keyword
https://read.qxmd.com/read/37407615/control-of-sustained-attention-and-impulsivity-by-g-q-protein-signalling-in-parvalbumin-interneurons-of-the-anterior-cingulate-cortex
#21
JOURNAL ARTICLE
Martin M Jendryka, Uwe Lewin, Bastiaan van der Veen, Sampath K T Kapanaiah, Vivien Prex, Daniel Strahnen, Thomas Akam, Birgit Liss, Anton Pekcec, Wiebke Nissen, Dennis Kätzel
The anterior cingulate cortex (ACC) has been implicated in attention deficit hyperactivity disorder (ADHD). More specifically, an appropriate balance of excitatory and inhibitory activity in the ACC may be critical for the control of impulsivity, hyperactivity, and sustained attention which are centrally affected in ADHD. Hence, pharmacological augmentation of parvalbumin- (PV) or somatostatin-positive (Sst) inhibitory ACC interneurons could be a potential treatment strategy. We, therefore, tested whether stimulation of Gq -protein-coupled receptors (Gq PCRs) in these interneurons could improve attention or impulsivity assessed with the 5-choice-serial reaction-time task in male mice...
July 5, 2023: Translational Psychiatry
https://read.qxmd.com/read/37405756/association-between-stimulant-treatment-and-substance-use-through-adolescence-into-early-adulthood
#22
JOURNAL ARTICLE
Brooke S G Molina, Traci M Kennedy, Andrea L Howard, James M Swanson, L Eugene Arnold, John T Mitchell, Annamarie Stehli, Edward H Kennedy, Jeffery N Epstein, Lily T Hechtman, Stephen P Hinshaw, Benedetto Vitiello
IMPORTANCE: Possible associations between stimulant treatment of attention-deficit/hyperactivity disorder (ADHD) and subsequent substance use remain debated and clinically relevant. OBJECTIVE: To assess the association of stimulant treatment of ADHD with subsequent substance use using the Multimodal Treatment Study of ADHD (MTA), which provides a unique opportunity to test this association while addressing methodologic complexities (principally, multiple dynamic confounding variables)...
July 5, 2023: JAMA Psychiatry
https://read.qxmd.com/read/37369587/mouse-behavior-on-the-trial-unique-nonmatching-to-location-tunl-touchscreen-task-reflects-a-mixture-of-distinct-working-memory-codes-and-response-biases
#23
JOURNAL ARTICLE
Daniel Bennett, Jay Nakamura, Chitra Vinnakota, Elysia Sokolenko, Jess Nithianantharajah, Maarten van den Buuse, Nigel C Jones, Suresh Sundram, Rachel Hill
The trial-unique nonmatching to location (TUNL) touchscreen task shows promise as a translational assay of working memory (WM) deficits in rodent models of autism, ADHD, and schizophrenia. However, the low-level neurocognitive processes that drive behavior in the TUNL task have not been fully elucidated. In particular, it is commonly assumed that the TUNL task predominantly measures spatial WM dependent on hippocampal pattern separation, but this proposition has not previously been tested. In this project, we tested this question using computational modeling of behavior from male and female mice performing the TUNL task ( N = 163 across three datasets; 158,843 trials)...
August 2, 2023: Journal of Neuroscience
https://read.qxmd.com/read/37312091/deep-psychophysiological-phenotyping-of-adolescents-and-adults-with-22q11-2-deletion-syndrome-a-multilevel-approach-to-defining-core-disease-processes
#24
JOURNAL ARTICLE
David A Parker, Joseph F Cubells, Sid L Imes, Gabrielle A Ruban, Brett T Henshey, Nicholas M Massa, Elaine F Walker, Erica J Duncan, Opal Y Ousley
BACKGROUND: 22q11.2 deletion syndrome (22q11.2DS) is the most common chromosomal interstitial-deletion disorder, occurring in approximately 1 in 2000 to 6000 live births. Affected individuals exhibit variable clinical phenotypes that can include velopharyngeal anomalies, heart defects, T-cell-related immune deficits, dysmorphic facial features, neurodevelopmental disorders, including autism, early cognitive decline, schizophrenia, and other psychiatric disorders. Developing comprehensive treatments for 22q11...
June 13, 2023: BMC Psychiatry
https://read.qxmd.com/read/37267092/individual-differences-adhd-diagnosis-and-driving-performance-effects-of-traffic-density-and-distraction-type
#25
JOURNAL ARTICLE
Alejandro A Arca, Mustapha Mouloua, P A Hancock
The present study examined the impact of individual differences, attention, and memory deficits on distracted driving. Drivers with ADHD are more susceptible to distraction which results in more frequent collisions, violations, and license suspensions. Consequently, the present investigation had thirty-six participants complete preliminary questionnaires, memory tasks, workload indices, and four, 4-minute simulated driving scenarios to evaluate such impact. It was hypothesized ADHD diagnosis, type of cellular distraction, and traffic density would each differentially and substantively impact driving performance...
