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Animal assisted disease therapy

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https://www.readbyqxmd.com/read/28993949/poly-n-methylated-a%C3%AE-peptide-c-terminal-fragments-meptides-reverse-the-deleterious-effects-of-amyloid-%C3%AE-in-rats
#1
Siya G Sibiya, Musa V Mbandla, Thavi Govender, Adeola Shobo, William M U Daniels
Alzheimer's disease (AD) is characterized by extracellular deposition of amyloid-β (Aβ) plaques. These protein deposits impair synaptic plasticity thereby producing a progressive decline in cognitive function. Current therapies are merely palliative and only slow cognitive decline. Poly-N-methylated Aβ-Peptide C-Terminal Fragments (MEPTIDES) were recently shown to reduce Aβ toxicity in vitro and in Drosophila melanogaster, however whether these novel compounds are effective in inhibiting Aβ-induced toxicity in the mammalian brain remains unclear...
October 9, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28699394/stepping-out-of-the-shadows-of-alzheimer-s-disease-a-phenomenological-hermeneutic-study-of-older-people-with-alzheimer-s-disease-caring-for-a-therapy-dog
#2
Anna Swall, Britt Ebbeskog, Carina Lundh Hagelin, Ingegerd Fagerberg
PURPOSE: Living with Alzheimer's disease (AD) can involve a person being unable to recall and convey information in daily life. There are several ways to provide person-centred care to older people with AD, e.g. by empowering them in a situation. The use of animal-assisted therapy (AAT) with a therapy dog in the care of people with dementia is increasing, with the presence of a therapy dog being described as improving, among other things, the well-being and socialization of the person...
December 2017: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/28660769/platelets-as-a-surrogate-disease-model-of-neurodevelopmental-disorders-insights-from-fragile-x-syndrome
#3
David Pellerin, Audrey Lortie, François Corbin
Fragile X Syndrome (FXS) is the most common inherited form of intellectual disability and the leading monogenic cause of autism spectrum disorders (ASD). Despite a large number of therapeutics developed in past years, there is currently no targeted treatment approved for FXS. In fact, translation of the positive and very promising preclinical findings from animal models to human subjects has so far fallen short owing in part to the low predictive validity of the Fmr1 ko mouse, an overly simplistic model of the complex human disease...
June 29, 2017: Platelets
https://www.readbyqxmd.com/read/28629387/an-updated-assessment-of-microglia-depletion-current-concepts-and-future-directions
#4
REVIEW
Jinming Han, Robert A Harris, Xing-Mei Zhang
Microglia are the principal resident immune cells in the central nervous system and are believed to be versatile players in both inflammatory and physiological contexts. On the one hand, in order to safeguard the microenvironment microglia can be rapidly activated by contact with microbial products or cell debris, thereby exerting the functions of innate immunity via phagocytosis and secretion of cytokines and chemokines. Conversely, microglia can also assist in brain development, synaptic plasticity and neural repair through the production of neurotrophic factors and clearance of myelin debris...
June 19, 2017: Molecular Brain
https://www.readbyqxmd.com/read/28606809/animal-derived-natural-products-of-sowa-rigpa-medicine-their-pharmacopoeial-description-current-utilization-and-zoological-identification
#5
Karma Yeshi, Paolo Morisco, Phurpa Wangchuk
ETHNOPHARMACOLOGICAL RELEVANCE: The Bhutanese Sowa Rigpa medicine (BSM) uses animal parts in the preparation of numerous polyingredient traditional remedies. Our study reports the taxonomical identification of medicinal animals and the description of traditional uses in English medical terminologies. AIM OF THE STUDY: To taxonomically identify the medicinal animals and their derived natural products used as a zootherapeutic agents in BSM. MATERIALS AND METHODS: First, the traditional textbooks were reviewed to generate a list of animal products described as ingredients...
