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https://www.readbyqxmd.com/read/28934706/untreated-hypertension-as-predictor-of-in-hospital-mortality-in-intracerebral-hemorrhage-a-multi-center-study
#1
Mario Hevesi, Eric M Bershad, Mostafa Jafari, Stephan A Mayer, Magdy Selim, Jose I Suarez, Afshin A Divani
PURPOSE: Hypertension is a significant risk factor for intracerebral hemorrhage (ICH). The importance of managing blood pressure to reduce the risk of ICH has been recognized. However, few studies have focused on ICH outcomes due to untreated hypertension. MATERIALS AND METHODS: We conducted a 5-year, retrospective, multicenter study of 490 consecutive ICH patients with histories of untreated-hypertension (n=56), treated-hypertension (n=314), and normotension (n=120)...
September 6, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28931362/dual-antiplatelet-therapy-is-associated-with-coagulopathy-detectable-by-thrombelastography-in-acute-stroke
#2
Mark M McDonald, Tareq S Almaghrabi, Daniel M Saenz, Chunyan Cai, Mohammad H Rahbar, H Alex Choi, Kiwon Lee, James C Grotta, Tiffany R Chang
BACKGROUND: Thrombelastography (TEG) provides a global, dynamic measure of coagulation. We examined the effect of antiplatelet (AP) medications on coagulation in patients with acute stroke as measured by TEG. METHODS: We reviewed prospectively collected data on patients presenting with acute ischemic stroke (AIS) and spontaneous intracerebral hemorrhage (ICH) between 2009 and 2014. Patient demographics and baseline TEG values were compared among 4 different drug use groups: aspirin only, clopidogrel only, both aspirin and clopidogrel, and no AP...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28931255/initial-single-center-technical-experience-with-the-brainpath-system-for-acute-intracerebral-hemorrhage-evacuation
#3
Andrew M Bauer, Peter A Rasmussen, Mark D Bain
BACKGROUND: Surgical intervention has been proposed as a means of reducing the high morbidity and mortality associated with acute intracerebral hemorrhage (ICH), but many previously reported studies have failed to show a clinically significant benefit. Newer, minimally invasive approaches have shown some promise. OBJECTIVE: We report our early single-center technical experience with minimally invasive clot evacuation using the BrainPath system. METHODS: Prospective data were collected on patients who underwent ICH evacuation with BrainPath at the Cleveland Clinic from August 2013 to May 2015...
February 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28929560/minocycline-and-matrix-metalloproteinase-inhibition-in-acute-intracerebral-hemorrhage-a-pilot-study
#4
J J Chang, M Kim-Tenser, B A Emanuel, G M Jones, K Chapple, A Alikhani, N Sanossian, W J Mack, G Tsivgoulis, A V Alexandrov, T Pourmotabbed
BACKGROUND AND PURPOSE: Intracerebral hemorrhage (ICH) is a devastating cerebrovascular disorder with high morbidity and mortality. Minocycline is a matrix metalloproteinase-9 (MMP-9) inhibitor that may attenuate secondary mechanisms of injury in ICH. The feasibility and safety of minocycline in ICH patients were evaluated in a pilot, double-blinded, placebo-controlled randomized clinical trial. METHODS: Patients with acute onset (<12 h from symptom onset) ICH and small initial hematoma volume (<30 ml) were randomized to high-dose (10 mg/kg) intravenous minocycline or placebo...
September 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28928459/neutrophil-polarization-by-il-27-as-a-therapeutic-target-for-intracerebral-hemorrhage
#5
Xiurong Zhao, Shun-Ming Ting, Chin-Hsuan Liu, Guanghua Sun, Marian Kruzel, Meaghan Roy-O'Reilly, Jaroslaw Aronowski
Shortly after intracerebral hemorrhage, neutrophils infiltrate the intracerebral hemorrhage-injured brain. Once within the brain, neutrophils degranulate, releasing destructive molecules that may exacerbate brain damage. However, neutrophils also release beneficial molecules, including iron-scavenging lactoferrin that may limit hematoma/iron-mediated brain injury after intracerebral hemorrhage. Here, we show that the immunoregulatory cytokine interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage...
