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https://www.readbyqxmd.com/read/29909495/the-neuro-immune-regulators-niregs-promote-tissue-resilience-a-vital-component-of-the-host-s-defense-strategy-against-neuroinflammation
#1
REVIEW
Yosra Bedoui, Jim W Neal, Philippe Gasque
An effective protective inflammatory response in the brain is crucial for the clearance of pathogens (e.g. microbes, amyloid fibrils, prionSC ) and should be closely regulated. However, the CNS seems to have limited tissue resilience to withstand the detrimental effects of uncontrolled inflammation compromising functional recovery and tissue repair. Newly described neuro-immune-regulators (NIREGs) are functionally related proteins regulating the severity and duration of the host inflammatory response. NIREGs such as CD200, CD47 and CX3CL1 are vital for increasing tissue resilience and are constitutively expressed by neurons...
June 16, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29909242/initial-characterization-of-newly-identified-mitochondrial-and-chloroplast-small-hsps-from-sugarcane-shows-that-these-chaperones-have-different-oligomerization-states-and-substrate-specificities
#2
Glaucia M S Pinheiro, Carlos H I Ramos
Chaperones belonging to the small heat shock protein (sHSP) family are ubiquitous and exhibit elevated expression under stresses conditions to protect proteins against aggregation, thereby contributing to the stress tolerance of the organism. Tropical plants are constantly exposed to high temperatures, and the mechanisms by which these plants tolerate heat stress are of foremost importance to basic science as well as applied agrobiotechnology. Therefore, this study aims to characterize sHSPs from different organelles from sugarcane, an important crop that is associated with sugar and bioenergy production...
June 4, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29906767/electrochemical-primer-extension-based-on-polyoxometalate-electroactive-labels-for-multiplexed-detection-of-single-nucleotide-polymorphisms
#3
Nassif Chahin, Laura A Uribe, Ahmed M Debela, Serge Thorimbert, Bernold Hasenknopf, Mayreli Ortiz, Ioannis Katakis, Ciara K O'Sullivan
Polyoxymetalates (POMs) ([SiW11 O39 {Sn(CH2 )2 CO)}]4- and [P2 W17 O61 {Sn(CH2 )2 CO)}]6- ) were used to modify dideoxynucleotides (ddNTPs) through amide bond formation, and applied to the multiplexed detection of single nucleotide polymorphisms (SNPs) in an electrochemical primer extension reaction. Each gold electrode of an array was functionalised with a short single stranded thiolated DNA probe, specifically designed to extend with the POM-ddNTP at the SNP site to be interrogated. The system was applied to the simultaneous detection of 4 SNPs within a single stranded 103-mer model target generated using asymmetric PCR, highlighting the potential of POM-ddNTPs for targeted, multiplexed SNP detection...
June 7, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29906142/evidence-for-the-rare-decay-%C3%AE-%C3%A2-p%C3%AE-%C3%AE
#4
