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Collagen crosslinking

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https://www.readbyqxmd.com/read/29779627/in-vitro-assessment-of-ribose-modified-two-step-etch-and-rinse-dentine-adhesive
#1
U Daood, J K H Tsoi, P Neelakantan, J P Matinlinna, H A K Omar, M Al-Nabulsi, A S Fawzy
OBJECTIVE: Collagen fibrils aid in anchoring resin composite restorations to the dentine substrate. The aim of the study was to investigate effect of non-enzymatic glycation on bond strength and durability of demineralized dentine specimens in a modified two-step etch-and-rinse dentine adhesive. METHODS: Dentine surfaces were etched with 37% phosphoric acid, bonded with respective in vitro ethanol and acetone adhesives modified with (m/m, 0, 1%, 2% and 3% ribose), restored with restorative composite-resin, and sectioned into resin-dentine slabs and beams to be stored for 24h or 12 months in artificial saliva...
May 17, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29777678/uva-riboflavin-collagen-crosslinking-stiffening-effects-on-anterior-and-posterior-corneal-flaps
#2
Hamed Hatami-Marbini, Sandeep M Jayaram
The UVA/riboflavin collagen crosslinking (CXL) is one of the treatment procedure for stopping the progression of keratoconus. The inclusion criterion for this procedure is a minimum corneal thickness of 400 μm, which is not often met in patients with advanced keratoconus. Preoperatively swelling of thin corneas was shown to stabilize the keratectasia without any postoperative endothelial damage. Recently, we have shown that swelling porcine corneas prior to the CXL treatment had no significant effect on the resulting improvement in their tensile properties...
May 16, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29771883/-transepithelial-corneal-collagen-crosslinking-in-patients-with-progressive-keratoconus
#3
A I Kopaenko, N V Ivanova
PURPOSE: To assess the effectiveness of transepithelial collagen crosslinking (CXL) in patients with keratoconus. MATERIAL AND METHODS: The study involved 44 patients (44 eyes) with stage I-II progressive keratoconus. Patients were divided into two groups. The 1st group included 22 patients that had underwent transepithelial CXL. The 2nd group included 22 patients that had underwent traditional CXL. RESULTS AND DISCUSSION: All patients of the group 2 all patients had corneal syndrome, which lasted 2-4 days...
2018: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29763670/goodpasture-s-autoimmune-disease-a-collagen-iv-disorder
#4
REVIEW
Vadim Pedchenko, A Richard Kitching, Billy G Hudson
Goodpasture's (GP) disease is an autoimmune disorder characterized by the deposition of pathogenic autoantibodies in basement membranes of kidney and lung eliciting rapidly progressive glomerulonephritis and pulmonary hemorrhage. The principal autoantigen is the α345 network of collagen IV, which expression is restricted to target tissues. Recent discoveries include a key role of chloride and bromide for network assembly, a novel posttranslational modification of the antigen, a sulfilimine bond that crosslinks the antigen, and the mechanistic role of HLA in genetic susceptibility and resistance to GP disease...
May 12, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29759420/lysyl-oxidase-like-2-contributes-to-renal-fibrosis-in-col4%C3%AE-3-alport-mice
#5
Dominic Cosgrove, Brianna Dufek, Daniel T Meehan, Duane Delimont, Michael Hartnett, Gina Samuelson, Michael Anne Gratton, Grady Phillips, Deidre A MacKenna, Gretchen Bain
Lysyl oxidase like-2 (LOXL2) is an amine oxidase with both intracellular and extracellular functions. Extracellularly, LOXL2 promotes collagen and elastin crosslinking, whereas intracellularly, LOXL2 has been reported to modify histone H3, stabilize SNAIL, and reduce cell polarity. Although LOXL2 promotes liver and lung fibrosis, little is known regarding its role in renal fibrosis. Here we determine whether LOXL2 influences kidney disease in COL4A3 (-/-) Alport mice. These mice were treated with a small molecule inhibitor selective for LOXL2 or with vehicle and assessed for glomerular sclerosis and fibrosis, albuminuria, blood urea nitrogen, lifespan, pro-fibrotic gene expression and ultrastructure of the glomerular basement membrane...
