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Hwei-jan hsu

Yueh Cho, Chun-Ming Lai, Kun-Yang Lin, Hwei-Jan Hsu
Adult stem cells maintain tissue homeostasis. This unique capability largely depends on the stem cell niche, a specialized microenvironment, which preserves stem cell identity through physical contacts and secreted factors. In many cancers, latent tumor cell niches are thought to house stem cells and aid tumor initiation. However, in developing tissue and cancer it is unclear how the niche is established. The well-characterized germline stem cells (GSCs) and niches in the Drosophila melanogaster ovary provide an excellent model to address this fundamental issue...
May 15, 2018: G3: Genes—Genomes—Genetics
Yu-Han Su, Elham Rastegri, Shih-Han Kao, Chun-Min Lai, Kun-Yang Lin, Hung-Yu Liao, Mu-Hsiang Wang, Hwei-Jan Hsu
Diet is an important regulator of stem cell homeostasis; however, the underlying mechanisms of this regulation are not fully known. Here, we report that insulin signaling mediates dietary maintenance of Drosophila ovarian germline stem cells (GSCs) by promoting the extension of niche escort cell (EC) membranes to wrap around GSCs. This wrapping may facilitate the delivery of bone morphogenetic protein stemness factors from ECs in the niche to GSCs. In addition to the effects on GSCs, insulin signaling-mediated regulation of EC number and protrusions controls the division and growth of GSC progeny...
April 5, 2018: Development
Chen-Yuan Tseng, Hwei-Jan Hsu
Snail, a zinc-finger transcription factor, controls the process of epithelial-mesenchymal transition, and ectopic expression of this protein may produce cells with stem cell properties. Because the effect of Snail expression in ovarian epithelial cells remains unclear, we generated Drosophila ovarian follicle stem cells (FSCs) with homozygous Scutoid (Sco) mutation. The Sco mutation is a reciprocal transposition that is known to induce ectopic Snail activity. We found that Sco mutant FSCs showed excess proliferation and high competitiveness for niche occupancy, and the descendants of this lineage formed outgrowths that failed to enter the endocycle...
2017: PloS One
Hsin-Hsien Li, Hsao-Hsun Hsu, Gwo-Jyh Chang, I-Chen Chen, Wan-Jing Ho, Pei-Chen Hsu, Wei-Jan Chen, Jong-Hwei S Pang, Chung-Chi Huang, Ying-Ju Lai
Prostacyclin agonists that bind the prostacyclin receptor (IP) to stimulate cAMP synthesis are effective vasodilators for the treatment of idiopathic pulmonary arterial hypertension (IPAH), but this signaling may occur through nuclear peroxisome proliferator-activated receptor-γ (PPARγ). There is evidence of scant IP and PPARγ expression but stable prostanoid EP4 receptor (EP4 ) expression in IPAH patients. Both IP and EP4 functionally couple with stimulatory G protein (Gs ), which activates signal transduction...
March 1, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
Ying-Ju Lai, Hsao-Hsun Hsu, Gwo-Jyh Chang, Shu-Hui Lin, Wei-Jan Chen, Chung-Chi Huang, Jong-Hwei S Pang
The depletion of cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) and phosphatase and tensin homolog (PTEN) is the critical mediator of pulmonary arterial hypertension (PAH). We hypothesized that the activation of phosphorylated CREB (pCREB) and PTEN could inhibit the AKT signaling pathway to attenuate pulmonary arterial remodeling in rats with monocrotaline-induced PAH. We observed decreased PTEN and pCREB in idiopathic PAH versus control tissue. We reduced PTEN using small interfering RNA in human control pulmonary arterial smooth muscle cells (PASMCs) and observed an increase in pAKT...
