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Recovery, outcome, measures

Brian S W Chong, Christopher J Brereton, Alexander Gordon, Joshua S Davis
Background: Pyogenic vertebral osteomyelitis (PVO) is rising in incidence, but optimal methods of investigation and duration of antibiotic therapy remain controversial. Methods: We conducted a single-center retrospective cohort study of PVO at an Australian teaching hospital. We included all adults with a first episode of PVO between 2006 and 2015. PVO was defined based on the presence of prespecified clinical and radiological criteria. The main exposures of interest were investigation strategy and antibiotic treatment...
March 2018: Open Forum Infectious Diseases
Anatole Vilhelm Wiik, Poonam Patel, Joanna Bovis, Adele Cowper, Philip Socrates Pastides, Alison Hulme, Stuart Evans, Charles Stewart
AIM: To determine if ketamine sedation is a safe and cost effective way of treating displaced paediatric radial and ulna fractures in the emergency department. METHODS: Following an agreed interdepartmental protocol, fractures of the radius and ulna (moderately to severely displaced) in children between the age of 2 and 16 years old, presenting within a specified 4 mo period, were manipulated in our paediatric emergency department. Verbal and written consent was obtained prior to procedural sedation to ensure parents were informed and satisfied to have ketamine...
March 18, 2018: World Journal of Orthopedics
Bita Hajian, Jan De Backer, Wim Vos, Wouter H van Geffen, Paul De Winter, Omar Usmani, Tony Cahn, Huib Am Kerstjens, Massimo Pistolesi, Wilfried De Backer
Introduction: Severe exacerbations associated with chronic obstructive pulmonary disease (COPD) that require hospitalization significantly contribute to morbidity and mortality. Definitions for exacerbations are very broad, and it is unclear whether there is one predominant underlying mechanism that leads to them. Functional respiratory imaging (FRI) with modeling provides detailed information about airway resistance, hyperinflation, and ventilation-perfusion (V/Q) mismatch during and following an acute exacerbation...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Carolyn E Wilshire, Tom Kindlon, Robert Courtney, Alem Matthees, David Tuller, Keith Geraghty, Bruce Levin
BACKGROUND: The PACE trial was a well-powered randomised trial designed to examine the efficacy of graded exercise therapy (GET) and cognitive behavioural therapy (CBT) for chronic fatigue syndrome. Reports concluded that both treatments were moderately effective, each leading to recovery in over a fifth of patients. However, the reported analyses did not consistently follow the procedures set out in the published protocol, and it is unclear whether the conclusions are fully justified by the evidence...
March 22, 2018: BMC Psychology
Deok Su Sin, Myoung Hyoun Kim, Soon-Ah Park, Min Cheol Joo, Min Su Kim
Objective: The purpose of this study is to investigate predictors of crossed cerebellar diaschisis (CCD), and the effects of CCD on functional outcomes including motor function, activities of daily living, cognitive function, and ambulation 6 months after onset in patients with intracerebral hemorrhage (ICH). Methods: A total of 74 patients experiencing their first ICH were recruited. If the asymmetric index was more than 10% using single photon emission computed tomography (SPECT), a diagnosis of CCD was confirmed...
February 2018: Annals of Rehabilitation Medicine
Breton M Asken, Russell M Bauer, Kevin M Guskiewicz, Michael A McCrea, Julianne D Schmidt, Christopher C Giza, Aliyah R Snyder, Zachary M Houck, Anthony P Kontos, Thomas W McAllister, Steven P Broglio, James R Clugston, Scott Anderson, Jeff Bazarian, Alison Brooks, Thomas Buckley, Sara Chrisman, Michael Collins, John DiFiori, Stefan Duma, Brian Dykhuizen, James T Eckner, Luis Feigenbaum, April Hoy, Louise Kelly, T Dianne Langford, Laura Lintner, Gerald McGinty, Jason Mihalik, Christopher Miles, Justus Ortega, Nicholas Port, Margot Putukian, Steve Rowson, Steven Svoboda
BACKGROUND: Timely removal from activity after concussion symptoms remains problematic despite heightened awareness. Previous studies indicated potential adverse effects of continuing to participate in physical activity immediately after sustaining a concussion. Hypothesis/Purpose: The purpose was to determine the effect of timing of removal from play after concussion on clinical outcomes. It was hypothesized that immediate removal from activity after sport-related concussion (SRC) would be associated with less time missed from sport, a shorter symptomatic period, and better outcomes on acute clinical measures...
