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https://www.readbyqxmd.com/read/29907115/determinants-of-human-papillomavirus-vaccine-attitudes-an-interview-of-wisconsin-parents
#1
Kathrine L Barnes, Jeffrey J VanWormer, Shannon Stokley, Elizabeth R Vickers, Huong Q McLean, Edward A Belongia, Casper G Bendixsen
BACKGROUND: Parental attitudes play a key role in their decisions to vaccinate adolescents against the human papillomavirus (HPV). Little is known, however, about the formative experiences that shape parents' attitudes about the HPV vaccine. METHODS: We conducted semi-structured interviews with 25 parents of 11-17 year old adolescents in Wisconsin who changed their HPV vaccine attitudes (per prior surveys) over one year. A modified grounded theory approach was then used to generate primary themes of attitudinal determinants...
June 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29906660/prevalence-of-cervical-oral-and-anal-human-papillomavirus-infection-in-women-living-with-hiv-in-denmark-the-shade-cohort-study
#2
Kristina Thorsteinsson, Merete Storgaard, Terese L Katzenstein, Steen Ladelund, Frederikke F Rönsholt, Isik Somuncu Johansen, Gitte Pedersen, Anne Gaardsting, Lars Nørregård Nielsen, Jesper Bonde, Anne-Mette Lebech
BACKGROUND: Women living with HIV (WLWH) have elevated risk of human papillomavirus (HPV) related cancers. OBJECTIVES: To assess prevalence, distribution and concordance of cervical, oral, and anal HPV infection, and predictors of oral and anal HPV in WLWH in Denmark. STUDY DESIGN: WLWH followed in the Study on HIV, cervical Abnormalities and infections in women in Denmark (SHADE) were enrolled and examined for cervical, oral, and anal HPV infection...
May 25, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29906593/evaluation-of-self-collected-vaginal-specimens-for-the-detection-of-high-risk-hpv-infection-and-the-prediction-of-high-grade-cervical-intraepithelial-lesions-in-a-high-burden-low-resource-setting
#3
P J Toliman, J M Kaldor, S G Badman, S Phillips, G Tan, J M L Brotherton, M Saville, A J Vallely, S N Tabrizi
OBJECTIVES: To compare the performance of self-collected vaginal (V) specimens with clinician-collected cervical (C) specimens for detection of high-risk human papillomavirus (hrHPV) and cervical disease using the Cepheid Xpert HPV, Roche Cobas 4800 HPV, and Hologic Aptima HPV assays. METHODS: Women aged 30-59 years (N=1005) were recruited at two clinics in Papua New Guinea, and provided specimens for testing at point-of-care using the Xpert HPV Test, and for subsequent testing using the Cobas HPV (n=981) and Aptima HPV (n=983) assays...
June 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29905865/impact-of-naturally-occurring-variation-in-the-human-papillomavirus-hpv-58-capsid-proteins-on-recognition-by-type-specific-neutralizing-antibodies
#4
Anna Godi, Marianna Martinelli, Mahmoud Haque, Shaowei Li, Qinjian Zhao, Ningshao Xia, Clementina E Cocuzza, Simon Beddows
Background: Naturally-occurring variants of Human papillomavirus (HPV) 58 have been defined as lineages and sublineages but little is known about the impact of this diversity on protein function. We investigate the impact of variation within the major (L1) and minor (L2) capsid proteins of HPV58 on susceptibility to neutralizing antibodies. Methods: Pseudovirus (PsV) representing A1, A2, A3, B1, B2, C, D1 and D2 variants were evaluated for their susceptibility to antibodies elicited during natural infection, preclinical antisera generated against virus-like particles and monoclonal antibodies (MAbs)...
June 13, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29905354/-hpv-a-different-view-on-head-and-neck-cancer
#5
Claus Wittekindt, Steffen Wagner, Shachi Jenny Sharma, Nora Würdemann, Jennifer Knuth, Henrike Reder, Jens Peter Klußmann
Head and neck cancer is the sixth most common cancer with over 500000 annually reported incident cases worldwide. Besides major risk factors tobacco and alcohol, oropharyngeal squamous cell carcinomas (OSCC) show increased association with human papillomavirus (HPV). HPV-associated and HPV-negative OSCC are 2 different entities regarding biological characteristics, therapeutic response, and patient prognosis. In HPV OSCC, viral oncoprotein activity, as well as genetic (mutations and chromosomal aberrations) and epigenetic alterations plays a key role during carcinogenesis...
