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Toxoplasmosis

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https://www.readbyqxmd.com/read/29788193/ocular-toxoplasmosis-adverse-reactions-to-treatment-in-a-brazilian-cohort
#1
Lusiele Guaraldo, Bianca Balzano de la Fuente Villar, Nicolle Marins Gomes Durão, Virgínia Clare Louro, Marcel de Souza Borges Quintana, André Luiz Land Curi, Elizabeth Souza Neves
Background: The purpose of this study was to estimate the frequency and describe the adverse drug reactions (ADRs) associated with the classic treatment of ocular toxoplasmosis (OT), namely sulfadiazine, pyrimethamine, corticosteroids and folinic acid. Methods: We performed a descriptive study of a prospective cohort of patients with OT treated with the classic therapy. Data were collected during medical consultations and treatment. Results: Of the 147 patients studied, 85% developed one or more ADR...
May 19, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29780938/management-of-giant-retinal-tear-and-retinal-detachment-in-a-patient-with-active-toxoplasmosis-retinochoroiditis
#2
Nathan L Scott, Jayanth Sridhar, Harry W Flynn
Purpose: To describe the management of a giant retinal tear with retinal detachment in a patient with active toxoplasmosis retinochoroiditis. Results: While receiving systemic medications for toxoplasmosis, the patient underwent scleral buckling, pars plana vitrectomy, and C3F8 gas tamponade without removal of the lens. At last follow-up, best corrected visual acuity was 20/20 with an attached retina and the toxoplasmosis lesion was inactive. Conclusions: and Importance: Using modern surgical techniques, anatomic and clinical success is possible during active retinochoroiditis...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29779048/increased-il-27-il-27r-expression-in-association-with-the-immunopathology-of-murine-ocular-toxoplasmosis
#3
Xinxin Tong, Shengjie Chen, Huanqin Zheng, Shiguang Huang, Fangli Lu
Interleukin 27 (IL-27) is a member of the IL-6/IL-12 family, and IL-27 receptor (IL-27R) consists of WSX-1 (the IL-27Rα subunit) and the signal-transducing subunit gp130. Human and mouse mast cells (MCs) express the IL-27R. To explore the expressions of IL-27/IL-27R subunits (WSX-1 and gp130) during acute ocular toxoplasmosis (OT), we established mouse model by intraocular injection of 500 Toxoplasma gondii RH strain tachyzoites. Histopathological changes were analyzed, MCs were counted by toluidine blue staining, and tryptase+ /IL-27+ MCs were examined by immunofluorescence double-staining in the eyes and cervical lymph nodes (CLNs) of T...
May 19, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29772049/mild-bilateral-hemorrhagic-occlusive-retinal-vasculitis-following-intracameral-vancomycin-administration-in-cataract-surgery
#4
Sruthi Arepalli, Yasha S Modi, Ryan Deasy, Sunil K Srivastava
A patient underwent cataract surgery with prophylactic intracameral vancomycin (Vancocin; Pfizer, New York City, NY) in each eye, 2 weeks apart. Four weeks after, the patient presented with a mild bilateral hemorrhagic occlusive retinal vasculitis (HORV). A systemic work-up was negative for syphilis, toxoplasmosis, Bartonella, tuberculosis, and sarcoidosis. The patient was treated with oral steroids and one intravitreal steroid injection in the left eye. Ten months after presentation, the patient's vasculitis was quiescent...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29769499/toxoplasma-gondii-seropositivity-and-its-possible-associated-risk-factors-among-pregnant-women-attending-antenatal-clinic-in-a-tertiary-care-hospital-of-dhaka-bangladesh
#5
C R Naheen, S Tarafder, S Khan
Toxoplasmosis is a well-documented cause of bad obstetric history (BOH) and a major reason of congenitally acquired infection. This observational study was conducted to detect the rate of seropositivity of toxoplasmosis in pregnant women and observe their risk factors associated with disease transmission attending the antenatal clinic of the Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from July 2015 to August 2016. The study subjects included 150 pregnant women of different gestational ages...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29765610/x-ray-and-cryo-em-structures-of-inhibitor-bound-cytochrome-bc-1-complexes-for-structure-based-drug-discovery
#6
Kangsa Amporndanai, Rachel M Johnson, Paul M O'Neill, Colin W G Fishwick, Alexander H Jamson, Shaun Rawson, Stephen P Muench, S Samar Hasnain, Svetlana V Antonyuk
Cytochrome bc 1 , a dimeric multi-subunit electron-transport protein embedded in the inner mitochondrial membrane, is a major drug target for the treatment and prevention of malaria and toxoplasmosis. Structural studies of cytochrome bc 1 from mammalian homologues co-crystallized with lead compounds have underpinned structure-based drug design to develop compounds with higher potency and selectivity. However, owing to the limited amount of cytochrome bc 1 that may be available from parasites, all efforts have been focused on homologous cytochrome bc 1 complexes from mammalian species, which has resulted in the failure of some drug candidates owing to toxicity in the host...
