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https://www.readbyqxmd.com/read/29475183/the-role-of-dimethyl-sulfoxide-dmso-in-ex-vivo-examination-of-human-skin-burn-injury-treatment
#1
Anna Pielesz, Andrzej Gawłowski, Dorota Biniaś, Rafał Bobiński, Marek Kawecki, Agnieszka Klama-Baryła, Diana Kitala, Wojciech Łabuś, Justyna Glik, Jadwiga Paluch
Dimethyl sulfoxide (DMSO) is one of the most versatile solvents in biological science, therefore it is frequently used as a solvent in biological studies and as a vehicle for drug therapy. DMSO readily penetrates, diffuses through biological membranes and ipso facto increases fluidity of liposomal membranes modelling stratum corneum. Thermal injury is associated with the appearance of lipid peroxidation products in the burned skin. The influence of DMSO on protein structure and stability is concentration and temperature dependant...
February 13, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29475132/differential-effects-of-short-chain-fatty-acids-on-endothelial-nlrp3-inflammasome-activation-and-neointima-formation-antioxidant-action-of-butyrate
#2
Xinxu Yuan, Lei Wang, Owais M Bhat, Hannah Lohner, Pin-Lan Li
Short chain fatty acids (SCFAs), a family of gut microbial metabolites, have been reported to promote preservation of endothelial function and thereby exert anti-atherosclerotic action. However, the precise mechanism mediating this protective action of SCFAs remains unknown. The present study investigated the effects of SCFAs (acetate, propionate and butyrate) on the activation of Nod-like receptor pyrin domain 3 (Nlrp3) inflammasome in endothelial cells (ECs) and associated carotid neointima formation. Using a partial ligated carotid artery (PLCA) mouse model fed with the Western diet (WD), we found that butyrate significantly decreased Nlrp3 inflammasome formation and activation in the carotid arterial wall of wild type mice (Asc+/+ ), which was comparable to the effect of gene deletion of the adaptor protein apoptosis-associated speck-like protein gene (Asc-/- )...
February 13, 2018: Redox Biology
https://www.readbyqxmd.com/read/29475125/reactive-oxygen-species-initiate-a-protective-response-in-plant-roots-to-stress-induced-by-environmental-bisphenol-a
#3
Jiazhi Zhang, Lihong Wang, Qing Zhou, Xiaohua Huang
Bisphenol A (BPA), a contaminant of emerging concern, can affect plant growth and development at high concentrations. Reactive oxygen species (ROS) production is a general primary response in plants to stress. Here, the aim is to investigate whether ROS in plants play protective roles for stress induced by BPA exposure at environmental concentrations. In this study, soybean roots (seedling, flowering and podding stages) were exposed to 1.5 and 3.0 mg L-1 BPA, and ROS response was measured. The relationship between ROS levels and residual BPA content in soybean roots was evaluated...
February 20, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29475106/combining-biotechnology-with-circular-bioeconomy-from-poultry-swine-cattle-brewery-dairy-and-urban-wastewaters-to-biohydrogen
#4
Alice Ferreira, Paula Marques, Belina Ribeiro, Paula Assemany, Henrique Vieira de Mendonça, Ana Barata, Ana Cristina Oliveira, Alberto Reis, Helena M Pinheiro, Luisa Gouveia
The ability of microalgae to grow in nutrient-rich environments and to accumulate nutrients from wastewaters (WW) makes them attractive for the sustainable and low-cost treatment of WW. The valuable biomass produced can be further used for the generation of bioenergy, animal feed, fertilizers, and biopolymers, among others. In this study, Scenedesmus obliquus was able to remove nutrients from different wastewaters (poultry, swine and cattle breeding, brewery and dairy industries, and urban) with removal ranges of 95-100% for nitrogen, 63-99% for phosphorus and 48-70% for chemical oxygen demand...
February 20, 2018: Environmental Research
https://www.readbyqxmd.com/read/29475069/in-vitro-model-to-study-cocaine-and-its-contaminants
#5
Aline Steinmetz, Luiza Steffens, Ana Moira Morás, Flávia Prezzi, Elizandra Braganhol, Jenifer Saffi, Rafael Scorsatto Ortiz, Helena M T Barros, Dinara Jaqueline Moura
Cocaine is one of the most popular illicit drug worldwide. Due its great addictive potential, which leads to euphoria and hyperactivity, it is considered a public health concern. At the central nervous system, the drug acts inhibiting catecholamine re-uptake. It is now known that in addition to the toxicity of the drug itself, the contaminants present in the street drug have raised concern about the harmful effects on health. Toxicological in vivo and in vitro studies have demonstrated the toxic effects of cocaine correlated with the generation of reactive oxygen species (ROS), which in turn lead to oxidative damage to the cells...
