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https://www.readbyqxmd.com/read/28324974/altered-viscoelastic-properties-of-stroke-affected-muscles-estimated-using-ultrasound-shear-waves-preliminary-data
#1
Ghulam Rasool, Allison B Wang, William Z Rymer, Sabrina S M Lee
As a result of a brain injury such as stroke, the skeletal muscles may undergo numerous structural and functional alterations. These abnormal changes are linked to muscle weakness, joint contracture, and abnormal muscle tone and eventually, result in motor impairment. A subset of these alterations affects passive muscle stiffness, i.e., viscoelastic properties. However, in vivo estimation of changes in viscoelastic properties is a challenging task. Here, we used the shear wave velocity, estimated through ultrasound SuperSonic imaging (SSI), as a surrogate for viscoelastic properties...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28323639/the-effect-of-boundary-slippage-and-nonlinear-rheological-response-on-flow-of-nanoconfined-water
#2
Amandeep Sekhon, V J Ajith, Shivprasad Vitthal Patil
The flow of water confined to nanometer-sized pores is central to a wide range of subjects from biology to nanofluidic devices. Despite its importance, a clear picture about nanoscale fluid dynamics is yet to emerge. Here we measured dissipation in less than 20 nm thick water films and it was found to decrease for both wetting and non-wetting confining surfaces. The fitting of Carreau-Yasuda model of shear thinning to our measurements implies that flow is non-Newtonian and for wetting surfaces the no-slip boundary condition is valid...
March 21, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28319734/novel-mechanical-impact-simulator-designed-to-generate-clinically-relevant-anterior-cruciate-ligament-ruptures
#3
Nathaniel A Bates, Nathan D Schilaty, Christopher V Nagelli, Aaron J Krych, Timothy E Hewett
BACKGROUND: Over 250,000 anterior cruciate ligament ruptures occur each year; therefore, it is important to understand the underlying mechanisms of these injuries. The objective of the current investigation was to develop and analyze an impact test device that consistently produces anterior cruciate ligament failure in a clinically relevant manner. METHOD: A mechanical impact simulator was developed to simulate the ground reaction force impulse generated from landing in a physiologic and clinically relevant manner...
March 10, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28319367/structural-stability-from-crystallographic-shear-in-tio2-nb2o5-phases-cation-ordering-and-lithiation-behavior-of-tinb24o62
#4
Kent J Griffith, Anatoliy Senyshyn, Clare P Grey
The host structure and reversible lithium insertion and extraction of an intercalation compound, TiNb24O62, are described. Neutron diffraction, applied for the first time to TiNb24O62, allowed an accurate refinement of the complex block superstructure, particularly with respect to the oxygen sublattice. Analysis of the transition-metal sites revealed significant cation ordering in the mixed-metal oxide. Electrochemical analysis demonstrated highly reversible lithium intercalation with ca. 190 mA·h·g(-1) after 100 cycles (C/10 rate, 3 months)...
March 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28318376/advances-in-on-chip-vascularization
#5
Kristina Haase, Roger D Kamm
Microfluidics is invaluable for studying microvasculature, development of organ-on-chip models and engineering microtissues. Microfluidic design can cleverly control geometry, biochemical gradients and mechanical stimuli, such as shear and interstitial flow, to more closely mimic in vivo conditions. In vitro vascular networks are generated by two distinct approaches: via endothelial-lined patterned channels, or by self-assembled networks. Each system has its own benefits and is amenable to the study of angiogenesis, vasculogenesis and cancer metastasis...
March 20, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28317863/dynamic-monitoring-of-membrane-nanotubes-formation-induced-by-vaccinia-virus-on-a-high-throughput-microfluidic-chip
#6
Min Xiao, Na Xu, Cheng Wang, Dai-Wen Pang, Zhi-Ling Zhang
Membrane nanotubes (MNTs) are physical connections for intercellular communication and induced by various viruses. However, the formation of vaccinia virus (VACV)-induced MNTs has never been studied. In this report, VACV-induced MNTs formation process was monitored on a microfluidic chip equipped with a series of side chambers, which protected MNTs from fluidic shear stress. MNTs were formed between susceptible cells and be facilitated by VACV infection through three patterns. The formed MNTs varied with cell migration and virus concentration...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28317839/polymeric-mechanical-amplifiers-of-immune-cytokine-mediated-apoptosis
#7
Michael J Mitchell, Jamie Webster, Amanda Chung, Pedro P G Guimarães, Omar F Khan, Robert Langer
Physical forces affect tumour growth, progression and metastasis. Here, we develop polymeric mechanical amplifiers that exploit in vitro and in vivo physical forces to increase immune cytokine-mediated tumour cell apoptosis. Mechanical amplifiers, consisting of biodegradable polymeric particles tethered to the tumour cell surface via polyethylene glycol linkers, increase the apoptotic effect of an immune cytokine on tumour cells under fluid shear exposure by as much as 50% compared with treatment under static conditions...
