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https://www.readbyqxmd.com/read/28814445/meeting-report-on-experimental-approaches-to-evolution-and-ecology-using-yeast-and-other-model-systems
#1
Daniel Jarosz, Aimée M Dudley
The fourth EMBO-sponsored conference on Experimental Approaches to Evolution and Ecology Using Yeast and Other Model Systems (https://www.embl.de/training/events/2016/EAE16-01/), was held at the EMBL in Heidelberg, Germany, October 19-23, 2016. The conference was organized by Judith Berman (Tel Aviv University), Maitreya Dunham (University of Washington), Jun-Yi Leu (Academia Sinica), and Lars Steinmetz (EMBL Heidelberg and Stanford University). The meeting attracted ~120 researchers from 28 countries and covered a wide range of topics in the fields of genetics, evolutionary biology, and ecology with a unifying focus on yeast as a model system...
August 16, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28671640/chrysin-attenuates-vcam-1-expression-and-monocyte-adhesion-in-lipopolysaccharide-stimulated-brain-endothelial-cells-by-preventing-nf-%C3%AE%C2%BAb-signaling
#2
Bo Kyung Lee, Won Jae Lee, Yi-Sook Jung
Adhesion of leukocytes to endothelial cells plays an important role in neuroinflammation. Therefore, suppression of the expression of adhesion molecules in brain endothelial cells may inhibit neuroinflammation. Chrysin (5,7-dihydroxyflavone) is a flavonoid component of propolis, blue passion flowers, and fruits. In the present study, we examined the effects of chrysin on lipopolysaccharide (LPS)-induced expression of vascular cell adhesion molecule-1 (VCAM-1) in mouse cerebral vascular endothelial (bEnd.3) cells...
July 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28476759/hla-a-24-02-as-a-common-risk-factor-for-antiepileptic-drug-induced-cutaneous-adverse-reactions
#3
MULTICENTER STUDY
Yi-Wu Shi, Fu-Li Min, Dong Zhou, Bin Qin, Juan Wang, Fa-Yun Hu, Ying-Kit Cheung, Jin-Hua Zhou, Xiang-Shu Hu, Jue-Qian Zhou, Lie-Min Zhou, Zhong-Zheng Zheng, Jie Pan, Na He, Zhi-Sheng Liu, Yun-Qi Hou, Kheng-Seang Lim, Yang-Mei Ou, Amy Hui-Ping Khor, Ching-Ching Ng, Bi-Jun Mao, Xiao-Rong Liu, Bing-Mei Li, Yao-Yun Kuan, Yong-Hong Yi, Xue-Lian He, Xiao-Yan Deng, Tao Su, Patrick Kwan, Wei-Ping Liao
OBJECTIVE: To investigate the involvement of human leukocyte antigen (HLA) loci in aromatic antiepileptic drug-induced cutaneous adverse reactions. METHODS: A case-control study was performed to detect HLA loci involved in aromatic antiepileptic drug-induced Stevens-Johnson syndrome in a southern Han Chinese population. Between January 1, 2006, and December 31, 2015, 91 cases of Stevens-Johnson syndrome induced by aromatic antiepileptic drugs and 322 matched drug-tolerant controls were enrolled from 8 centers...
