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https://www.readbyqxmd.com/read/29054477/-update-on-recommendations-for-screening-for-hydroxychloroquine-retinopathy
#1
A Couturier, A Giocanti-Aurégan, B Dupas, J-F Girmens, Y Le Mer, N Massamba, E Barreau, I Audo
INTRODUCTION: Recommendations for screening for chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy have recently been changed by the American Academy of Ophthalmology, taking into account new published data on toxicity prevalence, risk factors, location of onset in the retina and the efficacy of screening tests. METHODS: Literature review. RESULTS AND DISCUSSION: The risk of developing CQ or HCQ retinopathy depends on the daily dose and duration of treatment...
October 17, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29052924/mers-sars-and-other-coronaviruses-as-causes-of-pneumonia
#2
REVIEW
Yudong Yin, Richard G Wunderink
Human coronaviruses (HCoVs) have been considered to be relatively harmless respiratory pathogens in the past. However, after the outbreak of the severe acute respiratory syndrome (SARS) and emergence of the Middle East respiratory syndrome (MERS), HCoVs have received worldwide attention as important pathogens in respiratory tract infection. This review focuses on the epidemiology, pathogenesis and clinical characteristics among SARS-coronaviruses (CoV), MERS-CoV and other HCoV infections.
October 20, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29050198/mtorc1-autophagy-regulated-mertk-in-mutant-brafv600-melanoma-with-acquired-resistance-to-braf-inhibition
#3
Gongda Xue, Reto Kohler, Fengyuan Tang, Debby Hynx, Yuhua Wang, Francesca Orso, Vincent Prêtre, Reto Ritschard, Petra Hirschmann, Peter Cron, Tim Roloff, Reinhard Dummer, Mario Mandalà, Sandrine Bichet, Christel Genoud, Alexandra G Meyer, Manuele G Muraro, Giulio C Spagnoli, Daniela Taverna, Curzio Rüegg, Taha Merghoub, Daniela Massi, Huifang Tang, Mitchell P Levesque, Stephan Dirnhofer, Alfred Zippelius, Brian A Hemmings, Andreas Wicki
BRAF inhibitors (BRAFi) and the combination therapy of BRAF and MEK inhibitors (MEKi) were recently approved for therapy of metastatic melanomas harbouring the oncogenic BRAFV600 mutation. Although these therapies have shown pronounced therapeutic efficacy, the limited durability of the response indicates an acquired drug resistance that still remains mechanistically poorly understood at the molecular level. We conducted transcriptome gene profiling in BRAFi-treated melanoma cells and identified that Mer tyrosine kinase (MerTK) is specifically upregulated...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049777/annals-consult-guys-mythbuster-preoperative-blood-pressure-control
#4
Geno J Merli, Howard H Weitz
No abstract text is available yet for this article.
October 17, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29048984/development-of-middle-east-respiratory-syndrome-coronavirus-vaccines-advances-and-challenges
#5
Heeyoun Cho, Jean-Louis Excler, Jerome H Kim, In-Kyu Yoon
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an emerging pathogen with the potential to pose a threat to global public health. Sporadic cases and outbreaks continue to be reported in the Middle East, and case fatality rates remain high at approximately 36% globally. No specific preventive or therapeutic countermeasures currently exist. A safe and effective vaccine could play an important role in protecting against the threat from MERS-CoV. This review discusses human vaccine candidates currently under development, and explores viral characteristics, molecular epidemiology and immunology relevant to MERS-CoV vaccine development...
