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Rachel M Nygaard, Frederick W Endorf
Numerous demographic, socioeconomic, and injury factors influence a burn patient's hospital course. Compared to the typical burn patient, frostbite injury frequently impacts those with high rates of mental illness, substance abuse, and those suffering homelessness. Our aim was to examine differences in the hospital course of frostbite patients compared to those with burns limited to the hands and feet. Patients with frostbite injury and those with isolated hand and/or foot burns were identified in the National Burn Repository...
June 15, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
Yuma Nonomiya, Takashi Yokokawa, Kazuyoshi Kawakami, Kazuo Kobayashi, Takeshi Aoyama, Tomomi Takiguchi, Takahito Sugisaki, Kenichi Suzuki, Mitsukuni Suenaga, Takeru Wakatsuki, Kensei Yamaguchi, Yoshikazu Sugimoto, Toshihiro Hama
Regorafenib is a multikinase inhibitor for the treatment of metastatic colorectal cancer. Regorafenib-induced hand-footskin reaction (HFSR) is a common side effect during treatment. The reported frequency of HFSR was 80% (Grade 3: 28%) of the Japanese subpopulation in the CORRECT trial; however, more detailed data regarding HFSR in terms of onset and sites of susceptibility are unclear. Additionally, the risk factors for regorafenib-induced severe HFSR are unknown. The aim of this study was to compare HFSR between the hands and feet and identify pre-existing risk factors for severe HFSR in Japanese patients receiving regorafenib...
June 18, 2018: Oncology Research
Nguyen Thi Mai Huong, Nguyen Thi Kim Lien, Ngo Diem Ngoc, Nguyen Thi Phuong Mai, Nguyen Pham Anh Hoa, Le Thanh Hai, Phan Van Chi, Ta Thanh Van, Tran Van Khanh, Nguyen Huy Hoang
BACKGROUND: Wilson disease (OMIM # 277900) is a autosomal recessive disorder characterized by accumulation of copper in liver and brain. The accumulation of copper resulting in oxidative stress and eventually cell death. The disease has an onset in a childhood and result in a significant neurological impairment or require lifelong treatment. Another serious consequence of the disease is the development of liver damage and acute liver failure leading to liver transplant. The disorder is caused by mutations in the ATP7B gene, encoding a P-type copper transporting ATPase...
June 18, 2018: BMC Medical Genetics
Hiroshi Kuge, Hidetoshi Mori, Tateyuki Morisawa, Kazuyo Hanyu, Junji Miyazaki, Mayumi Watanabe, Tim Hideaki Tanaka
Background: Indirect moxibustion (IM) has been previously performed between the spinous process while recording skin temperature of the trunk. However, moxibustion is often applied not only to acupuncture points on the back, but also to points located on the limbs. Thus, there is a need to investigate skin temperature (ST) responses following IM applied to the limbs. Methods: In Experiment 1 (Exp 1), subjects were randomly assigned to three groups: the left IM stimulation, right IM stimulation and control groups...
June 15, 2018: Medicines (Basel, Switzerland)
Marianne Rørbæk, Lise Ventzel, Hanne Gottrup
Background Neuropathic pain is usually treated with antidepressants and anticonvulsant. The use of systemic treatment is, however, limited due to poor tolerability and low efficacy. Qutenza, a topical capsaicin patch (8%), is a relatively new treatment for patients with peripheral neuropathic pain (PNP) conditions. The indication for using topical capsaicin treatment is peripheral neuropathic pain in patients without diabetes. Aim To describe the use of topical capsaicin treatment in a pain clinic in patients with PNP...
