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central line associated bloodstream infection

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https://www.readbyqxmd.com/read/29927699/international-experience-with-minocycline-edta-and-ethanol-lock-for-salvaging-of-central-line-associated-bloodstream-infections
#1
Ray Hachem, Souha Kanj, Nelson Hamerschlak, Hala Saad, Fernanda Ferraz Assir, Nobuyoshi Mori, Ying Jiang, Fady Ghaly, Anne Marie Chaftari, Issam I Raad
BACKGROUND: The use of long-term central venous catheters (CVCs) could lead to serious bloodstream infections. Removal of the infected CVC and reinsertion of a new CVC are not always feasible and alternative lock therapy may be considered. We conducted a multicenter trial to assess the efficacy and safety of the lock therapy. METHODS: Between October 2013 and August 2014, we prospectively enrolled 20 patients with catheter-related bloodstream infections (CRBSIs) or central line-associated bloodstream infections (CLABSIs) in our sister institutions in three countries including Brazil, Lebanon, and Japan...
June 2018: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/29926785/central-line-bundle-for-prevention-of-central-line-associated-bloodstream-infection-for-totally-implantable-venous-access-devices-ports-in-pediatric-cancer-patients
#2
İlker Devrim, Yeliz Oruç, Bengü Demirağ, Ahu Kara, Mine Düzgöl, Selma Uslu, Nevbahar Yaşar, Sultan Aydın Köker, Ersin Töret, Nuri Bayram, Canan Vergin
OBJECTIVE: The clinical impact of central line bundle programs for central line-associated bloodstream infections has been well demonstrated in intensive care units. However, the experience of central line bundle programs in totally implantable venous access devices (ports) in pediatric-hematology patients was limited. METHODS: A retrospective study was designed to compare and evaluate the clinical impact of implementing a central line bundle for a 2-year 5-month period, including 10 months of prebundle period, 11 months of central line bundle (that includes needleless split-septum devices), and finally 8 months of central line bundle period in which single-use prefilled flushing devices were added to the previous central line bundle...
July 2018: Journal of Vascular Access
https://www.readbyqxmd.com/read/29923938/predictive-factors-for-central-line-associated-bloodstream-infections-in-pediatric-cardiac-surgery-patients-with-chylothorax
#3
Stephanie G Waterhouse, Jeffrey E Vergales, Mark R Conaway, Laura Lee
OBJECTIVES: To assess the prevalence of central line-associated bloodstream infections in pediatric patients with and without chylothorax after cardiac surgery and identify risk factors that predict those patients at highest risk for developing a central line-associated bloodstream infection. DESIGN: Retrospective single-center cohort study. SETTING: A PICU located within a tertiary-care academic pediatric hospital. PATIENTS: All pediatric patients admitted to the PICU after cardiac surgery between 2008 and 2014...
June 19, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29912033/analysis-of-healthcare-institutional-costs-of-pediatric-home-parenteral-nutrition-central-line-infections
#4
Bram P Raphael, Christina Hazenkamp, Mihail Samnaliev, Al Ozonoff
BACKGROUND: While previous literature suggests home parenteral nutrition (HPN) dependent children experience frequent complications like community acquired central line associated bloodstream infections (CLABSI), few studies have characterized the cost. OBJECTIVES: To evaluate institutional cost of community-acquired CLABSI in pediatric HPN patients. METHODS: This is a single center retrospective review of institutional costs for HPN patients with community-acquired CLABSI at a tertiary care children's hospital...
June 13, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29908838/a-new-frontier-central-line-associated-bloodstream-infection-surveillance-in-home-infusion-therapy
#5
Sara C Keller, Deborah Williams, Clare Rock, Shiv Deol, Polly Trexler, Sara E Cosgrove
No abstract text is available yet for this article.