March 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29905313/prevalence-and-risk-factors-for-genital-human-papillomavirus-infections-among-women-in-southwest-nigeria
#6
Y T Nejo, D O Olaleye, G N Odaibo
There is a great variation in the prevalence of cervical HPV infection worldwide with some of the highest rates being found in African women. Early onset of sexual activity (≤ 15 age), multiparity and sexual promiscuity have been recognized as some of the significant risk factors for HPV infection. In Nigeria, there is scarcity of data on the degree of relationship between these factors and the prevalence of HPV infection. Thus, this study was designed to determine the prevalence of genital HPV infection with its potential risk factors among women in Southwest Nigeria...
February 2018: Archives of basic and applied medicine
https://www.readbyqxmd.com/read/29904749/barriers-to-hpv-vaccination-among-unvaccinated-haitian-american-college-women
#7
Dudith Pierre-Victor, Dionne P Stephens, Angela Omondi, Rachel Clarke, Naomie Jean-Baptiste, Purnima Madhivanan
Background: Haitian women residing in the United States are disproportionately affected by cervical cancer. Human papillomavirus (HPV) vaccine has been licensed in the United States since 2006. Vaccination rates are less than optimal overall, and the rates are particularly low among young black women. We investigated barriers to HPV vaccination in a sample of Haitian American college women. Methods: Thirty self-identified Haitian American women, aged 17-26 years, were recruited from a large university campus in southeastern United States ( n =30)...
2018: Health Equity
https://www.readbyqxmd.com/read/29904122/molecular-identification-of-papillomavirus-in-ducks
#8
Richard A J Williams, Conny Tolf, Jonas Waldenström
Papillomaviruses infect many vertebrates, including birds. Persistent infections by some strains can cause malignant proliferation of cells (i.e. cancer), though more typically infections cause benign tumours, or may be completely subclinical. Sometimes extensive, persistent tumours are recorded-notably in chaffinches and humans. In 2016, a novel papillomavirus genotype was characterized from a duck faecal microbiome, in Bhopal, India; the sixth papillomavirus genotype from birds. Prompted by this finding, we screened 160 cloacal swabs and 968 faecal samples collected from 299 ducks sampled at Ottenby Bird Observatory, Sweden in 2015, using a newly designed real-time PCR...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29903818/two-novel-distantly-related-papillomaviruses-isolated-from-healthy-skin-of-the-timor-deer-rusa-timorensis
#9
Beatriz Mengual-Chuliá, Gudrun Wibbelt, Marc Gottschling, Ignacio G Bravo
We report the complete genome sequences of Rusa timorensis papillomavirus 1 (RtimPV1) and Rusa timorensis papillomavirus 2 (RtimPV2), isolated from hair follicles of asymptomatic skin from the same Timor deer specimen. RtimPV1 and RtimPV2 are evolutionarily only distantly related. RtimPV1 lacks a canonical E2-binding site, and RtimPV2 does not carry an E6 gene.
June 14, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29903744/parents-views-on-the-best-and-worst-reasons-for-guideline-consistent-hpv-vaccination
#10
Melissa B Gilkey, Mo Zhou, Annie-Laurie McRee, Melanie L Kornides, John F P Bridges
Background: Human papillomavirus (HPV) vaccination could prevent most HPV-associated cancers, but few U.S. adolescents are vaccinated according to guidelines. To inform efforts to counsel parents more effectively, we sought to quantify their views on the best and worst reasons for guideline-consistent HPV vaccination. We hypothesized that parents' views would differ according to their vaccination confidence. Methods: We developed a best-worst scaling experiment to evaluate 11 reasons healthcare providers commonly give for HPV vaccination...
June 14, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29902979/topical-imiquimod-treatment-of-residual-or-recurrent-cervical-intraepithelial-neoplasia-topic-2-trial-a-study-protocol-for-a-randomized-controlled-trial
#11
A J M van de Sande, M M Koeneman, C G Gerestein, A J Kruse, F J van Kemenade, H J van Beekhuizen
BACKGROUND: Cervical dysplasia (cervical intraepithelial neoplasia (CIN)) is caused by Human Papillomavirus (HPV) and is most common in women of reproductive age. Current treatment of moderate to severe CIN is surgical. This procedure has potential complications, such as haemorrhage, infection and preterm birth in subsequent pregnancies. Moreover, 15% of women treated for high grade CIN develop residual/recurrent CIN or cervical cancer after surgical excision. Finally, 75-100% of patients with a residual and recurrent CIN 2-3 lesion are still HPV positive...
