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Papillomavirus

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https://www.readbyqxmd.com/read/29471460/coaching-primary-care-clinics-for-hpv-vaccination-quality-improvement-comparing-in-person-and-webinar-implementation
#1
William A Calo, Melissa B Gilkey, Jennifer Leeman, Jennifer Heisler-MacKinnon, Chrystal Averette, Stephanie Sanchez, Melanie L Kornides, Noel T Brewer
State health departments commonly use quality improvement coaching as an implementation strategy for improving low human papillomavirus (HPV) vaccination coverage, but such coaching can be resource intensive. To explore opportunities for improving efficiency, we compared in-person and webinar delivery of coaching sessions on implementation outcomes, including reach, acceptability, and delivery cost. In 2015, we randomly assigned 148 high-volume primary care clinics in Illinois, Michigan, and Washington State to receive either in-person or webinar coaching...
February 20, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29471316/influence-of-prior-knowledge-of-human-papillomavirus-status-on-the-performance-of-cytology-screening
#2
Toni Ricardo Martins, Adhemar Longatto-Filho, Diane Cohen, Juliana Yukari Kodaira Viscondi, Luiz Mario Fuza, Lise Cury, Luisa Lina Villa, José Eduardo Levi, José Eluf-Neto
Objectives: This study aimed to evaluate the influence of prior knowledge of human papillomavirus (HPV) status in cervical cytopathology readings. Methods: Participants comprised 2,376 women who underwent parallel cytology and HPV-DNA testing. Smears were read twice by the same team, first with previous knowledge of HPV-DNA status. Results: Overall, 239 (10.2%) smears had their cytology classification altered by the HPV-informed review. Cytology readings with prior knowledge of the HPV status revealed 10...
February 17, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29470802/male-undergraduates-hpv-vaccination-behavior-implications-for-achieving-hpv-associated-cancer-equity
#3
Hee Yun Lee, Katherine Lust, Suzanne Vang, Jay Desai
Despite the availability of the human papillomavirus (HPV) vaccine for males, uptake of the vaccine has been low, particularly among young adult males. This study aimed to investigate the levels of HPV vaccination and predictors of HPV vaccine completion in college men ages 18-26. We analyzed data from the 2015 College Student Health Survey, which was administered at 17 post-secondary institutions in Midwest areas. We included only responses from male participants who were ages 18-26 years old, resulting in a sample size of 2516...
February 22, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29470654/-molecular-characterization-of-penile-cancer-literature-review-of-new-prognostic-markers-and-potential-therapeutic-targets
#4
REVIEW
M May, S D Brookman-May, T H Ecke, M Burger
Squamous cell carcinoma of the penis (SCCP) is a rare cancer type in Western industrialized nations; nevertheless, it shows an aggressive course of disease in advanced tumor stages with accordantly high recurrence and progression rates. While molecular biomarkers are not established in clinical routine for the management of SCCP patients yet, the accordant unmet need is enormous, as adequate biomarkers would be meaningful for prognostic determination, planning of modality and extent of primary therapy, indication for inguinal lymph node resection, adjuvant treatment, and as potential targets for specific systemic treatment...
February 22, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29470526/expression-of-yin-yang-1-in-cervical-cancer-and-its-correlation-with-e-cadherin-expression-and-hpv16-e6
#5
Wanxue Wang, Zhenni Yue, Zhengping Tian, Yiran Xie, Jiamiao Zhang, Yuanping She, Bing Yang, Yuan Ye, Yihua Yang
The molecular mechanisms of normal cervical squamous epithelium advancing to cervical intraepithelial neoplasia (CIN) and eventually to cervical squamous cell carcinoma (CSCC) are largely unknown. This study explored abnormal expression of Yin Yang 1 (YY1) in cervical cancer and its correlation with the expression of E-cadherin and human papillomavirus (HPV) 16 E6. YY1, E-cadherin and HPV16 E6 expression were detected by immunohistochemistry in 90 cervical tissue specimens collected from 30 patients with hysteromyoma, 15 patients with CIN I, 15 patients with CIN II-III, and 30 patients with CSCC...