R Aaij, B Adeva, M Adinolfi, Z Ajaltouni, S Akar, J Albrecht, F Alessio, M Alexander, A Alfonso Albero, S Ali, G Alkhazov, P Alvarez Cartelle, A A Alves, S Amato, S Amerio, Y Amhis, L An, L Anderlini, G Andreassi, M Andreotti, J E Andrews, R B Appleby, F Archilli, P d'Argent, J Arnau Romeu, A Artamonov, M Artuso, E Aslanides, M Atzeni, G Auriemma, M Baalouch, I Babuschkin, S Bachmann, J J Back, A Badalov, C Baesso, S Baker, V Balagura, W Baldini, A Baranov, R J Barlow, C Barschel, S Barsuk, W Barter, F Baryshnikov, V Batozskaya, V Battista, A Bay, L Beaucourt, J Beddow, F Bedeschi, I Bediaga, A Beiter, L J Bel, N Beliy, V Bellee, N Belloli, K Belous, I Belyaev, E Ben-Haim, G Bencivenni, S Benson, S Beranek, A Berezhnoy, R Bernet, D Berninghoff, E Bertholet, A Bertolin, C Betancourt, F Betti, M O Bettler, M van Beuzekom, Ia Bezshyiko, S Bifani, P Billoir, A Birnkraut, A Bizzeti, M Bjørn, T Blake, F Blanc, S Blusk, V Bocci, T Boettcher, A Bondar, N Bondar, I Bordyuzhin, S Borghi, M Borisyak, M Borsato, F Bossu, M Boubdir, T J V Bowcock, E Bowen, C Bozzi, S Braun, J Brodzicka, D Brundu, E Buchanan, C Burr, A Bursche, J Buytaert, W Byczynski, S Cadeddu, H Cai, R Calabrese, R Calladine, M Calvi, M Calvo Gomez, A Camboni, P Campana, D H Campora Perez, L Capriotti, A Carbone, G Carboni, R Cardinale, A Cardini, P Carniti, L Carson, K Carvalho Akiba, G Casse, L Cassina, M Cattaneo, G Cavallero, R Cenci, D Chamont, M G Chapman, M Charles, Ph Charpentier, G Chatzikonstantinidis, M Chefdeville, S Chen, S F Cheung, S-G Chitic, V Chobanova, M Chrzaszcz, A Chubykin, P Ciambrone, X Cid Vidal, G Ciezarek, P E L Clarke, M Clemencic, H V Cliff, J Closier, V Coco, J Cogan, E Cogneras, V Cogoni, L Cojocariu, P Collins, T Colombo, A Comerma-Montells, A Contu, G Coombs, S Coquereau, G Corti, M Corvo, C M Costa Sobral, B Couturier, G A Cowan, D C Craik, A Crocombe, M Cruz Torres, R Currie, C D'Ambrosio, F Da Cunha Marinho, C L Da Silva, E Dall'Occo, J Dalseno, A Davis, O De Aguiar Francisco, K De Bruyn, S De Capua, M De Cian, J M De Miranda, L De Paula, M De Serio, P De Simone, C T Dean, D Decamp, L Del Buono, H-P Dembinski, M Demmer, A Dendek, D Derkach, O Deschamps, F Dettori, B Dey, A Di Canto, P Di Nezza, H Dijkstra, F Dordei, M Dorigo, A Dosil Suárez, L Douglas, A Dovbnya, K Dreimanis, L Dufour, G Dujany, P Durante, J M Durham, D Dutta, R Dzhelyadin, M Dziewiecki, A Dziurda, A Dzyuba, S Easo, U Egede, V Egorychev, S Eidelman, S Eisenhardt, U Eitschberger, R Ekelhof, L Eklund, S Ely, S Esen, H M Evans, T Evans, A Falabella, N Farley, S Farry, D Fazzini, L Federici, D Ferguson, G Fernandez, P Fernandez Declara, A Fernandez Prieto, F Ferrari, L Ferreira Lopes, F Ferreira Rodrigues, M Ferro-Luzzi, S Filippov, R A Fini, M Fiorini, M Firlej, C Fitzpatrick, T Fiutowski, F Fleuret, M Fontana, F Fontanelli, R Forty, V Franco Lima, M Frank, C Frei, J Fu, W Funk, E Furfaro, C Färber, E Gabriel, A Gallas Torreira, D Galli, S Gallorini, S Gambetta, M Gandelman, P Gandini, Y Gao, L M Garcia Martin, J García Pardiñas, J Garra Tico, L Garrido, D Gascon, C Gaspar, L Gavardi, G Gazzoni, D Gerick, E Gersabeck, M Gersabeck, T Gershon, Ph Ghez, S Gianì, V Gibson, O G Girard, L Giubega, K Gizdov, V V Gligorov, D Golubkov, A Golutvin, A Gomes, I V Gorelov, C Gotti, E Govorkova, J P Grabowski, R Graciani Diaz, L