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https://www.readbyqxmd.com/read/29342438/vitreoretinal-complications-and-outcomes-in-92-eyes-undergoing-surgery-for-modified-osteo-odonto-keratoprosthesis-a-10-year-review
#1
Pukhraj Rishi, Ekta Rishi, Vishvesh Agarwal, Sridevi Nair, Geetha Iyer, Bhaskar Srinivasan, Shweta Agarwal
PURPOSE: To analyze vitreoretinal (VR) complications and treatment outcomes in eyes undergoing modified osteo-odonto-keratoprosthesis (OOKP) surgery. DESIGN: Retrospective case series. PARTICIPANTS: All patients who underwent modified OOKP (mOOKP) surgery at a tertiary eye-care center from March 2003 to February 2013 were included. METHODS: Medical records were reviewed for relevant medical history, best-corrected visual acuity (BCVA), slit-lamp examination, ultrasound scan, oral examination findings, and VR complications...
January 13, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29322320/is-there-a-relationship-between-the-load-distribution-on-the-tibial-plateau-and-hip-knee-ankle-angle-after-tka
#2
Takao Kaneko, Norihiko Kono, Yuta Mochizuki, Hiroyasu Ikegami, Yoshiro Musha
INTRODUCTION: This study asked whether differences in coronal alignment after total knee arthroplasty (TKA) affect the load distribution on the tibial plateau. The aim of this study was to investigate the correlation between coronal alignment and the load distribution on the tibial plateau after TKA, using three-dimensional multi-detector-row-computed tomography (3D-MDCT). MATERIALS AND METHODS: In this study, we performed 84 cementless TKA with porous tantalum modular tibial component (PTMT) and divided into three groups based on post-operative hip-knee-ankle (HKA) angle: varus alignment group (n = 22), (176° ≧) neutral alignment group (n = 45), (180° ± 3°), and valgus alignment group (n = 17) (184° ≦)...
January 10, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29308716/enhanced-antibacterial-property-and-osteo-differentiation-activity-on-plasma-treated-porous-polyetheretherketone-with-hierarchical-micro-nano-topography
#3
Shengnan Wang, Yi Deng, Lei Yang, Xiuyuan Shi, Weizhong Yang, Zhi-Gang Chen
Implantable polyetheretherketone (PEEK) has great biomedical potential as hard tissue substitute in orthopedic application due to its outstanding mechanical properties and excellent biological stability. However, the poor osseointegration and bacteriostatic ability of implantable polyetheretherketone become the major barrier for its wide clinic application. In this study, a hierarchically micro/nano-topographic polyetheretherketone with specific functional groups (amino and COOH/COOR) has been fabricated using facile sulfonation combined with argon plasma treatment...
January 7, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29280610/immunomodulatory-ecm-like-microspheres-for-accelerated-bone-regeneration-in-diabetes-mellitus
#4
Zhiai Hu, Chi Ma, Xin Rong, Shujuan Zou, Xiaohua Liu
Bone repair and regeneration process is markedly impaired in diabetes mellitus (DM) that affects hundreds of millions of people worldwide. As a chronic inflammatory disease, DM creates a pro-inflammatory microenvironment in defective sites. Most of the studies on DM-associated bone regeneration, however, neglect the importance of immuno-modulation in the DM condition and adopt the same approaches to normal bone healing, leading to limited bone healing. In this study, we developed a unique bio-inspired injectable microsphere as an osteo-immunomodulatory biomaterial that modulates macrophages to create a pro-healing microenvironment in the DM condition...
December 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29280510/the-challenges-of-promoting-osteogenesis-in-segmental-bone-defects-and-osteoporosis
#5
REVIEW
Alyssa N Ball, Seth W Donahue, Samantha J Wojda, C Wayne McIlwraith, Christopher E Kawcak, Nicole Ehrhart, Laurie R Goodrich
Conventional clinical management of complex bone healing scenarios continues to result in 5-10% of fractures forming non-unions. Additionally, the aging population and prevalence of osteoporosis related fractures necessitate the further exploration of novel ways to augment osteogenesis in this special population. This review focuses on the current clinical modalities available, and the ongoing clinical and pre-clinical research to promote osteogenesis in segmental bone defects, delayed unions, and osteoporosis...
