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Seyed Mohammad Taghdisi, Noor Mohammad Danesh, Mohammad Ramezani, Ahmad Sarreshtehdar Emrani, Khalil Abnous
Zearalenone (ZEN) toxicity is a significant risk for human beings. Thus, it is of high importance to develop sensitive, precise and inexpensive analytical methods for ZEN detection, especially in human serum. Here, a colorimetric aptasensor is presented for determination of ZEN based on nontarget-induced aptamer walker, catalytic reaction of gold nanoparticles (AuNPs), exonuclease III (Exo III) as signal amplifier and 4-nitrophenol as colorimetric agent. Low amount of ZEN requirement and signal amplification are some of the distinct advantages of the proposed aptasensor...
March 22, 2018: ACS Applied Materials & Interfaces
Sijie Tan, Ping Du, Wanting Zhao, Jiaqi Pang, Jianxiong Wang
The purpose of this study was to investigate the pleiotropic effects of 12 weeks of supervised exercise training at maximal fat oxidation (FATmax) intensity on body composition, lipid profile, glycemic control, insulin sensitivity and serum adipokine levels in older women with type 2 diabetes. Thirty-one women with type 2 diabetes, aged 60 to 69 years, were randomly allocated into exercise and control groups. Body composition, lipid profile, blood glucose, insulin resistance and serum leptin and adiponectin concentrations were measured before and after the intervention...
March 21, 2018: International Journal of Sports Medicine
Vikas Pathak, Robert Aris, Brian C Jensen, Wei Huang, Hubert James Ford
BACKGROUND: Plasma pro-BNP (brain natriuretic peptide) levels are often elevated in response to right ventricular (RV) volume and pressure overload, parameters potentially affected by exercise. Plasma pro-BNP levels change in association with long-term changes in pulmonary hemodynamics, thereby serving as a potential biomarker in pulmonary arterial hypertension (PAH). The 6-min Walk Test (6MWT) and pro-BNP level are often checked in a single office visit. There is no universal standard for measuring Pro-BNP levels relative to the timing of the 6MWT...
March 21, 2018: Lung
Bhavin Mahendrabhai Patel, Nirav Vaghela, Deepak Ganjiwale
Background and Objective: The objective of this study is to assess the walking ability of a stroke patient using knee gaiter and suspended walker. Methodology: Thirty participants with first acute stroke within first 3 months with the mean age of 55.73 years participated and were allocated randomly into two groups. Participants were taken from Inpatient Department of Medicine of Shree Krishna Hospital, Karamsad and Physiotherapy Department of Shree Krishna Hospital, Karamsad...
October 2017: Journal of Family Medicine and Primary Care
Francesca Sylos-Labini, Andrea d'Avella, Francesco Lacquaniti, Yury Ivanenko
Handholding can naturally occur between two walkers. When people walk side-by-side, either with or without hand contact, they often synchronize their steps. However, despite the importance of haptic interaction in general and the natural use of hand contact between humans during walking, few studies have investigated forces arising from physical interactions. Eight pairs of adult subjects participated in this study. They walked on side-by-side treadmills at 4 km/h independently and with hand contact. Only hand contact-related sensory information was available for unintentional synchronization, while visual and auditory communication was obstructed...
2018: Frontiers in Physiology
Zhi Gang Lan, Seidu A Richard, Jin Li, Chaohua Yang
Introduction: Nonprojectile penetrating skull base injuries as a result of falls have rarely been confronted in normal neurosurgery although a few nonmissile injuries have been reported. These kinds of injuries represent a life-threatening emergency. Case presentation: We present an unusual case of a 25-year-old male construction worker who suffered an accidental penetrating skull base injury when he fell on a metal rod while he was walking on a 2-meter-high platform...
2018: International Medical Case Reports Journal
Signe B Bentsen, Christine Miaskowski, Bruce A Cooper, Vivi L Christensen, Anne H Henriksen, Are M Holm, Tone Rustøen
Background: Few studies have examined changes in the pain experience of patients with COPD and predictors of pain in these patients. Objectives: The objectives of the study were to examine whether distinct groups of COPD patients could be identified based on changes in the occurrence and severity of pain over 12 months and to evaluate whether these groups differed on demographic, clinical, and pain characteristics, and health-related quality of life (HRQoL). Patients and methods: A longitudinal study of 267 COPD patients with very severe COPD was conducted...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Hanneke E Borst, Gillian S Townend, Mirjam van Eck, Eric Smeets, Mariëlle van den Berg, Aleid Laan, Leopold M G Curfs
This study aimed to determine whether there is a relationship between abnormal foot position and standing and walking ability in individuals with Rett syndrome (RTT), a rare neurological condition primarily affecting females, often accompanied by impaired gross motor function and musculoskeletal deformities. Through means of an online survey, physiotherapists were asked to share information about their work and experience with individuals with RTT. They were asked about their clients' scores on the Rett Syndrome Gross Motor Scale and measures of their foot deformity, passive range of motion of dorsiflexion of the foot, use of supportive footwear, pressure load on the foot, and symmetry in weight bearing...
