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https://www.readbyqxmd.com/read/29164565/a-naturally-inspired-curcumin-based-lecithin-formulation-meriva%C3%A2-formulated-as-the-finished-product-algocur%C3%A2-alleviates-the-osteo-muscular-pain-conditions-in-rugby-players
#1
F Di Pierro, P Zacconi, A Bertuccioli, S Togni, R Eggenhoffner, L Giacomelli, S Scaltrini
OBJECTIVE: Curcumin is one of the most investigated phytochemical products because of its low toxicity and its broad spectrum of bioactivity, including anti-inflammatory and analgesic properties. A new delivery form of curcumin, resorting to phosphatidylcholine (Meriva®, formulated as the finished product Algocur®) has been developed to increase its bioavailability. In this study, we tested the efficacy and safety of a Meriva®-based product in rugby players suffering by different osteo-muscular pain conditions PATIENTS AND METHODS: In this pilot study, 50 male rugby players with osteo-muscular pain due to traumatic injuries, physical overload or acute episode of chronic pain were recruited and treated with conventional analgesic drugs (n = 25) or Meriva®-based product (n = 25) for a maximum of 10 days...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164118/infections-caused-by-antimicrobial-drug-resistant-saprophytic-gram-negative-bacteria-in-the-environment
#2
Eva Raphael, Lee W Riley
Background: Drug-resistance genes found in human bacterial pathogens are increasingly recognized in saprophytic Gram-negative bacteria (GNB) from environmental sources. The clinical implication of such environmental GNBs is unknown. Objectives: We conducted a systematic review to determine how often such saprophytic GNBs cause human infections. Methods: We queried PubMed for articles published in English, Spanish, and French between January 2006 and July 2014 for 20 common environmental saprophytic GNB species, using search terms "infections," "human infections," "hospital infection...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29156519/in-vivo-assessment-of-the-osteo-protective-effects-of-eugenol-in-alveolar-bone-tissues
#3
Hatem M Abuohashish, Dina A Khairy, Maha M Abdelsalam, Ahmed Alsayyah, Mohammed M Ahmed, Salim S Al-Rejaie
Estrogen deficiency following menopausal provokes alveolar bone loss, remodeling and inflammation. Eugenol is a phenolic compound with wide dental applications and anti-inflammatory properties. In the present study, the potential protective role of eugenol against alveolar bone deformities was investigated in an ovariectomized (OVX) rodent model. Two doses of eugenol (2.5 and 5 mg/kg/d) were administered to OVX animals for 12 weeks. In Serum, markers of bone metabolism and pro-inflammatory cytokines were estimated using ELISA...
November 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29155819/determinants-of-site-of-tuberculosis-disease-an-analysis-of-european-surveillance-data-from-2003-to-2014
#4
Giovanni Sotgiu, Dennis Falzon, Vahur Hollo, Csaba Ködmön, Nicolas Lefebvre, Andrei Dadu, Marieke van der Werf
BACKGROUND: We explored host-related factors associated with the site of tuberculosis (TB) disease using variables routinely collected by the 31 EU/EEA countries for national surveillance. METHODS: Logistic regression models were fitted to case-based surveillance data reported to the European Centre for Disease Prevention and Control for TB cases notified from 2003 to 2014. Missing data on HIV infection and on susceptibility to isoniazid and rifampicin for many patients precluded the inclusion of these variables in the analysis...
2017: PloS One
https://www.readbyqxmd.com/read/29152248/nutritional-management-of-search-and-rescue-dogs
#5
G Vassalotti, N Musco, P Lombardi, S Calabrò, R Tudisco, V Mastellone, R Grazioli, S Bianchi, M I Cutrignelli
Dogs used for search and rescue (SAR) may experience continuous micro-traumas that predispose them to skeletal disorders. The aim of the present study was to evaluate the effect of diet on osteo-articular apparatus in healthy SAR dogs. A total of sixteen SAR dogs were divided into two groups (low supplementation (LS) and high supplementation (HS)) and were fed for 3 months with two experimental diets, characterised by the same protein and energy density, but different in n-3 PUFA (6·2 v. 8·4 % of metabolisable energy), chondroitin sulfate (219·8 v...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29143185/osteogenic-prospective-of-deriving-human-dental-stem-cells-in-collagen-matrix-boost
#6
Tong-Jing Fang, Ding-Han Wang, Chia-Yu Wang, Raju Poongodi, Nien-Hsien Liou, Jiang-Chuan Liu, Ming-Lun Hsu, Po-Da Hong, Shih-Fang Yang, Meng-Lun Liu
Stem cells derived from oral tissue represent a highly attractive alternative source for clinical bone regeneration because they can be collected by non-invasive or minimally invasive procedures. Herein, we describe the human dental stem cells (DSCs) deriving from buccal fat pads (BFP), dental pulp (DP) of impacted teeth, and periodontal ligaments (PDL) to obtain BFPSCs, DPSCs, and PDLSCs, respectively. Cells were purified with selected medium and expanded through passages in stem cell culture medium. Purified cells were characterized for stemness by their growth rate, immunostaining, and multilineage differentiation ability...
