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https://www.readbyqxmd.com/read/28221956/microbiological-quality-and-occurrence-of-nontuberculous-mycobacteria-in-fresh-squeezed-orange-juice-samples-purchased-from-street-vendors-in-mexico-city
#1
Jorge F Cerna-Cortes, Ana Laura Cortes-Cueto, Maria Rosalia Cano-Gaona, Nancy Leon-Montes, Addy C Helguera-Repetto, Sandra Rivera-Gutierrez, Laura P Salas-Rangel, Javier Castro-Rosas, Jorge A Gonzalez-Y-Merchand
Nontuberculous mycobacteria (NTM) are potentially pathogenic agents commonly found in a natural ecosystem. For this reason, food is considered another source of NTM transmission for humans. The aims of this study were to evaluate the microbiological quality and the occurrence of NTM in fresh-squeezed orange juice samples purchased from street vendors. All 102 samples analyzed were positive for aerobic mesophilic bacteria (AMB), with limits ranging from 1.8 to 6.2 log CFU/ml. A total of 55 (54%), 25 (25%), and 13 (13%) orange juice samples were positive for total coliforms (TC), fecal coliforms (FC), and Escherichia coli , respectively...
December 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221903/prevalence-and-level-of-listeria-monocytogenes-in-ice-cream-linked-to-a-listeriosis-outbreak-in-the-united-states
#2
Y I Chen, Laurel S Burall, Dumitru Macarisin, Régis Pouillot, Errol Strain, Antonio J DE Jesus, Anna Laasri, Hua Wang, Laila Ali, Aparna Tatavarthy, Guodong Zhang, Lijun Hu, James Day, Jihun Kang, Surasri Sahu, Devayani Srinivasan, Karl Klontz, Mickey Parish, Peter S Evans, Eric W Brown, Thomas S Hammack, Donald L Zink, Atin R Datta
A most-probable-number (MPN) method was used to enumerate Listeria monocytogenes in 2,320 commercial ice cream scoops manufactured on a production line that was implicated in a 2015 listeriosis outbreak in the United States. The analyzed samples were collected from seven lots produced in November 2014, December 2014, January 2015, and March 2015. L. monocytogenes was detected in 99% (2,307 of 2,320) of the tested samples (lower limit of detection, 0.03 MPN/g), 92% of which were contaminated at <20 MPN/g...
November 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221884/neural-network-model-for-thermal-inactivation-of-salmonella-typhimurium-to-elimination-in-ground-chicken-acquisition-of-data-by-whole-sample-enrichment-miniature-most-probable-number-method
#3
T P Oscar
Predictive models are valuable tools for assessing food safety. Existing thermal inactivation models for Salmonella and ground chicken do not provide predictions above 71°C, which is below the recommended final cooked temperature of 73.9°C for chicken. They also do not predict when all Salmonella are eliminated without extrapolating beyond the data used to develop them. Thus, a study was undertaken to develop a model for thermal inactivation of Salmonella to elimination in ground chicken at temperatures above those of existing models...
January 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28218607/tet2-asxl1-idh1-and-idh2-single-nucleotide-polymorphisms-in-turkish-patients-with-chronic-myeloproliferative-neoplasms
#4
Nur Soyer, Burçin Tezcanlı Kaymaz, Melda Cömert Özkan, Çağdaş Aktan, Ali Şahin Küçükaslan, Fahri Şahin, Buket Kosova, Güray Saydam
We aimed to determine the genotype distribution, allele frequency and prognostic impact of IDH1/2(Isocitrate dehydrogenase), TET2(Ten-Eleven-Translocation2) and ASXL1(Additional Sex Combs-Like 1) single nucleotide polymorphisms (SNPs) in MPNs. TET2(rs763480), ASXL1(rs2208131) and IDH1(rs11554137) variant homozygous genotype frequencies were 1.5%, 9.2% and 2.3%, respectively. No IDH2 SNP was identified. IDH1 and TET2 frequencies were 5% in ET and 1.7% in ET, 5% in PMF, respectively. ASXL1 frequencies were 8...