December 29, 2017: Scandinavian Journal of Pain
Kenneth Geving Andersen, Maj-Britt Jensen, Henrik Kehlet, Rune Gärtner, Lise Eckhoff, Niels Kroman
Background Persistent pain after breast cancer treatment (PPBCT) is a considerable clinical problem affecting between 25 and 60% of breast cancer survivors [1]. Several risk factors have been proposed, among them nerve damage caused by adjuvant treatment [2]. Taxanes used in adjuvant therapy for breast cancer are neurotoxic, and thereby being a potential risk factor for PPBCT and sensory disturbances. However, the long term influence of taxanes on PPBCT is not well documented. Thus, the aim of this study was therefore to compare a nationwide cohort treated with cyclophosphamide and epirubicin + docetaxel (CE + T) versus a nationwide cohort treated with cyclophosphamide, epirubicin and fluoruracil (CEF), in order to assess differences in reporting of PPBCT, sensory disturbances in surgical area, symmetric peripheral sensory disturbances, and functional impairment...
December 29, 2017: Scandinavian Journal of Pain
Daniel W W Heitzmann, Firooz Salami, Alan R De Asha, Julia Block, Cornelia Putz, Sebastian I Wolf, Merkur Alimusaj
BACKGROUND: Individuals with trans-tibial amputation show a greater peak prosthetic ankle power (push- off) when using energy storing and returning (ESAR) prosthetic feet as compared to solid-ankle cushion-heel feet. ESAR feet further contribute to the users' body support and thus limit prosthetic ankle motion. To improve ankle motion, articulating prosthetic feet have been introduced. However, articulating feet may diminish push-off. RESEARCH QUESTION: Does a novel prosthetic foot, with a serial layout of carbon fibre leaf springs, connected by a multi-centre joint construction, have advantages in kinematics and kinetics over a conventional ESAR prosthetic foot?> METHODS: Eleven individuals with unilateral trans-tibial amputation were fitted with the novel foot (NF) and a conventional ESAR Foot (CF) and underwent 3D gait analysis...
June 11, 2018: Gait & Posture
Ignacio Sanpera, Guillem Frontera-Juan, Julia Sanpera-Iglesias, Laura Corominas-Frances
Background and purpose - Pes cavovarus (PCV) is a complex deformity, frequently related to neurological conditions and associated with foot pain, callosities, and walking instability. The deformity has the tendency to increase during growth. Orthotic treatment is ineffective and surgery may be troublesome. We present the preliminary results of a new mini-invasive surgical technique for correction of this foot deformity. Patients and methods - We operated on 13 children (24 feet), age 7-13 years. In 7 children the deformity was neurological in origin...
June 18, 2018: Acta Orthopaedica
Zhiping Zhang, Martin Schmelz, Märta Segerdahl, Hans Quiding, Carina Centerholt, Anna Juréus, Thomas Hedley Carr, Jessica Whiteley, Hugh Salter, Mari Skylstad Kvernebo, Kristin Ørstavik, Tormod Helås, Inge-Petter Kleggetveit, Lars Kristian Lunden, Ellen Jørum
Background and aim "Gain-of-function" mutations in voltage-gated sodium channel NaV1.7 have been linked to erythromelalgia (EM), characterized by painful hot and red hands and feet. We investigated the proportion of patients with EM that carry a mutation in NaV1.7 or in other pain-related genes and studied possible clinical differences. Methods In this study, 48 patients with EM were screened for mutations in a total of 29 candidate genes, including all sodium channel subunits, transient receptor potential channels (TRPA1, TRPV1, TRPM8), neurotrophic factors (NGF, NGFR, BDNF, GDNF, NTRK1 and WNK1) and other known pain-related genes (CACNG2, KCNS1, COMT, P2RX3, TAC1, TACR1), using a combination of next generation sequencing and classical Sanger sequencing...
December 29, 2017: Scandinavian Journal of Pain
Yung-Lien Lai, Chuen-Jim Sheu, Yi-Fen Lu
Although numerous public closed-circuit television (CCTV) initiatives have been implemented at varying levels in Taiwan's cities and counties, systematic evaluations of these crime reduction efforts have been largely overlooked. To address this void, a quasi-experimental evaluation research project was designed to assess the effect of police-monitored CCTV on crime reduction in Taipei City for a period of 54 months, including data for both before and after camera installation dates. A total of 40 viewsheds within a 100-m (328 feet) radius were selected as research sites to observe variations in four types of crime incidents that became known to police during the January 2008 to June 2012 period...
