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Animal assisted disease therapy

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https://www.readbyqxmd.com/read/27810365/treatment-of-parkinson-s-disease-in-rats-by-nrf2-transfection-using-mri-guided-focused-ultrasound-delivery-of-nanomicrobubbles
#1
Ling Long, Xiaodong Cai, Ruomi Guo, Ping Wang, Lili Wu, Tinghui Yin, Siyuan Liao, Zhengqi Lu
Parkinson's disease (PD) is a very common neurological disorder. However, effective therapy is lacking. Although the blood-brain-barrier (BBB) protects the brain, it prevents the delivery of about 90% of drugs and nucleotides into the brain, thereby hindering the development of gene therapy for PD. Magnetic resonance imaging (MRI)-guided focused ultrasound delivery of microbubbles enhances the delivery of gene therapy vectors across the BBB and improves transfection efficiency. In the present study, we delivered nuclear factor E2-related factor 2 (Nrf2, NFE2L2) contained in nanomicrobubbles into the substantia nigra of PD rats by MRI-guided focused ultrasound, and we examined the effect of Nrf2 over-expression in this animal model of PD...
October 31, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27667178/improvement-of-vascular-function-by-magnetic-nanoparticle-assisted-circumferential-gene-transfer-into-the-native-endothelium
#2
Sarah Vosen, Sarah Rieck, Alexandra Heidsieck, Olga Mykhaylyk, Katrin Zimmermann, Christian Plank, Bernhard Gleich, Alexander Pfeifer, Bernd K Fleischmann, Daniela Wenzel
Gene therapy is a promising approach for chronic disorders that require continuous treatment such as cardiovascular disease. Overexpression of vasoprotective genes has generated encouraging results in animal models, but not in clinical trials. One major problem in humans is the delivery of sufficient amounts of genetic vectors to the endothelium which is impeded by blood flow, whereas prolonged stop-flow conditions impose the risk of ischemia. In the current study we have therefore developed a strategy for the efficient circumferential lentiviral gene transfer in the native endothelium under constant flow conditions...
November 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27609634/online-cardiac-output-estimation-during-transvalvular-left-ventricular-assistance
#3
Daniel Rüschen, Miriam Rimke, Jonas Gesenhues, Steffen Leonhardt, Marian Walter
BACKGROUND AND OBJECTIVES: Sufficient cardiac output is one of the main goals of ventricular assist device therapy. To date, there is no adequate method to estimate the combined amount of blood the native heart and a continuous-flow assist device pump through the circulatory system. This paper presents an approach to estimate total cardiac output based on the signals provided by optical pressure sensors mounted on the inlet and outlet of an Abiomed Impella CP pump. METHODS: Two Kalman filters were used in parallel for joint estimation of the aortic flow rate and the hydraulic resistance of the aortic valve...
August 30, 2016: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/27439773/stem-cell-based-therapies-for-ischemic-stroke-preclinical-results-and-the-potential-of-imaging-assisted-evaluation-of-donor-cell-fate-and-mechanisms-of-brain-regeneration
#4
Pascal Gervois, Esther Wolfs, Jessica Ratajczak, Yörg Dillen, Tim Vangansewinkel, Petra Hilkens, Annelies Bronckaers, Ivo Lambrichts, Tom Struys
Stroke is the second most common cause of death and is a major cause of permanent disability. Given the current demographic trend of an ageing population and associated increased risk, the prevalence of and socioeconomic burden caused by stroke will continue to rise. Current therapies are unable to sufficiently ameliorate the disease outcome and are not applicable to all patients. Therefore, strategies such as cell-based therapies with mesenchymal stem cell (MSC) or induced pluripotent stem cell (iPSC) pave the way for new treatment options for stroke...
July 21, 2016: Medicinal Research Reviews
https://www.readbyqxmd.com/read/27383855/tickborne-coinfections-in-the-united-states
#5
James H Diaz
Unlike mosquitoes, ticks transmit the broadest range of pathogens, including bacteria, viruses, and parasites. Ticks have capitalized on many competitive advantages offered to them by changes in climate and human lifestyle and a greater abundance of wild animal reservoir hosts no longer effectively controlled. As a result, tick-transmitted coinfections are increasing today with both recognized and newly discovered pathogens that complicate differential diagnosis and antimicrobial treatment. Without the support of immunological and molecular diagnostic techniques, usually only available at federal and some state laboratories, the initial differential diagnosis of tickborne coinfections is complicated and antimicrobial therapy may not cover coinfections...