August 30, 2017: Scientific Reports
Chun-Ming Lai, Kun-Yang Lin, Shih-Han Kao, Yi-Ning Chen, Fu Huang, Hwei-Jan Hsu
Stem cells require different types of supporting cells, or niches, to control stem cell maintenance and differentiation. However, little is known about how those niches are formed. We report that in the development of the Drosophila melanogaster ovary, the Hedgehog (Hh) gradient sets differential cell affinity for somatic gonadal precursors to specify stromal intermingled cells, which contributes to both germline stem cell maintenance and differentiation niches in the adult. We also report that Traffic Jam (an orthologue of a large Maf transcription factor in mammals) is a novel transcriptional target of Hh signaling to control cell-cell adhesion by negative regulation of E-cadherin expression...
May 1, 2017: Journal of Cell Biology
Hwei-Jan Hsu, Daniela Drummond-Barbosa
The effect of diet on reproduction is well documented in a large number of organisms; however, much remains to be learned about the molecular mechanisms underlying this connection. The Drosophila ovary has a well described, fast and largely reversible response to diet. Ovarian stem cells and their progeny proliferate and grow faster on a yeast-rich diet than on a yeast-free (poor) diet, and death of early germline cysts, degeneration of early vitellogenic follicles and partial block in ovulation further contribute to the ∼60-fold decrease in egg laying observed on a poor diet...
January 2017: Gene Expression Patterns: GEP
Yen-Hsuan Ni, Mei-Hwei Chang, Chyi-Feng Jan, Hong-Yuan Hsu, Huey-Ling Chen, Jia-Feng Wu, Ding-Shinn Chen
BACKGROUND & AIMS: Taiwan began a universal hepatitis B virus (HBV) vaccination program for infants in July 1984. The seroprevalence of hepatitis B surface antigen (HBsAg) decreased from 9.8% before the vaccination program to less than 1% by 25 years afterward. We continued to monitor HBV infections in this population. METHODS: We conducted a series of serologic and epidemiologic surveys in the Taipei metropolitan area every 5 years from 1984 through 2014. From January 1 through December 31 of 2014, we collected serum samples from 4605 apparently healthy individuals (ages: 287 were <3 y, 405 were 3-6 y, 675 were 7-12 y, 686 were 13-18 y, 468 were 18-22 y, and 2084 were 22-50 y)...
September 2016: Clinical Gastroenterology and Hepatology
Chen-Yuan Tseng, Shih-Han Kao, Hwei-Jan Hsu
Epithelial stem cells undergo constant self-renewal and differentiation to maintain the homeostasis of epithelial tissues that undergo rapid turnover. Recent studies have shown that the epithelial-mesenchymal transition (EMT), which is primarily mediated by Snail via the suppression of E-cadherin, is able to generate cells with stem cell properties. However, the role of Snail in epithelial stem cells remains unclear. Here, we report that Snail directly controls proliferation of follicle stem cells (FSCs) in Drosophila females...
June 15, 2016: Developmental Biology
Chen-Yuan Tseng, Shih-Han Kao, Chih-Ling Wan, Yueh Cho, Shu-Yun Tung, Hwei-Jan Hsu
No abstract text is available yet for this article.
December 2015: PLoS Genetics
Kun-Yang Lin, Shih-Han Kao, Chun-Ming Lai, Ciao-Ting Chen, Chang-Yi Wu, Hwei-Jan Hsu, Wen-Der Wang
Wnt/β-catenin signaling controls various cell fates in metazoan development, and its dysregulation is often associated with cancer formation. However, regulations of this signaling pathway are not completely understood. Here, we report that Lzap, a tumor suppressor, controls nuclear translocation of β-catenin. In zebrafish embryos disruption of lzap increases the expression of chordin (chd), which encodes a bone morphogenetic protein (BMP) antagonist that is localized in prospective dorsal cells and promotes dorsal fates...
