Manuel Mattheisen, Jakob Grove, Thomas D Als, Joanna Martin, Georgios Voloudakis, Sandra Meier, Ditte Demontis, Jaroslav Bendl, Raymond Walters, Caitlin E Carey, Anders Rosengren, Nora I Strom, Mads Engel Hauberg, Biao Zeng, Gabriel Hoffman, Wen Zhang, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Esben Agerbo, Bru Cormand, Merete Nordentoft, Thomas Werge, Ole Mors, David M Hougaard, Joseph D Buxbaum, Stephen V Faraone, Barbara Franke, Søren Dalsgaard, Preben B Mortensen, Elise B Robinson, Panos Roussos, Benjamin M Neale, Mark J Daly, Anders D Børglum
Attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are highly heritable neurodevelopmental conditions, with considerable overlap in their genetic etiology. We dissected their shared and distinct genetic etiology by cross-disorder analyses of large datasets. We identified seven loci shared by the disorders and five loci differentiating them. All five differentiating loci showed opposite allelic directions in the two disorders and significant associations with other traits, including educational attainment, neuroticism and regional brain volume...
October 2022: Nature Genetics