December 27, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29276737/neural-egf-like-protein-1-nell-1-signaling-crosstalk-in-mesenchymal-stem-cells-and-applications-in-regenerative-medicine
#6
Mikhail Pakvasa, Alex Alverdy, Sami Mostafa, Eric Wang, Lucy Fu, Alexander Li, Leonardo Oliveira, Aravind Athiviraham, Michael J Lee, Jennifer Moriatis Wolf, Tong-Chuan He, Guillermo A Ameer, Russell R Reid
Bone tissue regeneration holds the potential to solve both osteoporosis and large skeletal defects, two problems associated with significant morbidity. The differentiation of mesenchymal stem cells into the osteogenic lineage requires a specific microenvironment and certain osteogenic growth factors. Neural EGF Like-Like molecule 1 (NELL-1) is a secreted glycoprotein that has proven, both in vitro and in vivo, to be a potent osteo-inductive factor. Furthermore, it has been shown to repress adipogenic differentiation and inflammation...
September 2017: Genes & Diseases
https://www.readbyqxmd.com/read/29273059/biomechanical-properties-of-3d-printed-bone-scaffolds-are-improved-by-treatment-with-crfp
#7
Carlos G Helguero, Vamiq M Mustahsan, Sunjit Parmar, Sahana Pentyala, John P Pfail, Imin Kao, David E Komatsu, Srinivas Pentyala
BACKGROUND: One of the major challenges in orthopedics is to develop implants that overcome current postoperative problems such as osteointegration, proper load bearing, and stress shielding. Current implant techniques such as allografts or endoprostheses never reach full bone integration, and the risk of fracture due to stress shielding is a major concern. To overcome this, a novel technique of reverse engineering to create artificial scaffolds was designed and tested. The purpose of the study is to create a new generation of implants that are both biocompatible and biomimetic...
December 22, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29260774/-the-differential-approach-to-the-surgical-treatment-of-pathologies-of-the-frontal-sinus
#8
A M Elovikov, N V Voronchikhina, O A Kubarikova
The surgical intervention for the management of frontal sinusitis is required in a large fraction of patients presenting with this condition. The treatment of choice for the pathology in question is endoscopic endonasal frontotomy. Whenever the endoscopic technique is impossible to employ, the surgeon has to resort to an extranasal operation on the frontal sinus. The indications for the application of such strategy include the pathological conditions complicated by the intracranial and orbital processes, the presence of large benign tumours, recurrent post-surgical purulent sinusitis and traumatic frontal sinusitis...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29249772/inhibition-of-adenosine-monophosphate-activated-protein-kinase-suppresses-bone-morphogenetic-protein-2-induced-mineralization-of-osteoblasts-via-smad-independent-mechanisms
#9
Ayumu Takeno, Ippei Kanazawa, Masakazu Notsu, Ken-Ichiro Tanaka, Toshitsugu Sugimoto
Previous studies showed that adenosine monophosphate-activated protein kinase (AMPK), which plays as an intracellular energy sensor, promotes the differentiation and mineralization of osteoblasts via enhancing expression of bone morphogenetic protein (BMP)-2, which is a potent inducer of osteoblastogenesis. Thus, the aim of this study was to examine the roles of AMPK in BMP-2-induced osteoblastogenesis. We used a murine osteoblastic cell line MC3T3-E1 and a murine marrow stromal cell line ST2. BMP-2 (50 and 100 ng/mL) stimulated alkaline phosphatase (ALP) activity and enhanced mineralization of MC3T3-E1 cells, while the effects of BMP-2 were partly abolished by an inhibitor of AMPK, ara-A (0...
December 16, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29242275/igfbp7-regulates-the-osteogenic-differentiation-of-bone-marrow-derived-mesenchymal-stem-cells-via-wnt-%C3%AE-catenin-signaling-pathway
#10
Wei Zhang, Erman Chen, Mo Chen, Chenyi Ye, Yiying Qi, Qianhai Ding, Hang Li, Deting Xue, Xiang Gao, Zhijun Pan
Insulin-like growth factor-binding protein 7 (IGFBP7), a low-affinity IGF binder, may play an important role in bone metabolism. However, its function in osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (BMSCs) remains unclear. Therefore, we investigated its effects on osteogenic differentiation. Overexpression of IGFBP7 enhanced the expression of osteo-specific genes and proteins, and IGFBP7 knockdown decreased osteogenesis-specific markers. More mineral deposits and higher alkaline phosphatase activity were observed after the up-regulation of IGFBP7 Moreover, β-catenin levels were up-regulated by the overexpression of IGFBP7 or the addition of extracellular IGFBP7 protein and were reduced by the depletion of IGFBP7 The increase in osteogenic differentiation due to the overexpression of IGFBP7 was partially decreased by specific Wnt/β-catenin signaling inhibitors...
