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https://www.readbyqxmd.com/read/29793191/development-and-validation-of-a-prediction-model-for-functional-decline-in-older-medical-inpatients
#1
Toshihiko Takada, Shingo Fukuma, Yosuke Yamamoto, Yukio Tsugihashi, Hiroyuki Nagano, Michio Hayashi, Jun Miyashita, Teruhisa Azuma, Shunichi Fukuhara
OBJECTIVE: To prevent functional decline in older inpatients, identification of high-risk patients is crucial. The aim of this study was to develop and validate a prediction model to assess the risk of functional decline in older medical inpatients. METHODS: In this retrospective cohort study, patients ≥65 years admitted acutely to medical wards were included. The healthcare database of 246 acute care hospitals (n = 229,913) was used for derivation, and two acute care hospitals (n = 1767 and 5443, respectively) were used for validation...
May 17, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29793187/stapp-spatiotemporal-analysis-of-plantar-pressure-measurements-using-statistical-parametric-mapping
#2
Brian G Booth, Noël L W Keijsers, Jan Sijbers, Toon Huysmans
BACKGROUND: Pedobarography produces large sets of plantar pressure samples that are routinely subsampled (e.g. using regions of interest) or aggregated (e.g. center of pressure trajectories, peak pressure images) in order to simplify statistical analysis and provide intuitive clinical measures. RESEARCH QUESTION: We hypothesize that these data reductions discard gait information that can be used to differentiate between groups or conditions. METHODS: To test the hypothesis of null information loss, we created an implementation of statistical parametric mapping (SPM) for dynamic plantar pressure datasets (i...
May 3, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29793014/calf-muscle-oxygen-saturation-during-six-minute-walk-test-and-its-relationship-with-walking-impairment-in-symptomatic-peripheral-artery-disease
#3
Aluísio Andrade-Lima, Gabriel G Cucato, Wagner J R Domingues, Antônio H Germano-Soares, Bruno R Cavalcante, Marilia A Correia, Glauco F Saes, Nelson Wolosker, Andrew W Gardner, Antônio E Zerati, Raphael M Ritti-Dias
OBJECTIVE: Impaired microcirculation is associated with poor walking capacity in symptomatic peripheral artery disease (PAD) patients during treadmill test, however, this test does not simulate the efforts of daily walking of these patients. Thus, the aim of the study was to describe the microcirculation responses during six-minute walk test (6MWT) and to analyze the relationship between microcirculation indicators and walking impairment in symptomatic PAD patients. METHODS: Thirty-four patients were included (mean age = 67...
May 21, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29792993/responsiveness-of-the-japanese-orthopaedic-association-back-pain-evaluation-questionnaire-in-lumbar-surgery-and-its-threshold-for-indicating-clinically-important-differences
#4
Takahito Fujimori, Toshitada Miwa, Takenori Oda
BACKGROUND CONTEXT: Introduced in 2007, the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) has been widely used, but its psychometric properties have not been well studied. PURPOSE: To assess the responsiveness and the clinically important differences of JOABPEQ for lumbar surgery. STUDY DESIGN: Prospective study. PATIENT SAMPLE: Two hundreds and three consecutive patients underwent lumbar surgeries between July 2013 and November 2015 in a single hospital...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29792285/associations-between-trunk-postural-control-in-walking-and-unstable-sitting-at-various-levels-of-task-demand
#5
Julian C Acasio, Courtney M Butowicz, Pawel R Golyski, Maury A Nussbaum, Brad D Hendershot
Trunk postural control (TPC) has been investigated in several populations and tasks. Previous work observed targeted training of TPC via isolated trunk control tasks may improve performance in other activities (e.g., walking). However, the nature of this relationship remains unknown. We therefore investigated the relationship between TPC, at both the global (i.e., response to finite perturbations) and local (i.e., resistance to continuous perturbations) levels, during walking and unstable sitting, both at varying levels of task demand...