March 1, 2018: American Journal of Sports Medicine
Janet Baack Kukreja, Qiuling Shi, Courtney M Chang, Mohamed A Seif, Brandon M Sterling, Ting-Yu Chen, Kelly M Creel, Ashish M Kamat, Colin P Dinney, Neema Navai, Jay B Shah, Xin Shelley Wang
BACKGROUND: Bladder cancer is a disease of the elderly that is associated with high morbidity in those treated with radical cystectomy. In this observational study of patients with bladder cancer undergoing radical cystectomy, we analyzed and compared patient-reported outcomes from those treated with Enhanced Recovery After Surgery (ERAS) methods versus those who received traditional perioperative care. METHODS: We enrolled patients who underwent radical cystectomy at a high-volume tertiary care referral center from November 2013 to December 2016, when the ERAS concept was being introduced into postoperative care at our institution...
March 1, 2018: Surgical Innovation
Hiroshi Takahashi, Yasuchika Aoki, Arata Nakajima, Masato Sonobe, Fumiaki Terajima, Masahiko Saito, Takuya Miyamoto, Keita Koyama, Keiichiro Yamamoto, Takeo Furuya, Masao Koda, Seiji Ohtori, Masashi Yamazaki, Koichi Nakagawa
PURPOSE: To determine levels of biomarkers reflecting damage to axon, myelin, astrocytes, and neuron in cerebrospinal fluid (CSF) of patients with cervical compression myelopathy. METHODS: We collected 69 CSF samples from patients before spinal surgery for acutely worsening compression myelopathy (AM, 20), chronic compression myelopathy (CM, 20), and lumbar canal stenosis (LCS 29; control). We measured levels of phosphorylated neurofilament subunit H (pNF-H), tau (reflecting axonal damage), myelin basic protein (MBP) (reflecting demyelination), S100b (reflecting astrocyte damage), and neuron-specific enolase (NSE) (reflecting neuronal damage)...
March 19, 2018: European Spine Journal
Ariel Jaitovich, Esther Barreiro
Skeletal muscle dysfunction occurs in COPD patients and affects both ventilatory and non-ventilatory muscle groups. It represents a very important comorbidity that associates with poor quality of life and reduced survival, and results from a complex combination of functional, metabolic and anatomical alterations leading to suboptimal muscle work. Muscle atrophy, altered fiber type and metabolism and chest wall remodeling -in the case of the respiratory muscles- are relevant etiologic contributors to this process...
March 19, 2018: American Journal of Respiratory and Critical Care Medicine
Seung Min Lee, Han Jo Kwon, Sung Who Park, Ji Eun Lee, Ik Soo Byon
PURPOSE: To investigate the difference in choroidal hyperpermeability (CH) assessed using digital fundus camera (DFC) and scanning laser ophthalmoscope (SLO) and its effect on photodynamic therapy (PDT) outcomes in chronic central serous chorioretinopathy. METHODS: Midphase indocyanine green angiography (ICGA) images were acquired using both DFC and SLO in 38 consecutive eyes with chronic central serous chorioretinopathy in this retrospective study. Scanning laser ophthalmoscope-ICGA was taken immediately after DFC-ICGA...
March 16, 2018: Retina
Luís Augusto Arana, Mariana Bolzani Bach, Gustavo Vedana, Mathias Alexandre Volkmann, Jayme Arana
PURPOSE: To describe a case of acute bilateral transient myopia, retinal folds, and island of choroidal delay associated with oral administration of Cefalium, a medication commonly prescribed in Brazil for migraine that combines acetaminophen 500 mg, caffeine 40 mg, dihydroergotamine mesylate 1 mg, and metoclopramide hydrochloride 10 mg. METHODS: A 21-year-old woman with bilateral blurred vision 1 day after the use of Cefalium. The main outcomes measures were BCVA, ocular fundus, ocular coherence tomography, and angiography findings...
April 2018: Retinal Cases & Brief Reports
J B Seeger, J P Schikschneit, C Schuld, R Rupp, M Rickert, A Jahnke, G S Maier, M Clarius
BACKGROUND: Unicompartmental knee arthroplasty (UKA) is an effective treatment for patients with medial osteoarthritis of the knee joint. Instrumented gait analysis provides an objective measure to quantify and qualify postoperative changes of gait. The purpose of this study was to evaluate standardized instrumented gait analysis for functional recovery and gait as an outcome of mobile-bearing UKA in patients with medial osteoarthritis of the knee. METHODS: Twenty-one patients with isolated medial osteoarthritis of the knee joint received mobile-bearing UKA...
March 15, 2018: Knee
Mark M Lowis, Jennifer Harrison, Steve Wiland
Mental health and substance use disorders co-occur frequently, and are associated with poorer outcomes in life domains including housing, employment, health, and recovery. Finding evidence-based interventions for engagement and recovery can be a challenge for practitioners and organizations, as it involves accepting new interventions, and then implementing and measuring the results. However, practitioners frequently use their opinions or non-generalizable experiences rather than evidence-based findings to guide their practice...