A Granado Cardoso, E Graugés, E Graverini, G Graziani, A Grecu, R Greim, P Griffith, L Grillo, L Gruber, B R Gruberg Cazon, O Grünberg, E Gushchin, Yu Guz, T Gys, C Göbel, T Hadavizadeh, C Hadjivasiliou, G Haefeli, C Haen, S C Haines, B Hamilton, X Han, T H Hancock, S Hansmann-Menzemer, N Harnew, S T Harnew, C Hasse, M Hatch, J He, M Hecker, K Heinicke, A Heister, K Hennessy, P Henrard, L Henry, E van Herwijnen, M Heß, A Hicheur, D Hill, P H Hopchev, W Hu, W Huang, Z C Huard, W Hulsbergen, T Humair, M Hushchyn, D Hutchcroft, P Ibis, M Idzik, P Ilten, R Jacobsson, J Jalocha, E Jans, A Jawahery, F Jiang, M John, D Johnson, C R Jones, C Joram, B Jost, N Jurik, S Kandybei, M Karacson, J M Kariuki, S Karodia, N Kazeev, M Kecke, F Keizer, M Kelsey, M Kenzie, T Ketel, E Khairullin, B Khanji, C Khurewathanakul, K E Kim, T Kirn, S Klaver, K Klimaszewski, T Klimkovich, S Koliiev, M Kolpin, R Kopecna, P Koppenburg, A Kosmyntseva, S Kotriakhova, M Kozeiha, L Kravchuk, M Kreps, F Kress, P Krokovny, W Krzemien, W Kucewicz, M Kucharczyk, V Kudryavtsev, A K Kuonen, T Kvaratskheliya, D Lacarrere, G Lafferty, A Lai, G Lanfranchi, C Langenbruch, T Latham, C Lazzeroni, R Le Gac, A Leflat, J Lefrançois, R Lefèvre, F Lemaitre, E Lemos Cid, O Leroy, T Lesiak, B Leverington, P-R Li, T Li, Y Li, Z Li, X Liang, T Likhomanenko, R Lindner, F Lionetto, V Lisovskyi, X Liu, D Loh, A Loi, I Longstaff, J H Lopes, D Lucchesi, M Lucio Martinez, H Luo, A Lupato, E Luppi, O Lupton, A Lusiani, X Lyu, F Machefert, F Maciuc, V Macko, P Mackowiak, S Maddrell-Mander, O Maev, K Maguire, D Maisuzenko, M W Majewski, S Malde, B Malecki, A Malinin, T Maltsev, G Manca, G Mancinelli, D Marangotto, J Maratas, J F Marchand, U Marconi, C Marin Benito, M Marinangeli, P Marino, J Marks, G Martellotti, M Martin, M Martinelli, D Martinez Santos, F Martinez Vidal, A Massafferri, R Matev, A Mathad, Z Mathe, C Matteuzzi, A Mauri, E Maurice, B Maurin, A Mazurov, M McCann, A McNab, R McNulty, J V Mead, B Meadows, C Meaux, F Meier, N Meinert, D Melnychuk, M Merk, A Merli, E Michielin, D A Milanes, E Millard, M-N Minard, L Minzoni, D S Mitzel, A Mogini, J Molina Rodriguez, T Mombächer, I A Monroy, S Monteil, M Morandin, M J Morello, O Morgunova, J Moron, A B Morris, R Mountain, F Muheim, M Mulder, D Müller, J Müller, K Müller, V Müller, P Naik, T Nakada, R Nandakumar, A Nandi, I Nasteva, M Needham, N Neri, S Neubert, N Neufeld, M Neuner, T D Nguyen, C Nguyen-Mau, S Nieswand, R Niet, N Nikitin, T Nikodem, A Nogay, D P O'Hanlon, A Oblakowska-Mucha, V Obraztsov, S Ogilvy, R Oldeman, C J G Onderwater, A Ossowska, J M Otalora Goicochea, P Owen, A Oyanguren, P R Pais, A Palano, M Palutan, G Panshin, A Papanestis, M Pappagallo, L L Pappalardo, W Parker, C Parkes, G Passaleva, A Pastore, M Patel, C Patrignani, A Pearce, A Pellegrino, G Penso, M Pepe Altarelli, S Perazzini, D Pereima, P Perret, L Pescatore, K Petridis, A Petrolini, A Petrov, M Petruzzo, E Picatoste Olloqui, B Pietrzyk, G Pietrzyk, M Pikies, D Pinci, F Pisani, A Pistone, A Piucci, V Placinta, S Playfer, M Plo Casasus, F Polci, M Poli Lener, A Poluektov, I Polyakov, E Polycarpo, G J Pomery, S Ponce, A Popov, D Popov, S