December 14, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29235551/interleukin-1%C3%AE-induces-human-cementoblasts-to-support-osteoclastogenesis
#11
Nam C-N Huynh, Vincent Everts, Prasit Pavasant, Ruchanee S Ampornaramveth
Injury of the periodontium followed by inflammatory response often leads to root resorption. Resorption is accomplished by osteoclasts and their generation may depend on an interaction with the cells in direct contact with the root, the cementoblasts. Our study aimed to investigate the role of human cementoblasts in the formation of osteoclasts and the effect of interleukin (IL)-1β hereupon. Extracted teeth from healthy volunteers were subjected to sequential digestion by type I collagenase and trypsin. The effect of enzymatic digestion on the presence of cells on the root surface was analyzed by histology...
December 13, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/29218085/identification-and-differential-expression-of-micrornas-in-1-25-dihydroxyvitamin-d3-induced-osteogenic-differentiation-of-human-adipose-derived-mesenchymal-stem-cells
#12
Huijie Gu, Jun Xu, Zhongyue Huang, Liang Wu, Kaifeng Zhou, Yiming Zhang, Jiong Chen, Jiangni Xia, Xiaofan Yin
The aim of this study was to identify specific microRNAs (miRNAs) and their regulatory roles in the process of 1, 25-dihydroxyvitamin D3-induced (VD3-induced) osteogenic differentiation of human adipose-derived Mesenchymal stem cells (hAMSCs). The differentially expressed miRNAs in VD3-induced hAMSCs was examined. The putative target genes of these miRNAs were predicted. A total of 76 conserved miRNAs, including 18 miRNAs were significantly up-regulated and 58 miRNAs were significantly downregulated, and significantly differentially expressed between the two samples...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29207050/in-vitro-cell-behaviors-of-bone-mesenchymal-stem-cells-derived-from-normal-and-postmenopausal-osteoporotic-rats
#13
Qian Liu, Xiaoxia Zhang, Yang Jiao, Xin Liu, Yirong Wang, Song-Lun Li, Wei Zhang, Fa-Ming Chen, Yin Ding, Chuan Jiang, Zuolin Jin
Postmenopausal osteoporosis (PMO) increases bone fragility and the risk of fractures, and impairs the healing procedure of bone defects in aged women. The stromal cell‑derived factor-1α (SDF-1α)/CXC chemokine receptor type 4 (CXCR4) axis helps to maintain the biological and physiological functions of bone marrow mesenchymal stem cells (BMSCs) and increase the homing efficiency of BMSCs. The present study aimed to provide insights into the possible association between migration and osteogenic ability and the SDF-1α/CXCR4 axis in BMSCs derived from a rat model of PMO...
November 22, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29197342/identification-and-integrated-analysis-of-differentially-expressed-lncrnas-and-circrnas-reveal-the-potential-cerna-networks-during-pdlsc-osteogenic-differentiation
#14
Xiuge Gu, Mengying Li, Ye Jin, Dongxu Liu, Fulan Wei
BACKGROUND: Researchers have been exploring the molecular mechanisms underlying the control of periodontal ligament stem cell (PDLSC) osteogenic differentiation. Recently, long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) were shown to function as competitive endogenous RNAs (ceRNAs) to regulate the effect of microRNAs (miRNAs) on their target genes during cell differentiation. However, comprehensive identification and integrated analysis of lncRNAs and circRNAs acting as ceRNAs during PDLSC osteogenic differentiation have not been performed...
