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https://www.readbyqxmd.com/read/28938393/ilizarov-treatment-protocols-in-the-management-of-infected-nonunion-of-the-tibia
#1
Martin McNally, Jamie Ferguson, Raj Kugan, David Stubbs
OBJECTIVES: We present a treatment algorithm comprising 4 Ilizarov methods in managing infected tibial nonunion, using nonunion mobility and segmental defect size to govern treatment choice. DESIGN: Decision protocol analysis study. SETTING: A university-affiliated teaching hospital. PATIENTS/PARTICIPANTS: Seventy-nine patients were treated with 1 of 4 Ilizarov protocols. All patients had undergone at least one previous operation, 38 had associated limb deformity, and 49 had nonviable nonunions...
October 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28938271/the-t-now-matters-the-eighth-edition-of-the-union-for-international-cancer-control-classification-of-pancreatic-adenocarcinoma
#2
Thilo Welsch, Adrian Seifert, Benjamin Müssle, Marius Distler, Daniela E Aust, Jürgen Weitz
BACKGROUND: The new 8th edition of the Union for International Cancer Control (UICC) classification of TNM staging includes relevant changes for pancreatic cancer (PC). We report on the survival stratification of the new T and N stages. METHODS: The 8th edition TNM system was retrospectively applied to patients who underwent curative PC resection at our institution between 2005-2015. RESULTS: Some 256 patients were included. The postoperative TNM stage was pT3 in 96% of the cases according to the 7th edition of UICC staging...
September 21, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28938234/is-early-total-care-a-safe-and-effective-alternative-to-staged-protocol-for-the-treatment-of-schatzker-iv-vi-tibial-plateau-fractures-in-patients-older-than-50-years
#3
Amrut Borade, Harish Kempegowda, Raveesh Richard, Jove Graham, Michael Suk, Daniel S Horwitz
OBJECTIVES: To compare "Early Total Care" (ETC) with "Staged Protocol" (SP) for the treatment of Schatzker IV-VI tibial plateau fractures in patients older than 50 years regarding safety and effectiveness. DESIGN: Retrospective cohort study. SETTING: An academic level 1 US trauma center. PATIENTS/PARTICIPANTS: Eighty-one patients older than 50 years with Schatzker grade IV-VI tibial plateau fractures were included. INTERVENTION: Fifty-three patients were treated under SP with immediate external fixation followed by definitive internal fixation...
September 19, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28937598/the-effect-of-rankl-opg-balance-on-reducing-implant-complications
#4
REVIEW
Elizabeth R Kapasa, Peter V Giannoudis, Xiaodong Jia, Paul V Hatton, Xuebin B Yang
Despite the phenomenal success of implants particularly in the realms of dentistry and orthopaedics, there are still challenges to overcome. The failure of implants resulting from infection, prosthetic loosening, and non-union continue to be the most notorious examples. The cascade of fracture healing and bone repair, especially with the presence of an implant, is complex because it involves a multifaceted immune response alongside the intricate process of bone formation and remodelling. Bone loss is a serious clinical problem that is frequently accompanied by chronic inflammation, illustrating that there is a convoluted relationship between inflammation and bone erosion...
September 22, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28937005/quota-in-specialty-and-super-specialty-courses-what-does-the-judiciary-say
#5
Mukul Chandra Kapoor, Shubhendu Anand
Reservations in super-specialty courses have been controversial for decades. A number of practising doctors, medical students and others in society have wanted to do away with reservations in specialty and super-specialty courses, while there are others in favour of persisting with reservations. Article 15 (4) of the Constitution of India states that nothing shall prevent the State from making any special provision for the advancement of any socially and educationally backward classes of citizens or for the Scheduled Castes/Tribes...
May 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/28936356/implementation-of-the-european-health-interview-survey-ehis-into-the-german-health-update-geda
#6
C Lange, J D Finger, J Allen, S Born, J Hoebel, R Kuhnert, S Müters, J Thelen, P Schmich, M Varga, E von der Lippe, M Wetzstein, T Ziese
BACKGROUND: This methodological paper describes the integration of the 'European Health Interview Survey wave 2' (EHIS 2) into the 'German Health Update' 2014/2015 (GEDA 2014/2015-EHIS). METHODS: GEDA 2014/2015-EHIS is a cross-sectional health survey. A two-stage stratified cluster sampling approach was used to recruit persons aged 15 years and older with permanent residence in Germany. Two different modes of data collection were used, self-administered web questionnaire and self-administered paper questionnaire...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28936133/migrants-decision-process-shaping-work-destination-choice-the-case-of-long-term-care-work-in-the-united-kingdom-and-norway
#7
Karen Christensen, Shereen Hussein, Mohamed Ismail
Escalating demands for formal long-term care (LTC) result in the reliance on migrant workers in many developed countries. Within Europe, this is currently framed by progressive European immigration policies favouring inter-European mobility. Using the UK and Norway as case studies, this article has two main aims: (1) to document changes in the contribution of European Union (EU) migrants to the LTC sectors in Western Europe, and (2) to gain further understanding of migrants' decision-processes relating to destination and work choices...