February 20, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29475064/ursodeoxycholyl-lysophosphatidylethanolamide-negatively-regulates-tlr-mediated-lipopolysaccharide-response-in-human-thp-1-derived-macrophages
#6
Alzbeta Horvatova, Tanyarath Utaipan, Ann-Christin Otto, Yuling Zhang, Hongying Gan-Schreier, Petr Pavek, Anita Pathil, Wolfgang Stremmel, Walee Chamulitrat
The bile acid-phospholipid conjugate ursodeoxycholyl oleoyl-lysophophatidylethanolamide (UDCA-18:1LPE) is an anti-inflammatory and anti-fibrotic agent as previously shown in cultured hepatocytes and hepatic stellate cells as well as in in vivo models of liver injury. We hypothesize that UDCA-18:1LPE may directly inhibit the activation of immune cells. We found that UDCA-18:1LPE was capable of inhibiting the migration of phorbol ester-differentiated human THP-1 cells. We examined anti-inflammatory activity of UDCA-18:1LPE during activation of THP1-derived macrophages...
February 20, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29475033/morphophysiological-and-transcriptome-analysis-reveals-a-multiline-defense-system-enabling-cyanobacterium-leptolyngbya-strain-jsc-1-to-withstand-iron-induced-oxidative-stress
#7
Sikandar Khan, Jing Lv, Arshad Iqbal, Pengcheng Fu
Iron intoxications induce severe oxidative stress by producing reactive oxygen species (ROS) in cyanobacteria, leading to membrane lipid peroxidation, altered morphology, impaired photosynthesis and other oxidative stress injuries. Given these stresses, mitigation of ROS is a prerequisite for all aerobic organisms. Study of siderophilic cyanobacterium Leptolyngbya strain JSC-1 inhabiting iron-rich hot springs may provide insight into the mechanism of iron homeostasis and alleviation of oxidative stress. In this study, we investigated the morphophysiological and molecular mechanisms enabling this cyanobacterium to cope with iron-induced oxidative stress...
February 19, 2018: Chemosphere
https://www.readbyqxmd.com/read/29475009/effects-of-lipoic-acid-and-n-3-long-chain-polyunsaturated-fatty-acid-on-the-liver-ovariectomized-rat-model-of-menopause
#8
Ártur Krumberg Schüller, Diego Antonio Mena Canata, Fernanda Schäfer Hackenhaar, Vanessa Krüger Engers, Fernanda Maciel Heemann, Jordana Salete Putti, Tiago Boeira Salomon, Mara Silveira Benfato
BACKGROUND: Bilateral ovariectomy is an experimental model used to analyse the effects of menopause and develop strategies to mitigate the deleterious effects of this condition. Supplementation of the diet with antioxidants has been used to reduce potential oxidative stress caused by menopause. The purpose of the study was to analyse the effects of α-lipoic acid (LA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), dietary supplementation on oxidative stress in the livers of ovariectomized rats...
October 19, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29475008/comparison-of-the-effects-of-rosuvastatin-monotherapy-and-atorvastatin-ezetimibe-combined-therapy-on-the-structure-of-erythrocyte-membranes-in-patients-with-coronary-artery-disease
#9
Małgorzata Olszewska-Banaszczyk, Paulina Jackowska, Paulina Gorzelak-Pabiś, Edyta Pytel, Maria Koter-Michalak, Marlena Broncel
BACKGROUND: Abnormalities in the physical properties of the red blood cells (RBCs) membranes may underlie the defects that are strongly linked to cardiovascular diseases (CVD). The aim of the study was to compare the effects of two therapies of equal hipolipemic efficacy on the erythrocyte membrane fluidity, concentration of membrane cholesterol, lipids peroxidation and RBCs distribution witdh in patients with CVD. METHODS: The study included 44 patients with angiographic evidence of CVD, who despite previous 6-month hypolipemic therapy, did not achieve the concentration of LDL-C <70 mg/dl...
November 20, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29475001/regulation-of-tak1-alternative-splicing-by-splice-switching-oligonucleotides
#10
Donghu Zhou, Qianqian Shao, Xu Fan, Peng Wu, Weiran Lin, Handong Wei, Fuchu He, Ying Jiang
Alternative splicing (AS) generates multiple isoforms from a single precursor mRNA, and these isoforms usually exhibit different tissue distributions and functions. Aberrant protein isoforms can lead to abnormalities in protein function and may even result in genetic disorders or cancer. In recent years, splice-switching oligonucleotides (SSOs) have emerged as a promising therapeutic strategy for several neurological diseases, but the efficacy of this strategy in other organs is less reported. In this study, we designed and synthesized SSOs targeting the splicing regulators of exon 12 of the Tak1 gene, inducing variant switching between Tak1-A and Tak1-B...
