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AV septal defect

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https://www.readbyqxmd.com/read/28633249/augmentation-of-bridging-leaflets-in-repair-of-atrioventricular-canal-defects
#1
Christopher W Baird, Christian Kreutzer, Stephen P Sanders, Michele J Borisuk, Pedro J Del Nido
Left atrioventricular (AV) valve regurgitation is the most common complication after a atrioventricular canal defect (AVCD) repair. Despite what appears to be a less complex repair, patients with partial and transitional AV canal have higher reoperation rates for left AV valve regurgitation and left ventricular outflow tract (LVOT) obstruction. Retraction of bridging leaflets with secondary attachments to the septal crest commonly produces increased tension and flattening of the medial left AV valve leaflet and LVOT obstruction after cleft closure...
July 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28523023/surgical-repair-of-partial-atrioventricular-septal-defect
#2
Tariq Waqar, Muhammad Usman Riaz, Muhammad Shuaib
OBJECTIVE: To review the results of surgical correction of partial atrioventricular septal defect and associated cardiac comorbidities. METHODS: Retrospective case analysis of electronic database of department of paediatrics cardiac surgery, CPEIC, Multan was done. Forty consecutive patients operated for partial atrioventricular septal defect repair from September 2011 to October 2016 were included. Mean age was 14.67±7.96 years. 60% (24) patients were male. Regarding echocardiographic findings, pre-operatively 40% (n=16) had mild, 47...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28520544/repair-of-complete-atrioventricular-septal-defects-with-decellularized-extracellular-matrix-initial-and-midterm-outcomes
#3
Adeel Ashfaq, Tyler Brown, Brian Reemtsen
OBJECTIVE: Since April 2010, our institution has repaired complete atrioventricular septal defects (CAVSDs) with a two-patch technique utilizing CorMatrix extracellular material. This material is potentially an attractive patch because of its theorized eventual integration with the host tissue. We sought to analyze initial outcomes of CAVSD repair with CorMatrix. METHODS: Data were collected on consecutive pediatric (age <18) patients receiving two-patch CAVSD repairs with CorMatrix at a single institution from April 2010 to July 2014...
May 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28315566/directly-ventricular-septal-defect-closure-without-using-arteriovenous-wire-loop-our-adult-case-series-using-transarterial-retrograde-approach
#4
Nihat Pekel, Ertuğrul Ercan, Mehmet Emre Özpelit, Ferhat Özyurtlu, Akar Yılmaz, Caner Topaloğlu, Serkan Saygı, Serkan Yakan, İstemihan Tengiz
OBJECTIVE: The standard transcatheter ventricular septal defects (VSD) closure procedure is established with arteriovenous (AV) loop and is called as antegrade approach. The directly retrograde transarterial VSD closure without using AV loop might be better option as shortens the procedure time and decreases radiation exposure. METHODS: Our series consist of twelve sequential adult cases with congenital VSDs (seven with perimembranous, four with muscular, one with postoperative residuel VSD)...
February 21, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28302382/congenital-heart-defect-causing-mutation-in-nkx2-5-displays-in-vivo-functional-deficit
#5
Abeer F Zakariyah, Rashida F Rajgara, John P Veinot, Ilona S Skerjanc, Patrick G Burgon
The Nkx2.5 gene encodes a transcription factor that plays a critical role in heart development. In humans, heterozygous mutations in NKX2.5 result in congenital heart defects (CHDs). However, the molecular mechanisms by which these mutations cause the disease remain unknown. NKX2.5-R142C is a mutation that was reported to be associated with atrial septal defect (ASD) and atrioventricular (AV) block in 13-patients from one family. The R142C mutation is located within both the DNA-binding domain and the nuclear localization sequence of NKX2...
April 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28296023/closure-of-patent-foramen-ovale-defects-using-gore%C3%A2-cardioform-septal-occluder
#6
Stefan E Hardt, Andreas Eicken, Felix Berger, Stephan Schubert, Mario Carminati, Gianfranco Butera, Jochen Grohmann, Rene Höhn, Jens Erik Nielsen-Kudsk, David Hildick-Smith, Magnus Settergren, John D Thomson, Nicolas Geis, Lars Søndergaard
AIMS: The GORE® CARDIOFORM Septal Occluder (GSO) is a novel device designed for rapid and effective closure of patent foramen ovale (PFO) which has distinctive features making it suitable for a broad spectrum of anatomical variations. We report the procedural and 6 months follow-up results of the first prospective, multicenter study using GSO. METHODS AND RESULTS: This single-arm study included 150 subjects undergoing closure of PFO in 10 European centers. In 149 out of 150 patients implantation of a GSO device was successful...
