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Bronchodilators in bronchiolitis

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https://www.readbyqxmd.com/read/27892438/comparison-of-initial-response-of-nebulized-salbutamol-and-adrenaline-in-infants-and-young-children-admitted-with-acute-bronchiolitis
#1
S Adhikari, P Thapa, K S Rao, G Bk
Background Acute bronchiolitis is common cause of hospitalization in infants and young children. There are widespread variations in the diagnosis and management. Despite the use of bronchodilators for decades, there is lack of consensus for the benefit of one above another. Objective To compare initial response of nebulized adrenaline and salbutamol. Method Children aged two months to two years admitted with acute bronchiolitis in the department of Paediatrics of Manipal teaching hospital, Pokhara, Nepal, from 1st March 2014 to 28th February 2015 were enrolled...
January 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/27885562/respiratory-syncytial-virus-and-influenza-are-the-key-viral-pathogens-in-children-2%C3%A2-years-hospitalized-with-bronchiolitis-and-pneumonia-in-islamabad-pakistan
#2
Uzma Bashir, Nadia Nisar, Yasir Arshad, Muhammad Masroor Alam, Asiya Ashraf, Hajra Sadia, Birjees Mazher Kazi, Syed Sohail Zahoor Zaidi
Pneumonia remains a leading cause of morbidity and mortality in developing countries. Comprehensive surveillance data are needed to review the prevention and control strategies. We conducted active surveillance of acute lower respiratory infections among children aged <2 years hospitalized at two hospitals of Islamabad, Pakistan. Viral etiology was determined using real-time PCR on respiratory specimens collected during March 2011-April 2012. The overall mean age was 7.83 ± 5.25 months while no statistical difference between age or sex distribution of patients with positive and negative viral etiology (p > 0...
November 24, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27743492/respiratory-reactance-in-children-aged-3-5-years-with-post-infectious-bronchiolitis-obliterans-is-higher-than-in-those-with-asthma
#3
Eun Lee, Jisun Yoon, Soo-Jong Hong, Jinho Yu
AIM: We investigated airway function in preschoolers with post-infectious bronchiolitis obliterans (PIBO) using impulse oscillometry (IOS). METHODS: This study enrolled 182 children aged 3-5 years: 12 with PIBO, 135 asthma with asthma and 35 non-atopic controls. Respiratory resistance and reactance were assessed using IOS. RESULTS: The percentage predicted (% predicted) of pre-bronchodilator respiratory resistance at 5Hz was significantly higher in children with PIBO (177...
October 15, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27650524/bronchiolitis-in-young-infants-is-it-a-risk-factor-for-recurrent-wheezing-in-childhood
#4
Firas Rinawi, Imad Kassis, Rina Tamir, Amir Kugelman, Isaac Srugo, Dan Miron
BACKGROUND: Acute bronchiolitis in infancy is considered a risk factor for recurrent wheezing episodes in childhood. The present study assessed prevalence, clinical manifestations and risk factors for recurrent wheezing events during the first 3 years of life and persistent wheezing events beyond this age in children hospitalized as young infants with acute bronchiolitis. METHODS: Two groups of children aged 6 years were included. The study group comprised 150 children with a history of hospitalization for bronchiolitis, with the first event at <6 months of age...
September 20, 2016: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/27603231/role-of-endogenous-hydrogen-sulfide-in-nerve-evoked-relaxation-of-pig-terminal-bronchioles
#5
Vítor S Fernandes, Paz Recio, Elvira López-Oliva, María Pilar Martínez, Ana Sofía Ribeiro, María Victoria Barahona, Ana Cristina Martínez, Sara Benedito, Ángel Agis-Torres, Alberto Cabañero, Gemma M Muñoz, Albino García-Sacristán, Luis M Orensanz, Medardo Hernández
Hydrogen sulfide (H2S) is a gasotransmitter employed for intra- and inter-cellular communication in almost all organ systems. This study investigates the role of endogenous H2S in nerve-evoked relaxation of pig terminal bronchioles with 260 μm medium internal lumen diameter. High expression of the H2S synthesis enzyme cystathionine γ-lyase (CSE) in the bronchiolar muscle layer and strong CSE-immunoreactivity within nerve fibers distributed along smooth muscle bundles were observed. Further, endogenous H2S generated in bronchiolar membranes was reduced by CSE inhibition...
