keyword
MENU ▼
Read by QxMD icon Read
search

Diabetic wound

keyword
https://www.readbyqxmd.com/read/28448268/the-effect-of-pycnogenol-on-wound-healing-in-diabetic-rats
#1
Elif Dogan, Latif Yanmaz, Semin Gedikli, Ugur Ersoz, Zafer Okumus
Pycnogenol (PYC), an extract of pine bark, is known to have photoprotective, antimicrobial, antioxidant, and anti-inflammatory properties. An in vivo study was conducted to evaluate the effects of PYC treatment on wound healing in 48 adult male Sprague-Dawley rats, of which 24 were injected with a single dose of alloxan to induce diabetes. Three (3) excisional skin wounds (1.3 cm x 1.3 cm x 2 mm) were created in each healthy and diabetic animal. One (1) wound in each animal was left untreated, 1 was treated daily with a cleanser (ethacridine lactate) and covered with silver sulfadiazine (SSD), and 1 was treated with PYC powder (30 mg)...
April 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28448266/a-prospective-randomized-blinded-controlled-trial-comparing-transdermal-continuous-oxygen-delivery-to-moist-wound-therapy-for-the-treatment-of-diabetic-foot-ulcers
#2
Vickie R Driver, Alexander Reyzelman, Jill Kawalec, Michael French
Worldwide, diabetic foot ulcers (DFUs) continue to exact a major burden on patients and health care providers. Although hyperbaric oxygen therapy is well-known as an adjunct option, less is known about the efficacy of transdermal continuous oxygen therapy (TCOT). A prospective, randomized, blinded, multicenter, parallel study was conducted from October 2009 to November 2012 to evaluate healing time and the proportion of DFUs healed after 12 weeks of moist wound therapy (MWT) with or without TCOT. Study participants (persons with type 1 or type 2 diabetes and a nonhealing [>1-month but <1-year duration], 1 cm² to 10 cm² in area, infection-free DFU) were randomized to TCOT or a sham device (control) in addition to receiving MWT...
April 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28448264/use-of-ovine-based-collagen-extracellular-matrix-and-gentian-violet-methylene-blue-antibacterial-foam-dressings-to-help-improve-clinical-outcomes-in-lower-extremity-wounds-a-retrospective-cohort-study
#3
Eric L Lullove
Dressings that provide broad spectrum metalloprotease reduction along with inherent aspects of an extracellular matrix may contribute to improved wound healing outcomes and shorter treatment times. OBJECTIVE: The author performed a retrospective case series analysis to determine the clinical outcomes of regular debridement with the use of ovine-based collagen extracellular matrix dressings and gentian violet/methylene blue polyurethane antibacterial foam dressings in treating 53 patients with 53 chronic lower extremity wounds (diabetic foot ulcers [DFUs], venous leg ulcers, and heel pressure ulcers)...
April 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28448262/an-unusually-large-carbuncle-of-the-temporofacial-region-demonstrating-remarkable-post-debridement-wound-healing-process-a-case-report
#4
Humaid Ahmad, Sheeraz Shakoor Siddiqui
Skin carbuncles are debilitating skin infections commonly seen in elderly patients with diabetes. These infections develop when a cluster of adjacent furuncles coalesce to form one inflammatory mass. While they commonly occur on the nape of the neck and back, rarer sites involving the face and head have been noted. Management of these rare sites is urgent because of the potential intracranial complications and the surgical outcome is often unsatisfactory due to associated facial scarring. Intraoral drainage is advocated to avoid this; however, when the carbuncle involves a larger area, debridement from the exterior is necessary...
April 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28447876/intrinsic-mesenchymal-stem-cell-dysfunction-in-diabetes-mellitus-implications-for-autologous-cell-therapy
#5
Mari van de Vyver
Mesenchymal stem cells derived from bone marrow (BM-MSCs) have multi-functional properties that have made them a promising therapeutic agent for many regenerative, anti-inflammatory, and auto-immune applications. Under chronic pathological conditions, however, BM-MSCs can become functionally compromised due to long term exposure to changes in the systemic and localized stem cell niche micro-environments. In addition to the fact that functionally compromised BM-MSCs may be therapeutically ineffective, the impairment of BM-MSCs is potentially a contributing factor to disease progression and the development of co-morbidities...