March 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28211263/increased-regurgitant-flow-causes-endocardial-cushion-defects-in-an-avian-embryonic-model-of-congenital-heart-disease
#7
Stephanie M Ford, Matthew T McPheeters, Yves T Wang, Pei Ma, Shi Gu, James Strainic, Christopher Snyder, Andrew M Rollins, Michiko Watanabe, Michael W Jenkins
BACKGROUND: The relationship between changes in endocardial cushion and resultant congenital heart diseases (CHD) has yet to be established. It has been shown that increased regurgitant flow early in embryonic heart development leads to endocardial cushion defects, but it remains unclear how abnormal endocardial cushions during the looping stages might affect the fully septated heart. The goal of this study was to reproducibly alter blood flow in vivo and then quantify the resultant effects on morphology of endocardial cushions in the looping heart and on CHDs in the septated heart...
May 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28108755/measurement-of-aortic-valve-coaptation-and-effective-height-using-echocardiography-in-patients-with-ventricular-septal-defects-and-aortic-valve-prolapse
#8
Satoru Iwashima, Hiroki Uchiyama, Takamichi Ishikawa, Kiyohiro Takigiku, Ken Takahashi, Manatomo Toyono, Nao Inoue, Masaki Nii
Decreased coaptation height in adults has been identified as a marker of early valve failure. We evaluated aortic valve coaptation and effective height in healthy children and in children with a ventricular septal defect (VSD) with aortic cusp prolapse (ACP), using echocardiography. We included 45 subjects with VSD with ACP, 27 did not develop aortic regurgitation (AR) by ACP and 18 developed AR by ACP, and 83 healthy children as controls. Aortic root anatomy was estimated using the parasternal long-axis view...
March 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28072626/acquired-coronary-artery-disease-in-adult-patients-with-congenital-heart-disease-a-true-or-a-false-problem
#9
Alessandro Giamberti, Mauro Lo Rito, Erika Conforti, Alessandro Varrica, Mario Carminati, Alessandro Frigiola, Lorenzo Menicanti, Massimo Chessa
BACKGROUND: The population of adults with congenital heart disease (ACHD) is increasing and aging, and a large percentage of this population is now over 65 years of age. For this reason, it is probable that acquired coronary artery disease (CAD) will become an important issue that needs to be addressed also in these patients. We retrospectively analyzed all ACHD patients who underwent surgery in our Institution with the aim to investigate the incidence of associated CAD and the results of surgical treatment...
January 7, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/27900839/multicenter-midterm-follow-up-results-using-the-gore-septal-occluder-for-atrial-septal-defect-closure-in-pediatric-patients
#10
Jochen Grohmann, Christian Wildberg, Peter Zartner, Tariq Abu-Tair, Gleb Tarusinov, Erwin Kitzmüller, Claudia Schmoor, Brigitte Stiller, Christoph Kampmann
OBJECTIVES: To assess the safety and efficacy of the Gore Septal Occluder (GSO) used for device-closure of significant secundum-type atrial septal defects (ASD II) focusing on pediatric patients. BACKGROUND: The GSO is a patch-like double disc device. Due to its design, it is assumed to be safe, even when implanted in ASDs with deficient retro-aortic rims. METHODS: Multicenter retrospective analysis of consecutive children and adolescents with a GSO in situ for at least 12 months according to a 1- to 4-year midterm follow-up...
November 30, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27867454/predictors-for-the-outcome-of-aortic-regurgitation-after-cardiac-surgery-in-patients-with-ventricular-septal-defect-and-aortic-cusp-prolapse-in-saudi-patients
#11
Hiba Gaafar Salih, Sameh R Ismail, Mohamed S Kabbani, Riyadh M Abu-Sulaiman
BACKGROUND AND AIM: Aortic valve (AV) prolapse and subsequent aortic regurgitation (AR) are two complications of ventricular septal defects (VSD) that are located close to or in direct contact with the AV. This finding is one of the indications for surgical VSD closure even in the absence of symptoms to protect the AV integrity. The goal of our study was to assess the outcome and to identify the predictors for improvement or progression of AR after surgical repair. MATERIALS AND METHODS: A retrospective study of all children with VSD and AV prolapse who underwent cardiac surgery at King Abdulaziz Cardiac Centre in Riyadh between July 1999 and August 2013...