November 15, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29143002/nanotopography-based-strategy-for-the-precise-manipulation-of-osteoimmunomodulation-in-bone-regeneration
#7
REVIEW
Zetao Chen, Akash Bachhuka, Fei Wei, Xiaoshuang Wang, Guanqi Liu, Krasimir Vasilev, Yin Xiao
Immune cells play vital roles in regulating bone dynamics. Successful bone regeneration requires a favourable osteo-immune environment. The high plasticity and diversity of immune cells make it possible to manipulate the osteo-immune response of immune cells, thus modulating the osteoimmune environment and regulating bone regeneration. With the advancement in nanotechnology, nanotopographies with different controlled surface properties can be fabricated. On tuning the surface properties, the osteo-immune response can be precisely modulated...
November 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/29111380/hypoxia-inducible-factor-1%C3%AE-may-regulate-the-commitment-of-mesenchymal-stromal-cells-toward-angio-osteogenesis-by-mirna-675-5p
#8
Viviana Costa, Lavinia Raimondi, Alice Conigliaro, Francesca Salamanna, Valeria Carina, Angela De Luca, Daniele Bellavia, Riccardo Alessandro, Milena Fini, Gianluca Giavaresi
BACKGROUND AIMS: During bone formation, angiogenesis and osteogenesis are regulated by hypoxia, which is able to induce blood vessel formation, as well as recruit and differentiate human mesenchymal stromal cells (hMSCs). The molecular mechanisms involved in HIF-1α response and hMSC differentiation during bone formation are still unclear. This study aimed to investigate the synergistic role of hypoxia and hypoxia-mimetic microRNA miR-675-5p in angiogenesis response and osteo-chondroblast commitment of hMSCs...
October 27, 2017: Cytotherapy
https://www.readbyqxmd.com/read/29081861/role-of-surgery-in-management-of-osteo-articular-tuberculosis-of-the-foot-and-ankle
#9
REVIEW
Mandeep Singh Dhillon, Vikas Agashe, Sampat Dumbre Patil
BACKGROUND: Tuberculosis of the foot and ankle still remains to be a significant problem, especially in the developing countries, and with an increase in incidence in immunosuppressed patients. Treatment is mainly medical using multidrug chemotherapy; surgical interventions range from biopsy, synovectomy and debridement, to joint preserving procedures like distraction in early cases, and arthrodesis of hindfoot joints and the ankle in advanced disease with joint destruction. Surgical Options: All procedures should be done after initiating appropriate medical management...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29079596/erythropoietin-inhibits-osteoblast-function-in-myelodysplastic-syndromes-via-the-canonical-wnt-pathway
#10
Ekaterina Balaian, Manja Wobus, Heike Weidner, Ulrike Baschant, Maik Stiehler, Gerhard Ehninger, Martin Bornhäuser, Lorenz C Hofbauer, Martina Rauner, Uwe Platzbecker
The effects of erythropoietin on osteoblasts and bone formation are controversially discussed. Since patients with myelodysplastic syndromes often display excessively high erythropoietin level, we aimed to analyze the effect of erythropoietin on osteoblast function in myelodysplastic syndromes and define the role of Wnt signaling in this process. Expression of osteoblast-specific genes and subsequent osteoblasts mineralization was increased in mesenchymal stromal cells from healthy young donors by in vitro erythropoietin treatment...
