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https://www.readbyqxmd.com/read/28227465/reaction-mechanism-of-blood-coagulation-factors-in-shear-flow-field
#1
Koki Kawakami, Daisuke Sakota, Ryo Kosaka, Masahiro Nishida, Yasuo Kawaguchi, Osamu Maruyama, Koki Kawakami, Daisuke Sakota, Ryo Kosaka, Masahiro Nishida, Yasuo Kawaguchi, Osamu Maruyama, Masahiro Nishida, Koki Kawakami, Ryo Kosaka, Yasuo Kawaguchi, Osamu Maruyama, Daisuke Sakota
Thrombus formation in blood pumps is a major problem. It has been reported that the shear rate is closely related to thrombus formation in blood pumps; however, the mechanism of blood coagulation in a shear flow field is not yet fully understood. The purpose of this study is to evaluate the effect of shear loading on the reaction of blood coagulation factors quantitatively. Human blood and porcine blood were used as test blood and sheared at 2,880 s(-1) for 3 h using a rheometer. After shear loading to the test blood, the activated partial thromboplastin time (APTT) and prothrombin time (PT) of sample plasma were measured using an automated coagulation analyzer...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227253/does-the-degree-of-coarctation-of-the-aorta-influence-wall-shear-stress-focal-heterogeneity
#2
John Gounley, Rafeed Chaudhury, Madhurima Vardhan, Michael Driscoll, Girish Pathangey, Kevin Winarta, Justin Ryan, David Frakes, Amanda Randles, John Gounley, Rafeed Chaudhury, Madhurima Vardhan, Michael Driscoll, Girish Pathangey, Kevin Winarta, Justin Ryan, David Frakes, Amanda Randles, Justin Ryan, Rafeed Chaudhury, Girish Pathangey, Amanda Randles, David Frakes, Kevin Winarta, Michael Driscoll, John Gounley, Madhurima Vardhan
The development of atherosclerosis in the aorta is associated with low and oscillatory wall shear stress for normal patients. Moreover, localized differences in wall shear stress heterogeneity have been correlated with the presence of complex plaques in the descending aorta. While it is known that coarctation of the aorta can influence indices of wall shear stress, it is unclear how the degree of narrowing influences resulting patterns. We hypothesized that the degree of coarctation would have a strong influence on focal heterogeneity of wall shear stress...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227224/cfd-analysis-of-strut-influence-on-blood-flow-in-stent-implanted-left-main-coronary-artery-bifurcation
#3
Yuya Yamada, Takahiro Tsukahara, Masahiro Motosuke, Yusuke Fujino, Yuya Yamada, Takahiro Tsukahara, Masahiro Motosuke, Yusuke Fujino, Takahiro Tsukahara, Yuya Yamada, Yusuke Fujino, Masahiro Motosuke
We numerically studied blood flows in a simulated branching pipe of coronary artery bifurcation, which is affected by stent implantation. We found that stent struts provide effects as guide vanes and blockages on the flow into circumflex branch. The former effect increases the flow rate and shear stress on the arteriosclerosis-prone site. The blockage effect may overwhelm the guide effect depending on a strut position against the inflow.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227120/tissue-characterization-using-simultaneous-estimation-of-backscatter-coefficient-and-elastic-shear-modulus
#4
Julien Rouyer, Gabriela Torres, Matthew W Urban, Roberto Lavarello, Julien Rouyer, Gabriela Torres, Matthew W Urban, Roberto Lavarello, Gabriela Torres, Matthew W Urban, Julien Rouyer, Roberto Lavarello
Tissue characterization using quantitative ultrasound (QUS) parameters has received significant attention in recent years due to its potential to improve the detection and diagnosis of diseased states. However, the vast majority of studies in QUS tissue typing have used parameters derived from either longitudinal or shear waves in isolation, thereby discarding potentially useful complementary information these parameters may carry. In this study, the simultaneous estimation of backscatter coefficients (derived from longitudinal waves) and shear modulus (derived from shear waves) was implemented on data from a clinical scanner...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227119/clinical-viability-of-carotid-plaque-strain-estimation-using-b-mode-ultrasound-image-sequences
#5
Amir A Khan, Joseph C Hecker, Brajesh K Lal, Siddhartha Sikdar, Amir A Khan, Joseph C Hecker, Brajesh K Lal, Siddhartha Sikdar, Siddhartha Sikdar, Brajesh K Lal, Amir A Khan, Joseph C Hecker
