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https://www.readbyqxmd.com/read/28430334/chondro-keratoprosthesis-an-alternative-to-ookp
#1
Louis Hoffart, Laurent Guyot
PURPOSE: To evaluate the use of cartilage as a potential graft material toward osteo-odontal tissue replacement in keratoprosthesis surgery. METHODS: We describe a modification of the osteo-odonto-keratoprosthesis surgery that involves the use of autologous auricular conchal cartilage graft (ACCG). In stage 1a, a full-thickness cheek mucosa graft was performed over the ocular surface. In stage 1b, ACCG was harvested via a retroauricular approach. An optical polymethyl-methacrylate cylinder was embedded into a double-layered fragment of cartilage and secured by cyanoacrylate glue...
April 4, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28414902/tuning-chemistry-and-topography-of-nanoengineered-surfaces-to-manipulate-immune-response-for-bone-regeneration-applications
#2
Zetao Chen, Akash Bachhuka, Shengwei Han, Fei Wei, Shifeier Lu, Rahul Madathiparambil Visalakshan, Krasimir Vasilev, Yin Xiao
Osteoimmunomodulation has informed the importance of modulating a favorable osteoimmune environment for successful materials-mediated bone regeneration. Nanotopography is regarded as a valuable strategy for developing advanced bone materials, due to its positive effects on enhancing osteogenic differentiation. In addition to this direct effect on osteoblastic lineage cells, nanotopography also plays a vital role in regulating immune responses, which makes it possible to utilize its immunomodulatory properties to create a favorable osteoimmune environment...
April 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28398098/mapk-signaling-has-stage-dependent-osteogenic-effects-on-human-adipose-derived-stem-cells-in-vitro
#3
Eric J Tsang, Benjamin Wu, Patricia Zuk
PURPOSE: The use of pro-osteogenic growth factors, such as BMP2, in human adipose-derived stem cell (ASC) osteogenesis is well described. Because these growth factors work via signal transduction pathways, such as the mitogen-activated protein kinase (MAPK) cascade, a study of the relationship between MAPK signaling and ASC osteogenesis was conducted. METHODS: ERK, JNK, and p38MAPK activation were measured in ASCs osteo-induced using either dexamethasone or vitamin D3 and correlated to mineralization...
April 11, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28394200/alteration-analysis-of-bone-marrow-mesenchymal-stromal-cells-from-de-novo-acute-myeloid-leukemia-patients-at-diagnosis
#4
Laura Desbourdes, Joaquim Javary, Thomas Charbonnier, Nicole Ishac, Jerome Bourgeais, Aurore Iltis, Jean-Claude Chomel, Ali Turhan, Fabien Guilloton, Karin Tarte, Marie-Veronique Demattei, Elfi Ducrocq, Florence Rouleux-Bonnin, Emmanuel Gyan, Olivier Hérault, Jorge Domenech
Bone marrow (BM)-derived mesenchymal stromal cells (MSCs) frequently display alterations in several hematologic disorders, such as acute lymphoid leukemia, acute myeloid leukemia (AML), and myelodysplastic syndromes. In acute leukemias, it is not clear whether MSC alterations contribute to the development of the malignant clone or whether they are simply the effect of tumor expansion on the microenvironment. We extensively investigated the characteristics of MSCs isolated from the BM of patients with de novo AML at diagnosis (L-MSCs) in terms of phenotype (gene and protein expression, apoptosis and senescence levels, DNA double-strand break formation) and functions (proliferation and clonogenic potentials, normal and leukemic hematopoiesis-supporting activity)...
April 10, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28365680/pro-inflammatory-cytokine-tnf-%C3%AE-attenuates-bmp9-induced-osteo-odontoblastic-differentiation-of-the-stem-cells-of-dental-apical-papilla-scaps
#5
Feilong Wang, Ying Jiang, Xia Huang, Qiao Liu, Yan Zhang, Wenping Luo, Fugui Zhang, Pengfei Zhou, Juhong Lin, Hongmei Zhang
BACKGROUND/AIMS: Periapical periodontitis is a common oral disease caused by bacterial invasion of the tooth pulp, which usually leads to local release of pro-inflammatory cytokines and osteolytic lesion. This study is intended to examine the effect of TNF-α on BMP9-induced osteogenic differentiation of the stem cells of dental apical papilla (SCAPs). METHODS: Rat model of periapical periodontitis was established. TNF-α expression was assessed. Osteogenic markers and ectopic bone formation in iSCAPs were analyzed upon BMP9 and TNF-α treatment...