May 21, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29792064/the-effect-and-importance-of-physical-activity-on-behavioural-and-psychological-symptoms-in-people-with-dementia-a-systematic-mixed-studies-review
#6
Tina Junge, Jonas Ahler, Hans K Knudsen, Hanne K Kristensen
Background People with dementia may benefit from the effect of physical activity on behavioural and psychological symptoms of dementia. Qualitative synthesis of the importance of physical activity might complement and help clarify quantitative findings on this topic. The purpose of this systematic mixed studies review was to evaluate findings from both quantitative and qualitative methods about the effect and importance of physical activity on behavioural and psychological symptoms of dementia in people with dementia...
January 1, 2018: Dementia
https://www.readbyqxmd.com/read/29791803/bacteria-activated-janus-particles-driven-by-chemotaxis
#7
Zihan Huang, Pengyu Chen, Guo-Long Zhu, Ye Yang, Ziyang Xu, Li-Tang Yan
In the development of biocompatible nano/micro-motors for drug and cargo delivery, motile bacteria represent an excellent energy source for biomedical applications. Despite intense research of the fabrication of bacteria-based motors, how to effectively utilize the instinctive responses of bacteria to environmental stimuli in the fabrication process, particularly, chemotaxis, remains an urgent and critical issue. Here, by developing a molecular-dynamics model of bacterial chemotaxis, we present an investigation of the transport of a bacteria-activated Janus particle driven by chemotaxis...
May 23, 2018: ACS Nano
https://www.readbyqxmd.com/read/29791699/a-comparative-effectiveness-study-for-non-operative-treatment-methods-for-knee-osteoarthritis
#8
Frank R Kolisek, Charles Jaggard, Anton Khlopas, Assem A Sultan, Nipun Sodhi, Michael A Mont
A number of non-operative treatment options are commonly prescribed for patients presenting with degenerative osteoarthritis of the knee, where surgery is not yet recommended. However, there is a paucity of studies evaluating the comparative effectiveness of these treatment options to best inform both patients and providers. This study examined the comparative effectiveness of a home exercise program versus bracing or a combination of the two (brace-only, exercise-only, and brace and exercise cohorts) on the following: 1) objective functional measures (quadriceps muscle strength, Self-Paced Walk Test [SPWT], and Timed "Up & Go" [TUG] Test); 2) subjective functional measures (Lower Extremity Function Scale [LEFS] and Health Survey [VR-12] outcomes); 3) pain using Visual Analog Scale [VAS-10]; 4) patient metrics (patient treatment preference, perceptions, and compliance); and 5) progression to total knee arthroplasty (TKA) over a 12-week period...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791628/validation-of-the-falls-efficacy-scale-international-in-a-sample-of-portuguese-elderly
#9
Cristina Maria Alves Marques-Vieira, Luís Manuel Mota de Sousa, Lisete Maria Ribeiro de Sousa, Sílvia Maria Alves Caldeira Berenguer
OBJECTIVE: to translate and adapt Falls Efficacy Scale - International (FES-I). To analyze the psychometric properties of the FES-I Portugal version. METHOD: psychometric study. Sample consisting of 170 elderly people residing in the Autonomous Region of Madeira. A two- part form was used (sociodemographic characterization and FES-I Portugal). The cross-cultural adaptation was performed and the following psychometric properties were evaluated: validity (construct, predictive, and discriminant), reliability (Cronbach's alpha), and inter-rater reliability...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29791503/-18f-fdg-and-18f-flt-pet-for-the-evaluation-of-response-to-neo-adjuvant-chemotherapy-in-a-model-of-triple-negative-breast-cancer
#10
Isabella Raccagni, Sara Belloli, Silvia Valtorta, Alessandro Stefano, Luca Presotto, Claudio Pascali, Anna Bogni, Monica Tortoreto, Nadia Zaffaroni, Maria Grazia Daidone, Giorgio Russo, Emilio Bombardieri, Rosa Maria Moresco
RATIONALE: Pathological response to neo-adjuvant chemotherapy (NAC) represents a commonly used predictor of survival in triple negative breast cancer (TNBC) and the need to identify markers that predict response to NAC is constantly increasing. Aim of this study was to evaluate the potential usefulness of PET imaging with [18F]FDG and [18F]FLT for the discrimination of TNBC responders to Paclitaxel (PTX) therapy compared to the response assessed by an adapted Response Evaluation Criteria In Solid Tumors (RECIST) criteria based on tumor volume (Tumor Volume Response)...
