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methicillin resistant staphylococcus aureus

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https://www.readbyqxmd.com/read/28811083/phenotypic-chlorhexidine-and-triclosan-susceptibility-in-clinical-staphylococcus-aureus-isolates-in-australia
#1
C Hughes, J Ferguson
Antiseptics such as chlorhexidine gluconate and triclosan are widely used in healthcare settings for both skin antisepsis and decolonisation of Staphylococcus aureus. We determined the minimum inhibitory concentration (MIC) of 198 methicillin susceptible and resistant Staphylococcus aureus clinical isolates to both chlorhexidine and triclosan using an agar dilution method. Of these, 10% (19/198) showed a raised MIC to chlorhexidine and 3% (6/198) showed an elevated MIC to triclosan. The multilocus sequence type (MLST) of each isolate was predicted using a binary method, and although ST93-MRSA-IV was the most common, ST22-MRSA-IV was shown to have statistically higher chlorhexidine MIC values compared with non ST22-MRSA-IV isolates (z = -8...
August 12, 2017: Pathology
https://www.readbyqxmd.com/read/28810309/-the-clinical-value-of-genotypic-diagnosis-and-current-state-of-community-acquired-methicillin-resistant-staphylococcus-aureus-pneumonia
#2
B He, W Q Diao, N Shen
No abstract text is available yet for this article.
August 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28810233/an-ultrasensitive-electrochemical-biosensor-for-the-detection-of-meca-gene-in-methicillin-resistant-staphylococcus-aureus
#3
Li Xu, Wen Liang, Yanli Wen, Lele Wang, Xue Yang, Shuzhen Ren, Nengqin Jia, Xiaolei Zuo, Gang Liu
Electrochemical DNA biosensor has unique advantages for on-site pathogenic microorganism detection, yet the detection of long DNA towards genome DNA (gDNA) analysis remains challenge. In this work, we report a novel electrochemical biosensor for the ultrasensitive analysis of mecA DNA on methicillin-resistant Staphylococcus aureus (MRSA) genome, using a multi-signal probes (MSP) system. The MSP consists of 7 biotin-labelled signal probes that will combine to the target DNA in a prehybridization step, and then the complex will be captured by a DNA tetrahedron structure probe (TSP) on the electrode surface...
August 8, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28810104/strategies-for-prevention-of-methicillin-resistant-staphylococcus-aureus-mrsa-infections-and-decolonization
#4
Ashlesha Kaushik, Cassie Wagner, Hollie Consoer, Archana Chatterjee
Methicillin resistant Staphylococcus aureus (MRSA) invasive infections can be severe in the pediatric population with high morbidity and mortality. MRSA colonization can predispose to recurrent skin and soft tissue infections and invasive MRSA disease and is a frequent challenge faced by clinicians. This article reviews the importance of MRSA as a pathogen, MRSA colonization and various MRSA decolonization strategies.
December 2016: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28808911/methicillin-resistant-staphylococcus-aureus-acute-keratitis-after-intracorneal-ring-segment-implantation
#5
Gonzalo García de Oteyza, Andrea Laiseca, Paola Sauvageot, Juan Álvarez de Toledo
INTRODUCTION: The purpose of this study was to report the first case of acute bacterial keratitis produced by methicillin-resistant Staphylococcus aureus after the implantation of two intracorneal ring segments during an uneventful procedure for treating keratoconus in a 13-year-old child. CASE REPORT: A patient with grade III keratoconus underwent an implantation of intracorneal ring segments with no complications during the procedure. Three days later, a whitish corneal infiltrate appeared in between the union of both corneal rings...
August 14, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28807228/antibacterial-steroidal-alkaloids-from-holarrhena-antidysenteriaca
#6
Li-Na Zhou, Xiao-Lei Ge, Ting-Ting Dong, Hui-Yuan Gao, Bo-Hang Sun
Two new steroidal alkaloids, isoconkuressine and N-formylconessimine, together with 6 known steroidal alkaloids including conkuressine, conessine, isoconessimine, conimine, conarrhimine, and funtudienine, were isolated from the seeds of Holarrhena antidysenteriaca Wall.ex A.DC. Their intrinsic antibacterial activities and synergistic effects with penicillin and vancomycin were analyzed in methicillin sensitive staphylococcus aureus (MSSA) and methicillin resistant staphylococcus aureus (MRSA). Two of the steroidal alkaloids including one new compound (N-formylconessimine) showed potential antibacterial activity and possessed synergistic effects with penicillin and vancomycin, respectively...