June 15, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29902519/the-association-between-sexually-transmitted-infections-human-papillomavirus-and-cervical-cytology-abnormalities-among-women-in-greece
#12
Christos Parthenis, Periklis Panagopoulos, Niki Margari, Christine Kottaridi, Aris Spathis, Abraham Pouliakis, Stefanos Konstantoudakis, George Chrelias, Charalambos Chrelias, Nikolaos Papantoniou, Ioannis G Panayiotides, Sotirios Tsiodras
OBJECTIVES: To investigate STIs diagnosis with HPV infection and the presence of cytological changes of the cervix in a cohort of sexually active women in Greece. METHODS: Cervical cytology testing, molecular typing of HPV and other STIs was performed in 345 sexually active women aged between 18 and 45 years (33.2±7.2) visiting a gynaecology clinic for routine cervical screening. We investigated the association of HPV and STI detection with cytological findings...
June 11, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29902477/development-of-a-vaginal-fast-dissolving-insert-combining-griffithsin-and-carrageenan-for-potential-use-against-sexually-transmitted-infections
#13
Manjari Lal, Manshun Lai, Shweta Ugaonkar, Asa Wesenberg, Larisa Kizima, Aixa Rodriguez, Keith Levendosky, Olga Mizenina, José Fernández-Romero, Thomas Zydowsky
Precoital, on-demand topical microbicides to reduce a woman's risk of sexually transmitted infections have been in development for nearly three decades, but no product has been approved due to acceptability issues and poor adherence in clinical trials. We set out to develop a self-administered vaginal fast-dissolving insert (FDI) produced by freeze-drying that would deliver safe and effective amounts of the antiviral agents griffithsin (GRFT) and carrageenan (CG) and would have properties women and their partners find acceptable...
June 11, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29901522/expression-of-markers-of-m%C3%A3-llerian-clear-cell-carcinoma-in-primary-cervical-and-vaginal-gastric-type-adenocarcinomas
#14
Karen L Talia, Richard Wing-Cheuk Wong, W Glenn McCluggage
The incidence of cervical adenocarcinoma, both absolute and relative to squamous cell carcinoma, is increasing. Most cervical adenocarcinomas are human papillomavirus associated, although non-human papillomavirus-associated neoplasms exist; the latter include gastric-type adenocarcinoma (GAS) and clear cell carcinoma (CCC). Histologically, these 2 tumors may superficially resemble one other and although morphologic evaluation usually permits a correct diagnosis, immunohistochemistry may be required to resolve diagnostic uncertainty, especially in a small biopsy specimen...
June 12, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29901456/a-comparative-study-of-two-techniques-in-the-treatment-of-condyloma-acuminata
#15
M Fevzi Celayir, Kinyas Kartal, Mehmet Mihmanli
OBJECTIVES: Condyloma acuminata (CA) is mainly caused by human papillomavirus (HPV) types 6 and 11. Clinicians use many different methods to treat analcondyloma acuminate ( CA). In this study, we aimed to compare electrocautery ablation (ECA) and argon plasma coagulation (APC) techniques in terms of postoperative bleeding, pain, scar development, loss of sexual sensation, and recurrence rates. METHODS: A retrospective analysis of collected data was performed for 49consecutive patients with CA, who underwent surgery between July 2011 and July 2014...
June 14, 2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29901186/early-synergistic-interactions-between-the-hpv16%C3%A2-e7-oncoprotein-and-17%C3%AE-oestradiol-for-repressing-the-expression-of-granzyme-b-in-a-cervical-cancer-model
#16
J Antonio Munguía-Moreno, José Díaz-Chavéz, Enrique García-Villa, M Estela Albino-Sanchez, Daniel Mendoza-Villanueva, Rodolfo Ocadiz-Delgado, José Bonilla-Delgado, Armando Marín-Flores, Enoc M Cortés-Malagón, Elizabeth Alvarez-Rios, Alfredo Hidalgo-Miranda, Aykut Üren, Haydar Çelik, Paul F Lambert, Patricio Gariglio
Although high-risk human papillomavirus (HR‑HPV) infection has a prominent role in the aetiology of cervical cancer (CC), sex steroid hormones may also be involved in this process; however, the cooperation between oestrogen and HR‑HPV in the early stages of cervical carcinogenesis is poorly understood. Since 17β-oestradiol (E2) and the HPV type 16‑E7 oncoprotein induce CC in transgenic mice, a microarray analysis was performed in the present study to generate global gene expression profiles from 2‑month‑old FVB (non‑transgenic) and K14E7 (transgenic) mice who were left untreated or were treated for 1 month with E2...