February 20, 2017: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/28211153/the-prognostic-relevance-of-serum-lactate-dehydrogenase-and-mild-bone-marrow-reticulin-fibrosis-in-essential-thrombocythemia
#5
Mythri Mudireddy, Daniela Barraco, Curtis A Hanson, Animesh Pardanani, Naseema Gangat, Ayalew Tefferi
The 2016 World Health Organization (WHO) diagnostic criteria for myeloproliferative neoplasms (MPN) underscore the prognostically-relevant distinction between essential thrombocythemia (ET) and prefibrotic primary myelofibrosis (pre-PMF). In addition, leukocytosis has been identified as an important prognostic marker in otherwise WHO-defined ET. However, controversy remains regarding the objectivity of morphologic criteria in distinguishing ET from pre-PMF and the precise prognostic cutoff values for leukocytosis...
February 17, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28210459/microbiological-qualification-of-air-water-and-dialysate-in-a-haemodialysis-centre-a-new-focus-on-legionella-spp
#6
Saeid Nazemi, Mehdi Mirzaii, Somayeh Yaslianifard, Davood Darban-Sarokhalil, Seyyed Sajjad Khoramrooz, Pirasteh Norozi, Fatemeh Davardoost
BACKGROUND AND OBJECTIVES: The microbiological monitoring of the water used for haemodialysis is important especially for Legionella and non-fermentative bacteria since patients with end stage renal disease (ESRD) are suffering from deteriorated function of immune system. MATERIALS AND METHODS: A total 50 water and dialysate samples were weekly collected over a period of 10 weeks from 5 sites. Total and faecal coliforms were determined by utilizing the most probable number (MPN) method...
August 2016: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/28207311/prevalence-of-salmonella-in-cashews-hazelnuts-macadamia-nuts-pecans-pine-nuts-and-walnuts-in-the-united-states
#7
Guodong Zhang, Lijun Hu, David Melka, Hua Wang, Anna Laasri, Eric W Brown, Errol Strain, Marc Allard, Vincent K Bunning, Steven M Musser, Rhoma Johnson, Sofia M Santillana Farakos, Virginia N Scott, Régis Pouillot, Jane M Van Doren, Thomas S Hammack
Nuts have been identified as a vector for salmonellosis. The objective of this project was to estimate the prevalence and contamination level of Salmonella in raw tree nuts (cashews, pecans, hazelnuts, macadamia nuts, pine nuts, and walnuts) at retail markets in the United States. A total of 3,656 samples of six types of tree nuts were collected from different types of retail stores and markets nationwide between October 2014 and October 2015. These samples were analyzed using a modified version of the Salmonella culture method from the U...
February 16, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28202867/gm-csf-autoantibody-positive-pulmonary-alveolar-proteinosis-with-simultaneous-myeloproliferative-neoplasm
#8
Naoto Imoto, Nakashima Harunori, Katsuya Furukawa, Naoyuki Tange, Atsushi Murase, Masaya Hayakawa, Masatoshi Ichihara, Yosuke Iwata, Hiroshi Kosugi
Pulmonary alveolar proteinosis (PAP) is classified as autoimmune, secondary, or genetic. We herein describe a 69-year-old man with autoimmune PAP, simultaneously diagnosed with myeloproliferative neoplasm (MPN). Two years after the diagnosis, the MPN progressed to acute myeloid leukemia, and the patient died from an alveolar hemorrhage during remission induction chemotherapy. Throughout the clinical course, no progression of PAP was observed, despite the progression to leukemia. There are few reports of autoimmune PAP with hematological malignancy, and this case demonstrated that an evaluation for GM-CSF autoantibodies is important for distinguishing the autoimmune and secondary forms of PAP, even if the patient has hematological malignancy...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28197147/spoilage-of-microfiltered-and-pasteurized-extended-shelf-life-milk-is-mainly-induced-by-psychrotolerant-spore-forming-bacteria-that-often-originate-from-recontamination
#9
Etienne V Doll, Siegfried Scherer, Mareike Wenning
Premature spoilage and varying product quality due to microbial contamination still constitute major problems in the production of microfiltered and pasteurized extended shelf life (ESL) milk. Spoilage-associated bacteria may enter the product either as part of the raw milk microbiota or as recontaminants in the dairy plant. To identify spoilage-inducing bacteria and their routes of entry, we analyzed end products for their predominant microbiota as well as the prevalence and biodiversity of psychrotolerant spores in bulk tank milk...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28188970/refractory-anemia-with-ring-sideroblasts-rars-and-rars-with-thrombocytosis-rars-t-2017-update-on-diagnosis-risk-stratification-and-management
#10
Mrinal M Patnaik, Ayalew Tefferi
DISEASE OVERVIEW: Ring sideroblasts (RS) are erythroid precursors with abnormal perinuclear mitochondrial iron accumulation. Two myeloid neoplasms defined by the presence of RS, include refractory anemia with ring sideroblasts (RARS), now classified under myelodysplastic syndromes with RS (MDS-RS) and RARS with thrombocytosis (RARS-T); now called myelodysplastic/myeloproliferative neoplasm with RS and thrombocytosis (MDS/MPN-RS-T). DIAGNOSIS: MDS-RS is a lower risk MDS, with single or multilineage dysplasia (SLD/MLD), <5% bone marrow (BM) blasts and ≥15% BM RS (≥5% in the presence of SF3B1 mutations)...