March 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28317663/mixed-polymeric-systems-new-ophthalmic-viscosurgical-device-created-by-mixing-commercially-available-devices
#8
Daniele Tognetto, Paolo Cecchini, Rossella D'Aloisio, Romano Lapasin
PURPOSE: To evaluate the rheological properties of mixtures of different commercially available ophthalmic viscosurgical devices (OVDs) containing sodium hyaluronate and chondroitin sulfate. SETTING: Eye Clinic, University of Trieste, Trieste, Italy. DESIGN: Laboratory study. METHODS: Blends were obtained combining a superviscous cohesive OVD (Healon GV [sodium hyaluronate 1%]) and a medium-viscosity dispersive OVD (Viscoat [sodium hyaluronate 3...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28317607/nutritional-aspects-of-dysphagia-management
#9
C Gallegos, E Brito-de la Fuente, P Clavé, A Costa, G Assegehegn
This chapter describes the nutritional aspects of dysphagia management by starting with the definition of these two conditions (dysphagia and malnutrition) that share three main clinical characteristics: (a) their prevalence is very high, (b) they can lead to severe complications, and (c) they are frequently underrecognized and neglected conditions. From an anatomical standpoint, dysphagia can result from oropharyngeal and/or esophageal causes; from a pathophysiological perspective, dysphagia can be caused by organic or structural diseases (either benign or malignant) or diseases causing impaired physiology (mainly motility and/or perception disorders)...
2017: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/28317480/novel-insights-into-complex-cardiovascular-pathologies-using-4d-flow-analysis-by-cardiovascular-magnetic-resonance-imaging
#10
Adam James Lewandowski, Betty Raman, Rajarshi Banerjee, Matteo Milanesi
BACKGROUND: It is essential that we are able to assess variations in blood flow in order to fully understand cardiovascular function in disease pathologies and for identification of individuals at long-term risk of cardiovascular disease development. Qualitative and quantitative assessments of blood flow by imaging modalities have been limited, and much of the accurate quantification has relied on invasive measures. METHODS: This review discusses how four-dimensional velocity cardiovascular magnetic resonance (4D flow CMR) offers increasing potential for the non-invasive assessment of blood flow in the heart and major blood vessels such as the aorta...
March 17, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28317383/design-rules-for-enhanced-interfacial-shear-response-in-functionalized-carbon-fiber-epoxy-composites
#11
Baris Demir, Luke Christian Henderson, Tiffany R Walsh
Carbon-fiber reinforced composites are ideal light-weighting candidates to replace traditional engineering materials. The mechanical performance of these composites results from a complex interplay of influences operating over several length- and time-scales. The mechanical performance may therefore be limited by many factors, one of which being the modest interfacial adhesion between the carbon fiber and the polymer. Surface chemical modification of the fiber, via surface grafting of molecules, is one possible strategy to enhance interactions across the fiber-polymer interface...
March 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28317350/-effects-of-dentin-demineralization-and-bond-strength-properties-of-bioactive-glass-containing-resin-adhesive
#12
Wang Yu, Gong Ling, Ji Yan, Zheng Lichun, Chen Song
OBJECTIVE: This study investigated the shear bond strength and the ability of resin adhesive containing different amounts of bioactive glass (BG) to prevent dentin demineralization. METHODS: BG bonds at 30%, 40%, and 50% concentrations comprised a mixture of coupling agents modifying BG and Single Bond 2. Forty permanent premolars extracted for orthodontic treatment were randomly divided into four groups, namely, control group (BG-free), 30% BG group, 40% BG group, and 50% BG group...
August 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28316256/investigation-on-the-compatibility-of-xanthan-gum-and-calcium-polysulfide-and-the-rheological-properties-of-xg-solutions
#13
Dengfeng Liu, Liming Ren, Chunyu Wen, Jun Dong
The application of shear thinning xanthan gum (XG) solutions as the delivery media can solve the bypassing problem induced by heterogeneity, especially when low permeable zones in aquifer are present. A series of experiments were carried out to investigate the compatibility of XG and calcium polysulfide (CPS) aiming at chromium contamination in groundwater. In addition, rheological properties of XG solutions under subsurface conditions related to delivery were studied. Results indicated that: (1) the presence of XG could slow down reduction of hexavalent chromium by CPS, and the reaction fitted well with the second order kinetics...