Poslavskii, C Potterat, E Price, J Prisciandaro, C Prouve, V Pugatch, A Puig Navarro, H Pullen, G Punzi, W Qian, J Qin, R Quagliani, B Quintana, B Rachwal, J H Rademacker, M Rama, M Ramos Pernas, M S Rangel, I Raniuk, F Ratnikov, G Raven, M Ravonel Salzgeber, M Reboud, F Redi, S Reichert, A C Dos Reis, C Remon Alepuz, V Renaudin, S Ricciardi, S Richards, M Rihl, K Rinnert, P Robbe, A Robert, A B Rodrigues, E Rodrigues, J A Rodriguez Lopez, A Rogozhnikov, S Roiser, A Rollings, V Romanovskiy, A Romero Vidal, M Rotondo, M S Rudolph, T Ruf, P Ruiz Valls, J Ruiz Vidal, J J Saborido Silva, E Sadykhov, N Sagidova, B Saitta, V Salustino Guimaraes, C Sanchez Mayordomo, B Sanmartin Sedes, R Santacesaria, C Santamarina Rios, M Santimaria, E Santovetti, G Sarpis, A Sarti, C Satriano, A Satta, D M Saunders, D Savrina, S Schael, M Schellenberg, M Schiller, H Schindler, M Schmelling, T Schmelzer, B Schmidt, O Schneider, A Schopper, H F Schreiner, M Schubiger, M H Schune, R Schwemmer, B Sciascia, A Sciubba, A Semennikov, E S Sepulveda, A Sergi, N Serra, J Serrano, L Sestini, P Seyfert, M Shapkin, Y Shcheglov, T Shears, L Shekhtman, V Shevchenko, B G Siddi, R Silva Coutinho, L Silva de Oliveira, G Simi, S Simone, M Sirendi, N Skidmore, T Skwarnicki, I T Smith, J Smith, M Smith, L Soares Lavra, M D Sokoloff, F J P Soler, B Souza De Paula, B Spaan, P Spradlin, F Stagni, M Stahl, S Stahl, P Stefko, S Stefkova, O Steinkamp, S Stemmle, O Stenyakin, M Stepanova, H Stevens, S Stone, B Storaci, S Stracka, M E Stramaglia, M Straticiuc, U Straumann, S Strokov, J Sun, L Sun, K Swientek, V Syropoulos, T Szumlak, M Szymanski, S T'Jampens, A Tayduganov, T Tekampe, G Tellarini, F Teubert, E Thomas, J van Tilburg, M J Tilley, V Tisserand, M Tobin, S Tolk, L Tomassetti, D Tonelli, R Tourinho Jadallah Aoude, E Tournefier, M Traill, M T Tran, M Tresch, A Trisovic, A Tsaregorodtsev, P Tsopelas, A Tully, N Tuning, A Ukleja, A Usachov, A Ustyuzhanin, U Uwer, C Vacca, A Vagner, V Vagnoni, A Valassi, S Valat, G Valenti, R Vazquez Gomez, P Vazquez Regueiro, S Vecchi, M van Veghel, J J Velthuis, M Veltri, G Veneziano, A Venkateswaran, T A Verlage, M Vernet, M Vesterinen, J V Viana Barbosa, D Vieira, M Vieites Diaz, H Viemann, X Vilasis-Cardona, M Vitti, V Volkov, A Vollhardt, B Voneki, A Vorobyev, V Vorobyev, C Voß, J A de Vries, C Vázquez Sierra, R Waldi, J Walsh, J Wang, Y Wang, D R Ward, H M Wark, N K Watson, D Websdale, A Weiden, C Weisser, M Whitehead, J Wicht, G Wilkinson, M Wilkinson, M Williams, M Williams, T Williams, F F Wilson, J Wimberley, M Winn, J Wishahi, W Wislicki, M Witek, G Wormser, S A Wotton, K Wyllie, Y Xie, M Xu, Q Xu, Z Xu, Z Xu, Z Yang, Z Yang, Y Yao, H Yin, J Yu, X Yuan, O Yushchenko, K A Zarebski, M Zavertyaev, L Zhang, Y Zhang, A Zhelezov, Y Zheng, X Zhu, V Zhukov, J B Zonneveld, S Zucchelli
A search for the rare decay Σ^{+}→pμ^{+}μ^{-} is performed using pp collision data recorded by the LHCb experiment at center-of-mass energies sqrt[s]=7 and 8 TeV, corresponding to an integrated luminosity of 3  fb^{-1}. An excess of events is observed with respect to the background expectation, with a signal significance of 4.1 standard deviations. No significant structure is observed in the dimuon invariant mass distribution, in contrast with a previous result from the HyperCP experiment. The measured Σ^{+}→pμ^{+}μ^{-} branching fraction is (2...
