Shabir Hassan, Zahra Rezaei, Eder Luna, Dilara Yilmaz-Aykut, Myung Chul Lee, Ana Marie Perea, Anurag Jamaiyar, Nicole Bassous, Minoru Hirano, Fatima Mumtaza Tourk, Cholong Choi, Malin Becker, Iman Yazdi, Kai Fan, Alan Eduardo Avila-Ramirez, David Ge, Reza Abdi, Sudeshna Fisch, Jeroen Leijten, Mark W Feinberg, Biman B Mandal, Ronglih Liao, Su Ryon Shin
Myocardial infarction (MI) is a significant cardiovascular disease that restricts blood flow, resulting in massive cell death and leading to stiff and noncontractile fibrotic scar tissue formation. Recently, sustained oxygen release in the MI area has shown regeneration ability; however, improving its therapeutic efficiency for regenerative medicine remains challenging. Here, a combinatorial strategy for cardiac repair by developing cardioprotective and oxygenating hybrid hydrogels that locally sustain the release of stromal cell-derived factor-1 alpha (SDF) and oxygen for simultaneous activation of neovascularization at the infarct area is presented...
May 11, 2024: Small