June 2, 2023: Ergonomics
https://read.qxmd.com/read/37200782/an-escalating-continuum-of-learning-and-attention-difficulties-from-premutation-to-full-mutation-in-female-carriers-of-fmr1-expansion
#26
JOURNAL ARTICLE
Lidia V Gabis, Meirav Shaham, Odelia Leon Attia, Tamar Kowal, Sivan David, Yonit Banet-Levi, Shahar Shefer, Daniel Gabis, Dana Mula-Topf, Michal Avrech Bar, Orit Bart, Osnat Segal
OBJECTIVE: Carriers of Fragile X premutation may have associated medical comorbidities, such as Fragile X-associated tremor and ataxia (FXTAS) and Fragile X-associated premature ovarian insufficiency (FXPOI). We examined the Fragile X premutation effect on cognition, and we assumed that there is a direct correlation between the continuous spectrum of specific learning and attention deficits to the number of CGG repeats on the FMR1 gene. METHODS: A total of 108 women were referred to our center due to a related Fragile X syndrome (FXS) patient, 79 women carried a premutation of 56-199 repeats, and 19 women carried a full mutation of more than 200 CGG repeats on FMR1 gene...
2023: Frontiers in Neurology
https://read.qxmd.com/read/37066074/cerebellum-and-neurodevelopmental-disorders-ror%C3%AE-is-a-unifying-force
#27
JOURNAL ARTICLE
Svethna Ribeiro, Rachel M Sherrard
Errors of cerebellar development are increasingly acknowledged as risk factors for neuro-developmental disorders (NDDs), such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and schizophrenia. Evidence has been assembled from cerebellar abnormalities in autistic patients, as well as a range of genetic mutations identified in human patients that affect the cerebellar circuit, particularly Purkinje cells, and are associated with deficits of motor function, learning and social behavior; traits that are commonly associated with autism and schizophrenia...
2023: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/37034825/chronic-pain-and-psychiatric-conditions
#28
REVIEW
Keira J A Johnston, Laura M Huckins
INTRODUCTION: Chronic pain is a common condition with high socioeconomic and public health burden. A wide range of psychiatric conditions are often comorbid with chronic pain and chronic pain conditions, negatively impacting successful treatment of either condition. The psychiatric condition receiving most attention in the past with regard to chronic pain comorbidity has been major depressive disorder, despite the fact that many other psychiatric conditions also demonstrate epidemiological and genetic overlap with chronic pain...
2023: Complex psychiatry
https://read.qxmd.com/read/36963236/decision-making-and-frontoparietal-resting-state-functional-connectivity-among-impulsive-compulsive-diagnoses-insights-from-a-bayesian-approach
#29
JOURNAL ARTICLE
J J León, P Fernández-Martin, A González-Rodríguez, R Rodríguez-Herrera, J García-Pinteño, C Pérez-Fernández, A Sánchez-Kuhn, L Amaya-Pascasio, M Soto-Ontoso, P Martínez-Sánchez, F Sánchez-Santed, P Flores
The Iowa Gambling Task (IGT) is one of the most widely used paradigms for assessing decision-making. An impairment in this process may be linked to several psychopathological disorders, such as obsessive-compulsive disorder (OCD), substance abuse disorder (SUD) or attention-deficit/hyperactivity disorder (ADHD), which could make it a good candidate for being consider a transdiagnostic domain. Resting-state functional connectivity (rsFC) has been proposed as a promising biomarker of decision-making. In this study, we aimed to identify idiosyncratic decision-making profiles among healthy people and impulsive-compulsive spectrum patients during the IGT, and to investigate the role of frontoparietal network (FPN) rsFC as a possible biomarker of different decision-making patterns...
March 11, 2023: Addictive Behaviors
https://read.qxmd.com/read/36842882/additive-and-interactive-effects-of-attention-deficit-hyperactivity-disorder-and-tic-disorder-on-brain-connectivity
#30
JOURNAL ARTICLE
Joseph Jurgiel, Makoto Miyakoshi, Andrea Dillon, John Piacentini, Sandra K Loo
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) and persistent tic disorder (PTD) are two neurodevelopmental disorders that frequently co-occur. Contributions of each disorder to cognitive and behavioral deficits have been reported. In this paper, we tested 3 models of pathophysiology for the two disorders (additive, interactive, and phenotypic) using resting-state connectivity associated with each disorder separately and together. METHODS: Participants were 148 children (55 with ADHD only, 33 with ADHD and PTD, 27 with PTD only, and 33 healthy control subjects) at ages 8 to 12 years...