2018: PloS One
https://www.readbyqxmd.com/read/29791456/multi-species-suppression-of-herbivores-through-consumptive-and-non-consumptive-effects
#11
Kathryn S Ingerslew, Deborah L Finke
Most studies investigating the importance of non-consumptive interactions for herbivore suppression focus on pairwise interactions between one predator and one prey, ignoring any community context. Further, the potential for non-consumptive interactions to arise between herbivores and non-enemy organisms is commonly overlooked. We investigated the relative contributions of consumptive and non-consumptive effects to aphid suppression by a wasp assemblage containing both enemies and non-enemies. We examined the suppression of two aphid species with different defensive strategies, pea aphids (Acyrthosiphon pisum), which drop from their host plant to the ground, and green peach aphids (Myzus persicae), which remain on the plant and merely walk away...
2018: PloS One
https://www.readbyqxmd.com/read/29790572/-selective-dorsal-rhizotomy-a-review-of-the-literature-on-this-technique-for-the-treatment-of-spasticity-in-infantile-cerebral-palsy
#12
REVIEW
M Garriz-Luis, R Sanchez-Carpintero, M Alegre, S Tejada
INTRODUCTION: Infantile cerebral palsy is a well-known condition, the prevalence of which has varied only slightly over the years. The most common subtype is spastic diplegia, and spasticity is the most disabling symptom. Its treatment involves a multidisciplinary intervention that includes rehabilitation, the use of drugs, and orthopaedic and nervous system surgery, where selective dorsal rhizotomy is a prominent procedure. AIM: To present a thorough review of the use, indication and long-term consequences of selective dorsal rhizotomy...
June 1, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29790009/a-new-model-of-the-spinal-locomotor-networks-of-a-salamander-and-its-properties
#13
Qiang Liu, Huizhen Yang, Jinxue Zhang, Jingzhuo Wang
A salamander is an ideal animal for studying the spinal locomotor network mechanism of vertebrates from an evolutionary perspective since it represents the transition from an aquatic to a terrestrial animal. However, little is known about the spinal locomotor network of a salamander. A spinal locomotor network model is a useful tool for exploring the working mechanism of the spinal networks of salamanders. A new spinal locomotor network model for a salamander is built for a three-dimensional (3D) biomechanical model of the salamander using a novel locomotion-controlled neural network model...
May 22, 2018: Biological Cybernetics
https://www.readbyqxmd.com/read/29789969/identification-of-risk-factors-for-toxicity-in-patients-with-hormone-receptor-positive-advanced-breast-cancer-treated-with-bevacizumab-plus-letrozole-a-calgb-40503-alliance-correlative-study
#14
Daneng Li, Linda M McCall, Olwen M Hahn, Clifford A Hudis, Harvey J Cohen, Hyman B Muss, Aminah Jatoi, Jacqueline M Lafky, Karla V Ballman, Eric P Winer, Debu Tripathy, Bryan Schneider, William Barry, Maura N Dickler, Arti Hurria
BACKGROUND: In hormone receptor-positive advanced breast cancer, a progression-free survival benefit was reported with addition of bevacizumab to first-line letrozole. However, increased toxicity was observed. We hypothesized that functional age measures could be used to identify patients at risk for toxicity while receiving letrozole plus bevacizumab for hormone receptor-positive advanced breast cancer. METHODS: CALGB 40503 was a phase III trial that enrolled patients with hormone receptor-positive advanced breast cancer randomized to letrozole with or without bevacizumab...
