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https://www.readbyqxmd.com/read/28629928/safety-and-efficacy-of-endovascular-fiducial-marker-insertion-for-cyberknife-stereotactic-radiation-therapy-planning-in-early-stage-lung-cancer
#1
Mikael Mongeon, Florence Thibault, Carl Chartrand-Lefebvre, Andrei-Bogdan Gorgos, Gilles Soulez, Edith Filion, Eric Therasse
PURPOSE: To evaluate the safety and efficacy of endovascular fiducial markers (EVFMs) for CyberKnife stereotactic radiation therapy (RT) of malignant lung neoplasms in patients with contraindications to percutaneous fiducial marker (PTFM) placement. MATERIALS AND METHODS: Between January 2011 and December 2013, 15 patients (7 men and 8 women) aged 59-87 years (mean, 73 y) underwent EVFM placement and 109 patients (54 men and 55 women) aged 55-92 years (mean, 73 y) underwent 114 PTFM placements...
June 16, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28629461/cost-effectiveness-of-lung-cancer-screening-and-treatment-methods-a-systematic-review-of-systematic-reviews
#2
Farbod Ebadifard Azar, Saber Azami-Aghdash, Fatemeh Pournaghi-Azar, Alireza Mazdaki, Aziz Rezapour, Parvin Ebrahimi, Negar Yousefzadeh
BACKGROUND: Due to extensive literature in the field of lung cancer and their heterogeneous results, the aim of this study was to systematically review of systematic reviews studies which reviewed the cost-effectiveness of various lung cancer screening and treatment methods. METHODS: In this systematic review of systematic reviews study, required data were collected searching the following key words which selected from Mesh: "lung cancer", "lung oncology", "lung Carcinoma", "lung neoplasm", "lung tumors", "cost- effectiveness", "systematic review" and "Meta-analysis"...
June 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28626633/mediastinal-hemangioendothelioma-case-report-and-review-of-the-literature
#3
Davide Patrini, Laura Scolamiero, Reena Khiroya, David Lawrence, Elaine Borg, Martin Hayward, Nikolaos Panagiotopoulos
BACKGROUND: Epithelioid haemangioendothelioma (EHE) is a rare low-grade vascular neoplasm that can arise in the lung, liver, soft tissues or, less commonly, bone. Due to its low prevalence of less than one in a million and its non-specific clinical features, EHE is often misdiagnosed and managed inappropriately. Here we discuss the case of a 58 year-old gentleman with mediastinal EHE and review existing literature on pulmonary EHE (PEH). CASE HISTORY: A 58 year-old gentleman presented to our outpatient Clinic with chest discomfort and palpitations...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28625359/roles-of-arf6-in-cancer-cell-invasion-metastasis-and-proliferation
#4
REVIEW
Rui Li, Cheng Peng, Xianzhe Zhang, Yuewei Wu, Shida Pan, Yechen Xiao
ADP-ribosylation factor 6 (Arf6), a member of small GTPases ADP-ribosylation factor (Arf) family, expresses widely in mammalian cells and mainly regulates the functions of membrane traffic and actin remodeling. Current studies indicated that the activation and high expression of Arf6 protein may be significantly correlated with the invasion and metastasis of several tumors, such as breast cancer, pancreatic cancer, lung cancer, etc. Meanwhile, the ability of tumor invasion and metastasis can be suppressed when Arf6 activity is blocked by the inhibitors or small-interfering RNAs of Arf6...
June 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/28625126/enhanced-risk-for-specific-somatic-myeloproliferative-neoplastic-mutations-in-patients-with-stroke
#5
Chih-Cheng Chen, Chia-Chen Hsu, Cih-En Huang, Yi-Yang Chen, Jrhau Lung, Hsing-Ying Ho, Chian-Pei Li, Jiann-Der Lee
BACKGROUND: Somatic mutations of Janus kinase 2 (JAK2V617F), calreticulin (CALR), and myeloproliferative leukemia virus oncogene (MPL) are the major clonal molecules that drive the pathogenesis of myeloproliferative neoplasms (MPN). It is well recognized that MPN patients carry an excessive risk of thrombohemorrhagic complications. However, little is known about the prevalence of these clonal markers in patients with cerebral vascular disease. METHODS: To address this issue, 153 consecutive stroke patients in Taiwan were enrolled in the study...