December 11, 2015: Journal of Biological Chemistry
Jih-Luh Tang, Hsiang-Chi Kung, Weng-Chi Lei, Ming Yao, Un-In Wu, Szu-Chun Hsu, Chien-Ting Lin, Chi-Cheng Li, Shang-Ju Wu, Hsin-An Hou, Wen-Chien Chou, Shang-Yi Huang, Woei Tsay, Yao-Chang Chen, Yee-Chun Chen, Shan-Chwen Chang, Bor-Sheng Ko, Hwei-Fang Tien
Invasive fungal infections (IFIs) is an important complication for acute myeloid leukemia (AML) patients receiving induction chemotherapy. However, the epidemiological information is not clear in Southeastern Asia, an area of potential high incidences of IFIs. To clarify it, we enrolled 298 non-M3 adult AML patients receiving induction chemotherapy without systemic anti-fungal prophylaxis from Jan 2004 to Dec 2009, when we applied a prospective diagnostic and treatment algorithm for IFIs. Their demographic parameters, IFI characters, and treatment outcome were collected for analysis...
2015: PloS One
Jen-Chieh Lin, Shing Hu, Pei-Hung Ho, Hwei-Jan Hsu, John H Postlethwait, Bon-chu Chung
HSD3B catalyzes the synthesis of δ4 steroids such as progesterone in the adrenals and gonads. Individuals lacking HSD3B2 activity experience congenital adrenal hyperplasia with imbalanced steroid synthesis. To develop a zebrafish model of HSD3B deficiency, we characterized 2 zebrafish hsd3b genes. Our phylogenetic and conserved synteny analyses showed that the tandemly duplicated human HSD3B1 and HSD3B2 genes are coorthologs of zebrafish hsd3b1 on chromosome 9 (Dre9), whereas the gene called hsd3b2 resides on Dre20 in an ancestral chromosome segment, from which its ortholog was lost in the tetrapod lineage...
August 2015: Endocrinology
Huey-Ling Chen, Chien-Nan Lee, Chin-Hao Chang, Yen-Hsuan Ni, Ming-Kwang Shyu, Shih-Ming Chen, Jen-Jan Hu, Hans Hsienhong Lin, Lu-Lu Zhao, Shu-Chi Mu, Ming-Wei Lai, Chyi-Long Lee, Hsien-Ming Lin, Ming-Song Tsai, Jenn-Jeih Hsu, Ding-Shinn Chen, K Arnold Chan, Mei-Hwei Chang
UNLABELLED: The efficacy and safety of maternal tenofovir disoproxil fumarate (TDF) in reducing mother-to-infant hepatitis B virus (HBV) transmissions is not clearly understood. We conducted a prospective, multicenter trial and enrolled 118 hepatitis B surface antigen (HBsAg)- and hepatitis B e antigen-positive pregnant women with HBV DNA ≥7.5 log10 IU/mL. The mothers received no medication (control group, n = 56, HBV DNA 8.22 ± 0.39 log10 IU/mL) or TDF 300 mg daily (TDF group, n = 62, HBV DNA 8...
August 2015: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Chen-Yuan Tseng, Shih-Han Kao, Chih-Ling Wan, Yueh Cho, Shu-Yun Tung, Hwei-Jan Hsu
Stem cells have an innate ability to occupy their stem cell niche, which in turn, is optimized to house stem cells. Organ aging is associated with reduced stem cell occupancy in the niche, but the mechanisms involved are poorly understood. Here, we report that Notch signaling is increased with age in Drosophila female germline stem cells (GSCs), and this results in their removal from the niche. Clonal analysis revealed that GSCs with low levels of Notch signaling exhibit increased adhesiveness to the niche, thereby out-competing their neighbors with higher levels of Notch; adhesiveness is altered through regulation of E-cadherin expression...