October 27, 2017: Haematologica
https://www.readbyqxmd.com/read/29066312/dicer1-ablation-in-osterix-positive-bone-forming-cells-affects-cortical-bone-homeostasis
#11
Ameya Bendre, Niko Moritz, Vilma Väänänen, Jorma A Määttä
The RNAse III enzyme Dicer plays a major role in the processing of microRNAs from large pre-miRNAs. Dicer1 processed microRNAs are known to play a comprehensive role in osteoblast differentiation, bone remodeling and skeletal disorders. Targeted deletion of Dicer1 in osteo-progenitor cells is deleterious to fetal survival whereas targeted deletion in mature osteoblasts leads to an increase in bone mass. To address the role of Dicer1 in post-natal skeletal homeostasis, we generated a pre-osteoblast specific Dicer1 knockout model employing Tamoxifen controllable Cre allele, enabling us, via tamoxifen administration, to time-controllably ablate Dicer1 gene expression in osterix expressing bone forming cells in post-natal mice...
October 21, 2017: Bone
https://www.readbyqxmd.com/read/29061958/%C3%AE-linolenic-acid-inhibits-receptor-activator-of-nf-%C3%AE%C2%BAb-ligand-induced-rankl-induced-osteoclastogenesis-and-prevents-inflammatory-bone-loss-via-downregulation-of-nuclear-factor-kappab-inducible-nitric-oxide-synthases-nf-%C3%AE%C2%BAb-inos-signaling-pathways
#12
Jiefu Song, Zhizhen Jing, Wei Hu, Jianping Yu, Xiaoping Cui
BACKGROUND Inflammation is a major cellular strain causing increased risk of osteo-degenerative diseases. Omega-3 fatty acids have been great source in suppressing inflammation. We investigated the effect of α-linolenic acid (ALA) on RANKL-stimulated osteoclast differentiation, LPS-induced and ovariectomized bone loss in mice models. MATERIAL AND METHODS The bone marrow macrophages (BMMs) were isolated from femurs of ICR mice, stimulated with RANKL, and treated with ALA (100, 200, 300 µM). Major analytical methods include histological analysis, osteoclasts viability assay, serum cytokines and chemokines ELISA, and gene expression by qPCR...
October 24, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29049924/equine-mesenchymal-stem-cells-derived-from-endometrial-or-adipose-tissue-share-significant-biological-properties-but-have-distinctive-pattern-of-surface-markers-and-migration
#13
J Cabezas, D Rojas, F Navarrete, R Ortiz, G Rivera, F Saravia, L Rodriguez-Alvarez, F O Castro
Adult stromal mesenchymal stem cells (MSCs) have been postulated as responsible for cell renewal in highly and continuously regenerative tissues such as the endometrium. MSCs have been identified in the endometrium of many species including humans, rodents, pets and some farm animals, but not in horses. The objective of this work was to isolate such cells from the endometrium of mares and to compare their main biological attributes with horse adipose-derived MSCs. Here we successfully isolated and characterized endometrial MSCs (eMSCs) from mares...
October 6, 2017: Theriogenology
https://www.readbyqxmd.com/read/29039226/reconstruction-of-traumatic-dorsal-loss-of-the-thumb-four-different-surgical-approaches
#14
Roberto Adani, Raffaele Mugnai, Giovanna Petrella
BACKGROUND: This article outlines our methods for thumb reconstruction following dorsal skin loss injury located between the metacarpophalangeal joint (MPj) and the entire nail affecting skin, nail, tendon, and bone in different combinations but with intact sensate palmar skin. METHODS: Between 1990 and 2015, 24 patients were treated for dorsal thumb defects using 4 different surgical techniques. Five cases of dorsal compound traumatic loss were reconstructed by custom-made dorsal great toe transfer...
October 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28990099/genome%C3%A2-wide-analysis-and-prediction-of-functional-long-noncoding-rnas-in-osteoblast-differentiation-under-simulated-microgravity
#15
Zebing Hu, Han Wang, Yixuan Wang, Hua Zhou, Fei Shi, Jiangdong Zhao, Shu Zhang, Xinsheng Cao
Long noncoding RNAs (lncRNAs) have been regarded as important regulators in numerous biological processes during cell development. However, the holistic lncRNA expression pattern and potential functions during osteoblast differentiation under simulated microgravity remain unknown. In the present study, a high throughput microarray assay was performed to detect lncRNA and mRNA expression profiles during MC3TC‑E1 pre‑osteoblast cell osteo‑differentiation under simulated microgravity. The expression of 857 lncRNAs and 2,264 mRNAs was signi-ficantly altered when MC3T3‑E1 cells were exposed to simulated microgravity...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28988429/homozygous-indel-mutation-in-cdh11-as-the-probable-cause-of-elsahy-waters-syndrome
#16
Ekim Z Taskiran, Beren Karaosmanoglu, Can Koşukcu, Özlem A Doğan, Hande Taylan-Şekeroğlu, Pelin Ö Şimşek-Kiper, Eda G Utine, Koray Boduroğlu, Mehmet Alikaşifoğlu
Two sisters from a consanguineous couple were seen in genetics department for facial dysmorphic features and glaucoma. They both had broad foreheads, hypertelorism, megalocorneas, thick eyebrows with synophrys, flat malar regions, broad and bulbous noses, and mild prognathism. Both had glaucoma, younger one also had cataracts and phthisis bulbi. Other findings included bilateral partial cutaneous syndactyly of 2nd and 3rd fingers, history of impacted teeth with dentigerous cyst in the elder one, and intellectual disability (mild and borderline)...