October 28, 2022: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/36778635/age-related-clinical-characteristics-of-children-and-adolescents-with-adhd
#31
JOURNAL ARTICLE
Pietro De Rossi, Barbara D'Aiello, Italo Pretelli, Deny Menghini, Silvia Di Vara, Stefano Vicari
INTRODUCTION: Attention deficit hyperactivity disorder (ADHD) has been associated with difficulties in regulating aversion states, high functional impairment, and a high risk of psychopathology across the lifespan. ADHD is clinically heterogeneous, with a wide spectrum of severity and associated symptoms. Clinical characteristics need to be carefully defined in different periods of life as ADHD course, symptoms, and comorbidities may fluctuate and change over time. Adolescence usually represents the transition from primary to secondary education, with a qualitative and quantitative change in environmental and functional demands, thus driving symptoms' change...
2023: Frontiers in Psychiatry
https://read.qxmd.com/read/36670616/maximizing-quality-of-life-in-children-with-epilepsy
#32
JOURNAL ARTICLE
Yu-Tze Ng
Arguably significant progress and improvement in the medical and surgical treatments of seizures and epilepsy in children have occurred; however, there have been relatively fewer efforts in optimizing the care of lifestyle complications related to the disease state. Many patients have significant behavioral and mental health comorbidities, including ADHD (attention deficit hyperactivity disorder), which should be treated. After epilepsy surgery, only seizure freedom results in improved quality of life (QOL)...
December 28, 2022: Children
https://read.qxmd.com/read/36525524/driving-under-the-influence-of-amphetamine-analytical-evaluation-of-illegal-or-prescription-drug-intake-using-chiral-uhplc-ms-ms
#33
JOURNAL ARTICLE
Marie Katrine Klose Nielsen, Nina Zacho Andersen, Brian Schou Rasmussen, Sys Stybe Johansen
Differentiation between consumption of illegal and prescription drugs remains an important aspect in forensic toxicology. While illicit amphetamine is most often racemic, the medicinal drugs marketed in Denmark for the treatment of attention deficit hyperactivity disorder (ADHD) contains the pure (S)-enantiomer or a prodrug thereof. In this study, we present a simple and efficient analytical workflow to provide information about the origin of amphetamine consumed in forensic cases concerning driving under the influence of drugs (DUID)...
December 16, 2022: Journal of Analytical Toxicology
https://read.qxmd.com/read/36449421/trial-of-training-to-reduce-driver-inattention-in-teens-with-adhd
#34
RANDOMIZED CONTROLLED TRIAL
Jeffery N Epstein, Annie A Garner, Adam W Kiefer, James Peugh, Leanne Tamm, Ryan P MacPherson, John O Simon, Donald L Fisher
BACKGROUND: Teens with attention deficit-hyperactivity disorder (ADHD) are at increased risk for motor vehicle collisions. A computerized skills-training program to reduce long glances away from the roadway, a contributor to collision risk, may ameliorate driving risks among teens with ADHD. METHODS: We evaluated a computerized skills-training program designed to reduce long glances (lasting ≥2 seconds) away from the roadway in drivers 16 to 19 years of age with ADHD...
December 1, 2022: New England Journal of Medicine
https://read.qxmd.com/read/36205208/mental-health-and-driving-behaviour-of-students-and-alumni-of-a-university-in-the-united-arab-emirates-a-cross-sectional-study
#35
JOURNAL ARTICLE
Gabriel Andrade, Dalia Bedawi, Ibrahim Bani
Background: The United Arab Emirates has set the goal to reduce traffic-related deaths to 3 per 100 000 people by 2021. To do this, authorities must assess the factors related to risky driving behaviour. Aims: To verify if there are any correlations between driving behaviour and certain variables, including years of driving experience, daily hours of sleep, general markers of mental health, and symptoms of attention deficit hyperactivity disorder (ADHD). Methods: Two hundred and seventy-five participants responded to a survey made up of the Manchester driver behaviour questionnaire, the general health questionnaire, the adult ADHD self-report scale, and 2 additional questions...