2018: PloS One
https://www.readbyqxmd.com/read/29470358/is-vulvovaginal-lichen-planus-associated-with-squamous-cell-carcinoma
#6
Tania Day, Geoff Otton, Ken Jaaback, Julie Weigner, James Scurry
OBJECTIVE: The aim of the study was to assess for the presence of vulvar lichen planus (LP) in association with human papillomavirus (HPV)-independent squamous cell carcinoma (SCC). MATERIALS AND METHODS: We performed a clinicohistopathologic review of consecutive vulvectomies and wide local excisions for HPV-independent vulvar or vaginal SCC from 2007 to 2017. Data collected included site of SCC, adjacent precursor lesions and dermatoses, dermatologic treatment, and outcome...
February 22, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29470167/role-of-race-ethnicity-language-and-insurance-in-use-of-cervical-cancer-prevention-services-among-low-income-hispanic-women-2009-2013
#7
John Heintzman, Brigit Hatch, Gloria Coronado, David Ezekiel, Stuart Cowburn, Octavio Escamilla-Sanchez, Miguel Marino
INTRODUCTION: Hispanic women in the United States have an elevated risk of cervical cancer, but the existing literature does not reveal why this disparity persists. METHODS: We performed a retrospective cohort analysis of 17,828 low-income women aged 21 to 64 years seeking care at Oregon community health centers served by a hosted, linked electronic health record during 2009 through 2013. We assessed the odds of having had Papanicolaou (Pap) tests and receiving human papillomavirus (HPV) vaccine, by race/ethnicity, insurance status, and language...
February 22, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29470166/what-drives-health-professionals-to-tweet-about-hpvvaccine-identifying-strategies-for-effective-communication
#8
Philip M Massey, Alex Budenz, Amy Leader, Kara Fisher, Ann C Klassen, Elad Yom-Tov
INTRODUCTION: We conducted this study to quantify how health professionals use Twitter to communicate about the human papillomavirus (HPV) vaccine. METHODS: We collected 193,379 tweets from August 2014 through July 2015 that contained key words related to HPV vaccine. We classified all tweets on the basis of user, audience, sentiment, content, and vaccine characteristic to examine 3 groups of tweets: 1) those sent by health professionals, 2) those intended for parents, and 3) those sent by health professionals and intended for parents...
February 22, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29470122/a-qualitative-comparative-analysis-of-combined-state-health-policies-related-to-human-papillomavirus-vaccine-uptake-in-the-united-states
#9
Megan C Roberts, Taylor Murphy, Jennifer L Moss, Christopher W Wheldon, Wayne Psek
OBJECTIVES: To examine how combinations of state policies, rather than single policies, are related to uptake of human papillomavirus (HPV) vaccine. METHODS: Using publicly available records and the literature, we characterized policies for each US state and Washington, DC, in 2015 (n = 51), including (1) Medicaid expansion, (2) policies permitting HPV vaccination in pharmacies, (3) school-entry requirements, (4) classroom sex education mandates, and (5) parental education mandates...
February 22, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29469687/diverse-papillomaviruses-identified-in-weddell-seals
#10
Zoe E Smeele, Jennifer M Burns, Koenraad Van Doorsaler, Rafaela S Fontenele, Kara Waits, Daisy Stainton, Michelle R Shero, Roxanne S Beltran, Amy L Kirkham, Rachel Berngartt, Simona Kraberger, Arvind Varsani
Papillomaviridae is a diverse family of circular, double-stranded DNA (dsDNA) viruses that infect a broad range of mammalian, avian and fish hosts. While papillomaviruses have been characterized most extensively in humans, the study of non-human papillomaviruses has contributed greatly to our understanding of their pathogenicity and evolution. Using high-throughput sequencing approaches, we identified 7 novel papillomaviruses from vaginal swabs collected from 81 adult female Weddell seals (Leptonychotes weddellii) in the Ross Sea of Antarctica between 2014-2017...
