keyword
MENU ▼
Read by QxMD icon Read
search

Lipides

keyword
https://www.readbyqxmd.com/read/29055229/effect-of-long-term-chilled-up-to-5weeks-then-frozen-up-to-12months-storage-at-two-different-sub-zero-holding-temperatures-on-beef-2-lipid-oxidation-and-fatty-acid-profiles
#1
Benjamin W B Holman, Cassius E O Coombs, Stephen Morris, Kristy Bailes, David L Hopkins
Lipid oxidation and fatty acid (FA) profiles were evaluated for beef M. longissimus lumborum (LL) stored under different chilled-then-frozen storage combinations (up to 5 and 52weeks, respectively) and two frozen holding temperatures (-12°C and -18°C). FA profile variation was observed, with increasing frozen storage periods resulting in unsaturated FA levels declining as saturated FA levels increased. Polyunsaturated and health claimable FA levels also tended to decline with increasing chilled storage period, albeit insignificant within the constraints of the experimental design...
October 6, 2017: Meat Science
https://www.readbyqxmd.com/read/29055171/safer-and-healthier-reduced-nitrites-turkey-meat-sausages-using-lyophilized-cystoseira-barbata-seaweed-extract
#2
Sabrine Sellimi, Abdelkarim Benslima, Ghada Ksouda, Veronique Barragan Montero, Mohamed Hajji, Moncef Nasri
Background Nitrite salts are still common additives in the meat industry. The present study provides a first approach on the employment of the lyophilized aqueous extract (WE) of the Tunisian seaweed Cystoseira barbata for the quality enhancement of turkey meat sausage. Methods WE was supplemented as a natural antioxidant agent to investigate its effectiveness in delaying lipid oxidation turkey meat sausages containing reduced amounts of sodium nitrites. Results On storage day 5, all concentrations of WE (0...
October 21, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29055069/evidence-of-evolutionary-optimization-of-fatty-acid-length-and-unsaturation
#3
I Galván
The lipid composition of cell membranes exerts a crucial influence on cell physiology. Indeed, one double bond triggers membrane fluidity, essential for cell functionality, but additional double bonds increase the susceptibilty to peroxidation, which produces reactive compounds that impair the viability of cells. It has therefore been suggested, but never tested in an extensive comparative context, that the composition of membrane fatty acids has been optimized during evolution. A similar prediction has been made for fatty acid chain length, on which susceptibility to peroxidation also depends...
October 20, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29055024/serum-lipid-vitamin-d-levels-and-obesity-in-perimenopausal-and-postmenopausal-women-in-non-manual-employment
#4
Jarosław Pinkas, Iwona Bojar, Mariusz Gujski, Joanna Bartosińska, Alfred Owoc, Dorota Raczkiewicz
BACKGROUND Increasing age, increased body mass index (BMI), and abnormal lipid profiles contribute to an increased risk of vitamin D deficiency. Women who have a perimenopausal and postmenopausal reduction in estrogen levels are a high-risk group for vitamin D deficiency. The aims of this study were to compare the serum vitamin D levels, lipid profile, and BMI between perimenopausal and postmenopausal women in non-manual employment, and to determine whether there were any interdependent factors. MATERIAL AND METHODS Three hundred women in non-manual employment, aged between 44-66 years, were divided into three groups: early perimenopausal; late perimenopausal; and postmenopausal...
October 21, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29055017/new-generation-nanomedicines-constructed-from-self-assembling-small-molecule-prodrugs-alleviate-cancer-drug-toxicity
#5
Hangxiang Wang, Zhongjie Lu, Lijiang Wang, Tingting Guo, Jiaping Wu, Jianqin Wan, Liqian Zhou, Hui Li, Zhen Li, Donghai Jiang, Penghong Song, Haiyang Xie, Lin Zhou, Xiao Xu, Shusen Zheng
The therapeutic index for chemotherapeutic drugs is determined in part by systemic toxicity, so strategies for dose intensification to improve efficacy must also address tolerability. In addressing this issue, we have investigated a novel combinatorial strategy of reconstructing a drug molecule and using sequential drug-induced nanoassembly to fabricate supramolecular nanomedicines (SNM). Using cabazitaxel (CTX) as a target agent, we established that individual synthetic prodrugs tethered with polyunsaturated fatty acids were capable of recapitulating self-assembly behavior independent of exogenous excipients...
