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AV septal defect

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https://www.readbyqxmd.com/read/27900839/multicenter-midterm-follow-up-results-using-the-gore-septal-occluder-for-atrial-septal-defect-closure-in-pediatric-patients
#1
Jochen Grohmann, Christian Wildberg, Peter Zartner, Tariq Abu-Tair, Gleb Tarusinov, Erwin Kitzmüller, Claudia Schmoor, Brigitte Stiller, Christoph Kampmann
OBJECTIVES: To assess the safety and efficacy of the Gore Septal Occluder (GSO) used for device-closure of significant secundum-type atrial septal defects (ASD II) focusing on pediatric patients. BACKGROUND: The GSO is a patch-like double disc device. Due to its design, it is assumed to be safe, even when implanted in ASDs with deficient retro-aortic rims. METHODS: Multicenter retrospective analysis of consecutive children and adolescents with a GSO in situ for at least 12 months according to a 1- to 4-year midterm follow-up...
November 30, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27867454/predictors-for-the-outcome-of-aortic-regurgitation-after-cardiac-surgery-in-patients-with-ventricular-septal-defect-and-aortic-cusp-prolapse-in-saudi-patients
#2
Hiba Gaafar Salih, Sameh R Ismail, Mohamed S Kabbani, Riyadh M Abu-Sulaiman
BACKGROUND AND AIM: Aortic valve (AV) prolapse and subsequent aortic regurgitation (AR) are two complications of ventricular septal defects (VSD) that are located close to or in direct contact with the AV. This finding is one of the indications for surgical VSD closure even in the absence of symptoms to protect the AV integrity. The goal of our study was to assess the outcome and to identify the predictors for improvement or progression of AR after surgical repair. MATERIALS AND METHODS: A retrospective study of all children with VSD and AV prolapse who underwent cardiac surgery at King Abdulaziz Cardiac Centre in Riyadh between July 1999 and August 2013...
July 2016: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/27847970/interventional-vsd-closure-with-the-nit-occlud-%C3%A2-l%C3%A3%C2%AA-vsd-coil-in-110-patients-early-and-midterm-results-of-the-eureveco-registry
#3
Nikolaus A Haas, Laura Kock, Harald Bertram, Regina Boekenkamp, Daniel De Wolf, Igor Ditkivskyy, Matthias W Freund, Marc Gewillig, Christoph M Happel, Ulrike Herberg, Edvard Karthasyan, Rainer Kozlik-Feldmann, Oliver Kretschmar, Yulia Kuzmenko, Ornella Milanesi, Goetz Mueller, Giacomo Pongiglione, Stephan Schubert, Gleb Tarusinov, Christoph Kampmann
In August 2010, the Nit-Occlud(®) Lê (EUREVECO) became available for transcatheter coil occlusion of ventricular septal defects (VSDs). Retrospective European Registry for VSD Closure using the Nit-Occlud(®) Lê-VSD-Coil; analysis of the feasibility, results, safety and follow-up of VSD-closure over a 3-year period in 18 European centers. In 102 of 111 patients (female 66), successful VSD closure was performed (mean age 8.2 years, mean weight 28.82 kg), 81 perimembranous VSDs (48 with aneurysm), 30 muscular VSDs, mean procedure time was 121...
November 15, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27834986/echocardiographic-predictors-of-left-ventricular-outflow-tract-obstruction-following-repair-of-atrioventricular-septal-defect
#4
Ginnie L Abarbanell, Gemma Morrow, Michael S Kelleman, Kirk R Kanter, William L Border, Ritu Sachdeva
BACKGROUND: Left ventricular outflow tract obstruction (LVOTO) is a common complication following surgical repair of atrioventricular septal defect (AVSD). OBJECTIVE: We sought to determine predictors of LVOTO based on echocardiograms performed prior to initial repair of AVSD. METHODS: Of the 415 children that had repair of AVSD from 2003 to 2012, 17 children were identified with LVOTO that required surgical intervention. Thirty-four patients with repaired AVSD and no LVOTO served as controls...