February 22, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29468855/major-clinical-research-advances-in-gynecologic-cancer-in-2017
#11
REVIEW
Dong Hoon Suh, Miseon Kim, Kyung Hun Lee, Keun Yong Eom, Maj Kamille Kjeldsen, Mansoor Raza Mirza, Jae Weon Kim
In 2017, 10 topics were selected as major clinical research advances in gynecologic oncology. For cervical cancer, efficacy and safety analysis results of a 9-valent human papillomavirus (HPV) vaccine and long-term impact of reduced dose of quadrivalent vaccine were updated. Brief introduction of KEYNOTE trials of pembrolizumab, a monoclonal antibody that blocks the interaction between programmed death (PD)-1 and its ligands, PD-L1 and PD-L2, followed. Tailored surveillance programs for gynecologic cancer related with Lynch syndrome and update on sentinel lymph node mapping were reviewed for uterine corpus cancer...
March 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29468275/-the-innate-immune-system-in-oropharyngeal-squamous-cell-carcinoma-immune-modulation-by-hpv
#12
REVIEW
S Wagner, H Böckmann, S Gattenlöhner, J P Klussmann, C Wittekindt
Based on clinical and experimental data, oropharyngeal squamous cell carcinomas (OPSCC) associated with human papillomavirus (HPV) have been recognized as a distinct entity of head and neck cancers. However, outside of clinical trials, HPV status currently has no impact on treatment. The natural replication cycle of HPV takes place in epithelial cells, and is thus spatially separated from cytotoxic immune cells in the epidermis. Dendritic cells (Langerhans cells, LC), however, are frequent in this upper dermal layer...
February 15, 2018: HNO
https://www.readbyqxmd.com/read/29468136/retinoic-acid-receptor-beta-promoter-methylation-and-risk-of-cervical-cancer
#13
REVIEW
Chaninya Wongwarangkana, Nasamon Wanlapakorn, Jira Chansaenroj, Yong Poovorawan
Cervical cancer is one of the leading causes of death in women worldwide, particularly in developing countries. Human papillomavirus has been reported as one of the key etiologic factors in cervical carcinoma. Likewise, epigenetic aberrations have ability to regulate cancer pathogenesis and progression. Recent research suggested that methylation has been detected already at precancerous stages, which methylation markers may have significant value in cervical cancer screening. The retinoic acid receptor beta ( RAR β) gene, a potential tumor suppressor gene, is usually expressed in normal epithelial tissue...
February 12, 2018: World Journal of Virology
https://www.readbyqxmd.com/read/29468081/progressive-cutaneous-viral-pigmented-plaques-in-three-hungarian-vizslas-and-the-response-of-lesions-to-topical-tigilanol-tiglate-gel
#14
Naomi Hansen, Nikianna Nicholas, Graeme Pack, John T Mackie, Michael Shipstone, John S Munday, Paul Reddell, Geoff Orbell, Richard Malik
Cutaneous pigmented viral plaques is a disorder of epidermal growth caused by canine papillomavirus type 4 (CPV-4). There is currently no standard of care for managing this condition and it has not been reported in the Hungarian Vizsla. This case series documents the clinical features of canine pigmented viral plaques in Hungarian Vizsla dogs and the treatment of a severe case using a novel topical agent tigilanol tiglate (EBC-46). A 4-year-old spayed Hungarian Vizsla in Australia was presented for multiple cutaneous pigmented plaques extending from the ventral cervical region...