June 18, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28617920/milestone-analyses-of-immune-checkpoint-inhibitors-targeted-therapy-and-conventional-therapy-in-metastatic-non-small-cell-lung-cancer-trials-a-meta-analysis
#6
Gideon M Blumenthal, Lijun Zhang, Hui Zhang, Dickran Kazandjian, Sean Khozin, Shenghui Tang, Kirsten Goldberg, Rajeshwari Sridhara, Patricia Keegan, Richard Pazdur
Importance: Novel intermediate end points may be useful to detect signals of early activity and prioritize new therapies to treat patients with advanced malignant neoplasms, including metastatic non-small cell lung cancer (mNSCLC). Objective: To explore milestone rate, a proposed intermediate end point for immunotherapy trials. Data Sources: Trials submitted to the US Food and Drug Administration with more than 150 patients and in which the intention-to-treat population was assessed were identified...
June 15, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28603895/metastatic-neoplasms-to-the-pancreas-diagnosed-by-fine-needle-aspiration-biopsy-cytology-a-15-year-retrospective-analysis
#7
Sasha L T Raymond, Deanne Yugawa, Karen H F Chang, Brandy Ena, Pamela S Tauchi-Nishi
BACKGROUND: Metastatic tumors to the pancreas are rarely encountered and diagnostically challenging. We aspired to determine the incidence and origin of all metastases to the pancreas at our institution, and to examine their clinicopathologic and cytomorphologic features. We also sought to ascertain the effect of endoscopic ultrasound (EUS) guidance implementation. METHODS: A search of our database was undertaken to review all pancreatic FNA and/or CNB examined from January 2000 through December 2014...
June 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28601174/thoracic-neoplasms-in-children-contemporary-perspectives-and-imaging-assessment
#8
REVIEW
Matthew A Zapala, Victor M Ho-Fung, Edward Y Lee
This article focuses on commonly encountered primary lung, airway, mediastinal, and chest wall neoplasms that occur in the pediatric population. Although primary pediatric thoracic neoplasms are rare, imaging is critical in their diagnostic work-up. An overview of the latest imaging techniques specific to evaluate these pediatric thoracic neoplasms is presented across the spectrum of modalities from radiography to PET/MR imaging. In addition, the characteristic imaging appearances of these pediatric primary thoracic neoplasms are discussed with an emphasis on what the radiologist needs to know in routine clinical practice...
July 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28597001/calcified-liver-metastases-from-a-neuroendocrine-tumor-of-the-lung-atypical-carcinoid-a-case-report
#9
Rolf Reiter, Jochen Maul, Jan Christian Preis, Hendrik Blaeker, Zarko Grozdanovic
Pulmonary neuroendocrine tumors (NETs) are rare tumors with an incidence rate of 0.2-2/100 000 population/year in Western countries (M. E. Caplin et al. Ann Oncol 2015; 26:1604-20). They account for 1-2% of all neoplasms of the lung and constitute one-fourth to one-third of all NETs. Atypical carcinoids are far less common than typical carcinoids and predominantly occur in male smokers aged 50 -70 years. Most pulmonary NETs are asymptomatic due to their peripheral location. Surgical resection is the treatment of choice...
April 2017: Ultrasound International Open
https://www.readbyqxmd.com/read/28596924/an-unusual-case-of-pancreatic-metastasis-from-squamous-cell-carcinoma-of-the-lung-diagnosed-by-eus-guided-fine-needle-biopsy
#10
Takuya Ishikawa, Yoshiki Hirooka, Carolin J Teman, Hidemi Goto, Paul J Belletrutti
We report a case of a 70-year-old man who presented with abdominal pain and weight loss, with initial imaging showing simultaneous mass lesions in the pancreas and lungs along with extensive lymphadenopathy in the thorax up to the left supraclavicular region. Core biopsies of the left supraclavicular lymph node showed squamous cell carcinoma, which required differentiation between secondary and primary pancreatic neoplasms. Endoscopic ultrasound-guided sampling using a novel fine needle biopsy system was key to making a definite histological diagnosis and determining the best treatment plan...
