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https://www.readbyqxmd.com/read/29625564/urinary-proteomics-for-prediction-of-mortality-in-patients-with-type-2-diabetes-and-microalbuminuria
#1
Gemma E Currie, Bernt Johan von Scholten, Sheon Mary, Jose-Luis Flores Guerrero, Morten Lindhardt, Henrik Reinhard, Peter K Jacobsen, William Mullen, Hans-Henrik Parving, Harald Mischak, Peter Rossing, Christian Delles
BACKGROUND: The urinary proteomic classifier CKD273 has shown promise for prediction of progressive diabetic nephropathy (DN). Whether it is also a determinant of mortality and cardiovascular disease in patients with microalbuminuria (MA) is unknown. METHODS: Urine samples were obtained from 155 patients with type 2 diabetes and confirmed microalbuminuria. Proteomic analysis was undertaken using capillary electrophoresis coupled to mass spectrometry to determine the CKD273 classifier score...
April 6, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29615702/global-proteomics-deciphered-novel-function-of-osthole-against-pulmonary-arterial-hypertension
#2
Li Yao, Yuxia Yang, Guanhong He, Chunqing Ou, Lan Wang, Kaixuan Liu
Pulmonary arterial hypertension (PAH) is a progressive cardiovascular-disease with high mortality lacking high-efficiency drug. Our efforts attempted to delineate therapeutic action of osthole produced by Angelica Pubescens Maxim, which has the capacity to treat PAH by exploiting an iTRAQ-based proteomic method. Excitingly, osthole was observed to significantly restore 98 of 315 differential proteins significantly modified by PAH progression. They were primarily annotated into 24 signaling pathways. Four mostly affected proteins (RPL15, Cathepsin S, Histone H3...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29615349/assessment-of-extracellular-matrix-related-biomarkers-in-patients-with-lower-extremity-artery-disease
#3
Anna Hernández-Aguilera, Signe Holm Nielsen, Cristina Bonache, Salvador Fernández-Arroyo, Vicente Martín-Paredero, Montserrat Fibla, Morten A Karsdal, Federica Genovese, Javier A Menendez, Jordi Camps, Jorge Joven
BACKGROUND: The prevalence of lower extremity artery disease (LEAD) is high (20%-25%) in the population older than 65 years, but patients are seldom identified until the disease is advanced. Circulating markers of disease activity might provide patients with a key opportunity for timely treatment. We tested the hypothesis that measuring blood-specific fragments generated during degradation of the extracellular matrix (ECM) could provide further insight into the pathophysiologic mechanism of arterial remodeling...
March 31, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29611167/proteomics-study-of-serum-exosomes-in-kawasaki-disease-patients-with-coronary-artery-aneurysms
#4
Xiao-Fei Xie, Hong-Juan Chu, Yu-Fen Xu, Liang Hua, Zhou-Ping Wang, Ping Huang, Hong-Ling Jia, Li Zhang
BACKGROUND: To study the protein profile of the serum exosomes of patients with coronary artery aneurysms (CAA) caused by Kawasaki disease (KD). METHODS: Two-dimensional electrophoresis (2-DE) was used to identify proteins from the exosomes of serum obtained from children with CAA caused by KD, as well as healthy controls. Differentially expressed proteins were identified using matrix-assisted laser desorption/ionization time-of-flight/time-of-flight mass spectrometry (MALDI-TOF/TOF MS) analysis...
April 3, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29554300/challenges-and-opportunities-in-stroke-genetics
#5
Rainer Malik, Martin Dichgans
Stroke, ischemic stroke and subtypes of ischemic stroke display substantial heritability. Compared to related vascular conditions, the number of established risk loci reaching genome-wide significance for association with stroke is still in the lower range, particularly for etiological stroke subtypes such as large artery atherosclerotic stroke or small vessel stroke. Nevertheless, for individual loci substantial progress has been made in determining the specific mechanisms mediating stroke risk. In this review, we present a roadmap for functional follow-up of common risk variants associated with stroke...