September 2017: European Journal of Ageing
https://www.readbyqxmd.com/read/28935772/the-european-medicines-agency-review-of-carfilzomib-for-the-treatment-of-adult-patients-with-multiple-myeloma-who-have-received-at-least-one-prior-therapy
#8
Kyriaki Tzogani, Jorge Camarero Jiménez, Isabel Garcia, Arantxa Sancho-López, Marc Martin, Alexandre Moreau, Pierre Demolis, Tomas Salmonson, Jonas Bergh, Edward Laane, Heinz Ludwig, Christian Gisselbrecht, Francesco Pignatti
On November 19, 2015, a marketing authorization valid through the European Union was issued for carfilzomib in combination with lenalidomide and dexamethasone for the treatment of adult patients with multiple myeloma (MM) who have received at least one prior therapy.In a phase III trial in patients with relapsed MM, median progression-free survival (PFS) for patients treated with carfilzomib in combination with lenalidomide and dexamethasone (CRd) was 26.3 months versus 17.6 months for those receiving lenalidomide and dexamethasone alone (hazard ratio = 0...
September 21, 2017: Oncologist
https://www.readbyqxmd.com/read/28935732/complete-genome-sequences-of-emm111-type-streptococcus-pyogenes-strain-gur-with-antitumor-activity-and-its-derivative-strain-gursa1-with-an-inactivated-emm-gene
#9
Maria A Suvorova, Anna N Tsapieva, Emilie Glad Bak, Valery A Chereshnev, Ekaterina P Kiseleva, Alexander N Suvorov, Manimozhiyan Arumugam
We present here the complete genome sequence of Streptococcus pyogenes type emm111 strain GUR, a throat isolate from a scarlet fever patient, which has been used to treat cancer patients in the former Soviet Union. We also present the complete genome sequence of its derivative strain GURSA1 with an inactivated emm gene.
September 21, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28935593/factors-affecting-peri-implant-fracture-following-locking-plate-for-osteoporotic-distal-femur-fractures
#10
Ki-Chul Park, Seung-Jae Lim, Young Sik Song, Kyu-Tae Hwang
INTRODUCTION: The purpose of this study is to evaluate the outcomes and to analyze the risk factors for the occurrence of peri-implant fracture after treatment of osteoporotic distal femoral fracturesusing a locking plate. HYPOTHESIS: Risk factors affecting peri-implant fracture exist after locking plate fixation in osteoporotic distal femur fracture. MATERIALS AND METHODS: Eighty nine(88 patients) with osteoporotic distal femoral fractures were evaluated between January2006 and January2014...
September 18, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28935231/pandemic-legislation-in-the-european-union-fit-for-purpose-the-need-for-a-systematic-comparison-of-national-laws
#11
Elizabeth M Speakman, Scott Burris, Richard Coker
Sound governance is central to effective pandemic management. Key international legal instruments governing pandemic management in the European Union (EU): the International Health Regulations (2005) and Decision 1082/13 require EU Member States to develop national plans and invite them to establish national legal frameworks to support compliance with this international legislation. Although Member States may design the legal framework as they choose, the strongest instrument of pandemic governance is national legislation...
September 1, 2017: Health Policy
https://www.readbyqxmd.com/read/28935015/-egfr-and-kras-gene-mutations-in-754-patients-with-resectable-stage-i-iiia-non-small-cell-lung-cancer-and-its-clinical-significance
#12
Jing Zhao, Jie Gao, Liping Guo, Xiaoxu Hu, Qi Liu, Jinyin Zhao, Licheng Liu, Jun Jiang, Mengzhao Wang, Zhiyong Liang, Yan Xu, Minjiang Chen, Li Zhang, Longyun Li, Wei Zhong
BACKGROUND: Epidermal growth factor receptor (EGFR) and KRAS gene are important driver genes of non-small cell lung cancer (NSCLC). The studies are mainly focused on detection of EGFR gene for advanced NSCLC, and the mutation feature of EGFR and KRAS gene in early NSCLC tissue is unknown. This study aims to investigate the mutations of EGFR and KRAS gene in NSCLC, and the relationship between the genotype and clinicopathologic features. METHODS: The hotspot mutations in EGFR and KRAS gene in 754 tissue samples of stage I-IIIa NSCLC from Department of Pathology, Peking Union Medical College Hospital were detected by modified amplification refractory mutation system (ARMS) real-time PCR kit, and analyzed their correlation with clinical variables...
September 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28934852/stereoselective-tandem-bis-electrophile-couplings-of-diborylmethane
#13
Stephanie A Murray, Michael Z Liang, Simon J Meek
A copper-catalyzed three-component linchpin coupling method for the stereoselective union of readily available epoxides and allyl electrophiles is disclosed. Transformations employ [B(pin)]2-methane as a conjunctive reagent, resulting in the formation of two C-C bonds at a single carbon center bearing a C(sp3) organoboron functional group. Products are obtained in 42-99% yield, and up to >20:1 dr. The utility of the approach is highlighted by stereospecific transformations entailing allylation, tandem cross coupling, and application to the synthesis 1,3-polyol motifs...