May 11, 2018: Kidney International
https://www.readbyqxmd.com/read/29757239/preparation-physicochemical-and-antioxidant-properties-of-acid-and-pepsin-soluble-collagens-from-the-swim-bladders-of-miiuy-croaker-miichthys-miiuy
#6
Wen-Hao Zhao, Chang-Feng Chi, Yu-Qin Zhao, Bin Wang
Collagen is one of the most useful biomaterials and widely applied in functional food and cosmetics. However, some consumers have paid close attention to the safety of mammalian collagens because of the outbreaks of bovine spongiform encephalopathy (BSE), foot-and-mouth disease (FMD), and other prion diseases. Therefore, there is a strong demand for developing alternative sources of collagen, with one promising source being from the process by-products of commercial fisheries. In this report, acid-soluble collagen (ASC-SB) and pepsin-soluble collagen (PSC-SB) from swim bladders of miiuy croaker ( Miichthys miiuy ) were isolated with yields of 1...
May 12, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29755969/evaluation-of-fluorine-18-labeled-%C3%AE-1-i-n-telopeptide-analogs-as-substrate-based-radiotracers-for-pet-imaging-of-melanoma-associated-lysyl-oxidase
#7
Manuela Kuchar, Christin Neuber, Birgit Belter, Ralf Bergmann, Jens Lenk, Robert Wodtke, Torsten Kniess, Jörg Steinbach, Jens Pietzsch, Reik Löser
Accumulating evidence suggests an unequivocal role of lysyl oxidases as key players of tumor progression and metastasis, which renders this enzyme family highly attractive for targeted non-invasive functional imaging of tumors. Considering their function in matrix remodeling, malignant melanoma appears as particularly interesting neoplasia in this respect. For the development of radiotracers that enable PET imaging of the melanoma-associated lysyl oxidase activity, substrates derived from the type I collagen α1 N-telopeptide were labeled with fluorine-18 using N -succinimidyl 4-[18 F]fluorobenzoate ([18 F]SFB) as prosthetic reagent...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29753768/modification-of-collagen-with-three-novel-tannages-sulfonated-calix-4-arenes
#8
REVIEW
Yongxiang Zhou, Jianzhong Ma, Dangge Gao, Lu Jia, Kaitao Guo, Huijun Ren
Chromium (III) salts are the most extensively used tanning agents due to the higher quality and stabilization ability to leather collagen. However, chromium (III) salts tanning agent has a strong impact on the environment owing to the pollution of wastewater and the solid waste containing chrome. In order to crosslink the collagen by a cleaner method, three kinds of sulfonated calix[4]arenes {sulfonated calix[4]arene (SC), sulfonated tetraphenyl calix[4]resorcinarene (STCR), and sulfonated tetramethylene tetraphenyl calix[4]resorcinarene(STTCR)} were prepared and utilized for the collagen crosslinking and leather tanning...
May 10, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29750010/comparative-analysis-of-safety-and-efficacy-of-photorefractive-keratectomy-versus-photorefractive-keratectomy-combined-with-crosslinking
#9
Gitansha Shreyas Sachdev, Shreyas Ramamurthy, Ramamurthy Dandapani
Purpose: To assess the safety, efficacy, and refractive predictability of half-fluence accelerated corneal collagen crosslinking (CXL) applied concurrently with photorefractive keratectomy (PRK), and compare the results to standard PRK. Setting: Refractive Services, The Eye Foundation, Coimbatore, India. Design: Interventional comparative case series. Methods: Patients seeking refractive correction for myopia or myopic astigmatism were included in the study...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29732010/lysyl-oxidase-family-members-in-urological-tumorigenesis-and-fibrosis
#10
REVIEW
Tao Li, Changjing Wu, Liang Gao, Feng Qin, Qiang Wei, Jiuhong Yuan
Lysyl oxidase (LOX) is an extracellular copper-dependent monoamine oxidase that catalyzes crosslinking of soluble collagen and elastin into insoluble, mature fibers. Lysyl oxidase-like proteins (LOXL), LOX isozymes with partial structural homology, exhibit similar catalytic activities. This review summarizes recent findings describing the roles of LOX family members in urological cancers and fibrosis. LOX/LOXL play key roles in extracellular matrix stability and integrity, which is essential for normal female pelvic floor function...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29730855/chitosan-gelatin-scaffolds-support-bone-regeneration
#11
Anthie Georgopoulou, Fotios Papadogiannis, Aristea Batsali, John Marakis, Kalliopi Alpantaki, Aristides G Eliopoulos, Charalampos Pontikoglou, Maria Chatzinikolaidou
Chitosan/Gelatin (CS:Gel) scaffolds were fabricated by chemical crosslinking with glutaraldehyde or genipin by freeze drying. Both crosslinked CS:Gel scaffold types with a mass ratio of 40:60% form a gel-like structure with interconnected pores. Dynamic rheological measurements provided similar values for the storage modulus and the loss modulus of the CS:Gel scaffolds when crosslinked with the same concentration of glutaraldehyde vs. genipin. Compared to genipin, the glutaraldehyde-crosslinked scaffolds supported strong adhesion and infiltration of pre-osteoblasts within the pores as well as survival and proliferation of both MC3T3-E1 pre-osteoblastic cells after 7 days in culture, and human bone marrow mesenchymal stem cells (BM-MSCs) after 14 days in culture...