October 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/29054999/a-molecular-basis-of-human-t-cell-receptor-autoreactivity-toward-self-phospholipids
#6
Adam Shahine, Ildiko Van Rhijn, Tan-Yun Cheng, Sarah Iwany, Stephanie Gras, D Branch Moody, Jamie Rossjohn
Human T cell autoreactivity toward lipid antigens presented by CD1 proteins can manifest in numerous diseases, including psoriasis, contact hypersensitivities, and allergies. However, the molecular mechanisms for regulating T cell autoreactivity toward lipid antigens remain unclear. We determined the basis for T cell receptor (TCR) autoreactivity toward CD1b bound to self-phospholipids. The spectrum of self-antigens captured by CD1b skews toward abundant membrane phospholipids such as phosphatidylcholine and phosphatidylethanolamine...
October 20, 2017: Science Immunology
https://www.readbyqxmd.com/read/29054822/determining-the-effects-of-pei-adsorption-on-the-permeability-of-dppc-bmp-membranes-under-osmotic-stress
#7
Scott R Clark, Keel Yong Lee, Hoyoung Lee, Jawahar Khetan, Hyun Chang Kim, Yun Hwa Choi, Kwanwoo Shin, You-Yeon Won
Polycations are used for a number of biological applications, including antibiotics and gene therapy. One aspect of the use of polycation gene carriers such as polyethylenemine (PEI) in gene therapy that is not well understood is their ability to escape from the vesicles they are internalized in. Here, in an attempt to gain a better understanding of PEI interaction with endosomal lipids under osmotic stress, we performed investigations using monolayers and vesicles derived from a mixture of neutral and negative lipids (1,2-dipalmitoylphosphatidylcholine (DPPC) and bis(monoacylglycero)phosphate (BMP), respectively)...
October 17, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29054808/high-amylose-starch-consumption-induces-obesity-in-drosophila-melanogaster-and-metformin-partially-prevents-accumulation-of-storage-lipids-and-shortens-lifespan-of-the-insects
#8
Oleksandra B Abrat, Janet M Storey, Kenneth B Storey, Volodymyr I Lushchak
There are very few studies that have directly analyzed the effects of dietary intake of slowly digestible starches on metabolic parameters of animals. The present study examined the effects of slowly digestible starch with high amylose content (referred also as amylose starch) either alone, or in combination with metformin on the development, lifespan, and levels of glucose and storage lipids in the fruit fly Drosophila melanogaster. Consumption of amylose starch in concentrations 0.25-10% did not affect D...
October 17, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/29054722/the-eyelids-and-tear-film-in-contact-lens-discomfort
#9
Jaya Sowjanya Siddireddy, Ajay Kumar Vijay, Jacqueline Tan, Mark Willcox
PURPOSE: To investigate characteristics of the eyelid margins, meibomian glands and the tear film of contact lens wearers, and to determine whether these characteristics were related to symptoms of contact lens discomfort. METHODS: A cross sectional study was performed on thirty existing daily wear soft contact lens wearers (6 male; 24 female) with median age of 23 years (range 18-41). Eyelid signs and tear film characteristics were evaluated during a single visit and subjects completed the contact lens and dry eye questionnaire (CLDEQ-8) to evaluate ocular discomfort...
October 17, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29054699/silymarin-attenuated-paraquat-induced-cytotoxicity-in-macrophage-by-regulating-trx-txnip-complex-inhibiting-nlrp3-inflammasome-activation-and-apoptosis
#10
Zhenning Liu, Mingli Sun, Yu Wang, Lichun Zhang, Hang Zhao, Min Zhao
Oxidative stress and inflammation are involved in paraquat-induced cytotoxicity. Silymarin can exert a potent antioxidative and anti-inflammatory effect in various pathophysiological processes. The aim of this current study is to explore the protective effect and potential mechanism of silymarin in paraquat-induced macrophage injury. Cells were pretreated with different doses of silymarin for 3h before exposure to paraquat. At 24h after exposure to paraquat, the paraquat-induced cytotoxicity to macrophage was measured via the MTT assay and LDH release...