September 29, 2022: Eastern Mediterranean Health Journal
https://read.qxmd.com/read/36174249/adhd-and-dangerous-driving-in-emerging-adults-the-moderating-role-of-family-climate-for-road-safety
#36
JOURNAL ARTICLE
Austin B Burns, Annie A Garner, Amina Avion, Stephen P Becker, Michael J Kofler, Matthew A Jarrett, Aaron M Luebbe, G Leonard Burns
Dangerous driving accounts for 95% of driving fatalities among emerging adults. Emerging adult drivers exhibiting symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD) are at greater risk for motor vehicle crashes and engaging in unsafe driving practices; however, not all individuals with ADHD symptoms exhibit such risk. Several studies have found that drivers' perceptions of their family's values and priorities related to driving practices predict driving outcomes among emerging adults; these factors have not been examined in the context of ADHD symptomology...
December 2022: Accident; Analysis and Prevention
https://read.qxmd.com/read/36163277/identification-of-shared-and-differentiating-genetic-architecture-for-autism-spectrum-disorder-attention-deficit-hyperactivity-disorder-and-case-subgroups
#37
JOURNAL ARTICLE
Manuel Mattheisen, Jakob Grove, Thomas D Als, Joanna Martin, Georgios Voloudakis, Sandra Meier, Ditte Demontis, Jaroslav Bendl, Raymond Walters, Caitlin E Carey, Anders Rosengren, Nora I Strom, Mads Engel Hauberg, Biao Zeng, Gabriel Hoffman, Wen Zhang, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Esben Agerbo, Bru Cormand, Merete Nordentoft, Thomas Werge, Ole Mors, David M Hougaard, Joseph D Buxbaum, Stephen V Faraone, Barbara Franke, Søren Dalsgaard, Preben B Mortensen, Elise B Robinson, Panos Roussos, Benjamin M Neale, Mark J Daly, Anders D Børglum
Attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are highly heritable neurodevelopmental conditions, with considerable overlap in their genetic etiology. We dissected their shared and distinct genetic etiology by cross-disorder analyses of large datasets. We identified seven loci shared by the disorders and five loci differentiating them. All five differentiating loci showed opposite allelic directions in the two disorders and significant associations with other traits, including educational attainment, neuroticism and regional brain volume...
October 2022: Nature Genetics
https://read.qxmd.com/read/36152341/ecological-validity-of-executive-function-tests-in-predicting-driving-performance
#38
JOURNAL ARTICLE
Heshmatollah Ghawami, Jaleh Homaei Shoaa, Mona Moazenzadeh, Minoo Sorkhavandi, Atiyeh Okhovvat, Neda Hadizadeh, Marjan Yamola, Vafa Rahimi-Movaghar
Almost all of our everyday activities depend on executive function (EF) skills. In line with the increasing attention to the ecological validation of neuropsychological assessment and intervention methods, this study aimed to explore the ecological validity of a relevant set of widely used EF tests, mostly from well-known paradigms of EF assessment, in predicting driving ability. Ninety-six healthy novice drivers ( M age  = 26.2 years, SD  = 8.4; 48 female) completed four stages of our data collection including psychological, EF, and driving assessments...
September 24, 2022: Applied Neuropsychology. Adult
https://read.qxmd.com/read/36031250/mental-health-conditions-and-unsafe-driving-behaviors-a-naturalistic-driving-study-on-adhd-and-depression
#39
JOURNAL ARTICLE
Ou Stella Liang, Christopher C Yang
INTRODUCTION: Road injuries remain a persistent public health concern across the world. The task of driving is complicated by mental health conditions, which may affect drivers' executive functioning and cognitive resource allocation. This study examines whether attention-deficit/hyperactivity disorder (ADHD) and depression are associated with unsafe driving behaviors. METHOD: Generalized linear mixed models were employed to estimate the association of self-reported ADHD and depression with 18 unsafe driving behavior types found prior to at-fault crashes and near-crashes using a large-scale naturalistic driving dataset...
September 2022: Journal of Safety Research
https://read.qxmd.com/read/36006496/autism-spectrum-disorder-and-attention-deficit-hyperactivity-disorder-shared-or-unique-neurocognitive-profiles
#40
JOURNAL ARTICLE
Russell J Schachar, Annie Dupuis, Paul D Arnold, Evdokia Anagnostou, Elizabeth Kelley, Stelios Georgiades, Robert Nicolson, Parker Townes, Christie L Burton, Jennifer Crosbie
Attention-deficit/hyperactivity (ADHD) and autism spectrum (ASD) disorders are commonly co-occurring conditions characterized by neurocognitive impairments. Few studies have directly compared neurocognitive profiles in ADHD and ASD and fewer still have controlled for comorbidity of ADHD and ASD. All direct comparisons have been in clinic samples, leaving the question of generalizability of results unaddressed. We compared neurocognitive performance in clinically ascertained ASD (n = 261) and ADHD (n = 423) cases and controls (n = 162), 6...
August 25, 2022: Research on child and adolescent psychopathology
keyword
keyword
21860
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.