March 31, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28356217/growth-and-accelerated-differentiation-of-mesenchymal-stem-cells-on-graphene-oxide-coated-titanate-with-dexamethasone-on-surface-of-titanium-implants
#6
Na Ren, Jianhua Li, Jichuan Qiu, Mei Yan, Haiyun Liu, Dandan Ji, Jiadong Huang, Jinghua Yu, Hong Liu
OBJECTIVE: In this study, the objective is to construct graphene-oxide-coated titanate on titanium foils as drug vehicle to enhance cell proliferation and osteo-differentiation of rat bone mesenchymal stem cells (rBMSCs). METHODS: Graphene oxide (GO) sheets obtained using the modified Hummer's method and characterized by AFM were coupled with bioactive titanate on Ti implants (GO-Ti) pretreated by alkali, followed by reduction (rGO-Ti). They were characterized by Raman spectroscopy, XPS, SEM, FTIR and contact angle...
March 26, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28350456/starch-derived-nanographene-oxide-paves-the-way-for-electrospinnable-and-bioactive-starch-scaffolds-for-bone-tissue-engineering
#7
Duo Wu, Archana Samanta, Rajiv K Srivastava, Minna Hakkarainen
A straightforward process that enabled electrospinning of bioactive starch-based nanofiber scaffolds was developed by utilizing starch derived nano graphene oxide (nGO) as a property enhancer and formic acid as a solvent and esterification reagent. The reaction mechanism and process were followed by detailed spectroscopic investigation. Furthermore, the incorporation of nGO as a "green bioactive additive" endorsed starch nanofibrous scaffolds several advantageous functionalities including improved electrospinnability and thermal stability, good cytocompatibility, osteo-bioactivity, and retained biodegradability...
March 31, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28342024/towards-optimization-of-odonto-osteogenic-bioengineering-in-vitro-comparison-of-simvastatin-sodium-fluoride-melanocyte-stimulating-hormone
#8
Vahid Zijah, Roya Salehi, Marziyeh Aghazadeh, Mohammad Samiei, Effat Alizadeh, Soodabeh Davaran
Tissue engineering has emerged as a potential therapeutic option for dental problems in recent years. One of the policies in tissue engineering is to use both scaffolds and additive factors for enhancing cell responses. This study aims to evaluate and compare the effect of three types of biofactors on poly-caprolactone-poly-ethylene glycol-poly caprolactone (PCL-PEG-PCL) nanofibrous scaffold on human dental pulp stem cell (hDPSCs) engineering. The PCL-PEG-PCL copolymer was synthesized with ring opening polymerization method, and its nanofiber scaffold was prepared by electrospinning method...
March 25, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28339395/effect-of-ovariectomy-and-sideritis-euboea-extract-administration-on-large-artery-mechanics-morphology-and-structure-in-middle-aged-rats
#9
Dimitrios P Sokolis, Constantinos A Dimitriou, Pavlos Lelovas, Nikolaos G Kostomitsopoulos, Ismene A Dontas
BACKGROUND: Arterial function is regulated by estrogen, but no consistent pattern of arterial mechanical remodeling in response to depleted estrogen levels is available. OBJECTIVE: To examine long-term effects of ovariectomy (OVX) on the mechanical properties, morphology, and histological structure of carotid artery in middle-aged rats and a potentially protective effect of Sideritis euboea extract (SID), commonly consumed as "mountain tea". METHODS: 10-month-old female Wistar rats were allocated into control (sham-operated), OVX, OVX+SID, and OVX+MALT (maltodextrin; excipient used for dilution of SID) groups...