December 2014: PLoS Genetics
Wen-Der Wang, Guan-Ting Chen, Hwei-Jan Hsu, Chang-Yi Wu
Paclobutrazol (PBZ), a trazole-containing fungicide and plant growth retardant, has been widely used for over 30 years to regulate plant growth and promote early fruit setting. Long-term usage of PBZ in agriculture and natural environments has resulted in residual PBZ in the soil and water. Chronic exposure to waterborne PBZ can cause various physiological effects in fish, including hepatic steatosis, antioxidant activity, and disruption of spermatogenesis. We have previously shown that PBZ also affects the rates of zebrafish embryonic survival and hatching, and causes developmental failure of the head skeleton and eyes; here, we further show that PBZ has embryonic toxic effects on digestive organs of zebrafish, and describe the underlying mechanisms...
February 2015: Aquatic Toxicology
Shih-Han Kao, Chen-Yuan Tseng, Chih-Ling Wan, Yu-Han Su, Chang-Che Hsieh, Haiwei Pi, Hwei-Jan Hsu
Aging influences stem cells, but the processes involved remain unclear. Insulin signaling, which controls cellular nutrient sensing and organismal aging, regulates the G2 phase of Drosophila female germ line stem cell (GSC) division cycle in response to diet; furthermore, this signaling pathway is attenuated with age. The role of insulin signaling in GSCs as organisms age, however, is also unclear. Here, we report that aging results in the accumulation of tumorous GSCs, accompanied by a decline in GSC number and proliferation rate...
February 2015: Aging Cell
Chih-Chieh Hsu, Chiao-En Wu, Jen-Shi Chen, Jeng-Hwei Tseng, Kun-Chun Chiang, Yu-Yin Liu, Chun-Yi Tsai, Chi-Tung Cheng, Tsung-Wen Chen, Yi-Yin Jan, Ta-Sen Yeh, Yen-Yang Chen, Chun-Nan Yeh
AIM: Imatinib mesylate (IM) is effective in metastatic gastrointestinal stromal tumor (GIST) patients; however, disease progression eventually occurs due to IM resistance or intolerance. Treatment options include IM escalation or a direct shift to sunitinib, but comparison of these strategies is required. PATIENTS AND METHODS: This study included 91 out of 214 metastatic GIST patients treated with IM, who experienced progression or intolerance between August 2001 and December 2012 at the Chang Gung Memorial Hospital...
September 2014: Anticancer Research
Kun-Chun Chiang, Chun-Nan Yeh, Jun-Te Hsu, Yi-Yin Jan, Li-Wei Chen, Sheng-Fong Kuo, Masashi Takano, Atsushi Kittaka, Tai C Chen, Wen-Tsung Chen, Jong-Hwei S Pang, Ta-Sen Yeh, Horng-Heng Juang
Pancreatic cancer (PDA) is a devastating disease and there is no effective treatment available at present. To develop new regiments against PDA is urgently needed. Previously we have shown that vitamin D analog, MART-10 (19-nor-2α-(3-hydroxypropyl)-1α,25(OH)2D3), exerted potent antiproliferative effect on PDA in vitro and in vivo without causing hypercalcemia. Since metastasis is the major cause of PDA-related death, we therefore investigate the anti-metastasis effect of MART-10 on PDA. Our results showed that both 1α,25(OH)2D3 and MART-10 repressed migration and invasion of BxPC-3 and PANC cells with MART-10 much more potent than 1α,25(OH)2D3...
November 28, 2014: Cancer Letters
Aulia Puspita Anugra Yekti, Hwei-Jan Hsu, Wen-Der Wang
Paclobutrazol (PBZ), a trazole-containing fungicide, is widely used on food crops. Frequent usage of PBZ may contaminate water, but its toxicity to aquatic organisms is understudied. Although the chronic effects of PBZ exposure on reproductive, antioxidant defense, and liver metabolism systems in rockfish have been reported, the toxic effects of PBZ on aquatic embryos are unknown. Here, we report that PBZ disrupts the development of heart and craniofacial cartilage in zebrafish embryos, and decreases their survival and hatching rates...
February 2014: Zebrafish
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