April 27, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28447455/efficiency-and-safety-of-%C3%AE-cd-d3-7-as-an-sirna-carrier-for-decreasing-mmp-9-expression-and-improving-wound-healing-in-diabetic-rats
#6
Na Li, Hengcong Luo, Meng Ren, Li-Ming Zhang, Wei Wang, Cheng Lin Pan, Liqun Yang, Guojuan Lao, Junjie Deng, Kaijin Mai, Kan Sun, Chuan Yang, Li Yan
Over-expression of MMP-9 is critical for diabetic chronic wounds involved in the refractory wound healing process. We aimed to develop a strategy through RNAi to decrease MMP-9 expression and improving diabetic wound healing. We had explored β-CD-(D3)7 as a gene carrier to take siRNA effectively interfere with MMP-9 expression. It has been proved that β-CD-(D3)7 could be used as an effective siRNA delivery system. In this study we want to know exactly about the efficiency and safety of β-CD-(D3)7/MMP-9 siRNA for improving wound healing in diabetic rats...
April 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28445367/adipose-tissue-drives-response-to-ischemia-reperfusion-injury-in-a-murine-pressure-sore-model
#7
Madeleine J Gust, Seok Jong Hong, Robert C Fang, Steven T Lanier, Donald W Buck, Jennifer M Nuñez, Shengxian Jia, Eugene D Park, Robert D Galiano, Thomas A Mustoe
BACKGROUND: Ischemia-reperfusion injury contributes significantly to the pathogenesis of chronic wounds such as pressure sores and diabetic foot ulcers. The authors' laboratory has previously developed a cyclical murine ischemia-reperfusion injury model. The authors here use this model to determine factors underlying tissue response to ischemia-reperfusion injury. METHODS: C57BL/6 mice were subjected to cycles of ischemia-reperfusion that varied in number (one to four cycles) and duration of ischemia (1 to 2 hours)...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28444845/preoperative-sepsis-is-an-independent-risk-factor-for-major-complications-after-lower-extremity-amputation-in-patients-with-diabetic-end-stage-renal-disease
#8
Young Hwan Park, Jong Hyub Song, Gi Won Choi, Hak Jun Kim
AIM: Patients with diabetic end-stage renal disease (ESRD) are at increased risk of lower extremity amputation (LEA) and postoperative complications compared to those without diabetic ESRD. This study sought to determine the factors that influence complications following LEA in patients with diabetic ESRD. METHODS: A total of 41 patients with diabetic ESRD (total of 46 amputations) who underwent LEA were enrolled in this study. The electronic medical records were retrospectively reviewed to identify the predictors of postoperative complications...
April 26, 2017: Nephrology
https://www.readbyqxmd.com/read/28440196/mir-126-as-a-therapeutic-agent-for-diabetes-mellitus
#9
Elham Pishavar, Javad Behravan
Diabetes mellitus (DM) is a metabolic disorder which is characterized by inappropriate hyperglycemia. It is becoming an epidemic disease in developing countries. Diabetic patients are frequently afflicted with a vascular dysfunction and wound healing defect. In spite of intense investigations, over the past 2-3 decades, optimal treatment options and related mechanisms are still unclear. MicroRNAs (miRNAs) are small noncoding RNAs considered as regulators of a vast number of biological processes including endothelial cell function controlling molecular signaling pathways in diabetic pathogenesis...
April 24, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28440050/enzymatic-debridement-with-collagenase-in-wounds-and-ulcers-a-systematic-review-and-meta-analysis
#10
Jérôme Patry, Virginie Blanchette
Enzymatic debridement with collagenase is a technique that is commonly used in clinical practice. This systematic review examines the effect of collagenase on all kinds of wounds, compared to an alternative therapy, on wound healing, wound bed characteristics, cost-effectiveness and the occurrence of adverse events. We conducted a systematic literature search on available literature in Cochrane databases, MEDLINE, EMBASE and CINAHL. Two investigators independently assessed the titles and abstracts of all randomised controlled trials obtained involving collagenase of all kinds of wounds based on inclusion criteria...