March 2016: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27314367/diet-before-and-during-pregnancy-and-offspring-health-the-importance-of-animal-models-and-what-can-be-learned-from-them
#6
Pascale Chavatte-Palmer, Anne Tarrade, Delphine Rousseau-Ralliard
This review article outlines epidemiologic studies that support the hypothesis that maternal environment (including early nutrition) plays a seminal role in determining the offspring's long-term health and metabolism, known as the concept of Developmental Origins of Health and Diseases (DOHaD). In this context, current concerns are particularly focused on the increased incidence of obesity and diabetes, particularly in youth and women of child-bearing age. We summarize key similarities, differences and limitations of various animal models used to study fetal programming, with a particular focus on placentation, which is critical for translating animal findings to humans...
2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27279073/protective-effects-of-bmscs-in-combination-with-erythropoietin-in-bronchopulmonary-dysplasia-induced-lung-injury
#7
Zhao-Hua Zhang, Yan-Yan Pan, Rui-Sheng Jing, Yun Luan, Luan Zhang, Chao Sun, Feng Kong, Kai-Lin Li, Yi-Biao Wang
Bronchopulmonary dysplasia (BPD) is the most common type of chronic lung disease in infancy, for which no effective therapy is currently available. The aim of the present study was to investigate the effect of treatment with bone marrow mesenchymal stem cells (BMSCs) in combination with recombinant human erythropoietin (rHuEPO) on BPD‑induced mouse lung injury, and discuss the underlying mechanism. The BPD model was established by the exposure of neonatal mice to continuous high oxygen exposure for 14 days, following which 1x106 BMSCs and 5,000 U/kg rHuEPO were injected into the mice 1 h prior to and 7 days following exposure to hyperoxia...
August 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27138773/tickborne-coinfections-in-the-united-states
#8
James H Diaz Md
Unlike mosquitoes, ticks transmit the broadest range of pathogens, including bacteria, viruses, and parasites. Ticks have capitalized on many competitive advantages offered to them by changes in climate and human lifestyle and a greater abundance of wild animal reservoir hosts no longer effectively controlled. As a result, tick-transmitted coinfections are increasing today with both recognized and newly discovered pathogens that complicate differential diagnosis and antimicrobial treatment. Without the support of immunological and molecular diagnostic techniques, usually only available at federal and some state laboratories, the initial differential diagnosis of tickborne coinfections is complicated and antimicrobial therapy may not cover coinfections...
March 2016: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27101372/diplomatic-assistance-can-helminth-modulated-macrophages-act-as-treatment-for-inflammatory-disease
#9
REVIEW
Svenja Steinfelder, Noëlle Louise O'Regan, Susanne Hartmann
Helminths have evolved numerous pathways to prevent their expulsion or elimination from the host to ensure long-term survival. During infection, they target numerous host cells, including macrophages, to induce an alternatively activated phenotype, which aids elimination of infection, tissue repair, and wound healing. Multiple animal-based studies have demonstrated a significant reduction or complete reversal of disease by helminth infection, treatment with helminth products, or helminth-modulated macrophages in models of allergy, autoimmunity, and sepsis...
April 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/26933042/strategies-and-challenges-to-myocardial-replacement-therapy
#10
REVIEW
Nicole T Feric, Milica Radisic
UNLABELLED: Cardiovascular diseases account for the majority of deaths globally and are a significant drain on economic resources. Although heart transplants and left-ventricle assist devices are the solution for some, the best chance for many patients who suffer because of a myocardial infarction, heart failure, or a congenital heart disease may be cell-based regenerative therapies. Such therapies can be divided into two categories: the application of a cell suspension and the implantation of an in vitro engineered tissue construct to the damaged area of the heart...