March 1, 2018: IUCrJ
https://www.readbyqxmd.com/read/29762364/seroprevalence-of-toxoplasma-gondii-infection-among-%C3%AE-thalassemia-major-pediatric-population-implications-for-transfusion-transmissible-toxoplasmosis
#7
Nora El-Tantawy, Ahmad Darwish, Eman Eissa
BACKGROUND: Children with β-thalassemia major who regularly receive blood transfusion are at risk of developing transfusion-transmitted infection. Toxoplasmosis is a common and a serious parasitic disease with high prevalence and could be transmitted through blood transfusion from healthy asymptomatic donors. However, screening Toxoplasma gondii before blood donation has not been considered. OBJECTIVE: To determine the prevalence of T. gondii antibodies among thalassemia children undergoing blood transfusion...
May 14, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29753341/human-parasitology-and-parasitic-diseases-heading-towards-2050
#8
Peter J Hotez
By 2050 our civilized planet may be comprised predominantly of networked megacities embedded in warm subtropical and tropical climates, and under stress from climate change and catastrophic weather events. Urban slum areas in these cities, including those found in wealthier middle- and high-income nations (blue marble health), will be especially vulnerable to disease. Moreover, regional conflicts fought over shifting and limited resources, including water, will collapse health systems infrastructures to further promote disease emergence and reemergence...
2018: Advances in Parasitology
https://www.readbyqxmd.com/read/29750191/structures-of-monomeric-and-oligomeric-forms-of-the-toxoplasma-gondii-perforin-like-protein-1
#9
Tao Ni, Sophie I Williams, Saša Rezelj, Gregor Anderluh, Karl Harlos, Phillip J Stansfeld, Robert J C Gilbert
Toxoplasma and Plasmodium are the parasitic agents of toxoplasmosis and malaria, respectively, and use perforin-like proteins (PLPs) to invade host organisms and complete their life cycles. The Toxoplasma gondii PLP1 ( Tg PLP1) is required for efficient exit from parasitophorous vacuoles in which proliferation occurs. We report structures of the membrane attack complex/perforin (MACPF) and Apicomplexan PLP C-terminal β-pleated sheet (APCβ) domains of Tg PLP1. The MACPF domain forms hexameric assemblies, with ring and helix geometries, and the APCβ domain has a novel β-prism fold joined to the MACPF domain by a short linker...
March 2018: Science Advances
https://www.readbyqxmd.com/read/29749872/secondary-prophylaxis-of-toxoplasmosis-in-pregnancy-in-an-hiv-positive-woman
#10
Subathira Dakshina, Robert F Miller, Cheuk Yw Tong, Liat Sarner
A 39-year-old HIV-positive black African woman with previously treated cerebral toxoplasmosis experienced a foetal intra-uterine death due to congenital toxoplasmosis. This case demonstrates the complexities of screening for maternal toxoplasmosis in the context of pregnancy and HIV infection-related cell-mediated immunosuppression. Additionally, the case highlights the challenges in providing effective preventative and therapeutic drug options for congenital toxoplasmosis.
