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https://www.readbyqxmd.com/read/27919862/spinal-cord-injury-assessing-tolerability-and-use-of-combined-rehabilitation-and-neuroaid-saturn-study-protocol-of-an-exploratory-study-in-assessing-the-safety-and-efficacy-of-neuroaid-amongst-people-who-sustain-severe-spinal-cord-injury
#1
Ramesh Kumar, Ohnmar Htwe, Azmi Baharudin, Mohammad Hisam Ariffin, Shaharuddin Abdul Rhani, Kamalnizat Ibrahim, Aishah Rustam, Robert Gan
BACKGROUND: Spinal cord injury (SCI) is a devastating condition with limited therapeutic options despite decades of research. Current treatment options include use of steroids, surgery, and rehabilitation. Nevertheless, many patients with SCI remain disabled. MLC601 (NeuroAiD), a combination of natural products, has been shown to be safe and to aid neurological recovery after brain injuries and may have a potential role in improving recovery after SCI. OBJECTIVE: The aim of this study is to evaluate the safety and efficacy of NeuroAiD amongst people who sustain SCI in the study setting...
December 5, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27914473/effectiveness-of-enhanced-cognitive-behavioral-therapy-cbt-e-for-eating-disorders-study-protocol-for-a-randomized-controlled-trial
#2
Martie de Jong, Kees Korrelboom, Iris van der Meer, Mathijs Deen, Hans W Hoek, Philip Spinhoven
BACKGROUND: While eating disorder not otherwise specified (EDNOS) is the most common eating disorder (ED) diagnosis in routine clinical practice, no specific treatment methods for this diagnosis have yet been developed and studied. Enhanced cognitive behavioral therapy (CBT-E) has been described and put to the test as a transdiagnostic treatment protocol for all EDs, including EDNOS. Initial research in the UK suggests that CBT-E is more effective for EDs, especially bulimia nervosa (BN) and EDNOS, than the earlier version of CBT...
December 3, 2016: Trials
https://www.readbyqxmd.com/read/27914469/predicting-general-and-cancer-related-distress-in-women-with-newly-diagnosed-breast-cancer
#3
Andrea Gibbons, AnnMarie Groarke, Karl Sweeney
BACKGROUND: Psychological distress can impact medical outcomes such as recovery from surgery and experience of side effects during treatment. Identifying the factors that explain variability in distress would guide future interventions aimed at decreasing distress. Two factors that have been implicated in distress are illness perceptions and coping, and are part of the Self-Regulatory Model of Illness Behaviour (SRM). The model suggests that coping mediates the relationship between illness perceptions and distress...
December 3, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27912934/effect-of-sequential-treatment-with-tcm-syndrome-differentiation-on-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-and-aecopd-risk-window
#4
Li Jiansheng, Wang Haifeng, Li Suyun, Zhang Hailong, Yu Xueqing, Zhang Xiaoyun, Li Fengsen, Zhou Xianmei, Sun Zikai, Mao Yimin, Ma Lijun, Zhang Yijie, Zhang Guojun, Tang Bingxiang
OBJECTIVE: To evaluate the efficacy and safety of the comprehensive interventions based on three Traditional Chinese medicine (TCM) patterns therapy in acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and AECOPD risk window. METHODS: A prospective, multi-center, single-blinded, double-dummy and randomized controlled clinical trial is being conducted to test the therapeutic effects of a sequential two stage treatment. A total of 364 patients were enrolled into this study with 182 in each treatment group (TCM and conventional)...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27912920/the-relationship-between-therapist-rated-function-and-patient-reported-outcome-measures
#5
Yvonne Braun, Jos J Mellema, Rinne M Peters, Suzanne Curley, Gae Burchill, David Ring
STUDY DESIGN: Prospective cohort study. INTRODUCTION: Some third-party payers require hand therapists to rate patient's functional disability based on patient self-rating using patient-reported outcome measures (PROMs), objective measurements of impairment, and observation of functional tasks-hand therapist-rated function (HTRF). PURPOSE OF THE STUDY: To test the correlation between HTRF and PROMs (upper limb functional index [ULFI] and Patient-Reported Outcomes Measurement Information System upper extremity [PROMIS UE]) and its association with psychological factors...