April 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/26861550/preclinical-models-of-muscle-spasticity-valuable-tools-in-the-development-of-novel-treatment-for-neurological-diseases-and-conditions
#11
Anton Bespalov, Liudmila Mus, Edwin Zvartau
Poor validity of preclinical animal models is one of the most commonly discussed explanations for the failures to develop novel drugs in general and in neuroscience in particular. However, there are several areas of neuroscience such as injury-induced spasticity where etiological factor can be adequately recreated and models can focus on specific pathophysiological mechanisms that likely contribute to spasticity syndrome in humans (such as motoneuron hyperexcitability and spinal hyperreflexia). Methods used to study spasticity in preclinical models are expected to have a high translational value (e...
May 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/26621335/an-unexpected-cause-for-cavitary-pneumonia-and-empyema
#12
Constantine Bloch-Infanger, Katarzyna Furrer, Mark Wiese, Andreas Hiebinger, Christoph M Bucher, Sébastien Kopp, Vladimira Hinić, Daniel Goldenberger
Tularemia is an emerging zoonotic disease mainly of the Northern Hemisphere caused by the Gram-negative coccobacillus Francisella tularensis. It is affecting a wide range of animals and causes human disease after insect and tick bites, skin contact, ingestion and inhalation. A 66-year-old man presented to our clinic with cavitary pneumonia and distinct pleural effusion. After failure of empiric antibiotic therapy, thoracoscopic assisted decortication and partial excision of the middle lobe were conducted. Conventional culture methods and broad-range bacterial PCR including RipSeqMixed analysis were performed from the excised biopsies...
August 2016: Infection
https://www.readbyqxmd.com/read/26598385/effectiveness-of-practices-to-increase-timeliness-of-providing-targeted-therapy-for-inpatients-with-bloodstream-infections-a-laboratory-medicine-best-practices-systematic-review-and-meta-analysis
#13
REVIEW
Stephanie S Buehler, Bereneice Madison, Susan R Snyder, James H Derzon, Nancy E Cornish, Michael A Saubolle, Alice S Weissfeld, Melvin P Weinstein, Edward B Liebow, Donna M Wolk
BACKGROUND: Bloodstream infection (BSI) is a major cause of morbidity and mortality throughout the world. Rapid identification of bloodstream pathogens is a laboratory practice that supports strategies for rapid transition to direct targeted therapy by providing for timely and effective patient care. In fact, the more rapidly that appropriate antimicrobials are prescribed, the lower the mortality for patients with sepsis. Rapid identification methods may have multiple positive impacts on patient outcomes, including reductions in mortality, morbidity, hospital lengths of stay, and antibiotic use...
January 2016: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/26374176/nutritional-impact-of-dietary-plasma-proteins-in-animals-undergoing-experimental-challenge-and-implications-for-patients-with-inflammatory-bowel-disorders-a-meta-analysis
#14
REVIEW
Ramana Kuchibhatla, Bryon W Petschow, Jack Odle, Eric M Weaver
Studies administering plasma protein isolates (PPIs) to experimentally challenged animals have reported improvements in growth, food intake, and overall condition when compared with animals fed control diets, due in part to improvements in gut barrier function, normalization of cytokine signals, and support of enteric immune function. These and early clinical studies suggest that nutritional therapy with PPIs may similarly assist in restoring homeostasis to gut barrier function in humans experiencing mild or more acute enteropathic symptomatology such as irritable bowel syndrome and inflammatory bowel disease...
September 2015: Advances in Nutrition
https://www.readbyqxmd.com/read/26370064/evaluation-of-the-efficacy-of-animal-assisted-therapy-based-on-the-reality-orientation-therapy-protocol-in-alzheimer-s-disease-patients-a-pilot-study
#15
Lucia Francesca Menna, Antonio Santaniello, Federica Gerardi, Annamaria Di Maggio, Graziella Milan
BACKGROUND: The aim of this study was to evaluate the efficacy of animal-assisted therapy (AAT) in elderly patients affected by Alzheimer's disease based on the formal reality orientation therapy (ROT) protocol. METHODS: Our study was carried out at an Alzheimer's centre for 6 months. A homogeneous sample (age, Mini-Mental State Examination (MMSE), 15-item Geriatric Depression Scale (GDS)) of 50 patients was selected at random and successively. Patients were divided into three groups: (i) 20 patients received a course of AAT (AAT group) based on the ROT protocol; (ii) 20 patients were engaged exclusively in activities based on the ROT group; and (iii) 10 patients (control group) participated in no stimulations...
