Mengqi Su, Wenpeng Li, Yue Yuan, Siyao Liu, Chen Liang, H E Liu, Ruixin Zhang, Yang Liu, L I Sun, Ying Wei, Chunlei Li, Xuejie Han, Hongting Hao, Xinbo Zhao, Yingchun Luo, Sen Yan, Zhenwei Pan, Yue Li
Cardiac fibrosis is a process characterized by extracellular matrix accumulation leading to myocardial dysfunction. Angiotensin II (Ang II) has been shown to play an important role in the pathogenesis of cardiac fibrosis. However, the underlying mechanisms are not well established. Dysfunction of adipose tissue has been shown to promote remote organ injury, but its role in Ang II-induced cardiac remodeling is still unclear. In this study, we demonstrated that epididymal white adipose tissue (eWAT) promoted Ang II-induced cardiac fibrosis and subsequent cardiac dysfunction in an exosome-dependent manner...
October 2022: Translational Research: the Journal of Laboratory and Clinical Medicine