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https://www.readbyqxmd.com/read/28938558/human-menstrual-blood-derived-mesenchymal-stem-cells-as-a-cellular-vehicle-for-malignant-glioma-gene-therapy
#1
Xiao-Jun Wang, Bing-Yu Xiang, Ya-Hui Ding, Lu Chen, Hai Zou, Xiao-Zhou Mou, Charlie Xiang
Despite many advances in conventional treatment strategies, there is no effective treatment modality for malignant gliomas. Gene therapy may offer a promising option for gliomas and several gene therapy approaches have shown anti-tumor efficiency in previous studies. Mesenchymal stem cell-based gene therapies, in which stem cells are genetically engineered to express therapeutic molecules, have shown tremendous potential because of their innate homing ability. In this study, human menstrual blood-derived MSCs (MenSC), a novel type of multipotential MSCs displays tropism for human malignant glioma when used as a gene delivery vehicle for therapeutics...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937041/evaluation-of-circulating-endometrial-cells-as-a-biomarker-for-endometriosis
#2
Ying Chen, Hong-Lan Zhu, Zhe-Wen Tang, Kuang Hong Neoh, Dong-Fang Ouyang, Heng Cui, Hong-Yan Cheng, Rui-Qiong Ma, Xue Ye, Ray Ps Han, Xiao-Hong Chang
BACKGROUND: Circulating endometrial cells (CECs) have been reported to be present in the peripheral blood of women with endometriosis (EM), providing clear and specific evidence of the presence of ectopic lesions. In this study, we established a method with a high detection rate of CECs, assessed the diagnostic value of CECs for EM and compared with serum CA125, and proposed a hypothesis for the pathogenesis of EM from the new perspective of CECs. METHODS: The participants were enrolled prospectively from October 2015 to July 2016...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28936853/-classics-textual-research-and-using-situation-investigation-of-tibetan-medicine-zha-xun
#3
Yun Cao, Rui Gu, Ming-Ming Zhao, Yu-Ying Ma, Shi-Hong Zhong, Jian Rang, Peng Mi
In this article the classics textual research to the origin of "Zha-xun" was carried out, the ethnobotanical research methods, the origin of visits, key informant interviews, sample collection and textual research were applied in the research. The results showed that the hypothesis of Zha-xun"s origin mainly included "source of mine", "source of feces", "source of monkey menstrual blood" in China. There were "source of fossil", "source of the plant secretion" abroad. The authors had interviewed the villagers at origin, herbalists, Tibetan doctors, herb dealers, foreign scholars for a total of 18 people, and collecting 45 batches medicinal materials...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28930874/the-effectiveness-of-fish-oil-supplementation-in-attenuating-exercise-induced-muscle-damage-in-females-during-mid-follicular-and-mid-luteal-menstrual-phases
#4
Sarah K McKinley-Barnard, Thomas L Andre, Josh J Gann, Paul S Hwang, Darryn S Willoughby
The purpose of this study was to determine if the differences in estrogen levels during the female menstrual cycle and fish oil supplementation would attenuate eccentric exercise-induced muscle damage (EIMD) and delayed onset muscle soreness (DOMS). In a double-blind fashion, 22 physically-active females (20.9 ± 1.4 years, 63.5 ± 9.0 kg, 165.2 ± 7.5 cm) were randomly assigned to ingest either 6 grams of fish oil (n = 11) or placebo (n = 11) daily for 21 days. Participants underwent an eccentric exercise bout of the knee extensors on two occasions during the mid-follicular (MF) and mid-luteal (ML) phases of the 28-day menstrual cycle...
September 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28924270/clinical-efficacy-of-levonorgestrel-and-norethisterone-for-the-treatment-of-chronic-abnormal-uterine-bleeding
#5
Muhammad Nadeem Ashraf, Agha Habib-Ur-Rehman, Zahid Shehzad, Shakir DakheelAllah AlSharari, Ghulam Murtaza
OBJECTIVE: To compare the clinical efficacy of levonorgestrel intrauterine system with oral norethisterone for the treatment of idiopathic chronic abnormal uterine bleeding. METHODS: This cross-sectional study was conducted at Bahawal Victoria Hospital, Jubilee Female Hospital, Civil Hospital and private clinics of consultant gynaecologists in Bahawalpur, Pakistan, from March to August 2014, and comprised patients presenting with abnormal uterine bleeding. The patients were equally and randomly divided into two groups, i...