2017: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/28588778/rexin-g-%C3%A2-a-tumor-targeted-retrovector-for-malignant-peripheral-nerve-sheath-tumor-a-case-report
#11
Seth Kim, Noah Federman, Erlinda M Gordon, Frederick L Hall, Sant P Chawla
Soft tissue sarcoma is a rare neoplasm of mesenchymal origin, accounting for only ~1% of all adult cancers and consisting of 75 histological subtypes. In the present report, the unique case of a 14 year-old female with metastatic malignant peripheral nerve sheath tumor (formerly, malignant melanotic schwannoma) of the parotid gland, who experienced a durable response and sustained tumor control with Rexin-G(®), a tumor-targeted retroviral expression vector encoding an anti-cyclin G1 construct, is described...
June 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28578631/surfactant-protein-a-and-napsin-a-in-the-immunohistochemical-characterization-of-canine-pulmonary-carcinomas-comparison-with-thyroid-transcription-factor-1
#12
Jessica Beck, Margaret A Miller, Chad Frank, Dee DuSold, José Antonio Ramos-Vara
Thyroid transcription factor-1 (TTF-1) is a specific and sensitive marker for canine pulmonary tumors but is also expressed in thyroid carcinomas, which commonly metastasize to lung. Napsin A and surfactant protein A (SP-A) are used in the histologic diagnosis of non-small-cell lung cancer in humans but have not been thoroughly evaluated in neoplasms of dogs. The objective of this study was to compare the efficacy of immunohistochemistry for SP-A, napsin A, and TTF-1 in the diagnosis of canine pulmonary carcinomas...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28574869/cancer-incidence-estimation-method-an-apulian-experience
#13
Anna M Nannavecchia, Ivan Rashid, Francesco Cuccaro, Antonio Chieti, Danila Bruno, Maria G Burgio Lo Monaco, Cinzia Tanzarella, Lucia Bisceglia
The Cancer Registry of Puglia (RTP) was instituted in 2008 as a regional population-based cancer registry. It consists of six sections (Foggia, Barletta-Andria-Tran, Bari, Brindisi, Lecce, and Taranto) and covers more than 4 000 000 inhabitants. At present, four of six sections have received accreditation by AIRTUM (53% of regional population). To point out possible regional geographic variability in cancer incidence and also to support health services planning, we developed an original estimation method to ensure a complete territorial coverage...
June 1, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28573444/lung-lesions-during-fever-of-unknown-origin
#14
Renata Krupa, Tadeusz M Zielonka, Malgorzata Hadzik-Blaszczyk, Kazimierz A Wardyn, Katarzyna Zycinska
Fever of unknown origin (FUO) remains one of the most difficult diagnostic challenges. The causes of FUO can be various diseases located in different organs. The aim of the study was to determine the prevalence and nature of pulmonary lesions during FUO. One hundred and sixty one patients with FUO participated in this prospective study. We performed a detailed comprehensive history, physical examination, and a wide spectrum of tests. The most common causes of FUO were infections (39%), autoimmune conditions (28%), and neoplasms (17%)...
June 2, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28571584/spotlight-on-landmark-oncology-trials-the-latest-evidence-and-novel-trial-designs
#15
EDITORIAL
Helena Earl, Stefano Molica, Piotr Rutkowski
The era of precision oncology is marked with prominent successes in the therapy of advanced soft tissue sarcomas, breast cancer, ovarian cancer and haematological neoplasms, among others. Moreover, recent trials of immune checkpoint inhibitors in melanoma, non-small cell lung carcinoma, and head and neck cancers have significantly influenced the therapeutic landscape by providing promising evidence for immunotherapy efficacy in the adjuvant setting in high-risk locoregional disease. To speed up the introduction of targeted therapy for cancer patients, novel phase II trials are being designed, and may likely form the basis for the 'landmark trials' of the future...