September 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28934639/changes-in-nursing-students-expectations-of-nursing-clinical-faculties-competences-a-longitudinal-mixed-methods-study
#14
Robert Lovrić, Nada Prlić, Dragana Milutinović, Igor Marjanac, Boštjan Žvanut
BACKGROUND: Changes in nursing students' expectations of their clinical nursing faculty competences over the course of time are an insufficiently researched phenomenon. OBJECTIVES: To explore what competences BSc nursing students expect from their clinical faculties during their clinical training, and whether their expectations changed during their three-year studies. Furthermore, to survey factors which influenced their expectations and whether the fulfilment levels of their expectations influenced their feelings, learning, and behaviour...
September 8, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28934070/presence-of-trihalomethanes-in-ready-to-eat-vegetables-disinfected-with-chlorine
#15
Valentina Coroneo, Valentina Carraro, Barbara Marras, Alessandro Marrucci, Sara Succa, Barbara Meloni, Antonella Pinna, Alberto Angioni, Adriana Sanna, Marco Schintu
Trihalomethanes (THMs) - CHCl3, CHCl2Br, CHClBr2 and CHBr3 - are drinking water disinfection by-products (DBPs). These compounds can also be absorbed by different types of foods, including ready-to-eat (RTE) fresh vegetables. The potential absorption of THMs during washing of RTE vegetables could pose a potential risk to consumers' health. The concentration of THMs in the water used in the manufacturing process of these products shall not exceed the limit of 100 or 80 µgL(-1) according to European Union (EU) and United States legislation respectively...
September 21, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28933928/nursing-and-the-public-health-legacies-of-the-russian-revolution
#16
Susan Grant
The centenary of the October Revolution in 1917 provides a timely opportunity to assess the legacies of that event. I examine the role of the revolution in public health with a focus on nursing, assessing the Imperial Russian health care system, the development of Soviet nursing, and current plans for nursing and public health care in Putin's Russia. Analyzing nursing shows that there was a great deal of continuity in terms of medical personnel and ideas on how public health care service in Russia should operate...
September 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28933922/alan-gregg-the-diary-of-a-thoughtful-eye-witness
#17
Susan Ladwig, Theodore Brown
After two years of discussions and delays surrounding his eventual departure, Alan Gregg, the 37-year-old associate director of the Rockefeller Foundation's Division of Medical Education (DME), set out from his Paris, France, office in late November 1927, destined for a 17-day trip to Moscow and Leningrad in the Soviet Union. His mission-the first time a Rockefeller officer had ever set foot on Soviet soil(1)-was to gather first-hand knowledge about the state of public health and medical education in Russia, as a precursor for offering training fellowships to Russian physicians...
September 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28933833/total-synthesis-of-nahuoic-acid-ci-bii
#18
Qi Liu, Yifan Deng, Amos B Smith
A convergent total synthesis of (-)-nahuoic acid Ci(Bii) (3), a novel cis-decalin polyketide, has been achieved. Key synthetic transformations include Type II Anion Relay Chemistry (ARC) to construct the polyol chain, a Ti-catalyzed asymmetric Diels-Alder reaction to generate the cis-decalin skeleton, and a late-stage large fragment union exploiting a Micalizio alkoxide-directed alkyne-alkene coupling tactic.
September 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28933768/chronic-respiratory-diseases-in-the-regions-of-northern-russia-epidemiological-distinctions-in-the-results-of-a-national-population-study
#19
Marine H Gambaryan, Svetlana A Shalnova, Alexander D Deev, Oxana M Drapkina
The aim of the study is to investigate the epidemiological situation regarding chronic respiratory diseases in populations that inhabit different climatic-geographical regions of Russia, and to develop targeted programs for prevention of these diseases. METHODS: (1) a comparative analysis of the standardized mortality data in Russia and other selected regions of the Russian North using the European standard for respiratory diseases, in a population aged 25-64; and (2) data from a randomized cross-sectional epidemiological study, with subjects from three different climatic-geographical regions of Russia...
July 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28933625/immunogenicity-and-safety-of-a-split-virion-quadrivalent-influenza-vaccine-in-adults-18-60%C3%A2-years-of-age-in-the-republic-of-korea
#20
Won Suk Choi, Ji Yun Noh, Jacob Lee, Jun Yong Choi, Jin-Soo Lee, Moo Soo Kim, Hee Soo Kim, Joon Bang, Nathalie Lavis, Woo Joo Kim
VaxigripTetra® (Sanofi Pasteur, Lyon, France) is a quadrivalent split-virion inactivated influenza vaccine (IIV4) containing two B-lineage strains approved in the European Union and Taiwan in 2016 for individuals ≥ 3 years of age. Here, we describe an observer-blind, randomized, controlled, multicenter trial study evaluating the immunogenicity and safety of the Northern Hemisphere 2015-2016 formulations of IIV4 and the licensed split-virion trivalent inactivated influenza vaccine (IIV3) in the Republic of Korea (ClinicalTrials...
September 21, 2017: Human Vaccines & Immunotherapeutics
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