October 19, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29048594/neptune-a-bioinformatics-tool-for-rapid-discovery-of-genomic-variation-in-bacterial-populations
#6
Eric Marinier, Rahat Zaheer, Chrystal Berry, Kelly A Weedmark, Michael Domaratzki, Philip Mabon, Natalie C Knox, Aleisha R Reimer, Morag R Graham, Linda Chui, Laura Patterson-Fortin, Jian Zhang, Franco Pagotto, Jeff Farber, Jim Mahony, Karine Seyer, Sadjia Bekal, Cécile Tremblay, Judy Isaac-Renton, Natalie Prystajecky, Jessica Chen, Peter Slade, Gary Van Domselaar
The ready availability of vast amounts of genomic sequence data has created the need to rethink comparative genomics algorithms using 'big data' approaches. Neptune is an efficient system for rapidly locating differentially abundant genomic content in bacterial populations using an exact k-mer matching strategy, while accommodating k-mer mismatches. Neptune's loci discovery process identifies sequences that are sufficiently common to a group of target sequences and sufficiently absent from non-targets using probabilistic models...
October 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29046060/a-crystalline-monomeric-allenyl-propargyl-radical
#7
Max M Hansmann, Mohand Melaimi, Guy Bertrand
Reduction of alkynyl iminium salts derived from cyclic (alkyl)(amino)carbenes (CAACs) affords propargyl/allenyl radicals. Depending on the nature of the CAAC and alkyne sub-stituents, these radicals can irreversibly dimerize, exist as mono-mers in solution but dimerize in the solid state, or can even remain monomeric as solids. The first characterization of an allenyl radi-cal by single crystal X-ray crystallography is reported.
October 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29045613/genome-structure-of-rosa-multiflora-a-wild-ancestor-of-cultivated-roses
#8
Noriko Nakamura, Hideki Hirakawa, Shusei Sato, Shungo Otagaki, Shogo Matsumoto, Satoshi Tabata, Yoshikazu Tanaka
The draft genome sequence of a wild rose (Rosa multiflora Thunb.) was determined using Illumina MiSeq and HiSeq platforms. The total length of the scaffolds was 739,637,845 bp, consisting of 83,189 scaffolds, which was close to the 711 Mbp length estimated by k-mer analysis. N50 length of the scaffolds was 90,830 bp, and extent of the longest was 1,133,259 bp. The average GC content of the scaffolds was 38.9%. After gene prediction, 67,380 candidates exhibiting sequence homology to known genes and domains were extracted, which included complete and partial gene structures...
October 16, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/29044371/nosocomial-amplification-of-mers-coronavirus-in-south-korea-2015
#9
Maimuna S Majumder, John S Brownstein, Stan N Finkelstein, Richard C Larson, Lydia Bourouiba
Background: Nosocomial amplification resulted in nearly 200 cases of Middle East respiratory syndrome (MERS) during the 2015 South Korean MERS-coronavirus outbreak. It remains unclear whether certain types of cases were more likely to cause secondary infections than others, and if so, why. Methods: Publicly available demographic and transmission network data for all cases were collected from the Ministry of Health and Welfare. Statistical analyses were conducted to determine the relationship between demographic characteristics and the likelihood of human-to-human transmission...
June 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29043032/tracing-coco-de-mer-s-reproductive-history-pollen-and-nutrient-limitations-reduce-fecundity
#10
Emma J Morgan, Christopher N Kaiser-Bunbury, Peter J Edwards, Frauke Fleischer-Dogley, Chris J Kettle
Habitat degradation can reduce or even prevent the reproduction of previously abundant plant species. To develop appropriate management strategies, we need to understand the reasons for reduced recruitment in degraded ecosystems. The dioecious coco de mer palm (Lodoicea maldivica) produces by far the largest seeds of any plant. It is a keystone species in an ancient palm forest that occurs only on two small islands in the Seychelles, yet contemporary rates of seed production are low, especially in fragmented populations...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29038808/decoration-of-trastuzumab-with-short-oligonucleotides-synthesis-and-detailed-characterization
#11
A M Carvalho, A Manicardi, C Véliz Montes, S B Gunnoo, R J Schneider, A Madder
Trastuzumab (Herceptin®) is an FDA-approved therapeutic antibody currently employed in the treatment of metastatic stages of breast cancer. Herein, we propose a simple, fast and cost-effective methodology to conjugate trastuzumab with 22-mer 5' thiol-modified oligonucleotides using a bifunctional crosslinker. The conjugates were successfully characterized by MALDI-ToF MS and SDS-PAGE, obviating the need for enzymatic digestion and difficult chromatographic separations. Furthermore, ELISA was performed to ensure that trastuzumab activity is not affected by oligonucleotide conjugation...