September 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28926188/minimal-factor-xiii-activity-level-to-prevent-major-spontaneous-bleeds-reply
#6
M Menegatti, R Palla, P Bucciarelli, F Peyvandi
We thank Dr. Dorgalaleh et al. for their interest in our report regarding the minimal Factor XIII (FXIII) activity level to prevent major spontaneous bleedings [1] and for describing their experience using a low dose prophylaxis in patients with severe FXIII deficiency [2]. As reported by the authors, primary prophylaxis is mandatory for all patients with severe congenital FXIII deficiency, since the diagnosis, to prevent spontaneous life-threatening bleeding. It is well known that the main cause of death or disability in these patients is intracranial haemorrhage (ICH), occurring either spontaneously or after minor trauma, therefore an early prophylaxis is crucial [3]...
September 19, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28925725/light-sensitive-drugs-in-topical-formulations-stability-indicating-methods-and-photostabilization-strategies
#7
Giuseppina Ioele, Lorena Tavano, Michele De Luca, Rita Muzzalupo, Annalisa Mancuso, Gaetano Ragno
Photostability tests applied on commercial specialties for topical use have demonstrated a greater vulnerability of several drugs, due to greater exposure to light than other pharmaceutical forms. Photodegradation of a drug can considerably modify its pharmacokinetic behavior by varying the therapeutic index. The evaluation of the degradation profile of a drug, according to the ICH rules, is of primary importance in developing an appropriate topical formulation. Advanced strategies have been proposed to increase the protection from the light of the photolabile drugs...
September 19, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28922640/a-novel-spectroscopic-analysis-to-detect-photochemical-reaction-of-the-bronchodilator-doxofylline-and-its-estimation-in-pharmaceutical-formulation
#8
P Sasi Rekha, S Gunasekaran
Photostability studies of drugs and drug products are an integral part of the product development process in the pharmaceutical industry. These studies are carried out to ensure quality, efficacy and safety of the formulated products during manufacture, storage and use. In this investigation, a novel spectroscopic approach has been adopted by employing the FTIR-ATR and UV/Visible techniques to detect the photochemical reactions of the drug Doxofylline, chemically designated as 7-(1, 3 dioxolane-2-yl methyl) theophylline, in its raw (pure) form...
September 11, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28921914/comparison-of-relation-between-multiple-parameters-of-glycemic-variability-and-coronary-plaque-vulnerability-assessed-by-virtual-histology-intravascular-ultrasound
#9
Natsu Otowa-Suematsu, Kazuhiko Sakaguchi, Hisako Komada, Tomoaki Nakamura, Anna Sou, Yushi Hirota, Masaru Kuroda, Toshiro Shinke, Ken-Ich Hirata, Wataru Ogawa
AIMS/INTRODUCTION: Increased glycemic variability is an important contributing factor to coronary artery disease. Although various parameters of glycemic variability can be derived by continuous glucose monitoring, the clinical relevance of individual parameters has remained unclear. We have now analyzed the relation of such parameters to coronary plaque vulnerability MATERIALS AND METHODS: The standard deviation of glucose levels (SD glucose), mean amplitude of glycemic excursions (MAGE), continuous overlapping net glycemic action calculated every 1 h (CONGA-1), and mean of daily differences (MODD) were calculated from continuous glucose monitoring data for 53 subjects hospitalized for percutaneous coronary intervention...