December 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28967188/bioactive-nano-fibrous-scaffold-for-vascularized-craniofacial-bone-regeneration
#17
Rahul Damodaran Prabha, David Christian Evar Kraft, Linda Harkness, Birte Melsen, Harikrishna Varma, Prabha D Nair, Jorgen Kjems, Mousthapha Kassem
There has been a growing demand for bone grafts for correction of bone defects in complicated fractures or tumors in the craniofacial region. Soft flexible membrane like material that could be inserted into defect by less invasive approaches; promote osteoconductivity and act as a barrier to soft tissue in growth while promoting bone formation is an attractive option for this region. Electrospinning has recently emerged as one of the most promising techniques for fabrication of extracellular matrix (ECM) like nano-fibrous scaffolds that can serve as a template for bone formation...
October 2, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28962660/local-application-of-igfbp5-protein-enhanced-periodontal-tissue-regeneration-via-increasing-the-migration-cell-proliferation-and-osteo-dentinogenic-differentiation-of-mesenchymal-stem-cells-in-an-inflammatory-niche
#18
Nannan Han, Fengqiu Zhang, Guoqing Li, Xiuli Zhang, Xiao Lin, Haoqing Yang, Lijun Wang, Yangyang Cao, Juan Du, Zhipeng Fan
BACKGROUND: Periodontitis is a widespread infectious disease ultimately resulting in tooth loss. The number of mesenchymal stem cells (MSCs) in patients with periodontitis is decreased, and MSC functions are impaired. Rescuing the impaired function of MSCs in periodontitis is the key for treatment, especially in a manner independent of exogenous MSCs. Our previous study found that overexpressed insulin-like growth factor binding protein 5 (IGFBP5) could promote exogenous MSC-mediated periodontal tissue regeneration...
September 29, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28961672/results-of-retinal-detachment-surgery-in-eyes-with-osteo-keratoprosthesis
#19
Ferran Vilaplana, Jeroni Nadal, José Temprano, Gemma Julio, Rafael I Barraquer
PURPOSE: To evaluate the anatomical and functional results of pars plana vitrectomy in eyes with osteo-keratoprosthesis, who have suffered retinal detachment. METHODS: An observational, retrospective study of 18 eyes which underwent pars plana vitrectomy for retinal detachment after an implantation of an osteo-keratoprosthesis, with a minimum of 1-year follow-up. A descriptive study and a Kaplan-Meier survival analysis for anatomical and functional success were performed...
September 27, 2017: Retina
https://www.readbyqxmd.com/read/28960501/palovarotene-inhibits-connective-tissue-progenitor-cell-proliferation-in-a-rat-model-of-combat-related-heterotopic-ossification
#20
Benjamin M Wheatley, Katherine E Cilwa, Devaveena Dey, Ammar T Qureshi, Jonathan G Seavey, Allison M Tomasino, Erin M Sanders, Wesley Bova, Cynthia A Boehm, Masahiro Iwamoto, Benjamin K Potter, Jonathan A Forsberg, George F Muschler, Thomas A Davis
Heterotopic ossification (HO) develops in the extremities of wounded service members and is common in the setting of high-energy penetrating injuries and blast-related amputations. No safe and effective prophylaxis modality has been identified for this patient population. Palovarotene has been shown to reduce bone formation in traumatic and genetic models of HO. The purpose of this study was to determine the effects of Palovarotene on inflammation, progenitor cell proliferation and gene expression following a blast-related amputation in a rodent model (n = 72 animals), as well as the ability of Raman spectroscopy to detect early HO before radiographic changes are present...
September 28, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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