April 25, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28438078/ten-year-follow-up-of-a-case-of-necrotizing-fasciitis-successfully-treated-with-negative-pressure-wound-therapy-dermal-regeneration-template-application-and-split-thickness-skin-autograft
#11
Sagi Martinov, Soccoro Ortiz
INTRODUCTION: Necrotizing fasciitis is a rapidly progressive and often fatal infection of the fasciae and subcutaneous tissues. PATIENT AND METHODS: In this case report, we present the treatment of a 63-year-old patient suffering from diabetes mellitus, who was admitted to the emergency unit for severe right gluteal pain, which had begun 24 hours before admission. Cutaneous symptoms, oliguria, metabolic acidosis, acute renal failure, severe hypotension, and tachycardia occurred, and the patient was admitted to Intensive Care a few hours after initial admission...
April 25, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28436270/does-physiological-stress-slowdown-wound-healing-in-patients-with-diabetes
#12
Javad Razjouyan, Gurtej Singh Grewal, Talal K Talal, David G Armstrong, Joseph L Mills, Bijan Najafi
BACKGROUND: Poor healing is an important contributing factor to amputation among patients with diabetic foot ulcers (DFUs). Physiological stress may slow wound healing and increase susceptibility to infection. OBJECTIVES: The objective was to examine the association between heart rate variability (HRV) as an indicator of physiological stress response and healing speed (HealSpeed) among outpatients with active DFUs. DESIGN AND METHODS: Ambulatory patients with diabetes with DFUs (n = 25, age: 59...
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28435009/selective-small-molecule-inhibitors-as-chemical-tools-to-define-the-roles-of-matrix-metalloproteinases-in-disease
#13
REVIEW
Jayda E Meisel, Mayland Chang
The focus of this article is to highlight novel inhibitors and current examples where the use of selective small-molecule inhibitors has been critical in defining the roles of matrix metalloproteinases (MMPs) in disease. Selective small-molecule inhibitors are surgical chemical tools that can inhibit the targeted enzyme; they are the method of choice to ascertain the roles of MMPs and complement studies with knockout animals. This strategy can identify targets for therapeutic development as exemplified by the use of selective small-molecule MMP inhibitors in diabetic wound healing, spinal cord injury, stroke, traumatic brain injury, cancer metastasis, and viral infection...
April 20, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28430667/investigating-point-to-point-emissivity-variation-of-wounded-tissue
#14
Ellen Keenan, Georgina Gethin, Louisa Flynn, David Watterson, Gerard O'Connor
Infrared cameras are becoming increasingly popular in clinical applications as they allow fast, non-contact temperature measurements. As abnormal heat distribution can indicate illness, infrared cameras have been applied in the prediction, diagnosis and monitoring of conditions (Lahiri, Bagavathiappan, Jayakumar, & Philip, 2012). Current practices, however, often overlook the importance of emissivity when taking thermal measurements. The consensus is that human skin has an emissivity of 0.98 (Soerensen et al...
April 21, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28429928/a-dual-enzyme-hydrogen-peroxide-generation-machinery-in-hydrogels-supports-antimicrobial-wound-treatment
#15
Daniela Huber, Gregor Tegl, Anna Mensah, Bianca Beer, Martina Baumann, Nicole Borth, Christoph Sygmund, Roland Ludwig, Georg M Guebitz
The aging population and accompanying diseases like diabetes resulted in an increased occurrence of chronic wounds. Topical wound treatment with antimicrobial agents to inhibit bacterial invasion and promote wound healing is often associated with difficulties. Here, we investigated the potential of succinyl chitosan (SC)-carboxymethyl cellulose (CMC) hydrogels which constantly release clinically relevant levels of hydrogen peroxide (H2O2). CMC hydrogel matrix was in situ converted by limited hydrolysis by a cellulase into substrates accepted by cellobiose dehydrogenase (CDH) for continuous production of H2O2 (30 μM over 24 h)...
