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https://www.readbyqxmd.com/read/28939749/cd90-expression-controls-migration-and-predicts-dasatinib-response-in-glioblastoma
#1
Tony Avril, Amandine Etcheverry, Raphaël Pineau, Joanna Obacz, Gwénaële Jegou, Florence Jouan, Pierre-Jean Le Reste, Masumeh Hatami, Rivka R Colen, Brett L Carlson, Paul A Decker, Jann N Sarkaria, Elodie Vauléon, Dan Cristian Chiforeanu, Anne Clavreul, Jean Mosser, Eric Chevet, Véronique Quillien
PURPOSE: CD90 (Thy-1) is a glycophosphatidylinositol-anchored glycoprotein considered as a surrogate marker for a variety of stem cells including glioblastoma (GBM) stem cells (GSCs). However, the molecular and cellular functions of CD90 remain unclear. EXPERIMENTAL DESIGN: The function of CD90 in GBM was addressed using cellular models from immortalized and primary GBM lines, in vivo orthotopic mouse models, GBM specimens' transcriptome associated with MRI features from GBM patients...
September 22, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28938397/regulation-of-orbital-fibrosis-and-adipogenesis-by-pathogenic-th17-cells-in-graves-orbitopathy
#2
Sijie Fang, Yazhuo Huang, Sisi Zhong, Yangyang Li, Yidan Zhang, Yinwei Li, Jing Sun, Xingtong Liu, Yang Wang, Shuo Zhang, Tianle Xu, Xiaodong Sun, Ping Gu, Dan Li, Huifang Zhou, Bin Li, Xianqun Fan
Context: Th17 cells are correlated with many human autoimmune disorders including Graves' disease, and may play key roles in the pathogenesis of Graves' orbitopathy (GO). Objective: To study the phenotype of Th17 cells in patients with GO and healthy subjects, investigate the fibrosis and adipogenesis in orbital fibroblasts (OFs) modulated by IL-17A, and determine the interaction between Th17 cells and OFs. Design/Setting/Participants: Blood samples and orbital tissues from GO patients and healthy controls were collected...
August 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28935974/membrane-particles-generated-from-mesenchymal-stromal-cells-modulate-immune-responses-by-selective-targeting-of-pro-inflammatory-monocytes
#3
Fabiany da C Gonçalves, Franka Luk, Sander S Korevaar, Rachid Bouzid, Ana H Paz, Carmen López-Iglesias, Carla C Baan, Ana Merino, Martin J Hoogduijn
Mesenchymal stromal cells (MSC) are a promising therapy for immunological disorders. However, culture expanded MSC are large and get trapped in the capillary networks of the lungs after intravenous infusion, where they have a short survival time. Hypothetically, living cells are a risk for tumor formation. To reduce risks associated with MSC infusion and improve the distribution in the body, we generated membrane particles (MP) of MSC and MSC stimulated with IFN-γ (MPγ). Tracking analysis and electron microscopy indicated that the average size of MP was 120 nm, and they showed a round shape...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28930164/liver-cancer-molecular-characterization-clonal-evolution-and-cancer-stem-cells
#4
REVIEW
Germana Castelli, Elvira Pelosi, Ugo Testa
Liver cancer is the second most common cause of cancer-related death. The major forms of primary liver cancer are hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). Both these tumors develop against a background of cirrhotic liver, non-alcoholic fatty liver disease, chronic liver damage and fibrosis. HCC is a heterogeneous disease which usually develops within liver cirrhosis related to various etiologies: hepatitis B virus (HBV) infection (frequent in Asia and Africa), hepatitis C virus (HCV), chronic alcohol abuse, or metabolic syndrome (frequent in Western countries)...
September 20, 2017: Cancers
https://www.readbyqxmd.com/read/28929517/neural-differentiation-of-bone-marrow-mesenchymal-stem-cells-with-human-brain-derived-neurotrophic-factor-gene-modified-in-functionalized-self-assembling-peptide-hydrogel-in-vitro
#5
Hongbin Luo, Changsheng Xu, Zhiwei Liu, Lin Yang, Yunda Hong, Guisheng Liu, Huifen Zhong, Xinyi Cai, Xuping Lin, Xiaokun Chen, Changsheng Wang, Nanwen Zhang, Weihong Xu
OBJECTIVE: To investigate the biocompatibility and differentiation of human brain-derived neurotrophic factor (hBDNF) gene-modified bone marrow mesenchymal stem cells (hBDNF-rMSCs) in a functionalized self-assembling peptide hydrogel. METHODS: hBDNF were engineered in rMSCs using adenovirus vector and the enhanced green fluorescence protein (eGFP) was used as a reporter gene. MSC-specific surface markers (CD90,CD29 and CD45)were used for identifying rMSCs. Fluorescence microscope was used to detect the transfection of rMSCs...