March 15, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29549767/influence-of-dynamic-flow-conditions-on-adsorbed-plasma-protein-corona-and-surface-induced-thrombus-generation-on-antifouling-brushes
#6
Kai Yu, Paula Andruschak, Han Hung Yeh, Dana Grecov, Jayachandran N Kizhakkedathu
The information regarding the nature of protein corona (and its changes) and cell binding on biomaterial surface under dynamic conditions is critical to dissect the mechanism of surface-induced thrombosis. In this manuscript, we investigated the nature of protein corona and blood cell binding in heparinized recalcified human plasma, platelet rich plasma and whole blood on three highly hydrophilic antifouling polymer brushes, (poly(N, N-dimethylacrylamide) (PDMA), poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) and poly[N-(2-hydroxypropyl) methacrylamide] (PHPMA) using an in vitro blood loop model at comparable arterial and venous flow, and static conditions...
March 8, 2018: Biomaterials
https://www.readbyqxmd.com/read/29540307/oxidative-cross-linking-of-proteins-to-dna-following-ischemia-reperfusion-injury
#7
Arnold Groehler, Stefan Kren, Qinglu Li, Maggie Robledo-Villafane, Joshua Schmidt, Mary Garry, Natalia Tretyakova
Myocardial infarction (MI) is a life-threatening condition that can occur when blood flow to the heart is interrupted due to a blockage in one or more of the coronary vessels. Current treatments of MI rapidly restore blood flow to the affected myocardium using thrombolytic agents or angioplasty. Adverse effects including inflammation, tissue necrosis, and ventricular dysfunction are, however, not uncommon following reperfusion therapy. These conditions are thought to be caused by a sudden influx of reactive oxygen species (ROS) to the affected myocardium...
March 11, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29538004/identification-of-haptoglobin-as-a-potential-diagnostic-biomarker-of-acute-pulmonary-embolism
#8
Yun-Xia Zhang, Ji-Feng Li, Yuan-Hua Yang, Ke Huang, Ran Miao, Zhen-Guo Zhai, Chen Wang
: Acute pulmonary embolism is a common disease, which is associated with high mortality and morbidity. There is significant relationship between haptoglobin and pulmonary embolism, however, the usefulness of haptoglobin as a biomarker for the diagnosis of pulmonary embolism remains poorly defined. The aim of the present study was to investigate the change and clinical diagnostic value of haptoglobin in pulmonary embolism. A comparative proteomic analysis was used for clinical screening of serum proteins in 18 patients (9 patients with pulmonary embolism and 9 controls)...
March 13, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29518183/cardioprotection-by-cardiac-progenitor-cell-secreted-exosomes-role-of-pregnancy-associated-plasma-protein-a
#9
Lucio Barile, Elisabetta Cervio, Vincenzo Lionetti, Giuseppina Milano, Alessandra Ciullo, Vanessa Biemmi, Sara Bolis, Claudia Altomare, Marco Matteucci, Dario Disilvestre, Tudor Emanuel Fertig, Tiziano Torre, Stefanos Demertzis, Pierluigi Mauri, Tiziano Moccetti, Giuseppe Vassalli
Aims: Cell therapy trials using cardiac-resident progenitor cells (CPCs) and bone marrow-derived mesenchymal stem/progenitor cells (BMCs) in patients after myocardial infarction have provided encouraging results. Exosomes, nanosized extracellular vesicles of endosomal origin, figure prominently in the bioactivities of these cells. However, a head-to-head comparison of exosomes from the two cell types has not been performed yet. Methods and Results: CPCs and BMCs were derived from cardiac atrial appendage specimens and sternal bone marrow, respectively, from patients (n=20; age, 69...