June 1, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29905846/5-formylcytosine-mediated-dna-protein-cross-links-block-dna-replication-and-induce-mutations-in-human-cells
#5
Shaofei Ji, Iwen Fu, Spandana Naldiga, Hongzhao Shao, Ashis K Basu, Suse Broyde, Natalia Y Tretyakova
5-Formylcytosine (5fC) is an epigenetic DNA modification introduced via TET protein-mediated oxidation of 5-methyl-dC. We recently reported that 5fC form reversible DNA-protein conjugates (DPCs) with histone proteins in living cells (Ji et al. (2017) Angew. Chem. Int. Ed., 56:14130-14134). We now examined the effects of 5fC mediated DPCs on DNA replication. Synthetic DNA duplexes containing site-specific DPCs between 5fC and lysine-containing proteins and peptides were subjected to primer extension experiments in the presence of human translesion synthesis DNA polymerases η and κ...
June 14, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29905769/serologic-follow-up-of-middle-east-respiratory-syndrome-coronavirus-cases-and-contacts-abu-dhabi-united-arab-emirates
#6
Farida Ismail Al Hosani, Lindsay Kim, Ahmed Khudhair, Huong Pham, Mariam Al Mulla, Zyad Al Bandar, Krishna Pradeep, Kheir Abou Elkheir, Stefan Weber, Mary Khoury, George Donnelly, Naima Younis, Feda El Saleh, Muna Abdalla, Hala Imambaccus, Lia M Haynes, Natalie J Thornburg, Jennifer L Harcourt, Congrong Miao, Azaibi Tamin, Aron J Hall, Elizabeth S Russell, Aaron M Harris, Craig Kiebler, Roger A Mir, Kimberly Pringle, Negar N Alami, Glen R Abedi, Susan I Gerber
Background: Although there is evidence of person-to-person transmission of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in household and healthcare settings, more data are needed to describe and better understand the risk factors and transmission routes in both settings, as well as the extent that disease severity affects transmission. Methods: A sero-epidemiological investigation was conducted among Middle East Respiratory Syndrome Coronavirus (MERS-CoV) case-patients and their household contacts to investigate transmission risk in Abu Dhabi, United Arab Emirates...
June 13, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29902727/live-attenuated-bivalent-measles-virus-derived-vaccines-targeting-middle-east-respiratory-syndrome-coronavirus-induce-robust-and-multifunctional-t-cell-responses-against-both-viruses-in-an-appropriate-mouse-model
#7
Bianca S Bodmer, Anna H Fiedler, Jan R H Hanauer, Steffen Prüfer, Michael D Mühlebach
Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to occur, making it one of the WHO´s targets for accelerated vaccine development. One vaccine candidate is based on live-attenuated measles virus (MV) vaccine encoding the MERS-CoV spike glycoprotein (MERS-S). MVvac2 -MERS-S(H) induces robust humoral and cellular immunity against MERS-S mediating protection. Here, the induction and nature of immunity after vaccination with MVvac2 -MERS-S(H) or novel MVvac2 -MERS-N were further characterized...