March 16, 2018: Community Mental Health Journal
Julia Pietilä, Elina Helander, Ilkka Korhonen, Tero Myllymäki, Urho M Kujala, Harri Lindholm
BACKGROUND: Sleep is fundamental for good health, and poor sleep has been associated with negative health outcomes. Alcohol consumption is a universal health behavior associated with poor sleep. In controlled laboratory studies, alcohol intake has been shown to alter physiology and disturb sleep homeostasis and architecture. The association between acute alcohol intake and physiological changes has not yet been studied in noncontrolled real-world settings. OBJECTIVE: The aim of this study was to assess the effects of alcohol intake on the autonomic nervous system (ANS) during sleep in a large noncontrolled sample of Finnish employees...
March 16, 2018: JMIR Mental Health
Alex Y Lo, Shuwen Liu
Many high-density cities struggle to find space for disposing municipal solid waste. Hong Kong is one of these cities, seeking to scale up waste recovery efforts as an alternative to disposal. However, territory-wide recovery initiatives do not account for socio-economic variations across place, leading to mixed outcomes among diverse communities. This study aims to investigate socio-economic effects on recycling behavior in a sample of subsidized rental housing estates. It constitutes an improvement from previous studies by using the entire estate as a unit of analysis and analyzing actual recycling outcomes, which have received limited attention from researchers...
March 13, 2018: Journal of Environmental Management
Anao Zhang, QingYing Ji, Jennifer Currin-McCulloch, Phyllis Solomon, YuTing Chen, Yaxi Li, Barbara Jones, Cynthia Franklin, Jack Nowicki
PURPOSE: Given the critical role of parental care for pediatric cancer patients, this pilot study evaluated the feasibility and effectiveness of a hospital-based solution-focused brief therapy (SFBT) intervention for reducing psychological distress among parents of pediatric cancer patients in China. Differences between treatment and active control (AC) groups were assessed on dimensions of psychological distress. Parents' level of hope was also assessed. METHODS: Participants (N = 44) were randomly assigned to SFBT or AC...
March 15, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Emily Andrew, Eric Mercier, Ziad Nehme, Stephen Bernard, Karen Smith
INTRODUCTION: Understanding the prognosis of elderly out-of-hospital cardiac arrest (OHCA) patients is vital to informing resuscitation and advanced care planning decisions. However, short-term outcomes such as survival to hospital discharge do not account for post-arrest quality of life. We describe the 12-month functional recovery and health-related quality of life (HR-QOL) of elderly OHCA survivors, including those arresting in aged care facilities. METHODS: We conducted a retrospective analysis of Victorian Ambulance Cardiac Arrest Registry data for all OHCA survivors to hospital discharge aged ≥65 years between 1 January 2010 and 30 June 2016...
March 12, 2018: Resuscitation
Til Wykes, Eileen Joyce, Tjasa Velikonja, Andrew Watson, Gregory Aarons, Max Birchwood, Matteo Cella, Sue Dopson, David Fowler, Kathy Greenwood, Sonia Johnson, Paul McCrone, Jesus Perez, Andrew Pickles, Clare Reeder, Diana Rose, Swaran Singh, Dominic Stringer, Matthew Taylor, Rumina Taylor, Rachel Upthegrove
BACKGROUND: Cognitive problems in people with schizophrenia predict poor functional recovery even with the best possible rehabilitation opportunities and optimal medication. A psychological treatment known as cognitive remediation therapy (CRT) aims to improve cognition in neuropsychiatric disorders, with the ultimate goal of improving functional recovery. Studies suggest that intervening early in the course of the disorder will have the most benefit, so this study will be based in early intervention services, which treat individuals in the first few years following the onset of the disorder...
March 15, 2018: Trials
Débora Finger, Fábio Juner Lanferdini, Juliano Boufleur Farinha, Clarissa Müller Brusco, Lucas Helal, Francesco Pinto Boeno, Eduardo Lusa Cadore, Ronei Silveira Pinto
INTRODUCTION: Protein (PRO) combined with a carbohydrate (CHO) beverage may have an ergogenic effect on endurance performance. However, evidence regarding its efficacy on similar conditions to athletes' race day is still lacking. OBJECTIVE: To compare the effect of three different nutritional supplementation strategies on performance and muscle recovery in a duathlon protocol. METHODS: , 13 male athletes (29.7 ± 7.7 years) participated in three simulated Olympic-distance duathlons under three different, randomly assigned, supplementation regimens: carbohydrate drink (CHO, 75 g); isocaloric CHO plus protein drink (CHO+PRO, 60...
March 15, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Jahan Heidari, Jürgen Beckmann, Maurizio Bertollo, Michel Brink, Wolfgang Kallus, Claudio Robazza, Michael Kellmann
Monitoring of recovery in the context of athletic performance has gained significant importance during recent years. As a systematic process of data collection and evaluation, the monitoring of recovery can be implemented for various purposes. It may aid to prevent negative outcomes of training or competition, such as underrecovery, overtraining, or injuries. Further, it aims at establishing routines and strategies necessary to guarantee athletes' readiness for performance by restoring their depleted resources...
March 15, 2018: International Journal of Sports Physiology and Performance
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