November 29, 2016: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/27911915/marathon-race-affects-neutrophil-surface-molecules-role-of-inflammatory-mediators
#6
Vinicius Coneglian Santos, Ana Paula Renno Sierra, Rodrigo Oliveira, Kim Guimarães Caçula, César Miguel Momesso, Fabio Takeo Sato, Maysa Braga Barros Silva, Heloisa Helena Oliveira, Maria Elizabeth Pereira Passos, Diego Ribeiro de Souza, Olivia Santos Gondim, Marino Benetti, Adriana Cristina Levada-Pires, Nabil Ghorayeb, Maria Augusta Peduti Dal Molin Kiss, Renata Gorjão, Tânia Cristina Pithon-Curi, Maria Fernanda Cury-Boaventura
The fatigue induced by marathon races was observed in terms of inflammatory and immunological outcomes. Neutrophil survival and activation are essential for inflammation resolution and contributes directly to the pathogenesis of many infectious and inflammatory conditions. The aim of this study was to investigate the effect of marathon races on surface molecules related to neutrophil adhesion and extrinsic apoptosis pathway and its association with inflammatory markers. We evaluated 23 trained male runners at the São Paulo International Marathon 2013...
2016: PloS One
https://www.readbyqxmd.com/read/27907194/preservation-of-multiple-mammalian-tissues-to-maximize-science-return-from-ground-based-and-spaceflight-experiments
#7
Sungshin Choi, Hami E Ray, San-Huei Lai, Joshua S Alwood, Ruth K Globus
BACKGROUND: Even with recent scientific advancements, challenges posed by limited resources and capabilities at the time of sample dissection continue to limit the collection of high quality tissues from experiments that can be conducted only infrequently and at high cost, such as in space. The resources and time it takes to harvest tissues post-euthanasia, and the methods and duration of long duration storage, potentially have negative impacts on sample quantity and quality, thereby limiting the scientific outcome that can be achieved...
2016: PloS One
https://www.readbyqxmd.com/read/27905390/-pr%C3%B0-gnosis-of-motor-function-recovery-in-ischemic-stroke-using-diffusion-tensor-mri
#8
M Yu Maksimova, T A Popova, R N Konovalov
AIM: To identify factors of motor recovery in ischemic stroke (IS) using diffusion tensor imaging (DTI). MATERIAL AND METHODS: Forty-seven patients with IS were studied within 1-2, 7-8, 14-15, 20-21 days after stroke. The fractional anisotropy (FA) values of the pyramidal tract were measured in the posterior limb of the internal capsule, cerebral peduncle and pons. Relative values of FA (rFA) ratio (rFA=FA affected side/FA unaffected side) were assessed as well...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27904913/statistical-process-control-a-feasibility-study-of-the-application-of-time-series-measurement-in-early-neurorehabilitation-after-acquired-brain-injury
#9
Gabriela Markovic, Marie-Louise Schult, Aniko Bartfai, Mattias Elg
BACKGROUND: Progress in early cognitive recovery after acquired brain injury is uneven and unpredictable, and thus the evaluation of rehabilitation is complex. The use of time-series measurements is susceptible to statistical change due to process variation. OBJECTIVE: To evaluate the feasibility of using a time-series method, statistical process control, in early cognitive rehabilitation. METHOD: Participants were 27 patients with acquired brain injury undergoing interdisciplinary rehabilitation of attention within 4 months post-injury...
November 30, 2016: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27904798/functional-outcomes-after-distal-biceps-brachii-repair-a-case-series
#10
Christine L Redmond, Tim Morris, Charissa Otto, Tanisha Zerella, John G Semmler, Taaibos Human, Joideep Phadnis, Gregory I Bain
OBJECTIVES: To investigate outcomes after surgical repair of distal biceps tendon rupture and the influence of arm dominance on isokinetic flexion and supination results. BACKGROUND/PURPOSE: While relatively uncommon, rupture of the distal biceps tendon can result in significant strength deficits, for which surgical repair is recommended. The purpose of this study was to assess patient reported functional outcomes and muscle performance following surgery. METHODS: A sample of 23 participants (22 males, 1 female), who had previously undergone surgical repair of the distal biceps tendon, were re-examined at a minimum of one year after surgery...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27904719/does-cruciate-retaining-total-knee-arthroplasty-show-better-quadriceps-recovery-than-posterior-stabilized-total-knee-arthroplasty-objective-measurement-with-a-dynamometer-in-102-knees
#11
Kye-Youl Cho, Kang-Il Kim, Sang-Jun Song, Dae-Kyung Bae
BACKGROUND: Cruciate-retaining (CR) prostheses have been considered to produce more physiologic femoral rollback, provide better proprioception, and result in better quadriceps recovery than posterior-stabilized (PS) prostheses after total knee arthroplasty (TKA). However, there are very few studies demonstrating these benefits in an objective manner. We investigated whether CR-TKA could result in (1) better quadriceps recovery; (2) a greater proportion of patients with beyond the preoperative level of recovery; and (3) better clinical outcomes than PS-TKA...