February 20, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29474971/pre-diagnosis-use-of-statins-associates-with-increased-survival-times-of-patients-with-pancreatic-cancer
#11
Tsuyoshi Hamada, Natalia Khalaf, Chen Yuan, Vicente Morales-Oyarvide, Ana Babic, Jonathan A Nowak, Zhi Rong Qian, Kimmie Ng, Douglas A Rubinson, Peter Kraft, Edward L Giovannucci, Meir J Stampfer, Charles S Fuchs, Shuji Ogino, Brian M Wolpin
BACKGROUND & AIMS: Statin medications, most commonly prescribed to reduce lipid levels and prevent cardiovascular disease, may be associated with longer survival times of patients with cancer. However, the association of statins with outcomes of patients with pancreatic adenocarcinoma is not clear. METHODS: We analyzed the association of statin use before a diagnosis of pancreatic cancer with survival times of 648 participants in the Nurses' Health Study and Health Professionals Follow-up Study who were diagnosed with pancreatic adenocarcinoma from 2000 through 2013...
February 20, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29474941/blocking-wnt5a-signaling-decreases-cd36-expression-and-foam-cell-formation-in-atherosclerosis
#12
Ian Ackers, Candice Szymanski, K Jordan Duckett, Leslie A Consitt, Mitchell J Silver, Ramiro Malgor
BACKGROUND AND AIMS: Wnt5a is a highly studied member of the Wnt family and recently has been implicated in the pathogenesis of atherosclerosis, but its precise role is unknown. Foam cell development is a critical process to atherosclerotic plaque formation. In the present study, we investigated the role of noncanonical Wnt5a signaling in the development of foam cells. METHODS: Human carotid atherosclerotic tissue and THP-1-derived macrophages were used to investigate the contribution of Wnt5a signaling in the formation of foam cells...
February 20, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29474931/alpha-syntrophin-null-mice-are-protected-from-non-alcoholic-steatohepatitis-in-the-methionine-choline-deficient-diet-model-but-not-the-atherogenic-diet-model
#13
Lisa Rein-Fischboeck, Elisabeth M Haberl, Rebekka Pohl, Verena Schmid, Susanne Feder, Sabrina Krautbauer, Gerhard Liebisch, Christa Buechler
Adipose tissue dysfunction contributes to the pathogenesis of non-alcoholic steatohepatitis (NASH). The adapter protein alpha-syntrophin (SNTA) is expressed in adipocytes. Knock-down of SNTA increases preadipocyte proliferation and formation of small lipid droplets, which are both characteristics of healthy adipose tissue. To elucidate a potential protective role of SNTA in NASH, SNTA null mice were fed a methionine-choline-deficient (MCD) diet or an atherogenic diet which are widely used as preclinical NASH models...
February 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29474930/prep1-deficiency-improves-metabolic-response-in-white-adipose-tissue
#14
Antonietta Liotti, Serena Cabaro, Ilaria Cimmino, Serena Ricci, Claudio Procaccini, Orlando Paciello, Gregory A Raciti, Rosa Spinelli, Susanna Iossa, Giuseppe Matarese, Claudia Miele, Pietro Formisano, Francesco Beguinot, Francesco Oriente
Prep1 is a gene encoding for a homeodomain transcription factor which induces hepatic and muscular insulin resistance. In this study, we show that Prep1 hypomorphic heterozygous (Prep1i/+ ) mice, expressing low levels of protein, featured a 23% and a 25% reduction of total body lipid content and epididymal fat, respectively. The percentage of the small adipocytes (25-75 μm) was 30% higher in Prep1i/+ animals than in the WT, with a reciprocal difference in the large adipose cells (100-150 and >150 μm)...
February 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29474925/microrna-221-may-be-involved-in-lipid-metabolism-in-mammary-epithelial-cells
#15
Meiqiang Chu, Yong Zhao, Shuai Yu, Yanan Hao, Pengfei Zhang, Yanni Feng, Hongfu Zhang, Dongxue Ma, Jing Liu, Ming Cheng, Lan Li, Wei Shen, Hongfang Cao, Qiang Li, Lingjiang Min
Milk lipids, important for infant growth and development, are produced and secreted by mammary gland under the regulation of steroid hormones, growth factors, and microRNAs (miRNAs). miR-221 has been identified in milk and adipocytes and it plays important roles in regulating normal mammary epithelial hierarchy and breast cancer stem cells; however, its roles in lipid metabolism in mammary epithelial cells (MECs), the cells of lipid synthesis and secretion, are as yet unknown. Through overexpression or inhibition of miR-221 expression, we found that it regulated lipid metabolism in MECs and was expressed differentially at various stages during murine mammary gland development...