October 17, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29054696/effects-of-articaine-on-3-h-noradrenaline-release-from-cortical-and-spinal-cord-slices-prepared-from-normal-and-streptozotocin-induced-diabetic-rats-and-compared-to-lidocaine
#11
D Végh, A Somogyi, D Bányai, M Lakatos, M Balogh, M Al-Khrasani, S Fürst, E S Vizi, P Hermann
Since a significant proportion of diabetic patients have clinical or subclinical neuropathy, there may be concerns about the use of local anaesthetics. The present study was designed to determine and compare the effects of articaine, a widely used anaesthetic in dental practice, and lidocaine on the resting and axonal stimulation-evoked release of [(3)H]noradrenaline ([(3)H]NA) in prefrontal cortex slices and the release of [(3)H]NA in spinal cord slices prepared from non-diabetic and streptozocin (STZ)-induced diabetic (glucose level=22...
October 17, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29054640/apportioning-source-of-erosion-induced-organic-matter-in-the-hilly-gully-region-of-loess-plateau-in-china-insight-from-lipid-biomarker-and-isotopic-signature-analysis
#12
Chun Liu, Zhongwu Li, Xiaofeng Chang, Xiaodong Nie, Lin Liu, Haibing Xiao, Danyang Wang, Hao Peng, Guangming Zeng
Understanding the dynamics of organic matter (OM) at global and local scales is one of the challenges in the environmental sciences and i.e. terrestrial biogeochemistry. The accurate identification of OM is an essential element to achieve this goal. In our study, a novel application for quantitatively apportioning sources of eroded sedimentary OM from an eco-geomorphologic perspective was shown successfully via a coupled molecular n-alkane biomarkers and stable isotopic signatures ((13)C and (15)N) along with elemental compositions (TOC and TN) using a Bayesian mixing model (SIAR)...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054558/serum-lipid-lipoprotein-and-apolipoprotein-profiles-in-workers-exposed-to-low-arsenic-levels-lipid-profiles-and-occupational-arsenic-exposure
#13
Caterina Ledda, Ivo Iavicoli, Massimo Bracci, Roberto Avola, Paola Senia, Lory Santarelli, Cristoforo Pomara, Venerando Rapisarda
Epidemiologic studies have reported that exposure to arsenic (As) is associated with higher risk of cardiovascular disease (i.e., coronary heart disease and peripheral arterial heart disease) and mortality. This cross-sectional study aimed to compare serum lipid, lipoprotein, and apolipoprotein profiles in workers exposed to As. The subjects of this study included 57 workers exposed to As and 57 controls. Demographic characteristics and occupational information were collected through questionnaires. Exposure to As was assessed in indoor air of a workplace and determined using the creatinine values in the urine...
October 17, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29054541/a-quantitative-assessment-of-the-membrane-integral-sub-proteome-of-a-bacterial-magnetic-organelle
#14
Oliver Raschdorf, Florian Bonn, Natalie Zeytuni, Raz Zarivach, Dörte Becher, Dirk Schüler
Magnetotactic bacteria produce chains of complex membrane-bound organelles that direct the biomineralization of magnetic nanoparticles and serve for magnetic field navigation. These magnetosome compartments have recently emerged as a model for studying the subcellular organization of prokaryotic organelles. Previous studies indicated the presence of specific proteins with various functions in magnetosome biosynthesis. However, the exact composition and stoichiometry of the magnetosome subproteome have remained unknown...
October 17, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29054535/adipose-tissue-inflammation-in-aging
#15
REVIEW
Theresa Mau, Raymond Yung
Adipose tissue has traditionally been viewed as an organ of interest within studies of obesity and diet-associated metabolic disorders. However, as studies reveal the role white adipose tissue plays as an energy storage, a lipid metabolism site, and an adipokine secretor, it has become recognized as an organ of importance for metabolic health in both the young obese and the old obese. Within the realms of aging research, the pursuit of senolytics has taken the field's spotlight, where the clearance of senescent cells has shown to attenuate aspects of age-related disorders...