March 18, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28316038/the-impact-of-the-aortic-valve-impairment-on-the-distant-coronary-arteries-hemodynamics-a-fluid-structure-interaction-study
#14
Hossein Mohammadi, Raymond Cartier, Rosaire Mongrain
Atherosclerosis is still the leading cause of death in the developed world. Although its initiation and progression is a complex multifactorial process, it is well known that blood flow-induced wall shear stress (WSS) is an important factor involved in early atherosclerotic plaque initiation. In recent clinical studies, it was established that the regional pathologies of the aortic valve can be involved in the formation of atherosclerotic plaques. However, the impact of hemodynamic effects is not yet fully elucidated for disease initiation and progression...
March 18, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28315084/multiple-lipid-nanoparticles-mln-a-new-generation-of-lipid-nanoparticles-for-drug-delivery-systems-lamivudine-mln-experimental-design
#15
Suellen M T Cavalcanti, Cláudia Nunes, Sofia A C Lima, José L Soares-Sobrinho, Salette Reis
PURPOSE: An optimized methodology for the development of a new generation of lipid nanoparticles, the multiple lipid nanoparticles (MLN) is described. MLN have characteristics between nanostructured lipid carriers (NLC) and multiple emulsions (W/O/W), but without the outer aqueous phase. METHODS: The production is based on a hot homogenization method combined with high shear and ultrasonication. The antiretroviral agent lamivudine (3TC), was loaded in the MLN. For comparison purposes, NLC-3TC formulation was also developed and physico-chemically characterized by the same parameters as MLN-3TC...
March 17, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28314367/nanostructurization-of-fe-ni-alloy
#16
Vitaliy E Danilhenko
Data about an effect of cyclic γ-α-γ martensitic transformations on the structure state of reverted austenite Fe-31.7 wt.% Ni-0.06 wt.% C alloy are presented. The effect of multiple direct γ-α and reverse α-γ martensitic transformations on fragmentation of austenitic grains has been investigated by electron microscopy and X-ray diffraction methods. An ultrafine structure has been formed by nanofragmentation inside the initial austenite grains due to the successive misorientation of their crystal lattice...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28314143/a-hybrid-molecular-dynamics-study-on-the-non-newtonian-rheological-behaviors-of-shear-thickening-fluid
#17
Kaihui Chen, Yu Wang, Shouhu Xuan, Xinglong Gong
To investigate the microstructural evolution dependency on the apparent viscosity in shear-thickening fluids (STFs), a hybrid mesoscale model combined with stochastic rotation dynamics (SRD) and molecular dynamics (MD) is used. Muller-Plathe reverse perturbation method is adopted to analyze the viscosities of STFs in a two-dimensional model. The characteristic of microstructural evolution of the colloidal suspensions under different shear rate is studied. The effect of diameter of colloidal particles and the phase volume fraction on the shear thickening behavior is investigated...
March 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28306753/non-monotonic-dependence-of-pickering-emulsion-gel-rheology-on-particle-volume-fraction
#18
M Kaganyuk, A Mohraz
The microstructure of Pickering emulsion gels features a tenuous network of faceted droplets, bridged together by shared monolayers of particles. In this investigation, we use standard oscillatory rheometry in conjunction with confocal microscopy to gain a more comprehensive understanding of the role particle bridged interfaces have on the rheology of Pickering emulsion gels. The zero-shear elastic modulus of Pickering emulsion gels shows a non-monotonic dependence on particle loading, with three separate regimes of power-law and linear gel strengthening, and subsequent gel weakening...
March 17, 2017: Soft Matter
https://www.readbyqxmd.com/read/28306517/biomechanical-analysis-of-stiffness-and-fracture-displacement-after-using-pmma-augmented-sacroiliac-screw-fixation-for-sacrum-fractures
#19
Andreas Höch, Richard Schimpf, Niels Hammer, Stefan Schleifenbaum, Michael Werner, Christoph Josten, Jörg Böhme
Cement augmentation of pedicle screws is the gold standard for the stabilization of osteoporotic fractures of the spine. In-screw cement augmentation, in which cement is injected through the cannula, is another option for fracture stabilization of fragility fractures of the sacrum. However, biomechanical superiority of this technique compared to conventional sacroiliac screw fixation has not been tested. The present study compares the stability of cement-augmented and non-cement-augmented sacroiliac screw fixation in osteoporotic sacrum fractures under cyclic loading...
March 15, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28306291/new-paradigm-for-turbulent-transport-across-a-steep-gradient-in-toroidal-plasmas
#20
H S Xie, Y Xiao, Z Lin
First principles gyrokinetic simulation of the edge turbulent transport in toroidal plasmas finds a reverse trend in the turbulent transport coefficients under strong gradients. It is found that there exist both linear and nonlinear critical gradients for the nonmonotonicity of transport characteristics. The discontinuity of the transport flux slope around the turning gradient shows features of a second order phase transition. Under a strong gradient the most unstable modes are in nonground eigenstates with unconventional mode structures, which significantly reduces the effective correlation length and thus reverse the transport trend...
March 3, 2017: Physical Review Letters
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