March 20, 2017: Biorheology
https://www.readbyqxmd.com/read/28332281/collagen-type-xv-and-the-osteogenic-status
#10
Gina Lisignoli, Elisabetta Lambertini, Cristina Manferdini, Elena Gabusi, Letizia Penolazzi, Francesca Paolella, Marco Angelozzi, Veronica Casagranda, Roberta Piva
We have previously demonstrated that collagen type XV (ColXV) is a novel bone extracellular matrix (ECM) protein. It is well known that the complex mixture of multiple components present in ECM can help both to maintain stemness or to promote differentiation of stromal cells following change in qualitative characteristics or concentrations. We investigated the possible correlation between ColXV expression and mineral matrix deposition by human mesenchymal stromal cells (hMSCs) with different osteogenic potential and by osteoblasts (hOBs) that are able to grow in culture medium with or without calcium...
March 22, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28329888/osteo-odonto-keratoprosthesis-in-severe-ocular-graft-versus-host-disease
#11
K Plattner, D Goldblum, J Halter, C Kunz, R Koeppl, N Gerber-Hollbach
No abstract text is available yet for this article.
March 22, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28294517/osteogenic-differentiation-of-mesenchymal-stem-cells-using-hybrid-nanofibers-with-different-configurations-and-dimensionality
#12
D Gugutkov, F Awaja, K Belemezova, M Keremidarska, N Krasteva, S Kuyrkchiev, G GallegoFerrer, S Seker, A E Elcin, Y M Elcin, G Altankov
Novel hybrid, fibrinogen/polylactic acid (FBG/PLA) nanofibers with different configuration (random vs. aligned) and dimensionality (2D vs.3D environment) were used to control the overall behaviour and the osteogenic differentiation of human Adipose Derived Mesenchymal Stem Cells (ADMSCs). Aligned nanofibers in both the 2D and 3D configurations are proved to be favoured for osteo-differentiation. Morphologically we found that on randomly configured nanofibers, the cells developed a stellate-like morphology with multiple projections, however, time-lapse analysis showed significantly diminished cell movements...
March 11, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28293492/a-rare-case-of-malignant-transformation-of-oral-lichen-planus-of-the-mandible
#13
Joanne Soo, George Kokosis, Michael Ogilvie, Xiaoyin Sara Jiang, David B Powers, Daniel J Rocke, Detlev Erdmann
Oral lichen planus (OLP) is an immune-mediated mucocutaneous disease associated with an increased risk in oral squamous cell carcinoma (OSCC). Nearly all cases of malignant transformation have been reported in patients >40 years old. We report the case of a 37-year-old woman with a 5-year history of erosive OLP who presented with malignant transformation to OSCC. Delineating the margins of the disease was impossible at presentation given her OLP, and she was initially treated with concurrent chemoradiation therapy...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28285576/decellularized-bone-extracellular-matrix-and-human-dental-pulp-stem-cells-as-a-construct-for-bone-regeneration
#14
Francesco Paduano, Massimo Marrelli, Noura Alom, Mahetab Amer, Lisa J White, Kevin M Shakesheff, Marco Tatullo
Dental pulp tissue represents a source of mesenchymal stem cells that have a strong differentiation potential towards the osteogenic lineage. The objective of the current study was to examine in vitro osteogenic induction of dental pulp stem cells (DPSCs) cultured on hydrogel scaffolds derived from decellularized bone extracellular matrix (bECM) compared to collagen type I (Col-I), the major component of bone matrix. DPSCs in combination with bECM hydrogels were cultured under three different conditions: basal medium, osteogenic medium and medium supplemented with growth factors (GFs) and cell growth, mineral deposition, gene and protein expression were investigated...
March 13, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28259801/effect-of-tetrahedral-dna-nanostructures-on-osteogenic-differentiation-of-mesenchymal-stem-cells-via-activation-of-the-wnt-%C3%AE-catenin-signaling-pathway
#15
Xiao-Ru Shao, Shi-Yu Lin, Qiang Peng, Si-Rong Shi, Xiao-Long Li, Tao Zhang, Yun-Feng Lin
Adipose-derived stem cells (ADSCs) are considered to be ideal stem cell sources for bone regeneration owing to their ability to differentiate into osteo-like cells. Therefore, they have attracted increasing attention in recent years. Tetrahedral DNA nanostructures (TDNs), a new type of DNA-based biomaterials, have shown great potential for biomedical applications. In the present work, we aimed to investigate the role played by TDNs in osteogenic differentiation and proliferation of ADSCs and tried to explore if the canonical Wnt signal pathway could be the vital biological mechanism driving these cellular responses...
