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https://www.readbyqxmd.com/read/29029341/an-increased-concentration-of-receptor-activator-of-nuclear-factor-kappa-b-ligand-pre-dates-the-onset-of-rheumatoid-arthritis
#1
Linda Johansson, Lisbeth Ärlestig, Heidi Kokkonen, Mikael Brink, Solbritt Rantapää-Dahlqvist
Objectives: RANK ligand (RANKL) is involved in destruction and osteoporosis in RA. In this study, the relationships between RANKL and ACPA, anti-carbamylated protein antibodies (anti-CarP), cytokines and chemokines were analysed in individuals before the onset of RA symptoms, and their associations with radiological findings at disease onset were assessed. Methods: This was a case-control study performed within the Medical Biobank of Northern Sweden that included 470 pre-symptomatic individuals [334 women and 136 men; mean (s...
September 25, 2017: Rheumatology
https://www.readbyqxmd.com/read/29029147/maternal-and-fetal-outcomes-among-pregnant-women-with-human-monkeypox-infection-in-the-democratic-republic-of-congo
#2
Placide K Mbala, John W Huggins, Therese Riu-Rovira, Steve M Ahuka, Prime Mulembakani, Anne W Rimoin, James W Martin, Jean-Jacques T Muyembe
Human monkeypox is an endemic disease in rain-forested regions of central Democratic Republic of Congo. We report fetal outcomes for 1 of 4 pregnant women who participated in an observational study at the General Hospital of Kole (Sankuru Province), where 222 symptomatic subjects were followed between 2007 and 2011. Of the 4 pregnant women, 1 gave birth to a healthy infant, 2 had miscarriages in the first trimester, and 1 had fetal death, with the macerated stillborn showing diffuse cutaneous maculopapillary skin lesions involving the head, trunk and extremities, including palms of hands and soles of feet...
October 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29028076/intestinal-probiotics-in-relieving-clinical-symptoms-of-severe-hand-foot-and-mouth-disease-and-potential-mechanism-analysis
#3
F Zhu, Z Jiang, H-W Li
OBJECTIVE: In this prospective cohort study, the efficacy and action mechanism of an intestinal probiotic formulation, Golden Bifid, in severe hand, foot, and mouth disease (HFMD) were determined in 63 consecutively admitted patients successfully treated in the Pediatrics Emergency Department of our hospital. PATIENTS AND METHODS: All patients had a persistent fever; 43 patients had rashes on hands, feet, crissum, and hips; and 45 patients had neurological signs and symptoms...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29024959/limb-laterality-recognition-score-a-reliable-clinical-measure-related-to-phantom-limb-pain
#4
Christopher Kevin Wong, Caitlin Kimberly Wong
Objective: To explore the usefulness of the limb laterality recognition score as a clinical measure of phantom limb pain, regarding test-retest reliability and association of limb laterality recognition scores with phantom limb pain measures. Design: Retrospective cohort. Setting: Community support group. Subjects: Eleven adults who averaged 4.8 years since lower limb amputation due to vascular pathologies (N = 9), trauma (N = 1), and cancer (N = 1)...
August 24, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29024511/the-relationship-between-linear-osteological-and-radiographic-measurements-of-the-human-calcaneus-and-talus
#5
David Agoada
Plain radiographs of the foot are a common form of examination in individuals when medical evaluation is indicated. Their availability makes them useful for studying human variation where large sample sizes are crucial. Calcaneal and talar morphology are critical in the understanding of human foot form and function, but few studies have examined the accuracy of linear measurements of these bones taken from radiographs. If linear measurements are to be used in quantitative analysis, their accuracy must first be demonstrated...
October 10, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29024479/partite-hallux-sesamoid-bones-relationship-with-sesamoid-bones-at-other-metatarsophalangeal-joints
#6
Tao Sun, Haitao Zhao, Lingxiang Wang, Wenjuan Wu
Introduction - Partite hallux sesamoids are clinically meaningful but their association with other sesamoids is not clear. The objective was to relate the prevalence of the partite hallux sesamoid bones to sesamoid bones at other metatarsophalangeal (MTP) joints. Methods - We conducted a retrospective review of plain radiographs of 7946 adult feet between November 2005 and September 2012 in order to identify partite hallux sesamoids and sesamoids at other MTP joints. Coexistence patterns of the partition and extra sesamoids were studied...
October 10, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29023846/locomotor-and-skeletal-muscle-abnormalities-in-trembler-j-neuropathic-mice
#7
Darin J Falk, Tori Galatas, Adrian G Todd, Elliott P Soto, Andrew B Harris, Lucia Notterpek
INTRODUCTION: Patients with hereditary peripheral neuropathies exhibit characteristic deformities of the hands and feet and have difficulty ambulating. To examine to what extent neuropathic animals recapitulate these deficits, we studied Trembler J mice, which model early-onset demyelinating neuropathy. METHODS: A cohort of 4-month old female wild type and neuropathic mice were evaluated for locomotor measurements, neuromuscular function and skeletal muscle proteolysis and morphometry...