September 4, 2016: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27549684/viral-bronchiolitis
#6
Todd A Florin, Amy C Plint, Joseph J Zorc
Viral bronchiolitis is a common clinical syndrome affecting infants and young children. Concern about its associated morbidity and cost has led to a large body of research that has been summarised in systematic reviews and integrated into clinical practice guidelines in several countries. The evidence and guideline recommendations consistently support a clinical diagnosis with the limited role for diagnostic testing for children presenting with the typical clinical syndrome of viral upper respiratory infection progressing to the lower respiratory tract...
August 20, 2016: Lancet
https://www.readbyqxmd.com/read/27472490/following-up-infant-bronchiolitis-patients-provided-new-evidence-for-and-against-the-united-airway-disease-hypothesis
#7
Eero Lauhkonen, Petri Koponen, Kirsi Nuolivirta, Merja Helminen, Marita Paassilta, Jyri Toikka, Matti Korppi
AIM: The united airway disease (UAD) hypothesis suggests that allergic rhinitis and asthma develop together. We evaluated the evidence for and against the UAD hypothesis at five to seven years of age after hospitalisation for bronchiolitis at less than six months. METHODS: This study used prospective follow-up data for 102 children hospitalised for bronchiolitis under the age of six months. We included the presence of previous and current asthma, prolonged rhinitis and skin prick tests (SPT) to common inhaled allergens and lung function by impulse oscillometry (IOS) at five to seven years of age...
November 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27402352/what-works-to-reduce-unnecessary-care-in-bronchiolitis-a-qualitative-analysis-of-a-national-collaborative
#8
Shawn L Ralston, Emily Carson Atwood, Matthew D Garber, Alison Volpe Holmes
OBJECTIVES: Unnecessary care is well-established as a quality problem affecting acute viral bronchiolitis, one of the most common pediatric illnesses. While there is an extensive quality improvement literature on the disease, published work primarily reflects the experience of freestanding children's hospitals. We sought to better understand the specific barriers and drivers for successful quality improvement in community and non-freestanding children's facilities. METHODS: We undertook a mixed methods study to identify correlates of success in a bronchiolitis quality improvement collaborative of community hospitals and children's hospitals within adult hospitals...
July 8, 2016: Academic Pediatrics
https://www.readbyqxmd.com/read/27383939/impact-of-long-term-treatment-with-inhaled-corticosteroids-and-bronchodilators-on-lung-function-in-a-patient-with-post-infectious-bronchiolitis-obliterans
#9
Cecilia Calabrese, Nadia Corcione, Gaetano Rea, Francesco Stefanelli, Ilernando Meoli, Alessandro Vatrella
Post-infectious bronchiolitis obliterans (PIBO) is a small airways disease characterized by fixed airflow limitation. Therefore, inhaled bronchodilators and corticosteroids are not recommended as maintenance therapy options. The management of PIBO currently consists only of close monitoring of affected patients, aimed at the prevention and early treatment of pulmonary infections. In recent years, there has been an increase in the incidence of PIBO in the pediatric population. Patients with PIBO are characterized by a progressive decline in lung function, accompanied by a decrease in overall functional capacity...
May 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/27383929/evaluating-bronchodilator-response-in-pediatric-patients-with-post-infectious-bronchiolitis-obliterans-use-of-different-criteria-for-identifying-airway-reversibility
#10
Rita Mattiello, Paula Cristina Vidal, Edgar Enrique Sarria, Paulo Márcio Pitrez, Renato Tetelbom Stein, Helena Teresinha Mocelin, Gilberto Bueno Fischer, Marcus Herbert Jones, Leonardo Araújo Pinto
OBJECTIVE: Post-infectious bronchiolitis obliterans (PIBO) is a clinical entity that has been classified as constrictive, fixed obstruction of the lumen by fibrotic tissue. However, recent studies using impulse oscillometry have reported bronchodilator responses in PIBO patients. The objective of this study was to evaluate bronchodilator responses in pediatric PIBO patients, comparing different criteria to define the response. METHODS: We evaluated pediatric patients diagnosed with PIBO and treated at one of two pediatric pulmonology outpatient clinics in the city of Porto Alegre, Brazil...