2018: Journal of Developmental and Physical Disabilities
Linard Filli, Tabea Sutter, Christopher S Easthope, Tim Killeen, Christian Meyer, Katja Reuter, Lilla Lörincz, Marc Bolliger, Michael Weller, Armin Curt, Dominik Straumann, Michael Linnebank, Björn Zörner
Gait dysfunction is a common and relevant symptom in multiple sclerosis (MS). This study aimed to profile gait pathology in gait-impaired patients with MS using comprehensive 3D gait analysis and clinical walking tests. Thirty-seven patients with MS walked on the treadmill at their individual, sustainable speed while 20 healthy control subjects walked at all the different patient's paces, allowing for comparisons independent of walking velocity. Kinematic analysis revealed pronounced restrictions in knee and ankle joint excursion, increased gait variability and asymmetry along with impaired dynamic stability in patients...
March 21, 2018: Scientific Reports
Sonya Allin, John Shepherd, Jennifer Tomasone, Sarah Munce, Gary Linassi, Saima Noreen Hossain, Susan Jaglal
BACKGROUND: Rehospitalization rates resulting from secondary conditions in persons with spinal cord injuries (SCI) are high. Self-management programs for many chronic conditions have been associated with decreases in hospital readmissions. However, in the SCI community, evidence suggests that satisfaction with traditional self-management programs is low. Users with SCI have indicated preference for programs that are online (rather than in-person), that target SCI-specific concerns, and are led by peers with SCI...
March 21, 2018: JMIR Rehabilitation and Assistive Technologies
Shinichi Iwasaki, Chisato Fujimoto, Naoya Egami, Makoto Kinoshita, Fumiharu Togo, Yoshiharu Yamamoto, Tatsuya Yamasoba
BACKGROUND: Galvanic vestibular stimulation delivered as zero-mean current noise (noisy GVS) has been shown to improve static and dynamic postural stability probably by enhancing vestibular information. OBJECTIVE: /Hypothesis: To examine the effect of an imperceptible level of noisy GVS on dynamic locomotion in normal subjects as well as in patients with bilateral vestibulopathy. METHODS: Walking performance of 19 healthy subjects and 12 patients with bilateral vestibulopathy at their preferred speed was examined during application of noisy GVS with an amplitude ranging from 0 to 1000 μA...
March 10, 2018: Brain Stimulation
Louise Foley, Dorothea Dumuid, Andrew J Atkin, Timothy Olds, David Ogilvie
BACKGROUND: Active travel (walking or cycling for transport) is associated with favourable health outcomes in adults. However, little is known about the concurrent patterns of health behaviour associated with active travel. We used compositional data analysis to explore differences in how people doing some active travel used their time compared to those doing no active travel, incorporating physical activity, sedentary behaviour and sleep. METHODS: We analysed cross-sectional data from the 2014/15 United Kingdom Harmonised European Time Use Survey...
March 21, 2018: International Journal of Behavioral Nutrition and Physical Activity
Rinat O Esenaliev, Irene Y Petrov, Yuriy Petrov, Jutatip Guptarak, Deborah R Boone, Emanuele Mocciaro, Harris Weisz, Margaret O Parsley, Stacy L Sell, Helen L Hellmich, Jonathan M Ford, Connor Pogue, Douglas DeWitt, Donald S Prough, Maria Adelaide Micci
We have developed a novel, non-invasive Nano-Pulsed Laser Therapy (NPLT) system that combines the benefits of near-infrared laser light (808 nm) and ultrasound (optoacoustic) waves, which are generated with each short laser pulse within the tissue. We tested NPLT in a rat model of blast-induced neurotrauma to determine whether transcranial application of NPLT provides neuroprotective effects. The laser pulses were applied on the intact rat head one hour after injury using a specially developed fiber-optic system...