April 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28427246/nanotechnology-and-diabetic-wound-healing-a-review
#16
Dinesh Kumar Chellappan, Yap Yenese, Chew Chian Wei, Gaurav Gupta
The incidence of diabetes has been on the rise and the rate of rise since the turn of this century has been phenomenal. One of the various battling issues faced by diabetics all over the globe is the management of diabetic wounds. Currently there are several management strategies to deal with the treatment of diabetic wounds. The conventional methods have several limitations. One of the major limitations is the rate and progression of healing of a diabetic wound when adopting a conventional diabetic wound management therapy...
April 21, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28426572/nonhealing-ulcers-in-patients-with-tophaceous-gout-a-systematic-review
#17
Gretl Lam, Frank L Ross, Ernest S Chiu
GENERAL PURPOSE: To provide information from a review of the literature about chronic ulcers associated with tophaceous gout. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After participating in this educational activity, the participant should be better able to:1. Identify the pathophysiology of tophaceous gout, its presentation, phases, and common comorbidities...
May 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28425868/pomegranate-as-a-possible-treatment-in-reducing-risk-of-developing-wound-healing-obesity-neurodegenerative-disorders-and-diabetes-mellitus
#18
Manaf AlMatar, Md Rashedul Islam, Othman Albari, Işıl Var, Fatih Köksal
Four distinguished although overlying stages make up the methodical procedure of wound healing, which are hemostasis, inflammation, proliferation and remodelling. Multiple sclerosis (MS) comprises a persistent inflammatory infection of the central nervous system, and is related to demyelination, neurodegeneration, as well as susceptibility to oxidative pressure. Obesity signifies a swiftly developing danger to the wellbeing of populations in a rising number of nations. Usually called diabetes mellitus (DM) by medical practitioners, diabetes details a collection of metabolic diseases within which the individual has raised blood glucose, either due to an insufficiency of insulin generation, or the lack of suitable response by the body to insulin, or both...
April 19, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28425265/effects-of-ankaferd-bloodstopper-on-dermal-healing-in-diabetic-rats
#19
Sertaç Aktop, Burcu Çevreli, Deniz Genç, Emel Serdaroğlu Kaşikçi, Nil Çomunoğlu Üstündağ, Noushin Zibandeh, Elif Merve Özcan, Gökhan Göçmen, Mehmet Kamil Göker, İsmail Tayfun Uzbay, Tunç Akkoç
BACKGROUND/AIM: Diabetes mellitus inhibits wound-induced angiogenesis, impairs the wound healing process, and leads to the development of chronic wounds. Ankaferd BloodStopper (ABS) is a new and promising local haemostatic agent. Although the mechanism of ABS-mediated haemostasis is well established, little is known about the associated histological and biochemical tissue reactions. The aim of this study was to evaluate the effects of this new-generation local haemostatic agent on short-term soft-tissue healing in streptozotocin (STZ)-treated rats...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28424290/skin-derived-precursors-from-human-subjects-with-type-2-diabetes-yield-dysfunctional-vascular-smooth-muscle-cells
#20
Sarah Katherina Steinbach, Terrence M Yau, Maral Ouzounian, Husam Abdel-Qadir, Mark Chandy, Thomas Waddell, Mansoor Husain
Objective: Few methods enable molecular and cellular studies of vascular aging or type-2 diabetes (T2D). Here we report a new approach to studying human vascular smooth muscle cell (VSMC) pathophysiology by examining VSMCs differentiated from progenitors found in skin. Approach and Results: Skin-derived precursors (SKPs) were cultured from biopsies (N=164, ~1 cm(2)) taken from the edges of surgical incisions of older adults (N=158; males 72%; mean age 62.7±13 years) undergoing cardiothoracic surgery, and differentiated into VSMCs at high efficiency (>80% yield)...
April 19, 2017: Clinical Science (1979-)
keyword
keyword
21862
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"