March 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28186604/-clinical-and-genetic-features-of-a-patient-with-myeloid-neoplasm-in-association-with-pdgfra-and-evi1-gene-rearrangements
#11
Wenmin Han, Hongying Chao, Min Zhou, Ling Cen, Suning Chen, Xuefeng He, Xuzhang Lu
OBJECTIVE: Todelineate the clinical and genetic features of a patient with myeloproliferative neoplasm (MPN) in association with PDGFRA and EVI1 genes rearrangements. METHODS: Clinical data of the patient was collected. Conventional cytogenetics, fluorescence in situ hybridization (FISH) and nested PCR were carried out for the patient. RESULTS: The patient has featured recurrent rash, joint pain, and intermittent fever. Laboratory tests showed hyperleukocytosis and marked eosinophilia...
February 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28168700/progenitor-genotyping-reveals-a-complex-clonal-architecture-in-a-subset-of-calr-mutated-myeloproliferative-neoplasms
#12
Sarah Martin, Casey M Wright, Linda M Scott
The identification of acquired CALR mutations in patients with essential thrombocythaemia (ET) or myelofibrosis (MF) has meant that disease-initiating mutations can now be detected in about 90% of all patients with a myeloproliferative neoplasm (MPN). Here, we show that only those CALR mutations that cause a +1 frameshift, thereby altering the carboxy-terminus of calreticulin, promote cytokine independence in vitro; in-frame deletions were not functional, and are unlikely to be the pathogenetic mutation underlying some MPN cases...
February 7, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28167129/jak-stat-signaling-in-the-therapeutic-landscape-of-myeloproliferative-neoplasms
#13
Jennifer M O'Sullivan, Claire N Harrison
Myeloproliferative neoplasms (MPN) are a group of disorders defined by clonal proliferation of mature myeloid cells with overlapping clinical features. The driver mutations of these disorders, namely JAK2 (Janus Kinase), MPL (Myeloproliferative Leukaemia Virus) and CALR (Calreticulin) upregulate JAK-STAT signaling with increase in downstream transcription and gene expression. Epigenetic mutations are prevalent in MPNs but their interplay with aberrant JAK-STAT signaling is not known. This understanding lead to development of first targeted treatment in MPN; ruxolitinib for primary myelofibrosis...
February 3, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28164415/e-coli-contamination-of-child-complementary-foods-and-association-with-domestic-hygiene-in-rural-bangladesh
#14
Sarker Masud Parvez, Laura Kwong, Musarrat Jabeen Rahman, Ayse Ercumen, Amy J Pickering, Probir K Ghosh, Md Zahidur Rahman, Kishor Kumar Das, Stephen P Luby, Leanne Unicomb
OBJECTIVE: To determine the frequency and concentration of E. coli in child complementary food and its association with domestic hygiene practices in rural Bangladesh. METHOD: 608 households with children <2 years were enrolled. We collected stored complementary food samples, performed spot checks on domestic hygiene and measured ambient temperature in the food storage area. Food samples were analyzed using the IDEXX most probable number (MPN) method with Colilert-18 media to enumerate E...
February 6, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28159736/myeloproliferative-neoplasm-stem-cells
#15
Adam J Mead, Ann Mullally
Myeloproliferative neoplasms (MPN) arise in the hematopoietic stem cell (HSC) compartment as a result of the acquisition of somatic mutations in a single HSC that provide a selective advantage to mutant HSC over normal HSC and promote myeloid differentiation to engender a myeloproliferative phenotype. This population of somatically mutated HSC, which initiate and sustain MPN, are termed MPN stem cells. In greater than 95% of cases, mutations that drive the development of an MPN phenotype occur in a mutually exclusive manner in one of three genes: JAK2, CALR or MPL The thrombopoietin receptor, MPL is the key cytokine receptor in MPN development and these mutations all activate MPL-JAK-STAT signaling in MPN stem cells...