October 17, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29054476/extracellular-vesicles-as-emerging-targets-in-cancer-recent-development-from-bench-to-bedside
#16
REVIEW
Kerui Wu, Fei Xing, Shih-Ying Wu, Kounosuke Watabe
Extracellular vesicles (EVs) have emerged as important players of cancer initiation and progression through cell-cell communication. They have been recognized as critical mediators of extracellular communications, which promote transformation, growth invasion, and drug-resistance of cancer cells. Interestingly, the secretion and uptake of EVs are regulated in a more controlled manner than previously anticipated. EVs are classified into three groups, (i) exosomes, (ii) microvesicles (MVs), and (iii) apoptotic bodies (ABs), based on their sizes and origins, and novel technologies to isolate and distinguish these EVs are evolving...
October 17, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29054470/circulating-adiponectin-increases-in-obese-women-after-sleeve-gastrectomy-or-gastric-bypass-driving-beneficial-metabolic-changes-but%C3%A2-with-no-relationship-with-carotid-intima-media-thickness
#17
Jesús M Gómez-Martin, José A Balsa, Enrique Aracil, María Insenser, Pablo Priego, Héctor F Escobar-Morreale, José I Botella-Carretero
BACKGROUND & AIMS: Obesity surgery induces beneficial effects in metabolic and cardiovascular parameters. Adiponectin increase might be associated with some of these changes. However, direct comparison between different surgical techniques has not been extensively performed. METHODS: We studied 20 obese women submitted to laparoscopic Roux en Y gastric bypass (RYGB) and 20 to sleeve gastrectomy (SG). Twenty control women matched for age and baseline metabolic profiles were also included...
October 12, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29054469/the-acidity-of-early-pregnancy-diet-and-risk-of-gestational-diabetes-mellitus
#18
Sahar Saraf-Bank, Hotav Tehrani, Fahimeh Haghighatdoost, Seyedeh Parisa Moosavian, Leila Azadbakht
BACKGROUNDS & AIMS: Recently, an increasing interest has been addressed to the acid-base imbalance in the pathogenesis of diabetes while we are not aware of any study among patients affected by gestational diabetes mellitus (GDM). Therefore, the purpose of present study was to reveal the potential relation between dietary acid load (DAL) and glycemic indices, lipid profiles and GDM odds ratio among Iranian pregnant women with GDM. METHODS: This case-control study (hospital-based setting) was performed in singleton fetus pregnant women; healthy (n = 263) and GDM (n = 200), aged 22-44 years, and between weeks 5-28 of pregnancy...
October 3, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29054451/phenolic-alkaloid-oleracein-e-attenuates-oxidative-stress-and-neurotoxicity-in-alcl3-treated-mice
#19
Lingyu Li, Yanni Jiao, Tianyun Jin, Hongxiang Sun, Shaoqiang Li, Cuirong Jin, Shuiyao Hu, Jianbo Ji, Lan Xiang
AIMS: Chelation therapy and antioxidant supplements have been demonstrated to be useful in ameliorating aluminum (Al) induced neurotoxicity. Oleracein E (OE) is a phenolic antioxidant alkaloid which possesses a rare tetrahydroisoquinoline/pyrrolidone tricyclic skeleton and a catechol moiety. The aim of this study was to investigate whether OE can chelate with Al and alleviate AlCl3-induced oxidative stress and neurotoxicity. MAIN METHODS: Kunming mice were administered AlCl3 (40mg/kg/d, i...
October 17, 2017: Life Sciences
https://www.readbyqxmd.com/read/29054372/simultaneously-overcome-tumor-vascular-endothelium-and-extracellular-matrix-barriers-via-a-non-destructive-size-controlled-nanomedicine
#20
Binghua Wang, Yongxia Zhai, Jinjin Shi, Luyang Zhuang, Wei Liu, Huijuan Zhang, Hongling Zhang, Zhenzhong Zhang
Tumor vascular endothelium and extracellular matrix (ECM) as the major barriers of anticancer nanomedicine greatly limited the anticancer efficacy of treatment, but few strategies were available to overcome them simultaneously. Thus, herein a strategy was presented to utilize reversible vasodilatation effect of nitric oxide (NO) and size-controlled characteristic of ultrasound responsive liposome (URL) to construct a non-destructive nanomedicine, which was able to cross both obstacles simultaneously. In this work, URL was built as a carrier via forming a gas layer between lipid bilayer to encapsulate small particles PAMAM@DOX (PD, ~10nm) and NO donation-nitrosoglutathione (GSNO)...
October 17, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
keyword
keyword
21839
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"