September 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28913369/changes-in-the-width-of-the-tibiofibular-syndesmosis-related-to-lower-extremity-joint-dynamics-and-neuromuscular-coordination-on-drop-landing-during-the-menstrual-cycle
#6
Michie Okazaki, Masaaki Kaneko, Yukisato Ishida, Norio Murase, Toshihito Katsumura
BACKGROUND: Many injuries of the lower extremities, especially the knee and ankle, occur during sports activity, and the incidence rate is higher in women than in men. HYPOTHESIS: The hypothesis was that phases of the menstrual cycle affect the width of the tibiofibular syndesmosis during drop landing in healthy young women and that such changes at the tibiofibular joint also affect the dynamics and neuromuscular coordination of the lower extremities. STUDY DESIGN: Descriptive laboratory study...
September 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28906379/accessory-ovarian-steroid-cell-tumor-producing-testosterone-and-cortisol-a-case-report
#7
Li Zang, Mingxia Ye, Guoqing Yang, Jinlong Li, Mei Liu, Jin Du, Weijun Gu, Nan Jin, Lijuan Yang, Jianming Ba, Jingtao Dou, Wensheng Fan, Yiming Mu, Yuanguang Meng, Zhaohui Lyu
RATIONALE: An accessory ovary is a rare structure containing normal ovarian tissue, which has a direct or ligamentous connection with a normal and eutopic ovary. PATIENT CONCERNS: In the study, we reported a 46-year-old woman presented with secondary amenorrhea and virilization symptoms for 1 year. DIAGNOSES: Endocrine evaluation revealed slightly elevated serum cortisol, extremely elevated 24-hour urinary-free cortisol and serum testosterone...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28892501/implementation-of-a-study-to-examine-the-persistence-of-ebola-virus-in-the-body-fluids-of-ebola-virus-disease-survivors-in-sierra-leone-methodology-and-lessons-learned
#8
Gibrilla Fadlu Deen, Suzanna L R McDonald, Jaclyn E Marrinan, Foday R Sesay, Elizabeth Ervin, Anna E Thorson, Wenbo Xu, Ute Ströher, Patricia Ongpin, Neetu Abad, Archchun Ariyarajah, Tasneem Malik, Hongtu Liu, Christine Ross, Kara N Durski, Philippe Gaillard, Oliver Morgan, Pierre Formenty, Barbara Knust, Nathalie Broutet, Foday Sahr
BACKGROUND: The 2013-2016 West African Ebola virus disease epidemic was unprecedented in terms of the number of cases and survivors. Prior to this epidemic there was limited data available on the persistence of Ebola virus in survivors' body fluids and the potential risk of transmission, including sexual transmission. METHODOLOGY/PRINCIPAL FINDINGS: Given the urgent need to determine the persistence of Ebola virus in survivors' body fluids, an observational cohort study was designed and implemented during the epidemic response operation in Sierra Leone...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28892490/development-of-risk-reduction-behavioral-counseling-for-ebola-virus-disease-survivors-enrolled-in-the-sierra-leone-ebola-virus-persistence-study-2015-2016
#9
Neetu Abad, Tasneem Malik, Archchun Ariyarajah, Patricia Ongpin, Matthew Hogben, Suzanna L R McDonald, Jaclyn Marrinan, Thomas Massaquoi, Anna Thorson, Elizabeth Ervin, Kyle Bernstein, Christine Ross, William J Liu, Karen Kroeger, Kara N Durski, Nathalie Broutet, Barbara Knust, Gibrilla F Deen
BACKGROUND: During the 2014-2016 West Africa Ebola Virus Disease (EVD) epidemic, the public health community had concerns that sexual transmission of the Ebola virus (EBOV) from EVD survivors was a risk, due to EBOV persistence in body fluids of EVD survivors, particularly semen. The Sierra Leone Ebola Virus Persistence Study was initiated to investigate this risk by assessing EBOV persistence in numerous body fluids of EVD survivors and providing risk reduction counseling based on test results for semen, vaginal fluid, menstrual blood, urine, rectal fluid, sweat, tears, saliva, and breast milk...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28888699/endometrial-ablation-a-review-article
#10
REVIEW
Abimbola Famuyide
The destruction of the endometrium in women with heavy menstrual bleeding has been employed for well over a century and the various techniques of delivering forms of thermal energy have been modified over the years to assure a safe and effective treatment approach. Today, six non-resectoscopic devices are approved for use in the United States in addition to resectoscopic techniques that rely on skillful use of the operative hysteroscope. Regardless of the technique employed, endometrial ablation uniformly reduces menstrual blood loss, improves general and menstrual related quality of life and prevents hysterectomy in four out of five women who undergo the procedure...