May 12, 2016: Congenital Heart Disease
https://www.readbyqxmd.com/read/27739163/interpreting-measurements-of-cardiac-function-using-vendor-independent-speckle-tracking-echocardiography-in-children-a-prospective-blinded-comparison-with-catheter-derived-measurements
#5
Suma P Goudar, G Hamilton Baker, Shahryar M Chowdhury, Kimberly J Reid, Girish Shirali, Mark A Scheurer
BACKGROUND: Adult studies demonstrate that echocardiographic measurements of cardiac function using speckle tracking correlate with invasive measurements, but such data in the pediatric population are sparse. Our aim was to compare speckle-derived measures of cardiac function to measurements routinely obtained by cardiac catheterization in children. METHODS: Echocardiograms were performed on the day of cardiac catheterization. Using Tomtec 2D Cardiac Performance Analysis, longitudinal strain (LS), longitudinal strain rate (LSR), early diastolic LSR, and ejection fraction (EF) for the right and left ventricle (RV and LV) were calculated via speckle tracking...
December 2016: Echocardiography
https://www.readbyqxmd.com/read/27580238/14-3-3epsilon-controls-multiple-developmental-processes-in-the-mouse-heart
#6
Adriana C Gittenberger-de Groot, Tamara Hoppenbrouwers, Lucile Miquerol, Yasuhiro Kosaka, Robert E Poelmann, Lambertus J Wisse, H Joseph Yost, Monique R M Jongbloed, Marco C Deruiter, Luca Brunelli
BACKGROUND: 14-3-3ε plays an important role in the maturation of the compact ventricular myocardium by modulating the cardiomyocyte cell cycle via p27(kip1) . However, additional cardiac defects are possible given the ubiquitous expression pattern of this protein. RESULTS: Germ line deletion of 14-3-3ε led to malalignment of both the outflow tract (OFT) and atrioventricular (AV) cushions, with resulting tricuspid stenosis and atresia, mitral valve abnormalities, and perimembranous ventricular septal defects (VSDs)...
November 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27556898/embryonic-ethanol-exposure-dysregulates-bmp-and-notch-signaling-leading-to-persistent-atrio-ventricular-valve-defects-in-zebrafish
#7
Swapnalee Sarmah, Pooja Muralidharan, James A Marrs
Fetal alcohol spectrum disorder (FASD), birth defects associated with ethanol exposure in utero, includes a wide spectrum of congenital heart defects (CHDs), the most prevalent of which are septal and conotruncal defects. Zebrafish FASD model was used to dissect the mechanisms underlying FASD-associated CHDs. Embryonic ethanol exposure (3-24 hours post fertilization) led to defects in atrio-ventricular (AV) valvulogenesis beginning around 37 hpf, a morphogenetic event that arises long after ethanol withdrawal...
2016: PloS One
https://www.readbyqxmd.com/read/27540418/atrioventricular-block-after-asd-closure
#8
Hiroko Asakai, Sofia Weskamp, Lucas Eastaugh, Yves d'Udekem, Andreas Pflaumer
OBJECTIVE: Secundum atrial septal defect (ASD) is a common congenital heart defect. There is limited data on both early and late atrioventricular (AV) block post ASD closure. The aim of this study was to determine the incidence and risk factors of AV block associated with ASD closure. METHODS: A retrospective analysis of all patients who underwent ASD closure either with a device or surgical method at the Royal Children's Hospital Melbourne between 1996 and 2010 was performed...
2016: Heart Asia
https://www.readbyqxmd.com/read/27426723/congenital-heart-diseases-and-their-association-with-the-variant-distribution-features-on-susceptibility-genes
#9
W Su, P Zhu, R Wang, Q Wu, M Wang, X Zhang, L Mei, J Tang, M Kumar, X Wang, L Su, N Dong
Congenital heart disease (CHD), one of the causes of childhood morbidity and mortality, is mainly triggered by a combination of environmental and genetic factors. Several susceptible genes, such as NKX2-5, GATA4 and TBX5, have been reported as closely related to heart and vessel development. CHD subtypes are classified into diverse clinical phenotypes, such as atrial septal defects (ASD), ventricular septal defects (VSD), tetralogy of Fallot (TOF), and Holt-Oram syndrome (HOS). Here, we summarize the associations of the genetic variants in these three genes with CHD subtypes...
July 18, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/27112649/repair-of-partial-atrioventricular-septal-defect-age-and-outcomes
#10
Paul J Devlin, Carl L Backer, Osama Eltayeb, Michael C Mongé, Amanda L Hauck, John M Costello
BACKGROUND: We evaluated the outcomes of patients undergoing surgical repair of partial atrioventricular septal defect (AVSD) and analyzed the effect of age on outcome. METHODS: In this single-center retrospective study, we included all children who underwent repair of partial AVSD between 1990 and 2014. We divided the patients into 4 age quartiles (first quartile: 0-0.75 years, n = 22; second quartile: 0.75-1.5 years, n = 21; third quartile: 1.5-3.75 years, n = 22; and fourth quartile: >3...