September 19, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28926198/serum-free-human-msc-medium-supports-consistency-in-human-but-not-in-equine-adipose-derived-multipotent-mesenchymal-stromal-cell-culture
#6
Susanna Schubert, Walter Brehm, Aline Hillmann, Janina Burk
For clinical applications of multipotent mesenchymal stromal cells (MSCs), serum-free culture is preferable to standardize cell products and prevent contamination with pathogens. In contrast to human MSCs, knowledge on serum-free culture of large animal MSCs is limited, despite its relevance for preclinical studies and development of veterinary cellular therapeutics. This study aimed to evaluate the suitability of a commercially available serum-free human MSC medium for culturing equine adipose-derived MSCs in comparison with human adipose MSCs...
September 19, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28921810/bones-morphogenic-protein-4-and-retinoic-acid-combined-treatment-comparative-analysis-for-in-vitro-differentiation-potential-of-murine-mesenchymal-stem-cells-derived-from-bone-marrow-and-adipose-tissue-into-germ-cells
#7
Maryam H Shirzeily, Neda Khanlarkhani, Fardin Amidi, Farshad H Shirzeily, Fereydoon S Aval, Aligholi Sobhani
Nowadays, infertility is no longer considered as an unsolvable disorder due to progresses in germ cells derived from stem lineage with diverse origins. Technical and ethical challenges push researchers to investigate various tissue sources to approach more efficient gametes. The purpose of the current study is to investigate the efficacy of a combined medium, retinoic acid (RA) together with Bone Morphogenic Protein-4 (BMP4), on differentiation of Bone Marrow Mesenchymal Stem Cells (BMMSCs) and adipose-derived mesenchymal stem cells (ADMSCs) into germ cells...
September 18, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28919259/ontogenic-identification-and-analysis-of-mesenchymal-stromal-cell-populations-during-mouse-limb-and-long-bone-development
#8
Gretel Nusspaumer, Sumit Jaiswal, Andrea Barbero, Robert Reinhardt, Dana Ishay Ronen, Alexander Haumer, Thomas Lufkin, Ivan Martin, Rolf Zeller
Bone-derived mesenchymal stromal cells (MSCs) differentiate into multiple lineages including chondro- and osteogenic fates and function in establishing the hematopoietic compartment of the bone marrow. Here, we analyze the emergence of different MSC types during mouse limb and long bone development. In particular, PDGFRα(pos)SCA-1(pos) (PαS) cells and mouse skeletal stem cells (mSSCs) are detected within the PDGFRα(pos)CD51(pos) (PαCD51) mesenchymal progenitors, which are the most abundant progenitors in early limb buds and developing long bones until birth...
September 1, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28906582/mammalian-msc-from-selected-species-features-and-applications
#9
REVIEW
Christiane Uder, Sandra Brückner, Sandra Winkler, Hans-Michael Tautenhahn, Bruno Christ
Mesenchymal stromal/stem cells (MSC) are promising candidates for cellular therapy of different diseases in humans and in animals. Following the guidelines of the International Society for Cell Therapy, human MSC may be identified by expression of a specific panel of cell surface markers (CD105+, CD73+, CD90+, CD34-, CD14-, or CD11b-, CD79- or CD19-, HLA-DR-). In addition, multiple differentiation potential into at least the osteogenic, adipogenic, and chondrogenic lineage is a main criterion for MSC definition...