June 11, 2018: Virology
https://www.readbyqxmd.com/read/29901262/spreading-the-news-about-the-novel-conjugation-mechanism-in-streptomyces-bacteria
#8
Gregg S Pettis
The hallmark of mycelial spore-forming bacteria of the genus Streptomyces is their prolific production of antibiotics and other bioactive secondary metabolites as part of a complex morphological and physiological developmental program. They are further distinguished by a conjugation mechanism that differs substantially from the single-strand mode of DNA transfer via Type IV secretion, which is exhibited by numerous unicellular Gram-negative and Gram-positive bacteria. At the crux of the novel intermycelial transfer event in Streptomyces spp...
June 14, 2018: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/29899673/new-species-of-eurycletodes-sars-1909-and-odiliacletodes-soyer-1964-from-the-deep-gulf-of-california-copepoda-harpacticoida-argestidae
#9
Samuel Gómez
To date, three species of the family Ancorabolidae, three species of the family Argestidae, and one species of the family Rhizothrichidae are known from the deep sea of the Gulf of California. The descriptions of two new species, Eurycletodes paraephippiger sp. n. and Odiliacletodes secundus sp. n. collected from the Southern Trough of Guaymas Basin at 1440 m and 1642 m depths, respectively, are presented herein. The closest relatives of these two species, E. ephippiger Por, 1964 and O. gracilis Soyer, 1964 are known from the Mediterranean, but some relatives have been reported also from the southern Atlantic...
2018: ZooKeys
https://www.readbyqxmd.com/read/29897404/progression-free-survival-at-24-months-pfs24-and-subsequent-outcome-for-patients-with-diffuse-large-b-cell-lymphoma-dlbcl-enrolled-on-randomized-clinical-trials
#10
M J Maurer, T M Habermann, Q Shi, N Schmitz, D Cunningham, M Pfreundschuh, J F Seymour, U Jaeger, C Haioun, H Tilly, H Ghesquieres, F Merli, M Ziepert, R Herbrecht, J Flament, T Fu, C R Flowers, B Coiffier
Background: Patients with diffuse large B-cell lymphoma treated with first-line anthracycline based immunochemotherapy and remaining in remission at two years have excellent outcomes. This study assessed overall survival (OS) stratified by progression-free survival at 24 months (PFS24) using individual patient data from patients with DLBCL enrolled in multi-center, international randomized clinical trials as part of the SEAL collaboration. Patients and Methods: PFS24 was defined as being alive and progression-free 24 months after study entry...
June 12, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29897334/association-mapping-from-sequencing-reads-using-k-mers
#11
Atif Rahman, Ingileif Hallgrímsdóttir, Michael Eisen, Lior Pachter
Genome wide association studies (GWAS) rely on microarrays, or more recently mapping of sequencing reads, to genotype individuals. The reliance on prior sequencing of a reference genome limits the scope of association studies, and also precludes mapping associations outside of the reference. We present an alignment free method for association studies of categorical phenotypes based on counting k -mers in whole-genome sequencing reads, testing for associations directly between k -mers and the trait of interest, and local assembly of the statistically significant k -mers to identify sequence differences...