December 2016: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/27903479/cost-effectiveness-analysis-of-the-use-of-a-prophylactic-antibiotic-for-patients-undergoing-lower-limb-amputation-due-to-diabetes-or-vascular-illness-in-colombia
#12
REVIEW
Mateo Ceballos, Luis Esteban Orozco, Carlos Oliver Valderrama, Diana Isabel Londoño, Luz Helena Lugo
BACKGROUND: The use of a prophylactic antibiotic in an amputation surgery is a key element for the successful recovery of the patient. We aim to determine, from the perspective of the Colombian health system, the cost-effectiveness of administering a prophylactic antibiotic among patients undergoing lower limb amputation due to diabetes or vascular illness in Colombia. METHODS: A decision tree was constructed to compare the use and non-use of a prophylactic antibiotic...
November 26, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27903136/outcomes-of-a-psychoeducational-intervention-to-reduce-internalized-stigma-among-psychosocial-rehabilitation-clients
#13
Alicia Lucksted, Amy L Drapalski, Clayton H Brown, Camille Wilson, Melanie Charlotte, Audrina Mullane, Li Juan Fang
OBJECTIVE: This community-based randomized controlled trial was carried out to test the Ending Self-Stigma (ESS) psychoeducational intervention, which is designed to help adults with serious mental illnesses reduce internalization of mental illness stigma and its effects. METHODS: A total of 268 adults from five different mental health programs in Maryland took part. After baseline interview, consenting participants were randomly assigned to the nine-week ESS intervention or a minimally enhanced treatment-as-usual control condition...
December 1, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/27900773/systematic-review-of-immunoglobulin-use-in-paediatric-neurological-and-neurodevelopmental-disorders
#14
REVIEW
Jonathan Gadian, Emma Kirk, Kate Holliday, Ming Lim, Michael Absoud
AIM: A systematic literature review of intravenous immunoglobulin (IVIG) treatment of paediatric neurological conditions was performed to summarize the evidence, provide recommendations, and suggest future research. METHOD: A MEDLINE search for articles reporting on IVIG treatment of paediatric neuroinflammatory, neurodevelopmental, and neurodegenerative conditions published before September 2015, excluding single case reports and those not in English. Owing to heterogeneous outcome measures, meta-analysis was not possible...
November 30, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27900700/platelet-rich-plasma-supplementation-in-arthroscopic-repair-of-full-thickness-rotator-cuff-tears-a-randomized-clinical-trial
#15
R D'Ambrosi, F Palumbo, A Paronzini, V Ragone, R M Facchini
BACKGROUND: Results on the effectiveness of PRP supplementation in arthroscopic rotator cuff repair are conflicting, making it difficult to draw definitive conclusions. METHODS: This was a prospective, randomized, and double-blind study with two groups of 20 patients each (PRP group and control group). Degenerative supraspinatus full-thickness tears grade C2-C3 were subjected to arthroscopic repair; PRP supplementation was given to patients in the PRP group. The outcomes were assessed by DASH, Constant scales, and ultrasound before and 6 months after surgery...
December 2016: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/27900514/process-evaluation-of-a-community-garden-at-an-urban-outpatient-clinic
#16
Brandy-Joe Milliron, Mara Z Vitolins, Elizabeth Gamble, Robert Jones, Margaret C Chenault, Janet A Tooze
In addition to expediting patient recovery, community gardens that are associated with medical facilities can provide fresh produce to patients and their families, serve as a platform for clinic-based nutrition education, and help patients develop new skills and insights that can lead to positive health behavior change. While community gardening is undergoing resurgence, there is a strong need for evaluation studies that employ valid and reliable measures. The objective of this study was to conduct a process evaluation of a community garden program at an urban medical clinic to estimate the prevalence of patient awareness and participation, food security, barriers to participation, and personal characteristics; garden volunteer satisfaction; and clinic staff perspectives in using the garden for patient education/treatment...