July 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27029396/closure-of-secundum-atrial-septal-defects-by-using-the-occlutech-occluder-devices-in-more-than-1300-patients-the-irfacode-project-a-retrospective-case-series
#11
Nikolaus A Haas, Dagmar B Soetemann, Ismail Ates, Osman Baspinar, Igor Ditkivskyy, Christopher Duke, Francois Godart, Avraham Lorber, Edmundo Oliveira, Eustaquio Onorato, Feyza Pac, Worakan Promphan, Frank-Thomas Riede, Supaporn Roymanee, Robert Sabiniewicz, Suhair Omar Shebani, Horst Sievert, Do Tin, Christoph M Happel
BACKGROUND: The Occlutech Figulla ASD device series (OFSO) shows an improved device design for interventional ASD closure, larger follow-up series are missing. METHODS: We retrospectively reviewed the feasibility, safety, implantation properties, results, and follow-up of ASD closure using Occlutech devices over a 5 year period by establishing a multi-institutional collaborative result registry with 16 contributing centers from 11 countries (IRFACODE). RESULTS: In 1315 patients of all age groups (female 66...
March 31, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/26931266/incomplete-pentalogy-of-cantrell-a-case-report
#12
M A Ali, T Tazmin, T Latif, S A Haque, M A Hossain, M N Islam, R H Khan, M A Hoque
Cantrell's Pentalogy is a rare congenital malformation consists of supraumbilical abdominal wall defect, defect in the lower part of sternum, agenesis of anterior portion of diaphragm, an absence of the diaphragmatic part of the pericardium and intracardiac malformation. This case report presents a female neonate, who was born at 40 weeks of gestation weighing 2400 gm and was admitted 4 hours after delivery with the complaints of something coming out from chest. On physical examination her vital signs were within normal limit, she had a systolic murmur on heart at lower left sternal area and there was a vascular structure present on the upper part of abdomen which was pulsatile and pulsation was synchronized with cardiac pulsation...
January 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/26901898/gerbode-defect-as-a-result-of-fungal-aortic-valve-endocarditis
#13
Chetan Pasrija, Isa Mohammed, Inna Shats, Susie Hong-Zohlman, Junewai Reoma, Michael A Mazzeffi, Keshava Rajagopal
A 63-year-old male patient with HIV disease presented with dyspnea and complete heart block, and was found to have aortic valve (AV) endocarditis secondary to Candida parapsilosis infection. Echocardiography demonstrated AV endocarditis and possible aortic root versus subannular abscess with moderate AV regurgitation (AR), a ventricular septal defect (VSD) and possible left ventricular to right atrial shunt (Gerbode defect). Large AV vegetations, subannular abscess with an acquired membranous VSD, Gerbode defect, and tricuspid annular abscess at the insertion of septal leaflet were noted intraoperatively...
May 2015: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/26882979/absent-left-main-coronary-artery-and-separate-ostia-of-left-coronary-system-in-a-patient-with-holt-oram-syndrome-and-sinus-node-dysfunction
#14
Thein Tun Aung, Edward Samuel Roberto, Abdul Wase
BACKGROUND: Holt-Oram syndrome (HOS) is a rare but significant syndrome consisting of structural heart defects, conduction abnormalities, and upper extremity anomalies. It was first described in the British Heart Journal in 1960 by Mary Holt and Samuel Oram as a report of atrial septal defect, conduction disturbances, and hand malformations occurring in family members. Patients can present with heart blocks or symptoms of underlying congenital heart defects. CASE REPORT: A 41-year-old man with Holt-Oram syndrome presented with seizure-like activity and was found to have an underlying conduction disturbance...
2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/26685152/surgical-repair-of-partial-atrioventricular-defect
#15
Issam El-Rassi, Fatimah Charafedine, Mariane Majdalani, Mariam Arabi, Daniele Khater, Fadi Bitar
Long-term survival rate of patients operated for partial atrioventricular (AV) canal is lower than that of the general population, and late complications are relatively significant: between 10 and 30% of operated patients present with left AV valve regurgitation, and up to 25% have to be reoperated for valve repair or replacement, left ventricular outflow tract obstruction or residual atrial septal defect. Because the left AV valve regurgitation is the most common complication following surgery, technical details in the surgical management of the mitral valve are the most important aspects of this procedure; for example, the decision to close the cleft and to perform an annuloplasty...