July 2016: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/26292453/the-role-and-impact-of-animals-with-pediatric-patients
#16
REVIEW
Anna Tielsch Goddard, Mary Jo Gilmer
Animal-facilitated therapy (AFT), more specifically known as animal-assisted therapy (AAT) or "pet therapy," has had an increased presence in the literature with a surge of recent research methodologies exploring this complementary alternative medicine (CAM) intervention. However, limited studies have been conducted in the pediatric population, with many articles anecdotal in nature. A literature review included primary data sources PubMed, PsychINFO, Medline, and CINAHL, and yielded positive and beneficial outcomes to be gained through AAT in the pediatric population...
March 2015: Pediatric Nursing
https://www.readbyqxmd.com/read/26245278/il-17-sequestration-via-salivary-gland-gene-therapy-in-a-mouse-model-of-sjogren-s-syndrome-suppresses-disease-associated-expression-of-the-putative-autoantigen-klk1b22
#17
Changgong Wu, Zhimin Wang, Lee Zourelias, Hiteshi Thakker, Michael J Passineau
INTRODUCTION: IL-17 has a putative role in the pathophysiology of Sjogren's syndrome (SS) and has been shown to be upregulated in the salivary glands of affected individuals. Sequestration of IL-17 with Adenoviral-mediated gene therapy has previously shown a benefit upon the SS-like phenotype in the Aec1/Aec2 mouse model. We sought to understand the proteomic consequences of IL-17 sequestration in the salivary gland of this mouse model as a means of illuminating the role of IL-17 in SS-like disease...
2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/26189434/corynebacterium-ulcerans-cutaneous-diphtheria
#18
REVIEW
Luke S P Moore, Asuka Leslie, Margie Meltzer, Ann Sandison, Androulla Efstratiou, Shiranee Sriskandan
We describe the case of a patient with cutaneous diphtheria caused by toxigenic Corynebacterium ulcerans who developed a right hand flexor sheath infection and symptoms of sepsis such as fever, tachycardia, and elevated C-reactive protein, after contact with domestic cats and dogs, and a fox. We summarise the epidemiology, clinical presentation, microbiology, diagnosis, therapy, and public health aspects of this disease, with emphasis on improving recognition. In many European countries, C ulcerans has become the organism commonly associated with cutaneous diphtheria, usually seen as an imported tropical disease or resulting from contact with domestic and agricultural animals...
September 2015: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/26125041/differential-involvement-of-ras-grf1-and-ras-grf2-in-l-dopa-induced-dyskinesia
#19
Simone Bido, Nicola Solari, Marzia Indrigo, Angela D'Antoni, Riccardo Brambilla, Michele Morari, Stefania Fasano
OBJECTIVE: Recent findings have shown that pharmacogenetic manipulations of the Ras-ERK pathway provide a therapeutic means to tackle l-3,4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia (LID). First, we investigated whether a prolonged l-DOPA treatment differentially affected ERK signaling in medium spiny neurons of the direct pathway (dMSNs) and in cholinergic aspiny interneurons (ChIs) and assessed the role of Ras-GRF1 in both subpopulations. Second, using viral-assisted technology, we probed Ras-GRF1 and Ras-GRF2 as potential targets in this pathway...
June 2015: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/26088192/biomaterials-as-carrier-barrier-and-reactor-for-cell-based-regenerative-medicine
#20
REVIEW
Chunxiao Qi, Xiaojun Yan, Chenyu Huang, Alexander Melerzanov, Yanan Du
Cell therapy has achieved tremendous success in regenerative medicine in the past several decades. However, challenges such as cell loss, death and immune-rejection after transplantation still persist. Biomaterials have been designed as carriers to deliver cells to desirable region for local tissue regeneration; as barriers to protect transplanted cells from host immune attack; or as reactors to stimulate host cell recruitment, homing and differentiation. With the assistance of biomaterials, improvement in treatment efficiency has been demonstrated in numerous animal models of degenerative diseases compared with routine free cell-based therapy...
September 2015: Protein & Cell
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