It is estimated that approximately 30% of ischemic strokes are caused by rupture of plaque in the carotid artery. Development of techniques focusing on identifying plaques that are vulnerable to rupture is thus indispensable for stroke prevention. Recent studies have demonstrated that motion analysis of plaques from B-mode and RF ultrasound (US) image sequences can be used to estimate plaque strain. However, viability of these methods in a clinical setting, with variable acquisition protocols, has not been demonstrated yet...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227118/shear-wave-elastography-using-wigner-ville-distribution-a-simulated-multilayer-media-study
#6
Pooya Sobhe Bidari, Javad Alirezaie, Jahan Tavakkoli, Pooya Sobhe Bidari, Javad Alirezaie, Jahan Tavakkoli, Javad Alirezaie, Jahan Tavakkoli
Shear Wave Elastography (SWE) is a quantitative ultrasound-based imaging modality for distinguishing normal and abnormal tissue types by estimating the local viscoelastic properties of the tissue. These properties have been estimated in many studies by propagating ultrasound shear wave within the tissue and estimating parameters such as speed of wave. Vast majority of the proposed techniques are based on the cross-correlation of consecutive ultrasound images. In this study, we propose a new method of wave detection based on time-frequency (TF) analysis of the ultrasound signal...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227117/altered-viscoelastic-properties-of-stroke-affected-muscles-estimated-using-ultrasound-shear-waves-preliminary-data
#7
Ghulam Rasool, Allison B Wang, William Z Rymer, Sabrina S M Lee, Ghulam Rasool, Allison B Wang, William Z Rymer, Sabrina S M Lee, Ghulam Rasool, Sabrina S M Lee, Allison B Wang, William Z Rymer
As a result of a brain injury such as stroke, the skeletal muscles may undergo numerous structural and functional alterations. These abnormal changes are linked to muscle weakness, joint contracture, and abnormal muscle tone and eventually, result in motor impairment. A subset of these alterations affects passive muscle stiffness, i.e., viscoelastic properties. However, in vivo estimation of changes in viscoelastic properties is a challenging task. Here, we used the shear wave velocity, estimated through ultrasound SuperSonic imaging (SSI), as a surrogate for viscoelastic properties...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227067/computational-estimation-of-the-severity-of-coronary-lesions-with-intravascular-ultrasound-images-a-pilot-study
#8
Panagiotis K Siogkas, Michail I Papafaklis, Bill D Gogas, Habib Samady, Lampros K Michalis, Dimitrios I Fotiadis, Panagiotis K Siogkas, Michail I Papafaklis, Bill D Gogas, Habib Samady, Lampros K Michalis, Dimitrios I Fotiadis, Bill D Gogas, Habib Samady, Michail I Papafaklis, Dimitrios I Fotiadis, Panagiotis K Siogkas, Lampros K Michalis
The fast and accurate hemodynamic functional assessment of the coronary vasculature is of utmost importance in clinical practice due to the fact that Cardiovascular Diseases have become the leading cause of death globally. In this work we propose a novel method that combines two of the most efficient methods of hemodynamic status assessment of coronary arteries, Intravascular UtraSound and virtual Functional Assessment Index, an index that correlates well to the measured Fractional Flow Reserve. One Left Anterior Descending segment was reconstructed both in a straight manner (using only IVUS images) as well as using the actual 3D geometry of the vessel (using IvUS images combined with the respective coronary angiographic images [2])...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226977/establishment-of-a-measurement-method-for-in-shoe-pressure-and-shear-stress-in-specific-regions-for-diabetic-ulcer-prevention
#9
Ayumi Amemiya, Hiroshi Noguchi, Makoto Oe, Hiromi Sanada, Taketoshi Mori, Ayumi Amemiya, Hiroshi Noguchi, Makoto Oe, Hiromi Sanada, Taketoshi Mori, Makoto Oe, Ayumi Amemiya, Hiromi Sanada, Hiroshi Noguchi, Taketoshi Mori
Pressure and shear stress are the factors of diabetic foot ulcers and callus formation. However, in-shoe shear stress of callus measurement could not have been measured because of technical difficulties. The purpose of this study is to verify reliability and validity of the established measurement system for in-shoe pressure and shear stress. For reliability, coefficients of variation (CV) and intraclass correlation coefficients (ICC) were confirmed. For known-groups validity, callus and non-callus feet were compared...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226917/development-of-a-planar-shear-sensor
#10