March 5, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29511131/endothelial-progenitor-cell-secretome-and-oligovascular-repair-in-a-mouse-model-of-prolonged-cerebral-hypoperfusion
#10
Takakuni Maki, Anna Morancho, Pablo Martinez-San Segundo, Kazuhide Hayakawa, Hajime Takase, Anna C Liang, Marina Gabriel-Salazar, Esperanza Medina-Gutiérrez, Kazuo Washida, Joan Montaner, Josephine Lok, Eng H Lo, Ken Arai, Anna Rosell
BACKGROUND AND PURPOSE: Endothelial progenitor cells (EPCs) have been extensively investigated as a therapeutic approach for repairing the vascular system in cerebrovascular diseases. Beyond vascular regeneration per se, EPCs may also release factors that affect the entire neurovascular unit. Here, we aim to study the effects of the EPC secretome on oligovascular remodeling in a mouse model of white matter injury after prolonged cerebral hypoperfusion. METHODS: The secretome of mouse EPCs was analyzed with a proteome array...
March 6, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29508616/proteomic-identification-of-interferon-induced-proteins-with-tetratricopeptide-repeats-ifits-as-markers-of-m1-macrophage-polarization
#11
Cheng Huang, Caitlin Lewis, Natalie A Borg, Meritxell Canals, Henry Diep, Grant Drummond, Robert J Goode, Ralf B Schittenhelm, Antony Vinh, Mingyu Zhu, Barbara Kemp-Harper, Oded Kleifeld, Martin J Stone
Macrophages, which accumulate in tissues during inflammation, may be polarized towards pro-inflammatory (M1) or tissue reparative (M2) phenotypes. The balance between these phenotypes can have a substantial influence on the outcome of inflammatory diseases such as atherosclerosis. Improved biomarkers of M1 and M2 macrophages would be beneficial for research, diagnosis and monitoring the effects of trial therapeutics in such diseases. To identify novel biomarkers, we have characterized the global proteomes of THP-1 macrophages polarized to M1 and M2 states, in comparison with unpolarized (M0) macrophages...
March 6, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29505607/myeloperoxidase-mediated-hdl-oxidation-and-hdl-proteome-changes-do-not-contribute-to-dysfunctional-hdl-in-chinese-subjects-with-coronary-artery-disease
#12
Guisong Wang, Anna Vachaparampil Mathew, Haiyi Yu, Lei Li, Liyun He, Wei Gao, Xiaodan Liu, Yanhong Guo, Jaeman Byun, Jifeng Zhang, Y Eugene Chen, Subramaniam Pennathur
High density lipoprotein (HDL) cholesterol levels and cholesterol efflux capacity (CEC) are inversely correlated with coronary artery disease (CAD) risk. Myeloperoxidase (MPO) derived oxidants and HDL proteome changes are implicated in HDL dysfunction in subjects with CAD in the United States; however, the effect of MPO on HDL function and HDL proteome in ethnic Chinese population is unknown. We recruited four matched ethnic Chinese groups (20 patients each): subjects with 1) low HDL levels (HDL levels in men <40mg/dL and women <50mg/dL) and non-CAD (identified by coronary angiography or cardiac CT angiography); 2) low HDL and CAD; 3) high HDL (men >50mg/dL; women >60mg/dL) with no CAD; and 4) high HDL with CAD...
2018: PloS One
https://www.readbyqxmd.com/read/29487139/proteomic-biomarkers-for-incident-aortic-stenosis-requiring-valvular-replacement
#13
Johan Ljungberg, Mikael Janiec, Ingvar A Bergdahl, Anders Holmgren, Johan Hultdin, Bengt Johansson, Ulf Näslund, Agneta Siegbahn, Tove Fall, Stefan Söderberg
Background -Aortic valve stenosis (AS) is the most common indication for cardiac valve surgery; untreated AS is linked to high mortality. The aetiological background of AS is unknown. Previous human studies were typically based on case-control studies. Biomarkers identified in prospective studies could lead to novel mechanistic insights. Methods -Within a large population survey with blood samples obtained at baseline, 334 patients were identified that later underwent surgery for AS (median age (interquartile range) 59...