February 2018: Veterinary Medicine and Science
https://www.readbyqxmd.com/read/29467931/toll-like-receptor-2-induces-adenosine-receptor-a2a-and-promotes-human-squamous-carcinoma-cell-growth-via-extracellular-signal-regulated-kinases-%C3%A2
#15
Chithra Devi Palani, Lalitha Ramanathapuram, Aroonwan Lam-Ubol, Zoya B Kurago
Patient treatment for oral squamous cell carcinoma (OSCC) not associated with Human papillomavirus remains problematic. OSCC microenvironment is typically inflamed and colonized by microorganisms, providing ligands for toll-like receptors (TLR). In immune cells TLR2 and TLR4 activate NF-kB and extracellular signal regulated kinase (ERK)1/2 pathways, leading to upregulation of inhibitory adenosine receptors A2a and A2b, and reduction in stimulatory A1 and A3. How TLR and adenosine receptors function in SCC cells is not understood...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29467726/mitochondrial-proteins-coded-by-human-tumor-viruses
#16
REVIEW
Ilaria Cavallari, Gloria Scattolin, Micol Silic-Benussi, Vittoria Raimondi, Donna M D'Agostino, Vincenzo Ciminale
Viruses must exploit the cellular biosynthetic machinery and evade cellular defense systems to complete their life cycles. Due to their crucial roles in cellular bioenergetics, apoptosis, innate immunity and redox balance, mitochondria are important functional targets of many viruses, including tumor viruses. The present review describes the interactions between mitochondria and proteins coded by the human tumor viruses human T-cell leukemia virus type 1, Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus, human hepatitis viruses B and C, and human papillomavirus, and highlights how these interactions contribute to viral replication, persistence and transformation...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29466435/separate-analysis-of-human-papillomavirus-e6-and-e7-messenger-rnas-to-predict-cervical-neoplasia-progression
#17
Shuling Liu, Takeo Minaguchi, Bouchra Lachkar, Shuang Zhang, Chenyang Xu, Yuri Tenjimbayashi, Ayumi Shikama, Nobutaka Tasaka, Azusa Akiyama, Manabu Sakurai, Sari Nakao, Hiroyuki Ochi, Mamiko Onuki, Koji Matsumoto, Hiroyuki Yoshikawa, Toyomi Satoh
A few studies previously suggested that human papillomavirus (HPV) E6 messenger RNA (mRNA) may exist uniformly in all grades of cervical intraepithelial neoplasia (CIN), whereas the detection rate of E7 mRNA may increase with disease progression from low-grade CIN to invasive carcinoma. The aim of this study was to clarify the different roles of E6 and E7 mRNAs in cervical carcinogenesis. The presence of each E6 and E7 mRNA was analyzed in 171 patients with pathologically-diagnosed CIN or cervical carcinoma...
2018: PloS One
https://www.readbyqxmd.com/read/29466255/differential-expression-of-micrornas-in-uterine-cervical-cancer-and-its-implications-in-carcinogenesis-an-integrative-approach
#18
Veena B Nair, V G Manasa, M S Sinto, K Jayasree, Francis V James, S Kannan
OBJECTIVES: Cervical cancer is the second most common cancer in women in developing countries, including India. Recently, microRNAs (miRNAs) are gaining importance in cancer biology because of their involvement in various cellular processes. The present study aimed to profile miRNA expression pattern in cervical cancer, identify their target genes, and understand their role in carcinogenesis. METHODS: Human papillomavirus (HPV) infection statuses in samples were assessed by heminested polymerase chain reaction followed by direct DNA sequencing...
March 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29465832/human-papillomavirus-and-immunosuppressive-drugs-in-dermatology-a-neoplastic-combination
#19
A O Olsen
No abstract text is available yet for this article.
February 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29465701/optimizing-screening-for-sexually-transmitted-infections-in-men-using-self-collected-swabs-a-systematic-review
#20
Nicholas Yared, Keith Horvath, Oluwaseun Fashanu, Ran Zhao, Jason Baker, Shalini Kulasingam
BACKGROUND: Sexually transmitted infection (STI) rates are increasing in the U.S. while funding for prevention and treatment programs has declined. Sample self-collection for STI testing in men may provide an acceptable, easy, rapid and potentially cost-effective method for increasing diagnosis and treatment of STIs. METHODS: We conducted a systematic review of articles assessing self-collection of anal, oral, or genital swab samples among adult men for detection of STIs and/or human papillomavirus (HPV)-related dysplasia...
October 6, 2017: Sexually Transmitted Diseases
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