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https://www.readbyqxmd.com/read/28641165/identifying-seizure-clusters-in-patients-with-psychogenic-nonepileptic-seizures
#1
Grayson L Baird, Lisa L Harlow, Jason T Machan, Dave Thomas, W Curt LaFrance
The present study explored how seizure clusters may be defined for those with psychogenic nonepileptic seizures (PNES), a topic for which there is a paucity of literature. The sample was drawn from a multisite randomized clinical trial for PNES; seizure data are from participants' seizure diaries. Three possible cluster definitions were examined: 1) common clinical definition, where ≥3 seizures in a day is considered a cluster, along with two novel statistical definitions, where ≥3 seizures in a day are considered a cluster if the observed number of seizures statistically exceeds what would be expected relative to a patient's: 1) average seizure rate prior to the trial, 2) observed seizure rate for the previous seven days...
June 19, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28633044/written-accounts-of-living-with-psychogenic-nonepileptic-seizures-a-thematic-analysis
#2
Gregg H Rawlings, Ian Brown, Brendan Stone, Markus Reuber
PURPOSE: Qualitative studies examining lived experiences of psychogenic nonepileptic seizures (PNES) have predominantly relied on datasets collected using clinical or research interviews. This study pursued a different approach by investigating individuals' written accounts of their condition. METHODS: Participants (n=19) were recruited from membership-led organisations for individuals living with seizures and from a United Kingdom hospital. Participants were instructed to produce four pieces of writing: 1) about their thoughts and feelings about their condition; 2) a letter to their condition; 3) a letter to their younger self; and 4) about a personal value...
June 15, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28624511/cluster-reduction-in-patients-in-a-pilot-treatment-trial-for-psychogenic-nonepileptic-seizures
#3
Grayson L Baird, Lisa L Harlow, Jason T Machan, W Curt LaFrance
INTRODUCTION: The present study examined seizure clusters as a primary outcome in patients receiving treatment for PNES. Cluster reduction is examined longitudinally using frequency threshold and statistical definitions of seizure cluster for patients. Possible risk factors for clustering will be examined along with clustering as a risk factor for poorer secondary outcomes. METHODS: Participants were from a pilot randomized treatment trial for PNES where they received cognitive behavioral therapy-informed psychotherapy (CBT-ip), sertraline, combination therapy, or treatment as usual...
June 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28622545/diagnosing-psychogenic-nonepileptic-seizures-video-eeg-monitoring-suggestive-seizure-induction-and-diagnostic-certainty
#4
Stoyan Popkirov, Johannes Jungilligens, Wenke Grönheit, Jörg Wellmer
Psychogenic nonepileptic seizures (PNES) can remain undiagnosed for many years, leading to unnecessary medication and delayed treatment. A recent report by the International League Against Epilepsy Nonepileptic Seizures Task Force recommends a staged approach to the diagnosis of PNES (LaFrance, et al., 2013). We aimed to investigate its practical utility, and to apply the proposed classification to evaluate the role of long-term video-EEG monitoring (VEEG) and suggestive seizure induction (SSI) in PNES workup...
June 13, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28618331/psychogenic-nonepileptic-seizures-namibian-healthcare-providers-perceptions-and-frustrations
#5
Anina du, Toit, Chrisma Pretorius
PURPOSE: Most studies conducted on the diagnosis and treatment of psychogenic nonepileptic seizures (PNES) have been performed in developed countries with developing countries, such as Namibia, receiving less attention. This study aimed to contribute to the aims of The International League against Epilepsy Psychogenic Nonepileptic Seizure Task Force by investigating the perceptions and frustrations of healthcare providers (HCPs) in Namibia regarding the diagnosis and treatment of psychogenic nonepileptic seizures...
June 9, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28614746/ictal-coughing-clinical-features-and-differential-diagnoses
#6
Ali A Asadi-Pooya, Leah Shabo, Dale Wyeth, Maromi Nei
PURPOSE: To describe a series of patients with ictal coughing to estimate its occurrence and characterize the clinical features and differential diagnoses. METHODS: We retrospectively reviewed all the long-term video-EEG reports from Jefferson Comprehensive Epilepsy Center over a 7-year period (2010-2016) for the occurrence of the term "cough" in the text body. All the extracted reports were reviewed and patients with at least one documented ictal coughing at the epilepsy monitoring unit (EMU) were included in the study...
June 11, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28611548/hippocampal-characteristics-and-invariant-sequence-elements-distribution-of-glra2-and-glra3-c-to-u-editing
#7
Philipp Schaefermeier, Sarah Heinze
Glycine receptor α2 and α3 subunit (GLRA2/GLRA3) high-affinity variants, of which the subjacent amino acid substitutions issue from C-to-U RNA editing, are thought to influence tonic inhibition and pathophysiology. In light of the detection of GLRA3 NM_006529:r.1157C>U and GLRA2 NM_002063:r.1416C>U exchanges in hippocampus explants of temporal lobe epilepsy patients, we now examine the healthy situation and relate it to the epileptic situation by ascertaining controls in a legitimate reanalysis. The GLRA2 and GLRA3 editing events that would ultimately result in a glycine receptor with increased affinity occur in the postmortem nonepileptic hippocampus...