June 6, 2017: Neurology
https://www.readbyqxmd.com/read/28348007/genome-wide-analysis-of-dna-methylation-and-acute-coronary-syndrome
#4
Jun Li, Xiaoyan Zhu, Kuai Yu, Haijing Jiang, Yizhi Zhang, Siyun Deng, Longxian Cheng, Xuezhen Liu, Jia Zhong, Xiaomin Zhang, Meian He, Weihong Chen, Jing Yuan, Ming Gao, Yansen Bai, Xu Han, Bing Liu, Xiaoting Luo, Wenhua Mei, Xiaosheng He, Shunchang Sun, Liyun Zhang, Hesong Zeng, Huizhen Sun, Chuanyao Liu, Yanjun Guo, Bing Zhang, Zhihong Zhang, Jinyan Huang, An Pan, Yu Yuan, Francesca Angileri, Bingxia Ming, Fang Zheng, Qiutang Zeng, Xiaobo Mao, Yudong Peng, Yi Mao, Ping He, Qing K Wang, Lu Qi, Frank B Hu, Liming Liang, Tangchun Wu
RATIONALE: Acute coronary syndrome (ACS) is a leading cause of death worldwide. Immune functions play a vital role in ACS development; however, whether epigenetic modulation contributes to the regulation of blood immune cells in this disease has not been investigated. OBJECTIVE: We conducted an epigenome-wide analysis with circulating immune cells to identify differentially methylated genes in ACS. METHODS AND RESULTS: We examined genome-wide methylation of whole blood in 102 ACS patients and 101 controls using HumanMethylation450 array, and externally replicated significant discoveries in 100 patients and 102 controls...
May 26, 2017: Circulation Research
https://www.readbyqxmd.com/read/28340427/identification-and-characterization-of-a-%C3%AE-defensin-gene-involved-in-the-immune-defense-response-of-channel-catfish-ictalurus-punctatus
#5
Jieyao Zhu, Hong Wang, Jun Wang, Xingli Wang, Shuang Peng, Yi Geng, Kaiyu Wang, Pin Ouyang, Zhiqiong Li, Xiaoli Huang, Defang Chen
Antimicrobial peptides are small peptides that play important roles in a host's innate immune response. As an important antimicrobial peptide, β-defensin widely distribute in mammals, insects and plants with broad-spectrum antimicrobial activity. In this study, the β-defensin gene of the channel catfish, Ictalurus punctatus, was cloned, sequenced, and subjected to a bioinformatic analysis. The β-defensin gene of the channel catfish contains three exons and two introns, and encodes a precursor peptide consisting of two domains: a signal peptide of 24 amino acid residues and a mature peptide of 43 amino acid residues...
May 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28333931/differential-gene-expression-in-patients-with-subsyndromal-symptomatic-depression-and-major-depressive-disorder
#6
Chengqing Yang, Guoqin Hu, Zezhi Li, Qingzhong Wang, Xuemei Wang, Chengmei Yuan, Zuowei Wang, Wu Hong, Weihong Lu, Lan Cao, Jun Chen, Yong Wang, Shunying Yu, Yimin Zhou, Zhenghui Yi, Yiru Fang
BACKGROUND: Subsyndromal symptomatic depression (SSD) is a subtype of subthreshold depressive and can lead to significant psychosocial functional impairment. Although the pathogenesis of major depressive disorder (MDD) and SSD still remains poorly understood, a set of studies have found that many same genetic factors play important roles in the etiology of these two disorders. Nowadays, the differential gene expression between MDD and SSD is still unknown. In our previous study, we compared the expression profile and made the classification with the leukocytes by using whole-genome cRNA microarrays among drug-free first-episode subjects with SSD, MDD and matched healthy controls (8 subjects in each group), and finally determined 48 gene expression signatures...
2017: PloS One
https://www.readbyqxmd.com/read/28282411/coevolution-with-bacteria-drives-the-evolution-of-aerobic-fermentation-in-lachancea-kluyveri
#7
Nerve Zhou, Krishna B S Swamy, Jun-Yi Leu, Michael J McDonald, Silvia Galafassi, Concetta Compagno, Jure Piškur
The Crabtree positive yeasts, such as Saccharomyces cerevisiae, prefer fermentation to respiration, even under fully aerobic conditions. The selective pressures that drove the evolution of this trait remain controversial because of the low ATP yield of fermentation compared to respiration. Here we propagate experimental populations of the weak-Crabtree yeast Lachancea kluyveri, in competitive co-culture with bacteria. We find that L. kluyveri adapts by producing quantities of ethanol lethal to bacteria and evolves several of the defining characteristics of Crabtree positive yeasts...