July 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28807097/genotypic-characterization-of-methicillin-resistant-staphylococcus-aureus-isolated-from-pigs-and-retail-foods-in-china
#7
Wei Wang, Feng Liu, Zulqarnain Baloch, Cun Shan Zhang, Ke Ma, Zi Xin Peng, Shao Fei Yan, Yu Jie Hu, Xin Gan, Yin Ping Dong, Yao Bai, Feng Qin Li, Xiao Mein Yan, Ai Guo Ma, Jin Xu
OBJECTIVE: To investigate the genotypic diversity of Methicillin-resistant Staphylococcus aureus (MRSA) isolated from pigs and retail foods from different geographical areas in China and further to study the routes and rates of transmission of this pathogen from animals to food. METHODS: Seventy-one MRSA isolates were obtained from pigs and retail foods and then characterized by multi-locus sequencing typing (MLST), spa typing, multiple-locus variable number of tandem repeat analysis (MLVA), pulsed-field gel electrophoresis (PFGE), and antimicrobial susceptibility testing...
August 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28807042/incidence-prevalence-and-management-of-mrsa-bacteremia-across-patient-populations-a-review-of-recent-developments-in-mrsa-management-and-treatment
#8
REVIEW
Ali Hassoun, Peter K Linden, Bruce Friedman
Methicillin-resistant Staphylococcus aureus (MRSA) infection is still a major global healthcare problem. Of concern is S. aureus bacteremia, which exhibits high rates of morbidity and mortality and can cause metastatic or complicated infections such as infective endocarditis or sepsis. MRSA is responsible for most global S. aureus bacteremia cases, and compared with methicillin-sensitive S. aureus, MRSA infection is associated with poorer clinical outcomes. S. aureus virulence is affected by the unique combination of toxin and immune-modulatory gene products, which may differ by geographic location and healthcare- or community-associated acquisition...
August 14, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28806528/surface-adaptive-gold-nanoparticles-with-effective-adherence-and-enhanced-photothermal-ablation-of-methicillin-resistant-staphylococcus-aureus-biofilm
#9
Dengfeng Hu, Huan Li, Bailiang Wang, Zi Ye, Wenxi Lei, Fan Jia, Qiao Jin, Ke-Feng Ren, Jian Ji
Biofilms which contribute to the persistent bacterial infections pose serious threats to global public health, mainly due to their resistance to antibiotics penetration and escaping innate immune attacks by phagocytes. Here, we report a kind of surface-adaptive gold nanoparticles (AuNPs) exhibiting (1) self-adaptive target to the acidic microenvironment of biofilm, (2) enhanced photothermal ablation of methicillin-resistant Staphylococcus aureus (MRSA) biofilm under near-infrared (NIR) light irradiation and (3) no damage to the healthy tissues around biofilm...
August 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/28804601/policy-implementation-for-methicillin-resistant-staphylococcus-aureus-in-seven-european-countries-a-comparative-analysis-from-1999-to-2015
#10
Takuya Kinoshita, Hironobu Tokumasu, Shiro Tanaka, Axel Kramer, Koji Kawakami
Background: Policies to reduce methicillin-resistant Staphylococcus aureus (MRSA) infections, both healthcare-acquired (HA-MRSA) and livestock-associated (LA-MRSA) are implemented Europe-wide, but evaluations are difficult for countries yet to implement such policies. A descriptive study was conducted, describing multinational MRSA rates and policy implementation, focusing on MRSA mandatory surveillance. We also investigated antibiotic use and MRSA rates and the use of veterinary antibiotics. Methods: This study used Europe-wide surveillance data on infectious diseases (EARS-Net), antibiotic consumption (ESAC-Net), and veterinary medicine (ESVAC)...