March 1, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28254309/osteo-growth-induction-titanium-surface-treatment-reduces-ros-production-of-mesenchymal-stem-cells-increasing-their-osteogenic-commitment
#16
Paolo Ghensi, Eriberto Bressan, Chiara Gardin, Letizia Ferroni, Lucio Ruffato, Mauro Caberlotto, Claudio Soldini, Barbara Zavan
Surface characteristics play a special role for the biological performance of implants and several strategies are available to this end. The OGI (Osteo Growth Induction) titanium surface is a surface, obtained by applying a strong acid onto the blasted surface. The aim of this in-vitro study is to evaluate in vitro the osteoproperties of OGI surfaces on Mesenchymal Stem cells derived from dental pulp. Our results confirm that this treatment exert a positive effect on mitochondrial homeostasis, as shown by a decrease in ROS production related to environmental stress on the mitochondria...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28246532/canine-adipose-derived-mesenchymal-stem-cells-transcriptome-composition-alterations-a-step-towards-standardizing-therapeutic
#17
Nina Krešić, Ivana Šimić, Ivana Lojkić, Tomislav Bedeković
Although canine adipose derived stem cells (cASCs) morphology characteristics and differentiation ability are well documented, transcriptome alterations of undifferentiated cASCs during ex vivo cultivation remain unknown. Here we demonstrate, for the first time, the transcriptome composition of isolated cASCs in undifferentiated state originating from six donors. Transcriptome changes were monitored during ex vivo cultivation between passage 3 (P3) and P5, which are mostly used in therapy. Influence of donors' age in given passage number on transcriptome composition was also investigated...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28240263/mir-21-deficiency-inhibits-osteoclast-function-and-prevents-bone-loss-in-mice
#18
Cheng-Hu Hu, Bing-Dong Sui, Fang-Ying Du, Yi Shuai, Chen-Xi Zheng, Pan Zhao, Xiao-Rui Yu, Yan Jin
MicroRNAs emerge as critical post-transcriptional regulators in bone metabolism. We have previously reported in vitro that miR-21 promotes osteogenesis, while studies have also revealed miR-21 as a regulator of osteoclastogenesis and a promoter of osteoclast differentiation in vitro. However, in vivo data are still lacking in identifying skeletal function of miR-21, particularly its effects on osteoporosis. Here, using miR-21 knockout (miR-21(-/-)) mice, we investigated effects of miR-21 on bone development, bone remodeling and bone loss...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28217237/-caught-by-the-eye-of-sound-epigastric-swelling-due-to-xiphisternal-tuberculosis
#19
Shabnam Bhandari Grover, Sumit Arora, Amit Kumar, Hemal Grover, Amit Katyan, Deepthi Mohan Nair
BACKGROUND: Common causes of an epigastric mass include hepatomegaly, pancreatic pseudocyst and epigastric hernia, less common causes being carcinoma of the stomach or pancreas, whereas diseases of the sternum presenting as an epigastric swelling is extremely uncommon. We report a case of tubercular infection of the sternum located in the xiphoid process resulting in its presentation as an epigastric swelling. CASE REPORT: A 30-year-old immunocompetent woman with complaints of an epigastric swelling and undocumented pyrexia for four months was referred for sonographic evaluation with a clinical suspicion of an incompletely treated liver abscess...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28185669/electrical-stimulation-and-monitoring-devices-of-the-cns-an-imaging-review
#20
REVIEW
Sohil H Patel, Casey H Halpern, Timothy M Shepherd, Vincent M Timpone
Functional neurosurgery is a rapidly growing field with exciting future potential applications. This article describes currently used implanted electronic devices for neurologic stimulation and monitoring. The devices to be reviewed include invasive EEG electrodes, deep brain stimulator, motor cortex stimulator, responsive neurostimulation, osteo-integrated hearing aid, middle ear implant, cochlear implant, auditory brainstem implant, vagal nerve stimulator and spinal cord stimulator. Emphasis is placed on the normal components, function, positioning, potential complications and MRI safety of these devices...
February 6, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
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