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https://www.readbyqxmd.com/read/29309953/facial-emotion-processing-in-patients-with-seizure-disorders
#1
Jerzy P Szaflarski, Jane B Allendorfer, Rodolphe Nenert, W Curt LaFrance, Helen I Barkan, Jennifer DeWolfe, Sandipan Pati, Ashley E Thomas, Lawrence Ver Hoef
Studies of emotion processing are needed to better understand the pathophysiology of psychogenic nonepileptic seizures (PNES). We examined the differences in facial emotion processing between 12 patients with PNES, 12 patients with temporal lobe epilepsy (TLE), and 24 matched healthy controls (HCs) using fMRI with emotional faces task (EFT) (happy/sad/fearful/neutral) and resting state connectivity. Compared with TLE, patients with PNES exhibited increased fMRI response to happy, neutral, and fearful faces in visual, temporal, and/or parietal regions and decreased fMRI response to sad faces in the putamen bilaterally...
January 5, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29283181/loss-of-constitutive-functional-%C3%AE-aminobutyric-acid-type-a-b-receptor-crosstalk-in-layer-5-pyramidal-neurons-of-human-epileptic-temporal-cortex
#2
Katiuscia Martinello, Miriam Sciaccaluga, Roberta Morace, Addolorata Mascia, Antonietta Arcella, Vincenzo Esposito, Sergio Fucile
OBJECTIVE: γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in adult central nervous system, and profound alterations of GABA receptor functions are linked to temporal lobe epilepsy (TLE). Here we describe the functional relationships between GABA receptors type B (GABAB R) and type A (GABAA R) in human temporal cortex and how TLE affects this aspect of GABAergic signaling. METHODS: Miniature inhibitory postsynaptic currents (mIPSCs) were recorded by patch-clamp techniques from human L5 pyramidal neurons in slices from temporal cortex tissue obtained from surgery...
December 28, 2017: Epilepsia
https://www.readbyqxmd.com/read/29239801/psychogenic-nonepileptic-seizures-a-disconnect-between-body-and-mind
#3
EDITORIAL
Gholam K Motamedi
No abstract text is available yet for this article.
November 24, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29218816/long-term-adherence-with-psychiatric-treatment-among-patients-with-psychogenic-nonepileptic-seizures
#4
Benjamin Tolchin, Barbara A Dworetzky, Gaston Baslet
We conducted a prospective cohort study, examining long-term adherence with psychiatric treatment among patients with psychogenic nonepileptic seizures (PNES). Subjects diagnosed with documented PNES were scheduled for 4 psychiatric visits. Survival analysis was performed, and covariates were assessed for association with time to nonadherence using Cox proportional hazard regression analysis. One hundred twenty-three subjects were recruited and followed for up to 17 months. Eighty percent of subjects attended the first outpatient visit, 42% attended the second, 24% attended the third, and only 14% remained adherent through the fourth visit...
December 7, 2017: Epilepsia
https://www.readbyqxmd.com/read/29215453/generalized-periodic-discharges-with-and-without-triphasic-morphology
#5
Ayham M Alkhachroum, Haifa Al-Abri, Alok Sachdeva, Sarita Maturu, Jennifer Waldron, Han Wang, Macym Rizvi, Guadalupe Fernandez-Baca Vaca, Hans O Lüders
PURPOSE: Generalized periodic discharges (GPDs) with a triphasic morphology have been associated with nonepileptic encephalopathies. We conducted the study to assess the reliability in which electroencephalographers can differentiate triphasic from nontriphasic periodic discharges and to evaluate for the presence of electroencephalogram and clinical characteristics that are associated with a higher risk of seizures. METHODS: We studied prospectively 92 patients between May 2016 and February 2017...
November 27, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/29204018/role-of-biomarkers-in-differentiating-new-onset-seizures-from-psychogenic-nonepileptic-seizures
#6
Mahendra Javali, Purushottam Acharya, Shripal Shah, Rohan Mahale, Pushparaja Shetty, Srinivasa Rangasetty
Introduction: Review of literature revealed very limited studies considering a combination of serum prolactin (PRL) and serum creatine kinase (CK) as markers for differentiating epileptic and psychogenic nonepileptic seizures (PNES). Therefore, in the present study, we analyzed the role of serum PRL and serum CK, individually and in combination. Methodology: This prospective study was conducted in a tertiary care medical teaching hospital over a period of 18 months...
October 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29184354/carbamazepine-induced-seizure-in-a-nonepileptic-child
#7
Rajesh Benny, Vyankatesh Bolegave, Sameer Sadavarte, Vinayak Khatav
No abstract text is available yet for this article.