September 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28881538/-co-culture-with-endometrial-stromal-cells-promotes-the-differentiation-of-menstrual-blood-derived-mesenchymal-stem-cells-into-endometrial-epithelial-cells
#11
Y S Jiang, H Y Zhu, X Y Jin, C Li, J Li, Y L Zhang, S Y Zhang
Objective: To study the potential of differentiation of menstrual blood-derived mesenchymal stem cells (MenSC) into endometrial epithelial cells (EEC) in vitro. Methods: Endometrial stromal cells (ESC) and MenSC were cultured and identified by certain methods.MenSC were co-cultured with ESC, added 10 ng/ml TGF-β1, 10 ng/ml EGF, 10 ng/ml PDGF-BB and 1×10(-7) mol/L 17-β-estradiol.The expression of cytokeratin, which was marker of EEC, was tested by immunofluorescence in differentiated MenSC. Results: MenSC proliferated quickly in vitro, and showed fusiform shape and clear structure within 10 generations...
September 5, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28875308/physical-social-and-political-inequities-constraining-girls-menstrual-management-at-schools-in-informal-settlements-of-nairobi-kenya
#12
Candace Girod, Anna Ellis, Karen L Andes, Matthew C Freeman, Bethany A Caruso
Access to adequate water and sanitation is limited in informal settlements, contributing to girls' challenges managing menstruation at school, especially when they cannot access materials to absorb menstrual blood and appropriate facilities for hygiene. This study documents differences between girls' experience of menstruation at public schools (where the Kenyan government provides menstrual pads) and private schools (where pads are not provided) in two informal settlements of Nairobi, Kenya. Results showed that supply chains to public schools were not reliable, and equitable pad provision was not assured...
September 5, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28869206/serum-magnesium-and-calcium-levels-in-infertile-women-during-a-cycle-of-reproductive-assistance
#13
Elena Grossi, Sara Castiglioni, Claudia Moscheni, Patrizio Antonazzo, Irene Cetin, Valeria Maria Savasi
Magnesium (Mg) and calcium (Ca) are essential cations for women's preconception health. It is well known that, in blood, the concentration of ionized form of these two cations is temporally altered during menstrual cycle, suggesting a correlation between sex steroid hormones and serum calcium and magnesium levels. Evidence from literature suggests that in assisted reproductive technology increasing estrogens during ovarian hyperstimulation may also modulate serum magnesium and calcium levels. Therefore, we first examined total serum magnesium and calcium levels during follicular phase in a large population of infertile patients who underwent intrauterine insemination (IUI)...
May 1, 2017: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/28856862/gonadotrophin-releasing-hormone-agonist-combined-with-high-intensity-focused-ultrasound-ablation-for-adenomyosis-a-clinical-study
#14
Y Guo, H Duan, J Cheng, Y Zhang
OBJECTIVES: This study was to investigate the clinical efficacy of a gonadotrophin-releasing hormone agonist (GnRH-a) combined with high-intensity focused ultrasound (HIFU) ablation treatment for adenomyosis. DESIGN: A non-randomized prospective study. SETTING: Gynaecological Minimally Invasive Centre in a single hospital. POPULATION: Patients with adenomyosis. METHODS: Seventy-nine patients with adenomyosis were enrolled, including 55 patients in the control group treated with only HIFU and 24 patients in the study group treated with GnRH-a combined with HIFU...