June 1, 2018: International Journal of Offender Therapy and Comparative Criminology
Rajesh Malhotra, Deepak Gautam, Bhavuk Garg, Anjan Trikha
We wish to present a case of 47-year-old patient with Juvenile Rheumatoid Arthritis and ankylosis of both hips and both knees treated by bilateral hip and knee arthroplasty in a single anaesthesia i.e. Quadruple joint replacement in single sitting. He was back on his feet from his bed-ridden state within the fortnight following surgery. He has been followed up for four years and has been performing his activities of daily living independently. We discuss the preoperative planning, surgical details and post-operative rehabilitation and unique challenges pertaining to this case...
May 2018: Archives of Bone and Joint Surgery
Shelain Patel, Parag Garg, M Ali Fazal, Muhammad S Shahid, Derek H Park, Pinak S Ray
BACKGROUND: The reverse camber shoe is commonly used after hallux valgus corrective surgery to offload the forefoot but is associated with back pain and poor compliance. Recent designs of postoperative shoes may obviate the need for a reverse camber. The purpose of this study was to compare the effects of a reverse camber shoe and a noncambered shoe with transitional rigidity after hallux valgus correction. METHODS: A cohort of 80 feet was prospectively studied undergoing surgery at a single NHS trust...
June 1, 2018: Foot & Ankle Specialist
Alberto Cauli, Dafna D Gladman, Alessandro Mathieu, Ignazio Olivieri, Giovanni Porru, Paul P Tak, Claudia Sardu, Raffaele Scarpa, Antonio Marchesoni, William J Taylor, Carlo Salvarani, Joachim Kalden, Ennio Lubrano, Sueli Carneiro, Matteo Piga, Alberto Floris, Francesca Desiati, John A Flynn, Salvatore D'Angelo, Arno W R van Kuijk, Maria Grazia Catanoso, Francesco Caso, Paolo Contu, Ilona Ujfalussy, Philip S Helliwell, Philip J Mease
OBJECTIVE: Physician's global assessment (PGA) of disease activity is a major determinant of therapeutic decision making. This study assesses the reliability of the PGA, measured by means of 0-100 mm visual analog scale (VAS), and the additional use of separate VAS scales for musculoskeletal (PhysMSK) and dermatologic (PhysSk) manifestations in patients with psoriatic arthritis (PsA). METHODS: Sixteen centers from 8 countries enrolled 319 consecutive patients with PsA...
June 15, 2018: Journal of Rheumatology
Borja Martinez-Tellez, Lourdes Ortiz-Alvarez, Guillermo Sanchez-Delgado, Huiwen Xu, Francisco M Acosta, Elisa Merchan-Ramirez, Victoria Muñoz-Hernandez, Wendy D Martinez-Avila, Miguel A Contreras-Gomez, Angel Gil, Idoia Labayen, Jonatan R Ruiz
BACKGROUND & AIM: The thermic effect of food (TEF) refers to the increase of the metabolic rate and body temperature in response to a single meal. To date, most of the studies have focused to determine the TEF in terms of energy expenditure, but little is known about which is the response in terms of skin temperature. The aim of this study was to analyze whether the thermic effect of food (TEF) on the skin temperature with a standardized and individualized liquid meal test is different in young adult men than in young adult women...