February 20, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29474891/regulation-of-kv7-2-kv7-3-channels-by-cholesterol-relevance-of-an-optimum-plasma-membrane-cholesterol-content
#16
Mayra Delgado-Ramírez, Sergio Sánchez-Armass, Ulises Meza, Aldo A Rodríguez-Menchaca
Kv7.2/Kv7.3 channels are the molecular correlate of the M-current, which stabilizes the membrane potential and controls neuronal excitability. Previous studies have shown the relevance of plasma membrane lipids on both M-currents and Kv7.2/Kv7.3 channels. Here, we report the sensitive modulation of Kv7.2/Kv7.3 channels by membrane cholesterol level. Kv7.2/Kv7.3 channels transiently expressed in HEK-293 cells were significantly inhibited by decreasing the cholesterol level in the plasma membrane by three different pharmacological strategies: methyl-β-cyclodextrin (MβCD), Filipin III, and cholesterol oxidase treatment...
February 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29474890/structural-model-of-the-sars-coronavirus-e-channel-in-lmpg-micelles
#17
Wahyu Surya, Yan Li, Jaume Torres
Coronaviruses (CoV) cause common colds in humans, but are also responsible for the recent Severe Acute, and Middle East, respiratory syndromes (SARS and MERS, respectively). A promising approach for prevention are live attenuated vaccines (LAVs), some of which target the envelope (E) protein, which is a small membrane protein that forms ion channels. Unfortunately, detailed structural information is still limited for SARS-CoV E, and non-existent for other CoV E proteins. Herein, we report a structural model of a SARS-CoV E construct in LMPG micelles with, for the first time, unequivocal intermolecular NOEs...
February 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29474877/the-grp78-bip-inhibitor-ha15-synergizes-with-mitotane-action-against-adrenocortical-carcinoma-cells-through-convergent-activation-of-er-stress-pathways
#18
Carmen Ruggiero, Mabrouka Doghman-Bouguerra, Cyril Ronco, Rachid Benhida, Stéphane Rocchi, Enzo Lalli
Many types of cancer cells present constitutively activated ER stress pathways because of their significant burden of misfolded proteins coded by mutated and rearranged genes. Further increase of ER stress by pharmacological intervention may shift the balance towards cell death and can be exploited therapeutically. Recent studies have shown that an important component in the mechanism of action of mitotane, the only approved drug for the medical treatment of adrenocortical carcinoma (ACC), is represented by activation of ER stress through inhibition of the SOAT1 enzyme and accumulation of toxic lipids...
February 20, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29474811/evaluation-of-behavioral-parameters-hematological-markers-liver-and-kidney-functions-in-rodents-exposed-to-deepwater-horizon-crude-oil-and-corexit
#19
Sindhu Ramesh, Dwipayan Bhattacharya, Mohammed Majrashi, Marlee Morgan, T Prabhakar Clement, Muralikrishnan Dhanasekaran
The 2010 Deepwater Horizon (DWH) oil spill is the largest marine oil spill in US history. In the aftermath of the spill, the response efforts used a chemical dispersant, Corexit, to disperse the oil spill. The health impacts of crude oil and Corexit mixture to humans, mammals, fishes, and birds are mostly unknown. The purpose of this study is to investigate the in vivo effects of DWH oil, Corexit, and oil-Corexit mixture on the general behavior, hematological markers, and liver and kidney functions of rodents...
February 20, 2018: Life Sciences
https://www.readbyqxmd.com/read/29474705/pcb126-inhibits-the-activation-of-ampk-creb-signal-transduction-required-for-energy-sensing-in-liver
#20
Gopi S Gadupudi, Benjamin A Elser, Fabian A Sandgruber, Xueshu Li, Katherine N Gibson-Corley, Larry W Robertson
3,3',4,4',5-pentachlorobiphenyl (PCB126), a dioxin-like PCB, elicits toxicity through a wide array of non-carcinogenic effects, including metabolic syndrome, wasting, and non-alcoholic fatty-liver disease (NAFLD). Previously, we reported decreases in the transcription of several enzymes involved in gluconeogenesis, before the early onset of lipid accumulation. Hence, this study was aimed at understanding the impact of resultant decreases gluconeogenic enzymes on growth, weight and metabolism in the liver, upon extended exposure...
February 20, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
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