competition-from-other-steroids
#14
Johanne Gudmand-Hoeyer, Johnny T Ottesen
A non-linear mechanistic model for the distribution of cortisol in plasma on free and bound forms is proposed. The influence of progesterone, testosterone and neutrophil elastase on the cortisol distribution in the blood is investigated. The activity of neutrophil elastase is directly included in the model with the concentration of elastase and the kinetic constants describing the activity of elastase collected in one single input variable. The model is very sensitive towards this input variable and fits data excellently, when it is allowed to be subject specific...
April 17, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29670382/clinical-outcomes-and-health-care-utilization-pre-and-post-laparoscopic-radiofrequency-ablation-of-symptomatic-fibroids-and-laparoscopic-myomectomy-a-randomized-trial-of-uterine-sparing-techniques-trust-in-canada
#15
Darrien D Rattray, Laura Weins, Lexy C Regush, James M Bowen, Daria O'Reilly, John A Thiel
Objective: The objective of this study was to compare laparoscopic ultrasound-guided radiofrequency ablation of fibroids (Lap-RFA) and laparoscopic myomectomy in terms of 1) health care utilization and 2) serious complication rates. The secondary objectives were comparison of subject responses to validated symptom and quality-of-life questionnaires. We hypothesized that Lap-RFA health care utilization and clinical outcomes would not be worse than those of laparoscopic myomectomy in the aggregate...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29663371/distribution-of-extracellular-matrix-molecules-in-human-uterine-tubes-during-the-menstrual-cycle-a-histological-and-immunohistochemical-analysis
#16
Carlos Godoy-Guzmán, Claudio Nuñez, Pedro Orihuela, Antonio Campos, Víctor Carriel
The uterine tube (UT) is an important and complex organ of the women's reproductive system. In general, the anatomy and basic histology of this organ are well-known. However, the composition and function of the extracellular matrix (ECM) of the UT is still poorly understood. The ECM is a complex supramolecular material produced by cells which is commonly restricted to the basement membrane and interstitial spaces. ECM molecules play not only a structural role, they are also important for cell growth, survival and differentiation in all tissues...
April 16, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29659847/follicle-growth-and-endocrine-dynamics-in-women-with-spontaneous-luteinized-unruptured-follicles-versus-ovulation
#17
S T Bashir, A R Baerwald, M O Gastal, R A Pierson, E L Gastal
STUDY QUESTION: Do growth patterns and endocrine profiles differ between ovulatory follicles (OvFs) and luteinized unruptured follicles (LUFs) in women? SUMMARY ANSWER: Growth rates, diameters and associated endocrine profiles differed between OvFs and LUFs in unstimulated cycles. WHAT IS KNOWN ALREADY: Two-three waves of antral follicles develop during the menstrual cycle in ovulatory women of reproductive age, with the second or third wave terminating in ovulation...
April 6, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29659835/anti-m%C3%A3-llerian-hormone-levels-and-incidence-of-early-natural-menopause-in-a-prospective-study
#18
Elizabeth R Bertone-Johnson, JoAnn E Manson, Alexandra C Purdue-Smithe, Anne Z Steiner, A Heather Eliassen, Susan E Hankinson, Bernard A Rosner, Brian W Whitcomb
STUDY QUESTION: Are anti-Müllerian hormone (AMH) levels assessed in women aged 32-44 associated with risk of incident early natural menopause? SUMMARY ANSWER: We observed strong, significant associations between lower AMH levels and higher risk of early menopause. WHAT IS KNOWN ALREADY: The ability to predict risk early menopause, defined as menopause before age 45, prior to fertility decline would improve options for family planning and cardiovascular disease prevention...
April 5, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29658354/serum-chemerin-level-in-women-with-pcos-and-its-relation-with-the-risk-of-spontaneous-abortion
#19
Xuezhou Yang, Xiaozhen Quan, Yanli Lan, Qipeng Wei, Jinhai Ye, Xiaofang Yin, Zhisong Ji, Hui Xing, Ying Yang
BACKGROUND AND AIM: Insulin resistance (IR) was recognized as a risk factor for the occurrence of abortion in patients with polycystic ovary syndrome (PCOS). Chemerin was an adipokine which could induce IR and associated with reproductive process closely. However, few studies have inquired the relativity between chemerin and the occurrence of abortion in patients with PCOS. The aim of this study was to evaluate the relationship between serum chemerin and the occurrence of abortion in women with PCOS...
April 16, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29656433/antifibrinolytics-for-heavy-menstrual-bleeding
#20
REVIEW
Alison C Bryant-Smith, Anne Lethaby, Cindy Farquhar, Martha Hickey
BACKGROUND: Heavy menstrual bleeding (HMB) is an important physical and social problem for women. Oral treatment for HMB includes antifibrinolytic drugs, which are designed to reduce bleeding by inhibiting clot-dissolving enzymes in the endometrium.Historically, there has been some concern that using the antifibrinolytic tranexamic acid (TXA) for HMB may increase the risk of venous thromboembolic disease. This is an umbrella term for deep venous thrombosis (blood clots in the blood vessels in the legs) and pulmonary emboli (blood clots in the blood vessels in the lungs)...
April 15, 2018: Cochrane Database of Systematic Reviews
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