June 13, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29903420/state-health-department-validations-of-central-line-associated-bloodstream-infection-events-reported-via-the-national-healthcare-safety-network
#6
REVIEW
Suparna Bagchi, Jennifer Watkins, Daniel A Pollock, Jonathan R Edwards, Katherine Allen-Bridson
BACKGROUND: Numerous state health departments (SHDs) have validated central line-associated bloodstream infection (CLABSI) data, and results from these studies provide important insights into the accuracy of CLABSI reporting to the National Healthcare Safety Network (NHSN) and remediable shortcomings in adherence to the CLABSI definition and criteria. METHODS: State CLABSI validation results were obtained from peer-reviewed publications, reports on SHD Web sites, and via personal communications with the SHD health care-associated infections coordinator...
June 11, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29894411/central-line-bundle-maintenance-among-adults-in-a-university-hospital-intensive-care-unit-in-s%C3%A3-o-paulo-brazil-a-best-practice-implementation-project
#7
Karina Sichieri, Luciana Inaba Senyer Iida, Isa Rodrigues da Silveira Cabral de Menezes, Paulo Carlos Garcia, Talita Raquel Santos, Emília Peres, Gilcéria Tochika Shimoda, Flávia de Oliveira Motta Maia, Silvia Regina Secoli, Vilanice Alves de Araújo Püschel
OBJECTIVES: This implementation project aimed to identify the current practice in regards to central venous catheters (CVCs) maintenance to improve knowledge amongst nursing staff and to assess increased compliance with evidence-based best practice. INTRODUCTION: Central venous catheters are considered an important therapeutic resource for the administration of fluids, drugs, blood, collection of blood samples and hemodynamic monitoring. Despite the benefits, catheter use is associated with complications such as primary infection of the catheter-related bloodstream...
June 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29888413/trends-in-late-onset-sepsis-in-a-neonatal-intensive-care-unit-following-implementation-of-infection-control-bundle-a-15-year-audit
#8
Pramod Pharande, Kwee B Lindrea, John Smyth, Margaret Evans, Kei Lui, Srinivas Bolisetty
AIM: Late-onset sepsis (LOS) is a frequent and important cause of morbidity and mortality in newborn infants admitted to neonatal intensive care units (NICUs). The objective of this study is to evaluate the impact of various infection control quality measures introduced as a bundle on the trends of the LOS in a NICU. METHODS: This was a prospective quality improvement study involving all neonates admitted to a NICU over a 15-year period between 2002 and 2016. The main focus areas of the bundle included collaborative team effort, hand hygiene, education, central line insertion and maintenance bundles and parenteral nutrition...
June 11, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29887034/corrigendum-to-antiseptic-barrier-cap-effective-in-reducing-central-line-associated-bloodstream-infections-a-systematic-review-and-meta-analysis-int-j-nurs-stud-69-2017-34-40
#9
Anne F Voor In 't Holt, Onno K Helder, Margreet C Vos, Laura Schafthuizen, Sandra Sülz, Agnes van den Hoogen, Erwin Ista
No abstract text is available yet for this article.
August 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29884572/treatment-and-secondary-prophylaxis-with-ethanol-lock-therapy-for-central-line-associated-bloodstream-infection-in-paediatric-cancer-a-randomised-double-blind-controlled-trial
#10
Joshua Wolf, Tom G Connell, Kim J Allison, Li Tang, Julie Richardson, Kristen Branum, Eloise Borello, Jeffrey E Rubnitz, Aditya H Gaur, Hana Hakim, Yin Su, Sara M Federico, Francoise Mechinaud, Randall T Hayden, Paul Monagle, Leon J Worth, Nigel Curtis, Patricia M Flynn
BACKGROUND: Central line-associated bloodstream infections (CLABSIs) affect about 25% of children with cancer, and treatment failure is common. Adjunctive ethanol lock therapy might prevent treatment failure but high-quality evidence is scarce. We evaluated ethanol lock therapy as treatment and secondary prophylaxis for CLABSI in children with cancer or haematological disorders. METHODS: This randomised, double-blind, placebo-controlled superiority trial, with two interim futility and efficacy analyses (done when the first 46 and 92 evaluable participants completed study requirements), was done at two paediatric hospitals in the USA and Australia...