May 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/27303780/acute-viral-bronchiolitis-in-south-africa-strategies-for-management-and-prevention
#11
H J Zar, S A Madhi, D A White, R Masekela, S Risenga, H Lewis, C Feldman, B Morrow, P Jeena
Management of acute viral bronchiolitis is largely supportive. There is currently no proven effective therapy other than oxygen for hypoxic children. The evidence indicates that there is no routine benefit from inhaled, rapid short-acting bronchodilators, adrenaline or ipratropium bromide for children with acute viral bronchiolitis. Likewise, there is no demonstrated benefit from routine use of inhaled or oral corticosteroids, inhaled hypertonic saline nebulisation, montelukast or antibiotics. The last should be reserved for children with severe disease, when bacterial co-infection is suspected...
April 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27226660/do-we-really-ponder-about-necessity-of-intravenous-hydration-in-acute-bronchiolitis
#12
Şule Yıldırım, Nazan Kaymaz, Naci Topaloğlu, Fatih Köksal Binnetoğlu, Mustafa Tekin, Hakan Aylanç, Fatih Battal, Burçin Gön Uuml Ll Uuml
OBJECTIVE: The goal was to establish the role of intravenous hydration therapy on mild bronchiolitis. METHODS: This was a retrospective case control study. Infants between 1 month and 2 years of age admitted to our general pediatrics ward between June 2012 and June 2013 with a diagnosis of uncomplicated acute bronchiolitis were enrolled to the study. Hospital medical files were reviewed to get information about children personal history, symptoms of the disease, disease severity scores and their management...
2016: Colombia Médica: CM
https://www.readbyqxmd.com/read/27141475/effectiveness-of-3-hypertonic-saline-nebulization-in-acute-bronchiolitis-among-indian-children-a-quasi-experimental-study
#13
Harsh V Gupta, Vivek V Gupta, Gurmeet Kaur, Amitoz S Baidwan, Pardeep P George, Jay C Shah, Kushal Shinde, Ruku Malik, Neha Chitkara, Krushnan V Bajaj
OBJECTIVE: To compare the effects of 3% hypertonic saline (HS) and 0.9% normal saline with nebulized 0.9% normal saline with salbutamol in patients of acute viral bronchiolitis. MATERIALS AND METHODS: Participants were divided into three groups, that is, 3% HS group, 0.9% normal saline group and 0.9% saline with salbutamol group. Four doses at interval of 6 h were given daily until discharge. Average CS score and length of hospital stay were compared. One-way analysis of variance paired t-test and Chi-square test were utilized for statistical analysis...
April 2016: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/26942260/bronchiolitis-in-infants-do-not-use-bronchodilators
#14
(no author information available yet)
A Cochrane systematic review of studies including nearly 2000 infants showed that bronchodilators have no proven efficacy in bronchiolitis.
January 2016: Prescrire International
https://www.readbyqxmd.com/read/26906352/management-of-bronchiolitis-in-community-hospitals-in-ontario-a-multicentre-cohort-study
#15
Amy C Plint, Monica Taljaard, Candice McGahern, Shannon D Scott, Jeremy M Grimshaw, Terry P Klassen, David W Johnson
OBJECTIVES: Bronchiolitis is the leading cause of hospital admission for infants, but few studies have examined management of this condition in community hospital settings. We reviewed the management of children with bronchiolitis presenting to community hospitals in Ontario. METHODS: We retrospectively reviewed a consecutive cohort of infants less than 12 months old with bronchiolitis who presented to 28 Ontario community hospitals over a two-year period. Bronchiolitis was defined as first episode of wheezing associated with signs of an upper respiratory tract infection during respiratory syncytial virus season...