June 9, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28592637/in-vivo-imaging-of-prodromal-hippocampus-ca1-subfield-oxidative-stress-in-models-of-alzheimer-disease-and-angelman-syndrome
#6
Bruce A Berkowitz, Jacob Lenning, Nikita Khetarpal, Catherine Tran, Johnny Y Wu, Ali M Berri, Kristin Dernay, E Mark Haacke, Fatema Shafie-Khorassani, Robert H Podolsky, John C Gant, Shaniya Maimaiti, Olivier Thibault, Geoffrey G Murphy, Brian M Bennett, Robin Roberts
Hippocampus oxidative stress is considered pathogenic in neurodegenerative diseases, such as Alzheimer disease (AD), and in neurodevelopmental disorders, such as Angelman syndrome (AS). Yet clinical benefits of antioxidant treatment for these diseases remain unclear because conventional imaging methods are unable to guide management of therapies in specific hippocampus subfields in vivo that underlie abnormal behavior. Excessive production of paramagnetic free radicals in nonhippocampus brain tissue can be measured in vivo as a greater-than-normal 1/T1 that is quenchable with antioxidant as measured by quench-assisted (Quest) MRI...
September 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28533045/-evaluation-of-the-animal-assisted-therapy-in-alzheimer-s-disease
#7
RANDOMIZED CONTROLLED TRIAL
Clémence Quibel, Marie Bonin, Magalie Bonnet, Maryse Gaimard, France Mourey, Isabelle Moesch, Pierre Ancet
Animal-assisted therapy sessions have been set up in a protected unit for patients with a dementia-related syndrome. The aim is to measure the effects of animal-assisted therapy on behavioural disorders in daily life and care. The results obtained provided some interesting areas to explore and recommendations with a view to optimising the implementation of such a system.
May 2017: Soins. Gérontologie
https://www.readbyqxmd.com/read/28398242/drug-induced-liver-injury-can-biomarkers-assist-rucam-in-causality-assessment
#8
REVIEW
Rolf Teschke, Johannes Schulze, Axel Eickhoff, Gaby Danan
Drug induced liver injury (DILI) is a potentially serious adverse reaction in a few susceptible individuals under therapy by various drugs. Health care professionals facing DILI are confronted with a wealth of drug-unrelated liver diseases with high incidence and prevalence rates, which can confound the DILI diagnosis. Searching for alternative causes is a key element of RUCAM (Roussel Uclaf Causality Assessment Method) to assess rigorously causality in suspected DILI cases. Diagnostic biomarkers as blood tests would be a great help to clinicians, regulators, and pharmaceutical industry would be more comfortable if, in addition to RUCAM, causality of DILI can be confirmed...
April 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28357477/wnt5a-is-elevated-in-heart-failure-and-affects-cardiac-fibroblast-function
#9
Aurelija Abraityte, Leif E Vinge, Erik T Askevold, Tove Lekva, Annika E Michelsen, Trine Ranheim, Katrine Alfsnes, Arnt Fiane, Svend Aakhus, Ida G Lunde, Christen P Dahl, Pål Aukrust, Geir Christensen, Lars Gullestad, Arne Yndestad, Thor Ueland
Wnt signaling is dysregulated in heart failure (HF) and may promote cardiac hypertrophy, fibrosis, and inflammation. Blocking the Wnt ligand Wnt5a prevents HF in animal models. However, the role of Wnt5a in human HF and its functions in cardiac cells remain unclear. Here, we investigated Wnt5a regulation in HF patients and its effects on primary mouse and human cardiac fibroblasts. Serum Wnt5a was elevated in HF patients and associated with hemodynamic, neurohormonal, and clinical measures of disease severity...
July 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28298263/a-proof-of-principle-simulation-for-closed-loop-control-based-on-preexisting-experimental-thalamic-dbs-enhanced-instrumental-learning
#10
Ching-Fu Wang, Shih-Hung Yang, Sheng-Huang Lin, Po-Chuan Chen, Yu-Chun Lo, Han-Chi Pan, Hsin-Yi Lai, Lun-De Liao, Hui-Ching Lin, Hsu-Yan Chen, Wei-Chen Huang, Wun-Jhu Huang, You-Yin Chen
Deep brain stimulation (DBS) has been applied as an effective therapy for treating Parkinson's disease or essential tremor. Several open-loop DBS control strategies have been developed for clinical experiments, but they are limited by short battery life and inefficient therapy. Therefore, many closed-loop DBS control systems have been designed to tackle these problems by automatically adjusting the stimulation parameters via feedback from neural signals, which has been reported to reduce the power consumption...