March 2017: Molecular Syndromology
https://www.readbyqxmd.com/read/28606495/personality-traits-in-psychogenic-nonepileptic-seizures-pnes-and-psychogenic-movement-disorder-pmd-neuroticism-and-perfectionism
#8
Vindhya Ekanayake, Sarah Kranick, Kathrin LaFaver, Arshi Naz, Anne Frank Webb, W Curt LaFrance, Mark Hallett, Valerie Voon
OBJECTIVE: Psychogenic movement disorder (PMD) and psychogenic nonepileptic seizures (PNES) are two subtypes of conversion disorder (CD). In this case-control study, we asked whether these subtypes varied as a function of personality and history of childhood abuse. METHODS: Fifty-nine patients with PMD from the Human Motor Control Section Clinic at the National Institutes of Health, 43 patients with PNES from the Rhode Island Hospital Neuropsychiatry and Behavioral Neurology Division, and 26 healthy volunteers (HC) received a battery of neurological, psychiatric and psychological assessments, including the NEO Personality Inventory Revised (NEO PI-R), the Childhood Trauma Questionnaire (CTQ), and the Traumatic Life Events Questionnaire (TLEQ)...
June 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28605633/epileptic-vs-psychogenic-nonepileptic-seizures-a-video-based-survey
#9
Danielle Wasserman, Moshe Herskovitz
Psychogenic non epileptic seizures (PNES) are present in up to 30% of patients undergoing video EEG. Delay in PNES diagnosis is an average of 7.2years. Patients are exposed to costly, hazardous medications and other iatrogenic morbidities. Our aim was to investigate the ability to correctly diagnose ES from PNES in different groups and seniorities of medical professionals based on video alone. We showed ten video episodes' recordings (5 PNES, 5 ES) to doctors and nurses from ER, Internal Medicine ward and Neurology department, and inquired about the episodes' nature...
June 9, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28586436/response-to-the-letter-regarding-the-impact-of-psychogenic-nonepileptic-seizures-and-our-seizure-assessment-tool
#10
Edward K Avila
No abstract text is available yet for this article.
June 6, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28557750/incidence-and-prevalence-of-childhood-epilepsy-a-nationwide-cohort-study
#11
Kari Modalsli Aaberg, Nina Gunnes, Inger Johanne Bakken, Camilla Lund Søraas, Aleksander Berntsen, Per Magnus, Morten I Lossius, Camilla Stoltenberg, Richard Chin, Pål Surén
BACKGROUND AND OBJECTIVES: Epilepsy affects 0.5% to 1% of children and is the most frequent chronic neurologic condition in childhood. Incidence rates appear to be declining in high-income countries. The validity of epilepsy diagnoses from different data sources varies, and contemporary population-based incidence studies are needed. METHODS: The study was based on the Norwegian Mother and Child Cohort Study. Potential epilepsy cases were identified through registry linkages and parental questionnaires...
May 2017: Pediatrics
https://www.readbyqxmd.com/read/28557061/classification-of-involuntary-movements-in-dogs-myoclonus-and-myotonia
#12
REVIEW
M Lowrie, L Garosi
Myoclonus is a sudden brief, involuntary muscle jerk. Of all the movement disorders, myoclonus is the most difficult to encapsulate into any simple framework. On the one hand, a classification system is required that is clinically useful to aid in guiding diagnosis and treatment. On the other hand, there is need for a system that organizes current knowledge regarding biological mechanisms to guide scientific research. These 2 needs are distinct, making it challenging to develop a robust classification system suitable for all purposes...
May 30, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28555877/synergistic-protection-against-acute-flurothyl-induced-seizures-by-adjuvant-treatment-of-the-ketogenic-diet-with-the-type-2-diabetes-drug-pioglitazone
#13
Timothy A Simeone, Stephanie A Matthews, Kristina A Simeone
OBJECTIVE: We have previously found that the transcription factor peroxisome proliferator-activated receptor γ (PPARγ) contributes to the mechanism of action of the ketogenic diet (KD), an established treatment for pediatric refractory epilepsy. We have found that the KD increases brain PPARγ and that inhibition or genetic loss of PPARγ prevents the antiseizure effects of the KD on (1) acutely induced seizures in nonepileptic mice and (2) spontaneous recurrent seizures in epileptic mice...