February 3, 2017: Blood
https://www.readbyqxmd.com/read/28153839/mds-mpn-with-ring-sideroblasts-and-thrombocytosis-masquerading-as-prefibrotic-early-primary-myelofibrosis
#16
Zhaodong Xu
No abstract text is available yet for this article.
February 2, 2017: Blood
https://www.readbyqxmd.com/read/28118573/validation-of-medi%C3%A2-ca-ec-method-for-aoac-research-institute-performance-tested-methodssm-certification-certificate-no-031601
#17
Mai Shimizu, Fumihiko Saito, Kentaro Takenaka, Narumi Kimura, Takeo Suzuki, Tatsuhiko Iwase, Hitoshi Kyotani
A ready-made dry medium method for <em>Escherichia coli</em> and coliform count, the Medi•Ca EC method, wascompared with the most probable number (MPN) method using Brilliant Green Lactose Bile broth and <em>E. coli</em> broth (AOAC INTERNATIONAL <em>Official Method</em><sup>SM</sup> <strong>966.24</strong>) for seven food matrixes: raw beef, raw pork, raw frozen pork, raw lamb, raw salmon, frankfurter sausage, and cooked ham. The mean difference between the two methods at each contamination level for each matrix was <0...
December 21, 2016: Journal of AOAC International
https://www.readbyqxmd.com/read/28117485/evaluation-of-a-most-probable-number-method-for-the-enumeration-of-legionella-pneumophila-from-potable-and-related-water-samples
#18
D P Sartory, K Spies, B Lange, S Schneider, B Langer
This study compared the performance of a novel MPN method (Legiolert/Quanti-Tray) with the ISO 11731-2 membrane filtration method for the enumeration of L. pneumophila from 100 ml potable water and related samples. Data from a multi-laboratory study analysed according to ISO 17994 showed that Legiolert(™) /Quanti-Tray(®) yielded on average higher counts of L. pneumophila. The Legiolert medium had a high specificity of 96.4%. The new method represents a significant improvement in the enumeration of L. pneumophila from drinking water related samples...
January 24, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28115216/mysm1-deficiency-genotoxic-stress-associated-bone-marrow-failure-and-developmental-aberrations
#19
Ehsan Bahrami, Maximilian Witzel, Tomas Racek, Jacek Puchałka, Sebastian Hollizeck, Naschla Greif-Kohistani, Daniel Kotlarz, Hans-Peter Horny, Regina Feederle, Heinrich Schmidt, Roya Sherkat, Doris Steinemann, Gudrun Göhring, Brigitte Schlegelbeger, Michael H Albert, Waleed Al-Herz, Christoph Klein
BACKGROUND: Myb-Like, SWIRM and MPN domains 1 (MYSM1) is a transcriptional regulator mediating histone deubiquitination. Its role in human immunity and hematopoiesis is poorly understood. OBJECTIVES: To investigate the clinical, cellular and molecular features in two siblings presenting with progressive bone marrow failure, immunodeficiency and developmental aberrations. METHODS: We performed genome-wide homozygosity mapping, whole-exome sequencing (WES) and Sanger sequencing, immunophenotyping studies as well as analysis of genotoxic stress responses...
January 20, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28099766/high-salinity-relaying-to-reduce-vibrio-parahaemolyticus-and-vibrio-vulnificus-in-chesapeake-bay-oysters-crassostrea-virginica
#20
Salina Parveen, Michael Jahncke, Sara Elmahdi, Helen Crocker, John Bowers, Chanelle White, Stephanie Gray, Amanda C Morris, Kathy Brohawn
Cases of Vibrio infections in the United States have tripled from 1996 to 2009 and these infections are most often associated with the consumption of seafood, particularly oysters (Crassostrea virginica). Information is needed on how to reduce numbers of Vibrio parahaemolyticus and Vibrio vulnificus in bi-valve molluscan shellfish (for example, oysters). The purpose of this study was to evaluate the effectiveness of high salinity relaying or treatment in recirculating aquaculture systems (RASs) as methods to reduce the abundance of V...
January 18, 2017: Journal of Food Science
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