May 5, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29730278/relationships-between-human-cortical-bone-toughness-and-collagen-cross-links-on-paired-anatomical-locations
#12
Rémy Gauthier, Hélène Follet, Max Langer, Evelyne Gineyts, Frédéric Rongiéras, Françoise Peyrin, David Mitton
Human cortical bone fracture processes depend on the internal porosity network down to the lacunar length scale. Recent results show that at the collagen scale, the maturation of collagen cross-links may have a negative influence on bone mechanical behavior. While the effect of pentosidine on human cortical bone toughness has been studied, the influence of mature and immature enzymatic cross-links has only been studied in relation to strength and work of fracture. Moreover, these relationships have not been studied on different paired anatomical locations...
May 3, 2018: Bone
https://www.readbyqxmd.com/read/29721363/prolonged-survival-of-transplanted-stem-cells-after-ischaemic-injury-via-the-slow-release-of-pro-survival-peptides-from-a-collagen-matrix
#13
Andrew S Lee, Mohammed Inayathullah, Maarten A Lijkwan, Xin Zhao, Wenchao Sun, Sujin Park, Wan Xing Hong, Mansi B Parekh, Andrey V Malkovskiy, Edward Lau, Xulei Qin, Venkata Raveendra Pothineni, Verónica Sanchez-Freire, Wendy Y Zhang, Nigel G Kooreman, Antje D Ebert, Charles K F Chan, Patricia K Nguyen, Jayakumar Rajadas, Joseph C Wu
Stem-cell-based therapies hold considerable promise for regenerative medicine. However, acute donor-cell death within several weeks after cell delivery remains a critical hurdle for clinical translation. Co-transplantation of stem cells with pro-survival factors can improve cell engraftment, but this strategy has been hampered by the typically short half-lives of the factors and by the use of Matrigel and other scaffolds that are not chemically defined. Here, we report a collagen-dendrimer biomaterial crosslinked with pro-survival peptide analogues that adheres to the extracellular matrix and slowly releases the peptides, significantly prolonging stem cell survival in mouse models of ischaemic injury...
February 2018: Nature Biomedical Engineering
https://www.readbyqxmd.com/read/29719605/-in-vivo-safety-and-efficacy-testing-of-a-thermally-triggered-injectable-hydrogel-scaffold-for-bone-regeneration-and-augmentation-in-a-rat-model
#14
Abbey A Thorpe, Christine Freeman, Paula Farthing, Jill Callaghan, Paul V Hatton, Ian M Brook, Chris Sammon, Christine Lyn Le Maitre
Bone loss resulting from degenerative diseases and trauma is a significant clinical burden which is likely to grow exponentially with the aging population. In a number of conditions where pre-formed materials are clinically inappropriate an injectable bone forming hydrogel could be beneficial. The development of an injectable hydrogel to stimulate bone repair and regeneration would have broad clinical impact and economic benefit in a variety of orthopedic clinical applications. We have previously reported the development of a Laponite® crosslinked pNIPAM-co-DMAc (L-pNIPAM-co-DMAc) hydrogel delivery system, loaded with hydroxyapatite nanoparticles (HAPna), which was capable of inducing osteogenic differentiation of mesenchymal stem cells (MSCs) without the need for additional growth factors in vitro ...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29709829/fabrication-and-characterization-of-collagen-based-injectable-and-self-crosslinkable-hydrogels-for-cell-encapsulation
#15
Yongli Gao, Weili Kong, Bao Li, Yilu Ni, Tun Yuan, Likun Guo, Hai Lin, Hongsong Fan, Yujiang Fan, Xingdong Zhang
Injectable and self-crosslinkable hydrogels have drawn much attention for their potential application as cell delivery carriers to deliver cells to the injury site of arbitrary shape. In this study, injectable and self-crosslinkable hydrogels were designed and fabricated based on collagen type I (Col I) and activated chondroitin sulfate (CS-sNHS) by physical and chemical crosslinking without the addition of any catalysts. The physical properties of hydrogels, including mechanical properties, swelling and degradation properties, were investigated...