May 28, 2017: Epilepsia
https://www.readbyqxmd.com/read/28529525/melatonin-in-tuberous-sclerosis-complex-analysis-using-modern-mathematical-modeling-methods
#14
Justyna Paprocka, Marek Kijonka, Łukasz Boguszewicz, Maria Sokół
Purpose. The aim of the study was to assess melatonin secretion pattern in children with TSC and to compare it with the secretion patterns in children with and without epilepsy. Material and Methods. Melatonin secretion was measured every three hours using the RIA method in four children with recognized TSC. The parameters of the melatonin secretion models were interpreted and compared with those obtained for the patients with epilepsy (n = 76) and the children from the control, nonepileptic group (n = 36)...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28520630/diagnostic-yield-of-routine-electroencephalography-with-concurrent-video-recording-in-detecting-interictal-epileptiform-discharges-in-relation-to-reasons-for-request-a-prospective-study-of-1-080-video-electroencephalograms
#15
Laia Grau-López, Marta Jiménez, Jordi Ciurans, Sonia Barambio, Alejandra Fumanal, Juan L Becerra
PURPOSE: The aim of this study was to prospectively analyze the sensitivity and specificity of routine electroencephalography with concurrent video recording (vEEG) in relation to the reasons for requesting the test and to investigate when routine vEEG should be requested. METHODS: We prospectively analyzed 1,080 consecutive vEEGs performed between April 2015 and April 2016. The requests for vEEG were classified as requests with a low suspicion of epilepsy (syncope, confusion or delirium, suspicion of psychogenic nonepileptic seizures, and paroxysmal focal neurological deficit) or requests with a high suspicion of epilepsy (first clinical seizure, suspected status epilepticus, follow-up study of a patient with epilepsy, and acute symptomatic seizures)...
May 16, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28501288/recurrent-episodes-of-brief-global-amnesia-related-to-intrathecal-baclofen-pump-originally-mistaken-for-psychogenic-nonepileptic-seizures
#16
David Rosenblum, Gulam Noorani, Paul H Desan
No abstract text is available yet for this article.
March 16, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28464309/psychiatric-and-behavioral-comorbidities-in-epilepsy-a-critical-reappraisal
#17
REVIEW
Anne T Berg, Hamada H Altalib, Orrin Devinsky
Psychiatric and behavioral disorders are important aspects of epilepsy and have received increasing attention in the last several years. The literature upon which most of the field relies contains some biases that must be carefully examined and resolved in future studies. First, in the pediatric epilepsy literature, many reports find that children with epilepsy have high levels of behavioral and psychiatric disorders when compared to appropriate controls. Most of these studies rely on parent-proxy completed instruments to assess these behavioral endpoints...
May 2, 2017: Epilepsia
https://www.readbyqxmd.com/read/28427027/multisensory-temporal-function-and-eeg-complexity-in-patients-with-epilepsy-and-psychogenic-nonepileptic-events
#18
Jean-Paul Noel, LeAnne Kurela, Sarah H Baum, Hong Yu, Joseph S Neimat, Martin J Gallagher, Mark Wallace
Cognitive and perceptual comorbidities frequently accompany epilepsy and psychogenic nonepileptic events (PNEE). However, and despite the fact that perceptual function is built upon a multisensory foundation, little knowledge exists concerning multisensory function in these populations. Here, we characterized facets of multisensory processing abilities in patients with epilepsy and PNEE, and probed the relationship between individual resting-state EEG complexity and these psychophysical measures in each patient...
May 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28427022/stereotypy-of-psychogenic-nonepileptic-seizures
#19
Moshe Herskovitz
Psychogenic nonepileptic seizures (PNES) are defined as paroxysmal episodes in which epileptic semiology features are manifested, without the characteristic concomitant electrical discharges seen in epileptic seizures. Although many studies have dealt with semiologic classification of PNES, most of the studies did not raise the question of consistency of PNES in the same patient. The aim of this study was to measure the degree of consistency of PNES among individual patients. We retrospectively reviewed medical records and video- EEG records of all adult patients who underwent monitoring in our center from August 1st 2013 to May 31st 2015...
May 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28371670/panic-symptoms-in-transient-loss-of-consciousness-frequency-and-diagnostic-value-in-psychogenic-nonepileptic-seizures-epilepsy-and-syncope
#20
G H Rawlings, J Jamnadas-Khoda, M Broadhurst, R A Grünewald, S J Howell, M Koepp, S W Parry, S M Sisodiya, M C Walker, M Reuber
PURPOSE: Previous studies suggest that ictal panic symptoms are common in patients with psychogenic nonepileptic seizures (PNES). This study investigates the frequency of panic symptoms in PNES and if panic symptoms, just before or during episodes, can help distinguish PNES from the other common causes of transient loss of consciousness (TLOC), syncope and epilepsy. METHODS: Patients with secure diagnoses of PNES (n=98), epilepsy (n=95) and syncope (n=100) were identified using clinical databases from three United Kingdom hospitals...
March 27, 2017: Seizure: the Journal of the British Epilepsy Association
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