Bruce J P Mortimer, Gary A Zets, Brian J Altenbernd, Tharaka Goonetilleke, Bruce J P Mortimer, Gary A Zets, Brian J Altenbernd, Tharaka Goonetilleke, Bruce J P Mortimer, Tharaka Goonetilleke, Gary A Zets, Brian J Altenbernd
This paper describes a wearable sensor that simultaneously measures both shear and orthogonal force. The planar shear sensor is based on inductive coupling between a small target and a series of adjacent coils. Lateral movement of the target changes the coupling between a primary coil and a series of geometrically shaped and scaled sense coils. Design of the sensor and methods for calibration are investigated. The wearable sensor can be used for measurement of in-situ foot loading during ambulation and we postulate that this may be useful for biomechanical analysis including exoskeletons and balance rehabilitation applications...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226916/a-pressure-and-shear-sensing-liner-for-prosthetic-sockets
#11
Jason Wheeler, Anirban Mazumdar, Lisa Marron, Kevin Dullea, Joan Sanders, Kate Allyn, Jason Wheeler, Anirban Mazumdar, Lisa Marron, Kevin Dullea, Joan Sanders, Kate Allyn, Kevin Dullea, Joan Sanders, Kate Allyn, Anirban Mazumdar, Lisa Marron, Jason Wheeler
Interface pressures are closely related to the comfort and fit of a lower-limb prosthetic socket and clinicians and researchers are interested in monitoring these loads. In particular, shear stresses at the socket/liner interface are indicative of important fit characteristics but are difficult to measure in situ. We have developed an elastomeric liner with sixteen integrated pressure and shear sensors, along with necessary wiring and data acquisition electronics. The sensors measure three-axis pressures using optical emitter/detector pairs coupled with transparent and opaque elastomeric layers...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226720/comparison-of-viscoelastic-property-characterization-of-plastisol-phantoms-with-magnetic-resonance-elastography-and-high-frequency-rheometry
#12
P M Lefebvre, K Tse Ve Koon, E Brusseau, S Nicolle, J-F Palieme, S A Lambert, D Grenier, P M Lefebvre, K Tse Ve Koon, E Brusseau, S Nicolle, J-F Palieme, S A Lambert, D Grenier, P M Lefebvre, E Brusseau, S Nicolle, D Grenier, S A Lambert
This study aims at evaluating Magnetic Resonance Elastography (MRE) as a reliable technique for the characterization of viscoelastic properties of soft tissues. Three phantoms with different concentrations of plastisol and softener were prepared in order to mechanically mimic a broad panel of healthy and pathological soft tissues. Once placed in a MRI device, each sample was excited by a homemade external driver, inducing shear waves within the medium. The storage (G') and loss (G") moduli of each phantom were then reconstructed from MRE acquisitions over a frequency range from 300 to 1,000 Hz, by applying a 2D Helmholtz inversion algorithm...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226495/a-pmma-microfluidic-dielectric-sensor-for-blood-coagulation-monitoring-at-the-point-of-care
#13
Debnath Maji, Michael A Suster, Erdem Kucukal, Umut A Gurkan, Evi X Stavrou, Pedram Mohseni, Debnath Maji, Michael A Suster, Erdem Kucukal, Umut A Gurkan, Evi X Stavrou, Pedram Mohseni, Umut A Gurkan, Pedram Mohseni, Debnath Maji, Erdem Kucukal, Evi X Stavrou, Michael A Suster
This paper describes the design and construct of a fully biocompatible, microfluidic, dielectric sensor targeted at monitoring human whole blood coagulation at the point-of-care (POC). The sensor assembly procedure involves using sputtered electrodes in a microfluidic channel with a physiologically relevant height of 50μm to create a three-dimensional (3D), parallel-plate, capacitive sensing area. The sensor is constructed with biocompatible materials of polymethyl methacrylate (PMMA) for the substrate and titanium nitride (TiN) for the sensing and floating electrodes...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225604/a-microfluidic-device-for-studying-controllable-hydrodynamic-flow-induced-cellular-responses
#14
Chunhong Zheng, Xiannian Zhang, Chunmei Li, Yuhong Pang, Yanyi Huang
Hydrodynamic flow is an essential stimulus in many cellular functions, regulating many mechanical sensitive pathways and closely associating with human health status and diseases. The flow pattern of blood in vessels is the key factor in causing atherosclerosis. Hemodynamics has great effect on endothelial cells' gene expression and biological functions. There are various tools that can be used for studying flow-induced cellular responses but most of them are either bulky or lack of precise controllability...