May 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28286105/animal-models-in-idiopathic-inflammatory-myopathies-how-to-overcome-a-translational-roadblock
#11
REVIEW
Ali Maisam Afzali, Tobias Ruck, Heinz Wiendl, Sven G Meuth
Idiopathic inflammatory myopathies (IIMs) encompass a heterogenic group of rare muscle diseases with common symptoms including muscle weakness and the presence of certain histological features. Since the pathogenesis remains unclear, therapeutic approaches in general comprise unspecific immunosuppression strategies that have been met with limited success. Therefore, a deeper understanding of the underlying pathophysiological mechanisms is critically required to assist in development of targeted therapies. Animal models have proven to be tremendously helpful in mechanistic studies and allow researchers to overcome the inevitable restrictions of human research...
May 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28241882/systematic-review-of-patient-factors-affecting-adipose-stem-cell-viability-and-function-implications-for-regenerative-therapy
#12
REVIEW
Jajini Varghese, Michelle Griffin, Afshin Mosahebi, Peter Butler
BACKGROUND: The applications for fat grafting have increased recently, within both regenerative and reconstructive surgery. Although fat harvesting, processing and injection techniques have been extensively studied and standardised, this has not had a big impact on the variability of outcome following fat grafting. This suggests a possible larger role of patient characteristics on adipocyte and adipose-derived stem cell (ADSC) viability and function. This systematic review aims to collate current evidence on the effect of patient factors on adipocyte and ADSC behaviour...
February 28, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28147365/measurement-of-fibrosis-in-crohn-s-disease-strictures-with-imaging-and-blood-biomarkers-to-inform-clinical-decisions
#13
REVIEW
Peter D R Higgins
BACKGROUND: Distinguishing fibrosis from inflammation in an intestinal stricture in Crohn's disease is quite difficult. The absence of signs of inflammation on CT or MRI does not prove the absence of inflammation, as most strictures have a mix of fibrosis and inflammation. Identifying refractory fibrosis and distinguishing the patients who will respond to anti-inflammatory therapy from those who will require surgery are important clinical requirements, and several new technologies in imaging and serum biomarkers are being applied to this problem...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28018848/mitochondrial-transfer-implications-for-assisted-reproductive-technologies
#14
REVIEW
A S Reznichenko, C Huyser, M S Pepper
The use of mitochondrial transfer as a clinic procedure is drawing closer to reality. Here we provide a detailed overview of mitochondrial transfer techniques - both established and recent - including pronuclear, spindle, ooplasmic and blastomere transfer. Reasons as to why some techniques are more suitable for the prevention of mitochondrial DNA disease than others, as well as the advantages and disadvantages of each methodology, are discussed. The possible clinical introduction of these techniques has raised concerns about the adverse effects they may have on resultant embryos and offspring...
December 2016: Applied & Translational Genomics
https://www.readbyqxmd.com/read/27959442/lung-cancer-gene-therapy-transferrin-and-hyaluronic-acid-dual-ligand-decorated-novel-lipid-carriers-for-targeted-gene-delivery
#15
Bin Zhang, Yueying Zhang, Dongmei Yu
To achieve lung cancer gene therapy, nanocarriers decorated with different ligands were used. Surface decoration and nanoparticulate system will assist in targeting the gene to specific cells and tissues, such as cancers and diseased organs. The aim of this research was to develop a dual ligand-decorated nanocarriers, which could target the tumor cells through receptor-mediated pathways to increase the uptake of genetic materials. Transferrin (Tf) and hyaluronic (HA) containing polyethylene glycol-distearoylphosphatidylethanolamine (Tf-PEG-DSPE and HA-PEG-DSPE) ligands were synthesized...