December 2, 2017: BMC Genetics
https://www.readbyqxmd.com/read/29196647/injectable-nanohydroxyapatite-chitosan-gelatin-micro-scaffolds-induce-regeneration-of-knee-subchondral-bone-lesions
#15
B Wang, W Liu, D Xing, R Li, C Lv, Y Li, X Yan, Y Ke, Y Xu, Y Du, J Lin
Subchondral bone has been identified as an attractive target for KOA. To determine whether a minimally invasive micro-scaffolds could be used to induce regeneration of knee subchondral bone lesions, and to examine the protective effect of subchondral bone regeneration on upper cartilage, a ready-to-use injectable treatment with nanohydroxyapatite-chitosan-gelatin micro-scaffolds (HaCGMs) is proposed. Human-infrapatellar-fat-pad-derived adipose stem cells (IPFP-ASCs) were used as a cellular model to examine the osteo-inductivity and biocompatibility of HaCGMs, which were feasibly obtained with potency for multi-potential differentiations...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29188152/astragalus-tuberculosis-a-case-report-and-review-of-the-literature
#16
Yugal Karkhur, Vivek Tiwari, Jeetendra Lodhi, Anurag Tiwari
Osteo-articular tuberculosis continues to be a major global pandemic, with its greatest impact in the third-world countries. Among osteo-articular tuberculosis, plantar localisation, particularly isolated involvement of the talus is an extremely rare event. We discuss the case of a 20-year-old male diagnosed with isolated tuberculosis of right talus without the radiological involvement of the distal tibia, fibula or calcaneum. The diagnosis was made with the help of magnetic resonance imaging and confirmed through core biopsy of the talus...
September 22, 2017: Curēus
https://www.readbyqxmd.com/read/29183822/treatment-of-aseptic-tibial-shaft-non-union-without-bone-defect
#17
REVIEW
M Tall
Non-union is incomplete consolidation of a fracture, without effective formation of a uniting callus. Despite better understanding of the physiology of bone consolidation, management of tibial non-union remains a challenge for orthopedic surgeons. Several treatments have been developed in recent decades, and we now have a range of techniques, with indications based on type of non-union, prior treatments, available equipment, and the surgeon's experience. Firstly, there are surgical techniques such as osteo-periosteal decortication, cancellous iliac graft, or inter-tibiofibular graft...
November 25, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29174872/monteggia-injuries
#18
REVIEW
M Delpont, D Louahem, J Cottalorda
The Monteggia injury is defined as radial head dislocation with a fracture of the ulnar shaft. This combination should be sought routinely in patients with ulnar fractures, even when the displacement is small. The emergent management is simple, as reducing the ulnar fracture is usually sufficient to stabilise the radial head. Internal fixation of the ulna deserves to be widely used to fully stabilise the radial head. Irreducibility of the radial head at the acute stage may indicate an interposition, which requires open surgery on the joint...
November 22, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29171714/biomimetic-materials-and-fabrication-approaches-for-bone-tissue-engineering
#19
REVIEW
Hwan D Kim, Sivashanmugam Amirthalingam, Seunghyun L Kim, Seunghun S Lee, Jayakumar Rangasamy, Nathaniel S Hwang
Various strategies have been explored to overcome critically sized bone defects via bone tissue engineering approaches that incorporate biomimetic scaffolds. Biomimetic scaffolds may provide a novel platform for phenotypically stable tissue formation and stem cell differentiation. In recent years, osteoinductive and inorganic biomimetic scaffold materials have been optimized to offer an osteo-friendly microenvironment for the osteogenic commitment of stem cells. Furthermore, scaffold structures with a microarchitecture design similar to native bone tissue are necessary for successful bone tissue regeneration...
November 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29167844/recellularization-of-decellularized-adipose-tissue-derived-stem-cells-role-of-the-cell-secreted-extracellular-matrix-in-cellular-differentiation
#20
V Guneta, Z Zhou, N S Tan, S Sugii, M T C Wong, C Choong
Adipose-derived stem cells (ASCs) are found in a location within the adipose tissue known as the stem cell niche. The ASCs in the niche are maintained in the quiescent state, and upon exposure to various microenvironmental triggers are prompted to undergo proliferation or differentiation. These microenvironmental triggers also modulate the extracellular matrix (ECM), which interacts with the cells through the cytoskeleton and induces downstream events inside the cells that bring about a change in cell behaviour...
November 23, 2017: Biomaterials Science
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