June 2, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Monica Rosales Santillan, Jessica B Dietert, Richard Jahan-Tigh
Papular purpuric gloves and socks syndrome (PPGSS) is a self-limited exanthem that presents as painful or pruritic edema, erythema, petechiae, and purpura of the palms and soles with occasional extension to the dorsal hands and feet. The majority of PPGSS cases reported in the literature are associated with parvovirus B19 and occur in children and young adults. In a recent literature search, there were 11 PPGSS cases in adults with none reporting Epstein-Barr virus (EBV) as a viral etiology. However, there have been PPGSS cases related to EBV in children...
April 15, 2018: Dermatology Online Journal
Mohammad J Alkhatatbeh, Khalid K Abdul-Razzak, Lubna Q Khasawneh, Nesreen A Saadeh
The aim of the present study was to investigate the prevalence of musculoskeletal pain in patients with type 2 diabetes mellitus (T2DM) in association with 25-hydroxyvitamin D levels, anxiety, depression and neuropathy. A cross-sectional study was conducted involving a total of 124 T2DM patients. Musculoskeletal pain was determined by self-reporting of painful body sites. Pain intensity was assessed using a scale of 0-10. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale. Neuropathy was assessed using the PainDETECT questionnaire...
June 2018: Biomedical Reports
Shang-Lin Chiang, Chueh-Ho Lin, Yaw-Don Hsu, Shun-Hwa Wei, Wen-Hsu Sung, Liang-Hsuan Lu, Shin-Tsu Chang, Tsung-Yen Ho, Yu-Ping Shen, Liang-Cheng Chen, Chia-Huei Lin
BACKGROUND AND OBJECTIVE: Parkinson's disease (PD) is a neurodegenerative condition characterized by motor dysfunction and various types of non-motor impairments. The reaction time and movement time are reported to become more severe delayed in worse PD patients. Most tools for evaluating motor impairment are limited by relying on subjective observations and being qualitative in design. The aim of this study was to investigate trunk rolling performance in PD patients by using a recently developed system to detect turning in bed...
August 2018: Computer Methods and Programs in Biomedicine
Rosangela Alice Batistela, Alison Oates, Renato Moraes
Understanding the effects of haptic input while performing a cognitive-visual task on postural control can broaden comprehension of the functional integration hypothesis in older adults with and without a history of falls. We aimed to investigate the effect of haptic input provided by light touch (LT) and the anchors while performing a cognitive-visual task in faller and non-faller older adults when standing upright. Twenty-two fallers and twenty-two non-fallers older adults participated in this study. They stood upright with feet together and performed six experimental conditions combining haptic cues (none, LT, and anchors) and the presence/absence of the cognitive-visual task (the adapted visual Stroop test)...
June 11, 2018: Human Movement Science
Antoine Josse, Bernard Fraisse, Sylvette Marleix, Catherine Tréguier, Servane Le Lez Soquet, Kamal Chouklati, Pierre Darnault, Marianne Roche, Grégory Lucas, Philippe Violas
BACKGROUND: At birth, clinical classifications are the only available tools for evaluating the severity of congenital clubfoot. Ultrasound provides an assessment of the anatomical abnormalities. The objective of this study was to assess correlations between physical and ultrasound findings at birth. HYPOTHESIS: Physical and ultrasonography provide different findings in congenital clubfoot and should therefore be used in conjunction. MATERIAL AND METHOD: 145 clubfeet in 108 patients born between 2006 and 2010 were included in a retrospective study...
June 11, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
Ana Francisca Rozin Kleiner, Aline de Souza Pagnussat, Camila Pinto, Ritchele Rovido, Ana Paula Salazar, Manuela Galli
OBJECTIVE: to assess the effects of Automated Peripheral Stimulation (AMPS) in reducing gait variability of subjects with Parkinson's Disease (PD) and freezing of gait (FOG) treated with AMPS and to explore the effects of this treatment on gait during a single task (walking) and a dual task (walking while attending the word-color Stroop test). DESIGN: interventional, double-blinded, placebo-controlled, randomized trial. SETTING: Clinical rehabilitation...
June 11, 2018: Archives of Physical Medicine and Rehabilitation
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