February 27, 2018: Circulation
https://www.readbyqxmd.com/read/29470511/preliminary-analysis-of-proteome-alterations-in-non-aneurysmal-internal-mammary-artery-tissue-from-patients-with-abdominal-aortic-aneurysms
#14
Christina Lund Kidholm, Hans Christian Beck, Julie Bukh Madsen, Nikolai Bjødstrup Palstrøm, Jes Sanddal Lindholt, Lars Melholt Rasmussen
OBJECTIVE: The pathogenesis of abdominal aortic aneurysms (AAA) involves a disturbed balance of breakdown and buildup of arterial proteins. We envision that individuals with AAA carry generalized arterial protein alterations either because of effects of genetically or environmental AAA risk factors or because of compensatory changes due to signaling molecules released from the affected aneurysmal tissue. APPROACH: Protein extraction and quantitative proteome analysis by LC-MS/MS (liquid chromatography-mass spectrometry) was done on individual samples from the internal mammary artery from 11 individuals with AAA and 33 sex- and age-matched controls without AAA...
2018: PloS One
https://www.readbyqxmd.com/read/29439246/cyclic-mechanical-stretch-induced-smooth-muscle-cell-changes-in-cerebral-aneurysm-progress-by-reducing-collagen-type-iv-and-collagen-type-vi-levels
#15
Peixi Liu, Yaying Song, Yingjie Zhou, Yingjun Liu, Tianming Qiu, Qingzhu An, Jianping Song, Peiliang Li, Yuan Shi, Sichen Li, Kai Quan, Guo-Yuan Yang, Wei Zhu
BACKGROUND/AIMS: Cerebral aneurysm growth is characterized by continuous structural weakness of local smooth muscle cells, though the mechanism is unclear. In this study, we examine protein changes in cerebral aneurysm and human brain vascular smooth muscle cells after cyclic mechanical stretch. We further explore the relationship between the smooth muscle cell changes and reductions in the levels of collagen types IV and VI. METHODS: Saccular cerebral aneurysms (n=10) were collected, and temporal artery samples were used as controls...
February 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29426953/cerebral-ischemia-induces-the-aggregation-of-proteins-linked-to-neurodegenerative-diseases
#16
Anja Kahl, Ismary Blanco, Katherine Jackman, Juhi Baskar, Harihar Milaganur Mohan, Reunet Rodney-Sandy, Sheng Zhang, Costantino Iadecola, Karin Hochrainer
Protein aggregation critically affects cell viability in neurodegenerative diseases, but whether this also occurs in ischemic brain injury remains elusive. Prior studies report the post-ischemic aggregation of ubiquitin, small ubiquitin-related modifier (SUMO) and ribosomes, however whether other proteins are also affected is unknown. Here we employed a proteomic approach to identify the insoluble, aggregated proteome after cerebral ischemia. Mice underwent transient middle cerebral artery occlusion or sham-surgery...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29416745/itraq-analysis-of-a-mouse-acute-myocardial-infarction-model-reveals-that-vitamin-d-binding-protein-promotes-cardiomyocyte-apoptosis-after-hypoxia
#17
Yun Wu, Fen Liu, Xiang Ma, Dilare Adi, Ming-Tao Gai, Xiang Jin, Yi-Ning Yang, Ying Huang, Xiang Xie, Xiao-Mei Li, Zhen-Yan Fu, Bang-Dang Chen, Yi-Tong Ma
The proteome profile changes after acute myocardial infarction (AMI) and the roles played by important protein species remain poorly understood. Here, we constructed a mouse AMI model by ligating the left coronary artery of male C57B/6J mice to investigate the molecular changes after AMI on the protein level. Total proteins of the left ventricle were extracted and quantitatively analyzed by isobaric tags using relative and absolute quantitation (iTRAQ) technologies. The transcript and protein levels of important genes were further validated using quantitative polymerase chain reaction and western blot...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29399028/quercetin-attenuates-the-injury-induced-reduction-of-%C3%AE-enolase-expression-in-a-middle-cerebral-artery-occlusion-animal-model
#18
Seong-Jun Jeon, Myeong-Ok Kim, Fawad Ali-Shah, Phil-Ok Koh
Quercetin, a natural flavonoid, copiously exists in vegetable, fruits and tea. Quercetin is beneficial to neurodegenerative disorders via its strong anti-oxidant and anti-inflammatory activities. γ-Enolase is one of the enzymes of glycolytic pathway and is predominantly expressed in neuronal cells. The aim of the present study is to verify whether quercetin modulates the expression of γ-enolase in brain ischemic injury. Adult Sprague-Dawley male rats were subjected to middle cerebral artery occlusion (MCAO) and quercetin (50 mg/kg) or vehicle was administered by intraperitoneal injection at 1 h before MCAO onset...