March 21, 2018: Journal of Neurotrauma
Anna-Laura Kretz, Silvia von Karstedt, Andreas Hillenbrand, Doris Henne-Bruns, Uwe Knippschild, Anna Trauzold, Johannes Lemke
Despite recent advances in oncology, diagnosis, and therapy, treatment of pancreatic ductal adenocarcinoma (PDAC) is still exceedingly challenging. PDAC remains the fourth leading cause of cancer-related deaths worldwide. Poor prognosis is due to the aggressive growth behavior with early invasion and distant metastasis, chemoresistance, and a current lack of adequate screening methods for early detection. Consequently, novel therapeutic approaches are urgently needed. Many hopes for cancer treatment have been placed in the death ligand tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) since it was reported to induce apoptosis selectively in tumor cells in vitro and in vivo...
March 18, 2018: Cancers
Jacob Callesen, Davide Cattaneo, John Brincks, Ulrik Dalgas
INTRODUCTION: Multiple sclerosis (MS) is characterized by a demyelination that results in reduced conductivity in the somatosensory nervous system, decreased muscle strength, vestibular alteration, and severe fatigue. Progressive resistance training (PRT) has proven to be a promising intervention showing a positive effect on muscle strength. Another promising intervention frequently used in neuro-rehabilitation is task specific training where also Balance and Motor Control Training (BMCT) are incorporated...
2018: NeuroRehabilitation
Yoshino Terui, Eriko Suto, Yohei Konno, Kouun Kubota, Masahiro Iwakura, Mizuki Satou, Shioto Nitta, Kouichi Hasegawa, Masahiro Satake, Takanobu Shioya
OBJECTIVES: The purpose of this study was to confirm the intra-rater reliability and absolute reliability of Lissajous Index (LI) in evaluating the symmetry of trunk movement during gait in patients with stroke and to examine the relation between LI and body function in patients with stroke. METHODS: Twenty-one healthy subjects (11 males and 10 females, age 63.3±2.0 yrs) and 45 patients with stroke (33 males and 12 females, age 58.7±13.4 yrs) were included in the study...
2018: NeuroRehabilitation
D Collado-Mateo, P R Olivares, J C Adsuar, N Gusi
BACKGROUND: The prevalence of sexual problems is very high among women with fibromyalgia. OBJECTIVE: To evaluate the prevalence of sexual problems in women with FM and the potential association among physical activity, quality of life and sexual function. We aimed to contribute in the understanding of the relationships between sexual function and the symptoms of FM. METHODS: The sample of this cross-sectional study was comprised by 113 women with FM and 116 age-matched women without FM...
March 9, 2018: Journal of Back and Musculoskeletal Rehabilitation
Paula Ribeiro Mesquita, Silvia Gonçalves Ricci Neri, Ricardo M Lima, Felipe P Carpes, Ana Cristina de David
BACKGROUND: Obesity is associated with higher foot loading during walking. The impact of this condition on running, however, has yet to be elucidated. RESEARCH QUESTION: The purpose of this study was to examine the association between childhood obesity and plantar pressure distribution during running. METHODS: Forty-two volunteers aged 5-10 years took part in this cross-sectional study. Body mass index (BMI) was assessed for obesity classification...
March 14, 2018: Gait & Posture
Elaine Cristina de Campos, Fabiana Sobral Peixoto-Souza, Viviane Cristina Alves, Renata Basso-Vanelli, Marcela Barbalho-Moulim, Rafael Melillo Laurino-Neto, Dirceu Costa
OBJECTIVE: To determine whether weight loss in women with morbid obesity subjected to bariatric surgery alters lung function, respiratory muscle strength, functional capacity and the level of habitual physical activity and to investigate the relationship between these variables and changes in both body composition and anthropometrics. METHODS: Twenty-four women with morbid obesity were evaluated with regard to lung function, respiratory muscle strength, functional capacity, body composition, anthropometrics and the level of habitual physical activity two weeks prior to and six months after bariatric surgery...
March 15, 2018: Clinics
Tony Lin-Wei Chen, Duo Wai-Chi Wong, Zhi Xu, Qitao Tan, Yan Wang, Ameersing Luximon, Ming Zhang
Flip-flops may change walking gait pattern, increase muscle activity and joint loading, and predispose wearers to foot problems, despite that quantitative evidence is scarce. The purpose of this study was to examine the lower limb muscle co-contraction and joint contact force in flip-flops gait, and compare with those of barefoot and sports shoes walking. Ten healthy males were instructed to perform over-ground walking at self-selected speed under three footwear conditions: 1) barefoot, 2) sports shoes, and 3) thong-type flip-flops...
2018: PloS One
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