June 13, 2018: ELife
https://www.readbyqxmd.com/read/29896174/a-rapid-and-specific-assay-for-the-detection-of-mers-cov
#12
Pei Huang, Hualei Wang, Zengguo Cao, Hongli Jin, Hang Chi, Jincun Zhao, Beibei Yu, Feihu Yan, Xingxing Hu, Fangfang Wu, Cuicui Jiao, Pengfei Hou, Shengnan Xu, Yongkun Zhao, Na Feng, Jianzhong Wang, Weiyang Sun, Tiecheng Wang, Yuwei Gao, Songtao Yang, Xianzhu Xia
Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel human coronavirus that can cause human respiratory disease. The development of a detection method for this virus that can lead to rapid and accurate diagnosis would be significant. In this study, we established a nucleic acid visualization technique that combines the reverse transcription loop-mediated isothermal amplification technique and a vertical flow visualization strip (RT-LAMP-VF) to detect the N gene of MERS-CoV. The RT-LAMP-VF assay was performed in a constant temperature water bath for 30 min, and the result was visible by the naked eye within 5 min...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29893124/electroactivity-of-aptamer-at-soft-microinterface-arrays
#13
Bren Mark B Felisilda, Damien W M Arrigan
The electrochemical behavior of a synthetic oligonucleotide, thrombin-binding aptamer (TBA, 15-mer), was explored at a liquid-organogel microinterface array. TBA did not display any response when only background electrolytes were present in both phases. Based on literature reports that surfactants can influence nucleic acid detection, the response in the presence of cetyltrimethylammo-nium (CTA+) was examined. With both TBA and CTA+ in the aqueous phase, the transfer current for CTA+ was diminished, signify-ing the interaction of CTA+ with TBA...
June 12, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29892209/correlation-between-pneumonia-severity-and-pulmonary-complications-in-middle-east-respiratory-syndrome
#14
Wan Beom Park, Kang Il Jun, Gayeon Kim, Jae-Phil Choi, Ji-Young Rhee, Shinhyea Cheon, Chang Hyun Lee, Jun-Sun Park, Yeonjae Kim, Joon-Sung Joh, Bum Sik Chin, Pyeong Gyun Choe, Ji Hwan Bang, Sang-Won Park, Nam Joong Kim, Dong-Gyun Lim, Yeon-Sook Kim, Myoung-Don Oh, Hyoung-Shik Shin
This nationwide, prospective cohort study evaluated pulmonary function and radiological sequelae according to infection severity in 73 survivors from the 2015 Middle East respiratory syndrome (MERS) outbreak in Korea. Patients with severe pneumonia in MERS-coronavirus infection had more impaired pulmonary function than those with no or mild pneumonia at the 1-year follow-up, which was compatible with the radiological sequelae. Severe pneumonia significantly impairs pulmonary function and makes long radiological sequelae in MERS...
June 11, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29891987/optimization-of-assembly-pipeline-may-improve-the-sequence-of-the-chloroplast-genome-in-quercus-spinosa
#15
Xiangzhou Zhang, Yong Hu, Mei Liu, Tiange Lang
Obtaining chloroplast (cp) genome sequence is necessary for studying physiological roles in plants. However, it is difficult to use traditional sequencing methods to get cp genome sequences because of the complex procedures of preparing templates. With the advent of next-generation sequencing technology, massive genome sequences can be produced. Thus, a good pipeline to assemble next-generation sequence reads with optimized k-mer length is essential to get whole cp genome sequences. Moreover, adjustment of other parameters is also very important, especially for the assembly of the cp genome...
June 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29891486/stat3-cyclic-decoy-demonstrates-robust-antitumor-effects-in-non-small-cell-lung-cancer
#16
Christian Njatcha, Mariya Farooqui, Adam Kornberg, Daniel E Johnson, Jennifer R Grandis, Jill M Siegfried
Constitutively activated STAT3 plays a critical role in non-small cell lung carcinoma (NSCLC) progression by mediating proliferation and survival. STAT 3 activation in normal cells is transient, making it an attractive target for NSCLC therapy. The therapeutic potential of blocking STAT3 in NSCLC was assessed utilizing a decoy approach by ligating a double-stranded 15-mer oligonucleotide that corresponds to the STAT3 response element of STAT3-target genes, to produce a cyclic STAT3 decoy (CS3D). The decoy was evaluated using NSCLC cells containing either wild-type (WT) EGFR (201T) or mutant EGFR with an additional EGFRi resistance mutation (H1975)...