February 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28225384/star-syndrome-a-further-case-and-the-first-report-of-maternal-mosaicism
#15
Henrietta Lefroy, Jane A Hurst, Deborah J Shears
No abstract text is available yet for this article.
February 20, 2017: Clinical Dysmorphology
https://www.readbyqxmd.com/read/28225181/two-phase-reactions-in-microdroplets-without-the-use-of-phase-transfer-catalysts
#16
Xin Yan, Heyong Cheng, Richard N Zare
Many important chemical transformations occur in two-phase reactions, which are widely used in chemical, pharmaceutical, and polymer manufacturing. We present an efficient method for performing two-phase reactions in microdroplets sheared by sheath gas without using a phase-transfer catalyst. This avoids disadvantages such as thermal instability, high cost, and, especially, the need to separate and recycle the catalysts. We show that various alcohols can be oxidized to the corresponding aldehydes and ketones within milliseconds in moderate to good yields (50-75 %)...
February 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28225013/corrigendum-succeed-escape-flow-shear-promotes-tumbling-of-escherichia-coli-near-a-solid-surface
#17
Mehdi Molaei, Jian Sheng
No abstract text is available yet for this article.
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28224248/vis-nir-spectroscopy-with-moving-window-pls-method-applied-to-rapid-analysis-of-whole-blood-viscosity
#18
Jiemei Chen, Zhiwei Yin, Yi Tang, Tao Pan
A rapid analytical method of human whole blood viscosity with low, medium, and high shear rates [WBV(L), WBV(M), and WBV(H), respectively] was developed using visible and near-infrared (Vis-NIR) spectroscopy combined with a moving-window partial least squares (MW-PLS) method. Two groups of peripheral blood samples were collected for modeling and validation. Separate analytical models were established for male and female groups to avoid interference in different gender groups and improve the homogeneity and prediction accuracy...
February 21, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28224160/particle-wall-tribology-of-slippery-hydrogel-particle-suspensions
#19
Heather M Shewan, Jason R Stokes, Michel Cloitre
Slip is an important phenomenon that occurs during the flow of yield stress fluids like soft materials and pastes. Densely packed suspensions of hydrogel microparticles are used to show that slip is governed by the tribological interactions occurring between the samples and shearing surfaces. Both attractive/repulsive interactions between the dispersed particles and surface, as well as the viscoelasticity of the suspension, are found to play key roles in slip occurring within rheometric flows. We specifically discover that for two completely different sets of microgels, the sliding stress at which slip occurs scales with both the modulus of the particles and the bulk suspension modulus...
February 22, 2017: Soft Matter
https://www.readbyqxmd.com/read/28224070/combined-particulated-juvenile-cartilage-allograft-transplantation-and-medial-patellofemoral-ligament-reconstruction-for-symptomatic-chondral-defects-in-the-setting-of-recurrent-patellar-instability
#20
Armin Arshi, Dean Wang, Kristofer J Jones
Successful management of patellar osteochondral lesions has proved difficult, with unreliable outcomes reported using traditional cartilage repair and restoration procedures. Unique considerations for this type of defect include the multiplanar contours of the articular surface of the patella, high compressive and shear forces with knee range of motion that may disrupt graft healing, and the potential need for concomitant surgery to address patellar malalignment and instability. We describe our preferred method for treatment of a symptomatic chondral defect in the setting of recurrent patellar instability using particulated juvenile articular cartilage allograft transplantation and medial patellofemoral ligament reconstruction with semitendinosus allograft...
October 2016: Arthroscopy Techniques
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