2017: PloS One
https://www.readbyqxmd.com/read/28266220/metabolic-mechanism-for-l-leucine-induced-metabolome-to-eliminate-streptococcus-iniae
#8
Chao-Chao Du, Man-Jun Yang, Min-Yi Li, Jun Yang, Bo Peng, Hui Li, Xuan-Xian Peng
Crucial metabolites that modulate hosts' metabolome to eliminate bacterial pathogens have been documented, but the metabolic mechanisms are largely unknown. The present study explores the metabolic mechanism for l-leucine-induced metabolome to eliminate Streptococcus iniae in tilapia. GC-MS-based metabolomics was used to investigate the tilapia liver metabolic profile in the presence of exogenous l-leucine. Thirty-seven metabolites of differential abundance were determined, and 11 metabolic pathways were enriched...
May 5, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28245931/disruption-of-thyroid-hormone-th-levels-and-th-regulated-gene-expression-by-polybrominated-diphenyl-ethers-pbdes-polychlorinated-biphenyls-pcbs-and-hydroxylated-pcbs-in-e-waste-recycling-workers
#9
Jing Zheng, Chun-Tao He, She-Jun Chen, Xiao Yan, Mi-Na Guo, Mei-Huan Wang, Yun-Jiang Yu, Zhong-Yi Yang, Bi-Xian Mai
Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) are the primary toxicants released by electronic waste (e-waste) recycling, but their adverse effects on people working in e-waste recycling or living near e-waste sites have not been studied well. In the present study, the serum concentrations of PBDEs, PCBs, and hydroxylated PCBs, the circulating levels of thyroid hormones (THs), and the mRNA levels of seven TH-regulated genes in peripheral blood leukocytes of e-waste recycling workers were analyzed...
February 25, 2017: Environment International
https://www.readbyqxmd.com/read/28131193/the-heterozygous-r1441c-mutation-of-leucine-rich-repeat-kinase-2-gene-in-a-chinese-patient-with-parkinson-disease-a-five-year-follow-up-and-literatures-review
#10
REVIEW
Fang Peng, Yi-Min Sun, Chen Chen, Su-Shan Luo, Da-Ke Li, Yi-Xuan Wang, Ke Yang, Feng-Tao Liu, Chuan-Tao Zuo, Zheng-Tong Ding, Yu An, Jian-Jun Wu, Jian Wang
BACKGROUND: Leucine-rich repeat kinase 2 gene (LRRK2) was recognized associated with both familial and sporadic Parkinson Disease (PD). Seven missense mutations (G2019S, R1441C, R1441G, R1441H, Y1699C, I2020T, N1437H) of it have been confirmed disease- causing. They were common among Caucasian PD patients, but rarely reported in Asian, especially in Chinese Han population. OBJECTIVES: We aimed to identify the frequencies of these seven mutations of LRRK2 in Chinese early-onset PD (EOPD) patients and analyze the phenotypes...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28105204/combining-fisetin-and-ionizing-radiation-suppresses-the-growth-of-mammalian-colorectal-cancers-in-xenograft-tumor-models
#11
Jyh-Der Leu, Bo-Shen Wang, Shu-Jun Chiu, Chun-Yuan Chang, Chien-Chih Chen, Fu-Du Chen, Shiirevnyamba Avirmed, Yi-Jang Lee
Fisetin (3,7,3',4'-tetrahydroxyflavone), which belongs to the flavonoid group of polyphenols and is found in a wide range of plants, has been reported to exhibit a number of biological activities in human cancer cells, including antioxidant, anti-inflammatory, antiangiogenic, anti-invasive and antiproliferative effects. Although previous in vitro studies have shown that fisetin treatment increases the apoptotic rate and enhances the radiosensitivity of human colorectal cancer cells, the in vivo effects of fisetin on tumor growth remain unclear...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/27920033/mitochondrial-nuclear-co-evolution-leads-to-hybrid-incompatibility-through-pentatricopeptide-repeat-proteins
#12
Han-Ying Jhuang, Hsin-Yi Lee, Jun-Yi Leu
Mitochondrial-nuclear incompatibility has a major role in reproductive isolation between species. However, the underlying mechanism and driving force of mitochondrial-nuclear incompatibility remain elusive. Here, we report a pentatricopeptide repeat-containing (PPR) protein, Ccm1, and its interacting partner, 15S rRNA, to be involved in hybrid incompatibility between two yeast species, Saccharomyces cerevisiae and Saccharomyces bayanus S. bayanus-Ccm1 has reduced binding affinity for S. cerevisiae-15S rRNA, leading to respiratory defects in hybrid cells...