December 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29395098/distinctive-molecular-signature-and-activated-signaling-pathways-in-aortic-smooth-muscle-cells-of-patients-with-myocardial-infarction
#19
Thidathip Wongsurawat, Chin Cheng Woo, Antonis Giannakakis, Xiao Yun Lin, Esther Sok Hwee Cheow, Chuen Neng Lee, Mark Richards, Siu Kwan Sze, Intawat Nookaew, Vladimir A Kuznetsov, Vitaly Sorokin
BACKGROUND AND AIMS: We aim to identify significant transcriptome alterations of vascular smooth muscle cells (VSMCs) in the aortic wall of myocardial infarction (MI) patients. Providing a robust transcriptomic signature, we aim to highlight the most likely aberrant pathway(s) in MI VSMCs. METHODS AND RESULTS: Laser-captured microdissection (LCM) was used to obtain VSMCs from aortic wall tissues harvested during coronary artery bypass surgery. Microarray gene analysis was applied to analyse VSMCs from 17 MI and 19 non-MI patients...
January 29, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29378352/atherothrombosis-and-thromboembolism-position-paper-from-the-second-maastricht-consensus-conference-on-thrombosis
#20
H M H Spronk, T Padro, J E Siland, J H Prochaska, J Winters, A C van der Wal, J J Posthuma, G Lowe, E d'Alessandro, P Wenzel, D M Coenen, P H Reitsma, W Ruf, R H van Gorp, R R Koenen, T Vajen, N A Alshaikh, A S Wolberg, F L Macrae, N Asquith, J Heemskerk, A Heinzmann, M Moorlag, N Mackman, P van der Meijden, J C M Meijers, M Heestermans, T Renné, S Dólleman, W Chayouâ, R A S Ariëns, C C Baaten, M Nagy, A Kuliopulos, J J Posma, P Harrison, M J Vries, H J G M Crijns, E A M P Dudink, H R Buller, Y M C Henskens, A Själander, S Zwaveling, O Erküner, J W Eikelboom, A Gulpen, F E C M Peeters, J Douxfils, R H Olie, T Baglin, A Leader, U Schotten, B Scaf, H M M van Beusekom, L O Mosnier, L van der Vorm, P Declerck, M Visser, D W J Dippel, V J Strijbis, K Pertiwi, A J Ten Cate-Hoek, H Ten Cate
Atherothrombosis is a leading cause of cardiovascular mortality and long-term morbidity. Platelets and coagulation proteases, interacting with circulating cells and in different vascular beds, modify several complex pathologies including atherosclerosis. In the second Maastricht Consensus Conference on Thrombosis, this theme was addressed by diverse scientists from bench to bedside. All presentations were discussed with audience members and the results of these discussions were incorporated in the final document that presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following five topics: 1...
February 2018: Thrombosis and Haemostasis
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