June 2, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28567329/carcinosarcoma-of-the-tunica-vaginalis-following-radiation-therapy-for-localized-prostate-cancer
#16
Charles D Viers, Subodh M Lele, Tara Kirkpatrick, Chad A LaGrange
Spermatic cord tumors (SCTs) are rare neoplasms with 80% exhibiting benign pathology. Of the malignant SCTs, 90% are sarcomas. To date there has only been one documented case of primary CS of the spermatic cord which occurred in a 40 year old with no reported medical history. A 76-year-old male with a history of biopsy proven Gleason score 7 (3 + 4) prostatic adenocarcinoma underwent external beam radiation therapy (7920 cGy) in 44 fractions in 2004. He presented with a 3 year history of an asymptomatic right hydrocele...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28559704/endobronchial-ultrasound-one-year-of-experience-in-clinical-practice
#17
Marioara Simon, Bogdan Pop, Lacramioara Toma, Aletta Vallasek, Ioan Simon
BACKGROUND AND AIM: Endobronchial ultrasound (EBUS) is a recent minimally invasive, safe examination method for the mediastinum, with a good diagnostic precision. This method makes possible real time examination with transbronchial fine needle aspiration, diagnostic transbronchial needle aspiration (TBNA) and staging of non-small pulmonary tumors, as well as diagnosis of mediastinal and hilar adenopathies of various causes. METHODS: We present the experience of the Bronchoscopy Department of the Pulmonology Clinic of Cluj-Napoca with EBUS-TBNA as a tool for the diagnosis and staging of tumors in contact with the bronchial wall and mediastinal and hilar adenopathies of unknown etiology...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/28555346/endobronchial-metastasis-from-extrapulmonary-neoplasms-analysis-of-clinicopathologic-features-and-cytological-evaluation-by-bronchial-brushing
#18
Kenji Ikemura, Diana Murro Lin, Colin P Martyn, Ji-Weon Park, Christopher W Seder, Paolo Gattuso
PURPOSE: Bronchial brushings (BB) commonly aid in the diagnosis of primary lung cancer. However, the utility of this method in diagnosing endobronchial metastases (EBM) from extrapulmonic malignancies has not been thoroughly evaluated. The purpose of this study is to evaluate the sensitivity of BB in diagnosing EBM. METHODS: An institutional database was queried for all patients with cytologically or histologically confirmed extrapulmonary EBM identified by endobronchial biopsy between 1978 and 2013...
May 29, 2017: Lung
https://www.readbyqxmd.com/read/28555282/smarca4-deficient-pulmonary-adenocarcinoma-clinicopathological-immunohistochemical-and-molecular-characteristics-of-a-novel-aggressive-neoplasm-with-a-consistent-ttf1-neg-ck7-pos-heppar-1-pos-immunophenotype
#19
Abbas Agaimy, Florian Fuchs, Evgeny A Moskalev, Horia Sirbu, Arndt Hartmann, Florian Haller
Alterations in SMARCA4, a member of the chromatin remodeling Switch Sucrose Non-Fermentable (SWI/SNF) complex, characterize a subset of non-small cell lung cancer (NSCLC), but detailed morphological and immunophenotypic description of this tumor type is lacking. We describe 20 NSCLC cases found on routine screening not to express SMARCA4 by immunohistochemistry (IHC). These tumors were stained for CK7, TTF1, SMARCA2, SMARCA4, SMARCB1, and HepPar-1 and analyzed for molecular alterations, using a 160 cancer-related gene panel including the full coding sequence of SMARCA4...
May 30, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28553668/the-clinical-spectrum-of-erdheim-chester-disease-an-observational-cohort-study
#20
Juvianee I Estrada-Veras, Kevin J O'Brien, Louisa C Boyd, Rahul H Dave, Benjamin Durham, Liqiang Xi, Ashkan A Malayeri, Marcus Y Chen, Pamela J Gardner, Jhonell R Alvarado-Enriquez, Nikeith Shah, Omar Abdel-Wahab, Bernadette R Gochuico, Mark Raffeld, Elaine S Jaffe, William A Gahl
Erdheim-Chester Disease (ECD) is a rare, potentially fatal, multi-organ myeloid neoplasm occurring mainly in adults. The diagnosis is established by clinical, radiologic, and histologic findings; ECD tumors contain foamy macrophages that are CD68+, CD163+, CD1a-, and frequently S100-. The purpose of this report is to describe the clinical and molecular variability of ECD. Sixty consecutive ECD patients (45 males, 15 females) were prospectively evaluated at the NIH Clinical Center between 2011 and 2015. Comprehensive imaging and laboratory studies were performed, and tissues were examined for BRAF V600E and MAPK pathway mutations...
February 14, 2017: Blood Advances
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