October 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29183659/are-there-gender-differences-in-those-diagnosed-with-psychogenic-nonepileptic-seizures
#8
Lorna Myers, Robert Trobliger, Kirsty Bortnik, Marcelo Lancman
OBJECTIVE: The objective of the study was to determine whether male and female populations of patients with psychogenic nonepileptic seizures (PNES) differ, in terms of demographic, social/clinical, and etiological factors as well as psychological measures. BACKGROUND: Psychogenic nonepileptic seizures are overrepresented by females; therefore, information about PNES in males is limited. Only a handful of studies have examined PNES and gender, and of those, one was a literature review and with the exception of two, most have had small sample sizes...
November 25, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29175222/temporal-lobe-asymmetry-in-fdg-pet-uptake-predicts-neuropsychological-and-seizure-outcomes-after-temporal-lobectomy
#9
Janina Kamm, Laura L Boles Ponto, Ken Manzel, Owen J Gaasedelen, Yasunori Nagahama, Taylor Abel, Daniel Tranel
OBJECTIVE: The objective of this study was to determine whether preoperative [18F]fludeoxyglucose (FDG)-positron emission tomography (PET) asymmetry in temporal lobe metabolism predicts neuropsychological and seizure outcomes after temporal lobectomy (TL). METHODS: An archival sample of 47 adults with unilateral temporal lobe epilepsy who underwent TL of their language-dominant (29 left, 1 right) or nondominant (17 right) hemisphere were administered neuropsychological measures pre- and postoperatively...
January 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29173224/occupational-therapy-for-functional-neurological-disorders-a-scoping-review-and-agenda-for-research
#10
Paula Gardiner, Lindsey MacGregor, Alan Carson, Jon Stone
Functional neurological disorders (FND)-also called psychogenic, nonorganic, conversion, and dissociative disorders-constitute one of the commonest problems in neurological practice. An occupational therapist (OT) is commonly involved in management, but there is no specific literature or guidance for these professionals. Classification now emphasizes the importance of positive diagnosis of FND based on physical signs, more than psychological features. Studies of mechanism have produced new clinical and neurobiological ways of thinking about these disorders...
November 27, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/29157502/pediatric-psychogenic-nonepileptic-seizures-a-concise-review
#11
REVIEW
Julia L Doss, Sigita Plioplys
Psychogenic nonepileptic seizures is a complicated biopsychosocial disorder with significant morbidity and high cost in children's social, emotional, family, and academic functioning as well as health care service utilization. Misdiagnosis and diagnostic delay, resulting from both lack of access to approved standards for diagnosing and service providers comfortable with diagnosing and treating this disorder, impact prognosis. Treatment in close proximity to symptom onset is thought to provide the best chance for remission...
January 2018: Child and Adolescent Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/29152734/access-to-diagnostic-and-therapeutic-facilities-for-psychogenic-nonepileptic-seizures-an-international-survey-by-the-ilae-pnes-task-force-2nd-revision
#12
Coraline Hingray, Wissam El-Hage, Rod Duncan, David Gigineishvili, Kousuke Kanemoto, W Curt LaFrance, Alejandro de Marinis, Ravi Paul, Chrisma Pretorius, José F Téllez Zenteno, Hannah Wiseman, Markus Reuber
OBJECTIVE: Studies from a small number of countries suggest that patients with psychogenic nonepileptic seizures (PNES) have limited access to diagnostic and treatment services. The PNES Task Force of the International League Against Epilepsy (ILAE) carried out 2 surveys to explore the diagnosis and treatment of PNES around the world. METHODS: A short survey (8 questions) was sent to all 114 chapters of the ILAE. A longer survey (36 questions) was completed by healthcare professionals who see patients with seizures...
November 20, 2017: Epilepsia
https://www.readbyqxmd.com/read/29132064/patients-and-caregivers-contributions-for-differentiating-epileptic-from-psychogenic-nonepileptic-seizures-value-and-limitations-of-self-reporting-questionnaires-a-pilot-study
#13
Giuseppe Erba, Elisa Bianchi, Giorgia Giussani, John Langfitt, Adam Juersivich, Ettore Beghi
PURPOSE: Questionnaires investigating semiology and comorbidities of psychogenic non-epileptic seizures (PNES) have been used mainly to help physicians expedite referrals to epilepsy centres for confirmation of diagnosis rather than as alternative diagnostic tool when video-EEG monitoring (VEM), the current gold standard, is not available or is inconclusive. METHODS: We developed one structured questionnaire for patients, exploring subjective experiences and vulnerabilities and one for eyewitnesses, focused on features observable during typical events to study prospectively 50 consecutive adult patients with PNES or epileptic seizures (ES) admitted for VEM...
November 8, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29126048/lennox-gastaut-syndrome-in-adulthood-long-term-clinical-follow-up-of-38-patients-and-analysis-of-their-recorded-seizures
#14
Aglaia Vignoli, Gaia Oggioni, Giovanni De Maria, Angela Peron, Miriam Nella Savini, Elena Zambrelli, Valentina Chiesa, Francesca La Briola, Katherine Turner, Maria Paola Canevini
Lennox-Gastaut syndrome (LGS) is a severe epileptic encephalopathy with childhood onset that usually continues through adolescence and into adulthood. In the long term, patients with this condition still have intractable seizures, intellectual disability, behavioral problems, and physical comorbidities. The aim of this study was to describe the clinical and EEG characteristics of a group of adults with Lennox-Gastaut syndrome. We identified 38 (22 females, 16 males) patients with LGS older than age 18years at their last evaluation, with mean age of 43...