June 5, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29884118/efficacy-of-introducing-a-checklist-to-reduce-central-venous-line-associated-bloodstream-infections-in-the-icu-caring-for-adult-patients
#11
Dominic Wichmann, Cristina E Belmar Campos, Stephan Ehrhardt, Timo Kock, Claudia Weber, Holger Rohde, Stefan Kluge
BACKGROUND: Central line-associated bloodstream infections (CLABSI) are a major source of sepsis in modern intensive care medicine. Some years ago bundle interventions have been introduced to reduce CLABSI. The use of checklists may be an additional tool to improve the effect of these bundles even in highly specialized institutions. In this study we investigate if the introduction of a checklist reduces the frequency of CLABSI. METHODS: During the study period from October 2011 to September 2012, we investigated the effect of implementing a checklist for the placement of central venous lines (CVL)...
June 8, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29875106/preventing-central-line-associated-bloodstream-infection-in-pediatric-oncology-care
#12
Elizabeth A Duffy, Margaret Rabatin
No abstract text is available yet for this article.
2018: AACN Advanced Critical Care
https://www.readbyqxmd.com/read/29870516/multicenter-study-of-device-associated-infection-rates-bacterial-resistance-length-of-stay-and-mortality-in-intensive-care-units-of-2-cities-of-vietnam-international-nosocomial-infection-control-consortium-findings
#13
Nguyen Viet Hung, Phan Thi Hang, Victor D Rosenthal, Le Thi Anh Thu, Le Thi Thu Nguyet, Ngo Quy Chau, Truong Anh Thu, Dinh Pham Phuong Anh, Tran Thi My Hanh, Tran Thi Thuy Hang, Dang Thi Van Trang, Nguyen Phuc Tien, Vo Thi Hong Thoa, Đao Quang Minh
OBJECTIVE: The aim of the study was to report the results of the International Nosocomial Infection Control Consortium (INICC) study conducted from May 2008 to March 2015. METHODS: A device-associated healthcare-acquired infection surveillance study in three adult intensive care units (ICUs) and 1 neonatal ICU from 4 hospitals in Vietnam using U.S. the Centers for Disease Control and Prevention's National Healthcare Safety Network (CDC/NHSN) definitions and criteria as well as INICC methods...
June 4, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29866870/-in-vitro-and-in-vivo-activity-of-a-novel-catheter-lock-solution-against-bacterial-and-fungal-biofilms
#14
J Chandra, L Long, N Isham, P K Mukherjee, G DiSciullo, K Appelt, M A Ghannoum
Central line associated bloodstream infections (CLABSIs) are increasingly recognized to be associated with intralumenal microbial biofilms, and effective measures for the prevention and treatment of BSI remain lacking. This report evaluates a new commercially developed antimicrobial catheter lock solution (ACL) containing trimethoprim (5 mg/ml) and ethanol (25%) and calcium Ethylenediaminetetraacetic acid (CA-EDTA) 3% for activity against bacterial and fungal biofilms using in vitro and in vivo (rabbit) catheter biofilm models...
June 4, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29805057/achieving-balance-between-implementing-effective-infection-prevention-and-control-practices-and-maintaining-a-home-like-setting-in-u-s-department-of-veterans-affairs-nursing-homes
#15
Marla Clifton, Stephen M Kralovic, Loretta A Simbartl, Lisa Minor, Rachael Hasselbeck, Tina Martin, Gary A Roselle
Nursing homes present a unique challenge for implementing infection prevention and control practices while striving to maintain a home-like environment. Medical devices such as urinary catheters and central venous catheters have become a part of nursing home care but can predispose residents to associated infections. Because evidence-based prevention bundles were implemented, catheter-associated urinary tract infections (CAUTIs) and central line-associated bloodstream infections (CLABSIs) were monitored in all U...
May 24, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29793883/reducing-serious-safety-events-and-priority-hospital-acquired-conditions-in-a-pediatric-hospital-with-the-implementation-of-a-patient-safety-program
#16
Amber R Phipps, Melisa Paradis, Kimberly A Peterson, Jill Jensen, Katie Nielsen, Mel Hall, Kari Simonsen, Bridget M Norton
BACKGROUND: A freestanding children's hospital evaluated the impact of a patient safety program on serious safety events (SSEs) and hospital-acquired conditions (HACs). METHODS: The No Harm Patient Safety Program was developed throughout the organization using a multifaceted approach that included safety moments, leadership rounding, cause analysis changes, event reporting enhancements, error prevention training, leadership training, identifying priority HACs, Eye on Safety Campaign, and safety coaches...