November 29, 2016: Journal of Community Health
https://www.readbyqxmd.com/read/27900339/an-ecological-study-of-anterior-cruciate-ligament-reconstruction-part-1-clinical-tests-do-not-correlate-with-return-to-sport-outcomes
#17
Timothy M McGrath, Gordon Waddington, Jennie M Scarvell, Nick Ball, Rob Creer, Kevin Woods, Damian Smith, Roger Adams
BACKGROUND: Additional high-quality prospective studies are needed to better define the objective criteria used in relation to return-to-sport decisions after synthetic (ligament advanced reinforcement system [LARS]) and autograft (hamstring tendon [2ST/2GR]) anterior cruciate ligament (ACL) reconstruction in active populations. PURPOSE: To prospectively investigate and describe the recovery of objective clinical outcomes after autograft (2ST/2GR) and synthetic (LARS) ACL reconstructions, as well as to investigate the relationship between these clinimetric test outcomes and return-to-sport activity (Tegner activity scale [TAS] score) at 12 and 24 months postoperatively...
November 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27898478/inflammatory-mediators-and-pain-in-the-first-year-after-acute-episode-of-low-back-pain-in-elderly-women-longitudinal-data-from-back-complaints-in-the-elders-brazil
#18
Bárbara Zille Queiroz, Daniele Sirineu Pereira, Nayza Maciel de Britto Rosa, Renata Antunes Lopes, André Gustavo Pereira Andrade, Diogo Carvalho Felício, Renata Muniz Freire Vinhal Siqueira Jardim, Amanda Aparecida Oliveira Leopoldino, Juscélio Pereira Silva, Leani Souza Máximo Pereira
OBJECTIVE: The aims of this study were to determine the course of plasma levels of inflammatory mediators (interleukin 6 [IL-6], tumor necrosis factor α [TNF-α], soluble TNF receptor 1 [sTNF-R1]) and the severity of low-back pain (LBP) over 6 to 12 months after an acute episode of LBP in elderly women and to establish an association between inflammatory mediators and LBP recovery. DESIGN: This was a longitudinal study of a subsample (155 elderly women with acute LBP, aged ≥65 years) of the international Back Complaints in the Elders cohort study...
November 24, 2016: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27898439/limiting-sedation-for-patients-with-acute-respiratory-distress-syndrome-time-to-wake-up
#19
Faraaz Ali Shah, Timothy D Girard, Sachin Yende
PURPOSE OF REVIEW: Critically ill patients with acute respiratory distress syndrome (ARDS) may require sedation in their clinical care. The goals of sedation in ARDS patients are to improve patient comfort and tolerance of supportive and therapeutic measures without contributing to adverse outcomes. This review discusses the current evidence for sedation management in patients with ARDS. RECENT FINDINGS: Deep sedation strategies should be avoided in the care of patients with ARDS because deep sedation has been associated with increased time on mechanical ventilation, longer ICU and hospital length of stay, and higher mortality in critically ill patients...
November 24, 2016: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/27898172/association-between-hospital-readmission-and-acute-and-sustained-delays-in-functional-recovery-during-18-months-after-elective-surgery-the-successful-aging-after-elective-surgery-study
#20
Margaret A Pisani, Asha Albuquerque, Edward R Marcantonio, Richard N Jones, Ray Yun Gou, Tamara G Fong, Eva M Schmitt, Douglas Tommet, Ilean I Isaza Aizpurua, David C Alsop, Sharon K Inouye, Thomas G Travison
OBJECTIVES: To examine the effect of hospital readmission on functional recovery after elective surgery in older adults. DESIGN: Prospective cohort of individuals aged 70 and older undergoing elective surgery, enrolled from June 2010 to August 2013. SETTING: Two academic medical centers. PARTICIPANTS: Community-dwelling older adults (N = 566; mean age ± standard deviation 77 ± 5) undergoing major elective surgery and expected to be admitted for at least 3 days...
November 29, 2016: Journal of the American Geriatrics Society
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