August 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28854716/livebirth-and-utero-placental-insufficiency-in-papio-hamadryas-baboons-with-uterus-angiosome-perfused-by-bilateral-utero-ovarian-microsurgical-anastomoses-alone
#15
B Beran, K Arnolds, M Shockley, K Rivas, M Medina, P F Escobar, A Tzakis, T Falcone, M L Sprague, S Zimberg
STUDY QUESTION: Can the baboon uterus support a gestation to livebirth with an angiosome using microsurgically anastomosed utero-ovarian vessels and lacking uterine arteries and veins? SUMMARY ANSWER: Our angiosome model allows healthy livebirth albeit with risk of fetal growth restriction and stillbirth. WHAT IS KNOWN ALREADY: Uterine transplant can provide livebirth in humans, but requires a living donor to undergo a prolonged laparotomy for hysterectomy...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28840001/bronchial-hyperreactivity-in-perimenstrual-asthma-is-associated-with-increased-th-2-response-in-lower-airways
#16
Szymon Skoczynski, Aleksandra Semik-Orzech, Ewa Sozanska, Wojciech Szanecki, Krzysztof Kołodziejczyk, Igor Radziewicz-Winnicki, Andrzej Witek, Władysław Pierzchała, Adam Barczyk
BACKGROUND: Perimenstrual asthma (PMA) is a commonly observed, usually difficult-to-treat asthma phenotype. The mechanisms underlying this phenomenon remain unexplained. The aim of the study was to assess the degree of airway hyperresponsiveness and its relationship to proinflammatory cytokines concentration in lower airways of PMA compared to non-PMA patients. METHODS: Premenopausal women with regular menstrual cycles diagnosed as: PMA (n=12), non-PMA asthmatics (n=9), and healthy controls (n=10) were prospectively followed for 10 weeks over two consecutive menstrual cycles...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28831309/effect-of-efavirenz-on-endogenous-progesterone-concentrations-and-contraceptive-outcomes-among-ugandan-hiv-infected-women-coadministering-ethinylestradiol-levonorgestrel
#17
Grant Munkwase, Kuteesa R Bisaso, Othman Kakaire, Sarah Nanzigu
This study assessed the effect of efavirenz mid-dose plasma concentrations on mid-luteal endogenous progesterone concentrations and contraceptive outcomes among 49 HIV infected women coadministering ethinylestradiol/levonorgestrel, including 34 HIV positive women on Highly Active Antiretroviral Therapy (HAART) and 15 HAART naïve HIV infected women, purposively selected from Mulago Hospital, Uganda. A blood sample was collected once between days 20 and 22 of each woman's menstrual cycle for measuring endogenous progesterone and efavirenz concentrations by electrochemiluminescence technology and High Performance Liquid Chromatography (HPLC), respectively...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/28826369/literature-review-on-the-role-of-uterine-fibroids-in-endometrial-function
#18
Deborah E Ikhena, Serdar E Bulun
Uterine fibroids are benign uterine smooth muscle tumors that are present in up to 8 out of 10 women by the age of 50. Many of these women experience symptoms such as heavy and irregular menstrual bleeding, early pregnancy loss, and infertility. Traditionally believed to be inert masses, fibroids are now known to influence endometrial function at the molecular level. We present a comprehensive review of published studies on the effect of uterine fibroids on endometrial function. Our goal was to explore the current knowledge about how uterine fibroids interact with the endometrium and how these interactions influence clinical symptoms...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28818563/-lower-lymphocyte-response-in-severe-cases-of-acute-bronchiolitis-due-to-respiratory-syncytial-virus
#19
José Miguel Ramos-Fernández, David Moreno-Pérez, Cristina Antúnez-Fernández, Guillermo Milano-Manso, Ana María Cordón-Martínez, Antonio Urda-Cardona
INTRODUCTION: Acute bronchiolitis (AB) of the infant has a serious outcome in 6-16% of the hospital admitted cases. Its pathogenesis and evolution is related to the response of the T lymphocytes. The objective of the present study is to determine if the lower systemic lymphocytic response is related to a worse outcome of AB in hospitalised infants. PATIENTS AND METHOD: Retrospective observational-analytical study of cases-controls nested in a cohort of patients admitted due to RSV-AB between the period from October 2010 to March 2015...
August 14, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28804211/apparent-cyclic-vaginal-bleeding-in-a-child-factitious-disorder
#20
Ahmet Ucakturk, Figen Gunindi, Murat Aydin
A 20-mo-old girl was brought to our department by her mother because of breast enlargement. She was diagnosed with premature thelarche. One month later, she returned to our hospital with a complaint of vaginal bleeding. During the subsequent 6 mo, her vaginal bleeding recurred every month while her breast development disappeared. We performed laboratory tests and imaging. At the end of 6 mo, we realized that her mother's menstrual bleeding and the patient's blood staining were concurrent. The mother confessed applying her vaginal flow to her daughter's underwear...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
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