February 24, 2016: CJEM
https://www.readbyqxmd.com/read/26833493/chest-physiotherapy-for-acute-bronchiolitis-in-paediatric-patients-between-0-and-24-months-old
#16
REVIEW
Marta Roqué i Figuls, Maria Giné-Garriga, Claudia Granados Rugeles, Carla Perrotta, Jordi Vilaró
BACKGROUND: This Cochrane review was first published in 2005 and updated in 2007, 2012 and now 2015. Acute bronchiolitis is the leading cause of medical emergencies during winter in children younger than two years of age. Chest physiotherapy is sometimes used to assist infants in the clearance of secretions in order to decrease ventilatory effort. OBJECTIVES: To determine the efficacy of chest physiotherapy in infants aged less than 24 months old with acute bronchiolitis...
February 1, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26770220/postinfectious-bronchiolitis-obliterans-in-children-lessons-from-bronchiolitis-obliterans-after-lung-transplantation-and-hematopoietic-stem-cell-transplantation
#17
REVIEW
Jinho Yu
Postinfectious bronchiolitis obliterans (PIBO) is an irreversible obstructive lung disease characterized by subepithelial inflammation and fibrotic narrowing of the bronchioles after lower respiratory tract infection during childhood, especially early childhood. Although diagnosis of PIBO should be confirmed by histopathology, it is generally based on history and clinical findings. Irreversible airway obstruction is demonstrated by decreased forced expiratory volume in 1 second with an absent bronchodilator response, and by mosaic perfusion, air trapping, and/or bronchiectasis on computed tomography images...
December 2015: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/26662887/relaxing-effect-of-a-new-ruthenium-complex-nitric-oxide-donor-on-airway-smooth-muscle-of-an-experimental-model-of-asthma-in-rats
#18
Patrícia Ferreira da Silva Castro, Daniela Lobo de Andrade, Carolina de Fátima Reis, Sérgio Henrique Nascente Costa, Aline Carvalho Batista, Roberto Santana da Silva, Matheus Lavorenti Rocha
NO is a potent bronchodilator and NO-donor compounds have demonstrated clinical significance for obstructive airway diseases. This study evaluated the relaxation mechanisms of two NO donors, a ruthenium compound (TERPY), and sodium nitroprusside (SNP), in rat tracheas with ovalbumin-induced asthma (OVA group) and in another control group. The effect of TERPY and SNP was evaluated in tracheal rings in an isolated organ chamber. The contribution of K(+) channels, sGC/cGMP pathway, phosphodiesterases, and extra and intracellular Ca(2+) sources were analyzed...
February 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/26628731/a-multicenter-collaborative-to-reduce-unnecessary-care-in-inpatient-bronchiolitis
#19
MULTICENTER STUDY
Shawn L Ralston, Matthew D Garber, Elizabeth Rice-Conboy, Grant M Mussman, Kristin A Shadman, Susan C Walley, Elizabeth Nichols
BACKGROUND AND OBJECTIVE: Evidence-based Guidelines for acute viral bronchiolitis recommend primarily supportive care, but unnecessary care remains well documented. Published quality improvement work has been accomplished in children's hospitals, but little broad dissemination has been reported outside of those settings. We sought to use a voluntary collaborative strategy to disseminate best practices to reduce overuse of unnecessary care in children hospitalized for bronchiolitis in community settings...
January 2016: Pediatrics
https://www.readbyqxmd.com/read/26596964/the-effect-of-implementation-of-standardized-evidence-based-order-sets-on-efficiency-and-quality-measures-for-pediatric-respiratory-illnesses-in-a-community-hospital
#20
Anuradha Dayal, Francisco Alvarez
OBJECTIVE: Standardization of evidence-based care, resource utilization, and cost efficiency are commonly used metrics to measure inpatient clinical care delivery. The aim of our project was to evaluate the effect of pediatric respiratory order sets and an asthma pathway on the efficiency and quality measures of pediatric patients treated with respiratory illnesses in an adult community hospital setting. METHODS: We used a pre-post study to review pediatric patients admitted to the inpatient setting with the primary diagnoses of asthma, bronchiolitis, or pneumonia...
December 2015: Hospital Pediatrics
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