October 17, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29037978/expected-immunizations-and-health-protection-for-hajj-and-umrah-2018-an-overview
#12
REVIEW
Jaffar A Al-Tawfiq, Philippe Gautret, Ziad A Memish
BACKGROUND: The annual Hajj and Umrah are one of the largest recurring religious mass gatherings across the globe drawing pilgrims from more than 185 countries. The living circumstances and activities of the pilgrims may create an environment for the occurrence and spread of communicable diseases. Each year, the Health authority of the Kingdom of Saudi Arabia, in coordination with international health authorities, updates health requirements for pilgrims. The Hajj for 2017 took place from August 24 to September 5, 2017...
October 13, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29036597/faucet-streaming-de-novo-assembly-graph-construction
#13
Roye Rozov, Gil Goldshlager, Eran Halperin, Ron Shamir
Motivation: We present Faucet, a two-pass streaming algorithm for assembly graph construction. Faucet builds an assembly graph incrementally as each read is processed. Thus, reads need not be stored locally, as they can be processed while downloading data and then discarded. We demonstrate this functionality by performing streaming graph assembly of publicly available data, and observe that the ratio of disk use to raw data size decreases as coverage is increased. Results: Faucet pairs the de Bruijn graph obtained from the reads with additional meta-data derived from them...
July 24, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036588/a-novel-data-structure-to-support-ultra-fast-taxonomic-classification-of-metagenomic-sequences-with-k-mer-signatures
#14
Xinan Liu, Ye Yu, Jinpeng Liu, Corrine F Elliott, Chen Qian, Jinze Liu
Motivation: Metagenomic read classification is a critical step in the identification and quantification of microbial species sampled by high-throughput sequencing. Although many algorithms have been developed to date, they suffer significant memory and/or computational costs. Due to the growing popularity of metagenomic data in both basic science and clinical applications, as well as the increasing volume of data being generated, efficient and accurate algorithms are in high demand. Results: We introduce MetaOthello, a probabilistic hashing classifier for metagenomic sequencing reads...
July 7, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29035289/molecular-evolution-of-mers-coronavirus-dromedaries-as-a-recent-intermediate-host-or-long-time-animal-reservoir
#15
Susanna K P Lau, Antonio C P Wong, Terrence C K Lau, Patrick C Y Woo
While dromedary camels are the immediate animal source of MERS coronavirus (MERS-CoV) infection, the evolutionary origin of MERS-CoV remains obscure. We analyzed 219 camel and human MERS-CoV genome sequences available in GenBank. Phylogenetic analysis showed that 5 and 214 strains belong to clade A and B, respectively, with clade A further divided into lineage A1 (3 human strains) and lineage A2 (2 camel strains), and clade B divided into B1 to B6 (each containing both human and camel strains). Recombination analysis showed potential recombination events in five strains from dromedaries in Saudi Arabia, with recombination between lineage B5 and B3 in four strains, and between lineage B3 and B4 in one strain...