July 2016: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/27847970/interventional-vsd-closure-with-the-nit-occlud-%C3%A2-l%C3%A3%C2%AA-vsd-coil-in-110-patients-early-and-midterm-results-of-the-eureveco-registry
#12
MULTICENTER STUDY
Nikolaus A Haas, Laura Kock, Harald Bertram, Regina Boekenkamp, Daniel De Wolf, Igor Ditkivskyy, Matthias W Freund, Marc Gewillig, Christoph M Happel, Ulrike Herberg, Edvard Karthasyan, Rainer Kozlik-Feldmann, Oliver Kretschmar, Yulia Kuzmenko, Ornella Milanesi, Goetz Mueller, Giacomo Pongiglione, Stephan Schubert, Gleb Tarusinov, Christoph Kampmann
In August 2010, the Nit-Occlud(®) Lê (EUREVECO) became available for transcatheter coil occlusion of ventricular septal defects (VSDs). Retrospective European Registry for VSD Closure using the Nit-Occlud(®) Lê-VSD-Coil; analysis of the feasibility, results, safety and follow-up of VSD-closure over a 3-year period in 18 European centers. In 102 of 111 patients (female 66), successful VSD closure was performed (mean age 8.2 years, mean weight 28.82 kg), 81 perimembranous VSDs (48 with aneurysm), 30 muscular VSDs, mean procedure time was 121...
February 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/27834986/echocardiographic-predictors-of-left-ventricular-outflow-tract-obstruction-following-repair-of-atrioventricular-septal-defect
#13
Ginnie L Abarbanell, Gemma Morrow, Michael S Kelleman, Kirk R Kanter, William L Border, Ritu Sachdeva
BACKGROUND: Left ventricular outflow tract obstruction (LVOTO) is a common complication following surgical repair of atrioventricular septal defect (AVSD). OBJECTIVE: We sought to determine predictors of LVOTO based on echocardiograms performed prior to initial repair of AVSD. METHODS: Of the 415 children that had repair of AVSD from 2003 to 2012, 17 children were identified with LVOTO that required surgical intervention. Thirty-four patients with repaired AVSD and no LVOTO served as controls...
May 12, 2016: Congenital Heart Disease
https://www.readbyqxmd.com/read/27739163/interpreting-measurements-of-cardiac-function-using-vendor-independent-speckle-tracking-echocardiography-in-children-a-prospective-blinded-comparison-with-catheter-derived-measurements
#14
Suma P Goudar, G Hamilton Baker, Shahryar M Chowdhury, Kimberly J Reid, Girish Shirali, Mark A Scheurer
BACKGROUND: Adult studies demonstrate that echocardiographic measurements of cardiac function using speckle tracking correlate with invasive measurements, but such data in the pediatric population are sparse. Our aim was to compare speckle-derived measures of cardiac function to measurements routinely obtained by cardiac catheterization in children. METHODS: Echocardiograms were performed on the day of cardiac catheterization. Using Tomtec 2D Cardiac Performance Analysis, longitudinal strain (LS), longitudinal strain rate (LSR), early diastolic LSR, and ejection fraction (EF) for the right and left ventricle (RV and LV) were calculated via speckle tracking...
December 2016: Echocardiography
https://www.readbyqxmd.com/read/27580238/14-3-3epsilon-controls-multiple-developmental-processes-in-the-mouse-heart
#15
Adriana C Gittenberger-de Groot, Tamara Hoppenbrouwers, Lucile Miquerol, Yasuhiro Kosaka, Robert E Poelmann, Lambertus J Wisse, H Joseph Yost, Monique R M Jongbloed, Marco C Deruiter, Luca Brunelli
BACKGROUND: 14-3-3ε plays an important role in the maturation of the compact ventricular myocardium by modulating the cardiomyocyte cell cycle via p27(kip1) . However, additional cardiac defects are possible given the ubiquitous expression pattern of this protein. RESULTS: Germ line deletion of 14-3-3ε led to malalignment of both the outflow tract (OFT) and atrioventricular (AV) cushions, with resulting tricuspid stenosis and atresia, mitral valve abnormalities, and perimembranous ventricular septal defects (VSDs)...