May 22, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29789413/best-protocol-for-the-sit-to-stand-test-in-subjects-with-copd
#15
Andrea A Morita, Gianna W Bisca, Felipe V C Machado, Nidia A Hernandes, Fabio Pitta, Vanessa S Probst
BACKGROUND: Different protocols for the sit-to-stand test (STS) are available for assessing functional capacity in COPD. We sought to correlate each protocol of the STS (ie, the 5-repetition [5-rep STS], the 30-s STS, and the 1-min STS) with clinical outcomes in subjects with COPD. We also aimed to compare the 3 protocols of the STS, to verify their association and agreement, and to verify whether the 3 protocols are able to predict functional exercise capacity and physical activity in daily life (PADL)...
May 22, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29789347/scaling-of-avian-bipedal-locomotion-reveals-independent-effects-of-body-mass-and-leg-posture-on-gait
#16
REVIEW
Monica A Daley, Aleksandra Birn-Jeffery
Birds provide an interesting opportunity to study the relationships between body size, limb morphology and bipedal locomotor function. Birds are ecologically diverse and span a large range of body size and limb proportions, yet all use their hindlimbs for bipedal terrestrial locomotion, for at least some part of their life history. Here, we review the scaling of avian striding bipedal gaits to explore how body mass and leg morphology influence walking and running. We collate literature data from 21 species, spanning a 2500× range in body mass from painted quail to ostriches...
May 22, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29788983/role-of-pulmonary-hemodynamics-in-determining-6-minute-walk-test-result-in-atrial-septal-defect-an-observational-study
#17
Supomo Supomo, Handy Darmawan, Adika Zhulhi Arjana
BACKGROUND: The presence of altered pulmonary hemodynamics in adult patients with atrial septal defect (ASD) is common. However, there are no observational studies which evaluate the impact of altered pulmonary hemodynamics on the 6-min walk test (6MWT) result. This study aimed to investigate the role of pulmonary hemodynamics in determining 6MWT result of patients with ASD. METHOD: Forty-six consecutive adult patients with ASD were included in this study. Right heart catheterization was performed to obtain the pulmonary hemodynamics profile...
May 22, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29788503/visual-analogue-scales-for-interstitial-lung-disease-a-prospective-validation-study
#18
Helen Yates, Huzaifa I Adamali, Nick Maskell, Shaney Barratt, Charles Sharp
Rationale: Visual analogue scales (VAS) are simple symptom assessment tools which have not been validated in interstitial lung disease (ILD). Simple measures of ILD disease burden would be valuable for non-specialist clinicians monitoring disease away from ILD specialist centres. Objective: To validate VAS to assess change in dyspnoea, cough and fatigue in ILD, and to define the minimal clinically important difference (MCID) for change in these. Methods: 64 patients with ILD completed VAS for dyspnoea, cough and fatigue...
May 16, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29788192/initial-assessment-of-the-risk-assessment-and-prediction-tool-in-a-heterogeneous-neurosurgical-patient-population
#19
Matthew Piazza, Nikhil Sharma, Benjamin Osiemo, Scott McClintock, Emily Missimer, Diana Gardiner, Eileen Maloney, Danielle Callahan, J Lachlan Smith, William Welch, James Schuster, M Sean Grady, Neil R Malhotra
BACKGROUND: Bundled care payments are increasingly being explored for neurosurgical interventions. In this setting, skilled nursing facility (SNF) is less desirable from a cost perspective than discharge to home, underscoring the need for better preoperative prediction of postoperative disposition. OBJECTIVE: To assess the capability of the Risk Assessment and Prediction Tool (RAPT) and other preoperative variables to determine expected disposition prior to surgery in a heterogeneous neurosurgical cohort, through observational study...
May 21, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29787694/gait-alterations-in-femoroacetabular-impingement-syndrome-differ-by-sex
#20
Cara L Lewis, Anne Khuu, Kari L Loverro
Study Design Laboratory study, case-control design. Background Femoroacetabular impingement (FAI) syndrome may affect gait kinematics differently between males and females. Objectives Investigate if individuals with FAI syndrome have different hip and pelvic motion during gait, at their preferred speed and a prescribed speed, compared to individuals of the same sex without pain. Methods Eleven males and 10 females with FAI syndrome and 19 males and 22 females without hip pain participated. Groups were not different in age, body mass index, or activity score...
May 22, 2018: Journal of Orthopaedic and Sports Physical Therapy
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