September 14, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28900199/sorafenib-suppresses-extrahepatic-metastasis-de-novo-in-hepatocellular-carcinoma-through-inhibition-of-mesenchymal-cancer-stem-cells-characterized-by-the-expression-of-cd90
#10
Mariko Yoshida, Taro Yamashita, Hikari Okada, Naoki Oishi, Kouki Nio, Takehiro Hayashi, Yoshimoto Nomura, Tomoyuki Hayashi, Yoshiro Asahina, Mika Ohwada, Hajime Sunagozaka, Hajime Takatori, Federico Colombo, Laura Porretti, Masao Honda, Shuichi Kaneko
Cancer stem cells (CSCs) are a pivotal target for eradicating hepatocellular carcinoma (HCC). We previously reported that distinctive CSCs regulating tumorigenicity (EpCAM(+) CSCs) and metastasis (CD90(+) CSCs) have different epithelial/mesenchymal gene expression signatures. Here, we examined the influence of sorafenib, a multiple-receptor tyrosine kinase inhibitor used as a first-line treatment for advanced HCC, on EpCAM(+) and CD90(+) CSCs. CD90(+) cells showed higher c-Kit gene/protein expression than EpCAM(+) cells...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28891399/response-of-human-fetal-liver-progenitor-cell-types-to-temperature-and-ph-stresses-in-vitro
#11
Eva Schmelzer, Hubert G Foka, Robert L Thompson, Angelo Luca, Bruno Gridelli, Jörg C Gerlach
Prolonged physiological stresses including abnormal pH and temperature are deleterious. Yet, human hepatic progenitors have been shown to be quite tolerant of temporary temperature stress such as in cold ischemia. We aimed to identify how various stresses affect liver progenitors, and to determine whether distinct effects exist on different progenitor cells of the human liver. Total fetal liver cells were exposed to low (25°C), normal (37°C), or high (40°C) temperatures, or low (6.76), normal (7.35), or high (7...
September 11, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28889382/urothelial-carcinoma-stem-cells-current-concepts-controversies-and-methods
#12
Jiri Hatina, Hamendra Singh Parmar, Michaela Kripnerova, Anastasia Hepburn, Rakesh Heer
Cancer stem cells are defined as a self-renewing and self-protecting subpopulation of cancer cells able to differentiate into morphologically and functionally diverse cancer cells with a limited lifespan. To purify cancer stem cells, two basic approaches can be applied, the marker-based approach employing various more of less-specific cell surface marker molecules and a marker-free approach largely based on various self-protection mechanisms. Within the context of urothelial carcinoma, both methods could find use...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28884332/subchondral-mesenchymal-stem-cells-from-osteoarthritic-knees-display-high-osteogenic-differentiation-capacity-through-microrna-29a-regulation-of-hdac4
#13
Wei-Shiung Lian, Ren-Wen Wu, Mel S Lee, Yu-Shan Chen, Yi-Chih Sun, Shing-Long Wu, Huei-Jing Ke, Jih-Yang Ko, Feng-Sheng Wang
Subchondral bone deterioration and osteophyte formation attributable to excessive mineralization are prominent features of end-stage knee osteoarthritis (OA). The cellular events underlying subchondral integrity diminishment remained elusive. This study was undertaken to characterize subchondral mesenchymal stem cells (SMSCs) isolated from patients with end-stage knee OA who required total knee arthroplasty. The SMSCs expressed surface antigens CD29, CD44, CD73, CD90, CD105, and CD166 and lacked CD31, CD45, and MHCII expression...
September 7, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28884087/curcumin-attenuates-harmful-effects-of-arsenic-on-neural-stem-progenitor-cells
#14
Ali Jahanbazi Jahan-Abad, Parastoo Morteza-Zadeh, Sajad Sahab Negah, Ali Gorji
OBJECTIVE: Arsenic, an environmental pollutant, decreases neuronal migration as well as cellular maturation and inhibits the proliferation of neural progenitor cells. Curcumin has been described as an antioxidant and neuroprotective agent with strong therapeutic potential in some neurological disorders. Human adipose-derived stem cells (hADSCs), a source of multipotent stem cells, can self-renew and differentiate into neural cells. The aim of the present study was to investigate the preventive effect of curcumin against arsenic toxic effects on the viability, telomerase activity, and apoptosis of neural stem/progenitor cells (NSPCs) derived from hADSCs...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28881538/-co-culture-with-endometrial-stromal-cells-promotes-the-differentiation-of-menstrual-blood-derived-mesenchymal-stem-cells-into-endometrial-epithelial-cells
#15
Y S Jiang, H Y Zhu, X Y Jin, C Li, J Li, Y L Zhang, S Y Zhang
Objective: To study the potential of differentiation of menstrual blood-derived mesenchymal stem cells (MenSC) into endometrial epithelial cells (EEC) in vitro. Methods: Endometrial stromal cells (ESC) and MenSC were cultured and identified by certain methods.MenSC were co-cultured with ESC, added 10 ng/ml TGF-β1, 10 ng/ml EGF, 10 ng/ml PDGF-BB and 1×10(-7) mol/L 17-β-estradiol.The expression of cytokeratin, which was marker of EEC, was tested by immunofluorescence in differentiated MenSC. Results: MenSC proliferated quickly in vitro, and showed fusiform shape and clear structure within 10 generations...