November 7, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29111503/are-the-clinical-classifications-for-psychogenic-nonepileptic-seizures-reliable
#15
Coline Duwicquet, Bertrand de Toffol, Philippe Corcia, Maxime Bonnin, Wissam El-Hage, Julien Biberon
BACKGROUND: Psychogenic nonepileptic seizures (PNESs) are episodes that resemble epileptic seizures but are of psychological origin. A few studies have attempted to describe different types of PNES as a combination of clinical signs but their validation and robustness have not yet been reached. The aim of this study was to assess the inter-rater reliability (IRR) of five existing clinical PNES classifications. METHODS: A total of 107 PNESs from 54 patients were retrospectively analyzed independently by two trained epileptologists, who were blinded to each other's findings...
October 27, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29111502/a-simple-clinical-score-for-prediction-of-nonepileptic-seizures
#16
Sindhu R Rao, Jeremy D Slater, Giridhar P Kalamangalam
Psychogenic nonepileptic seizures (PNES), often mistaken for epilepsy in community practice, require inpatient video-EEG (VEEG) monitoring for diagnostic confirmation. We developed a simple score designed for use in an outpatient setting to predict the subsequent VEEG diagnosis of PNES. We retrospectively compared fifty-five consecutive patients with VEEG-proven PNES (N1=55) with a group of randomly selected patients with VEEG-proven epilepsy (N2=55). Patients were divided into two groups: I) a 'truly retrospective' group of 27 patients with PNES and 27 patients with epilepsy whose data served to develop the score, and II) a 'pseudoprospective' group of 28 patients each with PNES and epilepsy to whom the score was applied...
December 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29111501/understanding-variability-in-driving-recommendations-for-patients-with-seizures
#17
Sidrah Mahmud, Sean T Hwang
BACKGROUND: There is lack of consensus regarding driving restrictions for patients with epilepsy. Regulations vary by state. New York State (NYS) recommends driving restrictions for one year in a person with an episode of loss of consciousness (LOC), with physician discretion. Often, providers make recommendations to permit their patients to drive after a shorter seizure-free period than proposed guidelines. The prevalence and reasons behind more lenient recommendations have not been elucidated...
October 27, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29099440/postnatal-expression-of-thalamic-gabaa-receptor-subunits-in-the-stargazer-mouse-model-of-absence-epilepsy
#18
Steve Seo, Beulah Leitch
Absence seizures are known to originate from disruptions within the corticothalamocortical network; however, the precise underlying cellular and molecular mechanisms that induce hypersynchronicity and hyperexcitability are debated and likely to be complex and multifactorial. Recent studies implicate impaired thalamic GABAergic inhibition as a common feature in multiple animal models of absence epilepsy, including the well-established stargazer mouse model. Recently, we demonstrated region-specific increases in the whole tissue and synaptic levels of GABAA receptor (GABAAR) subunits α1 and β2, within the ventral posterior region of the thalamus in adult epileptic stargazer mice compared with nonepileptic control littermates...
December 13, 2017: Neuroreport
https://www.readbyqxmd.com/read/29095389/paroxysmal-tonic-upgaze-in-children-three-case-reports-and-a-review-of-the-literature
#19
Ayse Kartal
BACKGROUND: In clinical practice, nonepileptic paroxysmal events during infancy and childhood are common reasons for parents and caregivers to seek for medical advice. These events are mostly unrecognized and considered as an epileptic seizure because of the clinical features resembling an epileptic seizure. Paroxysmal tonic upgaze, which consists of recurrent episodes of sustained upward deviation of the eyes and incomplete downward saccades, and normal horizontal eye movements without impairment of consciousness, is a diagnostic challenge for the pediatrician and pediatric neurologist...
October 31, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29092782/psychopathological-constellation-in-patients-with-pnes-a-new-hypothesis
#20
Iolanda Martino, Antonella Bruni, Angelo Labate, Roberta Vasta, Antonio Cerasa, Giuseppe Borzì, Pasquale De Fazio, Antonio Gambardella
Depression symptoms have often reported in patients with psychogenic nonepileptic seizures (PNES), although the underlying psychopathological symptomatology has been poorly understood. Our aim was to compare constellations of psychological and behavioral disturbance in PNES with respect to patients with mild-major depressive disorder (MDD), hypothesizing that the construct of depression might be different in the two groups. Ten patients with PNES and ten sex-/age-matched patients with mild-MDD newly-diagnosed, were enrolled in this study...
October 29, 2017: Epilepsy & Behavior: E&B
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