June 11, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29889829/humoral-and-cellular-immune-responses-to-yersinia-pestis-pla-antigen-in-humans-immunized-with-live-plague-vaccine
#17
Valentina A Feodorova, Anna M Lyapina, Maria A Khizhnyakova, Sergey S Zaitsev, Lidiya V Sayapina, Tatiana E Arseneva, Alexey L Trukhachev, Svetlana A Lebedeva, Maxim V Telepnev, Onega V Ulianova, Elena P Lyapina, Sergey S Ulyanov, Vladimir L Motin
BACKGROUND: To establish correlates of human immunity to the live plague vaccine (LPV), we analyzed parameters of cellular and antibody response to the plasminogen activator Pla of Y. pestis. This outer membrane protease is an essential virulence factor that is steadily expressed by Y. pestis. METHODOLOGY/PRINCIPAL FINDINGS: PBMCs and sera were obtained from a cohort of naïve (n = 17) and LPV-vaccinated (n = 34) donors. Anti-Pla antibodies of different classes and IgG subclasses were determined by ELISA and immunoblotting...
June 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29887526/middle-east-respiratory-syndrome-coronavirus-and-bat-coronavirus-hku9-both-can-utilize-grp78-for-attachment-onto-host-cells
#18
Hin Chu, Che-Man Chan, Xi Zhang, Yixin Wang, Shuofeng Yuan, Jie Zhou, Rex Kwok-Him Au-Yeung, Kong-Hung Sze, Dong Yang, Huiping Shuai, Yuxin Hou, Cun Li, Xiaoyu Zhao, Vincent Kwok-Man Poon, Sze-Pui Leung, Man-Lung Yeung, Jinghua Yan, Guangwen Lu, Dong-Yan Jin, George Fu Gao, Jasper Fuk-Woo Chan, Kwok-Yung Yuen
Coronavirus tropism is predominantly determined by the interaction between coronavirus spikes and the host receptors. In this regard, coronaviruses have evolved a complicated receptor-recognition system through their spike proteins. Spikes from highly related coronaviruses can recognize distinct receptors, whereas spikes of distant coronaviruses can employ the same cell-surface molecule for entry. Moreover, coronavirus spikes can recognize a broad range of cell-surface molecules in addition to the receptors and thereby can augment coronavirus attachment or entry...
June 10, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29886854/underlying-trend-seasonality-prediction-forecasting-and-the-contribution-of-risk-factors-an-analysis-of-globally-reported-cases-of-middle-east-respiratory-syndrome-coronavirus
#19
Omar B Da'ar, Anwar E Ahmed
This study set out to identify and analyse trends and seasonal variations of monthly global reported cases of the Middle East respiratory syndrome coronavirus (MERS-CoV). It also made a prediction based on the reported and extrapolated into the future by forecasting the trend. Finally, the study assessed contributions of various risk factors in the reported cases. The motivation for this study is that MERS-CoV remains among the list of blueprint priority and potential pandemic diseases globally. Yet, there is a paucity of empirical literature examining trends and seasonality as the available evidence is generally descriptive and anecdotal...
June 11, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29886735/differentiating-parallel-and-antiparallel-dna-duplexes-in-the-gas-phase-using-trapped-ion-mobility-spectrometry
#20
David Butcher, Prem P Chapagain, Fenfei Leng, Francisco Fernandez-Lima
Deoxyribonucleic acids can form a wide variety of structural motifs which differ greatly from the typical antiparallel duplex stabilized by Watson-Crick base pairing. Many of these structures are thought to occur in vivo and may have essential roles in the biology of the cell. Among these is the parallel-stranded duplex - a structural motif in which DNA strands associate in a head-to-head fashion with the 5' ends at the same end of the duplex which is stabilized by reverse Watson-Crick base pairing. In this study, parallel- and antiparallel- stranded DNA duplexes formed from two different 12-mer oligonucleotides were studied using native electrospray ionization combined with trapped ion mobility spectrometry and mass spectrometry (TIMS-MS)...
June 11, 2018: Journal of Physical Chemistry. B
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