February 2017: Oncology Reports
https://www.readbyqxmd.com/read/27810365/treatment-of-parkinson-s-disease-in-rats-by-nrf2-transfection-using-mri-guided-focused-ultrasound-delivery-of-nanomicrobubbles
#16
Ling Long, Xiaodong Cai, Ruomi Guo, Ping Wang, Lili Wu, Tinghui Yin, Siyuan Liao, Zhengqi Lu
Parkinson's disease (PD) is a very common neurological disorder. However, effective therapy is lacking. Although the blood-brain-barrier (BBB) protects the brain, it prevents the delivery of about 90% of drugs and nucleotides into the brain, thereby hindering the development of gene therapy for PD. Magnetic resonance imaging (MRI)-guided focused ultrasound delivery of microbubbles enhances the delivery of gene therapy vectors across the BBB and improves transfection efficiency. In the present study, we delivered nuclear factor E2-related factor 2 (Nrf2, NFE2L2) contained in nanomicrobubbles into the substantia nigra of PD rats by MRI-guided focused ultrasound, and we examined the effect of Nrf2 over-expression in this animal model of PD...
January 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27667178/improvement-of-vascular-function-by-magnetic-nanoparticle-assisted-circumferential-gene-transfer-into-the-native-endothelium
#17
Sarah Vosen, Sarah Rieck, Alexandra Heidsieck, Olga Mykhaylyk, Katrin Zimmermann, Christian Plank, Bernhard Gleich, Alexander Pfeifer, Bernd K Fleischmann, Daniela Wenzel
Gene therapy is a promising approach for chronic disorders that require continuous treatment such as cardiovascular disease. Overexpression of vasoprotective genes has generated encouraging results in animal models, but not in clinical trials. One major problem in humans is the delivery of sufficient amounts of genetic vectors to the endothelium which is impeded by blood flow, whereas prolonged stop-flow conditions impose the risk of ischemia. In the current study we have therefore developed a strategy for the efficient circumferential lentiviral gene transfer in the native endothelium under constant flow conditions...
November 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27609634/online-cardiac-output-estimation-during-transvalvular-left-ventricular-assistance
#18
Daniel Rüschen, Miriam Rimke, Jonas Gesenhues, Steffen Leonhardt, Marian Walter
BACKGROUND AND OBJECTIVES: Sufficient cardiac output is one of the main goals of ventricular assist device therapy. To date, there is no adequate method to estimate the combined amount of blood the native heart and a continuous-flow assist device pump through the circulatory system. This paper presents an approach to estimate total cardiac output based on the signals provided by optical pressure sensors mounted on the inlet and outlet of an Abiomed Impella CP pump. METHODS: Two Kalman filters were used in parallel for joint estimation of the aortic flow rate and the hydraulic resistance of the aortic valve...
August 30, 2016: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/27439773/stem-cell-based-therapies-for-ischemic-stroke-preclinical-results-and-the-potential-of-imaging-assisted-evaluation-of-donor-cell-fate-and-mechanisms-of-brain-regeneration
#19
REVIEW
Pascal Gervois, Esther Wolfs, Jessica Ratajczak, Yörg Dillen, Tim Vangansewinkel, Petra Hilkens, Annelies Bronckaers, Ivo Lambrichts, Tom Struys
Stroke is the second most common cause of death and is a major cause of permanent disability. Given the current demographic trend of an ageing population and associated increased risk, the prevalence of and socioeconomic burden caused by stroke will continue to rise. Current therapies are unable to sufficiently ameliorate the disease outcome and are not applicable to all patients. Therefore, strategies such as cell-based therapies with mesenchymal stem cell (MSC) or induced pluripotent stem cell (iPSC) pave the way for new treatment options for stroke...
November 2016: Medicinal Research Reviews
https://www.readbyqxmd.com/read/27383855/tickborne-coinfections-in-the-united-states
#20
REVIEW
James H Diaz
Unlike mosquitoes, ticks transmit the broadest range of pathogens, including bacteria, viruses, and parasites. Ticks have capitalized on many competitive advantages offered to them by changes in climate and human lifestyle and a greater abundance of wild animal reservoir hosts no longer effectively controlled. As a result, tick-transmitted coinfections are increasing today with both recognized and newly discovered pathogens that complicate differential diagnosis and antimicrobial treatment. Without the support of immunological and molecular diagnostic techniques, usually only available at federal and some state laboratories, the initial differential diagnosis of tickborne coinfections is complicated and antimicrobial therapy may not cover coinfections...
March 2016: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
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