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29748456/a-systematic-review-and-meta-analysis-of-the-prevalence-of-toxoplasmosis-in-hemodialysis-patients-in-iran
#11
Masoud Foroutan, Ali Rostami, Hamidreza Majidiani, Seyed Mohammad Riahi, Sasan Khazaei, Milad Badri, Elham Yousefi
Objectives: Toxoplasmosis is a worldwide distributed parasitic disease with wide range of complications in immunocompromised patients. This systematic review and meta-analysis study was performed to evaluate the seroprevalence of Toxoplasma gondii (T. gondii) among patients undergoing hemodialysis patients in Iran. Methods: We searched the English and Persian databases for studies reporting T. gondii seroprevalence in Iranian hemodialysis patients up to 31 December 2017...
April 23, 2018: Epidemiology and Health
https://www.readbyqxmd.com/read/29747388/evaluation-of-anti-toxoplasma-gondii-effect-of-ursolic-acid-as-a-novel-toxoplasmosis-inhibitor
#12
Won Hyung Choi, In Ah Lee
This study was carried out to evaluate the anti-parasitic effect of ursolic acid against Toxoplasma gondii ( T. gondii ) that induces toxoplasmosis, particularly in humans. The anti-parasitic effects of ursolic acid against T. gondii -infected cells and T. gondii were evaluated through different specific assays, including immunofluorescence staining and animal testing. Ursolic acid effectively inhibited the proliferation of T. gondii when compared with sulfadiazine, and consistently induced anti- T. gondii activity/effect...
May 9, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29742869/serologic-tests-of-igg-and-igm-antibodies-and-igg-avidity-for-diagnosis-of-ocular-toxoplasmosis
#13
Bahman Rahimi-Esboei, Mohammad Zarei, Mehdi Mohebali, Hossein Keshavarz Valian, Saeedeh Shojaee, Raziyeh Mahmoudzadeh, Mirataollah Salabati
This prospective study was aimed to detect acute and chronic ocular toxoplasmosis by comparison of anti- Toxoplasma gondii IgM and IgG antibody levels and IgG avidity test. One hundred and seventeen patients with ocular toxoplasmosis (OT) who referred to the Farabi Eye Hospital, Tehran, Iran were included in this study. Of the patients, 77 cases were positive for anti- T. gondii IgG, and 8 cases were positive for anti- T. gondii IgM. IgG avidity test revealed 11, 4, and 102 cases were low, intermediate, and high, respectively, and 6...
April 2018: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29737953/gadolinium-distribution-in-cerebrospinal-fluid-after-administration-of-a-gadolinium-based-mr-contrast-agent-in-humans
#14
Florian Berger, Rahel A Kubik-Huch, Tilo Niemann, Hans Ruedi Schmid, Michael Poetzsch, Johannes M Froehlich, Jürg H Beer, Michael J Thali, Thomas Kraemer
Purpose To evaluate whether gadolinium penetrates human cerebrospinal fluid (CSF) after MR imaging (MRI) with a gadolinium-based contrast agent (GBCA). Materials and Methods For this retrospective study, the authors analyzed 60 CSF samples from 57 patients (median age, 50 years; range, 3-92 years) who underwent one contrast material-enhanced MRI examination with gadoterate meglumine within 60 days of CSF extraction between January and December 2016. CSF samples from patients who underwent MRI without contrast material administration (n = 22) or those who underwent contrast-enhanced MRI at least 1 year before extraction (n = 2) were analyzed and used as control samples...
May 8, 2018: Radiology
https://www.readbyqxmd.com/read/29737440/detection-of-toxoplasma-specific-immunoglobulin-g-in-human-sera-performance-comparison-of-in-house-dot-elisa-with-eclia-and-elisa
#15
Aref Teimouri, Mohammad Hossein Modarressi, Saeedeh Shojaee, Mehdi Mohebali, Nima Zouei, Mostafa Rezaian, Hossein Keshavarz
In the current study, performance of electrochemiluminescence immunoassay (ECLIA) in detection of anti-toxoplasma IgG in human sera was compared with that of enzyme-linked immunosorbent assay (ELISA). Furthermore, performance of an in house Dot-ELISA in detection of anti-toxoplasma IgG was compared with that of ECLIA and ELISA. In total, 219 human sera were tested to detect anti-toxoplasma IgG using Dynex DS2® and Roche Cobas® e411 Automated Analyzers. Discordant results rechecked using immunofluorescence assay (IFA)...