September 16, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28920538/fibrinolytic-for-treatment-of-intraventricular-hemorrhage-a-meta-analysis-and-systematic-review
#10
Alexandra Delaney Baker, Krissia Margarita Rivera Perla, Zhiyuan Yu, Rachel Dlugash, Radhika Avadhani, William Andrew Mould, Wendy Ziai, Richard E Thompson, Dimitre Staykov, Daniel F Hanley
Background Intraventricular hemorrhage is a significant cause of mortality and morbidity worldwide. Treating intraventricular hemorrhage with intraventricular fibrinolytic therapy via a catheter is becoming an increasingly utilized intervention. Aims This meta-analysis aimed to investigate the role of intraventricular fibrinolytic treatment in hypertensive intraventricular hemorrhage patients and evaluate the effect sizes for survival as well as level of function at differing time points. Summary of review PubMed, CNKI, VIP, and Wanfang were searched using the terms "IVH" and "IVH and ICH" for human studies with adult patients published between January 1950 and July 2016...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28916863/intracerebral-hemorrhage-as-a-manifestation-of-cerebral-hyperperfusion-syndrome-after-carotid-revascularization-systematic-review-and-meta-analysis
#11
REVIEW
Pedro Abreu, Jerina Nogueira, Filipe Brogueira Rodrigues, Ana Nascimento, Mariana Carvalho, Ana Marreiros, Hipólito Nzwalo
BACKGROUND: Intracerebral hemorrhage (ICH) in the context of cerebral hyperperfusion syndrome (CHS) is an uncommon but potentially lethal complication after carotid revascularization for carotid occlusive disease. Information about its incidence, risk factors and fatality is scarce. Therefore, we aimed to perform a systematic review and meta-analysis focusing on the incidence, risk factors and outcomes of ICH in the context of CHS after carotid revascularization. METHODS: We searched the PubMed and EBSCO hosts for all studies published in English about CHS in the context of carotid revascularization...
September 15, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28915688/neutrophil-to-lymphocyte-ratio-and-neurological-deterioration-following-acute-cerebral-hemorrhage
#12
Simona Lattanzi, Claudia Cagnetti, Leandro Provinciali, Mauro Silvestrini
Immunity plays key roles in pathophysiology of intracerebral hemorrhage (ICH). The aim of the study was to determine whether the peripheral leukocyte count and neutrophil-to-lymphocyte ratio (NLR) predicted neurological deterioration (ND) after ICH. We identified consecutive patients with ICH who had blood sampling performed within 24 hours from symptom's onset. Total white blood cells (WBC), absolute neutrophil count (ANC) and absolute lymphocyte count (ALC) were retrieved, and the NLR computed as the ratio of the ANC to ALC values...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28913708/emergency-neurological-life-support-intracerebral-hemorrhage
#13
J Claude Hemphill, Arthur Lam
Intracerebral hemorrhage (ICH) is a subset of stroke due to spontaneous bleeding within the parenchyma of the brain. It is potentially lethal, and survival depends on ensuring an adequate airway, proper diagnosis, and early management of several specific issues such as blood pressure, coagulopathy reversal, and surgical hematoma evacuation for appropriate patients. ICH was chosen as an Emergency Neurological Life Support (ENLS) protocol because intervention within the first hours may improve outcome, and it is critical to have site-specific protocols to drive care quickly and efficiently...
September 14, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28911660/an-ecofriendly-green-liquid-chromatographic-method-for-simultaneous-determination-of-nicotinamide-and-clindamycin-phosphate-in-pharmaceutical-gel-for-acne-treatment
#14
Fawzia Ibrahim, Asmaa Kamal El-Deen, Samah Abo El Abass, Kuniyoshi Shimizu
A new green micellar liquid chromatographic method was developed and validated for the quantitative estimation of nicotinamide (NICO) and clindamycin phosphate (CLD) in bulk and pharmaceutical gel formulation. The analytes are well resolved in less than 6.0 minutes using micellar mobile phase consisting of 0.10M sodium dodecyl sulfate (SDS), 0.3% triethylamine, and 10% 2-propanol in 0.02M orthophosphoric acid at pH 3.0, running through an Eclipse XDB-C8 column (150 mm×4.6 mm, 5 μm particle size) with flow rate 1...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28911654/extraction-optimization-of-gallic-acid-catechin-%C3%A2-procyanidin-b2-epicatechin-epigallocatechin-gallate-and-epicatechin-gallate-their-simultaneous-identification-and-quantification-in-saraca-asoca
#15
Tushar Dhanani, Raghuraj Singh, Satyanshu Kumar
The objective of the present investigation was to optimize extraction conditions for maximum recovery of bioactive phenolics from different parts of Saraca asoca. Extraction recovery was optimized using a mixture of methanol and water in different proportions. For identification and quantification of six analytes, a rapid reversed phase ultra-performance liquid chromatography (UPLC) photo diode array detection method was developed. UPLC separation was achieved in a gradient elution mode on a C18 column with acetonitrile and aqueous phosphoric acid (0...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28906578/ultra-early-hematoma-growth-in-antithrombotic-pretreated-patients-with-intracerebral-hemorrhage
#16
Jaume Roquer, Rosa María Vivanco-Hidalgo, Jaume Capellades, Angel Ois, Elisa Cuadrado-Godia, Eva Giralt-Steinhauer, Carolina Soriano-Tárraga, Marina Mola-Caminal, Maria Serra-Martínez, Carla Avellaneda-Gómez, Jordi Jiménez-Conde, Ana Rodríguez-Campello
BACKGROUND: Patients with acute intracerebral hemorrhage (ICH) pretreated with antithrombotic drugs may have increased early hematoma growth, which would increase mortality risk. We analyzed the effect of antiplatelet (AP) and vitamin-K antagonist (VKA) pretreatment on ultra-early hematoma growth (uHG), and its relationship with mortality in patients with acute supratentorial ICH. METHODS: This is an observational retrospective study of a prospective register of 197 ICH patients with first computed tomography (CT) scan taken less than 6 hours from ICH symptoms onset...