2017: Journal of Market Access & Health Policy
https://www.readbyqxmd.com/read/28804007/antibiotic-therapy-duration-for-prosthetic-joint-infections-treated-by-debridement-and-implant-retention-dair-similar-long-term-remission-for-6-weeks-as-compared-to-12-weeks
#11
Hélène Chaussade, Ilker Uçkay, Albert Vuagnat, Jérôme Druon, Guillaume Gras, Philippe Rosset, Benjamin A Lipsky, Louis Bernard
BACKGROUND: The required duration of antibiotic treatment for prosthetic joint infections (PJI) with debridement and retention of the implant (DAIR procedure) is unknown. METHODS: Multicenter retrospective study emphasizing the duration of antibiotic therapy in patients treated with by DAIR. RESULTS: We included 87 hip or knee PJI episodes in 87 patients from three university hospitals in France and Switzerland. All debridements were performed within 3 weeks of symptom onset...
August 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28803995/depsidones-and-an-%C3%AE-pyrone-derivative-from-simpilcillium-sp-psu-h41-an-endophytic-fungus-from-hevea-brasiliensis-leaf
#12
Praphatsorn Saetang, Vatcharin Rukachaisirikul, Souwalak Phongpaichit, Sita Preedanon, Jariya Sakayaroj, Suparerk Borwornpinyo, Sawinee Seemakhan, Chatchai Muanprasat
Nine previously undescribed depsidones (simplicildones A-I) and one previously undescribed α-pyrone (simplicilopyrone) were isolated from the endophytic fungus Simplicillium sp. PSU-H41 along with 11 known compounds. Their structures were established by extensive spectroscopic analysis. Simplicildone A and known botryorhodine C displayed weak antibacterial against Staphylococcus aureus with equal MIC values of 32 μg/mL. Additionally, botryorhodine C was active against methicillin-resistant S. aureus with the same MIC value...
August 9, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28803587/the-rise-of-methicillin-resistant-staphylococcus-aureus-now-the-dominant-cause-of-skin-and-soft-tissue-infection-in-central-australia
#13
E Macmorran, S Harch, E Athan, S Lane, S Tong, L Crawford, S Krishnaswamy, S Hewagama
This study aimed to examine the epidemiology and treatment outcomes of community-onset purulent staphylococcal skin and soft tissue infections (SSTI) in Central Australia. We performed a prospective observational study of patients hospitalised with community-onset purulent staphylococcal SSTI (n = 160). Indigenous patients accounted for 78% of cases. Patients were predominantly young adults; however, there were high rates of co-morbid disease. Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) was the dominant phenotype, accounting for 60% of cases...
August 14, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28802716/presence-of-modic-type-1-change-increases-risk-of-postoperative-pyogenic-discitis-following-decompression-surgery-for-lumbar-canal-stenosis
#14
Ken Ninomiya, Nobuyuki Fujita, Naobumi Hosogane, Tomohiro Hikata, Kota Watanabe, Osahiko Tsuji, Narihito Nagoshi, Mitsuru Yagi, Shinjiro Kaneko, Yasuyuki Fukui, Takahiro Koyanagi, Tateru Shiraishi, Takashi Tsuji, Masaya Nakamura, Morio Matsumoto, Ken Ishii
STUDY DESIGN: Multicenter retrospective study. BACKGROUND: Postoperative surgical site infection is one of the most serious complications following spine surgery. Previous studies do not appear to have investigated pyogenic discitis following lumbar laminectomy without discectomy. This study aimed to identify risk factors for postoperative pyogenic discitis following lumbar decompression surgery. METHODS: We examined data from 2721 patients undergoing lumbar laminectomy without discectomy in five hospitals from April 2007 to March 2012...
August 10, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28802058/postantibiotic-effect-and-postantibiotic-sub-mic-effect-of-ltx-109-and-mupirocin-on-staphylococcus-aureus-blood-isolates
#15
Louis D Saravolatz, Joan Pawlak, Hayley Martin, Stephanie Saravolatz, Leonard Johnson, Hedda Wold, Mette Husbyn, Wenche Marie Olsen
The development of new synthetic antimicrobial peptides like LTX-109 provides a new class of drugs for the treatment of Staphylococcus aureus infections. We evaluated LTX-109 and mupirocin for pharmacodynamic parameters against 10 methicillin-resistant S. aureus isolates. The post antibiotic effect (PAE) is defined as the length of time that bacterial growth is suppressed following a brief exposure to an antibiotic. We also determined the sub-MIC effect (SME) which measures the direct effect of sub-inhibitory levels on strains that have not previously been exposed to antibiotics...