January 2017: EMBO Reports
https://www.readbyqxmd.com/read/27896406/evaluation-of-rex-shunt-on-cavernous-transformation-of-the-portal-vein-in-children
#13
Ruo-Yi Wang, Jun-Feng Wang, Xiao-Gang Sun, Qian Liu, Jia-Long Xu, Qi-Gang Lv, Wei-Xiu Chen, Jin-Liang Li
BACKGROUND: Children with cavernous transformation of the portal vein (CTPV) develop severe complications from prehepatic portal hypertension, such as recurrent variceal bleeding and thrombocytopenia. In this study, we reported the results of 30 children with symptomatic CTPV that were treated by a Rex shunt. The effectiveness of this surgical approach was evaluated. METHODS: A retrospective review was performed of 30 children aged between 3 and 18 years with CTPV, who underwent a Rex shunt between 2008 and 2015...
April 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/27812096/experimental-evolution-reveals-interplay-between-sch9-and-polyploid-stability-in-yeast
#14
Yi-Jin Lu, Krishna B S Swamy, Jun-Yi Leu
Polyploidization has crucial impacts on the evolution of different eukaryotic lineages including fungi, plants and animals. Recent genome data suggest that, for many polyploidization events, all duplicated chromosomes are maintained and genome reorganizations occur much later during evolution. However, newly-formed polyploid genomes are intrinsically unstable and often quickly degenerate into aneuploidy or diploidy. The transition between these two states remains enigmatic. In this study, laboratory evolution experiments were conducted to investigate this phenomenon...
November 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27794459/plant-polysaccharides-used-as-immunostimulants-enhance-innate-immune-response-and-disease-resistance-against-aeromonas-hydrophila-infection-in-fish
#15
Erlong Wang, Xia Chen, Kaiyu Wang, Jun Wang, Defang Chen, Yi Geng, Weimin Lai, Xianchao Wei
Plant polysaccharides (PPS) are an important medicinal plant product, and play a major role in preventing and controlling infectious microbes in aquaculture. The present study investigated the effect of three PPS; Ficus carica polysaccharides (FCPS), Radix isatidis polysaccharides (RIPS), and Schisandra chinensis polysaccharides (SCPS), used as feed additives, on innate immune responses and disease resistance against Aeromonas hydrophila in crucian carp. Results show that crucian carp fed with these PPS showed significant (p < 0...