October 12, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29023701/identification-of-novel-homozygous-slurp1-mutation-in-a-javanese-family-with-mal-de-meleda
#8
Sunardi Radiono, Zacharias A D Pramono, Glenda G K Oh, Uttam Surana, Syahfori Widiyani, Retno Danarti
BACKGROUND: Mal de Meleda (OMIM# 248300; keratosis palmoplantaris transgrediens) is an autosomal recessive form of palmoplantar keratoderma, clinically characterized by sharp demarcated erythema and hyperkeratosis of the palms and soles that progress with age and extend to the dorsal aspects of the hands and feet. The mal de Meleda is caused by mutations in the SLURP1 gene that encodes secreted lymphocyte antigen 6/urokinase-type plasminogen receptor-related protein 1 (SLURP1). To date no reported cases from Indonesia...
November 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29023680/first-direct-evidence-of-involvement-of-a-homozygous-loss-of-function-variant-in-the-eps15l1-gene-underlying-split-hand-split-foot-malformation
#9
Muhammad Umair, Asmat Ullah, Safdar Abbas, Farooq Ahmad, Sulman Basit, Wasim Ahmad
Split-hand/split-foot malformation (SHFM) is a severe form of congenital limb deformity characterized by the absence of one or more digits and/or variable degree of median clefts of hands and feet. The present study describes an investigation of a consanguineous family of Pakistani origin segregating SHFM in an autosomal recessive manner. Human genome scan using SNP markers followed by whole exome sequencing revealed a frameshift deletion (c.409delA, p.Ser137Alafs*19) in the EPS15L1 gene located on chromosome 19p13...
October 10, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/29022192/a-positive-circuit-of-vegf-increases-glut-1-expression-by-increasing-hif-1%C3%AE-gene-expression-in-human-retinal-endothelial-cells
#10
Yoon Kyung Choi
Treatment of human retinal microvascular endothelial cells (HRMECs) with vascular endothelial growth factor 165 (VEGF165) increased hypoxia-inducible factor 1α (HIF-1α), VEGF, and glucose transporter 1 (Glut-1) mRNA expression and Glut-1 protein localization to the membrane. In contrast, treatment of human retinal pigment epithelium cells with VEGF165 did not induce HIF-1α, VEGF, and Glut-1 gene expression. Microvascular endothelial cells are surrounded by astrocytic end feet in the retina. Astrocyte-derived A-kinase anchor protein 12 overexpression during hypoxia downregulated VEGF secretion, and this conditioned medium reduced VEGF and Glut-1 expression in HRMECs, suggesting that communications between astrocytes and endothelial cells may be the determinants of the blood vessel network...
October 11, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29021433/a-case-of-secondary-syphilis-with-pulmonary-involvement
#11
Azusa Ohta, Norihiro Furusyo, Yasuhiro Kishihara, Kunimitsu Eiraku, Masayuki Murata, Mosaburo Kainuma, Kazuhiro Toyoda, Eiichi Ogawa, Takeo Hayashi, Tsunehisa Koga
A 39-year-old Japanese man presented to our hospital complaining of left chest pain and rash on the hands and feet. Plain thoracic computed tomography (CT) revealed multiple nodular shadows in the left lower lobe of the lung. A diagnosis of secondary syphilis was made based on the appearance of the rash and positive serologic tests for syphilis. The patient was started on amoxicillin but was switched to minocycline due to amoxicillin-induced rash on both forearms. Thoracic CT after five months of treatment revealed that the multiple lung nodular shadows had contracted, and secondary syphilis with pulmonary involvement was diagnosed...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29020959/configurable-wearable-sensing-and-vibrotactile-feedback-system-for-real-time-postural-balance-and-gait-training-proof-of-concept
#12
Junkai Xu, Tian Bao, Ung Hee Lee, Catherine Kinnaird, Wendy Carender, Yangjian Huang, Kathleen H Sienko, Peter B Shull
BACKGROUND: Postural balance and gait training is important for treating persons with functional impairments, however current systems are generally not portable and are unable to train different types of movements. METHODS: This paper describes a proof-of-concept design of a configurable, wearable sensing and feedback system for real-time postural balance and gait training targeted for home-based treatments and other portable usage. Sensing and vibrotactile feedback are performed via eight distributed, wireless nodes or "Dots" (size: 22...
October 11, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29019760/mr-lymphangiography-in-children-technique-and-potential-applications
#13
Govind B Chavhan, Joao G Amaral, Michael Temple, Maxim Itkin
The lymphatic system, an important component of the circulatory system with essential physiologic functions, can be affected by various disease processes. There has been a delay in the development of effective imaging methods for the lymphatic system due to its small size, which limits visualization as well as introduction of contrast material. Traditionally, the lymphatic system has been imaged by injecting contrast material or radiotracers into the feet or hands. This is not sufficient for assessment of the central conducting lymphatics (CCLs) (such as the thoracic duct or the cisterna chyli)...