June 6, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29899842/high-throughput-testing-in-head-and-neck-squamous-cell-carcinoma-identifies-agents-with-preferential-activity-in-human-papillomavirus-positive-or-negative-cell-lines
#17
Farhad Ghasemi, Morgan Black, Ren X Sun, Frederick Vizeacoumar, Nicole Pinto, Kara M Ruicci, John Yoo, Kevin Fung, Danielle MacNeil, David A Palma, Eric Winquist, Joe S Mymryk, Laurie A Ailles, Alessandro Datti, John W Barrett, Paul C Boutros, Anthony C Nichols
Head and neck squamous cell carcinoma (HNSCC) is a common cancer diagnosis worldwide. Despite advances in treatment, HNSCC has very poor survival outcomes, emphasizing an ongoing need for development of improved therapeutic options. The distinct tumor characteristics of human papillomavirus (HPV)-positive vs . HPV-negative disease necessitate development of treatment strategies tailored to tumor HPV-status. High-throughput robotic screening of 1,433 biologically and pharmacologically relevant compounds at a single dose (4 μM) was carried out against 6 HPV-positive and 20 HPV-negative HNSCC cell lines for preliminary identification of therapeutically relevant compounds...
May 25, 2018: Oncotarget
https://www.readbyqxmd.com/read/29898441/atypical-squamous-cells-cytopathological-findings-and-correlation-with-hpv-genotype-and-histopathology
#18
Geilson Gomes de Oliveira, Judite Maria da Silva Costa de Oliveira, Renata Mirian Nunes Eleutério, Rita de Cássia Carvalho Barbosa, Paulo Roberto Carvalho de Almeida, José Eleutério
OBJECTIVE: We aimed to assess potential associations between atypical squamous cell (ASC) subgroups: ASC-US (undetermined significance) and ASC-H (cannot exclude high-grade squamous intraepithelial lesion), regarding cytomorphological features, high-risk (HR) human papillomavirus (HPV) testing, and histological outcomes in a sample of Brazilian women. STUDY DESIGN: Cross-sectional study which evaluated 1,346 liquid-based cytologies between January 2010 and July 2016 with ASC results...
June 13, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29898433/electrochemotherapy-with-cisplatin-or-bleomycin-in-head-and-neck-squamous-cell-carcinoma-improved-effectiveness-of-cisplatin-in-hpv-positive-tumors
#19
Ajda Prevc, Martina Niksic Zakelj, Simona Kranjc, Maja Cemazar, Janez Scancar, Tina Kosjek, Primoz Strojan, Gregor Sersa
Human papillomavirus (HPV) is an important etiological factor in head and neck squamous cell carcinomas (SCCs). Standard treatment of HPV-positive tumors with platinum-based radio(chemo)therapy results in a better outcome than in HPV-negative tumors. Electrochemotherapy is becoming an increasingly recognized mode of treatment in different cancers; thus, its use in the management of head and neck SCC is of considerable interest. However, response to electrochemotherapy according to HPV status of the tumors has not been evaluated yet...
June 6, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29896305/ultrahigh-resolution-optical-coherence-microscopy-accurately-classifies-precancerous-and-cancerous-human-cervix-free-of-labeling
#20
Xianxu Zeng, Xiaoan Zhang, Canyu Li, Xiaofang Wang, Jason Jerwick, Tao Xu, Yuan Ning, Yihong Wang, Linlin Zhang, Zhan Zhang, Yutao Ma, Chao Zhou
Cervical cancer remains the fourth most common cause of cancer worldwide and the third leading cause of cancer deaths for women in developing countries. Traditional screening tools, such as human papillomavirus and Pap tests, cannot provide results in real-time and cannot localize suspicious regions. Colposcopy-directed biopsies are invasive in nature and only a few sites of the cervix may be chosen for investigation. A non-invasive, label-free and real-time imaging method with a resolution approaching that of histopathology is desirable for early detection of the disease...
2018: Theranostics
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