December 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27760141/correlation-between-hla-a-b-and-drb1-alleles-and-severe-fever-with-thrombocytopenia-syndrome
#16
Shu-Jun Ding, Yi Zhang, Xiao-Mei Zhang, Xiao-Lin Jiang, Bo Pang, Yong-Hong Song, Jian-Xing Wang, Yao-Wen Pei, Chuan-Fu Zhu, Xian-Jun Wang, Xue-Jie Yu
OBJECTIVE: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever caused by a tick-borne bunyavirus (SFTSV) in East Asian countries. The role of human leukocyte antigen (HLA) in resistance and susceptibility to SFTSV is not known. We investigated the correlation of HLA locus A, B and DRB1 alleles with the occurrence of SFTS. METHODS: A total of 84 confirmed SFTS patients (patient group) and 501 unrelated non-SFTS patients (healthy individuals as control group) from Shandong Province were genotyped by PCR-sequence specific oligonucleotide probe (PCR-SSOP) for HLA-A, B and DRB1 loci...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27596364/lect2-drives-haematopoietic-stem-cell-expansion-and-mobilization-via-regulating-the-macrophages-and-osteolineage-cells
#17
Xin-Jiang Lu, Qiang Chen, Ye-Jing Rong, Guan-Jun Yang, Chang-Hong Li, Ning-Yi Xu, Chao-Hui Yu, Hui-Ying Wang, Shun Zhang, Yu-Hong Shi, Jiong Chen
Haematopoietic stem cells (HSCs) can differentiate into cells of all lineages in the blood. However, the mechanisms by which cytokines in the blood affect HSC homeostasis remain largely unknown. Here we show that leukocyte cell-derived chemotaxin 2 (LECT2), a multifunctional cytokine, induces HSC expansion and mobilization. Recombinant LECT2 administration results in HSC expansion in the bone marrow and mobilization to the blood via CD209a. The effect of LECT2 on HSCs is reduced after specific depletion of macrophages or reduction of osteolineage cells...
2016: Nature Communications
https://www.readbyqxmd.com/read/27574827/the-outer-membrane-proteins-of-stenotrophomonas-maltophilia-are-potential-vaccine-candidates-for-channel-catfish-ictalurus-punctatus
#18
Xingli Wang, Lang Peng, Kaiyu Wang, Jun Wang, Yang He, Erlong Wang, Defang Chen, Ping Ouyang, Yi Geng, Xiaoli Huang
Channel catfish (Ictalurus punctatus) is an important agricultural fish that has been plagued by Stenotrophomonas maltophilia (S. maltophilia) infections in recent years, some of them severe. The outer membrane proteins (OMPs) of S. maltophilia are one of the most immunogenic and highly conserved candidates for vaccine development in aquaculture. The present study investigated OMPs of S. maltophilia as vaccine on immune response and disease resistance against S. maltophilia of channel catfish and investigated the enhancement effect of natural adjuvants Propolis (Pro), FIG polysaccharide (Fcps), Glycyrrhizine (Gly) to OMPs of S...
October 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27514781/identification-and-characterization-of-a-novel-toll-like-receptor-4-homologue-in-blunt-snout-bream-megalobrama-amblycephala
#19
Leilei Tang, Xinying Xiang, Yuhong Jiang, Yina Lv, Yi Zhou, Huan Zhong, Jun Xiao, Fuyun Zhang, Hongyang Jiang, Jinpeng Yan
Toll-like receptors (TLRs) are central players in the innate immune system in response to a wide range of pathogen infection. Among various TLRs, TLR4 plays a key role in recognition of bacterial lipopolysaccharides (LPS). In the present study, we identified and characterized a novel TLR4 homologue (maTLR4b) in blunt snout bream (Megalobrama amblycephala) which was significantly distinct from previously reported M. amblycephala TLR4 (tentatively named maTLR4a). The results showed that the complete cDNA sequence of maTLR4b was 3261 bp with an open reading frame encoding a polypeptide of 820 amino acids, and that its genomic sequence was 3793 bp, which had 3 exons...
October 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27386516/mutation-at-a-distance-caused-by-homopolymeric-guanine-repeats-in-saccharomyces-cerevisiae
#20
Michael J McDonald, Yen-Hsin Yu, Jheng-Fen Guo, Shin Yen Chong, Cheng-Fu Kao, Jun-Yi Leu
Mutation provides the raw material from which natural selection shapes adaptations. The rate at which new mutations arise is therefore a key factor that determines the tempo and mode of evolution. However, an accurate assessment of the mutation rate of a given organism is difficult because mutation rate varies on a fine scale within a genome. A central challenge of evolutionary genetics is to determine the underlying causes of this variation. In earlier work, we had shown that repeat sequences not only are prone to a high rate of expansion and contraction but also can cause an increase in mutation rate (on the order of kilobases) of the sequence surrounding the repeat...
May 2016: Science Advances
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