October 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29019756/imaging-of-skeletal-disorders-caused-by-fibroblast-growth-factor-receptor-gene-mutations
#14
Kiran M Sargar, Achint K Singh, Simon C Kao
Fibroblast growth factors and fibroblast growth factor receptors (FGFRs) play important roles in human axial and craniofacial skeletal development. FGFR1, FGFR2, and FGFR3 are crucial for both chondrogenesis and osteogenesis. Mutations in the genes encoding FGFRs, types 1-3, are responsible for various skeletal dysplasias and craniosynostosis syndromes. Many of these disorders are relatively common in the pediatric population, and diagnosis is often challenging. These skeletal disorders can be classified based on which FGFR is affected...
October 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29018005/the-clinical-presentation-of-subcutaneous-phaeohyphomycosis-a-case-series-from-yetebon-ethiopia
#15
Rachel B Kang, Devin C Simonson, Sarah E Stoner, William A Agger
Subcutaneous phaeohyphomycosis is a chronic fungal infection usually found on the lower extremity and feet of agricultural workers in the tropics. It can present with various skin manifestations, verrucous to nodular plaques, and is caused by multiple species of fungi. Laboratory confirmation requires skin samples for pathology and fungal cultures. Cure, often difficult in resource-poor countries, requires months of antifungal therapy. We describe the cases of 3 men from Ethiopia who were seen and are being treated by American doctors who traveled there on a medical mission...
October 10, 2017: Clinical Medicine & Research
https://www.readbyqxmd.com/read/29017000/visual-and-postural-motion-evoked-dizziness-symptoms-are-predominant-in-vestibular-migraine-patients
#16
Doga Vuralli, Funuzar Yildirim, Didem T Akcali, Mustafa N Ilhan, Nebil Goksu, Hayrunnisa Bolay
Background: Vestibular migraine (VM) is one of the most common underdiagnosed disorders. We aimed to study the clinical characteristics of VM patients who were referred to a neurology-headache unit by otolaryngology after exclusion of peripheral causes of vertigo. Methods: One hundred and one patients diagnosed with VM in the headache unit were included. Description of vestibular symptoms, demographic and clinical features, trigger factors, accompanying diseases, and response to vestibular-suppressant medications and prophylactic migraine treatment were evaluated...
July 13, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29016991/case-report-of-asthma-associated-with-3d-printing
#17
R House, N Rajaram, S M Tarlo
Background: Three-dimensional (3D) printing is being increasingly used in manufacturing and by small business entrepreneurs and home hobbyists. Exposure to airborne emissions during 3D printing raises the issue of whether there may be adverse health effects associated with these emissions. Aims: We present a case of a worker who developed asthma while using 3D printers, which illustrates that respiratory problems may be associated with 3D printer emissions. Case report: The patient was a 28-year-old self-employed businessman with a past history of asthma in childhood, which had resolved completely by the age of eight...
August 23, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28993756/trench-foot-or-non-freezing-cold-injury-as-a-painful-vaso-neuropathy-clinical-and-skin-biopsy-assessments
#18
Praveen Anand, Rosario Privitera, Yiangos Yiangou, Philippe Donatien, Rolfe Birch, Peter Misra
BACKGROUND: Trench foot, or non-freezing cold injury (NFCI), results from cold exposure of sufficient severity and duration above freezing point, with consequent sensory and vascular abnormalities which may persist for years. Based on observations of Trench foot in World War II, the condition was described as a vaso-neuropathy. While some reports have documented nerve damage after extreme cold exposure, sensory nerve fibres and vasculature have not been assessed with recent techniques in NFCI...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28993571/job-safety-analysis-and-hazard-identification-for-work-accident-prevention-in-para-rubber-wood-sawmills-in-southern-thailand
#19
Phayong Thepaksorn, Supawan Thongjerm, Salee Incharoen, Wattasit Siriwong, Kouji Harada, Akio Koizumi
OBJECTIVE: We utilized job safety analysis (JSA) and hazard identification for work accident prevention in Para rubber wood sawmills, which aimed to investigate occupational health risk exposures and assess the health hazards at sawmills in the Trang Province, located in southern Thailand. METHODS: We conducted a cross-sectional study which included a walk-through survey, JSA, occupational risk assessment, and environmental samplings from March through September 2015 at four Para rubber wood sawmills...
October 7, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/28992911/whole-body-vibration-exercise-on-hematology-and-serum-biochemistry-in-healthy-dogs
#20
Ivan Felismino Charas Santos, Sheila Canevese Rahal, Jussara Shimono, Miriam Tsunemi, Regina Takahira, Carlos Roberto Teixeira
The present study aimed to evaluate the influence of whole-body vibration (WBV) exercise on hematology and serum biochemistry in healthy dogs. Ten intact beagle dogs, 3 females, and 7 males, with a mean age of 3 years, and mean body mass of 14.3kg, body condition score between 4.0/9 and 4.5/9 were evaluated. The WBV sessions were done with the dog standing up on all 4 feet on a vibrating platform. Daily session of 30Hz for 5 minutes, followed by 50Hz for 5 minutes and finishing with 30Hz for 5 minutes was accomplished for 5 days...
June 2017: Topics in Companion Animal Medicine
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