September 5, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28878242/increased-pd-l1-expression-and-il-6-secretion-characterize-human-lung-tumor-derived-perivascular-like-cells-that-promote-vascular-leakage-in-a-perfusable-microvasculature-model
#16
Colette A Bichsel, Limei Wang, Laurène Froment, Sabina Berezowska, Stefan Müller, Patrick Dorn, Thomas M Marti, Ren-Wang Peng, Thomas Geiser, Ralph A Schmid, Olivier T Guenat, Sean R R Hall
Pericytes represent important support cells surrounding microvessels found in solid organs. Emerging evidence points to their involvement in tumor progression and metastasis. Although reported to be present in the human lung, their specific presence and functional orientation within the tumor microenvironment in non-small cell lung cancer (NSCLC) has not yet been adequately studied. Using a multiparameter approach, we prospectively identified, sorted and expanded mesenchymal cells from human primary NSCLC samples based on co-expression of CD73 and CD90 while lacking hematopoietic and endothelial lineage markers (CD45, CD31, CD14 and Gly-A) and the epithelial marker EpCAM...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28875528/transplantation-of-artificial-human-lymphatic-vascular-tissues-fabricated-using-a-cell-accumulation-technique-and-their-engraftment-in-mouse-tissue-with-vascular-remodeling
#17
Yoshiya Asano, Hiroshi Shimoda, Michiya Matsusaki, Mitsuru Akashi
Transplantation of engineered tissues with microvascular structure is advancing towards therapeutic application to improve the flow of blood and/or lymphatic fluids. In lymphatic disorders, transplantation of tissue-engineered lymphatic grafts can be an ideal treatment for draining excessive lymphatic fluid. In this study, we examined the transplantation of three-dimensional artificial human lymphatic network tissue (AHLT) fabricated by the cell accumulation technique into the subcutaneous tissue and fascia of mice...
September 6, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28874230/therapeutic-effect-of-autologous-compact-bone-derived-mesenchymal-stem-cell-transplantation-on-prion-disease
#18
Zhifu Shan, Yuji Hirai, Momoko Nakayama, Ryo Hayashi, Takeshi Yamasaki, Rie Hasebe, Chang-Hyun Song, Motohiro Horiuchi
Prion diseases are fatal neurodegenerative disorders of humans and animals and no effective treatments are currently available. Allogenic transplantation of immortalized human mesenchymal stem cells (MSCs) can prolong the survival of mice infected with prions. However, autologous transplantation is an appropriate model for evaluating the effects of MSCs on prion diseases. Therefore, we isolated and purified MSCs from the femur and tibia of mice as compact bone-derived MSCs (CB-MSCs). Flow cytometric analysis showed that CB-MSCs were negative for myeloid stem cell-derived cell markers CD11b and CD45, but positive for molecules such as Sca-1, CD105 and CD90...
September 6, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28861309/isolation-and-in-vitro-cultivation-of-human-urine-derived-cells-an-alternative-stem-cell-source
#19
Seçil Erden Tayhan, Gönül Tezcan Keleş, İsmet Topçu, Erol Mir, Saime İsmet Deliloğlu Gürhan
OBJECTIVE: For in vitro tissue engineering in urology, stem cells are commonly isolated from tissue specimens obtained during open or endoscopic surgery. Within the context of the present study our aim was to isolate cells from human urine by an alternative and safe technique rather than using the indicated method. MATERIAL AND METHODS: After human urine samples had been collected from young and healthy donors via urethral catheterization, cells were precipitated by centrifugation and cultured...
September 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28853501/-the-effect-of-toll-like-receptor-4-in-nicotine-suppressing-the-osteogenic-potential-of-periodontal-ligament-stem-cells
#20
Yan Luan, Yang Deqin
Objective To explore the impact of nicotine on proliferation and osteogenic capability of periodontal ligament stem cells (PDLSCs), and the role of Toll-like receptor 4 (TLR4) in nicotine, suppressing the osteogenic capability of PDLSCs. Methods PDLSCs were cultured in vitro, and the flow cytometer was used to identify the surface antigen markers of PDLSCs. WST-1 was used to detect the proliferation ability of PDLSCs, which were stimulated by different concentrations of nicotine. Alizarin red staining was used to observe the formation of mineralized nodules after PDLSCs stimulation with different concentrations of nicotine...
August 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
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