September 14, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28905241/photostability-issues-in-pharmaceutical-dosage-forms-and-photostabilization
#17
REVIEW
Karthik Yadav Janga, Tamara King, Nan Ji, Sandeep Sarabu, Gauri Shadambikar, Sagar Sawant, Pengchong Xu, Michael A Repka, S Narasimha Murthy
Photodegradation is one of the major pathways of the degradation of drugs. Some therapeutic agents and excipients are highly sensitive to light and undergo significant degradation, challenging the quality and the stability of the final product. The adequate knowledge of photodegradation mechanisms and kinetics of photosensitive therapeutic entities or excipients is a pivotal aspect in the product development phase. Hence, various pharmaceutical regulatory agencies, across the world, mandated the industries to assess the photodegradation of pharmaceutical products from manufacturing stage till storage, as per the guidelines given in the International Conference on Harmonization (ICH)...
September 13, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28903833/resolution-and-quantitation-of-triamcinolone-acetonide-and-its-coformulated-drug-in-the-presence-of-its-impurities-and-degradation-products-by-hptlc-and-hplc
#18
Samah S Abbas, Maha A Hegazy, Hassan A M Hendawy, Soheir A Weshahy, May H Abdelwahab
Two specific, sensitive, and precise stability-indicating chromatographic methods have been developed for thedetermination of triamcinolone acetonide (TMC) and its coformulated drug, econazole nitrate (ECZ), in the presence of TMC impurities and degradation products. The first method was based on HPTLC-spectrodensitometry in which resolution and quantitation was achieved by using silica gel 60 F254 HPTLC plates and an ethyl acetate–tetrahydrofuran–ammonia mobile phase (10.0 + 7.0 + 0.1, v/v/v)...
September 14, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28901996/intracranial-hemorrhage-in-congenital-bleeding-disorders
#19
Shadi Tabibian, Hoda Motlagh, Majid Naderi, Akbar Dorgalaleh
: Intracranial hemorrhage (ICH), as a life-threatening bleeding among all kinds of congenital bleeding disorders (CBDs), is a rare manifestation except in factor XIII (FXIII) deficiency, which is accompanied by ICH, early in life, in about one-third of patients. Most inherited platelet function disorders (IPFDs) are mild to moderate bleeding disorders that can never experience a severe bleeding as in ICH; however, Glanzmann's thrombasthenia, a common and severe inherited platelet function disorder, can lead to ICH and occasional death...
September 9, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28901462/role-of-ghrelin-in-small-intestinal-motility-following-pediatric-intracerebral-hemorrhage-in-mice
#20
Jieyu Zan, Lei Song, Jiejie Wang, Rong Zou, Fei Hong, Jinhua Zhao, Yijun Cheng, Ming Xu
Small intestinal motility (SIM) disorder is a common complication following pediatric intracerebral hemorrhage (ICH), leading to a poor prognosis in patients. Previous studies have shown that ghrelin is involved in SIM in various diseases; however, the role of ghrelin in pediatric ICH‑induced SIM disorder remains to be elucidated. The present study was designed to investigate the association between ghrelin and SIM post‑ICH, and to examine the effect of exogenous ghrelin administration on SIM in vivo...
September 12, 2017: Molecular Medicine Reports
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