April 4, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29708307/inkjet-spray-hybrid-printing-for-3d-freeform-fabrication-of-multilayered-hydrogel-structures
#16
Sejeong Yoon, Ju An Park, Hwa-Rim Lee, Woong Hee Yoon, Dong Soo Hwang, Sungjune Jung
Here, a new bioprinting process by combining drop-on-demand inkjet printing with a spray-coating technique, which enables the high-resolution, high-speed, and freeform fabrication of large-scale cell-laden hydrogel structures is reported. Hydrogel structures with various shapes and composed of different materials, including alginate, cellulose nanofiber, and fibrinogen, are fabricated using the inkjet-spray printing. To manufacture cell-friendly hydrogel structures with controllable stiffness, gelatine methacryloyl is saponified to stabilize jet formation and is subsequently mixed with sodium alginate to prepare blend inks...
April 30, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29704312/self-expandable-tubular-collagen-implants
#17
Luuk R M Versteegden, Marja Ter Meer, Roger M L M Lomme, J Adam van der Vliet, Leo J Schultze Kool, Toin H van Kuppevelt, Willeke F Daamen
Collagen has been extensively used as a biomaterial, yet for tubular organ repair synthetic polymers or metals (e.g. stents) are typically used. In this study we report a novel type of tubular implant solely consisting of type I collagen, suitable to self-expand in case of minimal invasive implantation. Potential benefits of this collagen scaffold over conventional materials include improved endothelialization, biodegradation over time and possibilities to add bioactive components to the scaffold, such as anti-coagulants...
April 28, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29679381/comparative-gel-based-proteomic-analysis-of-chemically-crosslinked-complexes-in-dystrophic-skeletal-muscle
#18
Sandra Murphy, Margit Zweyer, Rustam R Mundegar, Dieter Swandulla, Kay Ohlendieck
Duchenne muscular dystrophy is a highly progressive muscle wasting disease with a complex pathophysiology that is based on primary abnormalities in the dystrophin gene. In order to study potential changes in the oligomerisation of high-molecular-mass protein complexes in dystrophic skeletal muscle, chemical crosslinking was combined with mass spectrometric analysis. The biochemical stabilization of protein interactions was carried out with the homo-bifunctional and amine-reactive agent bis[sulfosuccinimidyl]suberate, followed by protein shift analysis in one-dimensional gels...
April 20, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29677555/matrix-architecture-plays-a-pivotal-role-in-3d-osteoblast-migration-the-effect-of-interstitial-fluid-flow
#19
Cristina Del Amo, Vanesa Olivares, Mar Cóndor, Alejandro Blanco, Jorge Santolaria, Jesús Asín, Carlos Borau, José Manuel García-Aznar
Osteoblast migration is a crucial process in bone regeneration, which is strongly regulated by interstitial fluid flow. However, the exact role that such flow exerts on osteoblast migration is still unclear. To deepen the understanding of this phenomenon, we cultured human osteoblasts on 3D microfluidic devices under different fluid flow regimes. Our results show that a slow fluid flow rate by itself is not able to alter the 3D migratory patterns of osteoblasts in collagen-based gels but that at higher fluid flow rates (increased flow velocity) may indirectly influence cell movement by altering the collagen microstructure...
April 10, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29677113/growing-neural-pc-12-cell-on-crosslinked-silica-aerogels-increases-neurite-extension-in-the-presence-of-an-electric-field
#20
Kyle J Lynch, Omar Skalli, Firouzeh Sabri
Externally applied electrical stimulation (ES) has been shown to enhance the nerve regeneration process and to influence the directionality of neurite outgrowth. In addition, the physical and chemical properties of the substrate used for nerve-cell regeneration is critical in fostering regeneration. Previously, we have shown that polyurea-crosslinked silica aerogels (PCSA) exert a positive influence on the extension of neurites by PC-12 cells, a cell-line model widely used to study neurite extension and electrical excitability...
April 20, 2018: Journal of Functional Biomaterials
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