2015: Multimedia Manual of Cardiothoracic Surgery: MMCTS
https://www.readbyqxmd.com/read/26638005/ct-imaging-features-of-atrioventricular-shunts-what-the-radiologist-must-know
#16
Simon Nicolay, Rodrigo A Salgado, Bharati Shivalkar, Paul L Van Herck, Christiaan Vrints, Paul M Parizel
UNLABELLED: In the last decade, cardiac computed tomography (CT) has gained mainstream acceptance for the noninvasive exclusion of significant coronary disease in a selected population. Improvements in electrocardiogram (ECG)-triggered imaging techniques also allow, by extension, a proper evaluation of the complete heart anatomy. Given the increasing worldwide clinical implementation of cardiac CT for coronary artery evaluation, radiologists can, incidentally, be confronted with unfamiliar and previously unsuspected non-coronary cardiac pathologies, including congenital morphological defects...
February 2016: Insights Into Imaging
https://www.readbyqxmd.com/read/26408089/screening-performances-of-abnormal-first-trimester-ductus-venosus-blood-flow-and-increased-nuchal-translucency-thickness-in-detection-of-major-heart-defects
#17
Natasa Karadzov-Orlic, Amira Egic, Dejan Filimonovic, Barbara Damnjanovic-Pazin, Zagorka Milovanovic, Relja Lukic, Vesna Mandic, Ivana Joksic, Vladimir Vukomanovic, Jovan Kosutic, Slavisa Djuricic, Zeljko Mikovic
OBJECTIVE: The aim of this study was to evaluate the screening performances of abnormal ductus venosus (DV) blood flow for the detection of heart defects in chromosomally normal fetuses with increased nuchal translucency (NT) thickness at 11-13 + 6 weeks' gestational in a population of singleton pregnancies. METHODS: During an 8-year period, all singleton pregnancies from 11 + 0 to 13 + 6 weeks were scanned for NT and DV blood flow assessment. Two groups of cases with abnormal NT were evaluated: NT ≥ 95th and NT ≥ 99th centile...
December 2015: Prenatal Diagnosis
https://www.readbyqxmd.com/read/26377366/anatomical-repair-of-an-unusual-combination-of-tetralogy-of-fallot-and-atrioventricular-septal-defect-with-unroofed-coronary-sinus
#18
Sachin Talwar, Rakesh Kumar, Amolkumar Bhoje, Shiv Kumar Choudhary, Balram Airan
A 30-month-old female was admitted with recurrent spells and severe cyanosis. Preoperative echocardiography was diagnostic of tetralogy of Fallot with an atrial septal defect of the primum type, unroofed coronary sinus, and a left superior vena cava draining into the left atrium. At surgery the patient was found to have a complete atrioventricular septal defect in addition to these anomalies. Complete anatomical correction was achieved through the right atrial approach.
November 2015: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/26376067/a-novel-mutation-of-gata4-k300t-associated-with-familial-atrial-septal-defect
#19
Jia Chen, Bingyang Qi, Juan Zhao, Wei Liu, Ranhui Duan, Mingqiu Zhang
The GATA-binding protein 4 gene (GATA4) encodes a zinc-finger transcription factor that plays a key role in embryogenesis and cardiac development. Variants in the GATA4 gene have been implicated in several congenital heart diseases (CHD), such as the tetralogy of Fallot (ToF), atrial septal defect (ASD), ventricular septal defect (VSD), atrioventricular septal defect (AVSD), and dilated cardiomyopathy (DCM). We studied a four-generation Chinese ASD family and identified a novel GATA4 mutation (c.A899C, p.K300T) in all surviving affected members and two carriers with incomplete penetrance...
January 10, 2016: Gene
https://www.readbyqxmd.com/read/26354653/two-strip-technique-to-repair-common-atrioventricular-valve-regurgitation-in-single-ventricle-palliation
#20
Kasra Shaikhrezai, Karen McLeod, Brodie Knight, Mark H D Danton
A common atrioventricular valve (CAVV) presents a challenge in single-ventricle palliation (SVP) because of its propensity to leak, with CAVV regurgitation being an important risk factor for repeated operation and mortality. We propose a new technique of CAVV repair in the context of SVP. The method uses the techniques of complete repair of antrioventricular septal defect while maintaining free communication at atrial and ventricular levels necessary for single-ventricle physiology.
September 2015: Annals of Thoracic Surgery
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