November 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27556898/embryonic-ethanol-exposure-dysregulates-bmp-and-notch-signaling-leading-to-persistent-atrio-ventricular-valve-defects-in-zebrafish
#16
Swapnalee Sarmah, Pooja Muralidharan, James A Marrs
Fetal alcohol spectrum disorder (FASD), birth defects associated with ethanol exposure in utero, includes a wide spectrum of congenital heart defects (CHDs), the most prevalent of which are septal and conotruncal defects. Zebrafish FASD model was used to dissect the mechanisms underlying FASD-associated CHDs. Embryonic ethanol exposure (3-24 hours post fertilization) led to defects in atrio-ventricular (AV) valvulogenesis beginning around 37 hpf, a morphogenetic event that arises long after ethanol withdrawal...
2016: PloS One
https://www.readbyqxmd.com/read/27540418/atrioventricular-block-after-asd-closure
#17
Hiroko Asakai, Sofia Weskamp, Lucas Eastaugh, Yves d'Udekem, Andreas Pflaumer
OBJECTIVE: Secundum atrial septal defect (ASD) is a common congenital heart defect. There is limited data on both early and late atrioventricular (AV) block post ASD closure. The aim of this study was to determine the incidence and risk factors of AV block associated with ASD closure. METHODS: A retrospective analysis of all patients who underwent ASD closure either with a device or surgical method at the Royal Children's Hospital Melbourne between 1996 and 2010 was performed...
2016: Heart Asia
https://www.readbyqxmd.com/read/27426723/congenital-heart-diseases-and-their-association-with-the-variant-distribution-features-on-susceptibility-genes
#18
REVIEW
W Su, P Zhu, R Wang, Q Wu, M Wang, X Zhang, L Mei, J Tang, M Kumar, X Wang, L Su, N Dong
Congenital heart disease (CHD), one of the causes of childhood morbidity and mortality, is mainly triggered by a combination of environmental and genetic factors. Several susceptible genes, such as NKX2-5, GATA4 and TBX5, have been reported as closely related to heart and vessel development. CHD subtypes are classified into diverse clinical phenotypes, such as atrial septal defects (ASD), ventricular septal defects (VSD), tetralogy of Fallot (TOF), and Holt-Oram syndrome (HOS). Here, we summarize the associations of the genetic variants in these three genes with CHD subtypes...
March 2017: Clinical Genetics
https://www.readbyqxmd.com/read/27112649/repair-of-partial-atrioventricular-septal-defect-age-and-outcomes
#19
Paul J Devlin, Carl L Backer, Osama Eltayeb, Michael C Mongé, Amanda L Hauck, John M Costello
BACKGROUND: We evaluated the outcomes of patients undergoing surgical repair of partial atrioventricular septal defect (AVSD) and analyzed the effect of age on outcome. METHODS: In this single-center retrospective study, we included all children who underwent repair of partial AVSD between 1990 and 2014. We divided the patients into 4 age quartiles (first quartile: 0-0.75 years, n = 22; second quartile: 0.75-1.5 years, n = 21; third quartile: 1.5-3.75 years, n = 22; and fourth quartile: >3...
July 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27029396/closure-of-secundum-atrial-septal-defects-by-using-the-occlutech-occluder-devices-in-more-than-1300-patients-the-irfacode-project-a-retrospective-case-series
#20
MULTICENTER STUDY
Nikolaus A Haas, Dagmar B Soetemann, Ismail Ates, Osman Baspinar, Igor Ditkivskyy, Christopher Duke, Francois Godart, Avraham Lorber, Edmundo Oliveira, Eustaquio Onorato, Feyza Pac, Worakan Promphan, Frank-Thomas Riede, Supaporn Roymanee, Robert Sabiniewicz, Suhair Omar Shebani, Horst Sievert, Do Tin, Christoph M Happel
BACKGROUND: The Occlutech Figulla ASD device series (OFSO) shows an improved device design for interventional ASD closure, larger follow-up series are missing. METHODS: We retrospectively reviewed the feasibility, safety, implantation properties, results, and follow-up of ASD closure using Occlutech devices over a 5 year period by establishing a multi-institutional collaborative result registry with 16 contributing centers from 11 countries (IRFACODE). RESULTS: In 1315 patients of all age groups (female 66...
October 2016: Catheterization and Cardiovascular Interventions
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