August 12, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28800818/characterization-of-a-novel-endolysin-lyssa11-and-its-utility-as-a-potent-biocontrol-agent-against-staphylococcus-aureus-on-food-and-utensils
#16
Yoonjee Chang, Minsik Kim, Sangryeol Ryu
Here we show that the LysSA11 endolysin, derived from the virulent Staphylococcus aureus phage SA11, has lytic activity against staphylococcal strains. Bioinformatics analysis revealed an enzymatically active CHAP (cysteine, histidine-dependent amidohydrolases/peptidases) domain at the N-terminus of LysSA11 that showed amidase activity. A novel cell wall binding domain (CBD) in the C-terminus could bind to a broad spectrum of staphylococcal cells. The bactericidal activity of LysSA11 was determined in food and utensils artificially contaminated with methicillin-resistant S...
December 2017: Food Microbiology
https://www.readbyqxmd.com/read/28800088/upregulation-and-identification-of-antibiotic-activity-of-a-marine-derived-streptomyces-sp-via-co-cultures-with-human-pathogens
#17
Anne A Sung, Samantha M Gromek, Marcy J Balunas
Marine natural product drug discovery has begun to play an important role in the treatment of disease, with several recently approved drugs. In addition, numerous microbial natural products have been discovered from members of the order Actinomycetales, particularly in the genus Streptomyces, due to their metabolic diversity for production of biologically active secondary metabolites. However, many secondary metabolites cannot be produced under laboratory conditions because growth conditions in flask culture differ from conditions in the natural environment...
August 11, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28799881/prevalence-and-microbiological-characteristics-of-qaca-b-positive-methicillin-resistant-staphylococcus-aureus-isolates-in-a-surgical-intensive-care-unit
#18
Oh-Hyun Cho, Ki-Ho Park, Ji Young Song, Jeong Min Hong, Taeeun Kim, Sun In Hong, Sunjoo Kim, In-Gyu Bae
The increasing use of chlorhexidine for methicillin-resistant Staphylococcus aureus (MRSA) decolonization has raised concerns about the emergence of resistance to or tolerance of this antiseptic. We examined the frequency and characteristics of qacA/B chlorhexidine tolerance genes among MRSA isolates in a surgical intensive care unit (ICU) where MRSA-colonized patients are decolonized by chlorhexidine bathing. The MRSA isolates were evaluated for chlorhexidine susceptibility, mupirocin resistance, molecular typing, agr functionality, and the heterogeneous vancomycin-intermediate S...
August 11, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28799789/naphtho-1-2-b-furan-4-5-dione-is-a-potent-anti-mrsa-agent-against-planktonic-biofilm-and-intracellular-bacteria
#19
Shih-Chun Yang, Feng-Lin Yen, Pei-Wen Wang, Ibrahim A Aljuffali, Yi-Han Weng, Chih-Hua Tseng, Jia-You Fang
AIM: Naphtho[1,2-b]furan-4,5-dione (N12D) and naphtho[2,3-b]furan-4,9-dione (N23D) are furanonaphthoquinone derivatives from natural resources. We examined the antimicrobial activity of N12D and N23D against drug-resistant Staphylococcus aureus. MATERIALS & METHODS: Minimum inhibitory concentration, minimum bactericidal concentration, bacterial viability and agar diffusion assay were conducted against methicillin-resistant S. aureus (MRSA) and clinical isolates of vancomycin-resistant S...
August 11, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28799332/attaching-the-nora-efflux-pump-inhibitor-inf55-to-methylene-blue-enhances-antimicrobial-photodynamic-inactivation-of-methicillin-resistant-staphylococcus-aureus-in-vitro-and-in-vivo
#20
Ardeshir Rineh, Naveen K Dolla, Anthony R Ball, Maria Magana, John B Bremner, Michael R Hamblin, George P Tegos, Michael J Kelso
Antimicrobial photodynamic inactivation (aPDI) uses photosensitizers (PSs) and harmless visible light to generate reactive oxygen species (ROS) and kill microbes. Multidrug efflux systems can moderate the phototoxic effects of PSs by expelling the compounds from cells. We hypothesized that increasing intracellular concentrations of PSs by inhibiting efflux with a covalently attached efflux pump inhibitor (EPI) would enhance bacterial cell phototoxicity and reduce exposure of neighbouring host cells to damaging ROS...
August 11, 2017: ACS Infectious Diseases
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