May 8, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29731568/toxoplasmosis-submandibular-lymphadenitis-report-of-an-unusual-case-with-a-brief-review
#16
Susmita Saxena, Sanjeev Kumar, Jitin Kharbanda
A 16-year-old male patient reported with swelling of the right submandibular region for 3 months. The patient was asymptomatic and gave a history of fever lasting for 2 days before observing the swelling. Fine-needle aspiration cytology revealed nonspecific lymphadenitis, and since there was no apparent cause detected in the oral cavity or any systemic condition noted, the enlarged lymph node was surgically excised and submitted for histopathologic examination. The inflammatory condition and large numbers of macrophages appeared nonspecific while granuloma formation was not seen...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29719641/patterns-of-uveitis-at-a-tertiary-referral-center-in-northeastern-iran
#17
Seyedeh Maryam Hosseini, Nasser Shoeibi, Raheleh Ebrahimi, Mehdi Ghasemi
Purpose: To describe the demographic and clinical patterns of patients with uveitis referred to a tertiary center in northeastern Iran. Methods: This cross-sectional retrospective study included 235 patients with uveitis who had been referred to the uveitis clinic of Khatam-Al-Anbia eye hospital, affiliated to Mashhad University of Medical Sciences, from February 2013 to March 2014. Data regarding patient age, sex, anatomical location of the disease, and etiologic and clinical features were analyzed...
April 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29718996/transcriptional-repression-by-apiap2-factors-is-central-to-chronic-toxoplasmosis
#18
Joshua B Radke, Danielle Worth, David Hong, Sherri Huang, William J Sullivan, Emma H Wilson, Michael W White
Tachyzoite to bradyzoite development in Toxoplasma is marked by major changes in gene expression resulting in a parasite that expresses a new repertoire of surface antigens hidden inside a modified parasitophorous vacuole called the tissue cyst. The factors that control this important life cycle transition are not well understood. Here we describe an important transcriptional repressor mechanism controlling bradyzoite differentiation that operates in the tachyzoite stage. The ApiAP2 factor, AP2IV-4, is a nuclear factor dynamically expressed in late S phase through mitosis/cytokinesis of the tachyzoite cell cycle...
May 2, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29717769/prognostic-significance-of-microsatellite-instability%C3%A2-associated-pathways-and-genes-in-gastric-cancer
#19
Xiaosheng Hang, Dapeng Li, Jianping Wang, Ge Wang
The aim of the present study was to reveal the potential molecular mechanisms of microsatellite instability (MSI) on the prognosis of gastric cancer (GC). The investigation was performed based on an RNAseq expression profiling dataset downloaded from The Cancer Genome Atlas, including 64 high‑level MSI (MSI‑H) GC samples, 44 low‑level MSI (MSI‑L) GC samples and 187 stable microsatellite (MSI‑S) GC samples. Differentially expressed genes (DEGs) were identified between the MSI‑H, MSI‑L and MSI‑S samples...
April 26, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29717641/eastern-equine-encephalitis-in-puppies-in-michigan-and-new-york-states
#20
Caroline Andrews, Jodie Gerdin, Jon Patterson, Elizabeth L Buckles, Scott D Fitzgerald
Eastern equine encephalitis virus (EEEV) is classified as a select agent and is capable of causing mortality in humans and a number of veterinary species. Herein, we describe 3 cases of EEE in puppies in Michigan and New York. Two puppies were euthanized following an acute history of seizures and obtundation. A littermate of one of these puppies died 2 wk earlier following a history of anorexia and fever. All 3 puppies lacked significant gross anatomic lesions at autopsy and tested negative for rabies virus...
April 1, 2018: Journal of Veterinary Diagnostic Investigation
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