October 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29034998/the-albumin-bilirubin-grade-uncovers-the-prognostic-relationship-between-hepatic-reserve-and-immune-dysfunction-in-hiv-associated-hepatocellular-carcinoma
#16
D J Pinato, R Sharma, C Citti, H Platt, M Ventura-Cots, E Allara, T-Y Chen, A Dalla Pria, M Jain, B Mínguez, L Kikuchi, E Kaufman West, M Merli, D E Kaplan, H Hasson, K Marks, M Nelson, M Núñez, A Aytaman, M Bower, N Bräu
BACKGROUND: Hepatocellular carcinoma (HCC) is a leading cause of liver-related mortality in people living with HIV, where co-infection with hepatotropic viruses accelerates the course of chronic liver disease. AIM: To evaluate whether the albumin-bilirubin (ALBI) grade, a more accurate marker of liver dysfunction in HCC, might identify patients with progressive liver dysfunction in the context of HIV/hepatitis co-infection. METHODS: Using uni- and multi-variable analyses, we studied the albumin-bilirubin grade as a predictor of overall survival (OS) in a large, multi-center cohort of patients with HIV-associated HCC recruited from 44 centres in 9 countries within the Liver Cancer in HIV study group...
October 16, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29031867/influenza-is-more-common-than-middle-east-respiratory-syndrome-coronavirus-mers-cov-among-hospitalized-adult-saudi-patients
#17
Jaffar A Al-Tawfiq, Ali A Rabaan, Kareem Hinedi
BACKGROUND: Since the initial description of Middle East Respiratory Syndrome Coronavirus (MERS-CoV), we adopted a systematic process of screening admitted patients with community acquired pneumonia. Here, we report the result of the surveillance activity in a general hospital in Saudi Arabia over a four year period. MATERIALS AND METHODS: All admitted patients with community acquired pneumonia from 2012 to 2016 were tested for MERS-CoV. In addition, testing for influenza viruses was carried out starting April 2015...
October 12, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29031546/influenza-virus-but-not-mers-coronavirus-circulation-in-iran-2013-2016-comparison-between-pilgrims-and-general-population
#18
Jila Yavarian, Nazanin Zahra Shafiei Jandaghi, Maryam Naseri, Peyman Hemmati, Mohhamadnasr Dadras, Mohammad Mehdi Gouya, Talat Mokhtari Azad
BACKGROUND: The pilgrimage to Mecca and Karbala bring many Muslims to a confined area. Respiratory tract infections are the most common diseases transmitted during mass gatherings in Hajj, Umrah and Karbala. The aim of this study was to determine and compare the prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) and influenza virus infections among Iranian general population and pilgrims with severe acute respiratory infections (SARI) returning from Mecca and Karbala during 2013-2016...
October 11, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29031518/investigation-of-nonlinear-epidemiological-models-for-analyzing-and-controlling-the-mers-outbreak-in-korea
#19
Inkyung Ahn, Seongman Heo, Seunghyun Ji, Kyung Hyun Kim, Taehwan Kim, Eun Joo Lee, Jooyoung Park, Keehoon Sung
Much concern has arisen regarding serious epidemics due to the Middle East Respiratory Syndrome (MERS) coronavirus. The first MERS case of Korea was reported on 20 May 2015, and since then, the MERS outbreak in Korea has resulted in hundreds of confirmed cases and tens of deaths. Deadly infectious diseases such as MERS have significant direct and indirect social impacts, which include disease-induced mortality and economic losses. Also, a delayed response to the outbreak and underestimating its danger can further aggravate the situation...
October 12, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29030179/designing-probe-from-e6-genome-region-of-human-papillomavirus-16-for-sensing-applications
#20
Nor Azizah Parmin, Uda Hashim, Subash C B Gopinath
Human Papillomavirus (HPV) is a standout amongst the most commonly reported over 100 types, among them genotypes 16, 18, 31 and 45 are the high-risk HPV. Herein, we designed the oligonucleotide probe for the detection of predominant HPV type 16 for the sensing applications. Conserved amino acid sequences within E6 region of the open reading frame in the HPV genome was used as the basis to design oligonucleotide probe to detect cervical cancer. Analyses of E6 amino acid sequences from the high-risk HPVs were done to check the percentage of similarity and consensus regions that cause different cancers, including cervical cancer...
October 10, 2017: International Journal of Biological Macromolecules
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