June 2018: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/29778436/enhanced-central-venous-catheter-bundle-for-pediatric-parenteral-dependent-intestinal-failure
#17
Jennifer A Ormsby, Bola Bukoye, Debra Lajoie, Herminia Shermont, Lisa Martin, Kierrah Leger, Judy Mahoney, Gail Potter-Bynoe, Jane Carpenter, Al Ozonoff, Grace M Lee
BACKGROUND: Central line-associated bloodstream infections (CLABSIs) cause substantial morbidity and increase antimicrobial use and length of stay among hospitalized children in the United States. CLABSI occurs more frequently among high-risk pediatric patients, such as those with intestinal failure (IF) who are parenteral nutrition (PN) dependent. Following an increase in CLABSI rates, a quality improvement (QI) initiative was implemented. METHODS: Using QI methodology, an enhanced central venous catheter (CVC) maintenance bundle was developed and implemented on 2 units for pediatric PN-dependent patients with IF...
May 16, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29753159/defining-incidence-and-risk-factors-for-catheter-associated-bloodstream-infections-in-an-outpatient-adult-hematopoietic-cell-transplantation-program
#18
Marissa K McDonald, Kathryn A Culos, Katie S Gatwood, Caleb Prow, Heidi Chen, Bipin N Savani, Michael Byrne, Adetola A Kassim, Brian G Engelhardt, Madan Jagasia, Gowri Satyanarayana
Allogeneic hematopoietic cell transplantation (HCT) patients are at an increased risk of developing central line-associated bloodstream infections (CLABSIs) due to prolonged periods of myelosuppression, immunosuppression, and indwelling catheter days. CLABSIs are among the most serious complications in HCT recipients and can lead to prolonged hospitalizations, intensive care unit admissions, lengthy antimicrobial therapies, and increased mortality. There is a lack of data regarding the incidence and risk factors associated with the development of CLABSIs in the HCT population undergoing outpatient transplantation...
May 9, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29730142/implementation-of-tailored-interventions-in-a-statewide-programme-to-reduce-central-line-associated-blood-stream-infections
#19
Denise B Assis, Geraldine Madalosso, Maria Clara Padoveze, Renata D Lobo, Maura S Oliveira, Ícaro Boszczowski, Julio M Singer, Anna S Levin
BACKGROUND: There is a scarcity of studies exploring implementation strategies to central line-associated bloodstream infections (CLABSI) in low or middle income countries. AIM: to implement tailored interventions to reduce CLABSI rates in adult intensive care units (ICU). METHODS: The implementation strategy of the State Health Department was performed in São Paulo State, Brazil over two cycles. Cycle 1 (56 hospitals) was exploratory and Cycle 2 (77 hospitals) was designed to confirm the hypothesis generated by the first cycle, with 3 phases each (pre-intervention, intervention, post-intervention)...
May 3, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29727261/virtual-telemedicine-visits-in-pediatric-home-parenteral-nutrition-patients-a-quality-improvement-initiative
#20
Bram P Raphael, Caitlin Schumann, Sara Garrity-Gentille, Jennifer McClelland, Carolyn Rosa, Christina Tascione, Mary Gallotto, Melissa Takvorian-Bené, Alexandra N Carey, Patrick McCarthy, Christopher Duggan, Al Ozonoff
BACKGROUND: Despite being less costly than prolonged hospitalization, home parenteral nutrition (HPN) is associated with high rates of post-discharge complications, including frequent readmissions and central line-associated bloodstream infections (CLABSIs). Telemedicine has been associated with improved outcomes and reduced healthcare utilization in other high-risk populations, but no studies to date have supported effectiveness of telemedicine in pediatric HPN. METHODS: We prospectively collected data on pediatric patients managed at a single HPN program who participated in postdischarge telemedicine visits from March 1, 2014 to March 30, 2016...
May 4, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
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